PRKCG

Summary

Gene Symbol: PRKCG
Description: protein kinase C gamma
Alias: PKC-gamma, PKCC, PKCG, SCA14, protein kinase C gamma type
Species: human

Top Publications

  1. ncbi Nuclear localization signal and phosphorylation of Serine350 specify intracellular localization of DRAK2
    Hiroshi Kuwahara
    Department of Biological Sciences, Graduate School of Science, Osaka University, Machikaneyama cho, Toyonaka City, Osaka, Japan
    J Biochem 143:349-58. 2008
  2. ncbi HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes
    I W Park
    Division of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Blood 97:352-8. 2001
  3. ncbi Glycogen synthase kinase-3: properties, functions, and regulation
    A Ali
    Division of Experimental Therapeutics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Chem Rev 101:2527-40. 2001
  4. ncbi Phosphorylation of HIV-1 gag proteins by protein kinase C
    B Burnette
    Laboratory of Biological Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:8698-703. 1993
  5. ncbi HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system
    H Idriss
    Sealy Center for Molecular Science, The University of Texas Medical Branch Galveston, TX 77555 0851, USA
    Int J Biochem Cell Biol 31:1443-52. 1999
  6. ncbi A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Cell Immunol 137:1-13. 1991
  7. pmc Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
    K Conant
    Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    J Virol 70:1384-9. 1996
  8. pmc The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix
    S Swingler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 71:4372-7. 1997
  9. ncbi 14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells
    M V Autieri
    Department of Cardiology and Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    DNA Cell Biol 18:555-64. 1999
  10. ncbi Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation
    Susana Santos Correia
    Center for Neuroscience and Cell Biology and Department of Biochemistry, University of Coimbra, 3004 517 Coimbra, Portugal
    J Biol Chem 278:6307-13. 2003

Research Grants

  1. Role of Protein Kinase C regulatory domains in modulating alcohol actions
    Joydip Das; Fiscal Year: 2010
  2. Frederick Southwick; Fiscal Year: 2014
  3. Andre Limnander; Fiscal Year: 2014
  4. Lyso-PCs activate PMNs and endothelium via PKC
    CHRISTOPHER SILLIMAN; Fiscal Year: 2006
  5. Function and Modulation of Somatic and Dendritic Kv3.3 Channels in Purkinje Cells
    Edward Zagha; Fiscal Year: 2007
  6. PKC Cys switches -- novel cancer prevention targets
    CATHERINE O BRIAN; Fiscal Year: 2006
  7. 5-HT2 and 5-HT1A Receptors in PKC-gamma Null Mutant Mice
    Barbara Bowers; Fiscal Year: 2005
  8. EXPRESSION OF PROTEIN KINASE C IN LENS EPITHELIAL CELLS
    Karen Gonzalez; Fiscal Year: 1999
  9. Structure Function Studies Of Membrane Binding Proteins
    Wonhwa Cho; Fiscal Year: 2004
  10. RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEM
    NEAL BARMACK; Fiscal Year: 2003

Detail Information

Publications227 found, 100 shown here

  1. ncbi Nuclear localization signal and phosphorylation of Serine350 specify intracellular localization of DRAK2
    Hiroshi Kuwahara
    Department of Biological Sciences, Graduate School of Science, Osaka University, Machikaneyama cho, Toyonaka City, Osaka, Japan
    J Biochem 143:349-58. 2008
    ..These results suggest that phosphorylation of Ser350 plays an essential role in regulating translocation of DRAK2 to the nucleus from the cytoplasm, possibly by affecting the activity of the NLS...
  2. ncbi HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes
    I W Park
    Division of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Blood 97:352-8. 2001
    ..These data indicate that the HIV-1 Tat protein may act as a protocytokine by causing the release of MCP-1 from the endothelial monolayer, and thereby facilitating monocyte transmigration into tissues via a PKC signaling pathway...
  3. ncbi Glycogen synthase kinase-3: properties, functions, and regulation
    A Ali
    Division of Experimental Therapeutics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Chem Rev 101:2527-40. 2001
  4. ncbi Phosphorylation of HIV-1 gag proteins by protein kinase C
    B Burnette
    Laboratory of Biological Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:8698-703. 1993
    ..These data are consistent with the identification of a highly conserved consensus PKC phosphorylation site motif in the HIV-1 gag protein at Ser111 and suggests that PKC phosphorylation plays an important role in gag protein function...
  5. ncbi HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system
    H Idriss
    Sealy Center for Molecular Science, The University of Texas Medical Branch Galveston, TX 77555 0851, USA
    Int J Biochem Cell Biol 31:1443-52. 1999
    ..Our results indicate that purified HIV-1 RT can be phosphorylated by several mammalian protein kinases in vitro and during expression in baculovirus infected insect cells...
  6. ncbi A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Cell Immunol 137:1-13. 1991
    ....
  7. pmc Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
    K Conant
    Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    J Virol 70:1384-9. 1996
    ..These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor...
  8. pmc The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix
    S Swingler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 71:4372-7. 1997
    ..Recombinant p21-activated kinase hPAK65, a recently proposed relative of the Nef-associated kinase, achieved a comparable result. Taken together, these data suggest that MA is a target of the Nef-associated serine kinase...
  9. ncbi 14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells
    M V Autieri
    Department of Cardiology and Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    DNA Cell Biol 18:555-64. 1999
    ..Thus, 14-3-3gamma may represent a signal transduction protein that is regulated transcriptionally and post-transcriptionally by growth factors...
  10. ncbi Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation
    Susana Santos Correia
    Center for Neuroscience and Cell Biology and Department of Biochemistry, University of Coimbra, 3004 517 Coimbra, Portugal
    J Biol Chem 278:6307-13. 2003
    ..b>PKC gamma was co-immunoprecipitated with GluR4 AMPA receptor subunit in rat cerebellum and in cultured chick retina cell ..
  11. ncbi Regulation of HIV-1 gag protein subcellular targeting by protein kinase C
    G Yu
    Laboratory of Biological Chemistry, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255
    J Biol Chem 270:4792-6. 1995
    ..This signal may provide a mechanism for the cellular regulation of virus development through modulation of gag protein-related developmental steps such as capsid targeting, assembly, encapsidation, budding, and maturation...
  12. pmc HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?
    Giuseppe Nunnari
    University of Catania, Department of Medicine and Medical Specialties, Division of Infectious Diseases, Via Palermo 636, Catania, Italy
    J Exp Clin Cancer Res 27:3. 2008
    ..We propose that the Tat-induced DNA repair deficiencies may play a significant role in the development of AIDS-associated cancer...
  13. ncbi Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 144:3928-35. 1990
    ....
  14. pmc Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C
    A Jakobovits
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    EMBO J 9:1165-70. 1990
    ..Our results indicate that PKC regulates the process of HIV-1 transactivation, suggesting a key role for the mitogenic induction of trans-activation in the transition of HIV from latency to productive growth...
  15. pmc Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway
    A Badou
    Laboratoire d Immuno Virologie EA3038, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    J Virol 74:10551-62. 2000
    ..This production of IL-10 induced by Tat could participate in the progression of HIV infection to AIDS...
  16. ncbi Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine 92717
    Int J Immunopharmacol 16:197-204. 1994
    ..The most striking change was observed in PKC-zeta isozymes levels. This study for the first time demonstrates that HIV-1 gp120 affects calcium-independent PKC isozymes in U937 cells...
  17. ncbi In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46
    A M Holmes
    Biochemistry Department, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Arch Biochem Biophys 335:8-12. 1996
    ..Several Tat peptides, containing serine at position 46, are the only ones which are phosphorylated at significant rates. Several other Tat peptides containing potential protein kinase C phosphorylation sites are not phosphorylated...
  18. ncbi The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer
    C P Tseng
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9110, USA
    J Biol Chem 274:31981-6. 1999
    ..Taken together, these data suggest that PKC-regulated phosphorylation of DOC-2/DAB2 protein may help its growth inhibitory function...
  19. ncbi Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium
    M B Huang
    Department of Biochemistry, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Acquir Immune Defic Syndr 25:375-89. 2000
    ....
  20. ncbi Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C
    Flavia C Nery
    Centro de Biologia Molecular Estrutural, Laboratorio Nacional de Luz Sincrotron, Rua Giuseppe Máximo Scolfaro 10 000, C P 6192, 13084 971 Campinas, SP, Brasil
    J Biol Chem 279:11444-55. 2004
    ..These events associate Ki-1/57 with the RACK1/PKC pathway and may be important for the regulation of its cellular functions...
  21. pmc NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor
    María Rodríguez-Muñoz
    CIBER Mental Health CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain
    Antioxid Redox Signal 14:2413-25. 2011
    ..This study reveals new aspects of ERK1/2 regulation by the MOR without requiring the transactivation of a receptor tyrosine kinase...
  22. ncbi The identification of four protein kinase C isoforms in human glioblastoma cell lines: PKC alpha, gamma, epsilon, and zeta
    H Xiao
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio
    J Neurosurg 81:734-40. 1994
    ..These data suggest that alteration in the expression of PKC-epsilon and PKC-zeta could be a factor in the conversion of normal glial cells to glioblastomas...
  23. ncbi Characterization of patterns of expression of protein kinase C-alpha, -delta, -eta, -gamma and -zeta and their correlations to p53, galectin-3, the retinoic acid receptor-beta and the macrophage migration inhibitory factor (MIF) in human cholesteatomas
    Rose Ghanooni
    Department of Otolaryngology and Head and Neck Surgery, Erasmus University Hospital, 808 Route de Lennik, 1070 Brussels, Belgium
    Hear Res 214:7-16. 2006
    ....
  24. ncbi Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14
    Giovanni Stevanin
    INSERM U289, Institut Fédératif de Recherche en Neuroscience, Assistance Publique Hopitaux de Paris, Hôpital de al Salpêtrière, Paris, France
    Arch Neurol 61:1242-8. 2004
    ..Spinocerebellar ataxia type 14 (SCA14) is a relatively pure form of autosomal dominant cerebellar ataxia mapped to chromosome 19q and caused by missense ..
  25. ncbi Evidence for the interaction of protein kinase C and melanocortin 3-receptor signaling pathways
    S James Wachira
    Department of Biology, Morgan State University, Baltimore, MD 21251, USA
    Neuropeptides 37:201-10. 2003
    ..However, the levels of classical PKC isozymes, PKC-alpha, PKC-gamma, and PKC-beta were unchanged. These studies therefore indicate a role for PKC isozymes in gamma-2-MSH/MC3-R receptor signaling and in neuronal cell differentiation...
  26. ncbi Protein kinase C-gamma activation in the early streptozotocin diabetic rat lens
    Dingbo Lin
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    Curr Eye Res 32:523-32. 2007
    ..The purpose of this study is to demonstrate the early activation of the protein kinase C-gamma (PKC-gamma) pathway in the streptozotocin (STZ)-induced diabetic rat lens...
  27. ncbi Phosphorylation of HMG-I by protein kinase C attenuates its binding affinity to the promoter regions of protein kinase C gamma and neurogranin/RC3 genes
    D M Xiao
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Neurochem 74:392-9. 2000
    ..The current results suggest that phosphorylation of the mammalian HMG-I by PKC alone or in combination with cdc2 kinase provides an effective mechanism for the regulation of HMG-I function...
  28. ncbi Structure and regulation of the gene encoding the neuron-specific protein kinase C substrate neurogranin (RC3 protein)
    T Sato
    Section on Metabolic Regulation, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 270:10314-22. 1995
    ..A near homogeneous 20-kDa DNA-binding protein purified from rat brain was able to bind to these AT-rich regions of both Ng/RC3 and PKC-gamma genes with footprints containing ATTA, ATAA, and AATA sequences...
  29. ncbi Update on the molecular genetics of retinitis pigmentosa
    Q Wang
    Center for Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Ophthalmic Genet 22:133-54. 2001
    ..1-cen, RP1 on 8p11-21, RGR on 10q23, ROM1 on 11q13, NRL on 14q11.1-11.2, CRX on 19q13.3, and PRKCG on 19q13.4. Autosomal recessive genes include RPE65 on chromosome 1p31, ABCA4 on 1p21-13, CRB1 on 1q31-32...
  30. ncbi Regional and cellular distribution of protein kinase C in rat cerebellar Purkinje cells
    N H Barmack
    Neurological Sciences Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Comp Neurol 427:235-54. 2000
    ..These data identify circuitry that is unique to cerebellar-vestibular interactions...
  31. ncbi [Different roles of the spinal protein kinase C alpha and gamma in morphine dependence and naloxone-precipitated withdrawal]
    Jun Li Cao
    Department of Anesthesiology, Affiliated Hospital of First Clinical College, China Medical University, Shenyang 110001, China
    Sheng Li Xue Bao 57:161-8. 2005
    ..During morphine dependence, but not naloxone-precipitated withdrawal, PKC gamma in the spinal cord translocated from cytosol to membrane fraction, and intrathecal administration of CHE did not ..
  32. ncbi [Molecular genetic approach to spinocerebellar ataxias]
    Kinya Ishikawa
    Department of Neurology and Neurological Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Rinsho Shinkeigaku 49:907-9. 2009
    ..static mutations, such as missense mutations and deletions, have been identified to cause SCA5, SCA11, SCA13, SCA14, SCA15 and SCA27...
  33. ncbi Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice
    K P Zeitz
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143 0452, USA
    Pain 94:245-53. 2001
    ..that carry a null mutation in the gene encoding a neuronal specific isoform of protein kinase C (PKC), namely, PKC gamma. We used the tail-flick test to construct dose-response curves before and 4 days after chronic morphine (75-mg ..
  34. ncbi Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2
    K Buchet-Poyau
    Division of Medical Genetics, Geneva University Medical School, and University Hospitals, Geneva, Switzerland
    Cytogenet Genome Res 97:171-8. 2002
    ..Four genes in the region (cytohesin 2: PSCD2, kallikrein 10: KLK10, protein kinase C gamma: PRKCG, and serine/threonine kinase 13: STK13) potentially involved in growth inhibitory pathways or in the ..
  35. ncbi Congo red, an amyloid-inhibiting compound, alleviates various types of cellular dysfunction triggered by mutant protein kinase cγ that causes spinocerebellar ataxia type 14 (SCA14) by inhibiting oligomerization and aggregation
    Takahiro Seki
    Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    J Pharmacol Sci 114:206-16. 2010
    ..missense mutations in the protein kinase Cγ (γPKC) gene have been found to cause spinocerebellar ataxia type 14 (SCA14), an autosomal dominant neurodegenerative disease...
  36. ncbi Activity-dependent distribution of protein kinase C-delta within rat cerebellar Purkinje cells following unilateral labyrinthectomy
    N H Barmack
    Neurological Sciences Institute, Oregon Health Sciences University West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Exp Brain Res 141:6-20. 2001
    ..We conclude that both PKC-delta and PKC-gamma are constitutively expressed in Purkinje cells. The targeting of PKC-delta, but not PKC-gamma, to Purkinje neuron synaptic terminals is influenced by activity...
  37. ncbi Characterization of the 5'-flanking region of the rat protein kinase C gamma gene
    K H Chen
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 265:19961-5. 1990
    ..using HeLa cell nuclear extracts and chloramphenicol acetyltransferase assay by transfection of 293 cells with a PKC gamma-CAT fusion construct. Chloramphenicol acetyltransferase assay revealed that a fragment of about 0...
  38. pmc Altered trafficking of membrane proteins in purkinje cells of SCA1 transgenic mice
    P J Skinner
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Pathol 159:905-13. 2001
    ....
  39. ncbi The hereditary spinocerebellar ataxias in Japan
    H Sasaki
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Cytogenet Genome Res 100:198-205. 2003
    ..From this cluster, pure cerebellar ataxias linked with the SCA4, SCA14, and SCA16 locus have been isolated. Among the recessive SCAs, patients with AVED and EAOH have been detected...
  40. ncbi Dilinoleoyl-phosphatidylethanolamine from Hericium erinaceum protects against ER stress-dependent Neuro2a cell death via protein kinase C pathway
    Kaoru Nagai
    Department of Epigenetic Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, Japan
    J Nutr Biochem 17:525-30. 2006
    ..The protecting activity of DLPE was attenuated in the presence of a PKC inhibitor GF109203X but not completely diminished. Therefore, DLPE can protect neuronal cells from ER stress-induced cell death, at least in part by the PKC pathway...
  41. doi Clinical and genetic analysis of spinocerebellar ataxia type 11
    Janel Johnson
    Neurogenetics, Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Cerebellum 7:159-64. 2008
    ..At present 3 ADCA type III SCA genes have been published, SCA5, SCA6, and SCA14, these three genes appear to have various roles suggesting involvement in both different and possibly overlapping ..
  42. doi A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy
    Eisuke Adachi
    Department of Physiology, Hamamatsu University School of Medicine, Handa yama 1 20 1, Higashi ku, Hamamatsu, Shizuoka, 431 3192, Japan
    Pflugers Arch 459:227-34. 2009
    ..indicator, as a cAMP sensor; and (3) C1-tagged monomeric red fluorescent protein, a tandem DAG-binding domain of PKC gamma, as a DAG sensor or myristoylated alanine-rich C kinase substrate-tagged DsRed for the PKC activation pathway...
  43. ncbi Autoregulation of cloned human protein kinase C beta and gamma gene promoters in U937 cells
    J Mahajna
    Ludwig Institute for Cancer Research, London, UK
    DNA Cell Biol 14:213-22. 1995
    ..The transcription initiation site of the PKC gamma gene was identified by primed cDNA synthesis...
  44. ncbi Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion
    Shohei Matsumoto
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    J Cereb Blood Flow Metab 24:54-61. 2004
    ..Drugs preventing PKC and/or CaMKII-alpha translocation may prove beneficial against ischemic cell death...
  45. pmc Protein kinase C group B members PKC-delta, -epsilon, -zeta and PKC-L(eta). Comparison of properties of recombinant proteins in vitro and in vivo
    M Liyanage
    Max Delbrück Laboratorium, Max Planck Gesellschaft, Koln, Germany
    Biochem J 283:781-7. 1992
    ..Consistent with their ability to bind phorbol ester, recombinant PKC-delta and PKC-epsilon are down-regulated in COS cells by prolonged treatment with phorbol ester, whereas PKC-zeta protein levels remain unaltered...
  46. ncbi Genetic linkage mapping of the dehydroepiandrosterone sulfotransferase (STD) gene on the chromosome 19q13.3 region
    F Durocher
    Medical Research Group in Molecular Endocrinology, CHUL Research Center, Laval, Quebec, Canada
    Genomics 29:781-3. 1995
    ..Thereafter, a high-resolution genetic map of the region was constructed, yielding to the following order: qter-D19S414-D19S224-D19S420-D19S217-(APOC2++ +-D19S412)- (STD-HRC)-KLK-D19S22-D19S180-PRKCG-D19S418 -tel.
  47. ncbi Increased neuronal and glial expression of protein kinase C isoforms in neocortex of transgenic Tg2576 mice with amyloid pathology
    S Rossner
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, Jahnallee 59, 04109 Leipzig, Germany
    Eur J Neurosci 13:269-78. 2001
    ..Using specific antibodies to PKC alpha, PKC beta, PKC gamma, PKC epsilon and PKC zeta isoforms for Western blot analysis, we observed increased immunoreactivity for PKC ..
  48. ncbi Age-dependent activation of PKC isoforms by angiotensin II in the proximal nephron
    D M Boesch
    Division of Hypertension and Vascular Research, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Am J Physiol Regul Integr Comp Physiol 281:R861-7. 2001
    ..05). Maximum specific binding and affinity of ANG II receptors were not significantly different between young and adult rats. We concluded that the primary PKC isoform activated by ANG II changes during maturation...
  49. ncbi The effects of antiepileptic drugs on spatial learning and hippocampal protein kinase C gamma in immature rats
    Ye Wu
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, PR China
    Brain Dev 24:82-7. 2002
    ..05) than in the PB, CBZ and VPA group. The PKC gamma staining intensity in hippocampal CA1-2 region of training group was significant greater than that of the ..
  50. ncbi Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice
    W R Proctor
    Department of Veterans Affairs Medical Center, Research Service, Denver, Colorado, USA
    J Pharmacol Exp Ther 305:264-70. 2003
    ..These results suggest that PKCgamma and PKCepsilon signaling pathways reciprocally modulate both ethanol enhancement of GABA(A) receptor function and hypnotic sensitivity to ethanol...
  51. ncbi Influence of a deletion of protein kinase C gamma isoform in the G-protein activation mediated through opioid receptor-like-1 and mu-opioid receptors in the mouse pons/medulla
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara Shinagawa Ku, Tokyo 142 8501, Japan
    Neurosci Lett 331:5-8. 2002
    ..study was to investigate whether mice with a deletion of the gene that encodes the protein kinase C gamma (PKC gamma) isoform could affect the G-protein activation mediated through the opioid receptor-like (ORL-1) receptor and mu-..
  52. pmc Effect of trehalose on the properties of mutant {gamma}PKC, which causes spinocerebellar ataxia type 14, in neuronal cell lines and cultured Purkinje cells
    Takahiro Seki
    Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    J Biol Chem 285:33252-64. 2010
    ..missense mutations in the protein kinase Cγ (γPKC) gene have been found to cause spinocerebellar ataxia type 14 (SCA14), an autosomal dominant neurodegenerative disease...
  53. pmc ZO-1 is required for protein kinase C gamma-driven disassembly of connexin 43
    Vladimir Akoyev
    Department of Biochemistry, 141 Chalmers Hall, Kansas State University, Manhattan, Kansas 66506, United States
    Cell Signal 19:958-67. 2007
    ..These results suggest that ZO-1 is required for Cx43 control, both for dye transfer, and, for the PKC-gamma-driven disassembly response...
  54. doi The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection
    Sandra Espada
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Instituto de Investigaciones Biomédicas Alberto Sols UAM CSIC, Universidad Autonoma de Madrid, Madrid, Spain
    J Neurochem 110:1107-19. 2009
    ..Such role provides additional conceptual support for the use of cholinemimetics in the treatment of pathologies that, like Alzheimer's disease, require a reinforcement of the cell antioxidant capacity...
  55. doi Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats
    S Furuta
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
    Neuroscience 164:1252-62. 2009
    ..Furthermore, this chronic muscle pain may result from nociceptive neuroplasticity of the spinal cord dorsal horn...
  56. ncbi A filarial nematode secreted product differentially modulates expression and activation of protein kinase C isoforms in B lymphocytes
    M R Deehan
    Department of Immunology, University of Strathclyde, Glasgow, UK
    J Immunol 159:6105-11. 1997
    ..Phosphorylcholine-containing secreted products (phosphorylcholine-ES) are also released by human filarial parasites; hence we discuss how these findings may relate to the nature of the human B cell response during filarial infections...
  57. ncbi Exposure to lead elevates induction of zif268 and Arc mRNA in rats after electroconvulsive shock: the involvement of protein kinase C
    Kyung Ah Kim
    Department of Environmental Health Sciences, School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    J Neurosci Res 69:268-77. 2002
    ..An increase in the amount of PKC epsilon and PKC gamma was observed at 60 min after ECS in the membrane fraction from hippocampus, indicating activation of these ..
  58. pmc Gelsolin suppresses tumorigenicity through inhibiting PKC activation in a human lung cancer cell line, PC10
    N Sagawa
    Division of Cancer Gene Regulation, Research Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Br J Cancer 88:606-12. 2003
    ..did not increase inositoltriphosphate (IP3) production and induce the membrane fractions of PKC alpha and PKC gamma in gelsolin tranfectants, while it induced PIP2 hydrolysis and increased the fractions in parental and control ..
  59. ncbi Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of protein kinase C in chick and avian models
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy, and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Ann N Y Acad Sci 1025:595-601. 2004
    ..to the eggs (20 mg/kg) on incubation days 0 and 5 diminished the post-hatch imprinting ability and reduced PKCg and bII content in the IMHV membrane fraction...
  60. ncbi Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia
    Guoxiang Yuan
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 280:4321-8. 2005
    ..These observations suggest that IH induces HIF-1 transcriptional activity via a novel signaling pathway involving CaM kinase...
  61. ncbi Spinocerebellar ataxia 14: novel mutation in exon 2 of PRKCG in a German family
    Dagmar Nolte
    Institut fur Humangenetik, Justus Liebig Universitat Giessen, Germany
    Mov Disord 22:265-7. 2007
    We describe a novel mutation in the gene coding for protein kinase C gamma (PRKCG) in patients of a German family affected with slowly progressive gait ataxia, dysarthria, and nystagmus...
  62. doi Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains
    Shohei Matsumoto
    Department of Anesthesiology, Tokyo Medical University Hospital, Nishishinjuku 6 7 1, Shinjuku ku, Tokyo, 160 0023, Japan
    Neurochem Res 33:2302-9. 2008
    ..These results may explain in part the cellular and molecular mechanisms of neuroprotective effects of isoflurane...
  63. ncbi Genetic maps of polymorphic DNA loci on rat chromosome 1
    Y P Ding
    Arthritis and Rheumatism Branch, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Genomics 36:320-7. 1996
    ..Thirteen gene loci (Myl2, Aldoa, Tnt, Igf2, Prkcg, Cgm4, Calm3, Cgm3, Psbp1, Sa, Hbb, Ins1, and Tcp1) were previously mapped...
  64. ncbi Mapping of the SCA23 locus involved in autosomal dominant cerebellar ataxia to chromosome region 20p13-12.3
    D S Verbeek
    Department of Biomedical Genetics, Stratenum 2 112, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, The Netherlands
    Brain 127:2551-7. 2004
    ..In addition to the recently identified SCA14, SCA19 and FGF14 families, SCA23 is yet another novel SCA locus in the Dutch ADCA population, which further ..
  65. ncbi NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions
    R X Xu
    Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 36:10709-17. 1997
    ..The data also suggest that half of the domain, including the phorbol site and one of the zinc sites, is capable of inserting into membranes...
  66. ncbi Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains
    E A Clark
    Cell Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia
    Lab Invest 64:35-44. 1991
    ..Using monoclonal antibodies to PKC alpha, PKC beta, and PKC gamma isozymes, we (a) determined the distribution of each PKC isozyme in eight different brain regions (cerebellum, ..
  67. ncbi The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C
    T Herget
    Institute of Physiological Chemistry, University of Mainz, Germany
    Eur J Biochem 233:448-57. 1995
    ..There was no dramatic difference in the sequential phosphorylation of MARCKS detectable when comparing the four PKC isotypes. The results are discussed in the context of the functional significance of MARCKS phosphorylation...
  68. ncbi Functional characterization of the promoter region of the mouse protein kinase C gamma gene
    H Takanaga
    Department of Biology, Faculty of Science, Kobe University, Japan
    FEBS Lett 368:276-8. 1995
    ..from the cells transfected with various fusion constructs containing the 5'-flanking region of the mouse PKC gamma gene and CAT gene...
  69. ncbi Modified hippocampal long-term potentiation in PKC gamma-mutant mice
    A Abeliovich
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Cell 75:1253-62. 1993
    ..We propose that PKC gamma is not part of the molecular machinery that produces LTP but is a key regulatory component.
  70. ncbi PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning
    A Abeliovich
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Cell 75:1263-71. 1993
    ..We have generated mice deficient in the gamma isoform of protein kinase C (PKC gamma), an enzyme that has previously been implicated in both long-term potentiation (LTP) and learning and memory...
  71. ncbi Spinocerebellar mossy fiber terminal topography in the NR2C/PKC gamma double mutant cerebellum
    Z Ji
    Maryland Psychiatric Research Center University of Maryland Medical School, Baltimore 21228, USA
    Brain Res Dev Brain Res 97:138-42. 1996
    The spatiotemporal expression patterns of the NR2C subunit of the NMDA receptor and PKC gamma isoform during cerebellar development suggests that both proteins are involved in the molecular mechanisms of synaptogenesis...
  72. ncbi Incomplete regression of multiple climbing fibre innervation of cerebellar Purkinje cells in mGLuR1 mutant mice
    C Levenes
    Laboratoire de Neurobiologie, CNRS, Orsay, France
    Neuroreport 8:571-4. 1997
    ..of multiple climbing fibre innervation and impaired motor coordination in protein kinase C gamma subunit (PKC gamma) mutant mice...
  73. ncbi Comparative mapping of anchor loci from HSA19 to cattle chromosomes 7 and 18
    Q Gao
    Department of Veterinary Pathobiology, Texas A and M University, College Station 77843, USA
    J Hered 88:524-7. 1997
    Six loci--CALR, EPOR, JUNB, JUND, CEA, and PRKCG--were assigned to bovine chromosomes using PCR-based hybrid somatic cell analysis. The five genes other than CALR are comparative mapping anchor loci...
  74. ncbi Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals
    E Oancea
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 95:307-18. 1998
    ..The properties of this molecular decoding machine make PKCgamma responsive to persistent diacylglycerol increases combined with high- but not low-frequency calcium spikes...
  75. ncbi Protein kinase C-alpha isoform is involved in erythropoietin-induced erythroid differentiation of CD34(+) progenitor cells from human bone marrow
    J H Myklebust
    Department of Immunology, The Norwegian Radium Hospital, Oslo, Norway
    Blood 95:510-8. 2000
    ..Taken together, these findings point to a novel role for the PKC-alpha isoform in mediating EPO-induced erythroid differentiation of the CD34(+) progenitor cells from human bone marrow. (Blood. 2000;95:510-518)..
  76. pmc Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication
    P D Lampe
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Cell Biol 149:1503-12. 2000
    ..These data strongly suggest that PKC directly phosphorylates Cx43 on S368 in vivo, which results in a change in single channel behavior that contributes to a decrease in intercellular communication...
  77. ncbi Gender influences the effect of perinatal copper deficiency on cerebellar PKC gamma content
    W T Johnson
    United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, ND 58202 9034, USA
    Biofactors 11:163-9. 2000
    ..However, it is not clear whether suppression of PKCgamma by perinatal Cu deficiency produces permanent neuropathology in the cerebellum because the effects were reversed by Cu supplementation...
  78. ncbi Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development
    G Balasubramanian
    Department of Veterinary Biomedical Sciences, University of Missouri Columbia, 65211, USA
    J Craniofac Genet Dev Biol 20:26-34. 2000
    ..0, which gradually decreased through GD 14.5, whereas PKC betaI and PKC gamma were negligible throughout...
  79. pmc Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
    X Fang
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:11960-5. 2000
    ....
  80. ncbi [Signaling pathways regulating the expression of proteases during tumor progression]
    E B de Kier Joffe
    Instituto de Oncologia Angel H Roffo, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Medicina (B Aires) 60:34-40. 2000
    ..Overexpression of PKC gamma in normal mammary epithelial cells or of v-Src and v-Ras in NIH3T3 fibroblasts induced in all cases ..
  81. ncbi HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta
    Yamina Bennasser
    Laboratoire d Immuno Virologie, EA 3038, Universite Paul Sabatier, 31062 Toulouse, France
    FASEB J 16:546-54. 2002
    ..Altogether, these results suggest that the induction of IL-10 by Tat is strictly dependent on the PKC-delta and -betaII isoforms...
  82. pmc PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments
    Yong Qian
    The Mary Babb Randolph Cancer Center and the Department of Microbiology and Immunology, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    Mol Biol Cell 13:2311-22. 2002
    ....
  83. ncbi Helicobacter pylori -induced apoptosis in gastric epithelial cells is blocked by protein kinase C activation
    Barbara Obst
    Department of Pharmacology, Hannover Medical School, D 30625 Hannover, Germany
    Microb Pathog 33:167-75. 2002
    ..The PKC activator 12- O -tetradecanoylphorbol-13-acetate (TPA) caused translocation of PKC gamma, delta and var epsilon, prevented H. pylori -induced caspase activation and programmed cell death...
  84. pmc Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells
    Robert Delsite
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Room 143, Baltimore, MD 21231, USA
    Mol Cancer 1:6. 2002
    ..Mutations in mitochondrial genes encoding the 13 subunits have been reported in a variety of cancers. However, little is known about the nuclear response to impairment of mitochondrial function in human cells...
  85. ncbi Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity
    Shannon Glaser
    Department of Internal Medicine, Texas A and M University System Health Sciences Center, College of Medicine, Temple, Texas 76504, USA
    Am J Physiol Gastrointest Liver Physiol 284:G683-94. 2003
    ..The dopaminergic nervous system counterregulates secretin-stimulated ductal secretion in experimental cholestasis...
  86. ncbi Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein
    Kevin C Corbit
    Department of Neurobiology, Pharmacology and Physiology, and Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:13061-8. 2003
    ..Taken together, these results constitute the first model showing how phosphorylation by PKC relieves a key inhibitor of the Raf/MAP kinase signaling cascade and may represent a general mechanism for the regulation of MAP kinase pathways...
  87. ncbi Serotonin transport is modulated differently by tetanus toxin and growth factors
    Carles Gil
    Departament de Bioquimica i de Biologia Molecular, Institut de Neurociencies, Universitat Autonoma de Barcelona, E 08193 Cerdanyola del Vallès, Barcelona, Spain
    Neurochem Int 42:535-42. 2003
    ..b>PKC gamma, delta, and epsilon isoforms are equally activated by both compounds, whereas the beta isoform is activated in a ..
  88. ncbi Alterations in brain protein kinase C isoforms following developmental exposure to a polychlorinated biphenyl mixture
    Jae Ho Yang
    National Academy of Sciences, National Research Council, Washington, DC, USA
    Brain Res Mol Brain Res 111:123-35. 2003
    ..It is believed that this is the first report successfully identifying PKC isoforms responding to PCBs during developmental exposure...
  89. ncbi Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2
    Kristina Lorenz
    Institut fur Pharmakologie und Toxikologie, Versbacher Strasse 9, D 97078 Wurzburg, Germany
    Nature 426:574-9. 2003
    ..A physiological role for this mechanism is shown in cardiomyocytes in which the downregulation of RKIP restrains beta-adrenergic signalling and contractile activity...
  90. ncbi Protein kinases expressed by interstitial cells of Cajal
    Daniel P Poole
    Department of Anatomy and Cell Biology and Centre for Neuroscience, University of Melbourne, VIC 3010 Parkville, Australia
    Histochem Cell Biol 121:21-30. 2004
    ..This study has demonstrated the immunohistochemical localisation of PKA, PKC gamma and PKC theta in ICC that were identified by the known ICC marker, c-Kit, in the guinea-pig gut...
  91. ncbi Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: Relationship between its expression and prognosis
    Katsuhito Kamimura
    First Department of Pathology, Fukushima Medical University School of Medicine, Hikariga oka, Fukushima, Japan
    Pathol Int 54:224-30. 2004
    ..The expression of PKC gamma was observed in only five cases of BL...
  92. ncbi Inhibition of spinal protein kinase C-epsilon or -gamma isozymes does not affect halothane minimum alveolar anesthetic concentration in rats
    Jennifer A Shumilla
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    Anesth Analg 99:82-4. 2004
    ....
  93. ncbi Acute restraint stress reduces protein kinase C gamma in the hippocampus of C57BL/6 but not DBA/2 mice
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Medical Science Building, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    Neurosci Lett 368:293-6. 2004
    Protein kinase C gamma (PKC gamma) is highly expressed in the rodent hippocampus and has been implicated in long-term alterations in synaptic efficacy...
  94. ncbi Inhibition of gap junction activity through the release of the C1B domain of protein kinase Cgamma (PKCgamma) from 14-3-3: identification of PKCgamma-binding sites
    Thu Annelise Nguyen
    Department of Biochemistry and Division of Biology, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 279:52714-25. 2004
    ..This demonstrates that synthetic peptides can be used to exogenously regulate gap junctions...
  95. ncbi Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an
    Michal Izrael
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neurosci Res 78:499-507. 2004
    ..e., not mediated by maternal confounds. The chick thus provides a suitable model for the rapid screening of neuroteratogens and elucidation of the mechanisms underlying behavioral anomalies...
  96. ncbi Chronic exposure to ammonia induces isoform-selective alterations in the intracellular distribution and NMDA receptor-mediated translocation of protein kinase C in cerebellar neurons in culture
    Gennaro Giordano
    Laboratory of Neurobiology, Fundacion Valenciana de Investigaciones Biomédicas Valencia, Spain
    J Neurochem 92:143-57. 2005
    ..NMDA-induced translocation of PKC alpha and beta is prevented by ammonia, whereas PKC gamma, delta, epsilon, or theta; translocation is not affected...
  97. ncbi Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta
    L aurelle A Johnson
    Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 0632, USA
    J Biol Chem 280:10914-9. 2005
    ..PKC beta(I) and PKC beta(II), but not PKC alpha or PKC gamma, were co-immunoprecipitated from rat striatal membranes with the dopamine transporter (DAT)...
  98. ncbi PKC isoforms were reduced by lead in the developing rat brain
    Shang Zhi Xu
    Department of Biological Sciences, Alcorn State University, 1000 ASU Drive, P O Box 870, Alcorn State, MS 39096, USA
    Int J Dev Neurosci 23:53-64. 2005
    ....
  99. ncbi Activation of PKC modulates blood-brain barrier endothelial cell permeability changes induced by hypoxia and posthypoxic reoxygenation
    Melissa A Fleegal
    Dept of Medical Pharmacology, College of Medicine, The Univ of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Am J Physiol Heart Circ Physiol 289:H2012-9. 2005
    ..These data demonstrate that hypoxia-induced BBB paracellular permeability changes occur via a PKC-dependent mechanism, possibly by differentially regulating the protein expression of the 11 PKC isozymes...
  100. ncbi TCDD alters PKC signaling pathways in developing neuronal cells in culture
    Sun Young Kim
    Department of Pharmacology Toxicology, Catholic University of Daegu, School of Medicine, Daegu, Republic of Korea
    Chemosphere 67:S421-7. 2007
    ....
  101. ncbi Spectrum and prevalence of autosomal dominant spinocerebellar ataxia in Hokkaido, the northern island of Japan: a study of 113 Japanese families
    Rehana Basri
    Department of Neurology, Graduate School of Medicine, Hokkaido University, N15W7 Kita ku, Sapporo 060 8368, Japan
    J Hum Genet 52:848-55. 2007
    ..have the mutation associated with SCA6, 30 with SCA3, 11 with SCA1, five with SCA2, five with DRPLA, and one with SCA14. We also detected the heterozygous -16C --> T single nucleotide substitution within the puratrophin-1 gene ..

Research Grants25

  1. Role of Protein Kinase C regulatory domains in modulating alcohol actions
    Joydip Das; Fiscal Year: 2010
    ..significant decrease in alcohol consumption and increase in tolerance to ethanol compared to wild type mice, the PKC gamma knock-outs showed significant increase in alcohol consumption and decrease in tolerance...
  2. Frederick Southwick; Fiscal Year: 2014
    ..These discoveries can be applied to all forms of cell motility, including tumor metastasis, neurite outgrowth, and platelet spreading. ..
  3. Andre Limnander; Fiscal Year: 2014
    ..This pathway requires PKC[unreadable] and RasGRP proteins and loss of this pathway in PKCg-deficient mice results in increased survival of B cells during negative selection and subsequent development of an ..
  4. Lyso-PCs activate PMNs and endothelium via PKC
    CHRISTOPHER SILLIMAN; Fiscal Year: 2006
    ..determine the signaling pathways of lyso-PCs from its receptor to its effector kinases; 2) to confirm the that PKC gamma is the effector kinase in lyso-PC mediated signaling; 3) to determine the role of PKC activation in PMNs and ..
  5. Function and Modulation of Somatic and Dendritic Kv3.3 Channels in Purkinje Cells
    Edward Zagha; Fiscal Year: 2007
    ..3 is an important mechanism in the cellular effects of PKC. Moreover, mutations in PKC gamma are the cause of human spinocerebellar ataxia SCA14. Thus, mutations in either Kv3...
  6. PKC Cys switches -- novel cancer prevention targets
    CATHERINE O BRIAN; Fiscal Year: 2006
    ....
  7. 5-HT2 and 5-HT1A Receptors in PKC-gamma Null Mutant Mice
    Barbara Bowers; Fiscal Year: 2005
    ..The results of these studies will help to elucidate the specific role of PKCgamma, in complex behaviors associated with alcohol dependence. ..
  8. EXPRESSION OF PROTEIN KINASE C IN LENS EPITHELIAL CELLS
    Karen Gonzalez; Fiscal Year: 1999
    ..Enhancing the awareness of our students to continue graduate studies in Cellular and Molecular Biology will also be assessed. ..
  9. Structure Function Studies Of Membrane Binding Proteins
    Wonhwa Cho; Fiscal Year: 2004
    ....
  10. RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEM
    NEAL BARMACK; Fiscal Year: 2003
    ..abstract_text> ..
  11. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2005
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  12. Alcohol Modulation of Cerebellar Synaptic Currents
    William Proctor; Fiscal Year: 2006
    ..The combination of our proposed and ongoing genetic studies may aid the identification of more sensitive drug targets and the development of novel drugs for rational therapeutic approaches to alcoholism. ..
  13. Presenilins and neuronal calcium signaling
    ILYA B BEZPROZVANNY; Fiscal Year: 2010
    ..These data will also help to evaluate "Ca2+ hypothesis of AD" and will contribute to selecting optimal strategies for treatment of AD. ..
  14. Structure-function of inositol trisphosphate receptor
    Ilya Bezprozvanny; Fiscal Year: 2009
    ..Dopamine-induced responses in striatal medium spiny neurons will be studied by Ca2+ imaging. Experiments with striatal neurons from DARPP-32 and D2 receptor knockout mice will be performed. ..
  15. HTS Screen for Small Molecule Inhibitors of Mint-PDZ Domain
    Ilya Bezprozvanny; Fiscal Year: 2008
    ..Generated molecules may also serve as useful probes for studies of synaptic function of N-type Ca2+ channels. [unreadable] [unreadable] [unreadable]..
  16. 2008 Calcium Signaling and Disease SGP Conference
    Ilya Bezprozvanny; Fiscal Year: 2008
    ..The major purpose of the SGP is to host a symposium each year on a different subject of wide interest to cell biologists, physiologists and biophysicists. [unreadable] [unreadable] [unreadable]..
  17. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
    ..The proposed experiments are innovative and exploratory in that the effect of altered DHA concentrations on PKC and dopamine D2 receptor expression have not been systematically examined in brain. [unreadable] [unreadable] [unreadable]..
  18. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  19. Molecular Mechanisms of Cardiac Arrhythmias
    Qing Wang; Fiscal Year: 2005
    ..These studies may provide a new framework for the rational design of therapeutic agents. ..
  20. Screen:Blockers of a CaV2.2-Mint-PDZ1 association (RMI)
    Ilya Bezprozvanny; Fiscal Year: 2004
    ..Biological activity of compounds identified in the full HTS screen will be tested in whole animal pain assays (formalin, hot plate, tail flick). ..
  21. Molecular Determinants of Coronary Artery Disease
    Qing Wang; Fiscal Year: 2004
    ..The accomplishment of research objectives in this proposal has the potential to have a substantial impact on the understanding of the molecular mechanism of CAD and MI, thereby facilitating better prevention, diagnosis and therapy. ..
  22. Mechanisms of Myocardial Radiofrequency Scar Expansion
    Rupak Mukherjee; Fiscal Year: 2004
    ..abstract_text> ..
  23. INTERACTIONS OF CALCIUM CHANNELS WITH ADAPTOR PROTEINS
    Ilya Bezprozvanny; Fiscal Year: 2003
    ....
  24. GENES FOR VASCULAR MORPHOGENESIS: A GENETIC APPROACH
    Qing Wang; Fiscal Year: 2003
    ..Moreover, understanding the genetic mechanisms underlying KTS offers possibilities for treatment of KTS as well as conditions such as cancer that depend on angiogenesis. ..
  25. Proteomic Biomarkers of Health Behaviors
    Paul Lampe; Fiscal Year: 2005
    ..abstract_text> ..