Gene Symbol: PRKACG
Description: protein kinase cAMP-activated catalytic subunit gamma
Alias: BDPLT19, KAPG, PKACg, cAMP-dependent protein kinase catalytic subunit gamma, PKA C-gamma, protein kinase, cAMP-dependent, catalytic, gamma, protein kinase, cAMP-dependent, gamma catalytic subunit, serine(threonine) protein kinase
Species: human
Products:     PRKACG

Top Publications

  1. Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J. 2003;22:1313-24 pubmed
    ..This effect represents, together with phosphorylation of nucleosome components such as histone H3, an essential step leading to selective transcriptional activation of NF-kappaB-dependent gene expression. ..
  2. Jacometo C, Zhou Z, Luchini D, Trevisi E, Corrêa M, Loor J. Maternal rumen-protected methionine supplementation and its effect on blood and liver biomarkers of energy metabolism, inflammation, and oxidative stress in neonatal Holstein calves. J Dairy Sci. 2016;99:6753-6763 pubmed publisher
  3. Zhang H, Chen R, Sun G, Yang L, Zhu Y, Xu X, et al. Protective effects of total flavonoids from Clinopodium chinense (Benth.) O. Ktze on myocardial injury in vivo and in vitro via regulation of Akt/Nrf2/HO-1 pathway. Phytomedicine. 2018;40:88-97 pubmed publisher
    ..TFCC protects against myocardial injury and enhances cellular antioxidant defense capacity by inducing the phosphorylation of AKT, which subsequently activated the Nrf2/HO-1 signaling pathway. ..
  4. Lee T, Bai K, Chen Y, Lee T, Chung C, Tsai W, et al. Histone deacetylase inhibition of cardiac autophagy in rats on a high?fat diet with low?dose streptozotocin-induced type 2 diabetes mellitus. Mol Med Rep. 2017;: pubmed publisher
    ..The present study demonstrated that MPT0E014 may improve cardiac function in T2DM rats by modulating myocardial autophagy, inflammation and insulin signaling...
  5. Oishi K, Yamamoto S, Itoh N, Nakao R, Yasumoto Y, Tanaka K, et al. Wheat alkylresorcinols suppress high-fat, high-sucrose diet-induced obesity and glucose intolerance by increasing insulin sensitivity and cholesterol excretion in male mice. J Nutr. 2015;145:199-206 pubmed publisher
  6. Wang Z, Li R, Zhong R. Extracellular matrix promotes proliferation, migration and adhesion of airway smooth muscle cells in a rat model of chronic obstructive pulmonary disease via upregulation of the PI3K/AKT signaling pathway. Mol Med Rep. 2018;18:3143-3152 pubmed publisher
    ..In conclusion, ECM proteins promoted proliferation, migration and adhesion of ASMCs form rat models of COPD through activation of the PI3K/AKT signaling pathway. ..
  7. Koronowicz A, Drozdowska M, Banks P, Piasna Słupecka E, Domagała D, Leszczyńska T. Fatty Acids of CLA-enriched Egg Yolks Can Induce Mitochondrial Pathway of Apoptosis in MCF-7 Breast Cancer Cells. Anticancer Res. 2018;38:2861-2870 pubmed
    ..Taken together, our results suggest that activation of the mitochondrial apoptotic pathway may be a potential mechanism of EFA-CLA action. ..
  8. Berner D, Zenkel M, Pasutto F, Hoja U, Liravi P, Gusek Schneider G, et al. Posttranscriptional Regulation of LOXL1 Expression Via Alternative Splicing and Nonsense-Mediated mRNA Decay as an Adaptive Stress Response. Invest Ophthalmol Vis Sci. 2017;58:5930-5940 pubmed publisher
  9. Liu Y, Yu Q, Chen Y. Effect of silibinin on CFLAR-JNK pathway in oleic acid-treated HepG2 cells. Biomed Pharmacother. 2018;108:716-723 pubmed publisher

More Information

Publications149 found, 100 shown here

  1. Shi T, Sun J, Wu X, Weng J, Wang P, Qie H, et al. Transcriptome analysis of Chinese bayberry (Myrica rubra Sieb. et Zucc.) fruit treated with heat and 1-MCP. Plant Physiol Biochem. 2018;133:40-49 pubmed publisher
    ..These results might improve our understanding of the mechanisms of heat and 1-MCP inhibition of fruit postharvest physiology and prolongation of fruit shelf life. ..
  2. Singh S, Tao S, Fields T, Webb S, Harris R, Rao R. Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice. Dis Model Mech. 2015;8:931-40 pubmed publisher
  3. Suliman H, Kraft B, Bartz R, Chen L, Welty Wolf K, Piantadosi C. Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2017;313:L699-L709 pubmed publisher
    ..These findings imply that mitochondrial QC activation in pneumonia-damaged AT2 cells promotes cell survival in support of alveolar function. ..
  4. Yang B, Lan S, Dieudé M, Sabo Vatasescu J, Karakeussian Rimbaud A, Turgeon J, et al. Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2018;29:1900-1916 pubmed publisher
    ..These findings also demonstrate the predominant role of microvascular over tubular injury as a driver of progressive renal damage and fibrosis after IRI. ..
  5. Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, et al. Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis. Int J Oncol. 2018;52:1165-1177 pubmed publisher
    ..Therefore, the enhanced cytotoxic effect of GEF under AAS culture conditions is thought to be mediated by atypical necroptosis. ..
  6. Cheng H, Xia B, Su C, Chen K, Chen X, Chen P, et al. PI3K/Akt signaling pathway and Hsp70 activate in hippocampus of rats with chronic manganese sulfate exposure. J Trace Elem Med Biol. 2018;50:332-338 pubmed publisher
    ..05). Chronic MnSO4 exposure can result in apoptosis of central nerve cells, activate the PI3K/Akt signaling pathway in rats' hippocampus, and upregulate Hsp70 transcription and translation. ..
  7. Pagel R, Bär F, Schröder T, Sünderhauf A, Künstner A, Ibrahim S, et al. Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine. FASEB J. 2017;31:4707-4719 pubmed publisher
    ..König, P., Tsang, A. H., Bettenworth, D., Divanovic, S., Lehnert, H., Fellermann, K., Oster, H., Derer, S., Sina, C. Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine. ..
  8. Zhao L, Wang L, Di S, Xu Q, Ren Q, Chen S, et al. Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits anti-inflammatory activity in lipopolysaccharide/interferon γ-activated murine macrophages and animal models of inflammation. Biomed Pharmacother. 2018;105:606-615 pubmed publisher
  9. Beke L, Kig C, Linders J, Boens S, Boeckx A, Van Heerde E, et al. MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. Biosci Rep. 2015;35: pubmed publisher
    ..Thus, targeting MELK by the inhibition of both its catalytic activity and its protein stability might sensitize tumours to DNA-damaging agents or radiation therapy by lowering the DNA-damage threshold. ..
  10. Cansby E, Magnusson E, Nuñez Durán E, Amrutkar M, Pedrelli M, Parini P, et al. STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2018;: pubmed publisher
  11. Rotllant G, Nguyen T, Sbragaglia V, Rahi L, Dudley K, Hurwood D, et al. Sex and tissue specific gene expression patterns identified following de novo transcriptomic analysis of the Norway lobster, Nephrops norvegicus. BMC Genomics. 2017;18:622 pubmed publisher
    ..The N. norvegicus data provide a foundation for future gene-based reproductive studies. ..
  12. Chen H, Wang Q, Yin Y, Li S, Niu D, Wang H. Genotypic variations between wild-type and small colony variant of Staphylococcus aureus in prosthetic valve infectious endocarditis: a comparative genomic and transcriptomic analysis. Int J Antimicrob Agents. 2018;51:655-658 pubmed publisher
    ..aureus. In conclusion, the reduced growth rate and decreased virulence of MRSA SCV strains may be related to mutations in and downregulation of genes associated with metabolism and virulence, especially plsY, deoC, eap and sstD. ..
  13. Kuo J, Shih T, Lin J, Lai K, Lin M, Yang M, et al. Cantharidin induces DNA damage and inhibits DNA repair-associated protein expressions in TSGH8301 human bladder cancer cell. Anticancer Res. 2015;35:795-804 pubmed
    ..In conclusion, we found that cantharidin-induced cell death may occur through the induction of DNA damage and suppression of DNA repair-associated protein expression in TSGH8301 cells. ..
  14. Tse A, Li J, Chan T, Wu R, Lai K. Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma. Aquat Toxicol. 2015;165:189-96 pubmed publisher
    ..This study provides new insights on how hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells in fish, which is fundamentally important in environmental sciences and reproductive biology. ..
  15. Kong X, Kuilman T, Shahrabi A, Boshuizen J, Kemper K, Song J, et al. Cancer drug addiction is relayed by an ERK2-dependent phenotype switch. Nature. 2017;550:270-274 pubmed publisher
    ..Our results uncover a pathway that underpins drug addiction in cancer cells, which may help to guide the use of alternating therapeutic strategies for enhanced clinical responses in drug-resistant cancers...
  16. Zhao J, Liu N, Hao X, Que L, Liu J, Tang X. Association between integrin-linked kinase and hyperthermia in oral squamous cell carcinoma. Oncol Lett. 2017;14:7705-7714 pubmed publisher
    ..Therefore, ILK silencing combined with hypothermia may serve as a novel combination therapy strategy against OSCC...
  17. Rotllan N, Chamorro Jorganes A, Araldi E, Wanschel A, Aryal B, Aranda J, et al. Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis. FASEB J. 2015;29:597-610 pubmed publisher
    ..Together, these results provide evidence that macrophage Akt2 regulates migration, the inflammatory response and cholesterol metabolism and suggest that targeting Akt2 in macrophages might be beneficial for treating atherosclerosis. ..
  18. Lemstrová R, Brynychová V, Hughes D, Hlaváč V, Dvorak P, Doherty J, et al. Dysregulation of KRAS signaling in pancreatic cancer is not associated with KRAS mutations and outcome. Oncol Lett. 2017;14:5980-5988 pubmed publisher
    ..This may partly explain the failure of KRAS-targeted therapies in PDAC...
  19. Liu L, Lin Y, Liu L, Bian Y, Zhang L, Gao X, et al. 14-3-3γ Regulates Lipopolysaccharide-Induced Inflammatory Responses and Lactation in Dairy Cow Mammary Epithelial Cells by Inhibiting NF-κB and MAPKs and Up-Regulating mTOR Signaling. Int J Mol Sci. 2015;16:16622-41 pubmed publisher
  20. Yu C, Pan S, Dong M, Niu Y. Astragaloside IV attenuates lead acetate-induced inhibition of neurite outgrowth through activation of Akt-dependent Nrf2 pathway in vitro. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1195-1203 pubmed publisher
  21. Rubenstein M, Hollowell C, Guinan P. Suppression of BCL2 by Antisense Oligonucleotides and Compensation by Non-Targeted Genes May Enhance Tumor Proliferation. In Vivo. 2015;29:687-93 pubmed
    ..This could be accomplished by dual monospecific targeting KI-67 and BCL2, or with a bispecific (or proposed multispecific) oligonucleotide simultaneously targeting both. ..
  22. Sawicki M, Rondeau M, Courteaux B, Rabenoelina F, Guerriero G, Gomès E, et al. On a Cold Night: Transcriptomics of Grapevine Flower Unveils Signal Transduction and Impacted Metabolism. Int J Mol Sci. 2019;20: pubmed publisher
    ..From a long-term perspective, our study provides useful starting points for future investigation. ..
  23. Liu S, Vallejo R, Gao G, Palti Y, Weber G, Hernandez A, et al. Identification of single-nucleotide polymorphism markers associated with cortisol response to crowding in rainbow trout. Mar Biotechnol (NY). 2015;17:328-37 pubmed publisher
    ..However, the reference genome resources currently available for rainbow trout require continued improvement as demonstrated by the unmapped SNPs and the putative assembly errors detected in this study. ..
  24. Han H, Xue P, Dong H, Zhu S, Zhao Q, Huang B. Screening and characterization of apical membrane antigen 1 interacting proteins in Eimeria tenella. Exp Parasitol. 2016;170:116-124 pubmed publisher
    ..The data suggested that EtAMA1 may be important during host cell invasion, but also involved in other biological processes. ..
  25. Gong J, Wang X, Wang T, Chen J, Xie X, Hu H, et al. Molecular signal networks and regulating mechanisms of the unfolded protein response. J Zhejiang Univ Sci B. 2017;18:1-14 pubmed publisher
  26. Katsube A, Hayashi H, Kusuhara H. Pim-1L Protects Cell Surface-Resident ABCA1 From Lysosomal Degradation in Hepatocytes and Thereby Regulates Plasma High-Density Lipoprotein Level. Arterioscler Thromb Vasc Biol. 2016;36:2304-2314 pubmed
    ..Our findings may aid the development of high-density lipoprotein-targeted therapy. ..
  27. Xing P, Liao Z, Ren Z, Zhao J, Song F, Wang G, et al. Roles of low-density lipoprotein receptor-related protein 1 in tumors. Chin J Cancer. 2016;35:6 pubmed publisher
    ..Only by understanding the mechanisms of these effects can we develop novel diagnostic and therapeutic strategies for cancers mediated by LRP1. ..
  28. Barcellos Hoff M, Cucinotta F. New tricks for an old fox: impact of TGFβ on the DNA damage response and genomic stability. Sci Signal. 2014;7:re5 pubmed publisher
  29. Amrutkar M, Cansby E, Chursa U, Nuñez Durán E, Chanclón B, Ståhlman M, et al. Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model. Diabetes. 2015;64:2791-804 pubmed publisher
    ..The findings suggest that STK25 deficiency protects against the metabolic consequences of chronic exposure to dietary lipids and highlight the potential of STK25 antagonists for the treatment of type 2 diabetes. ..
  30. Zhao C, Ma X, Guo H, Li P, Liu H. RIP2 deficiency attenuates cardiac hypertrophy, inflammation and fibrosis in pressure overload induced mice. Biochem Biophys Res Commun. 2017;493:1151-1158 pubmed publisher
    ..Taken together, our data indicated that RIP2-deficience ameliorated cardiac hypertrophy, inflammation and fibrosis through modulating multiple signaling pathways. ..
  31. Huang Y, Zhu Z, Xie M, Xue J. Involvement of adenosine monophosphate-activated protein kinase in the influence of timed high-fat evening diet on the hepatic clock and lipogenic gene expression in mice. Nutr Res. 2015;35:792-9 pubmed publisher
  32. Fu G, Liu S, Nan X, Dale O, Zhao Z, Chen Y, et al. Quantitative Structure-Activity Relationship Analysis and a Combined Ligand-Based/Structure-Based Virtual Screening Study for Glycogen Synthase Kinase-3. Mol Inform. 2014;33:627-40 pubmed publisher
  33. Szobi A, Rajtik T, ADAMEOVA A. Effects of necrostatin-1, an inhibitor of necroptosis, and its inactive analogue Nec-1i on basal cardiovascular function. Physiol Res. 2016;65:861-865 pubmed
    ..These effects of Nec-1 are likely due to its off-target action or RIP1 has an important role in the regulation of cardiovascular function independently of its action on the necroptotic pathway. ..
  34. Nuñez Durán E, Chanclón B, Sütt S, Real J, Marschall H, Wernstedt Asterholm I, et al. Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice. J Endocrinol. 2017;234:15-27 pubmed publisher
    ..Our findings highlight STK25 as a potential drug target for metabolic disease. ..
  35. Dai J, Liu T, Wang K, Pang Y, Wang Q, Chen Z. [Effects of Atorvastatin on Proliferation and Apoptosis of Leukemia Cell Line HL-60 and Its Mechanism of Signal Pathway]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:403-407 pubmed publisher
    ..62±2.41) respectively, significantly different from the negative control (t=4.806,3.800,4.313, P<0.05). Atorvastatin may inhibit the proliferation of HL-60 cells and induce apoptosis by inhibiting the PI3K/ATK/mTOR signaling pathway. ..
  36. Zeng X, Li Y, Ling H, Chen J, Guo S. Revealing proteins associated with symbiotic germination of Gastrodia elata by proteomic analysis. Bot Stud. 2018;59:8 pubmed publisher
    ..elata. The present study indicated the metabolic change and defensive reaction could disrupt the balance between Mycena and G. elata during mycorrhizal symbiotic germination. ..
  37. Huang C, Zhang Y, Wang J, Jiang J, Bao J. MCP-1 impacts RCT by repressing ABCA1, ABCG1, and SR-BI through PI3K/Akt posttranslational regulation in HepG2 cells. J Lipid Res. 2013;54:1231-40 pubmed publisher
    ..Our data suggest that MCP-1 impairs RCT activity in HepG2 cells by a PI3K/Akt-mediated posttranslational regulation of ABCA1, ABCG1, and SR-BI cell-surface expression...
  38. Li J, Wang R, Gannon O, Rezey A, Jiang S, Gerlach B, et al. Polo-like Kinase 1 Regulates Vimentin Phosphorylation at Ser-56 and Contraction in Smooth Muscle. J Biol Chem. 2016;291:23693-23703 pubmed
    ..Plk1 activation is regulated by SLK during contractile activation. Plk1 contributes to the pathogenesis of asthma. ..
  39. Li K, Gao P, Xiang P, Zhang X, Cui X, Ma L. Molecular mechanisms of PFOA-induced toxicity in animals and humans: Implications for health risks. Environ Int. 2017;99:43-54 pubmed publisher
    ..Both in vivo and in vitro studies are needed to better understand the PFOA-induced toxicity mechanisms as well as the associated health risk in humans. ..
  40. Saiyin H, Na N, Han X, Fang Y, Wu Y, Lou W, et al. BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity. Oncotarget. 2017;8:44669-44681 pubmed publisher
    ..This finding indicates that the intrinsic molecular merit that BRSK2 provides is a survival advantage to PDAC cells and strengthens the invasiveness of these neoplastic cells in energy-deprived environments. ..
  41. Cheng Y, Zhu Y, Xu J, Yang M, Chen P, Xu W, et al. PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway. Mol Cancer. 2018;17:13 pubmed publisher
    ..The expression of PKN2 in colon cancer cells suppresses tumor associated M2 macrophage polarization and tumor growth. Targeting PKN2 signaling pathway may provide a potential therapeutic strategy for colon cancer. ..
  42. Lee S, Han B, Cho J, Choi J, Lee J, Song H, et al. Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode. PLoS ONE. 2013;8:e70358 pubmed publisher
    ..The binding mode analysis suggests that the SKI-O-068 inhibitor can be improved by introducing functional groups that facilitate direct interaction with Lys67, which aid in the design of an optimized inhibitor. ..
  43. Kovarikova V, Burkuš J, Rehák P, Brzakova A, Solc P, Baran V. Aurora kinase A is essential for correct chromosome segregation in mouse zygote. Zygote. 2016;24:326-37 pubmed publisher
    ..In conclusion these data suggest that AURKA is essential for the correct chromosome segregation in the first mitosis as a prerequisite for normal later development after first cleavage. ..
  44. Jiang S, Tang D. Plk1 regulates MEK1/2 and proliferation in airway smooth muscle cells. Respir Res. 2015;16:93 pubmed publisher
    ..Together, these findings suggest that Plk1 is activated upon growth factor stimulation, which may control the activation of MEK1/2 and ERK1/2, and smooth muscle cell proliferation. ..
    ..It was found 100 ?M genistein provoked the increase of the frequency of agrobacterial transformation of tobacco leaf disks on 12%. ..
  46. Zhu X, Pan Q, Huang N, Wu J, Zhen N, Sun F, et al. RAD51 regulates CHK1 stability via autophagy to promote cell growth in esophageal squamous carcinoma cells. Tumour Biol. 2016;: pubmed
    ..Moreover, our data firstly shed insights into the possible application of autophagy inhibitors in treating RAD51 overexpressed EC patients. ..
  47. Li Y, Sun S, Zhong C, Wang X, Wu X, Zhu Z. Genetic mapping and development of co-segregating markers of RpsQ, which provides resistance to Phytophthora sojae in soybean. Theor Appl Genet. 2017;130:1223-1233 pubmed publisher
    ..sojae. ..
  48. Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield D. mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Free Radic Biol Med. 2018;114:94-101 pubmed publisher
    ..Oxidative stress, associated with chr21-related Aβ and mitochondrial alterations, may significantly contribute to this linkage of mTOR to AD-like neuropathology in DS. ..
  49. Liu Z, Chen T, Han Q, Chen M, You J, Fang F, et al. HDAC inhibitor LMK?235 promotes the odontoblast differentiation of dental pulp cells. Mol Med Rep. 2017;: pubmed publisher
    ..These findings indicated that LMK?235 may serve a key role in the proliferation and odontoblast differentiation of DPCs, and could be used to accelerate dental tissue regeneration...
  50. Burns E, Keith B, Refai M, Bothner B, Dyer W. Constitutive redox and phosphoproteome changes in multiple herbicide resistant Avena fatua L. are similar to those of systemic acquired resistance and systemic acquired acclimation. J Plant Physiol. 2018;220:105-114 pubmed publisher
  51. Gwee S, Radford R, Chow S, Syal M, Morsch M, Formella I, et al. Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish. Cell Mol Life Sci. 2018;75:4269-4285 pubmed publisher
    ..Collectively, these results suggest a hitherto unreported role of AurkB in regulating neuronal development and axonal outgrowth. ..
  52. Taylor S, Buechler J, Yonemoto W. cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Annu Rev Biochem. 1990;59:971-1005 pubmed
  53. Kuo Y, Huang H, Cai T, Wang T. Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila. Sci Rep. 2015;5:10339 pubmed publisher
    ..Furthermore, loss of TORC2 disrupted the nuclear localization of Myc, and inhibited Myc-dependent transcription. Together, our results reveal a Myc-dependent pathway by which TORC2 regulates cell growth. ..
  54. Hao P, Lu C, Ma Y, Xu L, Zhu J, Yu X. Roles of NlAKTIP in the Growth and Eclosion of the Rice Brown Planthopper, Nilaparvata lugens Stål, as Revealed by RNA Interference. Int J Mol Sci. 2015;16:22888-903 pubmed publisher
    ..This study provided a valuable clue of a potential target NlAKTIP for inhibiting the BPH, and also provided a new point of view on the interaction between BPH and resistant rice. ..
  55. Blesneac I, Chemin J, Bidaud I, Huc Brandt S, Vandermoere F, Lory P. Phosphorylation of the Cav3.2 T-type calcium channel directly regulates its gating properties. Proc Natl Acad Sci U S A. 2015;112:13705-10 pubmed publisher
    ..Our data show that Cav3.2 channels are highly phosphorylated in the mammalian brain and establish phosphorylation as an important mechanism involved in the dynamic regulation of Cav3.2 channel gating properties. ..
  56. Gadducci A, Biglia N, Tana R, Cosio S, Gallo M. Metformin use and gynecological cancers: A novel treatment option emerging from drug repositioning. Crit Rev Oncol Hematol. 2016;105:73-83 pubmed publisher
    ..Therefore long-term phase II-III clinical trials are strongly warranted to further investigate metformin activity in gynecological cancers. ..
  57. Mian E, Wiesmuller L. Phenotypic Analysis of ATM Protein Kinase in DNA Double-Strand Break Formation and Repair. Methods Mol Biol. 2017;1599:317-334 pubmed publisher
    ..This chapter summarizes these methods for functional characterization of ATM in patient LCLs and human cell lines. ..
  58. Prakasam G, Singh R, Iqbal M, Saini S, Tiku A, Bamezai R. Pyruvate kinase M knockdown-induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival. J Biol Chem. 2017;292:15561-15576 pubmed publisher
    ..On the basis of our observations, we propose an alternative therapeutic strategy of silencing either of the PKM isoforms along with AMPK in tumors. ..
  59. Stockton S, Gomes I, Liu T, Moraje C, Hipólito L, Jones M, et al. Morphine Regulated Synaptic Networks Revealed by Integrated Proteomics and Network Analysis. Mol Cell Proteomics. 2015;14:2564-76 pubmed publisher
    ..Together, these findings suggest a role for protein degradation and for the ubiquitin/proteasomal system in the etiology of opiate dependence and addiction. ..
  60. Reyland M, Jones D. Multifunctional roles of PKC?: Opportunities for targeted therapy in human disease. Pharmacol Ther. 2016;165:1-13 pubmed publisher
    ..This review will discuss what is currently known about biological roles of PKC? and prospects for targeting PKC? in human disease. ..
  61. Pfeifhofer Obermair C, Albrecht Schgoer K, Peer S, Nairz M, Siegmund K, Klepsch V, et al. Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice. Cell Commun Signal. 2016;14:14 pubmed publisher
    ..typhimurium infection, and acts as an essential link between TLR4/IFNgammaR signaling and selective suppression of the anti-inflammatory cytokine IL-10 at the onset of CAM differentiation in the course of a bacterial infection. ..
  62. Okimoto R, Lin L, Olivas V, Chan E, Markegard E, Rymar A, et al. Preclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancer. Proc Natl Acad Sci U S A. 2016;113:13456-13461 pubmed
    ..Our study provides a biological rationale and potential polytherapy strategy to aid the deployment of PLX8394 in lung cancer patients. ..
  63. Li Z, Liu J, Li J, Kong Y, Sandusky G, Rao X, et al. Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in mice. J Biol Chem. 2017;292:17461-17472 pubmed publisher
    ..We conclude that Plk1 overexpression may contribute to tumor formation by both inducing chromosomal instability and suppressing the DDR pathway. ..
  64. Kim A, Back J, Zhu Y, Tang X, Yardley N, Kim K, et al. AKT1 Activation is Obligatory for Spontaneous BCC Tumor Growth in a Murine Model that Mimics Some Features of Basal Cell Nevus Syndrome. Cancer Prev Res (Phila). 2016;9:794-802 pubmed
    ..Our data demonstrate an obligatory role for AKT1 in BCC growth, and targeting AKT may help reduce BCC tumor burden in BCNS patients. Cancer Prev Res; 9(10); 794-802. ©2016 AACR. ..
  65. Cui S, Zhang K, Li C, Chen J, Pan Y, Feng B, et al. Methylation-associated silencing of microRNA-129-3p promotes epithelial-mesenchymal transition, invasion and metastasis of hepatocelluar cancer by targeting Aurora-A. Oncotarget. 2016;7:78009-78028 pubmed publisher
    ..Therefore, miR-129-3p may be a novel prognostic biomarker and potential therapeutic target for HCC. ..
  66. Russo P, Hood B, Bateman N, Conrads T. Quantitative Mass Spectrometry by Isotope Dilution and Multiple Reaction Monitoring (MRM). Methods Mol Biol. 2017;1606:313-332 pubmed publisher
    ..Ataxia telangiectasia mutated (ATM) phosphorylates several key proteins that initiate activation of the DNA damage checkpoint leading to cell cycle arrest. ..
  67. Yang B, Jia Y, Jia Z, Wang W, Song X, Li Y, et al. The cyclin-dependent kinase 2 (CDK2) mediates hematopoiesis through G1-to-S transition in Chinese mitten crab Eriocheir sinensis. Dev Comp Immunol. 2018;81:156-166 pubmed publisher
    ..sinensis. ..
  68. Wang J, Zhang X, Li Q, Wang K, Wang Y, Jiao J, et al. MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD. Circ Res. 2015;117:352-63 pubmed publisher
    ..Our results reveal a novel myocardial necrosis regulation model, which is composed of H19, miR-103/107, and FADD. Modulation of their levels may provide a new approach for preventing myocardial necrosis. ..
  69. Gueguen C, Bouley J, Moussu H, Luce S, Duchateau M, Chamot Rooke J, et al. Changes in markers associated with dendritic cells driving the differentiation of either TH2 cells or regulatory T cells correlate with clinical benefit during allergen immunotherapy. J Allergy Clin Immunol. 2016;137:545-58 pubmed publisher
  70. Liao Y, Feng Y, Shen J, Gao Y, Cote G, Choy E, et al. Clinical and biological significance of PIM1 kinase in osteosarcoma. J Orthop Res. 2016;34:1185-94 pubmed publisher
    ..2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1185-1194, 2016. ..
  71. Zhang L, Chen W, Hu Y, Wu X, Nie P, Chang M. TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. Fish Shellfish Immunol. 2016;54:135-43 pubmed publisher
    ..Collectively, these data support that zebrafish TBK1L negatively regulates RLRs-MAVS-TBK1 pathway. ..
  72. Dernayka L, Rauch N, Jarboui M, Zebisch A, Texier Y, Horn N, et al. Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF. Cell Signal. 2016;28:1432-9 pubmed publisher
    ..The phosphorylation of S614 is mitogen inducible and the result of autophosphorylation. These data suggest that phosphorylation at this site is inhibitory, and part of the physiological shut-down mechanism of BRAF signalling. ..
  73. Peters M, Minton A, Phanstiel IV O, Gilmour S. A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors. Med Sci (Basel). 2018;6: pubmed publisher
    ..These data indicate that mutant BRAF melanoma cells are more dependent on the PTS compared to BRAFWT melanoma cells, resulting in greater sensitivity to the PTS-targeted cytotoxic AP compound. ..
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