PRDM1

Summary

Gene Symbol: PRDM1
Description: PR/SET domain 1
Alias: BLIMP1, PRDI-BF1, PR domain zinc finger protein 1, B-lymphocyte-induced maturation protein 1, BLIMP-1, PR domain 1, PR domain containing 1, with ZNF domain, PRDI-binding factor-1, beta-interferon gene positive-regulatory domain I binding factor
Species: human
Products:     PRDM1

Top Publications

  1. Best T, Li D, Skol A, Kirchhoff T, Jackson S, Yasui Y, et al. Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma. Nat Med. 2011;17:941-3 pubmed publisher
    ..The variants comprise a risk locus associated with decreased basal expression of PRDM1 (encoding PR domain containing 1, with ZNF domain) and impaired induction of the PRDM1 protein after radiation ..
  2. Su S, Ying H, Chiu Y, Lin F, Chen M, Lin K. Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. Mol Cell Biol. 2009;29:1421-31 pubmed publisher
    ..These findings provide further insights into the molecular mechanism of the silencing of mature B-cell genes by Blimp-1 in plasma cell differentiation. ..
  3. Vasanwala F, Kusam S, Toney L, Dent A. Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene. J Immunol. 2002;169:1922-9 pubmed
    ..Repression of AP-1 function by BCL-6 may be a key mechanism for how BCL-6 regulates gene expression to control inflammation, lymphocyte differentiation, and lymphomagenesis. ..
  4. Morgan M, Mould A, Li L, Robertson E, Bikoff E. Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions. Mol Cell Biol. 2012;32:3403-13 pubmed publisher
    b>Prdm1/Blimp-1 is a master regulator of gene expression in diverse tissues of the developing embryo and adult organism...
  5. Smith M, Maurin M, Cho H, Becknell B, Freud A, Yu J, et al. PRDM1/Blimp-1 controls effector cytokine production in human NK cells. J Immunol. 2010;185:6058-67 pubmed publisher
    ..In this report, we demonstrate that the transcriptional repressor PRDM1 (also known as Blimp-1 or PRDI-BF1) is a critical negative regulator of NK function...
  6. Yan J, Jiang J, Lim C, Wu Q, Ng H, Chin K. BLIMP1 regulates cell growth through repression of p53 transcription. Proc Natl Acad Sci U S A. 2007;104:1841-6 pubmed
    Tight regulation of p53 is essential for maintaining normal cell growth. Here we report that BLIMP1 acts in an autoregulatory feedback loop that controls p53 activity through repression of p53 transcription...
  7. Keller A, Maniatis T. Identification and characterization of a novel repressor of beta-interferon gene expression. Genes Dev. 1991;5:868-79 pubmed
  8. Gyory I, Wu J, Fejer G, Seto E, Wright K. PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing. Nat Immunol. 2004;5:299-308 pubmed
    ..This establishes a mechanism for the recruitment of G9a, the main mammalian euchromatic methyltransferase, and defines nonembryonic targets of G9a. ..
  9. Smith M, Wright G, Wu J, Tailor P, Ozato K, Chen X, et al. Positive regulatory domain I (PRDM1) and IRF8/PU.1 counter-regulate MHC class II transactivator (CIITA) expression during dendritic cell maturation. J Biol Chem. 2011;286:7893-904 pubmed publisher
    ..reveals that DC maturation induces complete disassociation of the bound activators paralleled by recruitment of PRDM1/Blimp-1 to the promoter...

More Information

Publications91

  1. Vrzalikova K, Vockerodt M, Leonard S, Bell A, Wei W, Schrader A, et al. Down-regulation of BLIMP1? by the EBV oncogene, LMP-1, disrupts the plasma cell differentiation program and prevents viral replication in B cells: implications for the pathogenesis of EBV-associated B-cell lymphomas. Blood. 2011;117:5907-17 pubmed publisher
    ..We focused on BLIMP1?, a transcription factor that is required for plasma cell differentiation and that is inactivated in diffuse large ..
  2. Julaton V, Reijo Pera R. NANOS3 function in human germ cell development. Hum Mol Genet. 2011;20:2238-50 pubmed publisher
    ..Findings may contribute to our understanding of the basic biology of human germ cell development and may provide clinical insights regarding infertility. ..
  3. Iqbal J, Kucuk C, Deleeuw R, Srivastava G, Tam W, Geng H, et al. Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Leukemia. 2009;23:1139-51 pubmed publisher
    ..The minimal common region of deletion in 6q21 included three known genes (PRDM1, ATG5 and AIM1) showing generally low expression...
  4. Shaffer A, Lin K, Kuo T, Yu X, Hurt E, Rosenwald A, et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity. 2002;17:51-62 pubmed
  5. Desai S, Bolick S, Maurin M, Wright K. PU.1 regulates positive regulatory domain I-binding factor 1/Blimp-1 transcription in lymphoma cells. J Immunol. 2009;183:5778-87 pubmed publisher
    ..However, little is currently known about the regulation of PRDM1, the gene encoding PRDI-BF1...
  6. Garcia J, Roncador G, Garcia J, Sánz A, Maestre L, Lucas E, et al. PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma. Haematologica. 2006;91:467-74 pubmed
    The positive regulatory domain I (PRDM1) protein or BLIMP-1, belonging to the PRDM gene family of transcriptional repressors, is a key regulator of terminal differentiation in B-lymphocytes and is critical for plasma cell differentiation...
  7. Wang X, Belguise K, O Neill C, Sánchez Morgan N, Romagnoli M, Eddy S, et al. RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1. Mol Cell Biol. 2009;29:3832-44 pubmed publisher
    ..Specifically, RelB is shown for the first time to induce expression of the zinc finger repressor protein Blimp1 (B-lymphocyte-induced maturation protein), the critical mediator of B- and T-cell development, which is ..
  8. Ancelin K, Lange U, Hajkova P, Schneider R, Bannister A, Kouzarides T, et al. Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. Nat Cell Biol. 2006;8:623-30 pubmed
    b>Blimp1, a transcriptional repressor, has a crucial role in the specification of primordial germ cells (PGCs) in mice at embryonic day 7.5 (E7.5)...
  9. Ren B, Chee K, Kim T, Maniatis T. PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Genes Dev. 1999;13:125-37 pubmed
    ..We conclude that PRDI-BF1/Blimp-1 represses transcription by recruiting a complex of Groucho family proteins to DNA, and suggest that such corepressor complexes are required for the postinduction repression of the IFN-beta promoter. ..
  10. Angelin Duclos C, Cattoretti G, Lin K, Calame K. Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo. J Immunol. 2000;165:5462-71 pubmed
    ..Together, these data support a model in which B cell fate decisions occur within the germinal center and Blimp-1 expression is critical for commitment to a plasma cell, rather than a memory cell, fate. ..
  11. Desai S, Maurin M, Smith M, Bolick S, Dessureault S, Tao J, et al. PRDM1 is required for mantle cell lymphoma response to bortezomib. Mol Cancer Res. 2010;8:907-18 pubmed publisher
    ..This report establishes a requirement for the transcription repressor PR domain zinc finger protein 1 (PRDM1, Blimp1) in the response to bortezomib...
  12. Turner C, Mack D, Davis M. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell. 1994;77:297-306 pubmed
    ..Thus, Blimp-1 appears to be a pleiotropic regulatory factor capable of at least partially driving the terminal differentiation of B cells. ..
  13. Kucuk C, Iqbal J, Hu X, Gaulard P, de Leval L, Srivastava G, et al. PRDM1 is a tumor suppressor gene in natural killer cell malignancies. Proc Natl Acad Sci U S A. 2011;108:20119-24 pubmed publisher
    ..Here we show that PRDM1 is a tumor suppressor gene in NKCLs that is inactivated by a combination of monoallelic deletion and promoter CpG ..
  14. Schmidt D, Nayak A, Schumann J, Schimpl A, Berberich I, Berberich Siebelt F. Blimp-1Deltaexon7: a naturally occurring Blimp-1 deletion mutant with auto-regulatory potential. Exp Cell Res. 2008;314:3614-27 pubmed publisher
    ..This is in agreement with our finding that Blimp-1Delta7 interferes with endogenous Blimp-1 expression. Thus, our data suggest an auto-regulatory mechanism of Blimp-1 activation. ..
  15. Pasqualucci L, Compagno M, Houldsworth J, Monti S, Grunn A, Nandula S, et al. Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. J Exp Med. 2006;203:311-7 pubmed
    PR domain containing 1 with zinc finger domain (PRDM1)/B lymphocyte-induced maturation protein 1 (BLIMP1) is a transcriptional repressor expressed in a subset of germinal center (GC) B cells and in all plasma cells, and required for ..
  16. Karube K, Nakagawa M, Tsuzuki S, Takeuchi I, Honma K, Nakashima Y, et al. Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses. Blood. 2011;118:3195-204 pubmed publisher
    ..One of these regions included POPDC3, PREP, PRDM1, ATG5, and AIM1, whereas the other included LACE1 and FOXO3...
  17. Gyory I, Fejer G, Ghosh N, Seto E, Wright K. Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines. J Immunol. 2003;170:3125-33 pubmed
    ..into a plasma cell requires expression of the positive regulatory domain zinc finger protein 1 gene (PRDM1) that encodes the positive regulatory domain I binding factor 1 (PRDI-BF1 or Blimp-1) protein...
  18. Yu J, Angelin Duclos C, Greenwood J, Liao J, Calame K. Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. Mol Cell Biol. 2000;20:2592-603 pubmed
    ..Second, a chromatin immunoprecipitation assay shows that expression of Blimp-1 causes deacetylation of histone H3 associated with the c-myc promoter, and this deacetylation depends on the Blimp-1 binding site in the c-myc promoter. ..
  19. Nie K, Gomez M, Landgraf P, Garcia J, Liu Y, Tan L, et al. MicroRNA-mediated down-regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg cells: a potential pathogenetic lesion in Hodgkin lymphomas. Am J Pathol. 2008;173:242-52 pubmed publisher
    b>PRDM1/Blimp-1, a master regulator in terminal B-cell differentiation, has been recently identified as a tumor suppressor target for mutational inactivation in diffuse large B-cell lymphomas of the activated B-cell type...
  20. MARTINS G, Calame K. Regulation and functions of Blimp-1 in T and B lymphocytes. Annu Rev Immunol. 2008;26:133-69 pubmed publisher
    ..In spite of some commonalities, different targets and regulators of Blimp-1 in B and T cells suggest intriguing evolutionary divergence of this regulatory machinery. ..
  21. van Hamburg J, Tas S. Molecular mechanisms underpinning T helper 17 cell heterogeneity and functions in rheumatoid arthritis. J Autoimmun. 2018;87:69-81 pubmed publisher
    ..factors for RA including CCR6, CD226, CSF2, EOMES, ETS1, GATA3, IL2, IL6R, IL23R, IKZF3, IRAK1, IRF4, IRF8, PRKCQ, PRDM1, RBPJ, RUNX1 and TAGAP are directly involved in Th17 cell differentiation and/or function...
  22. Fan L, Jiang J, Gao J, Song H, Liu J, Yang L, et al. Identification and Characterization of a PRDM14 Homolog in Japanese Flounder (Paralichthys olivaceus). Int J Mol Sci. 2015;16:9097-118 pubmed publisher
    ..We also presume that the Po-prdm14 transcription factor binding sites and their conserved binding region among vertebrates. The combined results suggest that Po-PRDM14 has a conserved function in teleosts and mammals. ..
  23. Martins K, Hagedorn B, Ali S, Kennish J, Applegate B, Leu M, et al. Tissue Phthalate Levels Correlate With Changes in Immune Gene Expression in a Population of Juvenile Wild Salmon. Arch Environ Contam Toxicol. 2016;71:35-47 pubmed publisher
    ..dimethyl phthalate expressed significantly fewer secreted and membrane-bound immunoglobulin heavy-chain mu and Blimp1 transcripts in their hematopoietic tissue...
  24. Arevalo Sureda E, Weström B, Pierzynowski S, Prykhodko O. Maturation of the Intestinal Epithelial Barrier in Neonatal Rats Coincides with Decreased FcRn Expression, Replacement of Vacuolated Enterocytes and Changed Blimp-1 Expression. PLoS ONE. 2016;11:e0164775 pubmed publisher
    ..The changes in expression of Blimp-1 in the distal SI epithelium followed the maturation pattern. ..
  25. Chen H, Gilbert C, Hudson J, Bolick S, Wright K, Piskurich J. Positive regulatory domain I-binding factor 1 mediates repression of the MHC class II transactivator (CIITA) type IV promoter. Mol Immunol. 2007;44:1461-70 pubmed
    ..These findings demonstrate for the first time that, in addition to silencing expression of CIITA pIII in B lymphocytes, PRDI-BF1 is capable of binding and suppressing CIITA pIV. ..
  26. Giltiay N, Shu G, Shock A, Clark E. Targeting CD22 with the monoclonal antibody epratuzumab modulates human B-cell maturation and cytokine production in response to Toll-like receptor 7 (TLR7) and B-cell receptor (BCR) signaling. Arthritis Res Ther. 2017;19:91 pubmed publisher
    ..Emab can both regulate cytokine expression and block Blimp1-dependent B-cell differentiation, although the effects of Emab may depend on the stage of B-cell development or ..
  27. Xia Y, Xu Monette Z, Tzankov A, Li X, Manyam G, Murty V, et al. Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma. Leukemia. 2017;31:625-636 pubmed publisher
    b>PRDM1/BLIMP-1, a master regulator of plasma-cell differentiation, is frequently inactivated in activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) patients...
  28. Eckert D, Biermann K, Nettersheim D, Gillis A, Steger K, Jack H, et al. Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors. BMC Dev Biol. 2008;8:106 pubmed publisher
    ..In murine PGCs, expression and interaction of Blimp1 and Prmt5 results in arginine 3 dimethylation of histone H2A and H4...
  29. Nawandar D, Wang A, Makielski K, Lee D, Ma S, Barlow E, et al. Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. PLoS Pathog. 2015;11:e1005195 pubmed publisher
    ..cell lines, and that the combination of KLF4 and another differentiation-dependent cellular transcription factor, BLIMP1, is highly synergistic for inducing lytic EBV infection...
  30. Montes Moreno S, Martinez Magunacelaya N, Zecchini Barrese T, Villambrosía S, Linares E, Ranchal T, et al. Plasmablastic lymphoma phenotype is determined by genetic alterations in MYC and PRDM1. Mod Pathol. 2017;30:85-94 pubmed publisher
    ..translocations were PRDM1-mutated), but not restricted to those cases, and lead to expression of an impaired PRDM1/Blimp1? protein...
  31. Fu S, Yeh L, Chu C, Yen B, Sytwu H. New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function. J Biomed Sci. 2017;24:49 pubmed publisher
  32. Wang Y, Zhou J, Zhang Y, Wang L, Liu Y, Fan L, et al. PRDM1 expression on the epithelial component but not on ectopic lymphoid tissues of Warthin tumour. Oral Dis. 2015;21:432-6 pubmed publisher
    To determine the role of PRDM1, a key molecule for modulating the immune cells, in Warthin tumour (WT) pathogenesis. Forty paraffin-embedded parotid tissues of patients (mean age: 62.08 ± 11...
  33. Zhang X, Ma Z, Cui W, Pang X, Chen R, Wang L, et al. [Impact of PRDM1 gene inactivation on C-MYC regulation in diffuse large B-cell lymphoma]. Zhonghua Bing Li Xue Za Zhi. 2018;47:25-31 pubmed publisher
    ..Immunohistochemical methods were used to detect the expression of CD20, CD10, MUM1, Ki-67, bcl-6, PRDM1/Blimp1, C-MYC and PAX5 protein. The tumors were classified into two subtypes according to Hans classification...
  34. Yoon H, Scharer C, Majumder P, Davis C, Butler R, Zinzow Kramer W, et al. ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells. J Immunol. 2012;189:2393-403 pubmed publisher
    ..These results introduce ZBTB32 as a novel regulator of MHC-II gene expression and a potential regulatory partner of Blimp-1 in repressing gene expression. ..
  35. Kim K, Kim T, Ihn H, Kim J, Choi J, Shin H, et al. Inhibitory Effect of Purpurogallin on Osteoclast Differentiation in Vitro through the Downregulation of c-Fos and NFATc1. Int J Mol Sci. 2018;19: pubmed publisher
    ..Purpurogallin also significantly reduced the expression level of B lymphocyte-induced maturation protein-1 (Blimp1) gene (Prdm1)...
  36. Leucci E, Onnis A, Cocco M, De Falco G, Imperatore F, Giuseppina A, et al. B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA-altered expression. Int J Cancer. 2010;126:1316-26 pubmed publisher
    ..evidence that hsa-miR-127 is involved in B-cell differentiation process through posttranscriptional regulation of BLIMP1 and XBP1...
  37. Nance J, Bélanger S, Johnston R, Hu J, Takemori T, Crotty S. Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3. Proc Natl Acad Sci U S A. 2015;112:13324-9 pubmed publisher
    ..b>Blimp1 (Prdm1) is a potent inhibitor of Tfh cell differentiation...
  38. Zhu Z, Wang H, Wei Y, Meng F, Liu Z, Zhang Z. Downregulation of PRDM1 promotes cellular invasion and lung cancer metastasis. Tumour Biol. 2017;39:1010428317695929 pubmed publisher
    The zinc-finger transcription factor PRDM1 (PR domain containing 1) plays key roles in the development of malignant lymphoma, leukaemia and some non-haematopoietic cancers, including breast cancer, colorectal cancer and glioma...
  39. Sacco A, Kawano Y, Moschetta M, Zavidij O, Huynh D, Reagan M, et al. A novel in vivo model for studying conditional dual loss of BLIMP-1 and p53 in B-cells, leading to tumor transformation. Am J Hematol. 2017;92:E138-E145 pubmed publisher
    ..This model mirrors what reported in patients with ABC DLBLC, and therefore represents a novel model for studying the biology of ABC-DLBCL harboring the dual loss of BLIMP-1/p53 and c-Myc over-expression. ..
  40. Tam W, Gomez M, Chadburn A, Lee J, Chan W, Knowles D. Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas. Blood. 2006;107:4090-100 pubmed
    The PR (PRDI-BF1-RIZ) domain zinc finger protein 1 (PRDM1) is a transcription repressor with a pivotal role in plasma-cell differentiation...
  41. Xie M, Koh B, Hollister K, Wu H, Sun J, Kaplan M, et al. Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice. Eur J Immunol. 2017;47:1136-1141 pubmed publisher
    The transcription factors Bcl6 and Blimp1 have opposing roles in the development of the follicular helper T (TFH ) cells: Bcl6 promotes and Blimp1 inhibits TFH -cell differentiation...
  42. Huang X, Zhou X, Wang Z, Li F, Liu F, Zhong L, et al. CD99 triggers upregulation of miR-9-modulated PRDM1/BLIMP1 in Hodgkin/Reed-Sternberg cells and induces redifferentiation. Int J Cancer. 2012;131:E382-94 pubmed publisher
    ..lines and primary cHL cases correlates with the deficient expression of the positive regulatory domain 1 (PRDM1/BLIMP1). In addition, cHL cell lines showed high levels of miR-9 expression...
  43. Song Y, Cao Z, Li L, Zhang H, Zhang X. Blimp-1 protein and Hans classification on prognosis of diffuse large B-cell lymphoma and their interrelation. Chin J Cancer. 2010;29:781-6 pubmed
    ..The patients with GCB subtype of DLBCL had better prognosis than the non-GCB subtype. High level of Blimp-1 expression in the patients with DLBCL implies a shorter survival, but it is not associated with Hans classification. ..
  44. Jain R, Chen Y, Kanno Y, Joyce Shaikh B, Vahedi G, Hirahara K, et al. Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells. Immunity. 2016;44:131-142 pubmed publisher
    ..We identified the transcription factor Blimp-1 (Prdm1) as a key IL-23-induced factor that drove the inflammatory function of Th17 cells...
  45. Liu C, Liu W, Fan L, Liu J, Li P, Zhang W, et al. Sequences analyses and expression profiles in tissues and embryos of Japanese flounder (Paralichthys olivaceus) PRDM1. Fish Physiol Biochem. 2016;42:467-82 pubmed publisher
    b>PRDM1 (PRDI-BF1-RIZ1 homologous domain containing 1) appears to be a pleiotropic regulatory factor in various processes. It contains a PR (PRDI-BF1-RIZ1 homologous) domain protein and five zinc fingers...
  46. Kim G, Das R, Goduni L, McClellan S, Hazlett L, Mahabeleshwar G. Kruppel-like Factor 6 Promotes Macrophage-mediated Inflammation by Suppressing B Cell Leukemia/Lymphoma 6 Expression. J Biol Chem. 2016;291:21271-21282 pubmed
    ..level, KLF6 suppresses BCL6 mRNA and protein expression by elevating PR domain-containing 1 with ZNF domain (PRDM1) levels in macrophages...
  47. Liu G, Wang J, Chu Z, Yu Y, Zhou W. [Effect of B Lymphocyte-Induced Mature Protein-1 Expression in Bone Marrow Mononuclear Cells on Prognosis of Patients with Multiple Myeloma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1449-1453 pubmed publisher
    To study the effect of B lymphocyte-induced mature protein-1(Blimp1) expression in bone marrow mononuclear cells on the prognosis of patients with multiple myeloma...
  48. Ming Z, Gong A, Wang Y, Zhang X, Li M, Li Y, et al. Trans-suppression of host CDH3 and LOXL4 genes during Cryptosporidium parvum infection involves nuclear delivery of parasite Cdg7_FLc_1000 RNA. Int J Parasitol. 2018;48:423-431 pubmed publisher
    ..parvum infection. Host delivery of Cdg7_FLc_1000 promoted the PH domain zinc finger protein 1 (PRDM1)-mediated H3K9 methylation associated with trans-suppression in the CDH3 gene locus, but not the LOXL4 gene...
  49. Seddiki N, Phetsouphanh C, Swaminathan S, Xu Y, Rao S, Li J, et al. The microRNA-9/B-lymphocyte-induced maturation protein-1/IL-2 axis is differentially regulated in progressive HIV infection. Eur J Immunol. 2013;43:510-20 pubmed publisher
    ..In this study, we demonstrate that B-lymphocyte-induced maturation protein-1 (Blimp-1/Prdm1) is highly expressed in CD4(+) T cells from chronically HIV-infected (CHI) patients compared to cells from long-..
  50. Xing J, Zhang C, Yang X, Wang S, Wang Z, Li X, et al. CXCR5+CD8+ T cells infiltrate the colorectal tumors and nearby lymph nodes, and are associated with enhanced IgG response in B cells. Exp Cell Res. 2017;356:57-63 pubmed publisher
    ..T cells, the CXCR5+CD8+ T cells demonstrated significantly higher Bcl-6 expression and lower Blimp1 expression, suggesting that CXCR5+CD8+ T cells might represent a memory CD8+ T ..
  51. Zhang Y, Xie H, Chen Y, Jiao B, Shen Z, Chen S, et al. Loss of promoter methylation contributes to the expression of functionally impaired PRDM1? isoform in diffuse large B-cell lymphoma. Int J Hematol. 2010;92:439-44 pubmed publisher
    The positive regulatory domain I (PRDM1) is a transcriptional repressor that plays an important role in the B-cell differentiation...
  52. Brach D, Johnston Blackwell D, Drew A, Lingaraj T, Motwani V, Warholic N, et al. EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL. Mol Cancer Ther. 2017;16:2586-2597 pubmed publisher
    ..that cell lines treated with tazemetostat show an increase in the B-cell maturation regulator, PRDM1/BLIMP1, and gene signatures corresponding to more advanced stages of maturation...
  53. Nelson A, Mould A, Bikoff E, Robertson E. Mapping the chromatin landscape and Blimp1 transcriptional targets that regulate trophoblast differentiation. Sci Rep. 2017;7:6793 pubmed publisher
    ..Additionally, transcriptional targets recognized by the zinc finger transcriptional repressor Prdm1/Blimp1, an essential regulator of placenta development, were identified in ChIP-seq experiments...
  54. Schmidlin H, DIEHL S, Nagasawa M, Scheeren F, Schotte R, Uittenbogaart C, et al. Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression. Blood. 2008;112:1804-12 pubmed publisher
    ..By chromatin immunoprecipitation and assays using an inducible Spi-B construct BLIMP1 and XBP-1 were identified as direct target genes of Spi-B mediated repression...
  55. Wu L, Guo Q, Yang J, Ni B. Tumor Necrosis Factor Alpha Promotes Osteoclast Formation Via PI3K/Akt Pathway-Mediated Blimp1 Expression Upregulation. J Cell Biochem. 2017;118:1308-1315 pubmed publisher
    ..B lymphocyte-induced maturation protein-1 (Blimp1) is a transcriptional repressor that plays crucial roles in the differentiation and/or function of various kinds ..
  56. Wilkinson S, Vanpatten K, Fernandez D, Brunhoeber P, Garsha K, Glinsmann Gibson B, et al. Partial plasma cell differentiation as a mechanism of lost major histocompatibility complex class II expression in diffuse large B-cell lymphoma. Blood. 2012;119:1459-67 pubmed publisher
    ..overlap with PBL and demonstrate an inverse correlation between MHC II and plasma cell markers MUM1, PRDM1/Blimp1, and XBP1s...
  57. Jiang H, Hou J. [Effect of low-dose 2-methoxyestradiol on the expressions of two isoforms of PRDM1 gene in myeloma]. Zhonghua Xue Ye Xue Za Zhi. 2009;30:38-41 pubmed
    To investigate the effects of low-dose 2-methoxyestradiol (2ME2) on the expression of two isoforms of PRDM1 gene (PRDM1alpha with and PRDM1beta without PR-domain) during the myeloma cell differentiation...
  58. Wang W, Yan L, Liu Z, Liu L, Lin J, Liu Z, et al. HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells. Nat Commun. 2017;8:363 pubmed publisher
    ..Here the authors show that lymphoma-associated Blimp-1 mutants are selectively recognized by HSP70-Hrd1, which leads to their accelerated degradation and propose HSP70 inhibition as a therapeutic approach for certain lymphomas. ..
  59. Bankoti R, Ogawa C, Nguyen T, Emadi L, Couse M, Salehi S, et al. Differential regulation of Effector and Regulatory T cell function by Blimp1. Sci Rep. 2017;7:12078 pubmed publisher
    The transcriptional regulator Blimp1 plays crucial roles in controlling terminal differentiation in several lineages...
  60. Tsai T, JOHNSON J, White Y, John J. The molecular characterization of porcine egg precursor cells. Oncotarget. 2017;8:63484-63505 pubmed publisher
    ..Expression of the pluripotent markers Sox2 and Oct4, and the primitive germ cell markers Blimp1 and Stella were not detected...
  61. Sasaki K, Nakamura T, Okamoto I, Yabuta Y, Iwatani C, Tsuchiya H, et al. The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion. Dev Cell. 2016;39:169-185 pubmed publisher
    ..Here, we show that in cynomolgus monkeys, the SOX17/TFAP2C/BLIMP1-positive primordial germ cells (cyPGCs) originate from the dorsal amnion at embryonic day 11 (E11) prior to ..
  62. Liu Y, Wang R, Cheng X. [Down-regulated expression of Blimp-1 mRNA in monocytes from patients with active tuberculosis]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015;31:949-52 pubmed
  63. Mackay L, Minnich M, Kragten N, Liao Y, Nota B, Seillet C, et al. Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes. Science. 2016;352:459-63 pubmed publisher
    ..we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice...
  64. Lotz C, Mutallib S, Oehlrich N, Liewer U, Ferreira E, Moos M, et al. Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL. J Immunol. 2005;175:1301-9 pubmed
    ..We conclude that transcription factors governing terminal cellular differentiation may provide MM- and tumor-associated CTL epitopes. ..
  65. Buettner M, Lang A, Tudor C, Meyer B, Cruchley A, Barros M, et al. Lytic Epstein-Barr virus infection in epithelial cells but not in B-lymphocytes is dependent on Blimp1. J Gen Virol. 2012;93:1059-64 pubmed publisher
    ..Differentiation of squamous epithelial cells depends on B-lymphocyte-induced maturation protein 1 (Blimp1)...
  66. Ellinghaus D, Zhang H, Zeissig S, Lipinski S, Till A, Jiang T, et al. Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies. Gastroenterology. 2013;145:339-47 pubmed publisher
    ..We identified rare missense mutations in PR domain-containing 1 (PRDM1) and associated these with CD...
  67. Boi M, Rinaldi A, Kwee I, Bonetti P, Todaro M, Tabbò F, et al. PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma. Blood. 2013;122:2683-93 pubmed publisher
    ..The latter gene, coding for BLIMP1, was inactivated by multiple mechanisms, more frequently, but not exclusively, in ALK(-)ALCL...
  68. Ma J, Nie K, Redmond D, Liu Y, Elemento O, Knowles D, et al. EBV-miR-BHRF1-2 targets PRDM1/Blimp1: potential role in EBV lymphomagenesis. Leukemia. 2016;30:594-604 pubmed publisher
    PRDM1/Blimp1, a master regulator of B-cell terminal differentiation, has been identified as a tumor suppressor gene in aggressive lymphomas, including diffuse large B-cell lymphoma (DLBCL)...
  69. Yang G, Yang X, Zhang J, Li G, Zheng D, Peng A, et al. Transcriptional repressor Blimp1 regulates follicular regulatory T-cell homeostasis and function. Immunology. 2018;153:105-117 pubmed publisher
    The B-lymphocyte-induced maturation protein 1 (Blimp1) regulates T-cell homeostasis and function. Loss of Blimp1 could double the proportion of follicular regulatory T (Tfr) cells...
  70. Adib S, Valojerdi M. Molecular assessment, characterization, and differentiation of theca stem cells imply the presence of mesenchymal and pluripotent stem cells in sheep ovarian theca layer. Res Vet Sci. 2017;114:378-387 pubmed publisher
    ..OLCs expressed oocyte-specific marker genes including, ZP3, ZP2, GDF9, SYCP3, PRDM1, STELLA, FRAGILIS, DAZL, as well as POU5F1, and showed separated sphere structure...
  71. Chiou S, Risca V, Wang G, Yang D, Grüner B, Kathiria A, et al. BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer. Cancer Discov. 2017;7:1184-1199 pubmed publisher
    ..Global gene expression profiling and functional analyses uncovered the transcription factor BLIMP1 as a driver of PDAC metastasis...
  72. Shimshon L, Michaeli A, Hadar R, Nutt S, David Y, Navon A, et al. SUMOylation of Blimp-1 promotes its proteasomal degradation. FEBS Lett. 2011;585:2405-9 pubmed publisher
    ..Increase in SENP1 activity stabilized Blimp-1, while a decrease promoted its degradation. Our data indicate that SUMOylation of Blimp-1 regulates its intracellular stability. ..
  73. Lin I, Chiu F, Yeang C, Chen H, Chuang C, Yang S, et al. Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells. Stem Cell Reports. 2014;2:189-204 pubmed publisher
    ..The transcriptional repressor Prdm1/Blimp-1 is known to play a critical role in controlling germ cell specification in mice...
  74. Nagel S, Pommerenke C, Meyer C, Kaufmann M, MacLeod R, Drexler H. NKL homeobox gene MSX1 acts like a tumor suppressor in NK-cell leukemia. Oncotarget. 2017;8:66815-66832 pubmed publisher
    ..profiling and chromosomal analyses of NK-cell lines demonstrated amplification of IRF4 at 6p25 and deletion of PRDM1 at 6q21, highlighting their potential oncogenic impact...
  75. Stobdan T, Akbari A, Azad P, Zhou D, Poulsen O, Appenzeller O, et al. New insights into the genetic basis of Monge's disease and adaptation to high-altitude. Mol Biol Evol. 2017;: pubmed publisher
    ..g., SENP1) and also unreported ones SGK3, COPS5, PRDM1 and IFT122 in CMS...
  76. Severa M, Coccia E, Fitzgerald K. Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. J Biol Chem. 2006;281:26188-95 pubmed
    ..Moreover, positive regulatory domain I-binding factor 1 (PRDI-BF1, also called BLIMP1) binds the ISRE sites and competes with ISGF3 binding in a virus inducible manner to inhibit Viperin transcription...
  77. Sellheyer K, Krahl D. Blimp-1: a marker of terminal differentiation but not of sebocytic progenitor cells. J Cutan Pathol. 2010;37:362-70 pubmed publisher
  78. Weiss J, Chen W, Nyuydzefe M, Trzeciak A, Flynn R, Tonra J, et al. ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings. Sci Signal. 2016;9:ra73 pubmed publisher
    ..activity decreased the abundance of the transcriptional regulator Bcl6 (B cell lymphoma 6) and increased that of Blimp1 by reducing the binding of signal transducer and activator of transcription 3 (STAT3) and increasing that of STAT5 ..
  79. Gateva V, Sandling J, Hom G, Taylor K, Chung S, Sun X, et al. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet. 2009;41:1228-33 pubmed publisher
    ..27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19)...
  80. Kasowitz S, Luo M, Ma J, Leu N, Wang P. Embryonic lethality and defective male germ cell development in mice lacking UTF1. Sci Rep. 2017;7:17259 pubmed publisher
    ..Male mice with a germline-specific deletion of Utf1 resulting from Prdm1-Cre mediated recombination are born with significantly fewer gonocytes and exhibit defective spermatogenesis and ..
  81. Luo J, Niu X, Liu H, Zhang M, Chen M, Deng S. Up-regulation of transcription factor Blimp1 in systemic lupus erythematosus. Mol Immunol. 2013;56:574-82 pubmed publisher
    b>B lymphocyte induced maturation protein 1 (Blimp1) is a transcription factor that is critical for differentiation and antibody production in plasma cells...
  82. Baytak E, Gong Q, Akman B, Yuan H, Chan W, Kucuk C. Whole transcriptome analysis reveals dysregulated oncogenic lncRNAs in natural killer/T-cell lymphoma and establishes MIR155HG as a target of PRDM1. Tumour Biol. 2017;39:1010428317701648 pubmed publisher
    ..Despite previous reports that showed potential tumor suppressors, such as PRDM1 or oncogenes associated with the etiology of this malignancy, the role of long non-coding RNAs in natural killer/T-..