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| PPM1GSummaryGene Symbol: PPM1G Description: protein phosphatase, Mg2+/Mn2+ dependent, 1G Alias: PP2CG, PP2CGAMMA, PPP2CG, PP2C, gamma, PP2C-gamma, protein phosphatase 1C, protein phosphatase 1G, protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform, protein phosphatase 2, catalytic subunit, gamma isoform, protein phosphatase 2C gamma isoform, protein phosphatase 2C isoform gamma, protein phosphatase magnesium-dependent 1 gamma Species: human Top Publications
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Publications
Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxinsJason T Maynes
Canadian Institutes of Health Research, Group in Protein Structure and Function Department of Biochemistry, Faculty of Medicine, University of Alberta, Edmonton, Alta, Canada T6G 2H7
J Mol Biol 356:111-20. 2006....
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complexWen Luo
Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112 5550, USA
EMBO J 26:1511-21. 2007..Specific inhibition of PP1 in this pathway may offer therapeutic approaches to disorders with increased beta-catenin signaling...
Loss of protein phosphatase 1c{gamma} (PPP1CC) leads to impaired spermatogenesis associated with defects in chromatin condensation and acrosome development: an ultrastructural analysisNicole Forgione
Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5
Reproduction 139:1021-9. 2010..Electron microscopy revealed major acrosomal and chromatin condensation defects in Ppp1cc mutants. Our observations are discussed in the context of known molecular changes in Ppp1cc mutant testes...- PP2C gamma: a human protein phosphatase with a unique acidic domainS M Travis
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
FEBS Lett 412:415-9. 1997..It is 34% identical to mammalian PP2C alpha and PP2C beta and we call it PP2C gamma. It more closely resembles PP2Cs from Paramecium tetraurelia and Schizosaccharomyces pombe than mammalian PP2Cs... - A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2BHiroshi Kimura
Nuclear Function and Dynamics Unit, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
J Cell Biol 175:389-400. 2006..factors that assist in the incorporation of H2A-H2B, we identified protein phosphatase (PP) 2C gamma subtype (PP2Cgamma/PPM1G) as a histone chaperone that binds to and dephosphorylates H2A-H2B... - FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progressionM A Guthridge
Department of Microbiology and Kaplan Cancer Center, New York University School of Medicine, New York 10016, USA
Mol Cell Biol 17:5485-98. 1997.... - PP2Cgamma-mediated S-phase accumulation induced by the proteasome-dependent degradation of p21(WAF1/CIP1)Eun Jung Suh
Department of Biology, Kyung Hee University, Republic of Korea
FEBS Lett 580:6100-4. 2006..However, the function of PP2Cgamma in cell cycle progression is still unclear... - The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factorM V Murray
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 USA
Genes Dev 13:87-97. 1999..A component of SCF1 is shown to be PP2Cgamma, a type 2C Ser/Thr phosphatase of previously unknown function... - Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1Eric Allemand
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Nat Struct Mol Biol 14:630-8. 2007..The human Ser/Thr phosphatase PP2Cgamma promotes spliceosome assembly... - Effects of a fluorescent Myosin light chain phosphatase inhibitor on prostate cancer cellsScott Grindrod
Drug Discovery Program, Georgetown University Medical Center Washington, DC, USA
Front Oncol 1:27. 2011..We developed a fluorescent small molecule inhibitor of MLCP using structure based design in recombinant protein phosphatase 1C. Several best fit compounds were synthesized and evaluated by their inhibition of MLCP/(32)P-MLC .. - Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargoC Manser
Department of Neuroscience P037, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, London, UK
Oncogene 31:2773-82. 2012..We show that small interfering RNA loss of LMTK2 not only reduces binding of Smad2 to KLC2, but also inhibits TGFβ-induced Smad2 signalling. Thus, LMTK2 may regulate the activity of kinesin-1 motor function and Smad2 signalling... - ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damageSvetlana V Khoronenkova
Department of Oncology, Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford OX3 7DQ, UK
Mol Cell 45:801-13. 2012..After ionizing radiation, dephosphorylation of USP7S by the ATM-dependent protein phosphatase PPM1G leads to USP7S downregulation, followed by Mdm2 downregulation and accumulation of p53... - Cdk5/p35 phosphorylates lemur tyrosine kinase-2 to regulate protein phosphatase-1C phosphorylation and activityCatherine Manser
Departments of Neuroscience and Clinical Neurosciences, Institute of Psychiatry, King s College London, London, UK
J Neurochem 121:343-8. 2012..We thus describe a new signalling pathway within the nervous system that links cdk5/p35 with PP1C and which has implications for a number of neuronal functions and neuronal dysfunction... - Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage responsePetra Beli
The NNF Center for Protein Research, University of Copenhagen, Blegdamsvej 3b, DK 2200 Copenhagen, Denmark
Mol Cell 46:212-25. 2012..We show that the splicing-regulator phosphatase PPM1G is recruited to sites of DNA damage, while the splicing-associated protein THRAP3 is excluded from these regions... - Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthaseAna Marija Hristovska
Department of Physiology and Pharmacology, University of Southern Denmark, Odense, Denmark
Hypertension 50:525-30. 2007..Inhibitors of the cAMP-protein kinase A pathway attenuated, whereas the inhibitor of protein phosphatase 1C, calyculin (10(-8) mol/L), abolished the PGE(2)-mediated relaxation... - Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complexSebastian Petri
Zentrum fur Molekulare Biologie der Universitat Heidelberg, 69120 Heidelberg, Germany
J Cell Biol 179:451-65. 2007..Here, we show that the nuclear phosphatase PPM1G/PP2Cgamma interacts with and dephosphorylates the SMN complex... - FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16Kyu Heo
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA
Mol Cell 30:86-97. 2008..Thus, these data establish FACT as the major regulator involved in H2AX exchange process that is modulated by H2AX phosphorylation and Spt16 ADP-ribosylation... - New candidate targets of protein phosphatase-1c-gamma-2 in mouse testis revealed by a differential phosphoproteome analysisH Henderson
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
Int J Androl 34:339-51. 2011..Another potential target, tubulin, was found to be misregulated during Ppp1cc(-/-) spermatogenesis, disrupting manchette development. This work represents the first survey of the testicular phosphoproteome under pathological conditions... - Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell linesScoty M Hearst
Department of Biochemistry, The University of Mississippi Medical Center, Jackson, MS 39216, USA
J Cell Sci 122:1872-81. 2009..mRNA levels of the nuclear phosphatase PPM1G are significantly reduced in primary cells and expression of PPM1G in primary cells induces CBs... - Protein phosphatase 2Cgamma regulates the level of p21Cip1/WAF1 by Akt signalingEun Jung Suh
Department of Biology, Kyung Hee University, 1 Hoegi dong Dongdaemoon ku, Seoul 130 701, Republic of Korea
Biochem Biophys Res Commun 386:467-70. 2009b>PP2Cgamma is a splicing factor that dephosphorylates specific substrates required for the formation of the spliceosome... - Basis for the isoform-specific interaction of myosin phosphatase subunits protein phosphatase 1c beta and myosin phosphatase targeting subunit 1Elizabeth Scotto-Lavino
Department of Pharmacology, Stony Brook University, Stony Brook, New York 11794 5140, USA
J Biol Chem 285:6419-24. 2010..Dephosphorylation is mediated by myosin phosphatase (MP), a complex that consists of a catalytic subunit (protein phosphatase 1c, PP1c), a large subunit (myosin phosphatase targeting subunit, MYPT), and a small subunit of unknown .. - Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attemptsDanielle M Dick
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Am J Med Genet B Neuropsychiatr Genet 153:1179-88. 2010..Further, none of the genes were located directly under the primary COGA linkage peak, which has implications for association tests following-up linkage peaks... - A testis specific isoform of endophilin B1, endophilin B1t, interacts specifically with protein phosphatase-1c gamma2 in mouse testis and is abnormally expressed in PP1c gamma null miceChristopher Hrabchak
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
Biochemistry 46:4635-44. 2007..A potential role for endophilin B1t in mammalian spermatogenesis is discussed within the context of the PP1c gamma knockout testis phenotype... - Regulation of protein phosphatase-1G from rabbit skeletal muscle. 1. Phosphorylation by cAMP-dependent protein kinase at site 2 releases catalytic subunit from the glycogen-bound holoenzymeM J Hubbard
Department of Biochemistry, University of Dundee, Scotland
Eur J Biochem 186:701-9. 1989.... - Genomic organization and functional analysis of the murine protein phosphatase 1c gamma (Ppp1cc) geneK Okano
Department of Zoology, University of Toronto, Ontario, Canada
Genomics 45:211-5. 1997..Both isoforms retain phosphatase function since they are able to complement the cold-sensitive PP1 defect caused by the dis2-11 mutation in the fission yeast Schizosaccharomyces pombe... - The NDUFS4 nuclear gene of complex I of mitochondria and the cAMP cascadeSergio Papa
Department of Medical Biochemistry and Biology, University of Bari, Piazza Giulio Cesare n 11, 70124 Bari, Italy
Biochim Biophys Acta 1555:147-53. 2002..In the mitochondrial inner membrane a PP2Cgamma-type phosphatase has also been immunodetected, which dephosphorylates the 18 kDa subunit, phosphorylated by PKA... - Different binding motifs in metabotropic glutamate receptor type 7b for filamin A, protein phosphatase 1C, protein interacting with protein kinase C (PICK) 1 and syntenin allow the formation of multimeric protein complexesRalf Enz
Emil Fischer Zentrum, Institut fur Biochemie, Friedrich Alexander Universitat Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Biochem J 372:183-91. 2003..Our results represent a molecular description of the binding mechanisms of four mGluR7-associated proteins, and indicate the formation of ternary protein complexes composed of mGluR7b, PP1C, PICK1 and syntenin... - Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequencesCristina Croci
Emil Fischer Zentrum, Institut fur Biochemie, Friedrich Alexander Universitat Erlangen Nurnberg, Fahrstr 17, Erlangen 91054, Germany
J Biol Chem 278:50682-90. 2003..Here, we identified both catalytic gamma-isoforms of protein phosphatase 1C (PP1gamma1 and PP1gamma2) as binding partners of the group I metabotropic glutamate receptors type 1a, 5a, .. - Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3Marc Flajolet
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 100:16006-11. 2003..However, phosphorylation of the mGluR3 cytoplasmic tail at Ser-845 inhibits the interaction with PP2C. These results indicate distinct functions for mGluR2 and mGluR3 and suggest a dynamic regulation of mGluR3 by PP2C... - Functional characterization of the yeast Ppz1 phosphatase inhibitory subunit Hal3: a mutagenesis studyIvan Munoz
Department de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Cerdanyola 08193, Barcelona, Spain
J Biol Chem 279:42619-27. 2004..It is unknown how Hal3 binds to Ppz1 and inhibits its activity. Although it contains a putative protein phosphatase 1c binding-like sequence (263KLHVLF268), mutagenesis analysis suggests that this motif is not required for .. - Analysis on heat stress-induced hyperphosphorylation of stathmin at serine 37 in Jurkat cells by means of two-dimensional gel electrophoresis and tandem mass spectrometryKazuyuki Nakamura
Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
J Chromatogr A 1106:181-9. 2006..The phosphorylation may cause the functional loss of stathmin for dynamic microtubule assembly and leads Jurkat cells to cell cycle arrest and apoptosis... - Different gene expression profiles of AD293 and HEK293 cell lines that show contrasting susceptibility to apoptosis induced by overexpression of Bim LJiayi Zhang
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, P R China
Acta Biochim Pol 53:525-30. 2006..transcripts of two adhesion-related genes (actin and parvin) and two apoptosis-related genes (cyclin 2 and protein phosphatase 1G) were up-regulated in AD293 cells... - Oxytocin and parturition: a role for increased myometrial calcium and calcium sensitization?Patrice Arthur
Perinatal Research Center, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada
Front Biosci 12:619-33. 2007..and the 17-kDa PKC-potentiated inhibitor of protein phosphatase 1c (CPI-17)... - Structure and regulation of the human Nek2 centrosomal kinasePeter Rellos
Structural Genomics Consortium, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, United Kingdom
J Biol Chem 282:6833-42. 2007..a role for dimerization-dependent allosteric regulation that combines with autophosphorylation and protein phosphatase 1c phosphatase activity to generate the precise spatial and temporal control required for Nek2 function in .. - Multisite phosphorylation of the glycogen-binding subunit of protein phosphatase-1G by cyclic AMP-dependent protein kinase and glycogen synthase kinase-3P Dent
Department of Biochemistry, Medical Sciences Institute, University of Dundee, Scotland
FEBS Lett 248:67-72. 1989.... - Identification of a protective role for protein phosphatase 1cgamma1 against oxidative stress-induced vascular smooth muscle cell apoptosisIgor Tchivilev
Department of Medicine, Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
J Biol Chem 283:22193-205. 2008..Together, these data indicate that PP1cgamma1 overexpression promotes VSMC survival by interfering with JNK1 and p53 phosphorylation cascades involved in apoptosis...
Research Grants
- Gene-Environment Interplay in Adolescent Alcohol UseDanielle M Dick; Fiscal Year: 2010..abstract_text> ..
- Gene-Environment Interplay in Adolescent Alcohol UseDanielle Dick; Fiscal Year: 2007..abstract_text> ..
- Gene-Environment Interplay in Adolescent Alcohol UseDanielle Dick; Fiscal Year: 2009..Understanding how environmental context moderates the risk associated with specific, measured genes will be critical for developing more informed prevention and intervention efforts in the future. ..
- Pathways to Alcohol Use Disorders in ALSPAC: A Genetic-Developmental StudyKENNETH SEEDMAN KENDLER; Fiscal Year: 2010....