PRG4

Summary

Gene Symbol: PRG4
Description: proteoglycan 4
Alias: CACP, HAPO, JCAP, MSF, SZP, proteoglycan 4, articular superficial zone protein, hemangiopoietin, lubricin, megakaryocyte stimulating factor, superficial zone proteoglycan
Species: human
Products:     PRG4

Top Publications

  1. Flannery C, Hughes C, Schumacher B, Tudor D, Aydelotte M, Kuettner K, et al. Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism. Biochem Biophys Res Commun. 1999;254:535-41 pubmed
    ..that cartilage SZP is homologous with a glycoprotein first described as the precursor protein of a megakaryocyte stimulating factor (MSF)...
  2. Rhee D, Marcelino J, Baker M, Gong Y, Smits P, Lefebvre V, et al. The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest. 2005;115:622-31 pubmed
    ..Loss-of-function mutations in lubricin (a secreted glycoprotein encoded by the gene PRG4) cause the human autosomal recessive disorder camptodactyly-..
  3. Elsaid K, Fleming B, Oksendahl H, Machan J, Fadale P, Hulstyn M, et al. Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury. Arthritis Rheum. 2008;58:1707-15 pubmed publisher
    To study the effect of anterior cruciate ligament (ACL) injury on lubricin concentrations in synovial fluid (SF) and its correlation with time postinjury, inflammatory cytokines, lubricin-degrading enzymes, and SF proteoglycan content...
  4. Estrella R, Whitelock J, Packer N, Karlsson N. The glycosylation of human synovial lubricin: implications for its role in inflammation. Biochem J. 2010;429:359-67 pubmed publisher
    ..It was found that the most abundant protein in all of the samples was the mucin-like protein lubricin. Further characterization of lubricin from the different patients by LC (liquid chromatography)-MS of released ..
  5. Jin C, Ekwall A, Bylund J, Björkman L, Estrella R, Whitelock J, et al. Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity. J Biol Chem. 2012;287:35922-33 pubmed publisher
    Lubricin (or proteoglycan 4 (PRG4)) is an abundant mucin-like glycoprotein in synovial fluid (SF) and a major component responsible for joint lubrication...
  6. Jay G, Tantravahi U, Britt D, Barrach H, Cha C. Homology of lubricin and superficial zone protein (SZP): products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fibroblasts and articular chondrocytes localized to chromosome 1q25. J Orthop Res. 2001;19:677-87 pubmed
    We have previously identified megakaryocyte stimulating factor (MSF) gene expression by synovial fibroblasts as the origin of lubricin in the synovial cavity...
  7. Grad S, Lee C, Wimmer M, Alini M. Chondrocyte gene expression under applied surface motion. Biorheology. 2006;43:259-69 pubmed
    ..of chondrocytes cultured in 3D scaffolds, with a particular emphasis on different superficial zone protein (SZP)/lubricin transcripts...
  8. Zhang D, Johnson L, Hsu H, Spector M. Cartilaginous deposits in subchondral bone in regions of exposed bone in osteoarthritis of the human knee: histomorphometric study of PRG4 distribution in osteoarthritic cartilage. J Orthop Res. 2007;25:873-83 pubmed
    ..A specific aim was to determine the distribution of the joint lubrication molecule, lubricin/superficial zone protein [referred to by its gene, proteoglycan4 (PRG4)], in these cartilaginous deposits and in ..
  9. Gleghorn J, Jones A, Flannery C, Bonassar L. Boundary mode lubrication of articular cartilage by recombinant human lubricin. J Orthop Res. 2009;27:771-7 pubmed publisher
    Lubrication of cartilage involves a variety of physical and chemical factors, including lubricin, a synovial glycoprotein that has been shown to be a boundary lubricant...

More Information

Publications130 found, 100 shown here

  1. Kautzky Willer A, Harreiter J, Winhofer Stöckl Y, Bancher Todesca D, Berger A, Repa A, et al. [Gestational diabetes mellitus (Update 2019)]. Wien Klin Wochenschr. 2019;131:91-102 pubmed publisher
    ..Based on the results of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study and following the recent WHO recommendations, GDM is present if the fasting plasma glucose level exceeds 92..
  2. Levato R, Webb W, Otto I, Mensinga A, Zhang Y, van Rijen M, et al. The bio in the ink: cartilage regeneration with bioprintable hydrogels and articular cartilage-derived progenitor cells. Acta Biomater. 2017;61:41-53 pubmed publisher
    ..ACPCs had the lowest gene expression levels of hypertrophy marker collagen type X, and the highest expression of PRG4, a key factor in joint lubrication...
  3. Hyc A, Moskalewski S, Osiecka Iwan A. Influence of cartilage interstitial fluid on the mRNA levels of matrix proteins, cytokines, metalloproteases and their inhibitors in synovial membrane. Int J Mol Med. 2016;38:937-42 pubmed publisher
    ..CIF stimulated the expression of hyaluronan synthase (HAS)1 and 2, lubricin, collagen I, versican, aggrecan, matrix metalloproteinases (MMPs)2 and 3, tissue inhibitors of ..
  4. Kautzky Willer A, Harreiter J, Bancher Todesca D, Berger A, Repa A, Lechleitner M, et al. [Gestational diabetes mellitus]. Wien Klin Wochenschr. 2016;128 Suppl 2:S103-12 pubmed publisher
    ..Based on the results of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study GDM is defined, if fasting venous plasma glucose exceeds 92 mg/dl or 1 h 180 mg/dl or 2 h 153 mg/dl after ..
  5. Hod M, Kapur A, McIntyre H. Evidence in support of the International Association of Diabetes in Pregnancy study groups' criteria for diagnosing gestational diabetes mellitus worldwide in 2019. Am J Obstet Gynecol. 2019;: pubmed publisher
  6. Smith S, Melrose J. A Retrospective Analysis of the Cartilage Kunitz Protease Inhibitory Proteins Identifies These as Members of the Inter-α-Trypsin Inhibitor Superfamily with Potential Roles in the Protection of the Articulatory Surface. Int J Mol Sci. 2019;20: pubmed publisher
    ..Localisation of versican, lubricin and hyaluronan (HA) in the surface regions of articular cartilage represented probable binding sites for the ITI ..
  7. Lowe W, Bain J, Nodzenski M, Reisetter A, Muehlbauer M, Stevens R, et al. Maternal BMI and Glycemia Impact the Fetal Metabolome. Diabetes Care. 2017;40:902-910 pubmed publisher
    ..400 from each ancestry group) whose mothers participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and who had anthropometric measurements at birth...
  8. Solano Gallego L, Caprì A, Pennisi M, Caldin M, Furlanello T, Trotta M. Acute febrile illness is associated with Rickettsia spp infection in dogs. Parasit Vectors. 2015;8:216 pubmed publisher
    Rickettsia conorii is transmitted by Rhipicephalus sanguineus ticks and causes Mediterranean Spotted Fever (MSF) in humans. Although dogs are considered the natural host of the vector, the clinical and epidemiological significance of R...
  9. Portillo A, Santibáñez S, García Álvarez L, Palomar A, Oteo J. Rickettsioses in Europe. Microbes Infect. 2015;17:834-8 pubmed publisher
    ..Apart from Rickettsia conorii, the Mediterranean Spotted Fever (MSF) agent, other Rickettsia spp...
  10. Bjornstad P, Maahs D, Wadwa R, Pyle L, Rewers M, Eckel R, et al. Plasma triglycerides predict incident albuminuria and progression of coronary artery calcification in adults with type 1 diabetes: the Coronary Artery Calcification in Type 1 Diabetes Study. J Clin Lipidol. 2014;8:576-83 pubmed publisher
    ..Progression of coronary artery calcification (CACp), measured using electron beam computed tomography, was defined as a change in the square root transformed CAC ..
  11. Al Salem W, Herricks J, Hotez P. A review of visceral leishmaniasis during the conflict in South Sudan and the consequences for East African countries. Parasit Vectors. 2016;9:460 pubmed publisher
    ..In this review, literature published between 1955 and 2016 have been gathered from MSF, UNICEF, OCHA, UNHCR, PubMed and Google Scholar to analyse the correlation between conflict and human suffering ..
  12. Mendes L, Katagiri H, Tam W, Chai Y, Geris L, Roberts S, et al. Advancing osteochondral tissue engineering: bone morphogenetic protein, transforming growth factor, and fibroblast growth factor signaling drive ordered differentiation of periosteal cells resulting in stable cartilage and bone formation in vivo. Stem Cell Res Ther. 2018;9:42 pubmed publisher
    ..Osteochondral defects treated with TIs displayed glycosaminoglycan (GAG) production, type-II collagen, and lubricin expression...
  13. Urbanek M, Hayes M, Lee H, Freathy R, Lowe L, Ackerman C, et al. The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy. PLoS ONE. 2012;7:e32958 pubmed publisher
    ..between genetic variants in 31 inflammatory pathway genes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort, a large multiethnic multicenter study designed to address the impact of glycemia less than overt diabetes ..
  14. McDaniel J, Akula Suresh Babu R, Navarro M, LeBaron R. Transcriptional regulation of proteoglycan 4 by 17β-estradiol in immortalized baboon temporomandibular joint disc cells. Eur J Oral Sci. 2014;122:100-8 pubmed publisher
    ..b>Proteoglycan 4 (PRG4) is a secreted lubricating molecule required for maintaining low frictional levels within articular ..
  15. Wei Y, Yang H, Zhu W, Yang H, Li H, Yan J, et al. International Association of Diabetes and Pregnancy Study Group criteria is suitable for gestational diabetes mellitus diagnosis: further evidence from China. Chin Med J (Engl). 2014;127:3553-6 pubmed
    ..gestational diabetes mellitus (GDM) after extensive analyses of the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study. Unfortunately, there was no data from mainland of China in this study...
  16. Szychlinska M, Castrogiovanni P, Nsir H, Di Rosa M, Guglielmino C, Parenti R, et al. Engineered cartilage regeneration from adipose tissue derived-mesenchymal stem cells: A morphomolecular study on osteoblast, chondrocyte and apoptosis evaluation. Exp Cell Res. 2017;357:222-235 pubmed publisher
    ..some osteoblasts (Runt-related transcription factor 2 (RUNX2) and osteocalcin), chondrocytes (collagen I, II and lubricin) and apoptosis (caspase-3) biomarkers in undifferentiated AMSCs, differentiated AMSCs in chondrocytes cultured in ..
  17. Ohta Y, Okabe T, Larmour C, Di Rocco A, Maijenburg M, Phillips A, et al. Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg. Arthritis Rheumatol. 2015;67:2679-90 pubmed publisher
    ..Global gene expression data and other studies identified parathyroid hormone-related protein (PTHrP) and lubricin as possible downstream effectors and mediators of Erg action in articular chondrocytes...
  18. McLeod D, Warner J, Henman M, Cowley D, Gibbons K, McIntyre H. Associations of serum vitamin D concentrations with obstetric glucose metabolism in a subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort. Diabet Med. 2012;29:e199-204 pubmed publisher
    ..Intervention studies are required to determine causality and the role of vitamin D replacement in deficient individuals. ..
  19. Matsuzaki T, Alvarez Garcia O, Mokuda S, Nagira K, Olmer M, Gamini R, et al. FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis. Sci Transl Med. 2018;10: pubmed publisher
    ..articular cartilage of Col2Cre-TKO and AcanCreERT-TKO mice exhibited reduced cell density and markedly decreased Prg4 In vitro, ectopic FoxO1 expression increased Prg4 and synergized with transforming growth factor-β ..
  20. Liang M, Liu J, Ji H, Chen M, Zhao Y, Li S, et al. A Aconitum coreanum polysaccharide fraction induces apoptosis of hepatocellular carcinoma (HCC) cells via pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of the P13K/Akt and activation of p38 MAPK signaling pathway and displays antit. Tumour Biol. 2015;36:7085-91 pubmed publisher
    In this study, we observed that a Aconitum coreanum polysaccharide (CACP) exhibited an effective inhibitory effect on H22 cell growth in vitro and in vivo via the induction of apoptosis...
  21. Ritter S, Collins J, Krastins B, Sarracino D, Lopez M, Losina E, et al. Mass spectrometry assays of plasma biomarkers to predict radiographic progression of knee osteoarthritis. Arthritis Res Ther. 2014;16:456 pubmed publisher
    ..protein, hepatocyte growth factor, kallistatin, insulin-like growth factor binding protein, acid labile subunit, lubricin, lumican, and pigment epithelium-derived factor...
  22. Bomer N, Cornelis F, Ramos Y, den Hollander W, Storms L, van der Breggen R, et al. The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress. Ann Rheum Dis. 2016;75:571-7 pubmed publisher
    ..5 upon forced exercise. Among these are genes known for their association with OA (eg, Mef2c, Egfr, Ctgf, Prg4 and Ctnnb1), supporting the use of forced running as an OA model in mice...
  23. Bechtold T, Saunders C, Decker R, Um H, Cottingham N, Salhab I, et al. Osteophyte formation and matrix mineralization in a TMJ osteoarthritis mouse model are associated with ectopic hedgehog signaling. Matrix Biol. 2016;52-54:339-354 pubmed publisher
    ..Here we report that Proteoglycan 4 (Prg4)-null TMJs exhibit irreversible osteoarthritis-like changes over time and are linked to formation of ..
  24. Graziano A, Avola R, Pannuzzo G, Cardile V. Aquaporin1 and 3 modification as a result of chondrogenic differentiation of human mesenchymal stem cell. J Cell Physiol. 2017;: pubmed publisher
    ..derived from AT-MSCs were able to produce augmented content of GAGs and significant quantity of SOX-9, lubricin, aggrecan, and collagen type II, suggesting hyaline cartilage formation, in combination with an increase of AQP3 ..
  25. Thaware P, McKenna S, Patterson C, Hadden D, Pettitt D, McCance D. Untreated Mild Hyperglycemia During Pregnancy and Anthropometric Measures of Obesity in Offspring at Age 5-7 Years. Diabetes Care. 2015;38:1701-6 pubmed publisher
    ..in 5- to 7-year-old offspring whose mothers participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study at the Belfast Centre...
  26. Janune D, Abd El Kader T, Aoyama E, Nishida T, Tabata Y, Kubota S, et al. Novel role of CCN3 that maintains the differentiated phenotype of articular cartilage. J Bone Miner Metab. 2017;35:582-597 pubmed publisher
    ..that CCN3 increases the proteoglycan accumulation, the gene expression of type II collagen, tenascin-C and lubricin, as well as the protein production of tenascin-C and lubricin in articular chondrocytes...
  27. Ravalli S, Szychlinska M, Leonardi R, Musumeci G. Recently highlighted nutraceuticals for preventive management of osteoarthritis. World J Orthop. 2018;9:255-261 pubmed publisher
    ..olive oil to exert positive effects on the entire joint to reduce pro-inflammatory cytokine release and increase lubricin synthesis, olive leaf extract, since it maintains lubrication by stimulating high molecular weight hyaluronan ..
  28. Wang Q, Tan Q, Xu W, Qi H, Chen D, Zhou S, et al. Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice. Osteoarthritis Cartilage. 2017;25:1868-1879 pubmed publisher
    ..on articular cartilage homeostasis was explored by analyzing the TGF-β/ALK5 signaling-induced expression of proteoglycan 4 (PRG4) using specific inhibitors...
  29. Lui J, Chau M, Chen W, Cheung C, Hanson J, Rodriguez Canales J, et al. Spatial regulation of gene expression during growth of articular cartilage in juvenile mice. Pediatr Res. 2015;77:406-15 pubmed publisher
    ..Molecular markers were identified for superficial (e.g., Cilp, Prg4), middle (Cxcl14, Tnn), and deep zones (Sfrp5, Frzb)...
  30. Gargano L, Hajjeh R, Cookson S. Pneumonia prevention: Cost-effectiveness analyses of two vaccines among refugee children aged under two years, Haemophilus influenzae type b-containing and pneumococcal conjugate vaccines, during a humanitarian emergency, Yida camp, South Sudan. Vaccine. 2017;35:435-442 pubmed publisher
    ..Using Médecins Sans Frontières (MSF)-provided data and modifying our decision-tree models, we estimated if administering Haemophilus influenzae type b (..
  31. Jay G, Waller K. The biology of lubricin: near frictionless joint motion. Matrix Biol. 2014;39:17-24 pubmed publisher
    b>Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity...
  32. Oshima M, Hamba H, Sadr A, Nikaido T, Tagami J. Effect of polymer-based desensitizer with sodium fluoride on prevention of root dentin demineralization. Am J Dent. 2015;28:123-7 pubmed
    ..and 1% oxalic acid (MSO); and MS Coat F containing MS polymer, 1% oxalic acid and 3,000 ppm sodium fluoride (MSF). A window of the dentin surface was treated with each solution...
  33. Sharma D, Hayman K, Stewart B, Dominguez L, Trelles M, Saqeb S, et al. Care of surgical infections by Médecins Sans Frontières Operations Centre Brussels in 2008-14. Lancet. 2015;385 Suppl 2:S31 pubmed publisher
    ..Médecins Sans Frontières (MSF) provides surgical care in LMICs and collects data useful to describe the operative epidemiology of surgical need ..
  34. Veedfald S, Plamboeck A, Deacon C, Hartmann B, Knop F, Vilsbøll T, et al. Cephalic phase secretion of insulin and other enteropancreatic hormones in humans. Am J Physiol Gastrointest Liver Physiol. 2016;310:G43-51 pubmed publisher
    ..5 kg/m(2); HbA1c: 5.1 ± 0.1%/31.4 ± 0.5 mmol/mol). Cephalic activation was elicited by modified sham feeding (MSF, aka "chew and spit") with or without atropine (1 mg bolus 45 min before MSF + 80 ng·kg(-1)·min(-1) for 2 h)...
  35. Peters B, Schuurs Hoeijmakers J, Fuijkschot J, Reimer A, van der Flier M, Lugtenberg D, et al. Protein-losing enteropathy in camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome. Pediatr Rheumatol Online J. 2016;14:32 pubmed publisher
    ..Children with CACP syndrome lack the glycoprotein lubricin due to recessive mutations in PRG4...
  36. Zhu K, Yuan B, Hu M, Feng G, Liu Y, Liu J. Reduced abnormal integration of adult-generated granule cells does not attenuate spontaneous recurrent seizures in mice. Epilepsy Res. 2017;133:58-66 pubmed publisher
    ..delay after the cell ablation are required to eliminate subsequent abnormal integrations, including EGCs, MSF and HBDs...
  37. Caluwaerts S. Nubia's mother: being pregnant in the time of experimental vaccines and therapeutics for Ebola. Reprod Health. 2017;14:157 pubmed publisher
    During the 2014-2016 Ebola epidemic, Médecins Sans Frontières (MSF) treated Ebola-positive pregnant women in its Ebola Treatment Centers (ETCs)...
  38. Hamsawahini K, Sathishkumar P, Ahamad R, Yusoff A. A sensitive, selective and rapid determination of lead(II) ions in real-life samples using an electrochemically reduced graphene oxide-graphite reinforced carbon electrode. Talanta. 2015;144:969-76 pubmed publisher
    ..Factors influencing the detection of Pb(II) ions, such as grades of GRC, constant applied cathodic potential (CACP), concentration of hydrochloric acid and drop-casting drying time were optimised...
  39. Jiao J, Jensen W, Harreby K, Sevcencu C. The Effect of Spinal Cord Stimulation on Epileptic Seizures. Neuromodulation. 2016;19:154-60 pubmed publisher
    ..The means of normalized SW spike power (mSP) and frequency (mSF) were derived from the IC recordings and used to estimate the seizure severity...
  40. Samaroo K, Tan M, Putnam D, Bonassar L. Binding and lubrication of biomimetic boundary lubricants on articular cartilage. J Orthop Res. 2017;35:548-557 pubmed publisher
    The glycoprotein, lubricin, is the primary boundary lubricant of articular cartilage and has been shown to prevent cartilage damage after joint injury...
  41. Falq G, Van den Bergh R, de Smet M, Etienne W, Nguon C, Rekol H, et al. Assessing the asymptomatic reservoir and dihydroartemisinin-piperaquine effectiveness in a low transmission setting threatened by artemisinin resistant Plasmodium falciparum. Malar J. 2016;15:446 pubmed publisher
    ..Data from the provincial surveillance system targeting symptomatic cases, supported by Médecins Sans Frontières (MSF), were used to assess incidence. District P. falciparum prevalence was of 0.74 % [0.41; 1...
  42. Ji B, Zhang Z, Guo W, Ma H, Xu B, Mu W, et al. Isoliquiritigenin blunts osteoarthritis by inhibition of bone resorption and angiogenesis in subchondral bone. Sci Rep. 2018;8:1721 pubmed publisher
    ..ISL increased expression level of lubricin and decreased collagen X (Col X), matrix metalloproteinase-13 (MMP-13)...
  43. Thakkar K, Brascamp J, Ghermezi L, Fifer K, Schall J, Park S. Reduced pupil dilation during action preparation in schizophrenia. Int J Psychophysiol. 2018;128:111-118 pubmed publisher
    ..In the current study, 16 medicated outpatients with schizophrenia (SZP) and 18 healthy controls performed a task that measures the ability to reactively inhibit and modify a planned ..
  44. Zimmermann M, Caballé Serrano J, Bosshardt D, Ankersmit H, Buser D, Gruber R. Bone-Conditioned Medium Changes Gene Expression in Bone-Derived Fibroblasts. Int J Oral Maxillofac Implants. 2015;30:953-8 pubmed publisher
    ..The data show that ADM, IL11, IL33, NOX4, PRG4, and PTX3 were differentially expressed in response to BCM in bone-derived fibroblasts...
  45. Alquraini A, Garguilo S, D SOUZA G, Zhang L, Schmidt T, Jay G, et al. The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid. Arthritis Res Ther. 2015;17:353 pubmed publisher
    b>Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. PRG4 has a homeostatic multifaceted role in the joint...
  46. Szychlinska M, Trovato F, Di Rosa M, Malaguarnera L, Puzzo L, Leonardi R, et al. Co-Expression and Co-Localization of Cartilage Glycoproteins CHI3L1 and Lubricin in Osteoarthritic Cartilage: Morphological, Immunohistochemical and Gene Expression Profiles. Int J Mol Sci. 2016;17:359 pubmed publisher
    ..as a potential marker for the activation of chondrocytes and the progression of Osteoarthritis (OA), whereas lubricin appears to be chondroprotective...
  47. Nikolaides A, Miess S, Auvera I, Muller R, Klosterkotter J, Ruhrmann S. Restricted attention to social cues in schizophrenia patients. Eur Arch Psychiatry Clin Neurosci. 2016;266:649-61 pubmed publisher
    ..As a correlate of social perceptive information processing deficits, schizophrenia patients (SZP) show deviant gaze behavior (GB) while viewing emotional faces...
  48. Donovan L, Edwards A, Savu A, Butalia S, Ryan E, Johnson J, et al. Population-Level Outcomes with a 2-Step Approach for Gestational Diabetes Screening and Diagnosis. Can J Diabetes. 2017;41:596-602 pubmed publisher
    ..abnormal at glucose thresholds suggested by the International Association of Diabetes and Pregnancy Group (IADPSG) (HAPO 1.75, n=4308); abnormal at glucose thresholds associated with an odds ratio of 2...
  49. Ahaotu N, Anyogu A, Obioha P, Aririatu L, Ibekwe V, Oranusi S, et al. Influence of soy fortification on microbial diversity during cassava fermentation and subsequent physicochemical characteristics of garri. Food Microbiol. 2017;66:165-172 pubmed publisher
    ..Malted soy flour (MSF) and soy protein (SP) were separately added (12% w/w) to cassava mash prior to controlled fermentation, while non-..
  50. Osmers I. [Orthopedic surgery with limited resources after mass disasters and during armed conflicts : First international guidelines for the management of limb injuries and the experience of Doctors Without Borders]. Unfallchirurg. 2017;120:815-822 pubmed publisher
    ..are often the unfortunate basis for aid projects run by Doctors Without Borders/Médecins Sans Frontières (MSF). The nature of war and disasters means that surgery is an integral part of this medical emergency aid...
  51. Taşar M, Eyileten Z, Kasımzade F, Uçar T, Kendirli T, Uysalel A. Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome. Turk J Pediatr. 2014;56:684-6 pubmed
    Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome is a rare autosomal recessive congenital disorder that includes childhood-onset camptodactyly, synovial hyperplasia-related arthropathy, progressive coxa vara deformity and ..
  52. Hill A, Cairnduff V, McCance D. Nutritional and clinical associations of food cravings in pregnancy. J Hum Nutr Diet. 2016;29:281-9 pubmed publisher
    ..pregnant women were participants in the Belfast cohort of the Hyperglycaemia and Adverse Pregnancy Outcome study (HAPO), a prospective observational study examining maternal glycaemia and pregnancy outcome...
  53. Lieff S, Zaretsky A, Bandiera G, Imrie K, Spadafora S, Glover Takahashi S. What do I do? Developing a competency inventory for postgraduate (residency) program directors. Med Teach. 2016;38:1011-1016 pubmed
    ..Program Director Competency Inventory (PPDCI) in order to frame the performance of PDs for a multisource feedback (MSF) program...
  54. Lambiase A, Sullivan B, Schmidt T, Sullivan D, Jay G, Truitt E, et al. A Two-Week, Randomized, Double-masked Study to Evaluate Safety and Efficacy of Lubricin (150 μg/mL) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops (Vismed®) in Patients with Moderate Dry Eye Disease. Ocul Surf. 2017;15:77-87 pubmed publisher
    The objective of this clinical trial (NCT02507934) was to assess the efficacy and safety of recombinant human lubricin as compared to a 0.18% sodium hyaluronate (HA) eye drop in subjects with moderate dry eye disease (DED)...
  55. Royaux E, Van Ham L, Broeckx B, Van Soens I, Gielen I, Deforce D, et al. Phenobarbital or potassium bromide as an add-on antiepileptic drug for the management of canine idiopathic epilepsy refractory to imepitoin. Vet J. 2017;220:51-54 pubmed publisher
    ..The efficacy of phenobarbital and KBr was evaluated by comparing monthly seizure frequency (MSF), monthly seizure day frequency (MSDF), the presence of cluster seizures during a retrospective 2-month period with ..
  56. Flowers S, Kalamajski S, Ali L, Björkman L, Raj J, Aspberg A, et al. Cartilage oligomeric matrix protein forms protein complexes with synovial lubricin via non-covalent and covalent interactions. Osteoarthritis Cartilage. 2017;25:1496-1504 pubmed publisher
    ..Given that adherence of the lubricating protein, lubricin, to the cartilage surface is critical for boundary lubrication, an interaction with cartilage oligomeric matrix ..
  57. Lockyer J, Hodgson C, Lee T, Faremo S, Fisher B, Dafoe W, et al. Clinical teaching as part of continuing professional development: Does teaching enhance clinical performance?. Med Teach. 2016;38:815-22 pubmed publisher
    ..determine whether there were differences in clinical performance scores as assessed through multisource feedback (MSF) data based on clinical teaching...
  58. Pawlak Z, Gadomski A, Sojka M, Urbaniak W, Bełdowski P. The amphoteric effect on friction between the bovine cartilage/cartilage surfaces under slightly sheared hydration lubrication mode. Colloids Surf B Biointerfaces. 2016;146:452-8 pubmed publisher
    ..the extracellular matrix (ECM) collagen fibers, hyaluronate, proteoglycans aggregates (PGs), glycoprotein termed lubricin and finally, lamellar PLs phases...
  59. Briciu A. Diurnal, semidiurnal, and fortnightly tidal components in orthotidal proglacial rivers. Environ Monit Assess. 2018;190:160 pubmed publisher
    ..Tidal components with 0.95 confidence level are as follows: O1, PI1, P1, S1, K1, PSI1, M2, T2, S2, K2, and MSf. The amplitude of the diurnal tidal constituents is strongly influenced by the daily thermal cycle...
  60. Fournier N, Cogny A, Atger V, Pastier D, Goudouneche D, Nicoletti A, et al. Opposite effects of plasma from human apolipoprotein A-II transgenic mice on cholesterol efflux from J774 macrophages and Fu5AH hepatoma cells. Arterioscler Thromb Vasc Biol. 2002;22:638-43 pubmed
    Overexpression of human apolipoprotein A-II (hapo A-II) in transgenic mice (hAIItg mice) induced marked hypertriglyceridemia and low levels of plasma high density lipoprotein (HDL) with a high hapo A-II content...
  61. Solka K, Miller I, Schmid T. Sialidase Unmasks Mucin Domain Epitopes of Lubricin. J Histochem Cytochem. 2016;64:647-668 pubmed publisher
    b>Lubricin is a secreted, mucin-like glycoprotein and proteoglycan abundant in synovial fluid that provides boundary lubrication and prevents cell adhesion in synovial joints. The antilubricin S6...
  62. Blaney Davidson E, van Caam A, van der Kraan P. Osteoarthritis year in review 2016: biology. Osteoarthritis Cartilage. 2017;25:175-180 pubmed publisher
    ..This covers circadian rhythm, TGF-β signaling, autophagy, SIRT6, exercise, lubricin, TLR's, pain and NGF...
  63. Lin Y, Dahm J, Kushner A, Lawrence J, Trelles M, Dominguez L, et al. Are American Surgical Residents Prepared for Humanitarian Deployment?: A Comparative Analysis of Resident and Humanitarian Case Logs. World J Surg. 2018;42:32-39 pubmed publisher
    ..Education general surgery graduates from 2009 to 2015 and cases performed at select Médecins Sans Frontières (MSF) facilities from 2008 to 2012...
  64. Šabanagić Hajrić S, Suljic E, Kucukalic A. Fatigue during multiple sclerosis relapse and its relationship to depression and neurological disability. Psychiatr Danub. 2015;27:406-12 pubmed
    ..All patients were examined at the same appointment. 54 (45%) patients were grouped into MS fatigue (MSF) group (FSS≥5) and 48 (40%) as non-fatigue (MSNF) group (FSS≤4). Mean FSS score was 4.83+/-1.49...
  65. Segura F, Pons I, Sanfeliu I, Nogueras M. Shell-vial culture, coupled with real-time PCR, applied to Rickettsia conorii and Rickettsia massiliae-Bar29 detection, improving the diagnosis of the Mediterranean spotted fever. Ticks Tick Borne Dis. 2016;7:457-61 pubmed publisher
    Rickettsia conorii and Rickettsia massiliae-Bar29 are related to Mediterranean spotted fever (MSF). They are intracellular microorganisms...
  66. Reesink H, Bonnevie E, Liu S, Shurer C, Hollander M, Bonassar L, et al. Galectin-3 Binds to Lubricin and Reinforces the Lubricating Boundary Layer of Articular Cartilage. Sci Rep. 2016;6:25463 pubmed publisher
    b>Lubricin is a mucinous, synovial fluid glycoprotein that enables near frictionless joint motion via adsorption to the surface of articular cartilage and its lubricating properties in solution...
  67. Teeple E, Karamchedu N, Larson K, Zhang L, Badger G, Fleming B, et al. Arthroscopic irrigation of the bovine stifle joint increases cartilage surface friction and decreases superficial zone lubricin. J Biomech. 2016;49:3106-3110 pubmed publisher
    The purpose of this study was to determine the effects of arthroscopic irrigation on cartilage superficial zone lubricin and surface friction...
  68. Hermans V, Zachariah R, Woldeyohannes D, Saffa G, Kamara D, Ortuno Gutierrez N, et al. Offering general pediatric care during the hard times of the 2014 Ebola outbreak: looking back at how many came and how well they fared at a Médecins Sans Frontières referral hospital in rural Sierra Leone. BMC Pediatr. 2017;17:34 pubmed publisher
    ..at a primary health center and the quality of care for under-15 children at a Médecins Sans Frontières (MSF) referral hospital...
  69. Torpiano P, Pace D. Clinically-diagnosed Mediterranean Spotted Fever in Malta. Travel Med Infect Dis. 2018;26:16-24 pubmed publisher
    Mediterranean Spotted Fever (MSF) is a tick-borne zoonosis caused by Rickettsia conorii which is endemic in Malta, an island in the South Mediterranean that is a popular tourist destination...
  70. Waters T, Dyer A, Scholtens D, Dooley S, Herer E, Lowe L, et al. Maternal and Neonatal Morbidity for Women Who Would Be Added to the Diagnosis of GDM Using IADPSG Criteria: A Secondary Analysis of the Hyperglycemia and Adverse Pregnancy Outcome Study. Diabetes Care. 2016;39:2204-2210 pubmed
    ..and Pregnancy Study Groups (IADPSG) criteria using data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study. This is a secondary analysis from the North American HAPO study centers...
  71. Mani K, Sandgren S, Lilja J, Cheng F, Svensson K, Persson L, et al. HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells. Mol Cancer Ther. 2007;6:782-8 pubmed
    ..We conclude that HIV-Tat transduction domain and polyamines enter cells through a common pathway, which can be used to target polyamine-dependent tumor growth in the treatment of cancer. ..
  72. Samsom M, Morrison S, Masala N, Sullivan B, Sullivan D, Sheardown H, et al. Characterization of full-length recombinant human Proteoglycan 4 as an ocular surface boundary lubricant. Exp Eye Res. 2014;127:14-9 pubmed publisher
    b>Proteoglycan 4 (PRG4, or lubricin) is a lubricating mucin-like glycoprotein recently discovered at the ocular surface, where it functions as a boundary lubricant and appears to play a protective role...
  73. Askary A, Smeeton J, Paul S, Schindler S, Braasch I, Ellis N, et al. Ancient origin of lubricated joints in bony vertebrates. elife. 2016;5: pubmed publisher
    ..Here, we examine the expression and function of a critical lubricating protein of mammalian synovial joints, Prg4/Lubricin, in diverse ray-finned fishes...
  74. Middendorf J, Griffin D, Shortkroff S, Dugopolski C, Kennedy S, Siemiatkoski J, et al. Mechanical properties and structure-function relationships of human chondrocyte-seeded cartilage constructs after in vitro culture. J Orthop Res. 2017;35:2298-2306 pubmed publisher
    ..Similarly, immunohistochemistry revealed increased lubricin localization on the construct surface...
  75. Tabib T, Morse C, Wang T, Chen W, Lafyatis R. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin. J Invest Dermatol. 2018;138:802-810 pubmed publisher
    ..and FMO1 populations and five minor fibroblast populations, each expressing discrete genes: CRABP1, COL11A1, FMO2, PRG4, or C2ORF40...
  76. Ludwig T, Cowman M, Jay G, Schmidt T. Effects of concentration and structure on proteoglycan 4 rheology and interaction with hyaluronan. Biorheology. 2014;51:409-22 pubmed publisher
    The contribution of proteoglycan 4 (PRG4) to synovial fluid and hyaluronan (HA) solution rheology are poorly understood...
  77. Oikawa K, Mizusaki A, Takanashi M, Ozaki T, Sato F, Kuroda M, et al. PRG4 expression in myxoid liposarcoma maintains tumor cell growth through suppression of an antitumor cytokine IL-24. Biochem Biophys Res Commun. 2017;485:209-214 pubmed publisher
    b>PRG4 is one of the downstream molecules of the myxoid liposarcoma (MLS)-specific fusion oncoproteins TLS-CHOP and EWS-CHOP. Exogenous PRG4 expression increases the tumorigenicity of cells injected in nude mice...
  78. Song L, Li Y, Xiong Z, Pan L, Luo Q, Xu X, et al. Water-Induced shape memory effect of nanocellulose papers from sisal cellulose nanofibers with graphene oxide. Carbohydr Polym. 2018;179:110-117 pubmed publisher
    ..were prepared by introducing graphene oxide (GO), which was based on microcrystalline cellulose nanofibers (MSF-g-COOH) extracting from sisal fibers...
  79. Jay G, Britt D, Cha C. Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts. J Rheumatol. 2000;27:594-600 pubmed
    ..Sequences specific for megakaryocyte stimulating factor precursor (MSF) were identified in GenBank. A 100% match was observed for exons 6 though 9 of MSF...
  80. Chang D, Guilak F, Jay G, Zauscher S. Interaction of lubricin with type II collagen surfaces: adsorption, friction, and normal forces. J Biomech. 2014;47:659-66 pubmed publisher
    ..fluid that is thought to be responsible for chondroprotection and boundary lubrication is the glycoprotein lubricin (PRG4); however, the molecular mechanisms by which lubricin carries out its critical functions still remain ..
  81. Trelles M, Stewart B, Hemat H, Naseem M, Zaheer S, Zakir M, et al. Averted health burden over 4 years at Médecins Sans Frontières (MSF) Trauma Centre in Kunduz, Afghanistan, prior to its closure in 2015. Surgery. 2016;160:1414-1421 pubmed publisher
  82. Sluzalska K, Liebisch G, Lochnit G, Ishaque B, Hackstein H, Schmitz G, et al. Interleukin-1? affects the phospholipid biosynthesis of fibroblast-like synoviocytes from human osteoarthritic knee joints. Osteoarthritis Cartilage. 2017;25:1890-1899 pubmed publisher
    Phospholipids (PLs), together with hyaluronan and lubricin, are involved in boundary lubrication within human articular joints...
  83. Guan J, Lin J, Ma Y, Tan J, Jin P. A subwavelength spot and a three-dimensional optical trap formed by a single planar element with azimuthal light. Sci Rep. 2017;7:7380 pubmed publisher
    ..under the illumination of an azimuthally polarized (AP) beam by only a single planar element, a spiral zone plate (SZP). Initially, the SZP was proposed as a computer-generated hologram to generate optical phase singularities...
  84. Wanderling C, Liles J, Davis E, Schmitt D, Statz S, Guler N, et al. Levels of Matrix-Degrading Enzymes and Lubricin in Patients With Degenerative Joint Disease Requiring Arthroplasty. Clin Appl Thromb Hemost. 2018;24:41-46 pubmed publisher
    ..The aim of this study is to profile collagenase-1, elastase, heparanase, and lubricin levels in patients undergoing TJA in order to determine potential preexisting dysregulation that contributes to ..
  85. Cheriyan T, Guo L, Orgill D, Padera R, Schmid T, Spector M. Lubricin in human breast tissue expander capsules. J Biomed Mater Res B Appl Biomater. 2012;100:1961-9 pubmed publisher
    ..The objective of this study was to investigate the possible role of lubricin in capsular formation and contraction by determining the presence and distribution of the lubricating protein ..
  86. Shekhawat V, Schmid T, Pennekamp P, Pacione C, Chubinskaya S, Wimmer M. Implications of trauma and subsequent articulation on the release of Proteoglycan-4 and tissue response in adult human ankle cartilage. J Orthop Res. 2017;35:667-676 pubmed publisher
    ..02) as compared to non-impacted cartilage explants. One of the key findings was that damage also stimulated the PRG4 release (2.2 vs. 1.5??g/ml)...
  87. Mesić A, Fontaine J, Aye T, Greig J, Thwe T, Moretó Planas L, et al. Implications of differentiated care for successful ART scale-up in a concentrated HIV epidemic in Yangon, Myanmar. J Int AIDS Soc. 2017;20:21644 pubmed publisher
    ..This study describes implementation of differentiated care in Médecins Sans Frontières (MSF)-supported programmes and reports its outcomes.
  88. Massaut J, Valles P, Ghismonde A, Jacques C, Louis L, Zakir A, et al. The modified south African triage scale system for mortality prediction in resource-constrained emergency surgical centers: a retrospective cohort study. BMC Health Serv Res. 2017;17:594 pubmed publisher
    ..to facilitate patient triage in emergency departments (EDs) and is used by Médecins Sans Frontières (MSF) in low-resource environments...
  89. Bekolo C, Diallo A, Philips M, Yuma J, Di Stefano L, Drèze S, et al. Six-monthly appointment spacing for clinical visits as a model for retention in HIV Care in Conakry-Guinea: a cohort study. BMC Infect Dis. 2017;17:766 pubmed publisher
    ..Meanwhile, Médecins Sans Frontières (MSF) was implementing a six-monthly appointment spacing approach adapted locally as Rendez-vous de Six Mois (R6M) with ..
  90. Swann D, Silver F, Slayter H, Stafford W, Shore E. The molecular structure and lubricating activity of lubricin isolated from bovine and human synovial fluids. Biochem J. 1985;225:195-201 pubmed
    b>Lubricin was isolated from bovine ankle, metacarpophalangeal and knee and human knee synovial fluids...
  91. Nove A, Hoope Bender P, Moyo N, Bokosi M. The Midwifery services framework: What is it, and why is it needed?. Midwifery. 2018;57:54-58 pubmed publisher
    ..This first of a series of three papers introduces the MSF, explains why it is needed, how it was developed, its guiding principles and its anticipated outcomes and impact...
  92. Zhou Y, Liang K, Zhao S, Zhang C, Li J, Yang H, et al. Photopolymerized maleilated chitosan/methacrylated silk fibroin micro/nanocomposite hydrogels as potential scaffolds for cartilage tissue engineering. Int J Biol Macromol. 2018;108:383-390 pubmed publisher
    ..Herein, the natural polymers with vinyl groups, i.e. maleilated chitosan (MCS) and methacrylated silk fibroin (MSF) micro/nanoparticles, were firstly synthesized...