PRDX5

Summary

Gene Symbol: PRDX5
Description: peroxiredoxin 5
Alias: ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, SBBI10, prx-V, peroxiredoxin-5, mitochondrial, Alu co-repressor 1, TPx type VI, antioxidant enzyme B166, epididymis secretory protein Li 55, liver tissue 2D-page spot 71B, peroxiredoxin V, peroxisomal antioxidant enzyme, thioredoxin peroxidase PMP20, thioredoxin reductase
Species: human
Products:     PRDX5

Top Publications

  1. Declercq J, Evrard C, Clippe A, Stricht D, Bernard A, Knoops B. Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution. J Mol Biol. 2001;311:751-9 pubmed
    ..Peroxiredoxins have been identified in prokaryotes as well as in eukaryotes. Peroxiredoxin 5 (PRDX5) is a novel type of mammalian thioredoxin peroxidase widely expressed in tissues and located cellularly to ..
  2. Trujillo M, Clippe A, Manta B, Ferrer Sueta G, Smeets A, Declercq J, et al. Pre-steady state kinetic characterization of human peroxiredoxin 5: taking advantage of Trp84 fluorescence increase upon oxidation. Arch Biochem Biophys. 2007;467:95-106 pubmed
    Human peroxiredoxin 5 (PRDX5) catalyzes different peroxides reduction by enzymatic substitution mechanisms. Enzyme oxidation caused an increase in Trp84 fluorescence, allowing performing pre-steady state kinetic measurements...
  3. Banmeyer I, Marchand C, Clippe A, Knoops B. Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide. FEBS Lett. 2005;579:2327-33 pubmed
    ..Altogether our results suggest that mitochondrial peroxiredoxin 5 may play an important role in mitochondrial genome stability. ..
  4. Knoops B, Clippe A, Bogard C, Arsalane K, Wattiez R, Hermans C, et al. Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family. J Biol Chem. 1999;274:30451-8 pubmed
    ..Here, we report the cloning of human and rat cDNAs encoding B166, which has been renamed AOEB166 for antioxidant enzyme B166. Indeed, the deduced amino acid sequence reveals that AOEB166 represents a new mammalian subfamily of ..
  5. De Simoni S, Goemaere J, Knoops B. Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP+. Neurosci Lett. 2008;433:219-24 pubmed publisher
    Peroxiredoxins (PRDXs) are a family of peroxidases well conserved throughout evolution. Human PRDX3 and PRDX5, two mitochondrial PRDXs, have been implicated in several pathologies associated with oxidative stress...
  6. Kropotov A, Sedova V, Ivanov V, Sazeeva N, Tomilin A, Krutilina R, et al. A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase-III-driven transcription of the Alu-family retroposons in vitro. Eur J Biochem. 1999;260:336-46 pubmed
    ..A human cDNA clone encoding this protein (ACR1) was isolated from a human expression library using South-western screening with an Alu subfragment, implicated in ..
  7. Smeets A, Marchand C, Linard D, Knoops B, Declercq J. The crystal structures of oxidized forms of human peroxiredoxin 5 with an intramolecular disulfide bond confirm the proposed enzymatic mechanism for atypical 2-Cys peroxiredoxins. Arch Biochem Biophys. 2008;477:98-104 pubmed publisher
    Peroxiredoxin 5 (PRDX5) belongs to the PRDX superfamily of thiol-dependent peroxidases able to reduce hydrogen peroxide, alkyl hydroperoxides and peroxynitrite. PRDX5 is classified in the atypical 2-Cys subfamily of PRDXs...
  8. Zhou Y, Kok K, Chun A, Wong C, Wu H, Lin M, et al. Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis. Biochem Biophys Res Commun. 2000;268:921-7 pubmed
    ..We have identified human and mouse peroxiredoxin V (Prx-V) by virtue of the sequence homologies to yeast peroxisomal antioxidant enzyme PMP20. Prx-V represents the fifth of the six currently known subfamilies of mammalian peroxiredoxins...
  9. Nguyên Nhu N, Berck J, Clippe A, Duconseille E, Cherif H, Boone C, et al. Human peroxiredoxin 5 gene organization, initial characterization of its promoter and identification of alternative forms of mRNA. Biochim Biophys Acta. 2007;1769:472-83 pubmed
    Peroxiredoxin 5 (PRDX5) is a mammalian thioredoxin peroxidase ubiquitously expressed in tissues. Its role as antioxidant enzyme has been previously supported in different pathological situations...

More Information

Publications78

  1. Dubuisson M, Vander Stricht D, Clippe A, Etienne F, Nauser T, Kissner R, et al. Human peroxiredoxin 5 is a peroxynitrite reductase. FEBS Lett. 2004;571:161-5 pubmed
    ..Moreover, with the use of pulse radiolysis, we show that human peroxiredoxin 5 reduces peroxynitrite with an unequalled high rate constant of (7+/-3)x10(7) M(-1)s(-1). ..
  2. Wang M, Wei A, Yuan J, Clippe A, Bernard A, Knoops B, et al. Antioxidant enzyme peroxiredoxin 5 is upregulated in degenerative human tendon. Biochem Biophys Res Commun. 2001;284:667-73 pubmed
    Peroxiredoxin 5 (PRDX5) is a novel thioredoxin peroxidase recently identified in a variety of human cells and tissues, which is considered to play an important role in oxidative stress protection mechanisms...
  3. Usmanova N, Tomilin N, Zhivotovsky B, Kropotov A. Transcription factor GABP/NRF-2 controlling biogenesis of mitochondria regulates basal expression of peroxiredoxin V but the mitochondrial function of peroxiredoxin V is dispensable in the dog. Biochimie. 2011;93:306-13 pubmed publisher
    ..Human PRDX5 is detected in the cytosol and nucleus and can also target peroxisomes and mitochondria...
  4. Barelier S, Linard D, Pons J, Clippe A, Knoops B, Lancelin J, et al. Discovery of fragment molecules that bind the human peroxiredoxin 5 active site. PLoS ONE. 2010;5:e9744 pubmed publisher
    ..This study reports novel data about the ligand-Peroxiredoxin interactions that will help considerably the development of potential Peroxiredoxin inhibitors. ..
  5. Banmeyer I, Marchand C, Verhaeghe C, Vucic B, Rees J, Knoops B. Overexpression of human peroxiredoxin 5 in subcellular compartments of Chinese hamster ovary cells: effects on cytotoxicity and DNA damage caused by peroxides. Free Radic Biol Med. 2004;36:65-77 pubmed
  6. Seo M, Kang S, Kim K, Baines I, Lee T, Rhee S. Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. J Biol Chem. 2000;275:20346-54 pubmed
    ..A new type of mammalian Prx, designated PrxV, has now been identified as the result of a data base search with this conserved Cys-containing sequence...
  7. Yamashita H, Avraham S, Jiang S, London R, Van Veldhoven P, Subramani S, et al. Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro. J Biol Chem. 1999;274:29897-904 pubmed
    ..isolated the cDNAs encoding human and mouse homologues of a yeast protein, termed peroxisomal membrane protein 20 (PMP20)...
  8. Knoops B, Goemaere J, Van Der Eecken V, Declercq J. Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin. Antioxid Redox Signal. 2011;15:817-29 pubmed publisher
    Peroxiredoxin 5 (PRDX5) was the last member to be identified among the six mammalian peroxiredoxins. It is also the unique atypical 2-Cys peroxiredoxin in mammals...
  9. Kurpińska A, Suraj J, Bonar E, Zakrzewska A, Stojak M, Sternak M, et al. Proteomic characterization of early lung response to breast cancer metastasis in mice. Exp Mol Pathol. 2019;107:129-140 pubmed publisher
    ..1 Q subcomponent-binding protein, mitochondrial (C1qbp), 14-3-3 protein zeta/delta (Ywhaz), peroxiredoxin-6 (Prdx6), chitinase-like protein 4 (Chi3l4), reticulocalbin-1 (Rcn1), EF-hand domain-containing protein D2 (Efhd2), ..
  10. Hoffman R, Tan Y, Li S, Han Q, Yagi S, Takakura T, et al. Development of Recombinant Methioninase for Cancer Treatment. Methods Mol Biol. 2019;1866:107-131 pubmed publisher
    ..Miniosmotic pumps containing various concentrations of PLP were implanted in BALB-C mice...
  11. Majewski M, Kozlowska A, Thoene M, Lepiarczyk E, Grzegorzewski W. Overview of the role of vitamins and minerals on the kynurenine pathway in health and disease. J Physiol Pharmacol. 2016;67:3-19 pubmed
    ..A reduction in the availability of the active form of vitamin B6 (pyridoxal 5'-phosphate, PLP) is known to affect tryptophan hydroxylase, kynurenine aminotransferase and kynureninase (KYNU)...
  12. Ramirez Garcia A, Pellon A, Buldain I, Antoran A, Arbizu Delgado A, Guruceaga X, et al. Proteomics as a Tool to Identify New Targets Against Aspergillus and Scedosporium in the Context of Cystic Fibrosis. Mycopathologia. 2018;183:273-289 pubmed publisher
    ..chitosanase, dipeptidyl-peptidase V (DppV), the metalloprotease Asp f 5, mitogillin/Asp f 1, and thioredoxin reductase receive a special mention...
  13. Rios Avila L, Coats B, Ralat M, Chi Y, Midttun Ã, Ueland P, et al. Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users. Am J Clin Nutr. 2015;102:616-25 pubmed publisher
    ..An insufficiency of cellular pyridoxal 5'-phosphate (PLP), which is the coenzyme form of vitamin B-6, may impair many metabolic processes including one-carbon and ..
  14. Deac O, Mills J, Gardiner C, Shane B, Quinn L, Midttun Ø, et al. Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults. J Nutr. 2016;146:1801-6 pubmed publisher
    ..of serum tryptophan/kynurenine metabolites, neopterin, C-reactive protein (CRP), and plasma pyridoxal 5'-phosphate (PLP) with LC-tandem mass spectrometry methodologies...
  15. Ingwersen J, Wingerath B, Graf J, Lepka K, Hofrichter M, Schröter F, et al. Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation. J Neuroinflammation. 2016;13:48 pubmed publisher
    ..immunization in C57BL/6 with myelin oligodendrocyte glycoprotein (MOG)35-55 or transfer-EAE by proteolipid protein (PLP)139-155-stimulated T lymphocytes and EAE in mice treated with A2aR-agonist CGS21680 at different stages of disease ..
  16. Jurkowska H, Kaczor Kamińska M, Bronowicka Adamska P, Wróbel M. [Cystathionine γ-lyase]. Postepy Hig Med Dosw (Online). 2014;68:1-9 pubmed publisher
    ..Human, tetrameric CTH is composed of two dimers and each monomer binds pyridoxal phosphate (PLP). The gene, located on the short arm of chromosome 1, consists of 13 exons and 12 introns...
  17. Liu N, Liu Z, Lu S, Hu P, Li Y, Feng X, et al. Full-length cDNA cloning, molecular characterization and differential expression analysis of peroxiredoxin 6 from Ovis aries. Vet Immunol Immunopathol. 2015;164:208-19 pubmed publisher
    Peroxiredoxin 6 (Prdx6), an important antioxidant enzyme that can eliminate reactive oxygen species (ROS) to maintain homeostasis, is a bifunctional protein that possesses the activities of both glutathione peroxidase and phospholipase ..
  18. Sanchez I, Balagué E, Matilla Dueñas A. Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3?-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1). Hum Mol Genet. 2016;25:4021-4040 pubmed publisher
    ..complex,subunit A (SDHA), ATP synthase subunit d, mitochondrial (ATP5H)] and oxidative stress [peroxiredoxin-6 (PRDX6), aldehyde dehydrogenase family 1, subfamily A1, 10-formyltetrahydrofolate dehydrogenase]...
  19. Zhuang Y, Yang F, Xu D, Chen H, Zhang H, Liu G. Spliced leader-based analyses reveal the effects of polycyclic aromatic hydrocarbons on gene expression in the copepod Pseudodiaptomus poplesia. Aquat Toxicol. 2017;183:114-126 pubmed publisher
    ..Significant upregulation was detected in GST-T, GST-DE, GPX4, PRDX6 and RAC1 upon 1, 2-NAPH exposure, and GST-DE and MSDH upon pyrene exposure...
  20. Whyte M. Hypophosphatasia: An overview For 2017. Bone. 2017;102:15-25 pubmed publisher
    ..entry of minerals into the skeleton can cause hypercalcemia, and insufficient hydrolysis of pyridoxal 5'-phosphate (PLP), the major circulating form of vitamin B6, can cause pyridoxine-dependent seizures...
  21. Gulyaeva A, Dunowska M, Hoogendoorn E, Giles J, Samborskiy D, Gorbalenya A. Domain Organization and Evolution of the Highly Divergent 5' Coding Region of Genomes of Arteriviruses, Including the Novel Possum Nidovirus. J Virol. 2017;91: pubmed publisher
    ..Unexpectedly, our analysis revealed that the only catalytically active nsp1 PLP of equine arteritis virus (EAV), known as PLP1b, is most similar to PLP1c and thus is likely to be a PLP1b paralog...
  22. Deac O, Mills J, Shane B, Midttun Ã, Ueland P, Brosnan J, et al. Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults. J Nutr. 2015;145:701-7 pubmed publisher
    ..In all participants, serum Trp was positively associated with plasma pyridoxal 5'-phosphate (PLP; r = 0.28, P < 0.0001), reaching a plateau at PLP concentrations of ∼83 nmol/L...
  23. Ulvik A, Hustad S, McCann A, Midttun Ø, Nygård O, Ueland P. Ratios of One-Carbon Metabolites Are Functional Markers of B-Vitamin Status in a Norwegian Coronary Angiography Screening Cohort. J Nutr. 2017;147:1167-1173 pubmed publisher
    ..of B-vitamin status represented by a summary score composed of folate, cobalamin, betaine, pyridoxal 5'-phosphate (PLP), and riboflavin concentrations measured in plasma...
  24. Druzhyna N, Szczesny B, Olah G, Módis K, Asimakopoulou A, Pavlidou A, et al. Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of c. Pharmacol Res. 2016;113:18-37 pubmed publisher
    ..Drug Collection, the International Drug Collection, the 'Killer Plates' collection and a small custom collection of PLP-dependent enzyme inhibitors), we conducted an in vitro screen in order to identify inhibitors for CBS using a ..
  25. Nichols T, Gaiteri C. Morton's foot and pyridoxal 5'-phosphate deficiency: genetically linked traits. Med Hypotheses. 2014;83:644-8 pubmed publisher
    ..It exists as several vitamins forms but pyridoxal 5'-phosphate (PLP) is the phosphorylated form needed for transamination, deamination, and decarboxylation...
  26. Ahmadi H, Ramezani M, Yazdian Robati R, Behnam B, Razavi Azarkhiavi K, Hashem Nia A, et al. Acute toxicity of functionalized single wall carbon nanotubes: A biochemical, histopathologic and proteomics approach. Chem Biol Interact. 2017;275:196-209 pubmed publisher
    ..protein (Selenbp), thioredoxin peroxidase (TPx), TNF receptor associated protein 1(Trap1), peroxiredoxin-6 (Prdx6), electron transport flavoprotein (Etf-?), regucalcin (Rgn) and ATP5b proteins were differentially expressed in ..
  27. Gérard A, Many M, Daumerie C, Knoops B, Colin I. Peroxiredoxin 5 expression in the human thyroid gland. Thyroid. 2005;15:205-9 pubmed
    Peroxiredoxin 5 (PRDX5) is a newly discovered thioredoxin peroxidase able to reduce peroxides that is implicated in antioxidant protective mechanisms. We report here its expression in the human thyroid gland...
  28. Inouye H, Kirschner D. Evolution of myelin ultrastructure and the major structural myelin proteins. Brain Res. 2016;1641:43-63 pubmed publisher
    ..Proteolipid protein (PLP) is a major component only in the CNS myelin of terrestrial species and is involved in compaction of the ..
  29. Zuo H, Ueland P, Midttun Ø, Vollset S, Tell G, Theofylaktopoulou D, et al. Results from the European Prospective Investigation into Cancer and Nutrition Link Vitamin B6 Catabolism and Lung Cancer Risk. Cancer Res. 2018;78:302-308 pubmed publisher
    Circulating pyridoxal-5'-phosphate (PLP) has been linked to lung cancer risk. The PAr index, defined as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during inflammation...
  30. Jurkunas U, Rawe I, Bitar M, Zhu C, Harris D, Colby K, et al. Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy. Invest Ophthalmol Vis Sci. 2008;49:2956-63 pubmed publisher
    ..Significantly decreased expression of Prx-2, -3, and -5 in FED may suggest an alteration in the ability of endothelial cells to withstand oxidant-induced damage and may be closely related to the pathogenesis of this disease. ..
  31. Walton P, Brees C, Lismont C, Apanasets O, Fransen M. The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress. Biochim Biophys Acta Mol Cell Res. 2017;1864:1833-1843 pubmed publisher
    ..redox state especially interfere with the subcellular localization of catalase, the most abundant peroxisomal antioxidant enzyme. This study aimed at gaining more insight into this phenomenon...
  32. Prologo J, Gilliland C, Miller M, Harkey P, Knight J, Kies D, et al. Percutaneous Image-Guided Cryoablation for the Treatment of Phantom Limb Pain in Amputees: A Pilot Study. J Vasc Interv Radiol. 2017;28:24-34.e4 pubmed publisher
    ..To prospectively evaluate percutaneous image-guided nerve cryoablation for treatment of refractory phantom limb pain (PLP) in a pilot cohort for purposes of deriving parameters to design a larger, randomized, parallel-armed, controlled ..
  33. Martinez A, McMahon R, Horner M, Miller W. A uniform-shear rate microfluidic bioreactor for real-time study of proplatelet formation and rapidly-released platelets. Biotechnol Prog. 2017;: pubmed publisher
    ..We showed that modulating shear forces and flow patterns had an immediate and significant impact on PLP generation...
  34. Wang C, Deneen B, Tzeng S. MicroRNA-212 inhibits oligodendrocytes during maturation by down-regulation of differentiation-associated gene expression. J Neurochem. 2017;143:112-125 pubmed publisher
    ..the protein production of OLGs markers including 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNPase), MBP, and PLP. Additionally, mir-212 over-expression decreased the number of mature OLGs expressing MBP, and the expression of ..
  35. Dindo M, Conter C, Cellini B. Electrostatic interactions drive native-like aggregation of human alanine:glyoxylate aminostransferase. FEBS J. 2017;284:3739-3764 pubmed publisher
    ..the aggregation process of human peroxisomal alanine:glyoxylate aminotransferase (AGT), a pyridoxal 5'-phosphate (PLP)-dependent enzyme involved in glyoxylate detoxification...
  36. Wattiez R, Hermans C, Bernard A, Lesur O, Falmagne P. Human bronchoalveolar lavage fluid: two-dimensional gel electrophoresis, amino acid microsequencing and identification of major proteins. Electrophoresis. 1999;20:1634-45 pubmed
    ..The proteins in the lavage either are produced locally or originate from plasma. Two unknown proteins were identified and are currently under investigation. ..
  37. Accorsi A, Benatti S, Ross E, Nasi M, Malagoli D. A prokineticin-like protein responds to immune challenges in the gastropod pest Pomacea canaliculata. Dev Comp Immunol. 2017;72:37-43 pubmed publisher
    ..We have identified a prokineticin-like protein (PlP), that we called Pc-plp and we analyzed by real-time PCR (qPCR) its expression...
  38. Mareddy J, Suresh N, Kumar C, Kapavarapu R, Jayasree A, Pal S. 1,2,3-Triazole-nimesulide hybrid: Their design, synthesis and evaluation as potential anticancer agents. Bioorg Med Chem Lett. 2017;27:518-523 pubmed publisher
    ..They also inhibited PDE4B in vitro (60-70% at 10?M) that was supported by the docking studies (PLP score 87-94) in silico.
  39. Northrup L, Griffin J, Christopher M, Antunez L, Hartwell B, Pickens C, et al. Co-delivery of autoantigen and dexamethasone in incomplete Freund's adjuvant ameliorates experimental autoimmune encephalomyelitis. J Control Release. 2017;266:156-165 pubmed publisher
    ..In this work, dexamethasone was co-delivered with autoantigen (PLP) in vivo to create effective ASIT for the treatment of experimental autoimmune encephalomyelitis (EAE)...
  40. Ma Y, Chen H, Tzeng C. Low oxygen tension increases mitochondrial membrane potential and enhances expression of antioxidant genes and implantation protein of mouse blastocyst cultured in vitro. J Ovarian Res. 2017;10:47 pubmed publisher
    ..VEGF; glucose transporter 3, GLUT-3) and antioxidants (manganese superoxide dismutase, MnSOD; peroxiredoxin 5, PRDX5) were assessed using quantitative RT-PCR and implantation-related protein (Leukemia Inhibitory Factor Receptor, ..
  41. DeRatt B, Ralat M, Lysne V, Tayyari F, Dhar I, Edison A, et al. Metabolomic Evaluation of the Consequences of Plasma Cystathionine Elevation in Adults with Stable Angina Pectoris. J Nutr. 2017;147:1658-1668 pubmed publisher
    ..Most endogenously produced H2S is formed by pyridoxal phosphate (PLP)-dependent enzymes by noncanonical reactions of the transsulfuration pathway that yield H2S concurrently ..
  42. Yan W, Stone E, ZHANG Y. Structural Snapshots of an Engineered Cystathionine-?-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site. Biochemistry. 2017;56:876-885 pubmed publisher
    ..experiments pinpointed that a salt bridge between the phosphate of the essential cofactor pyridoxal 5'-phosphate (PLP) and residue R62 plays an important role in catalyzing ?- and ?-eliminations...
  43. Kropotov A, Gogvadze V, Shupliakov O, Tomilin N, Serikov V, Tomilin N, et al. Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells. Exp Cell Res. 2006;312:2806-15 pubmed
    ..The goal of our study was to determine the functional role of the novel antioxidant protein Peroxiredoxin V (PrxV), in protection of human lung carcinoma cell lines against apoptosis...
  44. Adiele R, Adiele C. Metabolic defects in multiple sclerosis. Mitochondrion. 2019;44:7-14 pubmed publisher
    ..Loss of myelin proteins including myelin basic protein (MBP), proteolipid protein (PLP), myelin associated glycoprotein (MAG), myelin oligodendrocyte glycoproetin (MOG), 2, 3,-cyclic nucleotide ..
  45. Rossignoli G, Phillips R, Astegno A, Menegazzi M, Voltattorni C, Bertoldi M. Phosphorylation of pyridoxal 5'-phosphate enzymes: an intriguing and neglected topic. Amino Acids. 2018;50:205-215 pubmed publisher
    Pyridoxal 5'-phosphate (PLP)-dependent enzymes catalyze a wide range of reactions of amino acids and amines, with the exception of glycogen phosphorylase which exhibits peculiar both substrate preference and chemical mechanism...
  46. Ho T, Huynh K, Nguyen D, Park H, Jung K, Sur B, et al. Catalytic Intermediate Crystal Structures of Cysteine Desulfurase from the Archaeon Thermococcus onnurineus NA1. Archaea. 2017;2017:5395293 pubmed publisher
    ..and cofactors including iron-sulfur cluster, is usually mobilized from cysteine by the pyridoxal 5'-phosphate- (PLP-) dependent enzyme of cysteine desulfurase (CDS)...
  47. van der Valk F, Schulte D, Meiler S, Tang J, Zheng K, Van den Bossche J, et al. Liposomal prednisolone promotes macrophage lipotoxicity in experimental atherosclerosis. Nanomedicine. 2016;12:1463-70 pubmed publisher
    ..Previously, we showed that liposomal nanoparticles loaded with prednisolone (LN-PLP) accumulated in plaque macrophages, however, induced proatherogenic effects in patients...
  48. Stolz L, Derouiche A, Devraj K, Weber F, Brunkhorst R, Foerch C. Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis. J Neuroinflammation. 2017;14:152 pubmed publisher
    ..Female SJL/J mice treated with anticoagulants namely warfarin or rivaroxaban were immunized with PLP139-151. Stable anticoagulation was maintained throughout the entire experiment...
  49. De Bellard M. Myelin in cartilaginous fish. Brain Res. 2016;1641:34-42 pubmed publisher
    ..And while they lack true proteolipid protein (PLP) like tetrapods, they express a DM-like protein in their myelin...
  50. Dai Y, Xing H, Song F, Yang Y, Qiu Z, Lu X, et al. Biotin-Conjugated Multilayer Poly [D,L-lactide-co-glycolide]-Lecithin-Polyethylene Glycol Nanoparticles for Targeted Delivery of Doxorubicin. J Pharm Sci. 2016;105:2949-2958 pubmed publisher
    ..studies, DOX-PLPB-NPs showed a higher DOX concentration than free DOX and DOX-PLGA-lecithin-PEG nanoparticles (DOX-PLP-NPs) in tumor site, especially in 24 h, and the lowest DOX level in normal organs...
  51. Mizobuchi T, Nonaka R, Yoshimura M, Abe K, Takahashi S, Kera Y, et al. Crystal structure of a pyridoxal 5'-phosphate-dependent aspartate racemase derived from the bivalve mollusc Scapharca broughtonii. Acta Crystallogr F Struct Biol Commun. 2017;73:651-656 pubmed publisher
    Aspartate racemase (AspR) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that is responsible for D-aspartate biosynthesis in vivo...
  52. Deka G, Bharath S, Savithri H, Murthy M. Structural studies on the decameric S. typhimurium arginine decarboxylase (ADC): Pyridoxal 5'-phosphate binding induces conformational changes. Biochem Biophys Res Commun. 2017;490:1362-1368 pubmed publisher
    ..5) due to the activation of inducible acid tolerance response (ATR) systems. The pyridoxal 5'-phosphate (PLP)-dependent enzyme, biodegradative arginine decarboxylase (ADC, encoded by AdiA), is a component of an ATR system...
  53. Van Der Eecken V, Clippe A, Dekoninck S, Goemaere J, Walbrecq G, Van Veldhoven P, et al. Abolition of peroxiredoxin-5 mitochondrial targeting during canid evolution. PLoS ONE. 2013;8:e72844 pubmed publisher
    In human, the subcellular targeting of peroxiredoxin-5 (PRDX5), a thioredoxin peroxidase, is dependent on the use of multiple alternative transcription start sites and two alternative in-frame translation initiation sites, which ..
  54. Rosenberg J, Ischebeck T, Commichau F. Vitamin B6 metabolism in microbes and approaches for fermentative production. Biotechnol Adv. 2017;35:31-40 pubmed publisher
    Vitamin B6 is a designation for the six vitamers pyridoxal, pyridoxine, pyridoxamine, pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate, and pyridoxamine...
  55. Leyens G, Donnay I, Knoops B. Cloning of bovine peroxiredoxins-gene expression in bovine tissues and amino acid sequence comparison with rat, mouse and primate peroxiredoxins. Comp Biochem Physiol B Biochem Mol Biol. 2003;136:943-55 pubmed
    ..the expression of the six PRDXs in bovine (Bos taurus), we first cloned cDNAs coding for PRDX1, PRDX2, PRDX4 and PRDX5. PRDX3 and PRDX6 had previously been cloned and characterized in bovine...
  56. Kropotov A, Grudinkin P, Pleskach N, Gavrilov B, Tomilin N, Zhivotovsky B. Downregulation of peroxiredoxin V stimulates formation of etoposide-induced double-strand DNA breaks. FEBS Lett. 2004;572:75-9 pubmed
    Antioxidant protein Peroxiredoxin V (PrxV) is located in mitochondria and peroxisomes but is also present in the nucleus...
  57. Vašek J, Hlásná Čepková P, Viehmannová I, Ocelák M, Cachique Huansi D, Vejl P. Dealing with AFLP genotyping errors to reveal genetic structure in Plukenetia volubilis (Euphorbiaceae) in the Peruvian Amazon. PLoS ONE. 2017;12:e0184259 pubmed publisher
    ..of genetic diversity, the degree of genotyping error was critical because descriptive parameters (He, FST, PLP 5%) varied substantially (by at least 25%). Due to low gene flow, P...
  58. Osorio M, Rowitch D, Tesar P, Wernig M, Windrem M, Goldman S. Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease. Stem Cells. 2017;35:311-315 pubmed publisher
    ..PMD may present as a connatal, classic and transitional forms, or as the less severe spastic paraplegia type 2 and PLP-null phenotypes...
  59. Banerjee M, Chakravarty D, Ballal A. Molecular basis of function and the unusual antioxidant activity of a cyanobacterial cysteine desulfurase. Biochem J. 2017;474:2435-2447 pubmed publisher
    ..The purified SufS protein existed as a pyridoxal 5' phosphate (PLP)-containing dimer with a relatively low desulfurase activity...
  60. Yuan J, Murrell G, Trickett A, Landtmeters M, Knoops B, Wang M. Overexpression of antioxidant enzyme peroxiredoxin 5 protects human tendon cells against apoptosis and loss of cellular function during oxidative stress. Biochim Biophys Acta. 2004;1693:37-45 pubmed
    Oxidative stress and apoptosis are implicated in tendon degeneration. Peroxiredoxin 5 (PRDX5) is a novel thioredoxin peroxidase recently identified in mammals, participating directly in eliminating hydrogen peroxide (H(2)O(2)) and ..
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    Proteolipid protein (PLP) is the most abundant integral membrane protein in compact central nervous system myelin, and null mutations of the PLP1 gene cause spastic paraplegia type 2 (SPG2)...
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    ..mitochondrial DNA (mtDNA) double-strand breaks (DSBs) were specifically induced in myelinating oligodendrocytes (PLP:mtPstI mice) by expressing a mitochondrial-targeted endonuclease, mtPstI, starting at 3 weeks of age...