PPP1R13L

Summary

Gene Symbol: PPP1R13L
Description: protein phosphatase 1 regulatory subunit 13 like
Alias: IASPP, NKIP1, RAI, RAI4, relA-associated inhibitor, NFkB interacting protein 1, PPP1R13B-like protein, inhibitor of ASPP protein, inhibitor of apoptosis stimulating protein of p53, protein iASPP, protein phosphatase 1, regulatory (inhibitor) subunit 13 like, retinoic acid induced 4
Species: human
Products:     PPP1R13L

Top Publications

  1. Zhang X, Diao S, Rao Q, Xing H, Liu H, Liao X, et al. Identification of a novel isoform of iASPP and its interaction with p53. J Mol Biol. 2007;368:1162-71 pubmed
    b>iASPP is an inhibitory member of ASPP (apoptosis stimulating protein of p53, or Ankyrin repeats, SH3 domain and proline-rich region contain Protein) family...
  2. Liu Z, Cai Y, Hou L, Gao X, Xin H, Lu X, et al. Effect of RNA interference of iASPP on the apoptosis in MCF-7 breast cancer cells. Cancer Invest. 2008;26:878-82 pubmed publisher
    ASPP family is proved to be apoptotic specific regulators of p53. Among them, iASPP acts as an inhibitor of p53...
  3. Nexø B, Vogel U, Olsen A, Nyegaard M, Bukowy Z, Rockenbauer E, et al. Linkage disequilibrium mapping of a breast cancer susceptibility locus near RAI/PPP1R13L/iASPP. BMC Med Genet. 2008;9:56 pubmed publisher
    ..Studying one marker at a time, we found a region spanning the gene RAI (alias PPP1R13L or iASPP) and the 5' portion of XPD to be associated with this cancer...
  4. Takada N, Sanda T, Okamoto H, Yang J, Asamitsu K, Sarol L, et al. RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions. J Virol. 2002;76:8019-30 pubmed
    RelA-associated inhibitor (RAI) is an inhibitor of nuclear factor kappaB (NF-kappaB) newly identified by yeast two-hybrid screen as an interacting protein of the p65 (RelA) subunit...
  5. Zhang X, Wang M, Zhou C, Chen S, Wang J. The expression of iASPP in acute leukemias. Leuk Res. 2005;29:179-83 pubmed
    Inhibitory member of the ASPP family (iASPP) is an evolutionarily conserved inhibitor of p53, and its expression is upregulated in human breast carcinomas expressing wild-type p53...
  6. Vangsted A, Gimsing P, Klausen T, Nexø B, Wallin H, Andersen P, et al. Polymorphisms in the genes ERCC2, XRCC3 and CD3EAP influence treatment outcome in multiple myeloma patients undergoing autologous bone marrow transplantation. Int J Cancer. 2007;120:1036-45 pubmed
    ..overall survival (OS) of polymorphism in the DNA repair genes ERCC1, ERCC2 and XRCC3, and in the apoptotic genes PPP1R13L and CD3EAP in 348 patients with multiple myeloma undergoing autologous bone marrow transplantation...
  7. Robinson R, Lu X, Jones E, Siebold C. Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73. Structure. 2008;16:259-68 pubmed publisher
    ASPP1 and ASPP2 are activators of p53-dependent apoptosis, whereas iASPP is an inhibitor of p53...
  8. Bergamaschi D, Samuels Y, O Neil N, Trigiante G, Crook T, Hsieh J, et al. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet. 2003;33:162-7 pubmed
    ..Here, we characterize such a protein, iASPP (inhibitory member of the ASPP family), encoded by PPP1R13L in humans and ape-1 in Caenorhabditis elegans...
  9. Lin B, Xie D, Xie S, Xie J, Zhang X, Zhang Y, et al. Down-regulation of iASPP in human hepatocellular carcinoma cells inhibits cell proliferation and tumor growth. Neoplasma. 2011;58:205-10 pubmed
    The oncoprotein inhibitory member of the ASPP family (iASPP) is a key inhibitor of the p53 tumor suppressor and is upregulated in patients with acute leukemia and breast carcinoma...

More Information

Publications94

  1. Laska M, Nexø B, Vistisen K, Poulsen H, Loft S, Vogel U. Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer. Cancer Lett. 2005;225:245-51 pubmed
    ..2-3, encompassing the genes ASE, ERCC1, RAI and XPD, were associated with risk of testicular cancer in Danish patients...
  2. Bergamaschi D, Samuels Y, Sullivan A, Zvelebil M, Breyssens H, Bisso A, et al. iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. Nat Genet. 2006;38:1133-41 pubmed
    b>iASPP is one of the most evolutionarily conserved inhibitors of p53, whereas ASPP1 and ASPP2 are activators of p53...
  3. Su D, Ma S, Liu P, Jiang Z, Lv W, Zhang Y, et al. Genetic polymorphisms and treatment response in advanced non-small cell lung cancer. Lung Cancer. 2007;56:281-8 pubmed
    ..we genotyped four single nucleotide polymorphisms (SNPs) in ATM (A60G), ERCC1 (Asn118Asn), APE1 (Asn148Glu), and iASPP (A67T), and examined their associations with treatment response among patients with advanced non-small cell lung ..
  4. Jiang L, Siu M, Wong O, Tam K, Lu X, Lam E, et al. iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe. Clin Cancer Res. 2011;17:6924-33 pubmed publisher
    b>iASPP is a specific regulator of p53-mediated apoptosis. Herein, we provided the first report on the expression profile of iASPP in ovarian epithelial tumor and its effect on paclitaxel chemosensitivity...
  5. Chen J, Xie F, Zhang L, Jiang W. iASPP is over-expressed in human non-small cell lung cancer and regulates the proliferation of lung cancer cells through a p53 associated pathway. BMC Cancer. 2010;10:694 pubmed publisher
    b>iASPP is a key inhibitor of tumour suppressor p53 and is found to be up-regulated in certain malignant conditions...
  6. Liu Z, Zhang X, Huang D, Liu Y, Zhang X, Liu L, et al. Elevated expression of iASPP in head and neck squamous cell carcinoma and its clinical significance. Med Oncol. 2012;29:3381-8 pubmed publisher
    b>iASPP is shown to be elevated in several cancers. However, the role of iASPP in head and neck squamous cell carcinoma (HNSCC) remains unknown...
  7. Hansen R, Sørensen M, Tjønneland A, Overvad K, Wallin H, Raaschou Nielsen O, et al. A haplotype of polymorphisms in ASE-1, RAI and ERCC1 and the effects of tobacco smoking and alcohol consumption on risk of colorectal cancer: a Danish prospective case-cohort study. BMC Cancer. 2008;8:54 pubmed publisher
    ..The haplotype at chromosome 19q13.2-3 encompassing the three SNPs ASE-1 G-21A, RAI IVS1 A4364G and ERCC1 Asn118Asn have been associated with risk of breast cancer and lung cancer...
  8. Vogel U, Sørensen M, Hansen R, Tjønneland A, Overvad K, Wallin H, et al. Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study. Cancer Lett. 2007;247:159-65 pubmed
    Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn(A), ASE-1 G-21A(G), RAI IVS1 A4364G(A) are at increased risk of lung cancer especially among women...
  9. Laska M, Strandbygård D, Kjeldgaard A, Mains M, Corydon T, Memon A, et al. Expression of the RAI gene is conducive to apoptosis: studies of induction and interference. Exp Cell Res. 2007;313:2611-21 pubmed
    The RAI gene is also known as iASPP and PPP1R13L. Recent investigations have shown that the region encompassing RAI is important for the development of cancer in young and middle-aged persons...
  10. Skjelbred C, Saebø M, Nexø B, Wallin H, Hansteen I, Vogel U, et al. Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study. BMC Cancer. 2006;6:175 pubmed
    ..2-3, encompassing the genes ERCC1, ASE-1 and RAI, and risk of colorectal adenomas and carcinomas in a Norwegian cohort...
  11. Skene Arnold T, Luu H, Uhrig R, De Wever V, Nimick M, Maynes J, et al. Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins. Biochem J. 2013;449:649-59 pubmed publisher
    ..Human ASPPs (apoptosis-stimulating proteins of p53) comprise three family members: ASPP1, ASPP2 and iASPP (inhibitory ASPP), which is uniquely overexpressed in many cancers...
  12. Li S, Shi G, Yuan H, Zhou T, Zhang Q, Zhu H, et al. Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP. Oncol Rep. 2012;28:133-40 pubmed publisher
    ..Recently discovered ASPP1 and ASPP2 are specific activators and iASPP is an inhibitor of p53...
  13. Lu M, Breyssens H, Salter V, Zhong S, Hu Y, Baer C, et al. Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP. Cancer Cell. 2013;23:618-33 pubmed publisher
    ..Here, we identify that cyclin B1/CDK1-phosphorylates iASPP, which leads to the inhibition of iASPP dimerization, promotion of iASPP monomer nuclear entry, and exposure of ..
  14. Li G, Wang R, Gao J, Deng K, Wei J, Wei Y. RNA interference-mediated silencing of iASPP induces cell proliferation inhibition and G0/G1 cell cycle arrest in U251 human glioblastoma cells. Mol Cell Biochem. 2011;350:193-200 pubmed publisher
    b>iASPP is an evolutionally conserved inhibitory member of the ASPP (apoptosis-stimulating protein of p53) protein family...
  15. Yang J, Hori M, Sanda T, Okamoto T. Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor. J Biol Chem. 1999;274:15662-70 pubmed
    Here we report the identification and characterization of a novel protein, RelA-associated inhibitor (RAI), that binds to the NF-kappaB subunit p65 (RelA) and inhibits its transcriptional activity...
  16. Ahn J, Byeon I, Byeon C, Gronenborn A. Insight into the structural basis of pro- and antiapoptotic p53 modulation by ASPP proteins. J Biol Chem. 2009;284:13812-22 pubmed publisher
    ..Its three known members, ASPP1, ASPP2, and iASPP, were previously found to interact with p53, influencing the apoptotic response of cells without affecting p53-..
  17. Herron B, Rao C, Liu S, Laprade L, Richardson J, Olivieri E, et al. A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice. Hum Mol Genet. 2005;14:667-77 pubmed
    ..A C-terminal fragment of this protein was previously identified as the RelA associated inhibitor (RAI)...
  18. Slee E, Gillotin S, Bergamaschi D, Royer C, Llanos S, Ali S, et al. The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization. Oncogene. 2004;23:9007-16 pubmed
    ..b>iASPP(RAI) is a third member of the family that is the most conserved inhibitor of p53-mediated apoptosis...
  19. Zhang B, Xiao H, Chen J, Tao X, Cai L. Inhibitory member of the apoptosis-stimulating protein of p53 (ASPP) family promotes growth and tumorigenesis in human p53-deficient prostate cancer cells. Prostate Cancer Prostatic Dis. 2011;14:219-24 pubmed publisher
    b>iASPP is a member of the apoptosis-stimulating protein of p53 (ASPP) family and an evolutionarily conserved inhibitor of p53...
  20. Chikh A, Matin R, Senatore V, Hufbauer M, Lavery D, Raimondi C, et al. iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. EMBO J. 2011;30:4261-73 pubmed publisher
    b>iASPP, an inhibitory member of the ASPP (apoptosis stimulating protein of p53) family, is an evolutionarily conserved inhibitor of p53 which is frequently upregulated in human cancers...
  21. Abuelgasim K, Rehan H, Alsubaie M, Al Atwi N, Al Balwi M, Alshieban S, et al. Coexistence of chronic myeloid leukemia and diffuse large B-cell lymphoma with antecedent chronic lymphocytic leukemia: a case report and review of the literature. J Med Case Rep. 2018;12:64 pubmed publisher
    ..60-year-old Saudi man known to have diabetes, hypertension, and chronic active hepatitis B was diagnosed as having Rai stage II chronic lymphocytic leukemia, with trisomy 12 and rearrangement of the CCND1 gene in December 2012...
  22. Mazokopakis E. Differentiated thyroid cancer and selenium supplements for protection of salivary glands from 131I treatment. Hell J Nucl Med. 2018;21:83-84 pubmed publisher
    ..of Brazil nut consumption as another choice for the preparation of DTC patients for radioactive iodine (RAI) therapy...
  23. Tsertsvadze T, Mitskevich N, Bilanishvili A, Girdaladze D, Porakishvili N. PHAGOCYTOSIS AND EXPRESSION OF FCg-RECEPTORS AND CD180 ON MONOCYTES IN CHRONIC LYMPHOCYTIC LEUKEMIA. Georgian Med News. 2017;:88-93 pubmed
    ..monocytes of CLL patients, with the drop in CD64 expression correlating with the disease progression and advanced Rai stages. In addition, the treatment with COP led to a more profound decrease in the expression of CD64...
  24. Zhang J, Ma S, Yan C, Zhang S, Liu L, Wang L, et al. Altered coupling of default-mode, executive-control and salience networks in Internet gaming disorder. Eur Psychiatry. 2017;45:114-120 pubmed publisher
    ..and SN-DMN connectivity, as well as in the modulation of ECN versus DMN by SN, using a resource allocation index (RAI) developed and validated previously in nicotine addiction, were assessed...
  25. Betini R, Hirdes J, Lero D, Cadell S, Poss J, Heckman G. A longitudinal study looking at and beyond care recipient health as a predictor of long term care home admission. BMC Health Serv Res. 2017;17:709 pubmed publisher
    ..A total of 94,957 resident assessment instruments-home care (RAI-HC), completed between April 01st 2013 and April 01st, 2014 as part of a clinical practice by 14 Local Health ..
  26. Işıksaçan N, Çınar S, Aktaş Çetin E, Aktan M, Deniz G. Cytokine Contents in Chronic Lymphocytic Leukemia: Association with ZAP70 Expression. Turk J Haematol. 2016;33:202-8 pubmed publisher
    ..IFN-γ) and interleukin-4 (IL-4) content of T, B, and CLL cells in CLL patients and their correlations with Rai staging and ZAP70 positivity were investigated...
  27. Cai W, Chen T, Ide J, Li C, Menon V. Dissociable Fronto-Operculum-Insula Control Signals for Anticipation and Detection of Inhibitory Sensory Cue. Cereb Cortex. 2017;27:4073-4082 pubmed publisher
    ..Although right fronto-operculum-insula (FOI), encompassing the anterior insular cortex (rAI) and inferior frontal cortex (rIFC), involvement in inhibitory control is well established, little is known about ..
  28. See A, Iyer N, Tan N, Teo C, Ng J, Soo K, et al. Distant metastasis as the sole initial manifestation of well-differentiated thyroid carcinoma. Eur Arch Otorhinolaryngol. 2017;274:2877-2882 pubmed publisher
    ..4%) underwent total thyroidectomy with or without neck dissection and adjuvant RAI, while the rest declined surgery. The mean length of follow-up was 40.1 ± 5...
  29. Rybka J, Butrym A, Wrobel T, Jazwiec B, Bogucka Fedorczuk A, Poręba R, et al. The Expression of Toll-Like Receptors in Patients with B-Cell Chronic Lymphocytic Leukemia. Arch Immunol Ther Exp (Warsz). 2016;64:147-150 pubmed publisher
    ..TLR4 mRNA expression was lower in patients with advanced-stage CLL (Rai stages III and IV) than in patients with early stage disease (Rai stages 0-II)...
  30. Deutschmann M, Chin Lenn L, Nakoneshny S, Dort J, Pasieka J, Chandarana S. Practice patterns among thyroid cancer surgeons: implications of performing a prophylactic central neck dissection. J Otolaryngol Head Neck Surg. 2016;45:55 pubmed
    ..how identification of lymph node (LN) metastases should impact the decision to treat with radioactive iodine (RAI)...
  31. Apidechkul T. A 20-year retrospective cohort study of TB infection among the Hill-tribe HIV/AIDS populations, Thailand. BMC Infect Dis. 2016;16:72 pubmed publisher
    ..the information from the rosters of ARV clinics, OPD cards, and laboratory reports from 16 hospitals in Chiang Rai Province, Thailand...
  32. Li J, Liang J, Zhao T, Lin Y. Noninferior response in BRAF(V600E) mutant nonmetastatic papillary thyroid carcinoma to radioiodine therapy. Eur J Nucl Med Mol Imaging. 2016;43:1034-9 pubmed publisher
    ..We investigate the effect of radioactive iodine (RAI) therapy on the clinical outcome in PTC patients with the BRAF(V600E) mutation without distant metastases...
  33. Schierup M, Mailund T, Li H, Wang J, Tjønneland A, Vogel U, et al. Haplotype frequencies in a sub-region of chromosome 19q13.3, related to risk and prognosis of cancer, differ dramatically between ethnic groups. BMC Med Genet. 2009;10:20 pubmed publisher
    A small region of about 70 kb on human chromosome 19q13.3 encompasses 4 genes of which 3, ERCC1, ERCC2, and PPP1R13L (aka RAI) are related to DNA repair and cell survival, and one, CD3EAP, aka ASE1, may be related to cell proliferation...
  34. Napolitano R, De Matteis S, Lucchesi A, Carloni S, Cangini D, Musuraca G, et al. Pentoxifylline-Induced Apoptosis in Chronic Lymphocytic Leukemia: New Insights into Molecular Mechanism. Mini Rev Med Chem. 2017;: pubmed publisher
    ..Methods Peripheral blood mononuclear cells were isolated from 15 CLL patients 0 RAI stage and 15 healthy volunteers and treated for 24 and 48 hours with Pentoxifylline...
  35. De la Fouchardiere C, Oussaïd N, Derbel O, Decaussin Petrucci M, Fondrevelle M, Wang Q, et al. Does Molecular Genotype Provide Useful Information in the Management of Radioiodine Refractory Thyroid Cancers? Results of a Retrospective Study. Target Oncol. 2016;11:71-82 pubmed publisher
    ..number of BRAF-mutant patients, further investigations are required, especially to understand the potential positive effect of BRAF mutations in RAIR TC patients while having a negative prognostic impact in RAI-sensitive PTC patients.
  36. Al Eyadeh A, Al Sarihin K, Etewi S, Al Omari A, Al Asa d R, Haddad F. Thyroid cancer post radioactive iodine treatment for hyperthyroidism - case series and review of the literature. Endokrynol Pol. 2017;68:561-566 pubmed publisher
    To assess the rate of thyroid cancer and mortality rate in a cohort of patients who received RAI¹³¹ treatment for hyperthyroidism and to report the index cases' characteristics and management MATERIAL AND METHODS: A cohort of 264 ..
  37. Xu B, Farhat N, Barletta J, Hung Y, Biase D, Casadei G, et al. Should subcentimeter non-invasive encapsulated, follicular variant of papillary thyroid carcinoma be included in the noninvasive follicular thyroid neoplasm with papillary-like nuclear features category?. Endocrine. 2018;59:143-150 pubmed publisher
    ..mPTC, NI-EFV from five tertiary hospitals who had at least one year clinical follow-up (FU) without post-operative RAI administration were included in the study. A control group of 57 invasive mPTC follicular variant was also included...
  38. Tuttle R, Rondeau G, Lee N. A risk-adapted approach to the use of radioactive iodine and external beam radiation in the treatment of well-differentiated thyroid cancer. Cancer Control. 2011;18:89-95 pubmed
    Both radioactive iodine (RAI) and external beam radiation therapy (EBRT) offer important clinical benefits in properly selected patients with differentiated thyroid cancer...
  39. Mina A, Sandoval Sus J, Sleiman E, Pinilla Ibarz J, Awan F, Kharfan Dabaja M. Using prognostic models in CLL to personalize approach to clinical care: Are we there yet?. Blood Rev. 2018;32:159-166 pubmed publisher
    ..These systems, the Rai and the Binet staging, depended entirely on abnormal exam findings and evidence of anemia and thrombocytopenia...
  40. Larson S, Osborne J, Grewal R, Tuttle R. Redifferentiating Thyroid Cancer: Selumetinib-enhanced Radioiodine Uptake in Thyroid Cancer. Mol Imaging Radionucl Ther. 2017;26:80-86 pubmed publisher
    ..that turned individual thyroid cancer lesions into more efficient tissues for taking up radioactive iodine (RAI), resulting in clinically significant and durable responses...
  41. Lee E, Jeon H, Yoo S, Choi Y, Kang H, Cho S, et al. Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer. Ann Surg Oncol. 2010;17:2608-18 pubmed publisher
    ..Three SNPs (TNFRSF10B rs1047266, TNFRSF1A rs4149570, and PPP1R13L rs1005165) were significantly associated with survival outcomes on multivariate analysis...
  42. Khanijo S, Tandon P, Sison C, Koenig S. Thoracic Complications in Chronic Lymphocytic Leukemia. Clin Lymphoma Myeloma Leuk. 2017;17:220-224 pubmed publisher
    ..The median age was 73 years, with a male to female ratio of 2:1. The majority of patients had a high-risk Rai classification and had received prior treatment...
  43. He Z, Wang Y, Huang G, Wang Q, Zhao D, Chen L. The lncRNA UCA1 interacts with miR-182 to modulate glioma proliferation and migration by targeting iASPP. Arch Biochem Biophys. 2017;623-624:1-8 pubmed publisher
    ..In addition, miR-182 dependent inhibitor of apoptosis-stimulating protein of p53 (iASPP) was required in the regulation of UCA1 induced glioma cell proliferation...
  44. Chan C, Slaughter S, Jones C, Wagg A. Greater Independence in Activities of Daily Living is Associated with Higher Health-Related Quality of Life Scores in Nursing Home Residents with Dementia. Healthcare (Basel). 2015;3:503-18 pubmed publisher
    ..0 (RAI-MDS) and Functional Independence Measure (FIM) instrument...
  45. Côté Bigras S, Tran V, Turcotte S, Rola Pleszczynski M, Verreault J, Rottembourg D. Impaired immune regulation after radioiodine therapy for Graves' disease and the protective effect of Methimazole. Endocrine. 2016;52:587-96 pubmed publisher
    Both therapies for Graves' disease (GD), radioactive iodine (RAI) and antithyroid drugs (ATD), were reported to have specific immune effects...
  46. Bellantone R, Raffaelli M, De Crea C, Sessa L, Traini E, Princi P, et al. Video-Assisted Thyroidectomy for Papillary Thyroid Carcinoma: Oncologic Outcome in Patients with Follow-Up ≥ 10 Years. World J Surg. 2018;42:402-408 pubmed publisher
    ..Among these 153, 62 did not undergo radioiodine ablation (RAI). At a mean follow-up of 150.8 months, mean sTg on LT4 was 0.1 ± 0.1 ng/ml. None of them showed recurrence...
  47. Yokokawa H, Yuasa M, Nedsuwan S, Moolphate S, Fukuda H, Kitajima T, et al. Daily salt intake estimated by overnight urine collections indicates a high cardiovascular disease risk in Thailand. Asia Pac J Clin Nutr. 2016;25:39-45 pubmed publisher
    ..score >15%), who had visited diabetes or hypertension clinics at health centres in the Muang district, Chiang Rai, Thailand...
  48. Kong F, Qi Y, Liu H, Gao F, Yang P, Li Y, et al. Surgery combined with chemotherapy for recurrent gastric cancer achieves better long-term prognosis. Clin Transl Oncol. 2015;17:917-24 pubmed publisher
    ..001). Multivariate analysis indicated TNM stage after the first operation (p = 0.048), iASPP overexpression (p = 0.013), time to recurrence (p < 0...
  49. Ksibi I, Achour R, Bel Haj Ammar W, Cheour M, Ben Amara M, Neji K, et al. [Anti-D prophylaxis in fetal-maternal erythrocyte incompatibility in Tunisia]. Arch Pediatr. 2017;24:942-949 pubmed publisher
    ..In 42 % of the cases, pregnancies were monitored at local clinics. The search for irregular agglutinins (RAI) was performed in 86 % of the women studied. RAI was positive in 97 % of the cases...
  50. Nuutinen M, Leskelä R, Suojalehto E, Tirronen A, Komssi V. Development and validation of classifiers and variable subsets for predicting nursing home admission. BMC Med Inform Decis Mak. 2017;17:39 pubmed publisher
    ..Data were collected from the records of social and health service usage and RAI-HC (Resident Assessment Instrument - Home Care) assessment system during January 2011 and September 2015...
  51. Narayanan S, Colevas A. Current Standards in Treatment of Radioiodine Refractory Thyroid Cancer. Curr Treat Options Oncol. 2016;17:30 pubmed publisher
    Radioiodine refractory differentiated thyroid cancer (RAI-R DTC) is a challenging malignancy with limited prognosis and treatment options...
  52. Spinelli C, Tognetti F, Strambi S, Morganti R, Massimino M, Collini P. Cervical Lymph Node Metastases of Papillary Thyroid Carcinoma, in the Central and Lateral Compartments, in Children and Adolescents: Predictive Factors. World J Surg. 2018;42:2444-2453 pubmed publisher
    ..The presence of LNM in CC has an impact on disease/progression/relapse-free survival. We suggest performing RAI therapy and an accurate follow-up for pediatric patients with only post-operative predictors.
  53. Tay W, Tong A, Hui K, Tang Y, Chng C. Radioiodine associated de novo Graves' opthalmopathy in an Asian cohort. Hell J Nucl Med. 2017;20:227-231 pubmed publisher
    ..In this report, we describe five individuals who required extensive ophthalmic treatment for post-RAI de novo GO.
  54. Woodard C, Liao G, Goodwin C, Hu J, Xie Z, Dos Reis T, et al. A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP. J Virol. 2015;89:9232-41 pubmed publisher
    ..Two of these, SMAD4 and iASPP, were selected for further analysis and were confirmed as ERK-primed GSK-3 substrates...
  55. Hanley O, Lotfi A, Sanborn T, Friderici J, Fitzgerald J, Manikantan P, et al. Radiologists' Recommendations for Additional Imaging on Inpatient CT Studies: Do Referring Physicians Follow Them?. South Med J. 2017;110:770-774 pubmed publisher
    Studies have found that recommendations for additional imaging (RAI) accompany up to 31% of index computed tomography (CT) scans...
  56. Gąsior Perczak D, Pałyga I, Szymonek M, Kowalik A, Walczyk A, Kopczynski J, et al. Delayed risk stratification system in pT1aN0/Nx DTC patients treated without radioactive iodine. Endocr Connect. 2017;6:522-527 pubmed publisher
    ..monitor the clinical outcomes of differentiated thyroid cancer (DTC) patients treated without radioactive iodine (RAI). The aim of this study was to evaluate the DRS system in patients with pT1aN0/Nx stage...
  57. Tomari K, Goto M, Shimada A, Yagi H, Nagashima Y, Hasegawa Y. Five cases of childhood-onset Graves' disease treated with either surgery or radio-iodine therapy. Clin Pediatr Endocrinol. 2017;26:265-269 pubmed publisher
    ..options for the treatment of Graves' disease (GD): antithyroid drugs (ATDs), thyroidectomy, and radio-iodine (RAI) therapy. ATDs are the initial treatment option for children...
  58. Vangsted A, Klausen T, Gimsing P, Andersen N, Abildgaard N, Gregersen H, et al. A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support. Haematologica. 2009;94:1274-81 pubmed publisher
    ..We tested the polymorphisms IL1B T-31C, IL6 G-174C, NFKB1-94ins/delATTG, CD3EAP G-21A and PPP1R13L IVS1 A4364G for associations with time to treatment failure and overall survival with and without interferon-..
  59. Hong B, Liu H, Wang Z, Zhu Y, Su L, Zhang M, et al. Inflammasome activation involved in early inflammation reaction after liver transplantation. Immunol Lett. 2017;190:265-271 pubmed publisher
    ..Our results showed that the rejection activity index (RAI) of Ac-YVAD-CMK-treated allografts is significantly diminished in similar magnitude to that of isografts...
  60. Kramer D, Schön M, Bayerlová M, Bleckmann A, Schön M, Zörnig M, et al. A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity. Cell Death Dis. 2015;6:e1634 pubmed publisher
    ..Here, we investigated the impact of the supposedly inhibitory member of the apoptosis-stimulating protein of p53, iASPP, on the activity of the p53 homolog TAp73, and its cofactors p300 and CBP...
  61. Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, et al. iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. Proc Natl Acad Sci U S A. 2015;112:E973-81 pubmed publisher
    ..5. iASPP-deficient mice with exon 8 deletion (Ppp1r13l(Δ8/Δ8)) die of sudden cardiac death, displaying features of ARVC...
  62. Giguere R, Rael C, Sheinfil A, BALAN I, Brown W, Ho T, et al. Factors Supporting and Hindering Adherence to Rectal Microbicide Gel Use with Receptive Anal Intercourse in a Phase 2 Trial. AIDS Behav. 2018;22:388-401 pubmed publisher
    ..gel trial, participants discussed applicator-inserted gel use in the context of receptive anal intercourse (RAI) with adherence counselors...
  63. Molenaar R, Pleyer C, Radivoyevitch T, Sidana S, Godley A, Advani A, et al. Risk of developing chronic myeloid neoplasms in well-differentiated thyroid cancer patients treated with radioactive iodine. Leukemia. 2017;: pubmed publisher
    ..but such risks are not known in well-differentiated thyroid cancer (WDTC) patients treated with radioactive iodine (RAI)...
  64. Dong P, Xiong Y, Watari H, Hanley S, Konno Y, Ihira K, et al. Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124. Sci Rep. 2016;6:35480 pubmed publisher
    Derepression of wild-type p53 by suppressing its negative inhibitor iASPP (Inhibitor of apoptosis-stimulating protein of p53) represents a potential therapeutic option for cervical cancer (CC)...
  65. Salvatore B, Klain M, Nicolai E, D Amico D, De Matteis G, Raddi M, et al. Prognostic role of FDG PET/CT in patients with differentiated thyroid cancer treated with 131-iodine empiric therapy. Medicine (Baltimore). 2017;96:e8344 pubmed publisher
    ..of F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with differentiated thyroid carcinoma (DTC) undergoing empiric radioiodine (RAI) therapy due to raising values of thyroglobulin (Tg).
  66. Minekawa R, Sakata M, Okamoto Y, Hayashi M, Isobe A, Takeda T, et al. Involvement of RelA-associated inhibitor in regulation of trophoblast differentiation via interaction with transcriptional factor specificity protein-1. Endocrinology. 2007;148:5803-10 pubmed
    ..RelA-associated inhibitor (RAI) is an inhibitor of nuclear factor-kappaB that was identified by a yeast two-hybrid screen and is preferably ..
  67. Manito N, Kaplinsky E, Roca J, Fernandez de Sevilla A, Castells E, Esplugas E. Heart transplantation and chronic lymphocytic leukemia: a successful case at 2 years of follow-up. J Heart Lung Transplant. 2004;23:777-9 pubmed
    ..cardiac transplant in a 52-year-old man who, together with a B-cell chronic lymphocytic leukemia (Binet Stage A, Rai Stage 1), also had end-stage dilated idiopathic myocardiopathy...
  68. Liu K, Zhao H, Yao H, Lei S, Lei Z, Li T, et al. MicroRNA-124 regulates the proliferation of colorectal cancer cells by targeting iASPP. Biomed Res Int. 2013;2013:867537 pubmed publisher
    ..We identified and confirmed inhibitor of apoptosis-stimulating protein of p53 (iASPP) as a novel, direct target of miR-124 using target prediction algorithms and luciferase reporter gene assays...
  69. Lu W, Yu T, Liu S, Li S, Li S, Liu J, et al. FHL2 interacts with iASPP and impacts the biological functions of leukemia cells. Oncotarget. 2017;8:40885-40895 pubmed publisher
    b>iASPP is an inhibitory member of apoptosis-stimulating proteins of p53 (ASPP) family, which inhibits p53-dependent apoptosis. iASPP was highly expressed in acute leukemia, inhibited leukemia cells apoptosis and promoted leukemogenesis...
  70. Yin J, Wang H, Vogel U, Wang C, Hou W, Ma Y. Association and interaction of NFKB1 rs28362491 insertion/deletion ATTG polymorphism and PPP1R13L and CD3EAP related to lung cancer risk in a Chinese population. Tumour Biol. 2016;37:5467-73 pubmed publisher
    ..associations of NFKB1 rs28362491 polymorphism and interactions of this single-nucleotide polymorphism (SNP) and PPP1R13L and CD3EAP and smoking duration in relation to lung cancer risk in a Chinese population...
  71. Frasca T, Giguere R, Ibitoye M, Dolezal C, Febo I, Cranston R, et al. Lessons for Rectal Microbicide Development From an Acceptability Trial of a Placebo Gel Applied Prior to Receptive Anal Intercourse. Arch Sex Behav. 2017;46:1101-1109 pubmed publisher
    ..we recruited 124 young men who have sex with men (YMSM) with a history of unprotected receptive anal intercourse (RAI) and provided them with 40 rectal applicators containing a placebo gel to use prior to RAI during a 12-week period ..
  72. Lu M, Zak J, Chen S, Sanchez Pulido L, Severson D, Endicott J, et al. A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway. Cell. 2014;157:1130-45 pubmed publisher
    ..The RaDAR (RanGDP/AR) pathway represents a general importin-independent nuclear import pathway and is frequently used by AR-containing transcriptional regulators, especially those regulating NF-?B/p53. ..
  73. Acquaviva F, Sana M, Della Monica M, Pinelli M, Postorivo D, Fontana P, et al. First evidence of Smith-Magenis syndrome in mother and daughter due to a novel RAI mutation. Am J Med Genet A. 2017;173:231-238 pubmed publisher
    ..Our experience confirms the importance of searching for alternative causative genetic mechanisms in case of confounding/inconclusive findings such as a CGH-array result of uncertain significance. © 2016 Wiley Periodicals, Inc. ..
  74. Hou W, Yin J, Vogel U, Sun Z, Liang D. 19p13.3-GADD45B common variants and 19q13.3-PPP1R13L and 19q13.3-CD3EAP in lung cancer risk among Chinese. Chem Biol Interact. 2017;277:74-78 pubmed publisher
    ..3-GADD45B and interaction of 19p13.3-GADD45B and 19q13.3-PPP1R13L and 19q13.3-CD3EAP variants and smoking-duration were explored...
  75. Sadic M, Aydinbelge F, Yumusak N, Karakok E, Akbulut A, Koca G, et al. Radioprotective effect of lycopene on the gastrointestinal tract after high-dose radioiodine administration in rat models. Nucl Med Commun. 2017;38:1041-1046 pubmed publisher
    The aim of this study was to evaluate the effect of lycopene against radioactive iodine (RAI)-related gastrointestinal tract acute damage in a rat model as a novel radioprotective agent.
  76. Jung K, Ahn H, Han S, Park Y, Cho B, Moon M. Association between thyroid function and lipid profiles, apolipoproteins, and high-density lipoprotein function. J Clin Lipidol. 2017;11:1347-1353 pubmed publisher
    ..in 27 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and radioactive iodine (RAI) treatment, at 3 distinct times: After surgery (baseline subclinical hyperthyroid state), on the day of undergoing ..
  77. Liu K, Yao H, Lei S, Xiong L, Qi H, Qian K, et al. The miR-124-p63 feedback loop modulates colorectal cancer growth. Oncotarget. 2017;8:29101-29115 pubmed publisher
    ..Here, we show that miR-124 can regulate two isoforms of p63, TAp63 and ΔNp63, via iASPP, while p63 modulates signal transducers and activators of transcription 1 (STAT1) expression by targeting miR-155...
  78. Hayes J, Dinkova Kostova A. Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival. Cancer Cell. 2017;32:539-541 pubmed publisher
    In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of ..
  79. Liu K, Chen W, Lei S, Xiong L, Zhao H, Liang D, et al. Wild-type and mutant p53 differentially modulate miR-124/iASPP feedback following pohotodynamic therapy in human colon cancer cell line. Cell Death Dis. 2017;8:e3096 pubmed publisher
    ..miRNA expression levels were downregulated, among which miR-124 was the most strongly downregulated, whereas iASPP expression was upregulated...
  80. Meng W, Chu R, Wang B, Wang L, Ma L, Wang L. Helicobacter pylori infection and expressions of apoptosis-related proteins p53, ASPP2 and iASPP in gastric cancer and precancerous lesions. Pathol Biol (Paris). 2013;61:199-202 pubmed publisher
    ..the relations between Helicobacter pylori infection and expressions of apoptosis-related proteins p53, ASPP and iASPP in gastric cancer and precancerous lesions. H...
  81. Pacini F. Which patient with thyroid cancer deserves systemic therapy and when?. Best Pract Res Clin Endocrinol Metab. 2017;31:291-294 pubmed publisher
    ..About 50% of these patients do respond to radioiodine (RAI) therapy, either with complete remission or stabilization of the disease on a long term period...
  82. Felicetti F, Nervo A, Piovesan A, Berardelli R, Marchisio F, Gallo M, et al. Tyrosine kinase inhibitors rechallenge in solid tumors: a review of literature and a case description with lenvatinib in thyroid cancer. Expert Rev Anticancer Ther. 2017;17:1093-1098 pubmed publisher
    ..Among them, both sorafenib and lenvatinib were approved for the treatment of radioactive iodine (RAI) refractory differentiated thyroid carcinoma (DTC)...
  83. Hirsch D, Gorshtein A, Robenshtok E, Masri Iraqi H, Akirov A, Duskin Bitan H, et al. Second Radioiodine Treatment: Limited Benefit for Differentiated Thyroid Cancer with Loforegional Persistent Disease. J Clin Endocrinol Metab. 2017;: pubmed publisher
    Radioactive iodine (RAI) treatment is often indicated after total thyroidectomy in differentiated thyroid cancer (DTC). However, its role in biochemical or loco-regional persistent DTC is unclear...
  84. Inpankaew T, Jiyipong T, Sunanta C, Kengradomkij C, Pinyopanuwat N, Jittapalapong S. Prevalence and molecular characterization of bovine Cryptosporidium from dairy cows in Northern Thailand. Acta Parasitol. 2017;62:772-774 pubmed publisher
    ..from feces of dairy cows from the northern parts of Thailand (Chiang Rai, Chiang Mai, and Lumpang provinces)...
  85. Yin J, Guo L, Wang C, Wang H, Ma Y, Liu J, et al. Effects of PPP1R13L and CD3EAP variants on lung cancer susceptibility among nonsmoking Chinese women. Gene. 2013;524:228-31 pubmed publisher
    The pathogenesis of lung cancer in the never-smokers could possibly be different from the one in smokers. PPP1R13L and CD3EAP on chromosome 19q13.3 are mainly involved in apoptosis and transcription...