PPP2R2C

Summary

Gene Symbol: PPP2R2C
Description: protein phosphatase 2, regulatory subunit B, gamma
Alias: B55-GAMMA, IMYPNO, IMYPNO1, PR52, PR55G, PP2A, subunit B, B-gamma isoform, PP2A, subunit B, B55-gamma isoform, PP2A, subunit B, PR55-gamma isoform, PP2A, subunit B, R2-gamma isoform, gamma isoform of regulatory subunit B55, protein phosphatase 2, phosphoprotein phosphatase 2A BR gamma regulatory chain, protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform, protein phosphatase 2A1 B gamma subunit, serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Species: human

Top Publications

  1. ncbi Type 2A protein phosphatase, the complex regulator of numerous signaling pathways
    S Zolnierowicz
    Intercollegiate Faculty of Biotechnology UG MUG, Gdansk, Poland
    Biochem Pharmacol 60:1225-35. 2000
  2. pmc Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription
    Tatyana Ammosova
    Center for Sickle Cell Disease, Howard University, 2121 Georgia Ave, N W Washington, DC 20059, USA
    Retrovirology 2:47. 2005
  3. pmc The Vpr protein from HIV-1: distinct roles along the viral life cycle
    Erwann Le Rouzic
    Institut Cochin, Department of Infectious Diseases, INSERM U567, CNRS UMR8104, Universite Paris 5, Paris, France
    Retrovirology 2:11. 2005
  4. ncbi Regulation of HIV-1 transcription by protein phosphatase 1
    Sergei Nekhai
    Center for Sickle Cell Disease, Howard University, Washington, DC 20059, USA
    Curr HIV Res 5:3-9. 2007
  5. pmc Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A
    M Hrimech
    Laboratoire de Rétrovirologie Humaine, Departement de Microbiologie et Immunologie, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    EMBO J 19:3956-67. 2000
  6. ncbi HIV-1 viral protein R (Vpr) & host cellular responses
    Richard Yuqi Zhao
    Department of Pathology, University of Maryland School of Medicine, 10 South Pine Street, MSTF 600, Baltimore, MD 21201, USA
    Indian J Med Res 121:270-86. 2005
  7. ncbi Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production
    R Ruediger
    Department of Pathology, University of California at San Diego, La Jolla 92093 0612, USA
    Virology 238:432-43. 1997
  8. ncbi Activation of protein phosphatase-2A1 by HIV-1 Vpr cell death causing peptide in intact CD(4+) T cells and in vitro
    Anwar Janoo
    Protein and Nucleic Acids Chemistry Laboratory, Norchit Biomedical Research Institute, Liverpool Syracuse 13088, New York, NY, USA
    J Cell Biochem 94:816-25. 2005
  9. ncbi The role of Vpr in HIV-1 pathogenesis
    Joshua L Andersen
    Division of Cellular Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Curr HIV Res 3:43-51. 2005
  10. doi Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway
    Yi Ling Fan
    Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
    FEBS Lett 587:3892-7. 2013

Research Grants

Scientific Experts

  • Yonghong Peng
  • Christian Jacob
  • Erwann Le Rouzic
  • Tatyana Ammosova
  • Richard Yuqi Zhao
  • H Y Tung
  • S Zolnierowicz
  • Maged Al-Sherbiny
  • S Kim
  • Sergei Nekhai
  • Wanting Liu
  • Eric G Bluemn
  • Yi Ling Fan
  • Can Hasdemir
  • Liesbeth Backx
  • Jun Wang
  • Meisheng Zhou
  • Johan Rung
  • Gregory A Barker
  • Karl D Murray
  • A K Banerjee
  • Pieter J A Eichhorn
  • M Borsotto
  • Krishnaraj Rajalingam
  • Joshua L Andersen
  • Anwar Janoo
  • Wen Chen
  • David C Pallas
  • Jack F Shern
  • E M G Campbell
  • Alexey S Kutsenko
  • James Annis
  • Peter S Nelson
  • Ryan R Gordon
  • Daniel Lewinshtein
  • Elysia Sophie Spencer
  • Jie Qing Wan
  • Xiaotun Zhang
  • Carla Grandori
  • Ilsa Coleman
  • Elahe Mostaghel
  • Ji Wang
  • Qing Yao
  • Desmond J Tobin
  • Christopher Porter
  • Lei Chen
  • Brigham Mecham
  • Thomy de Ravel
  • Joris Vermeesch
  • Hikmet H Aydin
  • P Hu
  • Mehmet Aydin
  • Eve Seuntjens
  • Meral Kayikcioglu
  • Serdar Payzin
  • Elly Pijkels
  • Hilde Van Esch
  • Levent H Can
  • Hakan Kultursay
  • Handan A Celik
  • M Hrimech
  • Evrim Simsek
  • Marjo Riitta Jarvelin
  • David Serre
  • Christian Dina
  • Emmanuelle Durand
  • Won Kyung Cho
  • Anneli Pouta
  • Anders Albrechtsen
  • Philippe Froguel
  • Stephane Cauchi
  • Fatah Kashanchi
  • François Bacot
  • Constantin Polychronakos
  • Alexandre Belisle
  • Jean Tichet
  • Alexander Mazur
  • Torsten Lauritzen
  • Barry Posner
  • Martine Vaxillaire
  • Aimo Ruokonen
  • Lishuang Shen
  • Torben Hansen
  • Marc Prentki
  • Ghislain Rocheleau
  • Knut Borch-Johnsen
  • Michel Marre
  • Zach Klase
  • John N Brady
  • Guillaume Charpentier

Detail Information

Publications36

  1. ncbi Type 2A protein phosphatase, the complex regulator of numerous signaling pathways
    S Zolnierowicz
    Intercollegiate Faculty of Biotechnology UG MUG, Gdansk, Poland
    Biochem Pharmacol 60:1225-35. 2000
    ..Thus, a more thorough understanding of PP2A structure and function may lead to the development of novel strategies against human diseases...
  2. pmc Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription
    Tatyana Ammosova
    Center for Sickle Cell Disease, Howard University, 2121 Georgia Ave, N W Washington, DC 20059, USA
    Retrovirology 2:47. 2005
    ..In the present study we analyze relative contribution of PP2A and PP1 to dephosphorylation of CDK9 and to HIV-1 transcription in vitro and in vivo...
  3. pmc The Vpr protein from HIV-1: distinct roles along the viral life cycle
    Erwann Le Rouzic
    Institut Cochin, Department of Infectious Diseases, INSERM U567, CNRS UMR8104, Universite Paris 5, Paris, France
    Retrovirology 2:11. 2005
    ..In this review, we will mainly focus on vpr from HIV-1 and discuss the most recent developments in our understanding of Vpr functions and its role during the virus replication cycle...
  4. ncbi Regulation of HIV-1 transcription by protein phosphatase 1
    Sergei Nekhai
    Center for Sickle Cell Disease, Howard University, Washington, DC 20059, USA
    Curr HIV Res 5:3-9. 2007
    ..We also present a computer model of Tat-PP1 complex that might be useful for future drug design in anti-HIV-1 therapeutics...
  5. pmc Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A
    M Hrimech
    Laboratoire de Rétrovirologie Humaine, Departement de Microbiologie et Immunologie, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    EMBO J 19:3956-67. 2000
    ..Our data suggest that Vpr mediates G(2) arrest by enhancing the nuclear import of PP2A and by positively modulating its catalytic activity towards active phosphorylated nuclear cdc25...
  6. ncbi HIV-1 viral protein R (Vpr) & host cellular responses
    Richard Yuqi Zhao
    Department of Pathology, University of Maryland School of Medicine, 10 South Pine Street, MSTF 600, Baltimore, MD 21201, USA
    Indian J Med Res 121:270-86. 2005
    ..Strategies with potential application for future antiviral therapies directed at suppressing Vpr activities are described...
  7. ncbi Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production
    R Ruediger
    Department of Pathology, University of California at San Diego, La Jolla 92093 0612, USA
    Virology 238:432-43. 1997
    ..These results demonstrate that the balance between PP2A holoenzyme and core enzyme is important for HIV-1 gene expression and virus production...
  8. ncbi Activation of protein phosphatase-2A1 by HIV-1 Vpr cell death causing peptide in intact CD(4+) T cells and in vitro
    Anwar Janoo
    Protein and Nucleic Acids Chemistry Laboratory, Norchit Biomedical Research Institute, Liverpool Syracuse 13088, New York, NY, USA
    J Cell Biochem 94:816-25. 2005
    ....
  9. ncbi The role of Vpr in HIV-1 pathogenesis
    Joshua L Andersen
    Division of Cellular Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Curr HIV Res 3:43-51. 2005
    ..This review presents the latest findings about the pathogenic events triggered by Vpr, the cellular pathways involved, and the molecular and cellular consequences of the action of Vpr in the context of HIV-1 infection...
  10. doi Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway
    Yi Ling Fan
    Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
    FEBS Lett 587:3892-7. 2013
    b>PPP2R2C encodes a gamma isoform of the subunit B55 subfamily, which is a regulatory subunit of Protein phosphatase type 2A (PP2A). Our study shows that PPP2R2C is downregulated in glioma cells and human brain cancer patient samples...
  11. pmc PPP2R2C loss promotes castration-resistance and is associated with increased prostate cancer-specific mortality
    Eric G Bluemn
    School of Medicine, University of Washington, Seattle, Washington, USA
    Mol Cancer Res 11:568-78. 2013
    ..complex: PPP2R1A, a structural subunit with known tumor-suppressor properties in several tumor types; and PPP2R2C, a PP2A substrate-binding regulatory subunit that has not been previously identified as a tumor suppressor...
  12. pmc Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29
    Meisheng Zhou
    Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 83:1036-44. 2009
    ..Finally, we present chromatin immunoprecipitation studies showing that CDK9 with phosphorylated T29 is associated with the HIV promoter region in the integrated and transcriptionally silent HIV genome...
  13. pmc A new 12-gene diagnostic biomarker signature of melanoma revealed by integrated microarray analysis
    Wanting Liu
    Department of Computing, University of Bradford, Great Britain Centre of Skin Sciences, University of Bradford, Great Britain
    Peerj 1:e49. 2013
    ..e., EGFR, FGFR2, FGFR3, IL8, PTPRF, TNC, CXCL13, COL11A1, CHP2, SHC4, PPP2R2C, and WNT4)...
  14. ncbi [Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors]
    Jun Wang
    Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China
    Yao Xue Xue Bao 44:1343-7. 2009
    ..In this review, we discuss the action of PP1 in Tat-induced HIV-1 transcription and related to PP1 inhibitors...
  15. doi PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD
    Christian Jacob
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Atten Defic Hyperact Disord 4:145-52. 2012
    ..One of the most promising candidate genes in this region is protein phosphatase 2, regulatory subunit B, gamma (PPP2R2C), which, however, thus far has not been assessed for a potential association with ADHD...
  16. pmc A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC
    Pieter J A Eichhorn
    Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    PLoS Genet 3:e218. 2007
    ..Our data reveal a novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55gamma...
  17. pmc RNA interference screen to identify pathways that enhance or reduce nonviral gene transfer during lipofection
    Gregory A Barker
    Penn Center for Molecular Discovery, Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Ther 16:1602-8. 2008
    ..The best candidate siRNA targeted the PPP2R2C gene and produced a 65% increase in luminescence from lipofection, with a quantitative PCR-validated knockdown of ..
  18. doi Transcriptional profiling of septal wall of the right ventricular outflow tract in patients with idiopathic ventricular arrhythmias
    Can Hasdemir
    Department of Cardiology, Ege University School of Medicine, Bornova, Izmir, Turkey
    Pacing Clin Electrophysiol 33:159-67. 2010
    ..The aim of this study was to investigate the genome-wide transcriptional profiling of the septal wall of the RVOT in patients with RVOT tachycardia and control subjects...
  19. doi PPP2R2C, a gene disrupted in autosomal dominant intellectual disability
    Liesbeth Backx
    Centre for Human Genetics, University Hospital Leuven, Leuven, Belgium
    Eur J Med Genet 53:239-43. 2010
    ..1;q22) that segregates with mild ID, epilepsy and behavioural problems and that disrupts the PPP2R2C gene on chromosome 4p...
  20. pmc Molecular correlates of laminar differences in the macaque dorsal lateral geniculate nucleus
    Karl D Murray
    Center for Neuroscience and Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California 95616, USA
    J Neurosci 28:12010-22. 2008
    ..of which 10 were enriched in magnocellular layers (BRD4, CAV1, EEF1A2, FAM108A1, INalpha, KCNA1, NEFH, NEFL, PPP2R2C, and SFRP2) and one was enriched in parvocellular and koniocellular layers (TCF7L2)...
  21. doi Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders
    S Kim
    Stanley Brain Research Laboratory, Stanley Medical Research Institute, Rockville, MD 20850, USA
    Mol Psychiatry 16:452-61. 2011
    ..Moreover, the susceptibility gene for bipolar disorder, PPP2R2C, was found to be associated with the number of perineuronal oligodendrocytes...
  22. doi Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
    Johan Rung
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Nat Genet 41:1110-5. 2009
    ....
  23. ncbi Clonal divergence in lung cancer development is associated with allelic loss on chromosome 4
    A K Banerjee
    Department of Thoracic Medicine, University College London Hospitals, London, UK
    Genes Chromosomes Cancer 46:852-60. 2007
    ..six genes including two candidate tumor suppressor genes, CRMP1 a lung cancer metastasis-suppressing gene and PPP2R2C a gene for a regulatory subunit of the PP2 complex known to suppress tumorigenesis, particularly viral induced ..
  24. ncbi PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder
    M Borsotto
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS Universite de Nice, Institut Paul Hamel, Sophia Antipolis, Valbonne, France
    Pharmacogenomics J 7:123-32. 2007
    ..In this region, the PPP2R2C gene encodes the Bgamma-regulatory subunit of the protein phosphatase 2A (PP2A-Bgamma)...
  25. ncbi Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits
    S Strack
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Comp Neurol 392:515-27. 1998
    ..Bgamma may target PP2A to cytoskeletal substrates that are important in the establishment and maintenance of neuronal connections...
  26. ncbi Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit
    R Torres
    Novartis Pharmaceuticals Corporation, Pharmacogenetics Division, Gaithersburg, MD 20878, USA
    DNA Res 6:323-7. 1999
    ..Here we describe the precise genomic organization and genetic localization of the human PP2ABRgamma gene...
  27. ncbi Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16
    P Hu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, People s Republic of China
    Genomics 67:83-6. 2000
    ..protein shares 81 and 85% identity with B1alpha (PPP2R2A) and B1beta (PPP2R2B), respectively, and was named PPP2R2C for its high level of homology to the other two isoforms...
  28. pmc NotI flanking sequences: a tool for gene discovery and verification of the human genome
    Alexey S Kutsenko
    Center for Genomics and Bioinformatics, Karolinska Institute, 171 77 Stockholm, Sweden
    Nucleic Acids Res 30:3163-70. 2002
    ....
  29. ncbi Fine mapping a quantitative trait locus affecting ovulation rate in swine on chromosome 8
    E M G Campbell
    USDA, ARS, U S Meat Animal Research Center, Clay Center, NE 68933, USA
    J Anim Sci 81:1706-14. 2003
    ..repeats, and informative microsatellite markers were developed for seven genes (GNRHR, IDUA, MAN2B2, MSX1, PDE6B, PPP2R2C, and RGS12)...
  30. ncbi Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A
    Jack F Shern
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:40829-36. 2003
    ..Our data suggest functional roles for the cytosolic Arl2 complex in modulating tubulin and microtubule behavior as well as a possible role in apoptosis...
  31. ncbi In vitro cellular and humoral responses to Schistosoma mansoni vaccine candidate antigens
    Maged Al-Sherbiny
    Department of Zoology, Faculty of Science, Cairo University Egyptian Reference Diagnostic Center ERDC VACSERA, 7 Okba Ibn Nafei F 37, Dokki, Giza, 12311, Cairo, Egypt
    Acta Trop 88:117-30. 2003
    ..native protein (Sm97-paramyosin), two synthetic peptides (MAP3 and MAP4) and three unpublished antigens (PR52-filamin, PL45-phosphoglycerate kinase, PN18-cyclophilin)...
  32. ncbi Identification of specific PP2A complexes involved in human cell transformation
    Wen Chen
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Cell 5:127-36. 2004
    ..These observations identify specific PP2A complexes involved in human cell transformation...
  33. ncbi Viral infections and cell cycle G2/M regulation
    Richard Y Zhao
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 2120, USA
    Cell Res 15:143-9. 2005
    ....
  34. ncbi Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration
    Krishnaraj Rajalingam
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Nat Cell Biol 7:837-43. 2005
    ..Our data show an unexpected role of prohibitin in the activation of the Ras-Raf signalling pathway and in modulating epithelial cell adhesion and migration...
  35. ncbi Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr
    H Y Tung
    Laboratoire de Physiologie de la Reproduction, CNRS URA 1449, INRA, Universite Pierre et Marie Curie, Paris, France
    FEBS Lett 401:197-201. 1997
    ....

Research Grants13

  1. Effect of HIV-1 Vpr on Basic Cellular Functions (II)
    Richard Zhao; Fiscal Year: 2007
    ..abstract_text> ..
  2. Effect of HIV-1 Vpr on Basic Cellular Functions (II)
    Richard Zhao; Fiscal Year: 2006
    ..abstract_text> ..
  3. Cell Cycle G2/M Pathway Modulated by Viral Protein R
    Richard Zhao; Fiscal Year: 2006
    ..These proposed studies will provide a comprehensive framework for this new cell cycle control pathway and provide insights into fundamental aspects of this new G2/M surveillance system of eukaryotic cells. ..
  4. Effect of HIV-1 Vpr on Basic Cellular Functions (II)
    Richard Zhao; Fiscal Year: 2003
    ..abstract_text> ..