Gene Symbol: PRKAR1A
Description: protein kinase cAMP-dependent type I regulatory subunit alpha
Alias: ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1, cAMP-dependent protein kinase type I-alpha regulatory subunit, Carney complex type 1, cAMP-dependent protein kinase regulatory subunit RIalpha, cAMP-dependent protein kinase type I-alpha regulatory chain, protein kinase A type 1a regulatory subunit, protein kinase, cAMP-dependent, regulatory subunit type I alpha, protein kinase, cAMP-dependent, regulatory, type I, alpha, tissue-specific extinguisher 1
Species: human
Products:     PRKAR1A

Top Publications

  1. Greene E, Horvath A, Nesterova M, Giatzakis C, Bossis I, Stratakis C. In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay. Hum Mutat. 2008;29:633-9 pubmed publisher
    ..subunit (RIalpha) of adenosine 3',5'-cyclic monophosphate (cyclic AMP [cAMP])-dependent protein kinase (PKA; PRKAR1A)...
  2. Kopperud R, Christensen A, Kjarland E, Viste K, Kleivdal H, Døskeland S. Formation of inactive cAMP-saturated holoenzyme of cAMP-dependent protein kinase under physiological conditions. J Biol Chem. 2002;277:13443-8 pubmed
    ..This could be explained by enhanced ternary complex formation. Modulation of ternary complex formation by the level of R subunit may represent a novel way of regulating the cAMP kinase activity in maximally cAMP-stimulated cells. ..
  3. Horvath A, Bertherat J, Groussin L, Guillaud Bataille M, Tsang K, Cazabat L, et al. Mutations and polymorphisms in the gene encoding regulatory subunit type 1-alpha of protein kinase A (PRKAR1A): an update. Hum Mutat. 2010;31:369-79 pubmed publisher
    b>PRKAR1A encodes the regulatory subunit type 1-alpha (RIalpha) of the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA)...
  4. Gibson R, Taylor S. Dissecting the cooperative reassociation of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Role of Trp-196 in the catalytic subunit. J Biol Chem. 1997;272:31998-2005 pubmed
    ..One of these mutants, rR(R333K), having a defect in cAMP binding site B formed a stable complex with rC(W196R) in the absence of cAMP. However, unlike wild-type holoenzyme, this complex was active. ..
  5. Zimmermann B, Chiorini J, Ma Y, Kotin R, Herberg F. PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I. J Biol Chem. 1999;274:5370-8 pubmed
    ..We discuss how PrKX can modulate the cAMP-mediated signal transduction pathway by preferential binding to the RIalpha subunit and by phosphorylating the RIIalpha subunit in the absence of cAMP. ..
  6. Dao K, Teigen K, Kopperud R, Hodneland E, Schwede F, Christensen A, et al. Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. J Biol Chem. 2006;281:21500-11 pubmed
    ..This helped explain the specificity of current cAMP analogs and, more importantly, lays a foundation for the generation of even more discriminative analogs. ..
  7. Pajares M, Rojo A, Arias E, Díaz Carretero A, Cuervo A, Cuadrado A. Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Autophagy. 2018;14:1310-1322 pubmed publisher
    ..ACTB: actin, beta, ARE: antioxidant response element; ATG5: autophagy related 5; BACH1: BTB domain and CNC homolog 1; ChIP: chromatin immunoprecipitation; CMA: chaperone-mediated autophagy; DHE: dihydroethidium; DMF: ..
  8. Liu Y, Lu F, Kang L, Wang Z, Wang Y. Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium. BMC Pulm Med. 2017;17:63 pubmed publisher
    ..equilibrium of Nuclear factor-erythroid-related factor 2 (Nrf2)/[BTB (broad-complex, tramtrack and bric-a-brac) and CNC (cap'n'collar protein) homology 1, Bach1] determines the expression level of antioxidant factors, further ..
  9. Kishimoto D, Kirino Y, Tamura M, Takeno M, Kunishita Y, Takase Minegishi K, et al. Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons. Arthritis Res Ther. 2018;20:64 pubmed publisher
    ..Effects of type I interferons on the expression levels of CD163, HO-1, BTB and CNC homology 1 (Bach1; a transcriptional HO-1 repressor), interleukin (IL)-6, and IL-10 by human M2-like Mϕ, which ..

More Information

Publications142 found, 100 shown here

  1. Mondal N, Saha H, Mukherjee B, Tyagi N, Ray M. Inflammation, oxidative stress, and higher expression levels of Nrf2 and NQO1 proteins in the airways of women chronically exposed to biomass fuel smoke. Mol Cell Biochem. 2018;447:63-76 pubmed publisher
    ..nuclear factor erythroid 2 [NF-E2]-related factor 2 [Nrf2]), Keap1 (Kelch-like erythroid-cell-derived protein with CNC homology [ECH]-associated protein 1), and NQO1 (NAD(P)H:quinone oxidoreductase 1) proteins in the airways...
  2. Abolaji A, Kamdem J, Lugokenski T, Farombi E, Souza D, da Silva Loreto É, et al. Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4-vinylcyclohexene diepoxide disrupt redox status and modify different electrophile sensitive target enzymes and genes in Drosophila melanogaster. Redox Biol. 2015;5:328-339 pubmed publisher
    ..of the genes encoding the proteins superoxide dismutase (SOD1), kelch-like erythroid-derived cap-n-collar (CNC) homology (ECH)-associated protein 1 (Keap-1), mitogen activated protein kinase 2 (MAPK-2), catalase, Cyp18a1, ..
  3. Takada T, Miyaki S, Ishitobi H, Hirai Y, Nakasa T, Igarashi K, et al. Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1. Arthritis Res Ther. 2015;17:285 pubmed publisher
    BTB and CNC homology 1 (Bach1) is a transcriptional repressor of Heme oxygenase-1 (HO-1), which is cytoprotective through its antioxidant effects...
  4. Alband N, Korbonits M. Familial pituitary tumors. Handb Clin Neurol. 2014;124:339-60 pubmed publisher
    ..include the MEN1 gene, responsible for about 80% of MEN1 cases, the regulatory subunit of the protein kinase A, PRKAR1A, responsible for about 70% of Carney complex cases, and AIP, the gene coding the aryl hydrocarbon receptor ..
  5. Williams L, Lago B, McArthur A, Raphenya A, Pray N, Saleem N, et al. The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development. Aquat Toxicol. 2016;180:141-154 pubmed publisher
    ..In response to pro-oxidant exposure, members of the Cap'n'Collar (CNC) basic leucine zipper (b-ZIP) transcription factor family (including Nfe2 and Nfe2-related factors, Nrfs) activate ..
  6. Panya A, Thepmalee C, Sawasdee N, Sujjitjoon J, Phanthaphol N, Junking M, et al. Cytotoxic activity of effector T cells against cholangiocarcinoma is enhanced by self-differentiated monocyte-derived dendritic cells. Cancer Immunol Immunother. 2018;67:1579-1588 pubmed publisher
    ..dendritic cells (SD-DC) presenting cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A), which is an overexpressed protein that plays a role in the regulation of tumor growth to activate T cells for ..
  7. Hachani A, Lossi N, Filloux A. A visual assay to monitor T6SS-mediated bacterial competition. J Vis Exp. 2013;:e50103 pubmed publisher
    ..In the latter case, three T6SS-secreted proteins, namely Tse1, Tse2 and Tse3 have been identified as the toxins injected in the target bacteria (Figure 1)...
  8. Ma Q, He X. Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2. Pharmacol Rev. 2012;64:1055-81 pubmed publisher
    ..the nuclear factor erythroid 2-related factor 2 (Nrf2) and the Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1 (Keap1)...
  9. Seifert M, Przekopowitz M, Taudien S, Lollies A, Ronge V, Drees B, et al. Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions. Proc Natl Acad Sci U S A. 2015;112:E546-55 pubmed publisher
    ..was supported by reverse regulation of B-cell lymphoma 6 and PR domain containing 1 and differential BTB and CNC homology 1, basic leucine zipper transcription factor 2 expression...
  10. Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J. Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci. 2016;73:3221-47 pubmed publisher
    ..The vertebrate Nrf2 belongs to Cap 'n' Collar (Cnc) bZIP family of transcription factors and shares a high homology with SKN-1 from Caenorhabditis elegans or CncC ..
  11. Chinen J, Cowan M. Advances and highlights in primary immunodeficiencies in 2017. J Allergy Clin Immunol. 2018;142:1041-1051 pubmed publisher
    ..v-Rel avian reticuloendotheliosis viral oncogene homolog A (RELA), hypoxia upregulated 1 (HYOU1), BTB domain and CNC homolog 2 (BACH2), CD70, and CD55; (5) use of rapamycin and the phosphoinositide 3-kinase inhibitor leniolisib to ..
  12. Tseng I, Huang W, Jhuang Y, Chang Y, Hsu H, Jeng Y. Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma. J Pathol. 2017;242:134-139 pubmed publisher
    ..Two-thirds of patients with Carney complex harbour germline mutations in PRKAR1A, which encodes the type I regulatory subunit of protein kinase A (PKA)...
  13. Cui Y, Liu K, Liang Y, Ip M, Mak J. Inhibition of monoamine oxidase-B by selegiline reduces cigarette smoke-induced oxidative stress and inflammation in airway epithelial cells. Toxicol Lett. 2017;268:44-50 pubmed publisher
    ..the nuclear factor erythroid 2 related factor 2 (Nrf2) and cytosol translocation of its negative regulator, BTB and CNC homolog 1 (Bach1)...
  14. Ka S, Bang I, Bae E, Park B. Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor. FASEB J. 2017;31:3999-4010 pubmed publisher
    ..of KO mice, nuclear factor erythroid 2-related factor 2 (Nrf2) was down-regulated; conversely, BTB domain and CNC homolog 1 (Bach1), a nuclear repressor of Nrf2, were up-regulated...
  15. Tsuneyoshi T, Kunimura K, Morihara N. S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells. Nitric Oxide. 2019;84:22-29 pubmed publisher
    ..Additionally, NO-donors induced the degradation of BTB domain and CNC homolog 1 (BACH1), a transcriptional repressor that can compete with NRF2...
  16. Yamaoka M, Shimizu H, Takahashi T, Omori E, Morimatsu H. Dynamic changes in Bach1 expression in the kidney of rhabdomyolysis-associated acute kidney injury. PLoS ONE. 2017;12:e0180934 pubmed publisher
    ..BTB and CNC homology 1 (Bach1) is a heme-responsive transcription factor that represses HO-1...
  17. Zhang Y, Ou Y, Yu D, Yong X, Wang X, Zhu B, et al. Clinicopathological study of centrally necrotizing carcinoma of the breast. BMC Cancer. 2015;15:282 pubmed publisher
    Centrally necrotizing carcinoma of the breast (CNC) represents a newly-identified subset of breast cancer. The clinical and pathological characteristics of this breast cancer subtype are not yet completely understood...
  18. Hofland J, de Herder W, Derks L, Hofland L, van Koetsveld P, de Krijger R, et al. Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing's syndrome. Eur J Endocrinol. 2013;168:67-74 pubmed publisher
    ..Mutations in the cAMP protein kinase A regulatory subunit type 1A (PRKAR1A) are causative of PPNAD...
  19. Park E, Khaliullin T, Shurin M, Kisin E, Yanamala N, Fadeel B, et al. Fibrous nanocellulose, crystalline nanocellulose, carbon nanotubes, and crocidolite asbestos elicit disparate immune responses upon pharyngeal aspiration in mice. J Immunotoxicol. 2018;15:12-23 pubmed publisher
    ..This study investigated effects of four fibrous materials, i.e. nanofibrillar/nanocrystalline celluloses (NCF and CNC), single-walled carbon nanotubes (CNTs), and crocidolite asbestos (ASB), on pulmonary inflammation and immune ..
  20. Crocker M, Gourgari E, Lodish M, Stratakis C. Use of aromatase inhibitors in large cell calcifying sertoli cell tumors: effects on gynecomastia, growth velocity, and bone age. J Clin Endocrinol Metab. 2014;99:E2673-80 pubmed publisher
    ..Sertoli cell tumors (LCCSCT) present in isolation or, especially in children, in association with Carney Complex (CNC) or Peutz-Jeghers Syndrome (PJS)...
  21. Wang X, Liu J, Jiang L, Wei X, Niu C, Wang R, et al. Bach1 Induces Endothelial Cell Apoptosis and Cell-Cycle Arrest through ROS Generation. Oxid Med Cell Longev. 2016;2016:6234043 pubmed publisher
    The transcription factor BTB and CNC homology 1 (Bach1) regulates genes involved in the oxidative stress response and cell-cycle progression...
  22. Agrawal J, Ludwig B, Roy B, Dwivedi Y. Chronic Testosterone Increases Impulsivity and Influences the Transcriptional Activity of the Alpha-2A Adrenergic Receptor Signaling Pathway in Rat Brain. Mol Neurobiol. 2018;: pubmed publisher
    ..The transcript levels Adra2a and Gαs genes and PKA subunits encoded by Prkar1a, Prkar1b, Prkar2a, and Prkaca genes were significantly upregulated in PFC of testosterone treated rats...
  23. Wang T, Ding J, Zhang Y, Wang D, Liu W. Complex structure of type VI peptidoglycan muramidase effector and a cognate immunity protein. Acta Crystallogr D Biol Crystallogr. 2013;69:1889-900 pubmed publisher
    ..The T6SS of Pseudomonas aeruginosa transports two lytic enzymes, Tse1 and Tse3, to degrade cell-wall peptidoglycan in the periplasm of rival bacteria that are competing for niches via ..
  24. Karim S, Mirza Z, Chaudhary A, Abuzenadah A, Gari M, Al Qahtani M. Assessment of Radiation Induced Therapeutic Effect and Cytotoxicity in Cancer Patients Based on Transcriptomic Profiling. Int J Mol Sci. 2016;17:250 pubmed publisher
    ..A member 1 (MS4A1), immunoglobulin heavy constant mu (IGHM), chemokine (C-C motif) receptor 7 (CCR7), BTB and CNC homology 1 transcription factor 2 (BACH2), and B-cell CLL/lymphoma 11B (BCL11B)...
  25. Zhang Z, Leir S, Harris A. Oxidative stress regulates CFTR gene expression in human airway epithelial cells through a distal antioxidant response element. Am J Respir Cell Mol Biol. 2015;52:387-96 pubmed publisher
    ..Under normal conditions, the -44-kb ARE is occupied by the repressor BTB and CNC homology 1, basic leucine zipper transcription factor (Bach1), and v-Maf avian musculoaponeurotic fibrosarcoma ..
  26. Salpea P, Stratakis C. Carney complex and McCune Albright syndrome: an overview of clinical manifestations and human molecular genetics. Mol Cell Endocrinol. 2014;386:85-91 pubmed publisher
    ..Carney complex, which is caused largely by inactivating Protein kinase A, regulatory subunit, type I, Alpha (PRKAR1A) gene mutations...
  27. Ugolini M, Keil M, Paradiso E, Wu J, Stratakis C. Anxiety-like behavior and other consequences of early life stress in mice with increased protein kinase A activity. Behav Brain Res. 2018;348:22-30 pubmed publisher
    ..We recently reported that adult mice (Prkar1a+/-) with haploinsufficiency for the main regulatory subunit of the protein kinase A (PKA) exhibit an anxiety-like ..
  28. Best Rocha A, Patel K, Hicks J, Edmonds J, Paldino M, Wu H. Novel Association of Odontogenic Myxoma with Constitutional Chromosomal 1q21 Microduplication: Case Report and Review of the Literature. Pediatr Dev Pathol. 2016;19:139-45 pubmed publisher
    ..mutations in the GNAS gene have not been identified in OM to date, and only 2 of 17 OMs showed mutations in the PRKAR1A gene...
  29. Noda K, Kitami M, Kitami K, Kaku M, Komatsu Y. Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development. Proc Natl Acad Sci U S A. 2016;113:E2589-97 pubmed publisher
    ..Although osteogenic differentiation in cranial neural crest (CNC)-derived cells occurred normally in Ift20-mutant cells, the process of mineralization was severely attenuated due ..
  30. Zhang L, Zhang D, Zhao X, Sun W. Erythropoietin Rescues Primary Rat Cortical Neurons by Altering the Nrf2:Bach1 Ratio: Roles of Extracellular Signal-Regulated Kinase 1/2. Neurochem Res. 2017;: pubmed publisher
    ..Alteration of the nuclear factor erythroid 2-related factor (Nrf2)/BTB-to-CNC homology 1 (Bach1) ratio by Erk1/2 ameliorates the oxidative stress which occurs in human macrophages...
  31. Bourdeau I, Stratakis C. Cyclic AMP-dependent signaling aberrations in macronodular adrenal disease. Ann N Y Acad Sci. 2002;968:240-55 pubmed
    ..either isolated (rarely) or in the context of Carney complex, is caused (in most cases) by mutations of the PRKAR1A gene; and (ii) ACTH-independent macronodular adrenal hyperplasia (AIMAH), or massive macronodular adrenal disease ..
  32. Patronas Y, Horvath A, GREENE E, Tsang K, Bimpaki E, Haran M, et al. In vitro studies of novel PRKAR1A mutants that extend the predicted RI? protein sequence into the 3'-untranslated open reading frame: proteasomal degradation leads to RI? haploinsufficiency and Carney complex. J Clin Endocrinol Metab. 2012;97:E496-502 pubmed publisher
    Carney complex (CNC) is a multiple endocrine neoplasia syndrome due to inactivating mutations in the PRKAR1A gene that codes for type I? regulatory (RI?) subunit of protein kinase A...
  33. Simons Morton B, Klauer S, Ouimet M, Guo F, Albert P, Lee S, et al. Naturalistic teenage driving study: Findings and lessons learned. J Safety Res. 2015;54:41-4 pubmed publisher
    ..Overall teenage crash and near-crash (CNC) rates declined over time, but were >4 times higher among teenagers than adults...
  34. Kim H, Han J, Chan J. Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation. Gene. 2016;584:17-25 pubmed publisher
    Nrf1 (also referred to as NFE2L1) is a member of the CNC-bZIP family of transcription factors that are characterized by a highly conserved CNC-domain, and a basic-leucine zipper domain required for dimerization and DNA binding...
  35. Pomatto L, Wong S, Carney C, Shen B, Tower J, Davies K. The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster. Aging (Albany NY). 2017;9:1153-1185 pubmed publisher
    ..Loss of adaptive homeostasis, increases accumulation of DNA, protein, and lipid damage. During acute stress, the Cnc-C (Drosophila Nrf2 orthologue) transcriptionally-regulated 20S proteasome degrades damaged proteins in an ..
  36. Cui Q, Fu J, Hu Y, Li Y, Yang B, Li L, et al. Deficiency of long isoforms of Nfe2l1 sensitizes MIN6 pancreatic ? cells to arsenite-induced cytotoxicity. Toxicol Appl Pharmacol. 2017;329:67-74 pubmed publisher
    ..Like nuclear factor erythroid 2 like 2 (NFE2L2), NFE2L1 also belongs to the cap 'n' collar (CNC) basic-region leucine zipper (bZIP) transcription factor family, and regulates antioxidant response element (ARE) ..
  37. Grönholm M, Vossebein L, Carlson C, Kuja Panula J, Teesalu T, Alfthan K, et al. Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A. J Biol Chem. 2003;278:41167-72 pubmed
    ..These results identify merlin as the first neuronal binding partner for PKA-RIbeta and suggest a novel function for merlin in connecting neuronal cytoskeleton to PKA signaling. ..
  38. Villares A, Moreau C, Dammak A, Capron I, Cathala B. Kinetic aspects of the adsorption of xyloglucan onto cellulose nanocrystals. Soft Matter. 2015;11:6472-81 pubmed publisher
    In this work, the adsorption of a neutral flexible polysaccharide, xyloglucan (XG), onto thin cellulose nanocrystal (CNC) surfaces has been investigated to get more insight into the CNC-XG association...
  39. Mohamed M, W Salleh W, Jaafar J, Ismail A, Abd Mutalib M, Mohamad A, et al. Physicochemical characterization of cellulose nanocrystal and nanoporous self-assembled CNC membrane derived from Ceiba pentandra. Carbohydr Polym. 2017;157:1892-1902 pubmed publisher
    ..utilisation of the kapok fibre (Ceiba pentandra) as a raw material for the fabrication of cellulose nanocrystal (CNC) and self-assembled CNC membranes...
  40. Gu J, Hu C, Zhong R, Tu D, Yun H, Zhang W, et al. Isolation of cellulose nanocrystals from medium density fiberboards. Carbohydr Polym. 2017;167:70-78 pubmed publisher
    ..5% yield, similar to 27.4% of CNC yield from eucalyptus with UF resin, but less than 31.2% yield from eucalyptus...
  41. Calebiro D, Hannawacker A, Lyga S, Bathon K, Zabel U, Ronchi C, et al. PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit. Nat Commun. 2014;5:5680 pubmed publisher
    ..We conclude that the two mutations cause high basal catalytic activity and lack of regulation by cAMP through interference of complex formation between the regulatory and the catalytic subunits of PKA. ..
  42. Novak S, Lin P, Li C, Borodinov N, Han Z, Monmeyran C, et al. Electrospray Deposition of Uniform Thickness Ge23Sb7S70 and As40S60 Chalcogenide Glass Films. J Vis Exp. 2016;: pubmed publisher
    ..In this approach, uniform thickness films are fabricated through the use of computer numerical controlled (CNC) motion. Chalcogenide glass (ChG) is written over the substrate by a single nozzle along a serpentine path...
  43. Fisher H, Jacobs Palmer E, Lassance J, Hoekstra H. The genetic basis and fitness consequences of sperm midpiece size in deer mice. Nat Commun. 2016;7:13652 pubmed publisher
    ..Using forward genetics, we identify a gene associated with midpiece length: Prkar1a, which encodes the R1α regulatory subunit of PKA...
  44. Du L, Wang J, Zhang Y, Qi C, Wolcott M, Yu Z. Preparation and Characterization of Cellulose Nanocrystals from the Bio-ethanol Residuals. Nanomaterials (Basel). 2017;7: pubmed publisher
    ..Compared with CNCs from microfibrillated cellulose (CNCMCC), HRMMW and its resulted CNC present the smallest particle size and aspect ratio...
  45. Du P, Zhao H, Cao H, Huang C, Liu W, Li Y. Transformation of halobenzoquinones with the presence of amino acids in water: Products, pathways and toxicity. Water Res. 2017;122:299-307 pubmed publisher
    ..can easily covalently incorporate into HBQs via nucleophilic addition (CBQ and DCBQ) or substitution (TCBQ) through CNC or CSC linkages...
  46. Zhu G, Liu F, Ouyang S, Zhou R, Jiang F, Zhang B, et al. BACH1 promotes the progression of human colorectal cancer through BACH1/CXCR4 pathway. Biochem Biophys Res Commun. 2018;499:120-127 pubmed publisher was to investigate clinical significance, biological functions and underlying mechanisms of BTB Domain and CNC Homolog 1(BACH1) deregulation in human colorectal cancer (CRC)...
  47. Burton K, McDermott D, Wilkes D, Poulsen M, Nolan M, Goldstein M, et al. Haploinsufficiency at the protein kinase A RI alpha gene locus leads to fertility defects in male mice and men. Mol Endocrinol. 2006;20:2504-13 pubmed
    ..We report here that male mice heterozygous for the Prkar1a gene have severely reduced fertility...
  48. Forero D, Herteleer L, De Zutter S, Norrback K, Nilsson L, Adolfsson R, et al. A network of synaptic genes associated with schizophrenia and bipolar disorder. Schizophr Res. 2016;172:68-74 pubmed publisher
    ..functional pathway that could be novel candidates for BP and SZ: CREB1, CREM, GRIN2C, NPY2R, NF1, PPP3CB and PRKAR1A. These 7 genes were analyzed in a HapMap based association study comprising 48 common SNPs in 486 SZ, 351 BP ..
  49. Lim L, Rosli N, Ahmad I, Mat Lazim A, Mohd Amin M. Synthesis and Swelling Behavior of pH-Sensitive Semi-IPN Superabsorbent Hydrogels Based on Poly(acrylic acid) Reinforced with Cellulose Nanocrystals. Nanomaterials (Basel). 2017;7: pubmed publisher
    pH-sensitive poly(acrylic acid) (PAA) hydrogel reinforced with cellulose nanocrystals (CNC) was prepared...
  50. Alizadehgiashi M, Khabibullin A, Li Y, Prince E, Abolhasani M, Kumacheva E. Studies of Shear-induced Alignment of Anisotropic Nanoparticles in a Single-Droplet Oscillatory Microfluidic Platform. Langmuir. 2017;: pubmed publisher
    ..cellulose nanocrystals (CNCs), we explore the effect of the shear rate and suspension viscosity on the flow-induced CNC alignment and subsequent relaxation to the isotropic state...
  51. Beuguel Q, Tavares J, Carreau P, Heuzey M. Ultrasonication of spray- and freeze-dried cellulose nanocrystals in water. J Colloid Interface Sci. 2018;516:23-33 pubmed publisher
    ..Since the same maximum dispersion state was reached for both CNC types, it indicated that the spray drying process did not limit dispersion, provided that sufficient ..
  52. Jones K, Shapero M, Chevrette M, Fournier R. Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A. Cell. 1991;66:861-72 pubmed
    Tissue-specific extinguisher 1 (TSE1) is a trans-acting locus on human chromosome 17 that down-regulates expression of seven liver genes in hepatoma x fibroblast hybrids...
  53. Yazdan P, Haghighat Z, Guitart J, Gerami P. Epithelioid and fusiform blue nevus of chronically sun-damaged skin, an entity distinct from the epithelioid blue nevus of the Carney complex. Am J Surg Pathol. 2013;37:81-8 pubmed publisher
    ..Over 50% of patients with CNC harbor mutations in the gene PRKAR1A, which codes for protein kinase A regulatory subunit 1? (R1?) involved in the signaling pathway regulating ..
  54. Guo H, Xu J, Xiong H, Hu S. Case studies of two related Chinese patients with Carney complex presenting with extensive cardiac myxomas and PRKAR1A gene mutation of c.491_492delTG. World J Surg Oncol. 2015;13:83 pubmed publisher
    ..Carney complex is most commonly caused by mutations in the PRKAR1A gene on chromosome 17q22-24...
  55. Elli F, Bordogna P, de Sanctis L, Giachero F, Verrua E, Segni M, et al. Screening of PRKAR1A and PDE4D in a Large Italian Series of Patients Clinically Diagnosed With Albright Hereditary Osteodystrophy and/or Pseudohypoparathyroidism. J Bone Miner Res. 2016;31:1215-24 pubmed publisher
    ..Moreover, mutations in PRKAR1A and PDE4D genes have been recently detected in patients with acrodysostosis (ACRDYS), showing a skeletal and ..
  56. Su C, Liu Z, Wang Y, Wang Y, Song E, Song Y. The electrophilic character of quinones is essential for the suppression of Bach1. Toxicology. 2017;387:17-26 pubmed publisher
    ..BTB and CNC homology-1 (Bach1), like Kelch-like ECH-associated protein 1 (Keap1), is one of a negative regulator of Nrf2 that ..
  57. Fortenberry R, Lee T, Huang X. Towards completing the cyclopropenylidene cycle: rovibrational analysis of cyclic N3+, CNN, HCNN+, and CNC. Phys Chem Chem Phys. 2017;19:22860-22869 pubmed publisher
    ..whether its isoelectronic, cyclic, fellow aromatics of c-N3+, c-CNN, HCNN+, and c-CNC- are as well...
  58. Horvath A, Bossis I, Giatzakis C, Levine E, Weinberg F, Meoli E, et al. Large deletions of the PRKAR1A gene in Carney complex. Clin Cancer Res. 2008;14:388-95 pubmed publisher
    Since the identification of PRKAR1A mutations in Carney complex, substitutions and small insertions/deletions have been found in approximately 70% of the patients...
  59. Zhang X, Zhang Y. Reinforcement effect of poly(butylene succinate) (PBS)-grafted cellulose nanocrystal on toughened PBS/polylactic acid blends. Carbohydr Polym. 2016;140:374-82 pubmed publisher
    ..acid (PLA) blends modified with dicumyl peroxide (DCP) were reinforced by PBS-g-cellulose nanocrystal (CNC) through melt mixing...
  60. Davudian S, Shajari N, Kazemi T, Mansoori B, Salehi S, Mohammadi A, et al. BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes. Biomed Pharmacother. 2016;84:191-198 pubmed publisher
    Metastasis to distant organs is a hallmark of many tumor cells. BACH1 (BTB and CNC homology 1) is a transcriptional factor which promotes the migration and invasion of breast cancer cells...
  61. An X, Long Y, Ni Y. Cellulose nanocrystal/hexadecyltrimethylammonium bromide/silver nanoparticle composite as a catalyst for reduction of 4-nitrophenol. Carbohydr Polym. 2017;156:253-258 pubmed publisher
    ..In this paper, hexadecyl-trimethylammonium bromide (CTAB) surfactant-adsorbed cellulose nanocrystals (CNC) was employed as a support for silver nanoparticles (Ag NPs)...
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    ..FD)-like lesions (FDLL) in mice, as well as isolated myxomas in humans may be caused by inactivation of PRKAR1A, the gene coding for the type 1a regulatory subunit (R1?) of cAMP-dependent protein kinase (PKA)...
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    In this study, for the first time, the edible pectin film was reinforced by crystalline nanocelullose (CNC)...
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    ..The T allele of rs60684937 was associated with a relatively increased expression of a non-coding transcript of PRKAR1A (cAMP-dependent protein kinase type I-alpha regulatory subunit) in 58 SCD patients (P?=?7...
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    ..present work, the utilization of red algae waste as raw material to produce high-quality cellulose nanocrystals (CNC) has been investigated, and the ability of the as-isolated CNC to reinforce polymer has been studied...
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    ..Both the Tat-induced increase in intracellular cAMP and IL-6 mRNA levels in CNS-ECs may play a role in altering the blood-brain barrier and thereby inducing pathology often observed in AIDS dementia. ..
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