PRDM14

Summary

Gene Symbol: PRDM14
Description: PR/SET domain 14
Alias: PFM11, PR domain zinc finger protein 14, PR domain 14, PR domain-containing 14, PR domain-containing protein 14
Species: human
Products:     PRDM14

Top Publications

  1. Nishikawa N, Toyota M, Suzuki H, Honma T, Fujikane T, Ohmura T, et al. Gene amplification and overexpression of PRDM14 in breast cancers. Cancer Res. 2007;67:9649-57 pubmed
    ..We found that PRDM14 mRNA is overexpressed in about two thirds of breast cancers; moreover, immunohistochemical analysis showed that ..
  2. Chia N, Chan Y, Feng B, Lu X, Orlov Y, Moreau D, et al. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature. 2010;468:316-20 pubmed publisher
    ..To understand the roles of these potential regulators of hESCs, we studied transcription factor PRDM14 to gain new insights into its functional roles in the regulation of pluripotency...
  3. Tsuneyoshi N, Sumi T, Onda H, Nojima H, Nakatsuji N, Suemori H. PRDM14 suppresses expression of differentiation marker genes in human embryonic stem cells. Biochem Biophys Res Commun. 2008;367:899-905 pubmed publisher
    b>PRDM14 was identified by microarray analysis and was expressed in specifically undifferentiated human ES cells...
  4. Liu B, Zhang S, Hui L, Qiu X, Cui Z. [Relationship between the expression of PRDM14 in non-small cell lung cancer and the clinicopathologic characteristics]. Zhongguo Fei Ai Za Zhi. 2010;13:867-72 pubmed publisher
    ..b>PRDM14 is a member of the PRDM family...
  5. Grigorash B, Suvorova I, Pospelov V. [AICAR-Dependent Activation of AMPK Kinase Is Not Accompanied by G1/S Block in Mouse Embryonic Stem Cells]. Mol Biol (Mosk). 2018;52:489-500 pubmed publisher
    ..which correlates with increased expression of pluripotency marker genes (OCT3/4, NANOG, SOX2, KLF4, ESRRB, PRDM14)...
  6. Rahman M, Islam T, Gov E, Turanli B, Gulfidan G, Shahjaman M, et al. Identification of Prognostic Biomarker Signatures and Candidate Drugs in Colorectal Cancer: Insights from Systems Biology Analysis. Medicina (Kaunas). 2019;55: pubmed publisher
    ..CENPN, MYC, and RFC2), 10 transcription factors (ETS1, ESR1, GATA1, GATA2, GATA3, AR, YBX1, FOXP3, E2F4, and PRDM14) and two microRNAs (miRNAs) (miR-193b-3p and miR-615-3p) were detected as reporter molecules...
  7. Kawaguchi M, Sugiyama K, Matsubara K, Lin C, Kuraku S, Hashimoto S, et al. Co-option of the PRDM14-CBFA2T complex from motor neurons to pluripotent cells during vertebrate evolution. Development. 2019;146: pubmed publisher
    ..PR domain-containing protein 14 (PRDM14) is specifically expressed in pluripotent cells and germ cells, and is required for establishing embryonic stem ..
  8. Fellous A, Earley R, Silvestre F. The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene. 2019;687:173-187 pubmed publisher
    ..Nsd2, Nsd3, Ash1l, Kmt2e, Setd5, Prdm1, Prdm2, Prdm4, Prdm5, Prdm6, Prdm8, Prdm9, Prdm10, Prdm11, Prdm12, Prdm13, Prdm14, Prdm15, Prdm16, Setd3, Setd4, Setd6, Setd1a, Setd1b, Kmt2a, Kmt2b, Kmt2c, Kmt2d, Kmt5a, Kmt5b, Ehmt1, Ehmt2, ..
  9. Bao S, Leitch H, Gillich A, Nichols J, Tang F, Kim S, et al. The germ cell determinant Blimp1 is not required for derivation of pluripotent stem cells. Cell Stem Cell. 2012;11:110-7 pubmed publisher
    Blimp1 (Prdm1), the key determinant of primordial germ cells (PGCs), plays a combinatorial role with Prdm14 during PGC specification from postimplantation epiblast cells...

More Information

Publications72

  1. Cheetham S, Gruhn W, van den Ameele J, Krautz R, Southall T, Kobayashi T, et al. Targeted DamID reveals differential binding of mammalian pluripotency factors. Development. 2018;145: pubmed publisher
    ..We mapped the binding sites of two key pluripotency factors, OCT4 and PRDM14, in mouse embryonic stem cells, epiblast-like cells and primordial germ cell-like cells (PGCLCs)...
  2. Di Micco R, Fontanals Cirera B, Low V, Ntziachristos P, Yuen S, Lovell C, et al. Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes. Cell Rep. 2014;9:234-47 pubmed publisher
    ..BRD4 maintains transcription of core stem cell genes such as OCT4 and PRDM14 by occupying their super-enhancers (SEs), large clusters of regulatory elements, and recruiting to them Mediator ..
  3. Li C, Lai W, Wang H. An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C. J Vis Exp. 2018;: pubmed publisher
    ..The mechanistic investigation shows that PD0325901 up-regulates Prdm14 expression to suppress Dnmt3b (de novo DNA methyltransferase) and Dnmt3l (the cofactor of Dnmt3b), by reducing de ..
  4. Fan L, Jiang J, Gao J, Song H, Liu J, Yang L, et al. Identification and Characterization of a PRDM14 Homolog in Japanese Flounder (Paralichthys olivaceus). Int J Mol Sci. 2015;16:9097-118 pubmed publisher
    b>PRDM14 is a PR (PRDI-BF1-RIZ1 homologous) domain protein with six zinc fingers and essential roles in genome-wide epigenetic reprogramming...
  5. Medrano J, Martínez Arroyo A, Míguez J, Moreno I, Martínez S, Quiñonero A, et al. Human somatic cells subjected to genetic induction with six germ line-related factors display meiotic germ cell-like features. Sci Rep. 2016;6:24956 pubmed publisher
    ..12 candidates that were reduced to 6, demonstrating that ectopic expression of the germ line-related genes PRDM1, PRDM14, LIN28A, DAZL, VASA and SYCP3 induced direct conversion of somatic cells (hFSK (46, XY), and hMSC (46, XY)) into a ..
  6. Ficz G, Hore T, Santos F, Lee H, Dean W, Arand J, et al. FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency. Cell Stem Cell. 2013;13:351-9 pubmed publisher
    ..We identify a Prdm14- and Nanog-binding cis-acting regulatory region in Dnmt3b that is highly responsive to signaling...
  7. Gillich A, Bao S, Grabole N, Hayashi K, Trotter M, Pasque V, et al. Epiblast stem cell-based system reveals reprogramming synergy of germline factors. Cell Stem Cell. 2012;10:425-39 pubmed publisher
    ..system could provide mechanistic insight on how the key determinants of primordial germ cells (PGCs), including Prdm14, induce reprogramming in germ cells to an epigenetic ground state...
  8. Taniguchi H, Imai K. PRDM14, a Zinc Finger Protein, Regulates Cancer Stemness. Methods Mol Biol. 2018;1867:3-13 pubmed publisher
    PRDI-BF1 and RIZ homology (PR) domain zinc finger protein 14 (PRDM14) contains a PR domain related to the SET methyltransferase domain and zinc finger motifs...
  9. Dalman A, Totonchi M, Rezazadeh Valojerdi M. Human Ovarian Theca-Derived Multipotent Stem Cells Have The Potential to Differentiate into Oocyte-Like Cells In Vitro. Cell J. 2019;20:527-536 pubmed publisher
    ..Gene expressions of PRDM1, PRDM14, VASA, DAZL, OCT4, ZP1, 2, 3 GDF9, SCP3 and DMC1 were evaluated by quantitative reverse transcription polymerase ..
  10. Hu X, Lu H, Cao S, Deng Y, Li Q, Wan Q, et al. Stem cells derived from human first-trimester umbilical cord have the potential to differentiate into oocyte-like cells in vitro. Int J Mol Med. 2015;35:1219-29 pubmed publisher
    ..4 (OCT4), stage-specific embryonic antigen 1 (SSEA1), B lymphocyte-induced maturation protein-1 (Blimp1), PR domain containing 14 (Prdm14), transcription factor AP-2 gamma (Tfap2C), VASA, STELLA, deleted in azoospermia-like (DAZL) and ..
  11. Pirouz M, Rahjouei A, Shamsi F, Eckermann K, Salinas Riester G, Pommerenke C, et al. Destabilization of pluripotency in the absence of Mad2l2. Cell Cycle. 2015;14:1596-610 pubmed publisher
    ..of pluripotency requires the expression of several core factors at appropriate levels (Oct4, Sox2, Klf4, Prdm14)...
  12. Hadziselimovic F, Cathomas G, Verkauskas G, Dasevicius D, Stadler M. PRDM Histone Methyltransferase mRNA Levels Increase in Response to Curative Hormone Treatment for Cryptorchidism-Dependent Male Infertility. Genes (Basel). 2018;9: pubmed publisher
    ..We found there were lower levels of PRDM1, PRDM6, PRDM9, PRDM13, and PRDM14 mRNA in the testes of HIR patients compared with LIR patients, and that PRDM7, PRDM9, PRDM12, ..
  13. Günesdogan U, Magnusdottir E, Surani M. Primordial germ cell specification: a context-dependent cellular differentiation event [corrected]. Philos Trans R Soc Lond B Biol Sci. 2014;369: pubmed publisher
    ..lineages, PGCs initiate a unique cellular programme driven by the cooperation of the transcription factors BLIMP1, PRDM14 and AP2γ...
  14. Kamikawa Y, Donohoe M. Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells. PLoS ONE. 2015;10:e0125626 pubmed publisher
    ..we show that the H3K27-specific demethylase Utx regulates the expression of the master regulators for XCI and XCR: Prdm14, Tsix, and Xist...
  15. Guttula P, Agarwal A, Maharana U, Gupta M. Prediction of novel pluripotent proteins involved in reprogramming of male Germline stem cells (GSCs) into multipotent adult Germline stem cells (maGSCs) by network analysis. Comput Biol Chem. 2018;76:302-309 pubmed publisher
    ..Phox2b, Nrp2, Dll1, Shh, Gbx2, Nodal, Lefty1, Wnt7b, Pitx2, fgf4, Pou5f1, Nanog, Tet1, trim8, alx2, Dppa2, Prdm14,Sox11, Esrrb were predicted to be involved in the stem cell development...
  16. Grabole N, Tischler J, Hackett J, Kim S, Tang F, Leitch H, et al. Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation. EMBO Rep. 2013;14:629-37 pubmed publisher
    ..Here we demonstrate that Prdm14 contributes not only to PGC specification, but also to naive pluripotency in embryonic stem (ES) cells by ..
  17. Leitch H, McEwen K, Turp A, Encheva V, Carroll T, Grabole N, et al. Naive pluripotency is associated with global DNA hypomethylation. Nat Struct Mol Biol. 2013;20:311-6 pubmed publisher
    ..This is driven by Prdm14 and is associated with downregulation of Dnmt3a and Dnmt3b...
  18. Wang H, Zhang K, Liu Y, Fu Y, Gao S, Gong P, et al. Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell. BMC Biol. 2017;15:114 pubmed publisher
    ..those with long telomere, hESCs with short telomeres exhibit the lowest expressions of TERF1/TRF1, and ZFP42/REX1, PRDM14 and NANOG markers for pluripotency, suggesting that these hESCs are prone to exit from the pluripotent state...
  19. Carofino B, Ayanga B, Justice M. A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech. 2013;6:1494-506 pubmed publisher
    b>PRDM14 functions in embryonic stem cell (ESC) maintenance to promote the expression of pluripotency-associated genes while suppressing differentiation genes...
  20. Zhao X, Cui L, Hao H, Wang H, Zhao S, Du W, et al. Transcriptome analyses of inner cell mass and trophectoderm cells isolated by magnetic-activated cell sorting from bovine blastocysts using single cell RNA-seq. Reprod Domest Anim. 2016;51:726-35 pubmed publisher
    ..to those of RNA-seq, including 12 novel ICM-dominant (HNF4A, CCL24, FGFR4, IFITM3, PTCHD2, GJB5, FN1, KLK7, PRDM14, GRP, FGF19 and GCM1) and two novel TE-dominant (SLC10A1 and WNT4) genes...
  21. Okashita N, Suwa Y, Nishimura O, Sakashita N, Kadota M, Nagamatsu G, et al. PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency. Stem Cell Reports. 2016;7:1072-1086 pubmed publisher
    ..from embryonic stem cells (ESCs) to elucidate the molecular and epigenetic functions of PR domain-containing 14 (PRDM14)...
  22. Murakami K, Günesdogan U, Zylicz J, Tang W, Sengupta R, Kobayashi T, et al. NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers. Nature. 2016;529:403-407 pubmed publisher
    ..bone morphogenetic protein 4 (BMP4), or ectopic expression of key germline transcription factors Prdm1, Prdm14 and Tfap2c, directly induce PGC-like cells (PGCLCs) in EpiLCs, but not in ES cells...
  23. Magnúsdóttir E, Dietmann S, Murakami K, Günesdogan U, Tang F, Bao S, et al. A tripartite transcription factor network regulates primordial germ cell specification in mice. Nat Cell Biol. 2013;15:905-15 pubmed publisher
    ..BLIMP1, the key regulator of primordial germ cell (PGC) specification, apparently acts together with PRDM14 and AP2γ...
  24. Aguilo F, Zakirova Z, Nolan K, Wagner R, Sharma R, Hogan M, et al. THAP1: Role in Mouse Embryonic Stem Cell Survival and Differentiation. Stem Cell Reports. 2017;9:92-107 pubmed publisher
    ..of THAP1 or replacement with a disease-causing mutation results in an enhanced rate of cell death, prolongs Nanog, Prdm14, and/or Rex1 expression upon differentiation, and results in failure to upregulate ectodermal genes...
  25. Kime C, Sakaki Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, et al. Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program. Proc Natl Acad Sci U S A. 2016;113:12478-12483 pubmed
    ..activator of transcription 3 (STAT3), which induces a previously unappreciated Kruppel-like factor (KLF)2-KLF4-PR domain 14 (PRDM14) transcription factor circuit key to establish naive pluripotency...
  26. Nettersheim D, Arndt I, Sharma R, Riesenberg S, Jostes S, Schneider S, et al. The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas. Br J Cancer. 2016;115:454-64 pubmed publisher
    ..cells left SOX17 levels unchanged, but resulted in downregulation of pluripotency- and PGC-related genes (LIN28, PRDM14, ZSCAN10), whereas somatic and germ cell differentiation markers were upregulated...
  27. Li C, Liu B, Zhong S, Wang H. MEK inhibitor PD0325901 and vitamin C synergistically induce hypomethylation of mouse embryonic stem cells. Oncotarget. 2016;7:39730-39739 pubmed publisher
    ..Our mechanistic study suggested that PD0325901 elevated expression of Prdm14, which repressed de novo methyltransferase Dnmt3b and its cofactor Dnmt3l at levels of protein, via the mode to ..
  28. Carofino B, Ayanga B, Tracey L, Brooke Bisschop T, Justice M. PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL. Biol Open. 2016;5:645-53 pubmed publisher
    b>PRDM14 is an epigenetic regulator known for maintaining embryonic stem cell identity and resetting potency in primordial germ cells...
  29. Shang M, Su B, Lipke E, Perera D, Li C, Qin Z, et al. Spermatogonial stem cells specific marker identification in channel catfish, Ictalurus punctatus and blue catfish, I. furcatus. Fish Physiol Biochem. 2015;41:1545-56 pubmed publisher
    ..In contrast to channel catfish, Id4, Smad5 and Prdm14 gene expressions were strongly down-regulated in spermatocyte cells, but up-regulated in spermatid cells in blue ..
  30. Huang X, Zhang R, Mao Y, Zhou L, Zhang C. Recent advances in molecular biology and treatment strategies for intracranial germ cell tumors. World J Pediatr. 2016;12:275-282 pubmed publisher
    ..endogenous brain cells; and findings in the molecular characterization of IGCTs suggest roles of CCND2, RB1, and PRDM14 in the pathogenesis of IGCTs and identify the KIT/RAS and AKT1/mTOR pathways as potential therapeutic targets in ..
  31. Iseki H, Nakachi Y, Hishida T, Yamashita Sugahara Y, Hirasaki M, Ueda A, et al. Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells. Stem Cells. 2016;34:322-33 pubmed publisher
    ..We further show that JARID2 physically interacts with ESRRB, SALL4A, and PRDM14, and that these JARID2-associated proteins synergistically and robustly facilitate iPSC reprogramming in a JARID2-..
  32. Draime A, Bridoux L, Belpaire M, Pringels T, Tys J, Rezsohazy R. PRDM14, a putative histone methyl-transferase, interacts with and decreases the stability and activity of the HOXA1 transcription factor. Biochim Biophys Acta Gene Regul Mech. 2018;1861:534-542 pubmed publisher
    ..In a recent screen for proteins interacting with HOXA1, we identified a PRDM protein family member, PRDM14, which is known to be transiently co-expressed with HOXA1 in epiblast cells before their specification towards ..
  33. Sim Y, Kim M, Nayfeh A, Yun Y, Kim S, Park K, et al. 2i Maintains a Naive Ground State in ESCs through Two Distinct Epigenetic Mechanisms. Stem Cell Reports. 2017;8:1312-1328 pubmed publisher
    ..Furthermore, 2i increased PRDM14 expression to inhibit DNMT3A/B protein expression by promoting G9a-mediated DNMT3A/B protein degradation...
  34. Okashita N, Sakashita N, Ito K, Mitsuya A, Suwa Y, Seki Y. PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation. Biochem Biophys Res Commun. 2015;466:138-45 pubmed publisher
    ..PR-domain containing transcriptional regulator 14 (PRDM14), is essential for maintenance of ESC self-renewal when the cells are cultured in serum plus LIF, but not in 2i ..
  35. Kitchen M, Bryan R, Emes R, Glossop J, Luscombe C, Cheng K, et al. Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer. Epigenetics. 2016;11:237-46 pubmed publisher
    ..similarly significant increases in mean levels of methylation in high-grade tumors for the ATP5G2, VAX2, INSRR, PRDM14, VSX1, TFAP2b, PRRX1, and HIST1H4F genes (P<0.05)...
  36. Lee S, Huang K. Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia. BMC Med Genomics. 2016;9:68 pubmed publisher
    ..SDMN, there are 10 hypermethylated SDMGs, including GNA13, CAPNS1, GABPB2, GIT2, LEFTY1, NDUFA10, MIOS, MPHOSPH6, PRDM14 and RFWD2...
  37. Eslami Arshaghi T, Vakilian S, Seyedjafari E, Ardeshirylajimi A, Soleimani M, Salehi M. Primordial germ cell differentiation of nuclear transfer embryonic stem cells using surface modified electroconductive scaffolds. In Vitro Cell Dev Biol Anim. 2017;53:371-380 pubmed publisher
    ..The nanofiber topography notably upregulated the expressions of prdm14, mvh and c-kit compared with tissue culture polystyrene (TCP)...
  38. Nady N, Gupta A, Ma Z, Swigut T, Koide A, Koide S, et al. ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation. elife. 2015;4:e10150 pubmed publisher
    b>Prdm14 is a sequence-specific transcriptional regulator of embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation...
  39. Gell J, Zhao J, Chen D, Hunt T, Clark A. PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation. Stem Cell Res. 2018;27:46-56 pubmed publisher
    ..One recently identified susceptibility loci for human GCT is PR (PRDI-BF1 and RIZ) domain proteins 14 (PRDM14). PRDM14 is expressed in early primate PGCs and is repressed as PGCs differentiate...
  40. Dahle Ã, Kuehn M. Inhibiting Smad2/3 signaling in pluripotent mouse embryonic stem cells enhances endoderm formation by increasing transcriptional priming of lineage-specifying target genes. Dev Dyn. 2016;245:807-15 pubmed publisher
    ..immunoprecipitation-deep sequencing of undifferentiated mouse ESCs inhibited for Smad2/3 signaling identified Prdm14, important for protecting pluripotency, as a target gene...
  41. Wei Y, Fang J, Cai S, Lv C, Zhang S, Hua J. Primordial germ cell-like cells derived from canine adipose mesenchymal stem cells. Cell Prolif. 2016;49:503-11 pubmed publisher
    ..and male germ-like cells, which were positive for PR domain-containing 1 (Prdm1), PR domain-containing 14 (Prdm14), doublesex and mab-3 related transcription factor (Dmrt1), as well as for promyelocytic leukaemia zinc finger (..
  42. Heltemes Harris L, Larson J, Starr T, Hubbard G, Sarver A, Largaespada D, et al. Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia. Oncogene. 2016;35:3454-64 pubmed publisher
    ..frequently targeted by the T2/Onc transposon; these included Sos1 (74%), Kdm2a (35%), Jak1 (26%), Bmi1 (19%), Prdm14 or Ncoa2 (13%), Cdkn2a (10%), Ikzf1 (8%), Caap1 (6%) and Klf3 (6%)...
  43. Chou Y, Yang M. Epithelial-mesenchymal transition-related factors in solid tumor and hematological malignancy. J Chin Med Assoc. 2015;78:438-45 pubmed publisher
    ..EMT regulators including Snail, Zeb1, Zeb2, and Twist in solid tumor and Sox4, distal-less homeobox gene 4 (DLX4), Prdm14, Bmi1, and the forkhead box family in hematological malignancy are reviewed with regard to their signaling ..
  44. Rzehak P, Covic M, Saffery R, Reischl E, Wahl S, Grote V, et al. DNA-Methylation and Body Composition in Preschool Children: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP)-Study. Sci Rep. 2017;7:14349 pubmed publisher
    ..Probes in genes SNED1(IRE-BP1), KLHL6, WDR51A(POC1A), CYTH4-ELFN2, CFLAR, PRDM14, SOS1, ZNF643(ZFP69B), ST6GAL1, C3orf70, CILP2, MLLT4 and ncRNA LOC101929268 remained significantly associated ..
  45. Dong G, Shang Z, Liu L, Liu C, Ge Y, Wang Q, et al. Retinoic acid combined with spermatogonial stem cell conditions facilitate the generation of mouse germ-like cells. Biosci Rep. 2017;37: pubmed publisher
    ..cells, as shown by the activation of spermatogenesis-associated genes such as Mvh, Dazl, Prdm14, Stella, Scp1, Scp3, Stra8 and Rec8 In contrast, for cells cultured in ..
  46. Nandy S, Orozco A, Lopez Valdez R, Roberts R, Subramani R, Arumugam A, et al. Glucose insult elicits hyperactivation of cancer stem cells through miR-424-cdc42-prdm14 signalling axis. Br J Cancer. 2017;117:1665-1675 pubmed publisher
    ..Cdc42, a target of miR-424, influences cancer stem cell activity by positively regulating prdm14 through activation of pak1 (p-21-activated kinase 1) and stat5...
  47. Jiang G, Huang S. The yin-yang of PR-domain family genes in tumorigenesis. Histol Histopathol. 2000;15:109-17 pubmed publisher
    ..This imbalance in the amount of the two products, a result of either genetic or epigenetic events, appears to be an important cause of malignancy. ..
  48. Sugawa F, Araúzo Bravo M, Yoon J, Kim K, Aramaki S, Wu G, et al. Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile. EMBO J. 2015;34:1009-24 pubmed publisher
    ..differentiate first into a heterogeneous mesoderm-like cell population and then into PGCLCs, which exhibit minimal PRDM14 expression...
  49. Han Y, Lin Q. [Research Progress of PR Domain Zinc Finger Protein 14]. Zhongguo Fei Ai Za Zhi. 2016;19:93-7 pubmed publisher
    b>PR domain zinc finger protein 14 (PRDM14) is an important member of the PRDM family, PRDM14 plays a key role in the maintenance of cell integrity and differentiation, growth and apoptosis of the cell...
  50. Snellenberg S, Cillessen S, Van Criekinge W, Bosch L, Meijer C, Snijders P, et al. Methylation-mediated repression of PRDM14 contributes to apoptosis evasion in HPV-positive cancers. Carcinogenesis. 2014;35:2611-8 pubmed publisher
    Promoter methylation of the transcription factor PRDM14 (PRDI-BF1 and RIZ domain containing 14) represents a highly frequent event in human papillomavirus (HPV)-induced cervical cancers and cancer precursor lesions...
  51. Ruark E, Seal S, McDonald H, Zhang F, Elliot A, Lau K, et al. Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. Nat Genet. 2013;45:686-9 pubmed publisher
    ..The loci include genes plausibly related to TGCT development. PRDM14, at 8q13.3, is essential for early germ cell specification, and DAZL, at 3p24...
  52. Tu S, Narendra V, Yamaji M, Vidal S, Rojas L, Wang X, et al. Co-repressor CBFA2T2 regulates pluripotency and germline development. Nature. 2016;534:387-90 pubmed publisher
    ..factors in common with embryonic stem (ES) cells, including OCT4 (encoded by Pou5f1), SOX2, NANOG and PRDM14 (refs 2, 3, 4)...
  53. Mzoughi S, Zhang J, Hequet D, Teo S, Fang H, Xing Q, et al. PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling. Nat Genet. 2017;49:1354-1363 pubmed publisher
    ..Here we characterize the transcriptional regulator PRDM15, which acts independently of PRDM14 to regulate the naive state of mouse ESCs...
  54. Zhang T, Meng L, Dong W, Shen H, Zhang S, Liu Q, et al. High expression of PRDM14 correlates with cell differentiation and is a novel prognostic marker in resected non-small cell lung cancer. Med Oncol. 2013;30:605 pubmed publisher
    ..The objectives of this study were to determine the frequency and prognostic significance of PRDM1 and PRDM14 expression in a cohort of surgically resected non-small cell lung cancer (NSCLC) patients...
  55. Shirane K, Kurimoto K, Yabuta Y, Yamaji M, Satoh J, Ito S, et al. Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells. Dev Cell. 2016;39:87-103 pubmed publisher
    ..Loss of PRDM14 globally upregulates methylation and diminishes the hypomethylated domains, but it preserves demethylation-..
  56. Burton A, Torres Padilla M. A Pluripotency Platform for Prdm14. Dev Cell. 2016;38:3-5 pubmed publisher
    The tripartite network of Prdm14, Blimp1, and AP2? is essential for the important process of germ cell specification, but their precise molecular mechanisms of action remain lacking...
  57. Moriya C, Taniguchi H, Nagatoishi S, Igarashi H, Tsumoto K, Imai K. PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78. Cancer Sci. 2018;109:373-383 pubmed publisher
    b>PRDM14 is overexpressed in various cancers and can regulate cancer phenotype under certain conditions...
  58. Werner R, Schultz B, Huhn J, Jelinek J, Madzo J, Engel N. Sex chromosomes drive gene expression and regulatory dimorphisms in mouse embryonic stem cells. Biol Sex Differ. 2017;8:28 pubmed publisher
    ..We showed differential Prdm14-responsive enhancer activity in male and female cells, correlating with the sex-specific levels of Prdm14 ..
  59. Moriya C, Taniguchi H, Miyata K, Nishiyama N, Kataoka K, Imai K. Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice. Carcinogenesis. 2017;38:638-648 pubmed publisher
    ..Cancer stem cells are considered to be responsible for these properties. PRDM14, a transcriptional regulator that maintains pluripotency in embryonic stem cells, is overexpressed in some cancers...
  60. Taniguchi H, Hoshino D, Moriya C, Zembutsu H, Nishiyama N, Yamamoto H, et al. Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer. Oncotarget. 2017;8:46856-46874 pubmed publisher
    b>PR domain zinc finger protein 14 (PRDM14) maintains stemness in embryonic stem cells via epigenetic mechanisms...
  61. Lu Y, Wan Z, Zhang X, Zhong X, Rui L, Li Z. PRDM14 inhibits 293T cell proliferation by influencing the G1/S phase transition. Gene. 2016;595:180-186 pubmed publisher
    b>PRDM14 (PRDI-BF1 and RIZ domain-containing 14), a transcription factor, plays important roles in primordial germ cell specification and embryonic stem cell pluripotency, and supports the maintenance of self-renewal by promoting the ..
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