Gene Symbol: PRKCG
Description: protein kinase C gamma
Alias: PKC-gamma, PKCC, PKCG, SCA14, protein kinase C gamma type
Species: human
Products:     PRKCG

Top Publications

  1. Liao G, Wagner D, Hsu M, Leonard J. Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current. Mol Pharmacol. 2001;59:960-4 pubmed
    ..The direct action of PKC on certain NMDA receptor subtypes may be important in any physiological or pathological process where PKC and NR2B/NR1 receptors interact. ..
  2. Nunnari G, Smith J, Daniel R. HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?. J Exp Clin Cancer Res. 2008;27:3 pubmed publisher
    ..We propose that the Tat-induced DNA repair deficiencies may play a significant role in the development of AIDS-associated cancer. ..
  3. Jakobovits A, Rosenthal A, Capon D. Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C. EMBO J. 1990;9:1165-70 pubmed
    ..Our results indicate that PKC regulates the process of HIV-1 transactivation, suggesting a key role for the mitogenic induction of trans-activation in the transition of HIV from latency to productive growth. ..
  4. Autieri M, Carbone C. 14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells. DNA Cell Biol. 1999;18:555-64 pubmed
    ..Thus, 14-3-3gamma may represent a signal transduction protein that is regulated transcriptionally and post-transcriptionally by growth factors. ..
  5. Trzesniewski J, Altmann S, Jäger L, Kapfhammer J. Reduced Purkinje cell size is compatible with near normal morphology and function of the cerebellar cortex in a mouse model of spinocerebellar ataxia. Exp Neurol. 2019;311:205-212 pubmed publisher
    Spinocerebellar ataxia type 14 (SCA14) is a dominantly inherited neurodegenerative disease caused by diverse mutations in the Protein Kinase C gamma (PKCγ) gene which is one of the crucial signaling molecules of Purkinje cells...
  6. Chung S, Polgar J, Reed G. Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets. J Biol Chem. 2000;275:25286-91 pubmed
    ..These results provide evidence that extracellular activation can be coupled through intracellular PKC signaling so as to modulate SNARE protein interactions involved in platelet exocytosis. ..
  7. Chen D, Raskind W, Bird T. Spinocerebellar ataxia type 14. Handb Clin Neurol. 2012;103:555-9 pubmed publisher
    ..A single autopsy has shown loss of cerebellar Purkinje cells. The disease is caused by mutations in the protein kinase C gamma (PKC?, PRKCG) gene with a hotspot for mutations in exon 4. Genetic testing for SCA14 is clinically available.
  8. Cecchi F, Dadousis C, Bozzi R, Fratini F, Russo C, Bandecchi P, et al. Genome scan for the possibility of identifying candidate resistance genes for goat lentiviral infections in the Italian Garfagnina goat breed. Trop Anim Health Prod. 2019;51:729-733 pubmed publisher
    ..In the region 1 Mb upstream the significant SNP, the NLRP12 (NLR family pyrin domain containing 12), the PRKCG (protein kinase C gamma), and the CACNG7 (calcium voltage-gated channel auxiliary subunit gamma 7) were found.
  9. Burnette B, Yu G, Felsted R. Phosphorylation of HIV-1 gag proteins by protein kinase C. J Biol Chem. 1993;268:8698-703 pubmed
    ..These data are consistent with the identification of a highly conserved consensus PKC phosphorylation site motif in the HIV-1 gag protein at Ser111 and suggests that PKC phosphorylation plays an important role in gag protein function. ..

More Information

Publications162 found, 100 shown here

  1. Kuroda S, Tokunaga C, Kiyohara Y, Higuchi O, Konishi H, Mizuno K, et al. Protein-protein interaction of zinc finger LIM domains with protein kinase C. J Biol Chem. 1996;271:31029-32 pubmed
    ..These results suggest that the LIM domain is one of the targets of PKC and that the LIM-PKC interaction may shed light on undefined roles of LIM domain-containing proteins. ..
  2. Mayadevi M, Praseeda M, Kumar K, Omkumar R. Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII. Biochim Biophys Acta. 2002;1598:40-5 pubmed
    ..However, CaMKII shows decreased affinity towards the closely related NR2A subunit due to an -Ile-Asn- motif present as a natural insertion in the analogous sequence on NR2A. ..
  3. Nguyen T, Takemoto L, Takemoto D. Inhibition of gap junction activity through the release of the C1B domain of protein kinase Cgamma (PKCgamma) from 14-3-3: identification of PKCgamma-binding sites. J Biol Chem. 2004;279:52714-25 pubmed
    ..This demonstrates that synthetic peptides can be used to exogenously regulate gap junctions. ..
  4. Seki T, Shimahara T, Yamamoto K, Abe N, Amano T, Adachi N, et al. Mutant gammaPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells. Neurobiol Dis. 2009;33:260-73 pubmed publisher
    Missense mutations in protein kinase Cgamma (gammaPKC) gene have been found in spinocerebellar ataxia type 14 (SCA14), an autosomal dominant neurodegenerative disease...
  5. Zhang Y, Hu X, Wang H, Shen W, Liao T, Chen P, et al. Single-nucleotide polymorphisms of the PRKCG gene and osteosarcoma susceptibility. Tumour Biol. 2014;35:12671-7 pubmed publisher
    ..was to explore the relationship between single-nucleotide polymorphisms (SNPs) of the protein kinase C gamma (PRKCG) gene and osteosarcoma susceptibility in Chinese Han population...
  6. Herget T, Oehrlein S, Pappin D, Rozengurt E, Parker P. The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C. Eur J Biochem. 1995;233:448-57 pubmed
    ..There was no dramatic difference in the sequential phosphorylation of MARCKS detectable when comparing the four PKC isotypes. The results are discussed in the context of the functional significance of MARCKS phosphorylation. ..
  7. Kumar S, Sieghart W, Morrow A. Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. J Neurochem. 2002;82:110-7 pubmed
    ..These results suggest that PKCgamma may be involved in GABA(A) receptor adaptations following chronic ethanol consumption. ..
  8. Nery F, Passos D, Garcia V, Kobarg J. Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C. J Biol Chem. 2004;279:11444-55 pubmed
    ..These events associate Ki-1/57 with the RACK1/PKC pathway and may be important for the regulation of its cellular functions. ..
  9. Bareggi R, Grill V, Zweyer M, Narducci P, Martelli A. Distribution of the extended family of protein kinase C isoenzymes in fetal organs of mice: an immunohistochemical study. Cell Tissue Res. 1995;280:617-25 pubmed
    ..One set of antisera was employed to investigate the distribution of the isoforms in selected organs from an earlier developmental age (15 days) and from adult animals.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  10. Gupta S, Aggarwal S, Kim C, Gollapudi S. Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report. Int J Immunopharmacol. 1994;16:197-204 pubmed
    ..The most striking change was observed in PKC-zeta isozymes levels. This study for the first time demonstrates that HIV-1 gp120 affects calcium-independent PKC isozymes in U937 cells. ..
  11. Rodríguez Muñoz M, de la Torre Madrid E, Sánchez Blázquez P, Garzón J. NO-released zinc supports the simultaneous binding of Raf-1 and PKC? cysteine-rich domains to HINT1 protein at the mu-opioid receptor. Antioxid Redox Signal. 2011;14:2413-25 pubmed publisher
    ..This study reveals new aspects of ERK1/2 regulation by the MOR without requiring the transactivation of a receptor tyrosine kinase. ..
  12. Xu H, Bae M, Tovar Y Romo L, Patel N, Bandaru V, Pomerantz D, et al. The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains. J Neurosci. 2011;31:17074-90 pubmed publisher
    ..These findings demonstrate that gp120 contributes to synaptic dysfunction in the setting of HIV infection by interfering with NMDA receptor trafficking...
  13. Chirmule N, Goonewardena H, Pasieka R, Kalyanaraman V, Pahwa S. HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells. J Biol Chem. 1995;270:19364-9 pubmed
    ..g. interleukin-3 and granulocyte macrophage colony-stimulating factor, and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion. ..
  14. Fujita Y, Sasaki T, Fukui K, Kotani H, Kimura T, Hata Y, et al. Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin. J Biol Chem. 1996;271:7265-8 pubmed
  15. Fleming I, Elliott C, Buchanan F, Downes C, Exton J. Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation. J Biol Chem. 1999;274:12753-8 pubmed
    ..These data demonstrate that protein kinase Calpha and Ca2+/calmodulin-dependent protein kinase II phosphorylate Tiam1 in vivo, and that the latter kinase plays a key role in regulating the activity of this exchange factor in vitro. ..
  16. Dryja T, McEvoy J, McGee T, Berson E. No mutations in the coding region of the PRKCG gene in three families with retinitis pigmentosa linked to the RP11 locus on chromosome 19q. Am J Hum Genet. 1999;65:926-8 pubmed
  17. Yamashita I, Sasaki H, Yabe I, Fukazawa T, Nogoshi S, Komeichi K, et al. A novel locus for dominant cerebellar ataxia (SCA14) maps to a 10.2-cM interval flanked by D19S206 and D19S605 on chromosome 19q13.4-qter. Ann Neurol. 2000;48:156-63 pubmed
    ..Multipoint analysis and haplotype reconstruction ultimately traced this novel spinocerebellar ataxia locus (SCA14) to a 10.2-cM interval flanked by D19S206 and D19S605 on chromosome 19q13.4-qter (Zmax = 4...
  18. Schecter A, Berman A, Yi L, Mosoian A, McManus C, Berman J, et al. HIV envelope gp120 activates human arterial smooth muscle cells. Proc Natl Acad Sci U S A. 2001;98:10142-7 pubmed
    ..The activation of smooth muscle cells by gp120 may play an important role in the vascular, thrombotic, and inflammatory responses to HIV infection. ..
  19. Sailer A, Scholz S, Gibbs J, Tucci A, Johnson J, Wood N, et al. Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases. Neurology. 2012;79:127-31 pubmed publisher
    ..Here we describe the use of exome sequencing to investigate a large, 5-generational British kindred with an autosomal dominant, progressive cerebellar ataxia in which conventional genetic testing had not revealed a causal etiology...
  20. Xie H, Xu F, Li Y, Zeng Z, Zhang R, Xu H, et al. Increases in PKC gamma expression in trigeminal spinal nucleus is associated with orofacial thermal hyperalgesia in streptozotocin-induced diabetic mice. J Chem Neuroanat. 2015;63:13-9 pubmed publisher
    ..In summary, our results demonstrate that PKCγ might be involved in orofacial thermal hyperalgesia of diabetes, and early insulin treatment might be effective way to treat orofacial PDN. ..
  21. Kang C, Liang C, Ahmad K, Gu Y, Siow S, Colebatch J, et al. High Degree of Genetic Heterogeneity for Hereditary Cerebellar Ataxias in Australia. Cerebellum. 2019;18:137-146 pubmed publisher
    ..8% (23/80) in 14 known HCA loci. The genetic findings included novel variants in ANO10, CACNA1A, PRKCG and SPG7...
  22. Wong M, Hoekstra S, Vowles J, Watson L, Fuller G, Nemeth A, et al. Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation. Acta Neuropathol Commun. 2018;6:99 pubmed publisher
    Spinocerebellar ataxia type 14 (SCA14) is a subtype of the autosomal dominant cerebellar ataxias that is characterized by slowly progressive cerebellar dysfunction and neurodegeneration...
  23. Boesch D, Garvin J. Age-dependent activation of PKC isoforms by angiotensin II in the proximal nephron. Am J Physiol Regul Integr Comp Physiol. 2001;281:R861-7 pubmed
    ..05). Maximum specific binding and affinity of ANG II receptors were not significantly different between young and adult rats. We concluded that the primary PKC isoform activated by ANG II changes during maturation...
  24. Ali A, Hoeflich K, Woodgett J. Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev. 2001;101:2527-40 pubmed
  25. Nakazono A, Adachi N, Takahashi H, Seki T, Hamada D, Ueyama T, et al. Pharmacological induction of heat shock proteins ameliorates toxicity of mutant PKCγ in spinocerebellar ataxia type 14. J Biol Chem. 2018;293:14758-14774 pubmed publisher
    ..We previously reported that spinocerebellar ataxia type 14 (SCA14), a dominant-inherited neurodegenerative disease that affects cerebellar Purkinje cells, is characterized by the ..
  26. McSwine Kennick R, McKeegan E, Johnson M, Morin M. Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones. J Biol Chem. 1991;266:15135-43 pubmed
  27. Andreeva A, Krause E, Müller E, Blasig I, Utepbergenov D. Protein kinase C regulates the phosphorylation and cellular localization of occludin. J Biol Chem. 2001;276:38480-6 pubmed
    ..These findings indicate that protein kinase C is involved in the regulation of occludin function at tight junctions. ..
  28. Saito N, Shirai Y. Protein kinase C gamma (PKC gamma): function of neuron specific isotype. J Biochem. 2002;132:683-7 pubmed
    The gamma isotype of protein kinase C (PKC gamma) is a member of the classical PKC (cPKC) subfamily which is activated by Ca(2+) and diacylglycerol in the presence of phosphatidylserine...
  29. Darlington T, McCarthy R, Cox R, Miyamoto Ditmon J, Gallego X, Ehringer M. Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling. Genes Brain Behav. 2016;15:474-90 pubmed publisher
    ..interaction between ethanol consumption and wheel running include multiple potassium channel genes, Oprm1, Prkcg, Stxbp1, Crhr1, Gabra3, Slc6a13, Stx1b, Pomc, Rassf5 and Camta2...
  30. McGee T, Devoto M, Ott J, Berson E, Dryja T. Evidence that the penetrance of mutations at the RP11 locus causing dominant retinitis pigmentosa is influenced by a gene linked to the homologous RP11 allele. Am J Hum Genet. 1997;61:1059-66 pubmed
    ..The results support the hypothesis that wild-type alleles at the RP11 locus or at a closely linked locus inherited from the noncarrier parents are a major factor influencing the penetrance of pathogenic alleles at this locus. ..
  31. Brusco A, Gellera C, Cagnoli C, Saluto A, Castucci A, Michielotto C, et al. Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families. Arch Neurol. 2004;61:727-33 pubmed 12 cases (SCA1-3, SCA6-8, SCA10, SCA12, FGF14, and DRPLA), and in all but the recently identified SCA14, SCA17, PRKCG and FGF14 genes, the defect consists of the expansion of a short nucleotide repeat...
  32. Klebe S, Durr A, Rentschler A, Hahn Barma V, Abele M, Bouslam N, et al. New mutations in protein kinase Cgamma associated with spinocerebellar ataxia type 14. Ann Neurol. 2005;58:720-9 pubmed
    ..Point mutations in the gene encoding protein kinase Cgamma (PRKCG) are responsible for spinocerebellar ataxia 14 (SCA14)...
  33. Golan S, Entin Meer M, Semo Y, Maysel Auslender S, Mezad Koursh D, Keren G, et al. Gene profiling of human VEGF signaling pathways in human endothelial and retinal pigment epithelial cells after anti VEGF treatment. BMC Res Notes. 2014;7:617 pubmed publisher
    ..more genes in the endothelial cells were up-regulated (KDR, NFATc2) and down-regulated (Pla2g12a, Rac2, HgdC, PRKCG) compared to non-treated controls...
  34. Xue J, Chen Y, Wu Y, Wang Z, Zhou A, Zhang S, et al. Tumour suppressor TRIM33 targets nuclear β-catenin degradation. Nat Commun. 2015;6:6156 pubmed publisher
    ..This work suggests a new therapeutic strategy against human cancers caused by aberrant activation of β-catenin. ..
  35. Shirai Y, Kashiwagi K, Yagi K, Sakai N, Saito N. Distinct effects of fatty acids on translocation of gamma- and epsilon-subspecies of protein kinase C. J Cell Biol. 1998;143:511-21 pubmed
  36. Chen D, Brkanac Z, Verlinde C, Tan X, Bylenok L, Nochlin D, et al. Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia. Am J Hum Genet. 2003;72:839-49 pubmed
    ..4-qter. A particularly compelling candidate gene, PRKCG, encodes protein kinase C gamma (PKC gamma), a member of a family of serine/threonine kinases...
  37. Kim C, Braud S, Isaac J, Roche K. Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillations. J Biol Chem. 2005;280:25409-15 pubmed
    ..The Thr-840 residue is important only in that it is permissive for the PKC-dependent phosphorylation of Ser-839. ..
  38. Lu W, Ziff E. PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking. Neuron. 2005;47:407-21 pubmed
    ..We suggest that the PICK1 interaction with ABP/GRIP is a critical step in controlling GluR2 trafficking. ..
  39. Stevanin G, Hahn V, Lohmann E, Bouslam N, Gouttard M, Soumphonphakdy C, et al. Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14. Arch Neurol. 2004;61:1242-8 pubmed
    ..Spinocerebellar ataxia type 14 (SCA14) is a relatively pure form of autosomal dominant cerebellar ataxia mapped to chromosome 19q and caused by missense ..
  40. Verbeek D, Goedhart J, Bruinsma L, Sinke R, Reits E. PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling. J Cell Sci. 2008;121:2339-49 pubmed publisher
    Spinocerebellar ataxia type 14 (SCA14) is a neurodegenerative disorder caused by mutations in the neuronal-specific protein kinase C gamma (PKCgamma) gene...
  41. Janda E, Palmieri C, Pisano A, Pontoriero M, Iaccino E, Falcone C, et al. Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtk?. Blood. 2011;117:6520-31 pubmed publisher
    ..These findings identify a novel pathway of Btk regulation via protein kinase C phosphorylation of IBtk?. ..
  42. Maharaj N, Wies E, Stoll A, Gack M. Conventional protein kinase C-? (PKC-?) and PKC-? negatively regulate RIG-I antiviral signal transduction. J Virol. 2012;86:1358-71 pubmed publisher
    ..Thus, these findings demonstrate that PKC-?/?-induced RIG-I phosphorylation is a critical regulatory mechanism for controlling RIG-I antiviral signal transduction under normal conditions. ..
  43. Chowdhury I, Koyanagi Y, Kobayashi S, Hamamoto Y, Yoshiyama H, Yoshida T, et al. The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway. Virology. 1990;176:126-32 pubmed
  44. Reed G, Houng A, Fitzgerald M. Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion. Blood. 1999;93:2617-26 pubmed
  45. Nolte D, Klebe S, Baron R, Deuschl G, Muller U. Codon 101 of PRKCG, a preferential mutation site in SCA14. Mov Disord. 2007;22:1831-2 pubmed
  46. Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, et al. Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein. Hum Mol Genet. 2015;24:525-39 pubmed publisher
    ..C (PKC) γ, a serine/threonine kinase mutated in the neurodegenerative disease spinocerebellar ataxia type 14 (SCA14), as a novel amyloidogenic protein with no previously characterized amyloid-prone domains...
  47. Lu H, Zhu L, Lian L, Chen M, Shi D, Wang K. Genetic variations in the PRKCG gene and osteosarcoma risk in a Chinese population: a case-control study. Tumour Biol. 2015;36:5241-7 pubmed publisher
    ..Protein kinase C gamma (PRKCG) gene, which encodes γPKC, plays important roles in tumor promotion, cell proliferation, differentiation, and ..
  48. Saunders A, Seldin M. The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q. Genomics. 1990;6:324-32 pubmed
    ..Their order from the centromere was Prkcg, [Apoe, Atpa-2, Ckmm, D19S19h, Ercc-2], Cyp2b, Mag, Lhb...
  49. van de Warrenburg B, Verbeek D, Piersma S, Hennekam F, Pearson P, Knoers N, et al. Identification of a novel SCA14 mutation in a Dutch autosomal dominant cerebellar ataxia family. Neurology. 2003;61:1760-5 pubmed
    To report a Dutch family with autosomal dominant cerebellar ataxia (ADCA) based on a novel mutation in the PRKCG gene. The authors studied 13 affected members of the six-generation family...
  50. Asai H, Hirano M, Shimada K, Kiriyama T, Furiya Y, Ikeda M, et al. Protein kinase C gamma, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin. Hum Mol Genet. 2009;18:3533-43 pubmed publisher
    ..14 (SCA14) is an autosomal dominant disease caused by mutations in the gene encoding protein kinase C gamma (PKC gamma)...
  51. Schlaepfer I, Clegg H, Corley R, Crowley T, Hewitt J, Hopfer C, et al. The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibition. Addict Biol. 2007;12:200-9 pubmed
    ..the association between a highly heritable behavioral disinhibition phenotype and the protein kinase C gamma (PRKCG) gene in an ethnically diverse youth sample from Colorado, USA...
  52. Kowara R, Gryckiewicz E, Matecki A, Pawelczyk T. The ultraviolet studies on protein-lipid interaction of a protein kinase C-gamma phorbol-binding domain. Acta Biochim Pol. 1999;46:405-17 pubmed
    ..The site of PIP and PIP2 interaction with PKC-gamma is distinct from that of phorbol ester binding site. ..
  53. Bennasser Y, Bahraoui E. HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta. FASEB J. 2002;16:546-54 pubmed
    ..Altogether, these results suggest that the induction of IL-10 by Tat is strictly dependent on the PKC-delta and -betaII isoforms. ..
  54. Koht J, Stevanin G, Durr A, Mundwiller E, Brice A, Tallaksen C. SCA14 in Norway, two families with autosomal dominant cerebellar ataxia and a novel mutation in the PRKCG gene. Acta Neurol Scand. 2012;125:116-22 pubmed publisher
    ..We wanted to find the occurence of SCA14 in the dominant ataxia population and describe the phenotype.
  55. Schmitz Hubsch T, Brandt A, Pfueller C, Zange L, Seidel A, Kuhn A, et al. Accuracy and repeatability of two methods of gait analysis - GaitRite™ und Mobility Lab™ - in subjects with cerebellar ataxia. Gait Posture. 2016;48:194-201 pubmed publisher
    ..mild to moderate cerebellar ataxia due to a subtype of autosomal-dominantly inherited neurodegenerative disorder (SCA14), the other were healthy subjects matched for age and height (CTR)...
  56. Bai M, Trivedi S, Lane C, Yang Y, Quinn S, Brown E. Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release. J Biol Chem. 1998;273:21267-75 pubmed
    ..Our results suggest that phosphorylation of the CaR is the molecular basis for the previously described effect of PKC activation on Ca2+o-evoked changes in Ca2+i dynamics in parathyroid cells. ..
  57. Caohuy H, Pollard H. Activation of annexin 7 by protein kinase C in vitro and in vivo. J Biol Chem. 2001;276:12813-21 pubmed
    ..These results thus lead us to hypothesize that annexin 7 may be a positive mediator for protein kinase C action in the exocytotic membrane fusion reaction in chromaffin cells. ..
  58. Qian Y, Baisden J, Cherezova L, Summy J, Guappone Koay A, Shi X, et al. PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments. Mol Biol Cell. 2002;13:2311-22 pubmed
  59. Wang X, Zhao J, Tang S, Lee S, Glazer R, Hewlett I. c-FLIPL regulates PKC via AP-2 to inhibit Bax-mediated apoptosis induced by HIV-1 gp120 in Jurkat cells. Mol Cell Biochem. 2009;330:23-9 pubmed publisher
    ..Collectively, these findings further corroborate the concept that gp120 plays an important role, via involvement of molecules such as c-FLIPL, in apoptotic cell death due to HIV-1 infection. ..
  60. Wang H, Jin Y, Dai J. Biological processes and pathway changes in isoflurane-induced anesthesia revealed by bioinformatics analysis of gene expression profiles. J Anesth. 2015;29:912-9 pubmed publisher
    ..g., Slc17a7, Camk4, Syn1, Gria1, Prkcg and Lphn1), as well as KEGG pathways including 'focal adhesion', 'Fc γ R-mediated phagocytosis' (e.g...
  61. Lv Z, Rickman K, Yuan L, Williams K, Selvam S, Woosley A, et al. S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Mol Cell. 2017;65:699-714.e6 pubmed publisher
  62. Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, et al. Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. Genomics. 1993;15:133-45 pubmed
    ..FISH mapping of these cosmids sublocalizes a total of 70 genes and DNA markers on chromosome 19, revises the previously published map assignments of 2 genes, and narrows the location of over 20 markers. ..
  63. Borgatti P, Zauli G, Cantley L, Capitani S. Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. Biochem Biophys Res Commun. 1998;242:332-7 pubmed
    ..Taken together, these findings demonstrate that extracellular Tat shows a cytokine-like activity in PC12 cells, being able to trigger an intracellular signalling cascade which involves PKC-alpha, -epsilon, and -zeta. ..
  64. Krasel C, Dammeier S, Winstel R, Brockmann J, Mischak H, Lohse M. Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin. J Biol Chem. 2001;276:1911-5 pubmed
    ..This inhibition was almost completely abolished in vitro when GRK2 was phosphorylated by PKC. These data suggest that calmodulin may be an inhibitor of GRK2 whose effects can be abolished with PKC-mediated phosphorylation of GRK2. ..
  65. Barclay J, Craig T, Fisher R, Ciufo L, Evans G, Morgan A, et al. Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis. J Biol Chem. 2003;278:10538-45 pubmed
    ..Phosphorylation of Munc18 by PKC may provide a mechanism for the control of exocytosis and thereby synaptic plasticity. ..
  66. Favit A, Grimaldi M, Nelson T, Alkon D. Alzheimer's-specific effects of soluble beta-amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts. Proc Natl Acad Sci U S A. 1998;95:5562-7 pubmed
    ..These results suggest that betaAP(1-40) differentially affects PKC regulation in AC and AD cells via proteolytic degradation and that PKC activation exerts a protective role via de novo protein synthesis in normal but not AD cells. ..
  67. Fang X, Yu S, Lu Y, Bast R, Woodgett J, Mills G. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A. 2000;97:11960-5 pubmed
  68. Vila J, Calvo J, Places L, Padilla O, Arman M, Gimferrer I, et al. Role of two conserved cytoplasmic threonine residues (T410 and T412) in CD5 signaling. J Immunol. 2001;166:396-402 pubmed
    ..These results strongly argue in favor of a role for T410 and T412 in the signaling mediated by CD5. ..
  69. Fagerholm S, Morrice N, Gahmberg C, Cohen P. Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes. J Biol Chem. 2002;277:1728-38 pubmed
    ..Thus, PKC-mediated phosphorylation of CD18 after cell stimulation could lead to the recruitment of 14-3-3 proteins to the activated integrin, which may play a role in regulating its adhesive state or ability to signal. ..
  70. Rodriguez I, Holloschi A, Kaszkin M, Cheng H, Kabsch K, Hafner M, et al. Activation of phospholipase C-gamma1 in human keratinocytes by hyperosmolar shock without enzyme phosphorylation. Arch Dermatol Res. 2004;295:490-7 pubmed
    ..This activation is independent of protein tyrosine phosphorylation and corresponded to a relocation of the enzyme to perinuclear membranes as shown by immunofluorescence. ..
  71. Jarius S, Wildemann B. 'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC. J Neuroinflammation. 2015;12:167 pubmed publisher
  72. Ruegg C, Strand M. A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx. Cell Immunol. 1991;137:1-13 pubmed
  73. Johnson K, Jones P, Spurr N, Nimmo E, Davies J, Creed H, et al. Linkage relationships of the protein kinase C gamma gene which exclude it as a candidate for myotonic dystrophy. Cytogenet Cell Genet. 1988;48:13-5 pubmed
    Using a cDNA probe for the gamma gene of protein kinase C (PKCG), an informative RFLP with a PIC value of 0.62 has been identified with the enzyme MspI. The polymorphic bands have been assigned to chromosome 19...
  74. Zidovetzki R, Wang J, Chen P, Jeyaseelan R, Hofman F. Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways. AIDS Res Hum Retroviruses. 1998;14:825-33 pubmed
    ..Both the Tat-induced increase in intracellular cAMP and IL-6 mRNA levels in CNS-ECs may play a role in altering the blood-brain barrier and thereby inducing pathology often observed in AIDS dementia. ..
  75. Adachi N, Kobayashi T, Takahashi H, Kawasaki T, Shirai Y, Ueyama T, et al. Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis. J Biol Chem. 2008;283:19854-63 pubmed publisher
    Spinocerebellar ataxia type 14 (SCA14) is an autosomal dominant neurodegenerative disease caused by mutations in protein kinase Cgamma (PKCgamma)...
  76. Cho J, Katz D, Skubitz K, Chain B. Conventional protein kinase C plays a critical role in negative regulation of CD98-induced homotypic aggregation. Tissue Antigens. 2010;75:19-29 pubmed publisher
    ..These data provide evidence that PMA-responsive cPKC isoforms (alpha, beta and gamma) play a key role in negative regulation of CD98 signalling and homotypic aggregation. ..
  77. Lessor T, Hamburger A. Regulation of the ErbB3 binding protein Ebp1 by protein kinase C. Mol Cell Endocrinol. 2001;175:185-91 pubmed
    ..These findings suggest that PKC plays a role in regulating phosphorylation and function of Ebp1 in vivo. ..
  78. Lorenz K, Lohse M, Quitterer U. Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature. 2003;426:574-9 pubmed
    ..A physiological role for this mechanism is shown in cardiomyocytes in which the downregulation of RKIP restrains beta-adrenergic signalling and contractile activity. ..
  79. Smith C, Lau K, Rahmani Z, Dho S, Brothers G, She Y, et al. aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb. EMBO J. 2007;26:468-80 pubmed
    ..These results suggest a model in which phosphorylation of Numb by aPKC regulates its polarized distribution in epithelial cells as well as during asymmetric cell divisions. ..
  80. Ko M, Yang M, Youn S, Lan C, Tseng T. Intact subepidermal nerve fibers mediate mechanical hypersensitivity via the activation of protein kinase C gamma in spared nerve injury. Mol Pain. 2016;12: pubmed publisher
    ..The downstream cascades of PDK1 include: (1) protein kinase C gamma (PKCg) controls the trafficking and phosphorylation of ionotropic glutamate receptor; (2) protein kinase B (Akt)/the ..
  81. Parada N, Cruikshank W, Danis H, Ryan T, Center D. IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C. Cell Immunol. 1996;168:100-6 pubmed
    ..Taken together, these data suggest a role for PKC in CD4-mediated migratory responses. ..
  82. Brkanac Z, Bylenok L, Fernandez M, Matsushita M, Lipe H, Wolff J, et al. A new dominant spinocerebellar ataxia linked to chromosome 19q13.4-qter. Arch Neurol. 2002;59:1291-5 pubmed
    ..4-qter in one family. The critical region overlaps with the locus for SCA14, a disease described in a single Japanese family and characterized by axial myoclonus...
  83. Hernandez Pigeon H, Quillet Mary A, Louat T, Schambourg A, Humbert O, Selves J, et al. hMutS alpha is protected from ubiquitin-proteasome-dependent degradation by atypical protein kinase C zeta phosphorylation. J Mol Biol. 2005;348:63-74 pubmed
    ..Altogether, our results indicate that PKC zeta modulates hMutS alpha stability and protein levels, and suggest a role for PKC zeta in genome stability by regulating MMR activity. ..
  84. Garczarczyk D, Szeker K, Galfi P, Csordas A, Hofmann J. Protein kinase Cgamma in colon cancer cells: expression, Thr514 phosphorylation and sensitivity to butyrate-mediated upregulation as related to the degree of differentiation. Chem Biol Interact. 2010;185:25-32 pubmed publisher
  85. Guo W, Chu Y, Imai S, Yang J, Zou S, Mohammad Z, et al. Further observations on the behavioral and neural effects of bone marrow stromal cells in rodent pain models. Mol Pain. 2016;12: pubmed publisher
    ..observed that GluN2A (N-methyl-D-aspartate receptor subunit 2A) tyrosine phosphorylation and protein kinase Cgamma (PKCg) immunoreactivity in rostral ventromedial medulla was suppressed at 8 weeks after BMSC in tendon-injured rats...
  86. Wells N, Fry A, Guano F, Norbury C, Hickson I. Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C. J Biol Chem. 1995;270:28357-63 pubmed
    ..Our results implicate protein kinase C in the cell cycle phase-dependent modulation of topoisomerase II alpha enzymatic activity in human cells. ..
  87. Ward N, Gravitt K, O Brian C. Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein. Cancer Lett. 1995;88:37-40 pubmed
  88. Huang M, Bond V. Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium. J Acquir Immune Defic Syndr. 2000;25:375-89 pubmed
  89. Visser J, Bloem B, van de Warrenburg B. PRKCG mutation (SCA-14) causing a Ramsay Hunt phenotype. Mov Disord. 2007;22:1024-6 pubmed
    ..His father was similarly affected. Genetic studies revealed a mutation in the protein kinase C gamma (PRKCG) gene, known to cause spinocerebellar ataxia type 14 (SCA-14)...
  90. Mlost J, Kostrzewa M, Malek N, Starowicz K. Molecular Understanding of the Activation of CB1 and Blockade of TRPV1 Receptors: Implications for Novel Treatment Strategies in Osteoarthritis. Int J Mol Sci. 2018;19: pubmed publisher
    ..i>Faah, Ptgs2, and Alox12), and TRPV1 sensitizing kinases (Mapk3, Mapk14, Prkcg, and Prkaca)...
  91. Tozser J, Bagossi P, Boross P, Louis J, Majerova E, Oroszlan S, et al. Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates. Eur J Biochem. 1999;265:423-9 pubmed
  92. Jezierska J, Goedhart J, Kampinga H, Reits E, Verbeek D. SCA14 mutation V138E leads to partly unfolded PKC? associated with an exposed C-terminus, altered kinetics, phosphorylation and enhanced insolubilization. J Neurochem. 2014;128:741-51 pubmed publisher
    ..state, conformation or localization can disrupt kinase signalling, such as in spinocerebellar ataxia type 14 (SCA14) that is caused by missense mutations in PRKCG encoding for PKC?...