Gene Symbol: PPP5C
Description: protein phosphatase 5 catalytic subunit
Alias: PP5, PPP5, PPT, serine/threonine-protein phosphatase 5, PP-T, protein phosphatase T
Species: human
Products:     PPP5C

Top Publications

  1. Ikeda K, Ogawa S, Tsukui T, Horie Inoue K, Ouchi Y, Kato S, et al. Protein phosphatase 5 is a negative regulator of estrogen receptor-mediated transcription. Mol Endocrinol. 2004;18:1131-43 pubmed
    ..A yeast two-hybrid screening identified a serine/threonine protein phosphatase (PP5) as an interactant of ERbeta (1-481), a dominant negative ERbeta mutant...
  2. Mo S, Hou X, Hao X, Cai J, Liu X, Chen W, et al. EYA4 inhibits hepatocellular carcinoma growth and invasion by suppressing NF-κB-dependent RAP1 transactivation. Cancer Commun (Lond). 2018;38:9 pubmed publisher
  3. Campbell L, Raheem I, Malemud C, Askari A. The Relationship between NALP3 and Autoinflammatory Syndromes. Int J Mol Sci. 2016;17: pubmed publisher
    ..In general, these autoinflammatory disorders have shown a clinical response to interleukin-1 (IL-1) antagonists, suggesting that the NALP3 inflammasome serves a critical role in their pathogenesis. ..
  4. Huang C, Hsieh F, Wang C, Chen L, Chang S, Tsai M, et al. Palbociclib enhances radiosensitivity of hepatocellular carcinoma and cholangiocarcinoma via inhibiting ataxia telangiectasia-mutated kinase-mediated DNA damage response. Eur J Cancer. 2018;102:10-22 pubmed publisher
    ..that the inhibitory effect of palbociclib on RT-induced ATM kinase activation is mediated by protein phosphatase 5 (PP5)...
  5. PENBERTHY K, BUCKLEY M, Arandjelovic S, Ravichandran K. Ex vivo modulation of the Foxo1 phosphorylation state does not lead to dysfunction of T regulatory cells. PLoS ONE. 2017;12:e0173386 pubmed publisher
    ..Our data also highlight the caveat in using ex vivo assays of Treg cell differentiation and function, in that while these assays are useful, they may not fully recapitulate Treg cell phenotypes that are observed in vivo. ..
  6. Ritorto M, Rhode H, Vogel A, Borlak J. Regulation of glycosylphosphatidylinositol-anchored proteins and GPI-phospholipase D in a c-Myc transgenic mouse model of hepatocellular carcinoma and human HCC. Biol Chem. 2016;397:1147-1162 pubmed publisher
    ..The findings broaden the perspective of molecular targeted therapies and disease monitoring. ..
  7. Desbonnet C, Tait Kamradt A, García Solache M, Dunman P, Coleman J, Arthur M, et al. Involvement of the Eukaryote-Like Kinase-Phosphatase System and a Protein That Interacts with Penicillin-Binding Protein 5 in Emergence of Cephalosporin Resistance in Cephalosporin-Sensitive Class A Penicillin-Binding Protein Mutants in Enterococcus . MBio. 2016;7:e02188-15 pubmed publisher
    ..P5AP may represent a promising new target, inhibition of which could restore cephalosporin susceptibility to E. faecium. ..
  8. Matsuura K, Otani M, Takano M, Kadoyama K, Matsuyama S. The influence of chronic ibuprofen treatment on proteins expressed in the mouse hippocampus. Eur J Pharmacol. 2015;752:61-8 pubmed publisher
    ..We propose that these identified proteins and phosphoproteins play an important role in decreasing the incidence of AD, especially impaired learning and memory functions. ..
  9. Alcalay N, Brantley J, Sharma M, Gooch J, Vanden Heuvel G. Ectopic expression of the homeobox gene Cux-1 rescues calcineurin inhibition in mouse embryonic kidney cultures. Dev Dyn. 2007;236:184-91 pubmed
    ..Taken together, our results demonstrate that ectopic expression of Cux-1 can rescue the effects of CsA inhibition of CnA and suggest that Cux-1 may be regulated by calcineurin A...

More Information

Publications126 found, 100 shown here

  1. Sitprija V, Sitprija S. Marine toxins and nephrotoxicity:Mechanism of injury. Toxicon. 2019;161:44-49 pubmed publisher
    ..In this respect repeated consumption of plankton toxin contaminated seafood is a risk of developing chronic renal disease. The subject deserves more clinical study and scientific attention. ..
  2. Chen W, Chang C, Li J, Wang J, Wu C, Kuan Y, et al. Anti-inflammatory and Neuroprotective Effects of Fungal Immunomodulatory Protein Involving Microglial Inhibition. Int J Mol Sci. 2018;19: pubmed publisher
    ..These findings suggest that GMI may have considerable potential towards the treatment of neuroinflammation-mediated neurodegenerative diseases. ..
  3. Cinar R, Godlewski G, Liu J, Tam J, Jourdan T, Mukhopadhyay B, et al. Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides. Hepatology. 2014;59:143-53 pubmed publisher
    ..ECs induce CB1 R-mediated, endoplasmic reticulum stress-dependent synthesis of specific ceramide subspecies in the liver, which plays a key role in obesity-related hepatic insulin resistance. ..
  4. Calarco L, Ellis J. Annotating the 'hypothetical' in hypothetical proteins: In-silico analysis of uncharacterised proteins for the Apicomplexan parasite, Neospora caninum. Vet Parasitol. 2019;265:29-37 pubmed publisher
    ..caninum, that may be involved in host-cell interaction, parasite adhesion, and invasion, thereby implicating them as potential targets to exploit in the development of control options against the disease. ..
  5. Marchand B, Arsenault D, Raymond Fleury A, Boisvert F, Boucher M. Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells. J Biol Chem. 2015;290:5592-605 pubmed publisher
    ..Altogether, our data uncover new functions under the control of GSK3 in pancreatic cancer cells in addition to providing key insight into TFEB regulation. ..
  6. Liao H, Chyuan I, Wu C, Lin S, Chen K, Tsai H, et al. Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice. Rheumatology (Oxford). 2015;54:1317-26 pubmed publisher
    ..Our study suggests that PSTPIP2 could play a role in innate immunity and development of autoinflammatory bone disorders, and may be associated with the pathogenesis of human SAPHO syndrome. ..
  7. Navarro Marquez M, Torrealba N, Troncoso R, Vasquez Trincado C, Rodriguez M, Morales P, et al. Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1653-1662 pubmed publisher
    ..Based on these findings, we conclude that Herpud1 is necessary for adequate insulin-induced glucose uptake due to its role in Ca2+/calcineurin regulation in L6 myotubes. ..
  8. Raedler D, Ballenberger N, Klucker E, Böck A, Otto R, Prazeres da Costa O, et al. Identification of novel immune phenotypes for allergic and nonallergic childhood asthma. J Allergy Clin Immunol. 2015;135:81-91 pubmed publisher
    ..Identification of these unique pathways provides a profound basis for future strategies for individualized prediction of asthma development, disease course, and prevention. ..
  9. He C, Qiu Y, Han P, Chen Y, Zhang L, Yuan Q, et al. ER stress regulating protein phosphatase 2A-B56?, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes. Cell Death Dis. 2018;9:762 pubmed publisher
  10. Mandal C, Das F, Ganapathy S, Harris S, Choudhury G, Ghosh Choudhury N. Bone Morphogenetic Protein-2 (BMP-2) Activates NFATc1 Transcription Factor via an Autoregulatory Loop Involving Smad/Akt/Ca2+ Signaling. J Biol Chem. 2016;291:1148-61 pubmed publisher
  11. Nagappan A, Jung D, Kim J, Jung M. Protective Effects of Gomisin N against Hepatic Cannabinoid Type 1 Receptor-Induced Insulin Resistance and Gluconeogenesis. Int J Mol Sci. 2018;19: pubmed publisher
    ..These findings demonstrate that GN protects against hepatic CB1-mediated impairment of insulin signaling and gluconeogenesis, thereby contributing to the amelioration of hyperglycemia. ..
  12. Chen E, Choy M, Petrényi K, Konya Z, Erdodi F, Dombradi V, et al. Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans. MBio. 2016;7: pubmed publisher
    ..Most importantly, however, these unique features identified PPZ1 as a potential target for the development of novel antifungal therapeutics that will provide new, safe, and potent treatments for candidiasis in humans. ..
  13. Baumgartner U, Berger F, Hashemi Gheinani A, Burgener S, Monastyrskaya K, Vassella E. miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer. Mol Cancer. 2018;17:44 pubmed publisher
    ..Our results provide insight into the importance of targeting PPP2R5E and BCL2L11 by miR-19b in oncogenic processes of NSCLC. Attenuation of miR-19b expression could potentially be exploited in adjuvant therapy of EGFR mutant NSCLC. ..
  14. Jain P, Lavorgna A, Sehgal M, Gao L, Ginwala R, Sagar D, et al. Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB. Retrovirology. 2015;12:23 pubmed publisher
    ..We demonstrate the involvement of MEF-2 in Tax-mediated LTR activation, viral replication, and T-cell transformation in correlation with its heightened expression in ATL patients through direct binding to DNA within the HTLV-1 LTR. ..
  15. Arumugam B, Vairamani M, Partridge N, Selvamurugan N. Characterization of Runx2 phosphorylation sites required for TGF-?1-mediated stimulation of matrix metalloproteinase-13 expression in osteoblastic cells. J Cell Physiol. 2018;233:1082-1094 pubmed publisher
    ..Hence, this study contributes to the knowledge of events governing bone remodeling and bone-related diseases. ..
  16. Shah S, Hussain T, Zhao D, Yang L. A central role for calcineurin in protein misfolding neurodegenerative diseases. Cell Mol Life Sci. 2017;74:1061-1074 pubmed publisher
  17. Millson S, Piper P. Insights from yeast into whether the inhibition of heat shock transcription factor (Hsf1) by rapamycin can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor. Oncotarget. 2014;5:5054-64 pubmed
    ..as well as with the loss of Ppt1, the Hsp90-interacting protein phosphatase that is the ortholog of mammalian PP5. Unexpectedly Hsf1 activation was found to have a requirement for the rapamycin binding immunophilin FKBP12 even in ..
  18. Maddhuri S, Bandaru S, Bhukya C, Cingeetham V, Malempati A, Deepika M, et al. Association of CnB 5I/5D promoter gene polymorphism and serum calcineurin levels in early onset of coronary artery disease of south Indian cohort. Gene. 2017;632:1-6 pubmed publisher
    ..19 (95% CI 1.40-7.24) and p=0.001]. The results suggest that 5-base pair deletion results in increased serum calcineurin levels and may trigger up regulation of calcineurin which mediates vascular inflammation and atherosclerosis in CAD. ..
  19. Yoshikawa Y, Hirata N, Terada H, Sawashita Y, Yamakage M. Identification of Candidate Genes and Pathways in Dexmedetomidine-Induced Cardioprotection in the Rat Heart by Bioinformatics Analysis. Int J Mol Sci. 2019;20: pubmed publisher
    ..The results indicated some possible key genes and pathways that seem to be of significance in DEX-induced cardioprotection, although miRNAs seem to be unlikely to contribute to cardioprotection induced by DEX. ..
  20. Kim K, Myers R, Lee J, Igartua C, Lee K, Kim Y, et al. Genome-wide association study of recalcitrant atopic dermatitis in Korean children. J Allergy Clin Immunol. 2015;136:678-684.e4 pubmed publisher
  21. Phillips F, Gurung P, Kanneganti T. Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease. Gut Microbes. 2016;7:334-341 pubmed
  22. Neitzel L, Broadus M, Zhang N, Sawyer L, Wallace H, Merkle J, et al. Characterization of a cdc14 null allele in Drosophila melanogaster. Biol Open. 2018;7: pubmed publisher
    ..In addition, we show that cdc14 null mutants have defects in lipid metabolism and resistance to starvation. These studies highlight the diversity of Cdc14 function in eukaryotes despite its structural conservation. ..
  23. Li J, Wang R, Tang D. Vimentin dephosphorylation at ser-56 is regulated by type 1 protein phosphatase in smooth muscle. Respir Res. 2016;17:91 pubmed publisher
    ..PP1 regulates actin polymerization by modulating the dissociation of p130CAS from vimentin, but not by affecting c-Abl tyrosine kinase. ..
  24. Sager R, Woodford M, Backe S, Makedon A, Baker Williams A, DiGregorio B, et al. Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90. Cell Rep. 2019;26:1344-1356.e5 pubmed publisher
    ..We further demonstrate that serine/threonine protein phosphatase 5 (PP5) dephosphorylates FNIP1, allowing the addition of O-GlcNAc (O-linked N-acetylglucosamine) to the priming serine-938...
  25. Wei M, Zheng Z, Shi L, Jin Y, Ji L. Natural polyphenol chlorogenic acid protects against acetaminophen-induced hepatotoxicity by activating ERK/Nrf2 antioxidative pathway. Toxicol Sci. 2017;: pubmed publisher
    ..CGA decreased the expression of protein phosphatases including PP2A subunit A (PP2A-A) and PP5, and induced the sustained ERK1/2 phosphorylation...
  26. Li Y, Dijkers P. Specific calcineurin isoforms are involved in Drosophila toll immune signaling. J Immunol. 2015;194:168-76 pubmed publisher
    ..Altogether, these data identify a novel input, calcineurin, in Toll immune signaling and demonstrate involvement of specific calcineurin isoforms in Drosophila NF-κB signaling. ..
  27. Trinkle Mulcahy L, Andersen J, Lam Y, Moorhead G, Mann M, Lamond A. Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. J Cell Biol. 2006;172:679-92 pubmed
    ..The data indicate that Repo-Man forms an essential complex with PP1gamma and is required for the recruitment of PP1 to chromatin. ..
  28. Martinez Rios C, Jariwala M, Highmore K, Duffy K, Spiegel L, Laxer R, et al. Imaging findings of sterile pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome: differential diagnosis and review of the literature. Pediatr Radiol. 2019;49:23-36 pubmed publisher
    ..Although uncommon, the potential clinical implications of PAPA syndrome warrant an appropriate diagnosis in a timely fashion. ..
  29. Shang L, Henderson L, Cho M, Petrey D, Fong C, Haude K, et al. De novo missense variants in PPP2R5D are associated with intellectual disability, macrocephaly, hypotonia, and autism. Neurogenetics. 2016;17:43-9 pubmed publisher
    ..Our data provides further support for PPP2R5D as a genetic cause of ID. ..
  30. Bouhaddada R, Nélieu S, Nasri H, Delarue G, Bouaïcha N. High diversity of microcystins in a Microcystis bloom from an Algerian lake. Environ Pollut. 2016;216:836-844 pubmed publisher
    ..MC-RR was the major (43.4%) in the bloom sample. ..
  31. Göder A, Emmerich C, Nikolova T, Kiweler N, Schreiber M, Kühl T, et al. HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130. Nat Commun. 2018;9:764 pubmed publisher
    ..Thus, PR130 controls cell fate decisions upon replicative stress. ..
  32. Lemos P, Ruiz Roldán C, Hera C. Role of the phosphatase Ptc1 in stress responses mediated by CWI and HOG pathways in Fusarium oxysporum. Fungal Genet Biol. 2018;118:10-20 pubmed publisher
    ..Moreover, Δptc1 contained fragmented vacuoles even in absence of the osmotic stressor, supporting the involvement of Ptc1 in the HOG pathway. ..
  33. Hsieh F, Chen Y, Hung M, Chu P, Tsai M, Chen L, et al. Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6-independent manner. Mol Oncol. 2017;11:1035-1049 pubmed publisher
    ..cells through a mechanism involving 5' AMP-activated protein kinase (AMPK) activation and protein phosphatase 5 (PP5) inhibition...
  34. Lucas S, Armstrong D. Protein phosphatase modulation of somatostatin receptor signaling in the mouse hippocampus. Neuropharmacology. 2015;99:232-41 pubmed publisher
    ..Knockdown of protein phosphatase 5, by Cre recombinase mediated deletion of the floxed Ppp5c gene, blocks the hyperpolarisation independent effect of SST, and reduces the hyperpolarisation dependent effect ..
  35. Xie J, Han M, Zhang M, Deng H, Wu W. PP5 (PPP5C) is a phosphatase of Dvl2. Sci Rep. 2018;8:2715 pubmed publisher
    ..Here, we identified PP5 (PPP5C) as a phosphatase of Dvl2. PP5 interacts with and can directly dephosphorylate Dvl2...
  36. Yong W, Ueki K, Chou D, Reeves S, von Deimling A, Gusella J, et al. Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3. Genomics. 1995;29:533-6 pubmed
    ..library revealed a protein serine-threonine phosphatase with a tetratricopeptide motif, almost identical to human PPP5C (PP5) and highly homologous to rat PPT. Northern blotting demonstrated expression in most tissues, including brain...
  37. Schülke J, Wochnik G, Lang Rollin I, Gassen N, Knapp R, Berning B, et al. Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors. PLoS ONE. 2010;5:e11717 pubmed publisher
    ..The differential effects of the TPR proteins on steroid receptors bear on all physiological processes related to steroid hormone activity. ..
  38. Karkanas P, Brown K, Fisher E, Jacobs Z, Marean C. Interpreting human behavior from depositional rates and combustion features through the study of sedimentary microfacies at site Pinnacle Point 5-6, South Africa. J Hum Evol. 2015;85:1-21 pubmed publisher
    Using fine and coarse resolution geoarchaeological studies at the Middle Stone Age site of PP5-6 at Pinnacle Point, Mossel Bay, South Africa, we discovered different patterns of anthropogenic input and changes in behavior through time...
  39. Haslbeck V, Drazic A, Eckl J, Alte F, Helmuth M, Popowicz G, et al. Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism. Biosci Rep. 2015;35: pubmed publisher
    Protein phosphatase 5 (PP5) is an evolutionary conserved serine/threonine phosphatase...
  40. Regidor Cerrillo J, García Lunar P, Pastor Fernández I, Álvarez García G, Collantes Fernández E, Gómez Bautista M, et al. Neospora caninum tachyzoite immunome study reveals differences among three biologically different isolates. Vet Parasitol. 2015;212:92-9 pubmed publisher
    ..These results suggest that variations in the immunome profiles rely on the immune response induced by each isolate and that these differentially recognized antigens could be investigated as putative virulence markers of neosporosis. ..
  41. Sugiyama Y, Yamashita S, Uezato Y, Senga Y, Katayama S, Goshima N, et al. Phosphorylated TandeMBP: A unique protein substrate for protein phosphatase assay. Anal Biochem. 2016;513:47-53 pubmed publisher
    ..for PPM family phosphatases (PPM1A, PPM1B, PPM1D, PPM1F, PPM1G, PPM1H, PPM1K, and PPM1M) and PPP family phosphatase PP5. Various phosphatase activities were also detected with high sensitivity in gel filtration fractions from mouse ..
  42. Hu M, Meng T, Jiang Z, Dong M, Schatten H, Xu X, et al. Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity. PLoS Genet. 2016;12:e1006513 pubmed publisher
    ..Our findings uncover an important role for PP6 as an indispensable guardian of genomic integrity of the lengthy prophase I oocyte arrest, maintenance of primordial follicle pool, and thus female fertility. ..
  43. Goedert M, Cohen E, Jakes R, Cohen P. p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]. FEBS Lett. 1992;312:95-9 pubmed
    ..Of the major serine/threonine protein phosphatases found in mammalian tissues only protein phosphatase 2A (PP2A) could dephosphorylate tau phosphorylated in this manner, with PP2A1 being the most effective form of the enzyme. ..
  44. Hahn J. Regulation of Nod1 by Hsp90 chaperone complex. FEBS Lett. 2005;579:4513-9 pubmed
    ..Chp-1 interacts with the tetratricopeptide repeat (TPR) domain of protein phosphatase 5 (PP5) and the ATPase domain of Hsp90 via two distinct zinc-binding cysteine and histidine rich domains (CHORDs)...
  45. Sürmeli Z, Gursoy P, Erdogan A, Bozkurt E, Atmaca H, Uzunoglu S, et al. Combination of zoledronic acid and serine/threonine phosphatase inhibitors induces synergistic cytotoxicity and apoptosis in human breast cancer cells via inhibition of PI3K/Akt pathway. Tumour Biol. 2016;37:3665-73 pubmed publisher
    ..In conclusion, synergistic apoptotic effect of the combination treatment is correlated with the block of the PI3K/Akt signal pathway in breast cancer cells. ..
  46. Serifi I, Tzima E, Soupsana K, Karetsou Z, Beis D, Papamarcaki T. The zebrafish homologs of SET/I2PP2A oncoprotein: expression patterns and insights into their physiological roles during development. Biochem J. 2016;473:4609-4627 pubmed
    ..Collectively, our results suggest that seta and setb are required during embryogenesis and play roles in the zebrafish sensory system development. ..
  47. Jeong H, Woo C, Lee B, Khang S, Nam S, Choi J. Protein Phosphatase Magnesium-Dependent 1? (PPM1D) Expression as a Prognostic Marker in Adult Supratentorial Diffuse Astrocytic and Oligodenroglial Tumors. J Pathol Transl Med. 2017;: pubmed publisher
    ..In this study, we evaluate the utility of PPM1D as a prognostic biomarker of adult supratentorial diffuse astrocytic and oligodenroglial tumors...
  48. Huang S, Shu L, Easton J, Harwood F, Germain G, Ichijo H, et al. Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity. J Biol Chem. 2004;279:36490-6 pubmed
    ..In Rh30 cells, ASK1 was found to physically interact with protein phosphatase 5 (PP5), previously identified as a negative regulator of ASK1...
  49. Kauko O, Westermarck J. Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer. Int J Biochem Cell Biol. 2018;96:157-164 pubmed publisher
  50. Gangula N, Maddika S. WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). J Biol Chem. 2013;288:34545-54 pubmed publisher
    ..Together, our results reveal WDR48 and USP12 as novel PHLPP1 regulators and potential suppressors of tumor cell survival. ..
  51. Oberoi J, Dunn D, Woodford M, Mariotti L, Schulman J, Bourboulia D, et al. Structural and functional basis of protein phosphatase 5 substrate specificity. Proc Natl Acad Sci U S A. 2016;113:9009-14 pubmed publisher
    The serine/threonine phosphatase protein phosphatase 5 (PP5) regulates hormone- and stress-induced cellular signaling by association with the molecular chaperone heat shock protein 90 (Hsp90)...
  52. Hu B, Wang X, Hu S, Ying X, Wang P, Zhang X, et al. miR-21-mediated Radioresistance Occurs via Promoting Repair of DNA Double Strand Breaks. J Biol Chem. 2017;292:3531-3540 pubmed publisher
    ..The miR-21-promoted NHEJ occurs through targeting GSK3B (a novel target of miR-21), which affects the CRY2/PP5 pathway and in turn increases DNA-PKcs activity...
  53. Chen Y, Hung M, Chu P, Chao T, Tsai M, Chen L, et al. Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase. Biochem Pharmacol. 2017;138:49-60 pubmed publisher
    ..Ser/Thr protein phosphatase 5 (PP5) is known to participate in glucocorticoid receptor (GR) and stress-induced signaling cascades that regulate cell ..
  54. Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, et al. Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress. EMBO J. 2001;20:6028-36 pubmed
    ..A yeast two-hybrid screening identified a serine/threonine protein phosphatase 5 (PP5) as a binding partner of ASK1...
  55. Apostolidis S, Rodríguez Rodríguez N, Suárez Fueyo A, Dioufa N, Ozcan E, Crispín J, et al. Phosphatase PP2A is requisite for the function of regulatory T cells. Nat Immunol. 2016;17:556-64 pubmed publisher
    ..In the absence of PP2A, T(reg) cells altered their metabolic and cytokine profile and were unable to suppress effector immune responses. Therefore, PP2A is required for the function of T(reg) cells and the prevention of autoimmunity. ..
  56. Twiner M, Doucette G, Pang Y, Fang C, Forsyth C, Miles C. Structure-Activity Relationship Studies Using Natural and Synthetic Okadaic Acid/Dinophysistoxin Toxins. Mar Drugs. 2016;14: pubmed
    ..Preliminary screening of 21 human and yeast phosphatases indicated that only three ser/thr PPs (PP2a, PP1, PP5) were inhibited by physiologically saturating concentrations of DTX2 (200 nM)...
  57. Liao F, Hsiao W, Lin Y, Chan Y, Huang C. T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4. Cell Cycle. 2016;15:1073-83 pubmed publisher
    ..In summary, our results indicate that PP4 is an essential modulator for T cell proliferation and immune responses; they further suggest a potential link between PP4 functions, AMPK activation and G1-S arrest in activated T cells. ..
  58. Yamaguchi F, Tsuchiya M, Shimamoto S, Fujimoto T, Tokumitsu H, Tokuda M, et al. Oxidative Stress Impairs the Stimulatory Effect of S100 Proteins on Protein Phosphatase 5 Activity. Tohoku J Exp Med. 2016;240:67-78 pubmed publisher
    ..Protein phosphatase 5 (PP5) is a serine/threonine phosphatase involved in oxidative stress responses...
  59. Thompson J, Williams C. Protein Phosphatase 2A in the Regulation of Wnt Signaling, Stem Cells, and Cancer. Genes (Basel). 2018;9: pubmed publisher
  60. Das A, Cohen P, Barford D. The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. EMBO J. 1998;17:1192-9 pubmed
    ..Here, we report the crystal structure of the TPR domain of a protein phosphatase, PP5. Each of the three TPR motifs of this domain consist of a pair of antiparallel alpha-helices of equivalent length...
  61. Zeke T, Morrice N, Vázquez Martin C, Cohen P. Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole. Biochem J. 2005;385:45-56 pubmed
    b>Ppp5 (protein phosphatase 5) is a serine/threonine protein phosphatase that has been conserved throughout eukaryotic evolution...
  62. Sekine Y, Hatanaka R, Watanabe T, Sono N, Iemura S, Natsume T, et al. The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. Mol Cell. 2012;48:692-704 pubmed publisher
    ..that Kelch domain containing 10 (KLHDC10), a mammalian ortholog of Slim, interacted with Protein phosphatase 5 (PP5), which has been shown to inactivate ASK1 in response to ROS...
  63. Woodford M, Dunn D, Blanden A, Capriotti D, Loiselle D, Prodromou C, et al. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Nat Commun. 2016;7:12037 pubmed publisher
    ..Our findings suggest that FNIPs expression can potentially serve as a predictive indicator of tumour response to Hsp90 inhibitors. ..
  64. Zhou G, Golden T, Aragon I, Honkanen R. Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade. J Biol Chem. 2004;279:46595-605 pubmed
    ..Hypoxia-induced ASK-1/MKK-4/JNK signaling is suppressed by serine/threonine protein phosphatase type 5 (PP5), which acts to turn off ASK-1/MKK-4/JNK signaling via two mechanisms...
  65. Cliff M, Williams M, Brooke Smith J, Barford D, Ladbury J. Molecular recognition via coupled folding and binding in a TPR domain. J Mol Biol. 2005;346:717-32 pubmed
    ..This function is exemplified by the TPR domain of protein phosphatase 5 (PP5), which binds to the C terminus of the chaperone protein Hsp90...
  66. Hashem R, Hassanin K, Rashed L, Mahmoud M, Hassan M. Effect of silibinin and vitamin E on the ASK1-p38 MAPK pathway in D-galactosamine/lipopolysaccharide induced hepatotoxicity. Exp Biol Med (Maywood). 2016;241:1250-7 pubmed publisher
    ..the negative modulators of ASK1, thioredoxin1 (Trx1), thioredoxin reductase1 (TrxR1), and the protein phosphatase (PP5), whereas they have previously proven to have hepatoprotective effect...
  67. Zhang Y, Leung D, Nordeen S, Goleva E. Estrogen inhibits glucocorticoid action via protein phosphatase 5 (PP5)-mediated glucocorticoid receptor dephosphorylation. J Biol Chem. 2009;284:24542-52 pubmed publisher
    ..We show that estrogen increases expression of protein phosphatase 5 (PP5), which mediates the dephosphorylation of GR at Ser-211...
  68. Choy M, Swingle M, D Arcy B, Abney K, Rusin S, Kettenbach A, et al. The PP1:tautomycetin complex reveals a path towards the development of PP1-specific inhibitors. J Am Chem Soc. 2017;: pubmed publisher
    ..Together, these data provide the key molecular insights needed for the development of novel probes targeting single PPPs, especially PP1...
  69. Urban G, Golden T, Aragon I, Cowsert L, Cooper S, Dean N, et al. Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression. J Biol Chem. 2003;278:9747-53 pubmed
    Serine/threonine phosphatase 5 (PP5) can act as a suppresser of p53-dependent growth suppression and has been reported to associate with several proteins, including the glucocorticoid receptor/heat-shock protein-90 complex...
  70. Kucej M, Fermaintt C, Yang K, Irizarry Caro R, Yan N. Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex. Cell Rep. 2017;18:2600-2607 pubmed publisher
    ..Thus, the cell-cycle-dependent post-translation modification of TREX1 regulates its interaction with OST, which may have important implications for immune disease associated with the DNase-independent function of TREX1. ..
  71. Golden T, Aragon I, Rutland B, Tucker J, Shevde L, Samant R, et al. Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer. Biochim Biophys Acta. 2008;1782:259-70 pubmed publisher
    Ser/Thr protein phosphatase 5 (PP5) regulates several signaling-cascades that suppress growth and/or facilitate apoptosis in response to genomic stress...
  72. Chatterjee A, Wang L, Armstrong D, Rossie S. Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro. J Biol Chem. 2010;285:3872-82 pubmed publisher
    Physiological studies of ion channel regulation have implicated the Ser/Thr protein phosphatase 5 (PP5) as an effector of Rac1 GTPase signaling, but direct biochemical evidence for PP5 regulation by Rac1 is lacking...
  73. Wang J, Zhu J, Dong M, Yu H, Dai X, Li K. Inhibition of protein phosphatase 5 (PP5) suppresses survival and growth of colorectal cancer cells. Biotechnol Appl Biochem. 2015;62:621-7 pubmed publisher
    Protein phosphatase 5 (PP5) is a unique member of the protein phosphatases family that functions in multiple signaling pathways involved in DNA damage, cell cycle control, cell growth, and apoptosis...
  74. Chen M, McPartlin A, Brown L, Chen Y, Barker H, Cohen P. A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. EMBO J. 1994;13:4278-90 pubmed
    A novel human protein serine/threonine phosphatase, PP5, and a structurally related phosphatase in Saccharomyces cerevisiae, PPT1, have been identified from their cDNA and gene respectively...
  75. Swingle M, Honkanen R, Ciszak E. Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5. J Biol Chem. 2004;279:33992-9 pubmed
    Serine/threonine protein phosphatase-5 (PP5) affects many signaling networks that regulate cell growth and cellular responses to stress. Here we report the crystal structure of the PP5 catalytic domain (PP5c) at a resolution of 1.6 A...
  76. Yamaguchi F, Umeda Y, Shimamoto S, Tsuchiya M, Tokumitsu H, Tokuda M, et al. S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation. J Biol Chem. 2012;287:13787-98 pubmed publisher
    b>PP5 is a unique member of serine/threonine phosphatases comprising a regulatory tetratricopeptide repeat (TPR) domain and functions in signaling pathways that control many cellular responses...
  77. Taira J, Higashimoto Y. Caveolin-1 interacts with protein phosphatase 5 and modulates its activity in prostate cancer cells. Biochem Biophys Res Commun. 2013;431:724-8 pubmed publisher
    ..Here, we identified protein phosphatase 5 (PP5) as a novel cellular binding partner of caveolin-1 using a pull-down approach in combination with mass spectrometry-..
  78. Xu X, Lagercrantz J, Zickert P, Bajalica Lagercrantz S, Zetterberg A. Chromosomal localization and 5' sequence of the human protein serine/threonine phosphatase 5' gene. Biochem Biophys Res Commun. 1996;218:514-7 pubmed
    ..Protein phosphatase 5 (PP5) is a novel member of the protein serine/threonine phosphatase family...
  79. Amable L, Grankvist N, Largen J, Ortsäter H, Sjoholm A, Honkanen R. Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1). J Biol Chem. 2011;286:40413-22 pubmed publisher
    b>PP5 is a ubiquitously expressed Ser/Thr protein phosphatase. High levels of PP5 have been observed in human cancers, and constitutive PP5 overexpression aids tumor progression in mouse models of tumor development...
  80. Chachi L, Abbasian M, Gavrila A, Alzahrani A, Tliba O, Bradding P, et al. Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma. Allergy. 2017;72:126-136 pubmed publisher
    ..Immunohistochemistry and flow cytometry assays were used to assess the expression of the protein phosphatase PP5 in endobronchial biopsies and ASM cells...
  81. Pazdrak K, Straub C, Maroto R, Stafford S, White W, Calhoun W, et al. Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling. J Immunol. 2016;197:3782-3791 pubmed
    ..and resistant eosinophils identified several differentially expressed proteins, namely protein phosphatase 5 (PP5), formyl peptide receptor 2, and annexin 1...
  82. Sharabi A, Kasper I, Tsokos G. The serine/threonine protein phosphatase 2A controls autoimmunity. Clin Immunol. 2018;186:38-42 pubmed publisher
    ..Targeting PP2A in T cell subsets may be therapeutic for SLE and other autoimmune diseases. ..
  83. Heck K, Alvarenga D, Shishido T, Varani A, Dörr F, Pinto E, et al. Biosynthesis of microcystin hepatotoxins in the cyanobacterial genus Fischerella. Toxicon. 2018;141:43-50 pubmed publisher
    ..To our knowledge, this study presents the first complete mcy cluster characterization from a strain of the genus Fischerella, providing new insight into the distribution and evolution of MCs in the phylum Cyanobacteria. ..
  84. Yang J, Roe S, Cliff M, Williams M, Ladbury J, Cohen P, et al. Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. EMBO J. 2005;24:1-10 pubmed
    Protein phosphatase 5 (Ppp5) is a serine/threonine protein phosphatase comprising a regulatory tetratricopeptide repeat (TPR) domain N-terminal to its phosphatase domain...
  85. Cliff M, Harris R, Barford D, Ladbury J, Williams M. Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90. Structure. 2006;14:415-26 pubmed
    Protein phosphatase 5 (Ppp5) is one of several proteins that bind to the Hsp90 chaperone via a tetratricopeptide repeat (TPR) domain...
  86. Chawla S, Kundu D, Randhawa A, Mondal A. The serine/threonine phosphatase DhSIT4 modulates cell cycle, salt tolerance and cell wall integrity in halo tolerant yeast Debaryomyces hansenii. Gene. 2017;606:1-9 pubmed publisher
    ..Our study also demonstrated the antagonistic roles of DhSit4p and DhPpz1p in maintaining the cell cycle and ion homeostasis in D. hansenii. ..
  87. Klötgen H, Beltraminelli H, Yawalkar N, van Gijn M, Holzinger D, Borradori L. The expanding spectrum of clinical phenotypes associated with PSTPIP1 mutations: from PAPA to PAMI syndrome and beyond. Br J Dermatol. 2017;: pubmed publisher
    ..sup>3 A 23-year-old man had a 3-year-history of skin ulcerations. This article is protected by copyright. All rights reserved...
  88. Silverstein A, Galigniana M, Chen M, Owens Grillo J, Chinkers M, Pratt W. Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. J Biol Chem. 1997;272:16224-30 pubmed
    ..We have recently reported that a protein serine/threonine phosphatase that is designated PP5 and contains four TPRs binds to hsp90 and is co-purified with the glucocorticoid receptor (GR) (Chen, M.-S...
  89. von Kriegsheim A, Pitt A, Grindlay G, Kolch W, Dhillon A. Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5. Nat Cell Biol. 2006;8:1011-6 pubmed
    ..Protein phosphatase 5 (PP5) was identified as an inactivator that associates with Raf-1 on growth factor stimulation and selectively ..
  90. O Connor C, Perl A, Leonard D, Sangodkar J, Narla G. Therapeutic targeting of PP2A. Int J Biochem Cell Biol. 2018;96:182-193 pubmed publisher
  91. Shah B, Catt K. Protein phosphatase 5 as a negative key regulator of Raf-1 activation. Trends Endocrinol Metab. 2006;17:382-4 pubmed
    ..Recently, protein phosphatase 5 has been characterized as a key dephosphorylation regulator of Raf-1 activation in growth factor-mediated signaling, leading to attenuation of the MEK-ERK cascade. ..
  92. Buvall L, Wallentin H, Sieber J, Andreeva S, Choi H, Mundel P, et al. Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes. J Am Soc Nephrol. 2017;28:837-851 pubmed publisher
    ..Our studies reveal how synaptopodin, a single proteolytically-controlled protein, integrates antagonistic tyrosine versus serine/threonine phosphorylation events for the dynamic control of the actin cytoskeleton in podocytes. ..