PRKAA1

Summary

Gene Symbol: PRKAA1
Description: protein kinase AMP-activated catalytic subunit alpha 1
Alias: AMPK, AMPKa1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase, catalytic alpha-1 chain, ACACA kinase, AMP -activate kinase alpha 1 subunit, AMP-activated protein kinase, catalytic, alpha-1, AMPK alpha 1, AMPK subunit alpha-1, HMGCR kinase, acetyl-CoA carboxylase kinase, hydroxymethylglutaryl-CoA reductase kinase, protein kinase, AMP-activated, alpha 1 catalytic subunit, tau-protein kinase PRKAA1
Species: human
Products:     PRKAA1

Top Publications

  1. Browne G, Proud C. A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. Mol Cell Biol. 2004;24:2986-97 pubmed
    ..eEF2 kinase is thus a target for mTOR signaling independently of previously known downstream components of the pathway. ..
  2. Sag D, Carling D, Stout R, Suttles J. Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol. 2008;181:8633-41 pubmed
    Herein, we demonstrate a role of AMP-activated protein kinase (AMPK) as a potent counterregulator of inflammatory signaling pathways in macrophages. Stimulation of macrophages with anti-inflammatory cytokines (i.e...
  3. Lizcano J, Göransson O, Toth R, Deak M, Morrice N, Boudeau J, et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 2004;23:833-43 pubmed
    ..the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase (AMPK)...
  4. Stapleton D, Mitchelhill K, Gao G, Widmer J, Michell B, Teh T, et al. Mammalian AMP-activated protein kinase subfamily. J Biol Chem. 1996;271:611-4 pubmed
    The mammalian 5'-AMP-activated protein kinase (AMPK) is related to a growing family of protein kinases in yeast and plants that are regulated by nutritional stress...
  5. Inoki K, Zhu T, Guan K. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003;115:577-90 pubmed
    ..Under energy starvation conditions, the AMP-activated protein kinase (AMPK) phosphorylates TSC2 and enhances its activity...
  6. Puissant A, Robert G, Fenouille N, Luciano F, Cassuto J, Raynaud S, et al. Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res. 2010;70:1042-52 pubmed publisher
    ..JNK inhibition or p62 knockdown prevented RSV-mediated autophagy and antileukemic effects. RSV also stimulated AMPK, thereby inhibiting the mTOR pathway...
  7. Shi Y, Hu Z, Wu C, Dai J, Li H, Dong J, et al. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nat Genet. 2011;43:1215-8 pubmed publisher
    ..1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9))...
  8. Shaw R, Kosmatka M, Bardeesy N, Hurley R, Witters L, Depinho R, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A. 2004;101:3329-35 pubmed
    AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status found in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP ratio...
  9. Gwinn D, Shackelford D, Egan D, Mihaylova M, Mery A, Vasquez D, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. 2008;30:214-26 pubmed publisher
    b>AMPK is a highly conserved sensor of cellular energy status that is activated under conditions of low intracellular ATP...

More Information

Publications118 found, 100 shown here

  1. Scholz R, Sidler C, Thali R, Winssinger N, Cheung P, Neumann D. Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. J Biol Chem. 2010;285:25753-66 pubmed publisher
    ..TAK1-TAB1 complex capable of directly activating full-length heterotrimeric mammalian AMP-activated protein kinase (AMPK) in vitro...
  2. Nagata D, Mogi M, Walsh K. AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress. J Biol Chem. 2003;278:31000-6 pubmed
    AMP-activated protein kinase (AMPK) is a stress-activated protein kinase that is regulated by hypoxia and other cellular stresses that result in diminished cellular ATP levels...
  3. Green M, Anderson K, Means A. Characterization of the CaMKK?-AMPK signaling complex. Cell Signal. 2011;23:2005-12 pubmed publisher
    The AMP-activated protein kinase (AMPK) is a critical regulator of energy homeostasis, and is a potential target for treatment of metabolic diseases as well as cancer...
  4. Hawley S, Pan D, Mustard K, Ross L, Bain J, Edelman A, et al. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2005;2:9-19 pubmed
    The AMP-activated protein kinase (AMPK) is a critical regulator of energy balance at both the cellular and whole-body levels. Two upstream kinases have been reported to activate AMPK in cell-free assays, i.e...
  5. Mihaylova M, Shaw R. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol. 2011;13:1016-23 pubmed publisher
    One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases...
  6. Hawley S, Davison M, Woods A, Davies S, Beri R, Carling D, et al. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem. 1996;271:27879-87 pubmed
    ..A., Selbert, M. A., Goldstein, E. G., Edelman, A. M., Carling, D., and Hardie, D. G. (1995) J. Biol. Chem. 270, 27186-27191). ..
  7. Herrero Martin G, Høyer Hansen M, García García C, Fumarola C, Farkas T, Lopez Rivas A, et al. TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells. EMBO J. 2009;28:677-85 pubmed publisher
    ..TRAIL-induced autophagy is mediated by the AMP-activated protein kinase (AMPK) that inhibits mammalian target of rapamycin complex 1, a potent inhibitor of autophagy...
  8. Voss M, Paterson J, Kelsall I, Martin Granados C, Hastie C, Peggie M, et al. Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. Cell Signal. 2011;23:114-24 pubmed publisher
    Activation of 5'-AMP-activated protein kinase (AMPK) is believed to be the mechanism by which the pharmaceuticals, metformin and phenformin, exert their beneficial effects for treatment of type 2 diabetes...
  9. Hallows K, Raghuram V, Kemp B, Witters L, Foskett J. Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J Clin Invest. 2000;105:1711-21 pubmed
    ..The alpha1 (catalytic) subunit of AMP-activated protein kinase (AMPK) was identified as a dominant and novel interacting protein...
  10. Kim Y, Liang H, Liu X, Lee J, Cho J, Cheong J, et al. AMPK? modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer. Cancer Res. 2012;72:2512-21 pubmed publisher
    ..Through this approach, we identified the central metabolic regulator AMP-activated protein kinase (AMPK)? as a potential functional target in Asian gastric cancer...
  11. Jones R, Plas D, Kubek S, Buzzai M, Mu J, Xu Y, et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell. 2005;18:283-93 pubmed
    ..The glucose-dependent checkpoint occurs at the G(1)/S boundary and is regulated by AMP-activated protein kinase (AMPK). This cell-cycle arrest occurs despite continued amino acid availability and active mTOR...
  12. Wang C, Yen J, Cheng Y, Lin C, Hsieh C, Gau R, et al. Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet-induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles. Food Nutr Res. 2017;61:1379861 pubmed publisher
    ..b>Abbreviations: Abcg5: ATP-binding cassette subfamily G member 5; ALT: alanine aminotransferase; AMPK: adenosine monophosphate-activated protein kinase; AST: aspartate aminotransferase; B/F: Bacteroidetes to ..
  13. Valero T. Mitochondrial biogenesis: pharmacological approaches. Curr Pharm Des. 2014;20:5507-9 pubmed
    ..as a compensatory adaptation to the energetic deficits in mitochondrial diseases are described (PGC- 1, Sirtuins, AMPK)...
  14. Engin A. Human Protein Kinases and Obesity. Adv Exp Med Biol. 2017;960:111-134 pubmed publisher
    ..Like adenosine monophosphate (AMP)-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR), N-terminal Per-ARNT-Sim (PAS) kinase are nutrient responsive protein ..
  15. Zhao Z, Barcus M, Kim J, Lum K, Mills C, Lei X. High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs. J Nutr. 2016;146:1625-33 pubmed publisher
    ..P70), and phosphorylated ribosomal protein S6 (P-S6); 88-105%], energy metabolism [AMP-activated protein kinase (AMPK); up to 2.8-fold], and selenoprotein glutathione peroxidase 3 (GPX3; 1.4-fold) and suppressed (P < 0...
  16. Park S, Sung Y, Jang S, Nho K, Choi G, Kim H. The Korean herbal medicine, Do In Seung Gi-Tang, attenuates atherosclerosis via AMPK in high-fat diet-induced ApoE(-/-) mice. BMC Complement Altern Med. 2016;16:352 pubmed publisher
    ..molecule-1 [VCAM-1], and E-selectin), fatty acid synthase (FAS), adenosine monophosphate-activated protein kinase (AMPK), and acetyl-coA carboxylase (ACC) in the aorta or liver tissues was measured by western blot analysis...
  17. Naowaboot J, Wannasiri S, Pannangpetch P. Vernonia cinerea water extract improves insulin resistance in high-fat diet-induced obese mice. Nutr Res. 2018;56:51-60 pubmed publisher
    ..mice by modulating both phosphatidylinositol-3-kinase (PI3K) and adenosine monophosphate-activated protein kinase (AMPK) pathways in liver, skeletal muscle, and adipose tissue...
  18. Nguyen P, GREENE E, Ishola P, Huff G, Donoghue A, Bottje W, et al. Chronic Mild Cold Conditioning Modulates the Expression of Hypothalamic Neuropeptide and Intermediary Metabolic-Related Genes and Improves Growth Performances in Young Chicks. PLoS ONE. 2015;10:e0142319 pubmed publisher
    ..Compared to the control condition, CMCC increased the mRNA abundance of AMPKα1/α2 and decreased mTOR gene expression (P<0.05), the master energy and nutrient sensors, respectively...
  19. Hsu J, Lin H, Hsu C, Chen B, Chen J. Aqueous Extract of Pepino (Solanum muriactum Ait) Leaves Ameliorate Lipid Accumulation and Oxidative Stress in Alcoholic Fatty Liver Disease. Nutrients. 2018;10: pubmed publisher
    ..effect of AEPL might be mediated via inducing hepatic levels of phospho-adenosine monophosphate-activated kinase (p-AMPK) and peroxisome proliferator-activated receptor (PPAR)-?, and reducing the expressions of hepatic lipogenic enzymes,..
  20. Choi S, Lim J, Kim M, Kim E, Kim Y, Choi B, et al. Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy. Metabolism. 2018;85:348-360 pubmed publisher
    ..Consistent up-regulation of phospho-Thr172 AMP-dependent kinase (AMPK), peroxisome proliferative-activated receptor ? (PPAR?), phospho-Thr473 Akt, phospho-Ser79..
  21. Luo L, Li J, Liu H, Jian X, Zou Q, Zhao Q, et al. Adiponectin Is Involved in Connective Tissue Growth Factor-Induced Proliferation, Migration and Overproduction of the Extracellular Matrix in Keloid Fibroblasts. Int J Mol Sci. 2017;18: pubmed publisher
    ..Phosphorylation of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3 kinase-protein kinase (PI3K-Akt) were examined ..
  22. Bao L, Hu L, Zhang Y, Wang Y. Hypolipidemic effects of flavonoids extracted from Lomatogonium rotatum. Exp Ther Med. 2016;11:1417-1424 pubmed
    ..a reverse transcription polymerase chain reaction; whereas FAS, adenosine monophosphate-activated protein kinase (AMPK) and threonine-172 phosphorylated AMPK protein levels were detected by western blotting...
  23. Chen H, Tsai T, Tsai Y, Liao J, Yen C, Chen C. Kefir peptides prevent high-fructose corn syrup-induced non-alcoholic fatty liver disease in a murine model by modulation of inflammation and the JAK2 signaling pathway. Nutr Diabetes. 2016;6:e237 pubmed publisher
    ..In addition, kefir peptides markedly increased phosphorylation of AMPK to downregulate its targeted enzymes, ACC (acetyl-CoA carboxylase) and SREBP-1c (sterol regulatory element-binding ..
  24. Krakauer T. Inflammasome, mTORC1 activation, and metabolic derangement contribute to the susceptibility of diabetics to infections. Med Hypotheses. 2015;85:997-1001 pubmed publisher
    ..switches cell metabolism from oxidative phosphorylation to glycolysis and deactivates AMP-activated protein kinase (AMPK), a critical sensor of nutrient and cellular energy, leading to mTORC1 activation...
  25. Liu X, Liu F, Deng C, Zhang M, Yang M, Xiao D, et al. Left ventricular deformation associated with cardiomyocyte Ca(2+) transients delay in early stage of low-dose of STZ and high-fat diet induced type 2 diabetic rats. BMC Cardiovasc Disord. 2016;16:41 pubmed publisher
    ..blot analysis showed that in 6-week T2DM rats, myocardial p-PLB expression was elevated, whereas p-CaMKII, p-AMPK and Sirt1 were significantly down-regulated (P < 0.05)...
  26. Yuan J, Zhang Y, Yan F, Zheng X. Association of PRKAA1 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population. Braz J Infect Dis. 2016;20:564-568 pubmed publisher
    ..However, the role of the polymorphisms of PRKAA1 gene in immune-response to infectious organisms remains unknown...
  27. Chen Q, Xie B, Zhu S, Rong P, Sheng Y, Ducommun S, et al. A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice. Diabetologia. 2017;60:336-345 pubmed publisher
    ..Tbc1d1 Ser231Ala-knockin mutation or harbouring skeletal muscle-specific Ampkα1/α2 (also known as Prkaa1/2) double-knockout mutations in response to an AMPK-activating agent, 5-aminoimidazole-4-carboxamide-1-β-D-..
  28. Mukherjee S, Chattopadhyay M, Bhattacharya S, Dasgupta S, Hussain S, Bharadwaj S, et al. A Small Insulinomimetic Molecule Also Improves Insulin Sensitivity in Diabetic Mice. PLoS ONE. 2017;12:e0169809 pubmed publisher
    ..production of adiponectin in db/db mice due to dmp effected lowering of circulatory TG and FFA levels, activates AMPK in skeletal muscle and this stimulates mitochondrial biogenesis and bioenergetics...
  29. Kim S, Kim G, Han D, Lee M, Kim I, Kim B, et al. Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition. Autophagy. 2017;13:1767-1781 pubmed publisher
    ..of autophagy and inflammasomes, primary mouse hepatocytes, human hepatoma cells, mouse embryonic fibroblasts with Ampk or Tsc2 knockout, and human or primary mouse macrophages were treated with ezetimibe and palmitate...
  30. Yang Z, Wu F, He Y, Zhang Q, Zhang Y, Zhou G, et al. A novel PTP1B inhibitor extracted from Ganoderma lucidum ameliorates insulin resistance by regulating IRS1-GLUT4 cascades in the insulin signaling pathway. Food Funct. 2018;9:397-406 pubmed publisher
    ..Finally, FYGL increased the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and consequently up-regulated the expression of glucose transporter type 4 (GLUT4), promoting GLUT4 transportation ..
  31. Liu P, Feng T, Zuo X, Wang X, Luo J, Li N, et al. A novel SIRT1 activator E6155 improves insulin sensitivity in type 2 diabetic KKAy mice. Biochem Biophys Res Commun. 2018;498:633-639 pubmed publisher
    ..we observed that the antidiabetic effects of E6155 were involved in SIRT1 dependent activation of LKB1/AMPK and IRS1/AKT pathways...
  32. Chang M, Ho F, Wang J, Kang H, Chang Y, Ye Z, et al. AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-beta-activated kinase 1-p38 mitogen-activated protein kinase signaling pathway. Biochem Pharmacol. 2010;80:1210-20 pubmed publisher
    AMP-activated protein kinase (AMPK), a critical signaling molecule for regulating energy homeostasis, might bi-directionally regulate inflammation, and its action mechanism leading to inflammation is not fully understood...
  33. Tsai C, Tsai H, Huang H, Hung C, Hsu C, Fong Y, et al. Resistin promotes tumor metastasis by down-regulation of miR-519d through the AMPK/p38 signaling pathway in human chondrosarcoma cells. Oncotarget. 2015;6:258-70 pubmed
    ..Additionally, AMP-activated protein kinase (AMPK) and p38 inhibitors or siRNAs reduced the resistin-increased cell migration and miR-519d suppression, and ..
  34. Huna A, Salmina K, Erenpreisa J, Vazquez Martin A, Krigerts J, Inashkina I, et al. Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. Cell Cycle. 2015;14:2969-84 pubmed publisher
    ..Instead, ETO-induced OCT4A was concomitant with activation of AMPK, a key component of metabolic stress and autophagy regulation...
  35. Xing Y, Liu Y, Liu X, Wang S, Li P, Lin X, et al. Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome. Exp Ther Med. 2017;13:3567-3573 pubmed publisher
    ..target of rapamycin (mTOR), tumor suppressor p53 (p53), adenosine monophosphate-activated protein kinase (AMPK), sestrin2 and tuberous sclerosis protein 1/2 were evaluated using quantitative polymerase chain reaction and ..
  36. El aarag S, Mahmoud A, Hashem M, Abd Elkader H, Hemeida A, Elhefnawi M. In silico identification of potential key regulatory factors in smoking-induced lung cancer. BMC Med Genomics. 2017;10:40 pubmed publisher
    ..potentially related to lung cancer (MAPK1, IGF1R, RPS6KA1, ATR, MAPK14, MAPK3, MAPK4, MAPK8, PRKCZ, and INSR, and PRKAA1). However, PRKAA1 is reported here for the first time...
  37. Cuyàs E, Fernández Arroyo S, Verdura S, García R, Stursa J, Werner L, et al. Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism. Oncogene. 2017;: pubmed publisher
    ..analog of metformin (norMitoMet) in experimental pairs of wild-type and AMP-activated protein kinase (AMPK)-, serine hydroxymethyltransferase 2 (SHMT2)- and mCI-null cells, we provide evidence that metformin increases the ..
  38. Boyle K, Patinkin Z, Shapiro A, Bader C, Vanderlinden L, Kechris K, et al. Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants. Mol Metab. 2017;6:1503-1516 pubmed publisher
    ..In infant MSCs undergoing myogenesis in vitro, we measured cellular lipid metabolism and AMPK activity, AMPK activation in response to cellular nutrient stress, and MSC DNA methylation and mRNA content of ..
  39. Fang X, Shen F, Lechauve C, Xu P, Zhao G, Itkow J, et al. miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia. Haematologica. 2018;103:406-416 pubmed publisher
    ..erythroblasts exhibit abnormally increased Cab39 protein, which activates LKB1 and its downstream AMPK/mTOR effector pathway...
  40. Liu Z, Chen J, Huang H, Kuznicki M, Zheng S, Sun W, et al. The protective effect of trimetazidine on myocardial ischemia/reperfusion injury through activating AMPK and ERK signaling pathway. Metabolism. 2016;65:122-30 pubmed publisher
    ..AMP-activated protein kinase (AMPK) is an energy sensor that controls ATP supply from substrate metabolism and protects heart from energy stress...
  41. Budiono B, See Hoe L, Brunt A, Peart J, Headrick J, Haseler L. Coupling of myocardial stress resistance and signalling to voluntary activity and inactivity. Acta Physiol (Oxf). 2016;218:112-22 pubmed publisher
    ..ischaemic tolerance to physical activity and inactivity, and whether this involves modulation of survival (AKT, AMPK, ERK1/2, HSP27, EGFR) and injury (GSK3?) proteins implicated in ischaemic preconditioning and calorie restriction...
  42. Kim S, Tang T, Abbott M, Viscarra J, Wang Y, Sul H. AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose Tissue. Mol Cell Biol. 2016;36:1961-76 pubmed publisher
    The role of AMP-activated protein kinase (AMPK) in promoting fatty acid (FA) oxidation in various tissues, such as liver and muscle, has been well understood...
  43. Wu Y, Li Q, Li P, Liu B. GSK621 activates AMPK signaling to inhibit LPS-induced TNF? production. Biochem Biophys Res Commun. 2016;480:289-295 pubmed publisher
    ..We here tested the potential effect of GSK621, a novel AMP-activated protein kinase (AMPK) activator, against the process. In RAW264...
  44. Oladimeji P, Lin W, Brewer C, Chen T. Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase. Sci Rep. 2017;7:46751 pubmed publisher
    ..We demonstrated that AMP-activated protein kinase (AMPK) modulates PXR transcriptional activity and that pharmacologically manipulated AMPK activation exhibits an inverse ..
  45. Arha D, Ramakrishna E, Gupta A, Rai A, Sharma A, Ahmad I, et al. Isoalantolactone derivative promotes glucose utilization in skeletal muscle cells and increases energy expenditure in db/db mice via activating AMPK-dependent signaling. Mol Cell Endocrinol. 2018;460:134-151 pubmed publisher
    Augmenting glucose utilization and energy expenditure in skeletal muscle via AMP-activated protein kinase (AMPK) is an imperative mechanism for the management of type 2 diabetes...
  46. Feng Y, Zhang Y, Xiao H. AMPK and cardiac remodelling. Sci China Life Sci. 2018;61:14-23 pubmed publisher
    ..AMP-activated protein kinase (AMPK) is known as an energy sensor and a regulator of cardiac metabolism under normal and ischaemic conditions...
  47. Iwaoka R, Kataoka K. Glucose regulates MafA transcription factor abundance and insulin gene expression by inhibiting AMP-activated protein kinase in pancreatic β-cells. J Biol Chem. 2018;293:3524-3534 pubmed publisher
    ..Moreover, AMP-activated protein kinase (AMPK), a regulator of cellular energy homeostasis, is inhibited by high glucose, and this inhibition is essential for ..
  48. Schuster S, Penke M, Gorski T, Gebhardt R, Weiss T, Kiess W, et al. FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells. Biochem Biophys Res Commun. 2015;458:334-40 pubmed publisher
    ..There is evidence that AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) become dysregulated during the development of hepatocellular carcinoma (..
  49. Bhardwaj A, Ganesan N, Tachibana K, Rajapakshe K, Albarracin C, Gunaratne P, et al. Annexin A1 Preferentially Predicts Poor Prognosis of Basal-Like Breast Cancer Patients by Activating mTOR-S6 Signaling. PLoS ONE. 2015;10:e0127678 pubmed publisher
    ..Stable annexin A1 knockdown in TNBC cell lines suppressed the mTOR-S6 pathway likely through activation of AMPK but had no impact on the MAPK, c-Met, and EGFR pathways...
  50. Murata Y, Uehara Y, Hosoi Y. Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6. Biochem Biophys Res Commun. 2015;468:684-90 pubmed publisher
    ..Both AMP-activated protein kinase (AMPK) and Akt were activated under nutrient starvation conditions in all the three cell lines...
  51. Li Y, Han B, Li F, Yu J, Dong Z, Niu G, et al. High Glucose Induces Down-Regulated GRIM-19 Expression to Activate STAT3 Signaling and Promote Cell Proliferation in Cell Culture. PLoS ONE. 2016;11:e0153659 pubmed publisher
    ..cells, 2) whether GRIM-19/STAT3 signaling pathway plays a role in HG induced biological effects, especially whether AMPK activity could be involved...
  52. Tan Y, Wong T, Lin S, Leung L. Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells. Mol Cell Biochem. 2017;424:163-172 pubmed publisher
    ..previously illustrated that apigenin and luteolin could attenuate the nuclear translocation of SREBP-2 through an AMPK-dependent pathway...
  53. Kang S, Zhang Z, Liu X, Manfredsson F, He L, Iuvone P, et al. α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation. Proc Natl Acad Sci U S A. 2017;114:1183-1188 pubmed publisher
    ..manner and sequesters it in Lewy bodies, leading to dopaminergic cell death via AMP-activated protein kinase (AMPK) hyperactivation...
  54. Chow Y, Iwata Y, Sato F. Dihydrosanguinarine Enhances Glucose Uptake in Mouse 3T3-L1 Cells. ACS Omega. 2017;2:6916-6925 pubmed publisher
    ..and insulin sensitivity are mediated by suppressing adenosine monophosphate-activated protein kinase (AMPK) alpha, upregulating the expression of PPAR? and its target genes (particularly Glut-4 and adiponectin..
  55. Sujobert P, Poulain L, Paubelle E, Zylbersztejn F, Grenier A, Lambert M, et al. Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia. Cell Rep. 2015;11:1446-57 pubmed publisher
    b>AMPK is a master regulator of cellular metabolism that exerts either oncogenic or tumor suppressor activity depending on context...
  56. Lin C, Huang W, Li H, Huang C, Hsieh S, Lai C, et al. Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells. Chem Biol Interact. 2015;240:12-21 pubmed publisher
    ..In addition, HRW also stimulated AMP-activated protein kinase (AMPK) in a sirtuin 1 (Sirt1)-dependent pathway, which upregulates forkhead box protein O3a (FoxO3a) downstream ..
  57. Martínez Zamora A, Meseguer S, Esteve J, Villarroya M, Aguado C, Enríquez J, et al. Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier. PLoS ONE. 2015;10:e0144273 pubmed publisher
    ..Our data indicate that stable silencing of GTPBP3 triggers an AMPK-dependent retrograde signaling pathway that down-regulates the expression of the NDUFAF3 and NDUFAF4 Complex I ..
  58. Kim S, Lee K, Kim J, Choi H. Estrogenic compound attenuates angiotensin II-induced vascular smooth muscle cell proliferation through interaction between LKB1 and estrogen receptor ?. J Pharmacol Sci. 2016;132:78-85 pubmed publisher
    ..cardiovascular disease is higher for males than females, and estradiol (E2) induces AMP-activated protein kinase (AMPK) activation, which is known to regulate proliferation of VSMC...
  59. Ouyang Z, Wang X, Meng Q, Feng L, Sun Y, Wu X, et al. Suppression of adenosine monophosphate-activated protein kinase selectively triggers apoptosis in activated T cells and ameliorates immune diseases. Biochem Biophys Res Commun. 2017;487:223-229 pubmed publisher
    ..Altogether, these results suggest that AMPK inhibition by glibenclamide can regulate the survival and death of T lymphocytes and be beneficial for the ..
  60. Li R, Luo X, Zhu Y, Zhao L, Li L, Peng Q, et al. ATM signals to AMPK to promote autophagy and positively regulate DNA damage in response to cadmium-induced ROS in mouse spermatocytes. Environ Pollut. 2017;231:1560-1568 pubmed publisher
    ..DNA damage, autophagy and the expression of the molecular signaling pathway ATM/AMP-activated protein kinase (AMPK)/mTOR were determined...
  61. Lu J, Cheng B, Meng Z, Fang B, Li T, Sun M, et al. Alliin attenuates 1, 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway. Life Sci. 2018;195:19-24 pubmed publisher
    ..we showed that alliin attenuated lipogenesis induced by 1,3-DCP and that the reduction was due to activation of the AMPK pathway...
  62. Etwebi Z, Landesberg G, Preston K, Eguchi S, Scalia R. Mechanistic Role of the Calcium-Dependent Protease Calpain in the Endothelial Dysfunction Induced by MPO (Myeloperoxidase). Hypertension. 2018;71:761-770 pubmed publisher
    ..MPO also reduced Thr172 AMPK (AMP-activated protein kinase) and Ser1177 eNOS (endothelial nitric oxide synthase) phosphorylation via ..
  63. Guo S, Yao Q, Ke Z, Chen H, Wu J, Liu C. Resveratrol attenuates high glucose-induced oxidative stress and cardiomyocyte apoptosis through AMPK. Mol Cell Endocrinol. 2015;412:85-94 pubmed publisher
    ..activity and its subunits expression, antioxidant enzymes activities, as well as the potential regulatory molecules AMPK, Akt and GSK-3β were assessed in cardiac cells...
  64. Williams E, Rogers S, Zhang X, Azhar G, Wei J. Elevated oxygen consumption rate in response to acute low-glucose stress: Metformin restores rate to normal level. Exp Gerontol. 2015;70:157-62 pubmed publisher
    ..This effect appears, in part, to involve activation of the 5' AMP-activated protein kinase (AMPK).
  65. Mangels N, Awwad K, Wettenmann A, Dos Santos L, Frömel T, Fleming I. The soluble epoxide hydrolase determines cholesterol homeostasis by regulating AMPK and SREBP activity. Prostaglandins Other Lipid Mediat. 2016;125:30-9 pubmed publisher
    ..The effect was attributed to the AMPK-activated protein kinase (AMPK) which was activated in the absence of sEH...
  66. Zhang P, Liu X, Huang G, Bai C, Zhang Z, Li H. Barbaloin pretreatment attenuates myocardial ischemia-reperfusion injury via activation of AMPK. Biochem Biophys Res Commun. 2017;490:1215-1220 pubmed publisher
    ..Furthermore, BAR pretreatment activated adenosine monophosphate-activated protein kinase (AMPK) signaling in MI/R hearts...
  67. Hao B, Xiao Y, Song F, Long X, Huang J, Tian M, et al. Metformin-induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16. Int J Mol Med. 2018;41:1365-1376 pubmed publisher
    ..antimigratory effects of metformin have been attributed to 5' adenosine monophosphate-activated protein kinase (AMPK) activation...
  68. Lim R, Barker G, Lappas M. Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators. Placenta. 2015;36:454-62 pubmed publisher
    In non-gestational tissues, the activation of adenosine monophosphate (AMP)-activated kinase (AMPK) is associated with potent anti-inflammatory actions...
  69. Gabriel B, Hamilton D, Tremblay A, Wackerhage H. The Hippo signal transduction network for exercise physiologists. J Appl Physiol (1985). 2016;120:1105-17 pubmed publisher
    ..include mechanotransduction, the AKT-mTORC1 network, the SMAD transcription factors, hypoxia, glucose homeostasis, AMPK, adrenaline/epinephrine and angiotensin II through G protein-coupled receptors, and IL-6...
  70. Jeon S. Regulation and function of AMPK in physiology and diseases. Exp Mol Med. 2016;48:e245 pubmed publisher
    5'-adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase that was originally identified as the key player in maintaining cellular energy homeostasis...
  71. Zhou D, Su Y, Jiang F, Xia J, Wu H, Chang Z, et al. CpG oligodeoxynucleotide preconditioning improves cardiac function after myocardial infarction via modulation of energy metabolism and angiogenesis. J Cell Physiol. 2017;: pubmed publisher
    ..conditions by enhancing stress tolerance through TLR9-mediated inhibition of the SERCA2/ATP and activation of AMPK pathways...
  72. Schuetz T, Becker S, Mang A, Toma A, Buzug T. A computational multiscale model of glioblastoma growth: regulation of cell migration and proliferation via microRNA-451, LKB1 and AMPK. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:6620-3 pubmed publisher
    ..The network is based on recently published work on the interaction of microRNA-451, LKB1 and AMPK in the regulation of glioblastoma cell migration and proliferation...
  73. Püschel F, Muñoz Pinedo C. In the Hunger Games, the Winner Takes Everything. Trends Biochem Sci. 2017;42:763-764 pubmed publisher
    ..AMP-activated protein kinase (AMPK) activation in the loser cells triggers their engulfment and elimination by winner cells, which endure starvation.
  74. Li M, Verdijk L, Sakamoto K, Ely B, van Loon L, Musi N. Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise. Mech Ageing Dev. 2012;133:655-64 pubmed publisher
    AMP-activated protein kinase (AMPK) is a key energy-sensitive enzyme that controls numerous metabolic and cellular processes...
  75. Amare A, Schubert K, Klingler Hoffmann M, Cohen Woods S, Baune B. The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies. Transl Psychiatry. 2017;7:e1007 pubmed publisher
    ..A pathway analysis of these genes revealed significant pathways: corticotrophin-releasing hormone signaling, AMPK signaling, cAMP-mediated or G-protein coupled receptor signaling, axonal guidance signaling, serotonin or dopamine ..
  76. Huang J, Liu K, Zhu S, Xie M, Kang R, Cao L, et al. AMPK regulates immunometabolism in sepsis. Brain Behav Immun. 2018;72:89-100 pubmed publisher
    ..Here, we show that AMP-activated protein kinase (AMPK) is a negative regulator of bioenergetic reprogramming in immune cells and suppresses sepsis development in vivo...
  77. Cheng F, He M, Jung J, Lu C, Gao S. Suppression of Kaposi's Sarcoma-Associated Herpesvirus Infection and Replication by 5'-AMP-Activated Protein Kinase. J Virol. 2016;90:6515-6525 pubmed publisher
    ..The 5'-AMP-activated protein kinase (AMPK) is a cellular energy sensor regulating metabolic homeostasis...
  78. Wang D, Liu X, Liu Y, Li S, Wang C. The Effects of Cardiotrophin-1 on Early Synaptic Mitochondrial Dysfunction and Synaptic Pathology in APPswe/PS1dE9 Mice. J Alzheimers Dis. 2017;59:1255-1267 pubmed publisher
    ..Moreover, CT-1 upregulated the expression of AMPAR and increased AMP-activated protein kinase (AMPK) activity in the hippocampus of APPswe/PS1dE9 transgenic mice...
  79. Zaha V, Young L. AMP-activated protein kinase regulation and biological actions in the heart. Circ Res. 2012;111:800-14 pubmed publisher
    AMP-activated protein kinase (AMPK) is a stress-activated kinase that functions as a cellular fuel gauge and master metabolic regulator...
  80. Zhao L, Cui L, Jiang X, Zhang J, Zhu M, Jia J, et al. Extracellular pH regulates autophagy via the AMPK-ULK1 pathway in rat cardiomyocytes. FEBS Lett. 2016;590:3202-12 pubmed publisher
    ..We also find that adenosine monophosphate-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR) and Unc-51-like kinase 1 (ULK1) are very sensitive to pHe changes...
  81. Cao C, Gao T, Cheng M, Xi F, Zhao C, Yu W. Mild hypothermia ameliorates muscle wasting in septic rats associated with hypothalamic AMPK-induced autophagy and neuropeptides. Biochem Biophys Res Commun. 2017;490:882-888 pubmed publisher
    ..that mild hypothermia could ameliorate muscle wasting during sepsis and whether it was associated with hypothalamus AMPK-induced autophagy and neuropeptides...
  82. Burmeister M, Brown J, Ayala J, Stoffers D, Sandoval D, Seeley R, et al. The glucagon-like peptide-1 receptor in the ventromedial hypothalamus reduces short-term food intake in male mice by regulating nutrient sensor activity. Am J Physiol Endocrinol Metab. 2017;313:E651-E662 pubmed publisher
    ..of food intake by GLP-1R agonists (GLP-1RA) in this region is dependent on AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR)...
  83. He C, Li H, Viollet B, Zou M, Xie Z. AMPK Suppresses Vascular Inflammation In Vivo by Inhibiting Signal Transducer and Activator of Transcription-1. Diabetes. 2015;64:4285-97 pubmed publisher
    Activation of AMPK suppresses inflammation, but the underlying mechanisms remain poorly understood. This study was designed to characterize the molecular mechanisms by which AMPK suppresses vascular inflammation...
  84. Wang Y, Kuramitsu Y, Baron B, Kitagawa T, Tokuda K, Akada J, et al. CGK733-induced LC3 II formation is positively associated with the expression of cyclin-dependent kinase inhibitor p21Waf1/Cip1 through modulation of the AMPK and PERK/CHOP signaling pathways. Oncotarget. 2015;6:39692-701 pubmed publisher
    ..Treatment with CGK733 activated the AMP-activated protein kinase (AMPK) and protein kinase RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein (PERK/..
  85. Gonçalves C, Freitas M, Fortunato R, Miranda Alves L, Carvalho D, Ferreira A. Rutin Scavenges Reactive Oxygen Species, Inactivates 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK) and Increases NIS expression in thyroid PCCL3 Cells. Thyroid. 2017;: pubmed publisher
    ..We have previously shown that the flavonoid rutin increases thyroid radioiodide uptake in vivo, in rats. Herein, we aimed at studying the mechanisms involved in the stimulatory effect of rutin on iodide uptake...
  86. Bolnick A, Abdulhasan M, Kilburn B, Xie Y, Howard M, Andresen P, et al. Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress. J Assist Reprod Genet. 2017;34:1609-1617 pubmed publisher
    This study tests whether metformin or diet supplement BR-DIM-induced AMP-activated protein kinase (AMPK) mediated effects on development are more pronounced in blastocysts or 2-cell mouse embryos...
  87. Decara J, Rivera P, Arrabal S, Vargas A, Serrano A, Pavon F, et al. Cooperative role of the GLP-1 receptor and ?3-adrenergic-mediated signaling on fat mass reduction through the down-regulation of PKA/AKT/AMPK signaling in the adipose tissue and muscle of rats. Acta Physiol (Oxf). 2017;: pubmed publisher
  88. Tran M, Lee S, Shin D, Wang L. Loss of miR-141/200c ameliorates hepatic steatosis and inflammation by reprogramming multiple signaling pathways in NASH. JCI Insight. 2017;2: pubmed publisher
    ..In addition, elevated phosphorylated AMPK (p-AMPK), p-AKT, and p-GSK3? and diminished TLR4 and p-mTOR/p-4EBP1 proteins were observed...
  89. Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon J, et al. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem. 2010;285:9100-13 pubmed publisher
    ..anti-aging pathways via the activation of several metabolic sensors, including the AMP-activated protein kinase (AMPK)...
  90. Vazquez Martin A, Oliveras Ferraros C, Cufí S, Menendez J. Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus. Cell Cycle. 2011;10:1295-302 pubmed
    AMP-activated protein kinase (AMPK) is being primarily studied as a central metabolic stress sensor, which regulates cell survival and growth-related metabolic pathways to preserve intracellular ATP levels in response to energy ..
  91. Zhong W, Xie Y, Abdallah M, Awonuga A, Slater J, Sipahi L, et al. Cellular stress causes reversible, PRKAA1/2-, and proteasome-dependent ID2 protein loss in trophoblast stem cells. Reproduction. 2010;140:921-30 pubmed publisher
    ..In this study, we demonstrate that AMP-activated protein kinase (PRKAA1/2, aka AMPK) mediates the stress-induced proteasome-dependent loss of ID2 at high stress levels...
  92. Boutchueng Djidjou M, Collard Simard G, Fortier S, Hébert S, Kelly I, Landry C, et al. The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network. Mol Cell Proteomics. 2015;14:1079-92 pubmed publisher
    ..The IR interactome (IRGEN) connects ATIC to AMPK within the Golgi/endosome protein network (GEN)...