PRKAA1

Summary

Gene Symbol: PRKAA1
Description: protein kinase AMP-activated catalytic subunit alpha 1
Alias: AMPK, AMPKa1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase, catalytic alpha-1 chain, ACACA kinase, AMP -activate kinase alpha 1 subunit, AMP-activated protein kinase, catalytic, alpha-1, AMPK alpha 1, AMPK subunit alpha-1, HMGCR kinase, acetyl-CoA carboxylase kinase, hydroxymethylglutaryl-CoA reductase kinase, protein kinase, AMP-activated, alpha 1 catalytic subunit, tau-protein kinase PRKAA1
Species: human

Top Publications

  1. pmc Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    Duygu Sag
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Immunol 181:8633-41. 2008
  2. doi MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1
    Hong Sheng Zhang
    College of Life Science and Bioengineering, Beijing University of Technology, Pingleyuan 100, District of Chaoyang, Beijing, China
    Biochim Biophys Acta 1823:1017-23. 2012
  3. doi Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation
    L A Pradelli
    INSERM, U895, Centre Méditerranéen de Médecine Moléculaire C3M, équipe 3 AVENIR, Nice, France
    Oncogene 29:1641-52. 2010
  4. doi A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1
    Yongyong Shi
    Bio X Institutes, Ministry of Education Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, China
    Nat Genet 43:1215-8. 2011
  5. pmc Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase
    Veronica Nin
    Department of Anesthesiology and Kogod Aging Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 287:23489-501. 2012
  6. ncbi Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus
    Alejandro Vazquez-Martin
    Unit of Translational Research, Catalan Institute of Oncology Girona, Girona, Spain
    Cell Cycle 10:1295-302. 2011
  7. pmc AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals
    S Y Kim
    Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
    Cell Death Dis 3:e357. 2012
  8. pmc Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259
    Amardeep S Dhillon
    The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom
    Mol Cell Biol 22:3237-46. 2002
  9. pmc 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity
    J A Thorson
    Center for Immunology and Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    Mol Cell Biol 18:5229-38. 1998
  10. pmc Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection
    R Anthony Barnitz
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892 1892, USA
    J Virol 84:6410-24. 2010

Research Grants

  1. Inderjit Singh; Fiscal Year: 2014
  2. REUBEN JAMES SHAW; Fiscal Year: 2015
  3. Katja A Lamia; Fiscal Year: 2016
  4. Efficacy Of Metformin In The Methylnitrosourea-Induced Model Of ER
    Terisa Davis; Fiscal Year: 2013
  5. REUBEN JAMES SHAW; Fiscal Year: 2016
  6. Bayar Thimmapaya; Fiscal Year: 2016
  7. Rong Tian; Fiscal Year: 2015
  8. ADSS1 inactivation as a promoter of tumor metabolism and lung carcinogenesis
    Christopher R Herzog; Fiscal Year: 2010
  9. Nissim Hay; Fiscal Year: 2016
  10. Min Du; Fiscal Year: 2014

Detail Information

Publications1404 found, 100 shown here

  1. pmc Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    Duygu Sag
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Immunol 181:8633-41. 2008
    Herein, we demonstrate a role of AMP-activated protein kinase (AMPK) as a potent counterregulator of inflammatory signaling pathways in macrophages. Stimulation of macrophages with anti-inflammatory cytokines (i.e...
  2. doi MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1
    Hong Sheng Zhang
    College of Life Science and Bioengineering, Beijing University of Technology, Pingleyuan 100, District of Chaoyang, Beijing, China
    Biochim Biophys Acta 1823:1017-23. 2012
    ..SIRT1 caused by miR-217 enhanced Tat-induced phosphorylation of IKK and p65-NFkB and also exacerbated the loss of AMPK phosphorylation triggered by Tat...
  3. doi Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation
    L A Pradelli
    INSERM, U895, Centre Méditerranéen de Médecine Moléculaire C3M, équipe 3 AVENIR, Nice, France
    Oncogene 29:1641-52. 2010
    ..This sensitization is controlled through the adenosine monophosphate (AMP)-activated protein kinase (AMPK), which is the central energy-sensing system of the cell...
  4. doi A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1
    Yongyong Shi
    Bio X Institutes, Ministry of Education Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, China
    Nat Genet 43:1215-8. 2011
    ..1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9))...
  5. pmc Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase
    Veronica Nin
    Department of Anesthesiology and Kogod Aging Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 287:23489-501. 2012
    ..an increase in cAMP/PKA activity resulted in the dissociation of SIRT1 and DBC1 in an AMP-activated protein kinase (AMPK)-dependent manner. Pharmacological AMPK activation led to SIRT1 activation by a DBC1-dependent mechanism...
  6. ncbi Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus
    Alejandro Vazquez-Martin
    Unit of Translational Research, Catalan Institute of Oncology Girona, Girona, Spain
    Cell Cycle 10:1295-302. 2011
    AMP-activated protein kinase (AMPK) is being primarily studied as a central metabolic stress sensor, which regulates cell survival and growth-related metabolic pathways to preserve intracellular ATP levels in response to energy ..
  7. pmc AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals
    S Y Kim
    Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
    Cell Death Dis 3:e357. 2012
    ..In the present study, we have provided evidences that AMP-activated protein kinase (AMPK)-α1 has a pivotal role for activating TAK1, and thereby regulate NF-κB-dependent gene expressions in inflammatory ..
  8. pmc Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259
    Amardeep S Dhillon
    The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom
    Mol Cell Biol 22:3237-46. 2002
    ..Using RafS259 mutants we also demonstrate that Raf-1 is the sole target for PKA inhibition of ERK and ERK-induced gene expression, and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation...
  9. pmc 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity
    J A Thorson
    Center for Immunology and Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    Mol Cell Biol 18:5229-38. 1998
    ..This supports a paradigm in which the effects of phosphorylation on serine as well as tyrosine residues are mediated by inducible protein-protein interactions...
  10. pmc Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection
    R Anthony Barnitz
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892 1892, USA
    J Virol 84:6410-24. 2010
    ..Inhibition of PKA activity during HIV-1 infection abrogates Vpr cell cycle arrest. These findings provide new insight into the signaling event that activates Vpr cell cycle arrest, ultimately leading to the death of infected T cells...
  11. doi Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif
    Kotaro Shirakawa
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
    Nat Struct Mol Biol 15:1184-91. 2008
    ..These data imply that PKA-mediated phosphorylation of A3G can regulate the interaction between A3G and Vif...
  12. ncbi IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner
    Atsushi Suzuki
    Cancer Physiology Project, National Cancer Center Research Institute East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Biochem Biophys Res Commun 324:986-92. 2004
    Serine/threonine protein kinase AMP-activated protein kinase (AMPK) is a key metabolic stress-responsive factor that promotes the adaptation of cells to their microenvironment...
  13. ncbi AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
    Russell G Jones
    Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell 18:283-93. 2005
    ..The glucose-dependent checkpoint occurs at the G(1)/S boundary and is regulated by AMP-activated protein kinase (AMPK). This cell-cycle arrest occurs despite continued amino acid availability and active mTOR...
  14. pmc TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells
    Griselda Herrero-Martin
    Cell Signalling Department, Centro Andaluz de Biologia Molecular y Medicina Regenerativa CABIMER, Consejo Superior de Investigaciones Cientificas, Avenida Americo Vespucio s n, Sevilla, Spain
    EMBO J 28:677-85. 2009
    ..TRAIL-induced autophagy is mediated by the AMP-activated protein kinase (AMPK) that inhibits mammalian target of rapamycin complex 1, a potent inhibitor of autophagy...
  15. doi Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation
    Alexandre Puissant
    INSERM 895, Team 2 Cell Death Differentiation and Cancer, Laboratoire d OncoHématologie, Centre Hospitalier Universitaire de Nice, Nice, France
    Cancer Res 70:1042-52. 2010
    ..JNK inhibition or p62 knockdown prevented RSV-mediated autophagy and antileukemic effects. RSV also stimulated AMPK, thereby inhibiting the mTOR pathway...
  16. doi Ppm1E is an in cellulo AMP-activated protein kinase phosphatase
    Martin Voss
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Cell Signal 23:114-24. 2011
    Activation of 5'-AMP-activated protein kinase (AMPK) is believed to be the mechanism by which the pharmaceuticals, metformin and phenformin, exert their beneficial effects for treatment of type 2 diabetes...
  17. pmc The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
    Maria M Mihaylova
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Cell Biol 13:1016-23. 2011
    One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases...
  18. ncbi Mammalian AMP-activated protein kinase subfamily
    D Stapleton
    St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    J Biol Chem 271:611-4. 1996
    The mammalian 5'-AMP-activated protein kinase (AMPK) is related to a growing family of protein kinases in yeast and plants that are regulated by nutritional stress...
  19. ncbi Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
    S A Hawley
    Biochemistry Department, The University, Dundee DD1 4HN, Scotland, United Kingdom
    J Biol Chem 271:27879-87. 1996
    ..A., Selbert, M. A., Goldstein, E. G., Edelman, A. M., Carling, D., and Hardie, D. G. (1995) J. Biol. Chem. 270, 27186-27191)...
  20. pmc Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase
    K R Hallows
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 105:1711-21. 2000
    ..The alpha1 (catalytic) subunit of AMP-activated protein kinase (AMPK) was identified as a dominant and novel interacting protein...
  21. ncbi TSC2 mediates cellular energy response to control cell growth and survival
    Ken Inoki
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 115:577-90. 2003
    ..Under energy starvation conditions, the AMP-activated protein kinase (AMPK) phosphorylates TSC2 and enhances its activity...
  22. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
    ..the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase (AMPK)...
  23. pmc The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    Reuben J Shaw
    Department of Systems Biology, Harvard Medical School, and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:3329-35. 2004
    AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status found in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP ratio...
  24. ncbi Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
    Simon A Hawley
    Division of Molecular Physiology University of Dundee, Dundee, Scotland, United Kingdom
    Cell Metab 2:9-19. 2005
    The AMP-activated protein kinase (AMPK) is a critical regulator of energy balance at both the cellular and whole-body levels. Two upstream kinases have been reported to activate AMPK in cell-free assays, i.e...
  25. pmc AMPK phosphorylation of raptor mediates a metabolic checkpoint
    Dana M Gwinn
    Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell 30:214-26. 2008
    b>AMPK is a highly conserved sensor of cellular energy status that is activated under conditions of low intracellular ATP...
  26. pmc Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process
    Roland Scholz
    Department of Biology, Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland
    J Biol Chem 285:25753-66. 2010
    ..TAK1-TAB1 complex capable of directly activating full-length heterotrimeric mammalian AMP-activated protein kinase (AMPK) in vitro...
  27. pmc Characterization of the CaMKKβ-AMPK signaling complex
    Michelle F Green
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27713, USA
    Cell Signal 23:2005-12. 2011
    The AMP-activated protein kinase (AMPK) is a critical regulator of energy homeostasis, and is a potential target for treatment of metabolic diseases as well as cancer...
  28. pmc AMPKα modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer
    Yon Hui Kim
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 72:2512-21. 2012
    ..Through this approach, we identified the central metabolic regulator AMP-activated protein kinase (AMPK)α as a potential functional target in Asian gastric cancer...
  29. ncbi AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress
    Daisuke Nagata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 278:31000-6. 2003
    AMP-activated protein kinase (AMPK) is a stress-activated protein kinase that is regulated by hypoxia and other cellular stresses that result in diminished cellular ATP levels...
  30. ncbi Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase
    A B Sprenkle
    Howard Hughes Medical Institute, Department of Medicine, University of Virginia, Charlottesville 22908, USA
    FEBS Lett 403:254-8. 1997
    ..One major peak of activity was detected and identified as AMP-activated protein kinase (AMPK) by immunodepletion experiments...
  31. ncbi Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    FASEB J 19:1146-8. 2005
    We tested the hypothesis that 5'AMP-activated protein kinase (AMPK) plays an important role in regulating the acute, exercise-induced activation of metabolic genes in skeletal muscle, which were dissected from whole-body alpha2- and ..
  32. ncbi [Effects of globular adiponectin, glucose and free fatty acid on AMPK and ACC phosphorylation in INS-1 beta cells]
    Yu Tong
    Department of Endocrinology, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 38:609-13. 2006
    ..fatty acid at different concentrations on phosphorylation of adenosine-5'-monophosphate activated protein kinase(AMPK) and acetyl CoA carboxylase (ACC) in INS-1 cells, and effects of globular adiponectin on phosphorylation of AMPK ..
  33. pmc Nitric oxide and AMPK cooperatively regulate PGC-1 in skeletal muscle cells
    Vitor A Lira
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    J Physiol 588:3551-66. 2010
    ..Further, we have shown that nitric oxide interacts with the metabolic sensor enzyme, AMPK. Therefore, we tested the hypothesis that nitric oxide and AMPK act synergistically to upregulate PGC-1α mRNA ..
  34. pmc AMP-activated protein kinase inhibits TREK channels
    Orsolya Kréneisz
    Department of Physiology and Neurobiology, University of Connecticut, 75 N Eagleville Rd Unit 3156, Storrs Mansfield, CT 06269 9011, USA
    J Physiol 587:5819-30. 2009
    AMP-activated protein kinase (AMPK) is a serine/threonine kinase activated by conditions that increase the AMP : ATP ratio...
  35. ncbi Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration
    Li Zhang
    NMR Laboratory for Physiological Chemistry, Divivion of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Am J Physiol Heart Circ Physiol 293:H457-66. 2007
    AMP-activated protein kinase (AMPK) acts as a cellular energy sensor: it responds to an increase in AMP concentration ([AMP]) or the AMP-to-ATP ratio (AMP/ATP)...
  36. ncbi Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes
    Qingwu W Shen
    Department of Animal Science, Interdepartmental Molecular and Cellular Life Science Program, University of Wyoming, Laramie, WY 82071, USA
    Am J Physiol Cell Physiol 293:C1395-403. 2007
    ..ALA stimulates glucose uptake and increases insulin sensitivity by the activation of AMP-activated protein kinase (AMPK) in skeletal muscle, but the underlying mechanism for AMPK activation is unknown...
  37. ncbi Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177
    Peter F Mount
    Austin Research Institute, Austin Health, University of Melbourne, Heidelberg 3084, Victoria, Australia
    Am J Physiol Renal Physiol 289:F1103-15. 2005
    ..The energy sensor AMP-activated protein kinase (AMPK) is activated by a rising AMP-to-ATP ratio, but its role in acute renal ischemia is unknown...
  38. doi Regulation of visceral and subcutaneous adipocyte lipolysis by acute AICAR-induced AMPK activation
    Nicole M Anthony
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Obesity (Silver Spring) 17:1312-7. 2009
    This study investigated the role of adenosine monophosphate-activated protein kinase (AMPK) in the regulation of lipolysis in visceral (VC) and subcutaneous (SC) rat adipocytes and the molecular mechanisms involved in this process...
  39. doi The role of phospho-adenosine monophosphate-activated protein kinase and vascular endothelial growth factor in a model of chronic heart failure
    Florian Heidrich
    Department of Thoracic, Cardiac and Vascular Surgery, University of Goettingen, Germany
    Artif Organs 34:969-79. 2010
    ..Therefore, two biomarkers, adenosine monophosphate-activated protein kinase (AMPK) and vascular endothelial growth factor-A (VEGF-A) were examined to reveal their role during chronic ischemic ..
  40. doi AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase
    Boubacar Benziane
    Dept of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Am J Physiol Cell Physiol 297:C1554-66. 2009
    Muscle contraction and metabolic stress are potent activators of AMP-activated protein kinase (AMPK). AMPK restores energy balance by activating processes that produce energy while inhibiting those that consume energy...
  41. ncbi Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphorylation
    David M Thomson
    Human Performance Laboratory, 363 Ward Sports Medicine Bldg, East Carolina Univ, Greenville, NC 27858, USA
    J Appl Physiol (1985) 98:557-64. 2005
    ..Because 5'-AMP-activated protein kinase (AMPK) activity is thought to inhibit skeletal muscle protein synthesis and may therefore modulate muscle mass and ..
  42. pmc Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells
    A M Woollhead
    Centre for Ion Channels and Cell Signalling, Division of Basic Medical Sciences, St George s, University of London, London, UK
    Br J Pharmacol 151:1204-15. 2007
    AMP-activated protein kinase (AMPK) is activated by metformin, phenformin, and the AMP mimetic, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR)...
  43. ncbi AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females
    Gregory R Steinberg
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria, Australia 3065
    J Clin Endocrinol Metab 89:4575-80. 2004
    ..AMP-activated protein kinase (AMPK) is an important regulator of fatty acid (FA) metabolism in skeletal muscle...
  44. ncbi Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
    Am J Physiol Endocrinol Metab 290:E500-8. 2006
    ..We investigated the effects of adrenergic stimulation and AMPK activation in vitro and in circumstances where AMPK activity and catecholamines are physiologically elevated in ..
  45. pmc Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels
    Suthat Liangpunsakul
    Departments of 1Medicine, Indiana University School of Medicine, Indianapolis, Indiana
    Am J Physiol Gastrointest Liver Physiol 298:G1004-12. 2010
    Ethanol treatment of cultured hepatoma cells and of mice inhibited the activity of AMP-activated protein kinase (AMPK)...
  46. doi eNOS activation mediated by AMPK after stimulation of endothelial cells with histamine or thrombin is dependent on LKB1
    Brynhildur Thors
    Institute of Pharmacy, Pharmacology and Toxicology, University of Iceland, Hagi Hofsvallagotu 53, Reykjavik, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Biochim Biophys Acta 1813:322-31. 2011
    Reports on the role of AMP-activated protein kinase (AMPK) in thrombin-mediated activation of endothelial nitric-oxide synthase (eNOS) in endothelial cells have been conflicting...
  47. pmc Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance
    Matthew R Hayes
    Graduate Group of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:2175-82. 2009
    The fuel-sensing enzyme AMP-activated protein kinase (AMPK) has been implicated in central nervous system control of energy balance...
  48. pmc AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies
    Valérie Vingtdeux
    Litwin Zucker Research Center for the Study of Alzheimer s Disease, The Feinstein Institute for Medical Research, North Shore LIJ, 350 Community Drive, Manhasset, NY 11030, USA
    Acta Neuropathol 121:337-49. 2011
    ..AMP-activated protein kinase (AMPK) is a metabolic sensor expressed in most mammalian cell types...
  49. ncbi Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle
    Jørgen F P Wojtaszewski
    Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 51:284-92. 2002
    5'-AMP-activated protein kinase (AMPK) functions as a metabolic switch in mammalian cells and can be artificially activated by 5-aminoimidazole-4-carboxamide (AICA)-riboside...
  50. ncbi Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase
    Samar I Itani
    Diabetes and Metabolism Unit and Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Diabetes 52:1635-40. 2003
    ..Activation of the energy-sensing enzyme AMP-activated protein kinase (AMPK) has been shown to increase insulin-independent glucose transport into skeletal muscle in response to such stimuli ..
  51. ncbi Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization
    Jagdip S Jaswal
    Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton Alberta T6G 2H7, Canada
    Am J Physiol Heart Circ Physiol 293:H1107-14. 2007
    p38 mitogen-activated protein kinase (MAPK) and 5'-AMP-activated protein kinase (AMPK) are activated by metabolic stresses and are implicated in the regulation of glucose utilization and ischemia-reperfusion (IR) injury...
  52. pmc Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells
    Zhonglin Xie
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Circulation 117:952-62. 2008
    ..used antidiabetes drugs, is reported to exert its therapeutic effects by activating AMP-activated protein kinase (AMPK); however, the mechanism by which metformin activates AMPK is poorly defined...
  53. pmc Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation
    Xuan Fu
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
    PLoS ONE 3:e2009. 2008
    ..ATM has been reported to phosphorylate the alpha subunit of AMP-activated protein kinase (AMPK), which senses AMP/ATP ratio in cells, and can be activated by upstream kinases...
  54. pmc Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis
    Bilal Omar
    Lund University, Biomedical Center, C11 Department of Experimental Medical Science, 221 84 Lund, Sweden
    Cell Signal 21:760-6. 2009
    AMP-activated protein kinase (AMPK) is an important regulator of cellular energy status. In adipocytes, stimuli that increase intracellular cyclic AMP (cAMP) have also been shown to increase the activity of AMPK...
  55. pmc AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes
    Shuangxi Wang
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Circ Res 106:1117-28. 2010
    AMP-activated protein kinase (AMPK) is an energy sensor and ubiquitously expressed in vascular cells. Recent studies suggest that AMPK activation improves endothelial function by counteracting oxidative stress in endothelial cells...
  56. ncbi AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment
    Gregory R Steinberg
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 284:E648-54. 2003
    ..Acute stimulation of AMP-activated protein kinase (AMPK) results in a repartitioning of FA toward oxidation and away from esterification in rodent soleus muscle and has ..
  57. ncbi Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo
    Asish K Saha
    Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Biochem Biophys Res Commun 314:580-5. 2004
    ..To assess these questions, we examined the effects of pioglitazone, administered orally to intact rats, on AMPK phosphorylation (AMPK-P) (a measure of its activation) and acetyl CoA carboxylase (ACC) activity and malonyl CoA ..
  58. ncbi AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise
    Meghan Kelly
    Diabetes Unit, Section of Endocrinology, Boston Medical Center and Departments of Medicine and Physiology, Boston University School of Medicine, Boston, MA 02118, USA
    Biochem Biophys Res Commun 320:449-54. 2004
    Following exercise, AMP-activated protein kinase (AMPK) activity is increased several fold in rat liver and adipose tissue as well as muscle; however, the mechanism by which this occurs is not known...
  59. ncbi AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells
    Mengwei Zang
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:47898-905. 2004
    The antidiabetic drug metformin stimulates AMP-activated protein kinase (AMPK) activity in the liver and in skeletal muscle...
  60. ncbi Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy
    Hong Liang Li
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing, 100005, PR China
    J Cell Biochem 100:1086-99. 2007
    Recent in vitro studies suggest that adenosine monophosphate (AMP)-activated protein kinase (AMPK) exerts inhibitory effects on cardiac hypertrophy...
  61. pmc AMP-activated protein kinase is involved in hormone-induced mouse oocyte meiotic maturation in vitro
    Jing Chen
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA
    Dev Biol 313:47-57. 2008
    We have previously shown that AMP-activated protein kinase (AMPK) can induce the resumption of meiosis in mouse oocytes maintained in meiotic arrest in vitro...
  62. pmc AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance
    Marie Soleil Gauthier
    Diabetes and Metabolism Unit, Department of Medicine Section of Endocrinology, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Biol Chem 283:16514-24. 2008
    AMP-activated protein kinase (AMPK) is activated in adipocytes during exercise and other states in which lipolysis is stimulated. However, the mechanism(s) responsible for this effect and its physiological relevance are unclear...
  63. doi AMP-activated protein kinase influences metabolic remodeling in H9c2 cells hypertrophied by arginine vasopressin
    Ramesh Saeedi
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Department of Pathology and Laboratory Medicine, University of British Columbia St Paul s Hospital, Vancouver, British Columbia, Canada V6Z 1Y6
    Am J Physiol Heart Circ Physiol 296:H1822-32. 2009
    ..The activation of AMP-activated protein kinase (AMPK) observed in hypertrophied hearts provides one potential mechanism for the acceleration of glycolysis...
  64. doi A novel role for AMP-kinase in the regulation of the Na+/I--symporter and iodide uptake in the rat thyroid gland
    Bruno M Andrade
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Am J Physiol Cell Physiol 300:C1291-7. 2011
    The aim of this study was to investigate the role of AMP-kinase (AMPK) in the regulation of iodide uptake by the thyroid gland...
  65. pmc Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle
    J B Birk
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, 13 Universitetsparken, 2100 Copenhagen Ø, Denmark
    J Physiol 577:1021-32. 2006
    5'AMP-activated protein kinase (AMPK) is a key regulator of cellular metabolism and is regulated in muscle during exercise...
  66. ncbi AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B
    Luc Bertrand
    Division of Cardiology, School of Medicine, Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol Heart Circ Physiol 291:H239-50. 2006
    ..Part of these metabolic effects is thought to be mediated by the activation of AMP-activated protein kinase (AMPK)...
  67. ncbi The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes
    Karalyn D Folmes
    Cardiovascular Research Group, Faculty of Medicine and Dentistry, University of Alberta, 474 Heritage Medical Research Centre, Edmonton, Alberta, Canada
    Am J Physiol Heart Circ Physiol 293:H3456-64. 2007
    Although mutations in the gamma-subunit of AMP-activated protein kinase (AMPK) can result in excessive glycogen accumulation and cardiac hypertrophy, the mechanisms by which this occurs have not been well defined...
  68. pmc Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells
    Stephen P Soltoff
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02111, USA
    Am J Physiol Cell Physiol 295:C590-9. 2008
    ..of extracellular signal-regulated kinase-1/2 (ERK1/2) that is normally mediated by AMP-activated protein kinase (AMPK)...
  69. pmc Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations
    Arie Gruzman
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
    Rev Diabet Stud 6:13-36. 2009
    ..The adenosine monophosphate-activated protein kinase (AMPK) is an important regulatory protein for cellular energy balance and is considered a master switch of glucose and ..
  70. pmc Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells
    Hui Li
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Renal Physiol 299:F167-77. 2010
    The metabolic sensor AMP-activated protein kinase (AMPK) regulates several transport proteins, potentially coupling transport activity to cellular stress and energy levels...
  71. doi Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes
    Amelie Gormand
    Protein Phosphorylation Research Group, Department of Experimental Medical Science, Lund University, BMC C11, SE 221 84 Lund, Sweden
    J Cell Biochem 112:1364-75. 2011
    AMP-activated protein kinase (AMPK) is a serine/threonine kinase that regulates cellular and whole body energy homeostasis. In adipose tissue, activation of AMPK has been demonstrated in response to a variety of extracellular stimuli...
  72. doi Expression and activity of the 5'-adenosine monophosphate-activated protein kinase pathway in selected tissues during chicken embryonic development
    M Proszkowiec-Weglarz
    USDA, Agricultural Research Service, Animal and Natural Resources Institute, Beltsville, MD 20705 2350, USA
    Poult Sci 88:159-78. 2009
    The 5'-adenosine monophosphate-activated protein kinase (AMPK) is a highly conserved serine-threonine protein kinase and a key part of a kinase-signaling cascade that senses cellular energy status (adenosine monophosphate:adenosine ..
  73. doi Suppression of 5'-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts
    Clifford D L Folmes
    Cardiovascular Research Group and Department of Pediatrics and Pharmacology, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Heart Circ Physiol 297:H313-21. 2009
    Activation of 5'-AMP-activated protein kinase (AMPK) may benefit the heart during ischemia-reperfusion by increasing energy production...
  74. pmc AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass
    M Shah
    Department of Veterinary Basic Sciences Royal Veterinary College, Royal College Street, London, NW1 OTU, UK
    Bone 47:309-19. 2010
    Adenosine 5'-monophosphate-activated protein kinase (AMPK), a regulator of energy homeostasis, has a central role in mediating the appetite-modulating and metabolic effects of many hormones and antidiabetic drugs metformin and glitazones...
  75. ncbi Long-term exercise stimulates adenosine monophosphate-activated protein kinase activity and subunit expression in rat visceral adipose tissue and liver
    Kazuhiro Takekoshi
    Department of Clinical Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305 8575, Japan
    Metabolism 55:1122-8. 2006
    Adenosine monophosphate-activated protein kinase (AMPK) is activated in response to adenosine triphosphate depletion caused by the metabolic and nutritional state...
  76. pmc Adenosine monophosphate activated protein kinase inhibition is protective in both sexes after experimental stroke
    Jun Li
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Neurosci Lett 482:62-5. 2010
    ..Adenosine monophosphate activated protein kinase (AMPK) is an important energy sensor that is activated in times of energy demand...
  77. ncbi Regulation of chemosensory receptor expression and sensory signaling by the KIN-29 Ser/Thr kinase
    Anne Lanjuin
    Department of Biology and Volen Center for Complex Systems, Brandeis University, MS 008, 415 South Street, Waltham, MA 02454, USA
    Neuron 33:369-81. 2002
    ..kin-29 encodes a Ser/Thr kinase with similarity to the MARK and AMPK/SNF1 family of kinases...
  78. ncbi Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast
    Seung Pyo Hong
    Department of Genetics and Development, Columbia University, 701 W 168th Street, New York, NY 10032, USA
    J Biol Chem 280:21804-9. 2005
    The Snf1/AMP-activated protein kinase (AMPK) family is important for metabolic regulation in response to stress. In the yeast Saccharomyces cerevisiae, the Snf1 kinase cascade comprises three Snf1-activating kinases, Pak1, Tos3, and Elm1...
  79. ncbi Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts
    Ken Shinmura
    Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Mol Cell Cardiol 39:285-96. 2005
    ..There was no difference in myocardial expression levels of AMP-activated kinase (AMPK) but AMPK-alpha phosphorylated at Thr172 increased with CR in both Y and O...
  80. doi Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
    Mohammed H Mukhtar
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Am J Physiol Regul Integr Comp Physiol 294:R766-74. 2008
    ..which is metabolized by hepatocytes to an AMP analog, and causes activation of AMP-activated protein kinase (AMPK) and depletion of ATP...
  81. doi Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein
    Y Takagi
    Department of Pathology and Oncology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Oncogene 27:5339-47. 2008
    ..These results suggest that Flcn-FnipL/Fnip2 and Flcn-Fnip1 complexes positively regulate S6K1 phosphorylation and that FnipL/Fnip2 provides an important clue to elucidating the function of Flcn and the pathogenesis of BHD...
  82. doi BLX-1002, a novel thiazolidinedione with no PPAR affinity, stimulates AMP-activated protein kinase activity, raises cytosolic Ca2+, and enhances glucose-stimulated insulin secretion in a PI3K-dependent manner
    Fan Zhang
    Diabetes Research Center, Dept of Internal Medicine, Karolinska Institutet, South Hospital, SE 11883 Stockholm, Sweden
    Am J Physiol Cell Physiol 296:C346-54. 2009
    ..Stimulation of the beta-cells with BLX-1002 also induced activation of AMP-activated protein kinase (AMPK) at high glucose...
  83. doi AMPK activation is fiber type specific in human skeletal muscle: effects of exercise and short-term exercise training
    Robert S Lee-Young
    Department of Physiology, University of Melbourne, Parkville, Victoria
    J Appl Physiol (1985) 107:283-9. 2009
    AMP-activated protein kinase (AMPK) has been extensively studied in whole muscle biopsy samples of humans, yet the fiber type-specific expression and/or activation of AMPK is unknown...
  84. doi Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice
    Masahito Takikawa
    College of Bioscience and Biotechnology, Chubu University, Kasugai, Aichi 487 8501, Japan
    J Nutr 140:527-33. 2010
    ..that dietary BBE ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase (AMPK). Dietary BBE significantly reduced the blood glucose concentration and enhanced insulin sensitivity...
  85. pmc Improved myocardial perfusion in chronic diabetic mice by the up-regulation of pLKB1 and AMPK signaling
    Claudia Kusmic
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Cell Biochem 109:1033-44. 2010
    ..The restoration of microvascular function suggests a new therapeutic approach to even advanced cardiac microvascular derangement in diabetes...
  86. pmc Targeting of renal proximal tubule Na,K-ATPase by salt-inducible kinase
    Mary Taub
    Department of Biochemistry, University at Buffalo, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Biochem Biophys Res Commun 393:339-44. 2010
    ..SIKs are recently discovered members of the AMP-activated Protein Kinase (AMPK) family, which regulate salt homeostasis and metabolism in a number of tissues...
  87. pmc Metformin: a therapeutic opportunity in breast cancer
    Ana M Gonzalez-Angulo
    Department of Breast Medical Oncology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:1695-700. 2010
    ..which is activated when nutrients are available, and the adenosine mono-phosphate-activated protein kinase (AMPK) pathway, activated when cells are starved for carbohydrates...
  88. pmc LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity
    Xiaojian Xu
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    BMC Cell Biol 11:77. 2010
    ..LKB1 encodes a serine/threonine kinase that plays an important role in regulating energy metabolism through the AMPK/mTOR signaling pathway. In addition, LKB1 is homologous to PAR-4, a polarity protein first described in C...
  89. pmc Participation of hindbrain AMP-activated protein kinase in glucoprivic feeding
    Ai Jun Li
    Programs in Neuroscience, Washington State University, Pullman, Washington, USA
    Diabetes 60:436-42. 2011
    To examine the role of AMP-activated protein kinase (AMPK) in the control of glucoprivic feeding by hindbrain catecholamine neurons.
  90. pmc The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish
    Yme U van der Velden
    Department of Molecular Genetics, Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 108:4358-63. 2011
    ..LKB1 has many targets, including the AMP-activated protein kinase (AMPK) that is phosphorylated under low-energy conditions...
  91. doi Taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats
    Carina S Solon
    Laboratory of Cell Signaling, University of Campinas, DCM FCM UNICAMP, Campinas, SP, 13084 970, Brazil
    Amino Acids 42:2403-10. 2012
    ..food intake and locomotor activity, and activates signal transduction through the Akt/FOXO1, JAK2/STAT3 and mTOR/AMPK/ACC signaling pathways. These effects are accompanied by the modulation of expression of NPY...
  92. pmc Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein
    Charles E Wood
    Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, United States
    J Agric Food Chem 60:81-6. 2012
    ..metabolism, including peroxisome proliferator-activated receptor (PPAR)-γ and AMP-activated protein kinase (AMPK) signaling, adipocytokine expression, triglyceride synthesis, and lipase activity...
  93. ncbi Activation of the metabolic sensor-AMP activated protein kinase reverses impairment of angiogenesis in aging myocardial microvascular endothelial cells. Implications for the aging heart
    A Ahluwalia
    Southern California Intitute for Research and Education, VA Long Beach Health Care System, CA 90822, USA
    J Physiol Pharmacol 62:583-7. 2011
    ..gene expression in aging MMECs using a chemical activator of the metabolic sensor - AMP activated protein kinase (AMPK)...
  94. pmc In vitro substrate phosphorylation by Ca²⁺/calmodulin-dependent protein kinase kinase using guanosine-5'-triphosphate as a phosphate donor
    Saki Yurimoto
    Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    BMC Biochem 13:27. 2012
    ..kinase (CaMKK) phosphorylates and activates particular downstream protein kinases - including CaMKI, CaMKIV, and AMPK- to stimulate multiple Ca2+-signal transduction pathways...
  95. pmc Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle
    Tizhong Shan
    Department of Animal Science, Purdue University, West Lafayette, IN 47907, USA
    FASEB J 27:1981-9. 2013
    ..Within the muscle, Mstn(-/-) leads to increased expression of AMPK and its phosphorylation, which subsequently activates PGC1α and Fndc5...
  96. pmc P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death
    Shu Bian
    Department of Gastroenterology, Provincial Hospital affiliated to Shandong University, Jinan, People s Republic of China
    PLoS ONE 8:e60184. 2013
    ..We have previously reported that chronic exposure of tumor cells to ATP provokes P2X7-mediated tumor cell death, by as yet incompletely defined molecular mechanisms...
  97. doi Salsalate and adiponectin ameliorate hepatic steatosis by inhibition of the hepatokine fetuin-A
    Tae Woo Jung
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Republic of Korea
    Biochem Pharmacol 86:960-9. 2013
    ..Inhibition of palmitate-induced fetuin-A by salsalate was mediated by AMPK-mediated reduction of NFκB activity, which was blocked by AMPK siRNA or an inhibitor of AMPK...
  98. pmc Snf1 is a regulator of lipid accumulation in Yarrowia lipolytica
    John Seip
    Biochemical Sciences and Engineering, Central Research and Development, E I duPont de Nemours and Company, Wilmington, Delaware, USA
    Appl Environ Microbiol 79:7360-70. 2013
    ..This work presents a new role for Snf1/AMP-activated protein kinase (AMPK) pathways in lipid accumulation in this oleaginous yeast.
  99. doi Peroxiredoxin 1 is involved in disassembly of flagella and cilia
    Fanghua Gong
    Laboratory for Cell Biology, The First Affiliated Hospital, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, China
    Biochem Biophys Res Commun 444:420-6. 2014
    ..cells, the phenotype of cilia lost can be reversed, and the expression levels of tumor suppressor genes LKB1 and p-AMPK were increased, and the activity of the oncogene Aurora A was inhibited compared with those in cells transfected ..
  100. pmc Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile
    Cristina Oliveras-Ferraros
    Metabolism and Cancer Group Translational Research Laboratory Catalan Institute of Oncology Girona ICO Girona Girona, Spain Molecular Oncology Girona Biomedical Research Institute IDIBGi Girona, Spain
    Cell Cycle 13:1132-44. 2014
    ..gt; 10 months) in the presence of graded, millimolar concentrations of the anti-diabetic biguanide metformin, an AMPK agonist/mTOR inhibitor that has been evaluated in multiple in vitro and in vivo cancer studies and is now being ..
  101. doi Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation
    Faiza Kalfalah
    Institute of Clinical Chemistry and Laboratory Diagnostics, Heinrich Heine University, Med Faculty, Dusseldorf, Germany
    Exp Gerontol 56:59-68. 2014
    ..This was associated with upregulation of AMP-dependent protein kinase (AMPK), increased mRNA levels of PPARγ-coactivator 1α (PGC1A) and decreased levels of NAD(+)-dependent deacetylase ..

Research Grants79

  1. Inderjit Singh; Fiscal Year: 2014
    ..The present proposal is planned to evaluate the role of AMP-activated protein kinase (AMPK), a phylogenetically conserved, intracellular energy sensor switch which helps regulate glucose and lipid ..
  2. REUBEN JAMES SHAW; Fiscal Year: 2015
    ..AMP- activated protein kinase (AMPK) is a master regulator of cellular and organismal metabolism which acts as sensor of cellular energy status and ..
  3. Katja A Lamia; Fiscal Year: 2016
    ..transcriptional regulators by virtue of their susceptibility to phosphorylation by AMP-activated protein kinase (AMPK) and their ability to modulate glucocorticoid receptor dependent transcription...
  4. Efficacy Of Metformin In The Methylnitrosourea-Induced Model Of ER
    Terisa Davis; Fiscal Year: 2013
    ..implications for cancer processes, including cellular energetic stress, activation of ATP-activated protein kinase (AMPK), and inhibition of mammalian target ofrapamycin (mTOR)...
  5. REUBEN JAMES SHAW; Fiscal Year: 2016
    ..for the ability of LKB1 to suppression tumorigenesis in a NSCLC xenograft model;2) genetically define the role of AMPKa1 or AMPKa2 and related family kinases in a genetic engineered mouse model of NSCLC;and 3) examine the therapeutic ..
  6. Bayar Thimmapaya; Fiscal Year: 2016
    ..data indicate that Med1 is phosphorylated by energy sensor, adenosine monophosphate (AMP)-activated protein kinase (AMPK)...
  7. Rong Tian; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): AMP-activated protein kinase (AMPK) is serine/threonine kinase that serves as an intracellular energy sensor and a key regulator of cell metabolism, growth and death, hence a promising drug target for ..
  8. ADSS1 inactivation as a promoter of tumor metabolism and lung carcinogenesis
    Christopher R Herzog; Fiscal Year: 2010
    ..LKB1 activates AMP-activated protein kinase (AMPK), which in turn inhibits tumor survival via signal transduction through numerous effector pathways...
  9. Nissim Hay; Fiscal Year: 2016
    ..Akt activates mTORC1, at least in part, via the increase in intracellular ATP and the inactivation of AMPK, which otherwise inhibits mTORC1 activity...
  10. Min Du; Fiscal Year: 2014
    ..Our preliminary studies in fetal SM indicate that maternal obesity (MO) reduced AMP-activated protein kinase (AMPK) activity, and altered fetal SM development by enhancing intramuscular adipogenesis and fibrogenesis, both of which ..
  11. GENETIC REGULATION OF ALCOHOL METABOLISM IN YEAST
    Elton T Young; Fiscal Year: 2013
    ..Snf1 is a homolog of the ubiquitous AMP-activated protein kinases (AMPKs) found in all multicellular organisms. AMPK functions as an intracellular energy sensor, re-directing metabolic activity to correspond to the availability and ..
  12. Adiponectin regulates nutrient transport in the placenta
    Theresa L Powell; Fiscal Year: 2009
    ..and expression of placental LPL, glucose and amino acid transporters by inhibition of AMP-activated protein kinase (AMPK) and inhibits insulin-stimulated placental System A mediated amino acid transport by decreasing tyrosine ..
  13. Gerald Warren Hart; Fiscal Year: 2014
    ..Another key sensor of the cell's energy state is the 5'-AMP-dependent protein kinase, AMPK. AMPK isoforms are O- GlcNAcylated and many key AMPK substrates of are also regulated by O-GlcNAc...
  14. Circadian Repressors Cry1 and Cry2 Modulate Nuclear Hormone Receptor Function
    Katja A Lamia; Fiscal Year: 2013
    ..transcriptional regulators by virtue of their susceptibility to phosphorylation by AMP-activated protein kinase (AMPK), which causes their proteasomal degradation...
  15. The role of ATM in glucose transport and insulin signaling in skeletal muscle
    Jonathan S Fisher; Fiscal Year: 2010
    ..There is also evidence that ATM is an activating kinase for the AMP-activated protein kinase (AMPK), a mediator of insulin-independent stimulation of glucose transport...
  16. The function and regulation of TBC1D1 in skeletal muscle metabolism.
    MELISSA ANNE CHAMBERS; Fiscal Year: 2011
    ..expressed in skeletal muscle and is responsive to insulin-, contraction-, and the AMP-activated protein kinase (AMPK) activator AICARstimulation...
  17. Regulation and Function of hVps34 in Insulin Signaling
    Jonathan M Backer; Fiscal Year: 2010
    ..presented that links hVps34 to two nutrient sensing systems in mammalian cells: the AMP-activated Protein Kinase (AMPK), which regulates the utilization of alternative energy sources under low-nutrient conditions, and p70 S6-kinase (..
  18. To identify the mechanism by which AMP-dependent kinase regulates gene expression
    MAX RYAN BANKO; Fiscal Year: 2010
    ..The AMP-activated protein kinase (AMPK) is activated by low energy levels and plays a crucial role in longevity in invertebrates...
  19. Shelley L Berger; Fiscal Year: 2016
    ..an unanticipated novel pathway in the nucleus, where LKB1, the Peutz=Jeager kinase, and its downstream target, AMPK, function as transcriptional coactivators for p53...
  20. Henrik G Dohlman; Fiscal Year: 2015
    ..Aim 2: Elucidate G protein regulation by AMPK kinases. Elm1 phosphorylates Gpa1, thereby promoting its ubiquitination...
  21. Martin C Schmidt; Fiscal Year: 2016
    ..The most commonly prescribed therapeutic drugs used for type 2 diabetes target the AMP-activated protein kinase (AMPK). Therefore, understanding how AMPK is normally regulated is of great significance to human health...
  22. Exercise Induced Biochemical and Anatomical Adaptations
    John O Holloszy; Fiscal Year: 2013
    ..We have also shown that activation of AMP-activated protein kinase (AMPK) has a similar effect...
  23. MARIAN B CARLSON; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The highly conserved SNF1/AMP-activated protein kinase (AMPK) is a central energy regulator in eukaryotes...
  24. Mechanism of Metformin Action in Normal and PCOS Theca Cells
    Jan M McAllister; Fiscal Year: 2012
    ..An examination of the classical metformin activated LKB1/ AMP-activated protein kinase (AMPK) signaling cascade, provided the novel findings that LKB1 phosphorylation, as well as AMPK activity are decreased ..
  25. Ching Shih Chen; Fiscal Year: 2015
    ..information regulator (Sirt)1 expression, activation of the intracellular fuel sensor AMP-activated protein kinase (AMPK), and endoplasmic reticulum (ER) stress, the interplay among which culminated in autophagic and apoptotic cell ..
  26. AMP-activated protein kinase in hypertrophied hearts
    Rong Tian; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): AMP-activated protein kinase (AMPK) functions to maintain cellular energy homeostasis...
  27. RICHARD JOSEPH PIETRAS; Fiscal Year: 2014
    ..At a cellular level, metformin stimulates AMP-activated protein kinase (AMPK)...
  28. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..Our preliminary data also showed that AMPK signalling pathway is blunted in TKO mice...
  29. Alexander A Soukas; Fiscal Year: 2014
    ..elegans, as it is in mammals, is partially genetically dependent upon AMP-activated protein kinase (AMPK) signaling. This indicates that C...
  30. Nihal Tumer; Fiscal Year: 2015
    ..signal transducer and activator of transcription protein 3 (STAT3) and the nutrient sensing AMP-activated kinase (AMPK)/acetyl CoA carboxylase (ACC) pathways...
  31. Mechanisms for the Effects of Hypothalamic PTP1B on Energy Balance
    KARYN JOANNE CATALANO; Fiscal Year: 2010
    ..leptin to suppress food intake, induce phosphorylation of key enzymes in the leptin pathway such as STATS and AMPK, and the ability of leptin to induce expression of important neuropeptides for energy regulation...
  32. Xiang Fang; Fiscal Year: 2015
    ..cause a redox-dependent activation of Ataxia Telangiectasia- Mutated (ATM) kinase, phosphorylates and alters AMPK activity in DM1...
  33. JESSICA JEAN HOWELL; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): AMP-dependent protein kinase (AMPK) is activated by energy deprivation and is a critical regulator of cellular energy balance...
  34. Aging, Inflammation and Exercise in Chronic Stroke
    Alice S Ryan; Fiscal Year: 2012
    ..systemic insulin sensitivity compared to stretch control in stroke patients by altering downstream signaling (AMPK, JNK, IRS1- Ser307, Akt and p-38 MAPK phosphorylation) and GS activity in hemiparetic and nonparetic leg skeletal ..
  35. Claire C Bastie; Fiscal Year: 2014
    ..Fyn as a novel element of the nutrient-sensor system that regulates cellular and whole body energy homeostasis via AMPK and its upstream kinase, LKB1. In our published work (Bastie et. al. 2007 Cell Metab...
  36. Jeffrey E Pessin; Fiscal Year: 2014
    ..We will also examine the interaction of these pathways with the LKB1/AMPK patiiway in mediating glucose uptake and GLUT4 translocation...
  37. NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITY
    Raymond F Novak; Fiscal Year: 2010
    ..translation and miRNA translation repression or degradation;3) To establish whether glucagon, through PKA, and/or AMPK signaling, regulates CYP2E1 gene transcription;and 4) To determine the mechanism by which glucagon, through PKA and/..
  38. Structure and mechanism of the AMP-activated protein kinase
    Lawrence Shapiro; Fiscal Year: 2010
    AMP-activated protein kinase (AMPK) coordinates metabolism with energy availability in eukaryotes by responding to changes in intracellular ATP and AMP levels...
  39. Claude A Piantadosi; Fiscal Year: 2016
    ..crisis, while a rescue pathway is delayed involving the adenosine monophosphate (AMP)-activated protein kinase (AMPK) and PGC-1[unreadable] co-activator...
  40. Interaction of Estrogen and AMPK in the Hypothalamus
    Jessica Healy; Fiscal Year: 2012
    ..NPY, AgRP, and POMC are also regulated by the cellular energy sensing enzyme AMP-activated protein kinase (AMPK), which is phosphorylated (pAMPK) by the enzyme liver kinase B1 (LKB1) and activated when a decrease in the AMP:ATP ..
  41. Rakesh C Kukreja; Fiscal Year: 2016
    ..PDE-5) protects T2D hearts through suppression of myocardial oxidative stress and inflammasome formation via the AMPK/Sirt1/PGC-1[unreadable] signal transduction network that leads to induction of mitochondrial antioxidant enzyme - ..
  42. Regulation of Serine/Threonine Kinases in Skeletal Muscle
    Laurie J Goodyear; Fiscal Year: 2012
    ..A novel protein, sucrose-non-fermenting protein kinase 1 /AMPK-related kinase (SNARK), has been identified as a putative signaling protein in skeletal muscle and has been ..
  43. BROOKE ELIZABETH CHRISTIAN; Fiscal Year: 2014
    ..DNA damage signaling, ATM is activated by ROS and inhibits mTORC1 via activation of AMP-activated protein kinase (AMPK)...
  44. Nitric oxide and mitochondrial biogenesis in sepsis
    Claude A Piantadosi; Fiscal Year: 2012
    ..biogenesis through the major co-activator, PGC-11 and the adenosine monophosphate (AMP)-activated protein kinase (AMPK)...
  45. Modulation of GABAB receptor signaling
    Stephen J Moss; Fiscal Year: 2010
    ..have illustrated that GABAB receptors are phosphorylated by intimately-associated AMP-dependent protein kinase (AMPK) a process that enhances their activity, together with the strength of neuronal inhibition...
  46. Kenneth R Hallows; Fiscal Year: 2015
    ..Recent work has established that the metabolic sensor AMP-activated protein kinase (AMPK) inhibits the activity of ENaC and other important epithelial transport proteins, which appears to provide a ..
  47. Mechanisms of Kinase-dependent Regulation of the V-ATPase in Kidney
    NURIA M PASTOR-SOLER; Fiscal Year: 2013
    ..In addition, activation of the metabolic sensor AMP-activated protein kinase (AMPK) prevents V- ATPase translocation in clear cells and ICs, and that both PKA and AMPK phosphorylate V-ATPase A and ..
  48. JAROSLAW WALDEMAR ZMIJEWSKI; Fiscal Year: 2015
    ..Recent studies from our laboratory and others demonstrate that activation of the AMP-activated protein kinase (AMPK) has potent anti-inflammatory effects in TLR2 or TLR4 stimulated neutrophils, macrophages, and other cell ..
  49. Stephen D Anton; Fiscal Year: 2014
    ..function (State 3 &4 respiration), (ii) increases in levels of PGC-1α, AMP-activated protein kinase (AMPK), and Sirtuins (i.e...
  50. Benjamin E Turk; Fiscal Year: 2016
    ..AMP-activated protein kinase (AMPK) is a conserved sensor of cellular energy status, acting as a critical node in signaling networks controlling ..
  51. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..attenuating endothelial nitric oxide synthase (eNOS) and 5'-adenosine monophosphate-activated protein kinase (AMPK), and enhances glucose disposal and glycogen storage by preventing desensitization of adrenergic receptor actions ..
  52. Regulation of LKB1 and AMPK Signaling by BRAF in Melanoma
    Bin Zheng; Fiscal Year: 2012
    ..found that oncogenic BRAF V600E suppresses the activities ofthe tumor suppressor LKBl and its downstream kinase AMPK through indirect phosphorylation on LKBl...
  53. Kun Liang Guan; Fiscal Year: 2016
    ..However, the molecular mechanism of TORC1 in autophagy regulation is unknown. The AMP activated protein kinase (AMPK) is a key cellular energy sensor and functions to maintain cellular energy homeostasis...
  54. Dongmin Liu; Fiscal Year: 2016
    ..promotes energy metabolism and insulin sensitivity and whether these effects are mediated via activation of AMPK??, a master regulator of cellular energy homeostasis and potential therapeutic target for T2D...
  55. Sterling C Johnson; Fiscal Year: 2014
    ..brain assessed in vivo with PET FDG and in situ with assays of key metabolic regulators PGC-1a, SIRT1, mTOR, and AMPK. Finally Aim 5 provides an integrative Aim examining associative convergence among the various markers in the study ..
  56. Intermediary Metabolism, Histone Acetylation, and Transcriptional Regulation
    Ales Vancura; Fiscal Year: 2013
    ..Since orthologs Snf1 in yeast cells and AMP-activated protein kinase (AMPK) in mammalian cells phosphorylate and inhibit ACC, the Aim 1 of this proposal addresses whether Snf1 and AMPK ..
  57. Structural biology of enzymes in fatty acid metabolism
    Liang Tong; Fiscal Year: 2012
    ..carboxylases (ACCs), pyruvate carboxylase (PC), carnitine acyltransferases, and AMP-activated protein kinase (AMPK) play crucial roles in the metabolism of fatty acids and/or carbohydrates, as well as other important cellular ..
  58. NANCIE MACIVER; Fiscal Year: 2014
    ..and co-stimulatory membrane protein CD28;that leptin activates the metabolic mediator AMP-activated protein kinase (AMPK) in lymphocytes;and that leptin is necessary for glucose uptake in activated cells...
  59. AMPK Endothelial Cell Dysfunction and the Metabolic Syndrome (PROGRAM PROJECT)
    Neil B Ruderman; Fiscal Year: 2013
    ..these abnormalities could be the result of dysregulation of the fuel-sensing enzyme AMP-activated protein kinase (AMPK)...
  60. Bingzhong Xue; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): AMP-activated protein kinase (AMPK) is an evolutionally conserved cellular energy sensor that regulates metabolic pathways in lipid, cholesterol and glucose metabolism...
  61. The AMP-activated protein kinase (AMPK) antagonizes inflammation through SIRT1
    Hang Shi; Fiscal Year: 2012
    ..Two signaling proteins that may mediate this process are the two nutrient sensors: AMPK-activated protein kinase (AMPK) and SIRT...
  62. Oxymax System with Teadmill for Quantifying Exercise in Mice
    Neil B Ruderman; Fiscal Year: 2012
    ..of exercise are very likely mediated, in great measure, by the fuel sensing enzyme AMP-activated protein kinase (AMPK)...
  63. Nutritional and Hormonal Control of the Phosphorylation Regulation of GPAT1
    JENNIFER FRAHM; Fiscal Year: 2009
    ..Furthermore, GPAT1 is phosphorylated by protein kinase CK2 and AMPK in vitro concomitant with an increase and decrease in GPAT1 activity, respectively...
  64. Aging, AMP Kinase and Skeletal Muscle Overload
    Scott Gordon; Fiscal Year: 2005
    ..decline with age, and we have strong data showing that the phosphorylation of 5'-AMP- activated protein kinase (AMPK; which suppresses protein translation and synthesis) is upregulated with age in a fast-twitch-specific manner in ..
  65. A novel model for studying fetal skeletal muscle development
    Min Du; Fiscal Year: 2009
    ..studies, we observed that maternal obesity and over-nutrition down-regulated AMP-activated protein kinase (AMPK) activity and insulin signaling, and promoted adipogenesis which should be associated with altered proliferation ..
  66. Physiology of Malonyl-CoA in Muscle during Exercise
    WILLIAM WINDER; Fiscal Year: 2006
    ..Upstream signaling proteins, AMP-activated protein kinase (AMPK) and AMP-activated protein kinase kinase (AMPKK) will be investigated...
  67. Roles and Regulation of Acetyl-CoA Carboxylase
    LEE WITTERS; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): The AMP-activated protein kinase (AMPK), a mammalian member of the AMPK/SNF1 protein kinase family, is a central regulator of many aspects of metabolism, including fatty acid and ..
  68. Exploiting AMPK to Slow Polycystic Kidney Disease
    Vinita Takiar; Fiscal Year: 2009
    ..Both of these targets lie downstream of and are antagonized by Adenosine Monophosphate-activated Protein Kinase (AMPK). Previous therapies have been targeted to address one or the other of these two processes...
  69. AMP-activated protein kinase management will improve oocyte cryopreservation
    Daniel Allen Rappolee; Fiscal Year: 2010
    ..b>AMPK regulates oocyte maturation during stress and regulates a transcription factor maintaining potency in 2-cell ..
  70. Mouse Model of Pancreatic Tumorigenesis with Dysregulation of mTOR
    Chongjuan Wei; Fiscal Year: 2009
    ..suppressor LKB1 has been shown to be a negative regulator of mTOR [mammalian target of rapamycin] signaling via AMPK activation of the tuberous sclerosis complex 2 (TSC2)...
  71. Role of neuropeptide Y-glucose inhibited (NPY-GI) neurons in cytokine-induced ano
    Vanessa H Routh; Fiscal Year: 2010
    ..This is mediated by AMP-activated protein kinase (AMPK)...
  72. Circadian Expression of Procolipase in the Liver: A Metabolic Signal
    Mark E Lowe; Fiscal Year: 2010
    ..procolipase-deficient, enterostatin-deficient, PLRP2-deficient and colipase transgene mice;2) to determine if AMPK-mediated pathways regulate the ectopic expression of procolipase and PLRP2 in response to metabolic stimuli and 3) ..
  73. Regulation of Mammalian Oocyte Maturation
    Stephen M Downs; Fiscal Year: 2010
    ..of cAMP produces 5-AMP, which is a potent activator of the stress response enzyme, AMP-activated protein kinase (AMPK)...
  74. The fuel sensing enzyme AMPK in the pathogenesis of prostate cancer
    Zhijun Luo; Fiscal Year: 2010
    b>AMPK is a fuel sensing enzyme that is activated by hormones, cytokines, exercise, and stresses that diminish cellular energy state (e.g., glucose deprivation)...