Gene Symbol: PRDM6
Description: PR/SET domain 6
Alias: KMT8C, PDA3, PRISM, PR domain 6, PR domain containing 6, PR domain-containing protein 6, PR-domain zinc finger protein 6
Species: human
Products:     PRDM6

Top Publications

  1. Winterbottom E, Moroishi Y, Halchenko Y, Armstrong D, Beach P, Nguyen Q, et al. Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner. Environ Health. 2019;18:18 pubmed publisher
    ..inverse relationship between arsenic exposure and expression of the gene encoding the histone methyltransferase, PRDM6 (p < 0.001). Mutation of PRDM6 has been linked to the congenital heart defect, patent ductus arteriosus...
  2. Fellous A, Earley R, Silvestre F. The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene. 2019;687:173-187 pubmed publisher
    ..forty-eight Kmt orthologues (Ezh1, Ezh2, Setd2, Nsd1, Nsd2, Nsd3, Ash1l, Kmt2e, Setd5, Prdm1, Prdm2, Prdm4, Prdm5, Prdm6, Prdm8, Prdm9, Prdm10, Prdm11, Prdm12, Prdm13, Prdm14, Prdm15, Prdm16, Setd3, Setd4, Setd6, Setd1a, Setd1b, Kmt2a, ..
  3. Hadziselimovic F, Cathomas G, Verkauskas G, Dasevicius D, Stadler M. PRDM Histone Methyltransferase mRNA Levels Increase in Response to Curative Hormone Treatment for Cryptorchidism-Dependent Male Infertility. Genes (Basel). 2018;9: pubmed publisher
    ..We found there were lower levels of PRDM1, PRDM6, PRDM9, PRDM13, and PRDM14 mRNA in the testes of HIR patients compared with LIR patients, ..
  4. Rudolph A, Fasching P, Behrens S, Eilber U, Bolla M, Wang Q, et al. A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density. Breast Cancer Res. 2015;17:110 pubmed publisher
    ..genes (AKR1C4, CYP1A1-CYP1A2, CYP1B1, ESR2, PPARG, PRL, SULT1A1-SULT1A2 and TNF) and ten SNPs (AREG-rs10034692, PRDM6-rs186749, ESR1-rs12665607, ZNF365-rs10995190, 8p11...
  5. Davis C, Haberland M, Arnold M, Sutherland L, McDonald O, Richardson J, et al. PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Mol Cell Biol. 2006;26:2626-36 pubmed
    ..belonging to the PRDM (PRDI-BF1 and RIZ homology domain) family of chromatin-remodeling proteins and named it PRISM (PR domain in smooth muscle)...
  6. Lindstrom S, Thompson D, Paterson A, Li J, Gierach G, Scott C, et al. Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. Nat Commun. 2014;5:5303 pubmed publisher
    ..23) and percent density (PRDM6, 8p11.23 and TMEM184B)...
  7. Northcott P, Buchhalter I, Morrissy A, Hovestadt V, Weischenfeldt J, Ehrenberger T, et al. The whole-genome landscape of medulloblastoma subtypes. Nature. 2017;547:311-317 pubmed publisher, including hotspot in-frame insertions that target KBTBD4 and 'enhancer hijacking' events that activate PRDM6. Thus, the application of integrative genomics to an extensive cohort of clinical samples derived from a single ..
  8. Hong K, Lim J, Kim J, Tabara Y, Ueshima H, Miki T, et al. Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. Hum Mol Genet. 2014;23:6659-67 pubmed publisher
    ..Three novel loci were identified: rs2483280 (PRDM16 locus) and rs335206 (PRDM6 locus) were associated with QRS duration, and rs17026156 (SLC8A1 locus) correlated with PR interval...
  9. Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, et al. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. Am J Hum Genet. 2016;98:1082-1091 pubmed publisher
    ..combined genome-wide linkage analysis and whole-exome sequencing (WES), we identified independent mutations in PRDM6, which encodes a nuclear protein that is specific to vascular smooth muscle cells (VSMC), has histone methyl ..

More Information


  1. Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, et al. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. Am J Hum Genet. 2016;99:1000 pubmed publisher