PPIG

Summary

Gene Symbol: PPIG
Description: peptidylprolyl isomerase G
Alias: CARS-Cyp, CYP, SCAF10, SRCyp, peptidyl-prolyl cis-trans isomerase G, CARS-cyclophilin, CASP10, Clk-associating RS-cyclophilin, PPIase G, SR-cyclophilin, SR-cyp, SR-related CTD-associated factor 10, cyclophilin G, peptidyl-prolyl isomerase G (cyclophilin G), rotamase G
Species: human
Products:     PPIG

Top Publications

  1. Echizen H. The First-in-Class Potassium-Competitive Acid Blocker, Vonoprazan Fumarate: Pharmacokinetic and Pharmacodynamic Considerations. Clin Pharmacokinet. 2016;55:409-18 pubmed publisher
    ..7 h in healthy adults. Vonoprazan is metabolized to inactive metabolites mainly by cytochrome P450 (CYP)3A4 and to some extent by CYP2B6, CYP2C19, CYP2D6, and SULT2A1...
  2. Teschke R. Alcoholic Liver Disease: Alcohol Metabolism, Cascade of Molecular Mechanisms, Cellular Targets, and Clinical Aspects. Biomedicines. 2018;6: pubmed publisher
    ..dehydrogenase (ADH) and the microsomal ethanol-oxidizing system (MEOS), which depends on cytochrome P450 2E1 (CYP 2E1), and is inducible by chronic alcohol use...
  3. Abraham N, Sodhi K, Silvis A, Vanella L, Favero G, Rezzani R, et al. CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype. Hypertension. 2014;64:1352-61 pubmed publisher
    ..Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-derived metabolites of arachidonic acid that contribute to vascular protection by stimulating vasodilation and ..
  4. Bogacz A, Bartkowiak Wieczorek J, Mikołajczak P, Rakowska Mrozikiewicz B, Grzeskowiak E, Wolski H, et al. The influence of soybean extract on the expression level of selected drug transporters, transcription factors and cytochrome P450 genes encoding phase I drug-metabolizing enzymes. Ginekol Pol. 2014;85:348-53 pubmed
    ..Hence, the aim of our study was to assess the effects of soybean extracts on the expression level of CYP genes and their transcriptional factors...
  5. MacKenzie M, Hall R. Pharmacogenomics and pharmacogenetics for the intensive care unit: a narrative review. Can J Anaesth. 2017;64:45-64 pubmed publisher
    ..Genetic variability in response to drugs may occur as a result of alterations of drug-metabolizing (cytochrome P [CYP]) enzymes, receptors, and transport proteins leading to enhancement or delay in the therapeutic response...
  6. Hoopes S, Gruzdev A, Edin M, Graves J, Bradbury J, Flake G, et al. Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice. PLoS ONE. 2017;12:e0175348 pubmed publisher
    Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and ..
  7. Ulrich S, Ricken R, Adli M. Tranylcypromine in mind (Part I): Review of pharmacology. Eur Neuropsychopharmacol. 2017;27:697-713 pubmed publisher
    ..New studies show that, except for cytochrome P450 (CYP) 2A6, no other drug metabolizing CYP-enzymes are inhibited by TCP at therapeutic doses which defines a low ..
  8. Ghonem N, Assis D, Boyer J. Fibrates and cholestasis. Hepatology. 2015;62:635-43 pubmed publisher
    ..by regulating genes responsible for bile acid synthesis and transport in humans, including cytochrome P450 (CYP) isoform 7A1 (CYP7A1), CYP27A1, CYP8B1, uridine 5'-diphospho-glucuronosyltransferase 1A1, 1A3, 1A4, 1A6, ..
  9. Harkitis P, Daskalopoulos E, Malliou F, Lang M, Marselos M, Fotopoulos A, et al. Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver. PLoS ONE. 2015;10:e0128708 pubmed publisher
    ..glucocorticoids and prolactin (PRL) that play significant roles in the regulation of various Cytochrome P450 (CYP) enzymes...

More Information

Publications167 found, 100 shown here

  1. Li Y, Li Y, Zheng G, Zhu L, Wang J, Mu S, et al. Cytochrome P450 1A1 and 1B1 promoter CpG island methylation regulates rat liver injury induced by isoniazid. Mol Med Rep. 2017;: pubmed publisher
    ..The present study aimed to clarify the relationship between cytochrome P450 (CYP)1A1 and CYP1B1 promoter CpG island methylation and isoniazid?induced liver injury in rats, and to explore the ..
  2. Wang J, Lv Z, Lei Z, Chen Z, Lv B, Yang H, et al. Expression and functional analysis of cytochrome P450 genes in the wolf spider Pardosa pseudoannulata under cadmium stress. Ecotoxicol Environ Saf. 2019;172:19-25 pubmed publisher
    ..Increased mortality of P. pseudoannulata was observed when they were under Cd tress. In total 569 CYP genes belonging to 62 CYP subfamilies were obtained from P. pseudoannulata RNA-seq databases...
  3. Tejeda Benítez L, Olivero Verbel J. Caenorhabditis elegans, a Biological Model for Research in Toxicology. Rev Environ Contam Toxicol. 2016;237:1-35 pubmed publisher
    ..sequences from other genes related to different mechanisms of toxicity, such as heat shock, oxidative stress, CYP system, and metallothioneins among others, allowing the study of gene expression in a manner both rapid and easy...
  4. Neuman M, French S, Zakhari S, Malnick S, Seitz H, Cohen L, et al. Alcohol, microbiome, life style influence alcohol and non-alcoholic organ damage. Exp Mol Pathol. 2017;102:162-180 pubmed publisher
    ..Genetic polymorphisms of ethanol metabolizing enzymes and cytochrome p450 (CYP) 2E1 activation may change the severity of ASH and NASH...
  5. Liu Y, Yu Q, Chen Y. Effect of silibinin on CFLAR-JNK pathway in oleic acid-treated HepG2 cells. Biomed Pharmacother. 2018;108:716-723 pubmed publisher
    ..increased the intracellular levels of TG and NO; (2) up-regulated the protein expression of SREBP-1C, PNPLA3, pJNK, CYP 2E1 and CYP 4A; (3) decreased the uptake of 2-NBDG; (4) down-regulated the protein expression of CFLAR, PPARα, ..
  6. Crespo M, Sole M. The use of juvenile Solea solea as sentinel in the marine platform of the Ebre Delta: in vitro interaction of emerging contaminants with the liver detoxification system. Environ Sci Pollut Res Int. 2016;23:19229-36 pubmed publisher
    ..LDH) and citrate synthase (CS); neurotoxicity: cholinesterases (ChE); xenobiotic metabolism: cytochrome P450 (CYP)-dependent: EROD and BFCOD, carboxylesterase (CbE), glutathione S-transferase (GST) and uridine diphosphate ..
  7. Yu M, Zhang X, Guo L, Tian H, Wang W, Ru S. Anti-estrogenic effect of semicarbazide in female zebrafish (Danio rerio) and its potential mechanisms. Aquat Toxicol. 2016;170:262-270 pubmed publisher
    ..This was likely due to the SMC-mediated inhibition of cytochrome P450 (CYP) 19A mRNA levels, because this enzyme catalyzes the conversion of T to E2 in the gonads...
  8. Ohashi K, Hayashi T, Sakamoto M, Iuchi H, Suzuki H, Ebisawa T, et al. Aldosterone-producing adrenocortical carcinoma with prominent hepatic metastasis diagnosed by liver biopsy: a case report. BMC Endocr Disord. 2016;16:3 pubmed publisher
    ..aldosterone-producing ACC diagnosed by immunohistochemical staining of the metastatic tumor for Cytochrome P450 (CYP) 11β has not previously been reported and even in that case staining for adrenocortical-specific adrenal 4 ..
  9. Zhou S, Zhou Z, Yang L, Cai J. Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16:3480-675 pubmed
    Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human liver...
  10. Yin K, You Y, Swier V, Tang L, Radwan M, Pandya A, et al. Vitamin D Protects Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic Swine. Arterioscler Thromb Vasc Biol. 2015;35:2432-42 pubmed publisher
    ..Cytochrome P450 (CYP)27B1 and VD receptor were predominantly present in the CD206(+) M2 macrophage foam cell-accumulated cores in ..
  11. Sheweita S, El Hosseiny L, Nashashibi M. Protective Effects of Essential Oils as Natural Antioxidants against Hepatotoxicity Induced by Cyclophosphamide in Mice. PLoS ONE. 2016;11:e0165667 pubmed publisher
    ..In addition, treatment of mice with CP was found to induce the protein expression of CYP 3A4, 2B1/2, 2C6, 2C23...
  12. Ryu C, Choi Y, Nam H, Jeon J, Jung T, Park J, et al. Short-term regulation of the hepatic activities of cytochrome P450 and glutathione S-transferase by nose-only cigarette smoke exposure in mice. Food Chem Toxicol. 2019;125:182-189 pubmed publisher
    The present study aimed to determine the effects of cigarette smoke on the regulation of hepatic cytochrome P450 (CYP) and glutathione S-transferase (GST) enzymes in male BALB/c mice exposed to nose-only cigarette smoke for 4 days...
  13. Solhaug V, Molden E. Individual variability in clinical effect and tolerability of opioid analgesics - Importance of drug interactions and pharmacogenetics. Scand J Pain. 2017;17:193-200 pubmed publisher
    ..Cytochrome P450 (CYP)-mediated metabolism is an important process for both clinically relevant interactions and pharmacogenetic ..
  14. Savas U, Wei S, Hsu M, Falck J, Guengerich F, Capdevila J, et al. 20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR. J Biol Chem. 2016;291:16904-19 pubmed publisher
  15. Shelton R. Serotonin and Norepinephrine Reuptake Inhibitors. Handb Exp Pharmacol. 2019;: pubmed publisher
    ..Both parent compound and metabolite have low protein binding and neither inhibit CYP enzymes...
  16. Mannino G, Sesti G. Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data. Mol Diagn Ther. 2012;16:285-302 pubmed publisher
    ..genes involved in drug metabolism and transporters that influence pharmacokinetics (including the cytochrome P450 [CYP] superfamily, the organic anion transporting polypeptide [OATP] family, and the polyspecific organic cation ..
  17. Pickens C, Sordillo L, Zhang C, Fenton J. Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE). Metabolism. 2017;70:177-191 pubmed publisher
    ..Enzymatic oxygenation through the lipoxygenase (LOX) or cytochrome P450 (CYP) pathways can form oxylipids that have either proinflammatory or proresolving functions depending on the type of ..
  18. Runtz L, Girard B, Toussenot M, Espallergues J, Fayd Herbe De Maudave A, Milman A, et al. Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures. Epilepsia. 2018;59:123-134 pubmed publisher
    Available evidence points to a role of cytochrome P450 (Cyp) drug biotransformation enzymes in central nervous system diseases, including epilepsy. Deviations in drug pharmacokinetic profiles may impact therapeutic outcomes...
  19. Bustos M, Caritis S, Jablonski K, Reddy U, Sorokin Y, Manuck T, et al. The association among cytochrome P450 3A, progesterone receptor polymorphisms, plasma 17-alpha hydroxyprogesterone caproate concentrations, and spontaneous preterm birth. Am J Obstet Gynecol. 2017;217:369.e1-369.e9 pubmed publisher
    ..in the plasma concentrations of 17-alpha hydroxyprogesterone caproate by genotype were evaluated for each CYP single nucleotide polymorphism using general linear models...
  20. MUNOZ M, Martínez M, López Oliva M, Rodriguez C, Corbacho C, Carballido J, et al. Hydrogen peroxide derived from NADPH oxidase 4- and 2 contributes to the endothelium-dependent vasodilatation of intrarenal arteries. Redox Biol. 2018;19:92-104 pubmed publisher
    ..Pharmacological inhibition of Nox with apocynin and of CYP 2C epoxygenases with sulfaphenazol, but not of the NO synthase (NOS), reduced renal NADPH-stimulated O2<..
  21. Li T, Apte U. Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer. Adv Pharmacol. 2015;74:263-302 pubmed publisher
    Bile acids are synthesized from cholesterol in the liver. Some cytochrome P450 (CYP) enzymes play key roles in bile acid synthesis. Bile acids are physiological detergent molecules, so are highly cytotoxic...
  22. Muñoz M, López Oliva M, Pinilla E, Martínez M, Sánchez A, Rodríguez C, et al. CYP epoxygenase-derived H2O2 is involved in the endothelium-derived hyperpolarization (EDH) and relaxation of intrarenal arteries. Free Radic Biol Med. 2017;106:168-183 pubmed publisher
    ..that H2O2 is involved in the EDH-type relaxant responses of renal arteries and that CYP 2C epoxygenases are physiologically relevant endothelial sources of vasodilator H2O2 in the ..
  23. Veith A, Bou Aram B, Jiang W, Wang L, Zhou G, Jefcoate C, et al. Mice Lacking the Cytochrome P450 1B1 Gene Are Less Susceptible to Hyperoxic Lung Injury Than Wild Type. Toxicol Sci. 2018;165:462-474 pubmed publisher
    ..We have previously shown that cytochrome P450 (CYP)1A enzymes decrease susceptibility to hyperoxia-induced lung injury...
  24. Wang J, Zhang C, Fu L, Zhang D, Wang B, Zhang Z, et al. Protective effect of rosiglitazone against acetaminophen-induced acute liver injury is associated with down-regulation of hepatic NADPH oxidases. Toxicol Lett. 2017;265:38-46 pubmed publisher
    ..Although it did not affect hepatic cytochrome P450 (CYP)2E1 expression, RSG pretreatment attenuated reduction of hepatic glutathione peroxidase (GSH-Px), glutathione ..
  25. Khan R, Khan M, Sahreen S. CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat. BMC Complement Altern Med. 2012;12:178 pubmed publisher
    ..Moreover, increase in DNA fragmentation and oxo8dG damages while decrease in p53 and CYP 2E1 expression induced with CCl₄ was restored with the treatment of rutin...
  26. Peluso I, Palmery M, Serafini M. Association of flavonoid-rich foods and statins in the management of hypercholesterolemia: a dangerous or helpful combination?. Curr Drug Metab. 2015;16:833-46 pubmed
    ..interfere with statins' bioavailability through different mechanisms, such as competition with cytochrome P450 (CYP) enzymes, esterases, uridine diphosphate glucuronosyltransferases and transporters (P-glycoprotein, multi-drug ..
  27. Song C, Ghafoor K, Ghafoor H, Khan N, Thirunavukkarasu S, Jennings B, et al. Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice. Hypertension. 2016;67:206-13 pubmed publisher
    Cytochrome P450 (CYP) 1B1 contributes to vascular smooth muscle cell growth and hypertension in male mice...
  28. Hammoud S, Omar A, Eid A, El Mas M. CYP4A/CYP2C modulation of the interaction of calcium channel blockers with cyclosporine on EDHF-mediated renal vasodilations in rats. Toxicol Appl Pharmacol. 2017;334:110-119 pubmed publisher
    ..renal vasodilations through altering CYP4A/CYP2C signaling, and (ii) calcium channel blockers modulate the CSA/EDHF/CYP interaction. Rats were treated with CSA, verapamil, nifedipine, or their combinations for 7days...
  29. Sakul A, Ari N, Sotnikova R, Ozansoy G, Karasu C. A pyridoindole antioxidant SMe1EC2 regulates contractility, relaxation ability, cation channel activity, and protein-carbonyl modifications in the aorta of young and old rats with or without diabetes mellitus. GeroScience. 2018;40:377-392 pubmed publisher
    ..When the bath solution was shifted to cyclopiazonic acid (CYP) or CYP plus Ca2+-free medium, the contraction induced by a single dose of Phe (3 × 10-6..
  30. Neuman M, French S, French B, Seitz H, Cohen L, Mueller S, et al. Alcoholic and non-alcoholic steatohepatitis. Exp Mol Pathol. 2014;97:492-510 pubmed publisher
    ..Genetic polymorphisms of ethanol metabolizing enzymes such as cytochrome p450 (CYP) 2E1 activation may change the severity of ASH and NASH...
  31. Wei K, Zhang L. Interactions between CYP3A5*3 and POR*28 polymorphisms and lipid lowering response with atorvastatin. Clin Drug Investig. 2015;35:583-91 pubmed publisher
    ..POR) transfers electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to cytochrome P450 (CYP) 3A enzyme s, which metabolize atorvastatin...
  32. Yu R, Geary R, Flaim J, Riley G, Tribble D, vanVliet A, et al. Lack of pharmacokinetic interaction of mipomersen sodium (ISIS 301012), a 2'-O-methoxyethyl modified antisense oligonucleotide targeting apolipoprotein B-100 messenger RNA, with simvastatin and ezetimibe. Clin Pharmacokinet. 2009;48:39-50 pubmed publisher
    ..Another aim was to evaluate the ability of mipomersen sodium to inhibit major cytochrome P450 (CYP) isoenzymes in vitro...
  33. Chang M, Chen Y, Chang H, Chan C, Yeh C, Wang Y, et al. Areca nut components affect COX-2, cyclin B1/cdc25C and keratin expression, PGE2 production in keratinocyte is related to reactive oxygen species, CYP1A1, Src, EGFR and Ras signaling. PLoS ONE. 2014;9:e101959 pubmed publisher
    ..keratin 14 and cdc25C expression as well as PGE2 production were differentially regulated by α-naphthoflavone (a CYP 1A1/1A2 inhibitor), PD153035 (EGFR inhibitor), pp2 (Src inhibitor), and manumycin A (a Ras inhibitor)...
  34. Bebianno M, Gonzalez Rey M, Gomes T, Mattos J, Flores Nunes F, Bainy A. Is gene transcription in mussel gills altered after exposure to Ag nanoparticles?. Environ Sci Pollut Res Int. 2015;22:17425-33 pubmed publisher
    ..transferase (GST), caspase 3/7-1 (CAS), cathepsin L (CATH), heat-shock protein 70 (HSP 70), cytochrome P450 4YA (CYP 4YA), the elongation factor (EF1), actin and α- tubulin...
  35. He L, He T, Farrar S, Ji L, Liu T, Ma X. Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species. Cell Physiol Biochem. 2017;44:532-553 pubmed publisher
    ..Cytochrome P450 enzymes (CYP) are regarded as the markers of oxidative stress, can transform toxic metabolites into ROS, such as superoxide ..
  36. Zhang Y, Miao L, Lin L, Ren C, Liu J, Cui Y. Repeated administration of Sailuotong, a fixed combination of Panax ginseng, Ginkgo biloba, and Crocus sativus extracts for vascular dementia, alters CYP450 activities in rats. Phytomedicine. 2018;38:125-134 pubmed publisher
    ..A rapid and selective analysis method was developed to examine 5 CYP probe drugs and their specific metabolites in plasma by using online SPE followed by a single LC-MS/MS run...
  37. Sapone A, Canistro D, Vivarelli F, Paolini M. Perturbation of xenobiotic metabolism in Dreissena polymorpha model exposed in situ to surface water (Lake Trasimene) purified with various disinfectants. Chemosphere. 2016;144:548-54 pubmed publisher
    ..to DBPs, may be subject to epigenetic effects such as those referable to the up-regulation of cytochrome P450 (CYP) superfamily (ex...
  38. Iskandar A, Xiang Y, Frentzel S, Talikka M, Leroy P, Kuehn D, et al. Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts. Toxicol Sci. 2015;147:207-21 pubmed publisher
    ..Adenylate kinase (AK)-based cytotoxicity, cytochrome P450 (CYP) 1A1/1B1 activity, tissue histology, and concentrations of secreted mediators into the basolateral media, as well ..
  39. Chen L, Boinpally R, Gad N, Greenberg W, Wangsa J, Periclou A, et al. Evaluation of Cytochrome P450 (CYP) 3A4-Based Interactions of Levomilnacipran with Ketoconazole, Carbamazepine or Alprazolam in Healthy Subjects. Clin Drug Investig. 2015;35:601-12 pubmed publisher
    ..with an inhibitor (ketoconazole), an inducer (carbamazepine), or a substrate (alprazolam) of cytochrome P450 (CYP) 3A4...
  40. Guruge K, Yamanaka N, Sonobe M, Fujizono W, Yoshioka M, Akiba M, et al. Source-Related Effects of Wastewater on Transcription Factor (AhR, CAR and PXR)-Mediated Induction of Gene Expression in Cultured Rat Hepatocytes and Their Association with the Prevalence of Antimicrobial-Resistant Escherichia coli. PLoS ONE. 2015;10:e0138391 pubmed publisher
    ..hospital wastewater, exhibited significantly greater induction potency of all 6 drug metabolizing cytochrome P450 (CYP) genes examined, CYP1A1, 1A2, 1B1, 2B15, 3A1, and 3A2, whereas the wastewater at STP-1, which exclusively receives ..
  41. Ju A, Li Y, Qu Z, Li Q. Impact of the Herbal Breviscapine on the Pharmacokinetics of Simvastatin in Rats: The Involvement of CYP3A4. Drug Res (Stuttg). 2017;67:271-274 pubmed publisher
    ..breviscapine injection on the pharmacokinetics of simvastatin and the mRNA expression of hepatic cytochrome P450 (CYP) enzyme was investigated with rats...
  42. Stiborova M, Indra R, Moserova M, Bořek Dohalská L, Hodek P, Frei E, et al. Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems. Monatsh Chem. 2017;148:1959-1969 pubmed publisher
    Cytochrome P450 (CYP) 1A1 is the most important enzyme activating and detoxifying the human carcinogen benzo[a]pyrene (BaP)...
  43. Derungs A, Donzelli M, Berger B, Noppen C, Krähenbühl S, Haschke M. Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study. Clin Pharmacokinet. 2016;55:79-91 pubmed publisher
    ..Using a combination of CYP-specific probe drugs, phenotyping cocktails allow simultaneous assessment of the activity of different CYP isoforms...
  44. Farrow S, Hagel J, Beaudoin G, Burns D, Facchini P. Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy. Nat Chem Biol. 2015;11:728-32 pubmed publisher
    ..A fusion between a cytochrome P450 (CYP) and an aldo-keto reductase (AKR) catalyzes the S-to-R epimerization of reticuline via 1,2-dehydroreticuline...
  45. Gao X, Feng J, Wang W, Xiang Z, Liu X, Zhu C, et al. Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3. Nat Commun. 2015;6:7650 pubmed publisher
    ..Pirt expression is decreased in the bladder of cyclophosphamide (CYP)-treated mice, a commonly used model of bladder overactivity...
  46. Wang H, Jiang X, Wu J, Zhang L, Huang J, Zhang Y, et al. Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans. Genetics. 2016;203:241-53 pubmed publisher
    ..Mutation of cyp-23A1, encoding a homolog of human cytochrome P450 CYP7B1 that is related to neonatal hemochromatosis, further ..
  47. Negreira N, Kinyua J, De Brabanter N, Maudens K, van Nuijs A. Identification of in vitro and in vivo human metabolites of the new psychoactive substance nitracaine by liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Anal Bioanal Chem. 2016;408:5221-9 pubmed publisher
    ..nitracaine, a new psychoactive substance, using human liver microsome incubations, to evaluate the cytochrome P450 (CYP) enzyme isoforms responsible for the phase-I metabolism and to compare the information from the in vitro ..
  48. Almawash S, Mondal G, Mahato R. Coadministration of Polymeric Conjugates of Docetaxel and Cyclopamine Synergistically Inhibits Orthotopic Pancreatic Cancer Growth and Metastasis. Pharm Res. 2018;35:17 pubmed publisher
    The aim of this study was to determine whether co-administration of hedgehog (Hh) pathway inhibitor cyclopamine (CYP) and microtubule stabilizer docetaxel (DTX) as polymer-drug conjugates, methoxy poly(ethylene glycol)-block-poly(2-..
  49. Nunes M, Müller T, Murussi C, do Amaral A, Gomes J, Marins A, et al. Oxidative effects of the acute exposure to a pesticide mixture of cypermethrin and chlorpyrifos on carp and zebrafish - A comparative study. Comp Biochem Physiol C Toxicol Pharmacol. 2018;206-207:48-53 pubmed publisher
    ..Here, we investigate the potential of a commercial pesticide formulation containing (CYP) plus chlorpyrifos (CPF) to induce oxidative damage on two fish species (common carp and zebrafish)...
  50. Corrow K, Girard B, Vizzard M. Expression and response of acid-sensing ion channels in urinary bladder to cyclophosphamide-induced cystitis. Am J Physiol Renal Physiol. 2010;298:F1130-9 pubmed publisher
    ..ion channel (ASIC) isoforms, ASIC1, ASIC2a, and ASIC3, was examined in the urinary bladder after cyclophosphamide (CYP)-induced cystitis of varying duration (4 h, 48 h, and chronic)...
  51. Jan Y, Richardson J, Baker A, Mishin V, Heck D, Laskin D, et al. Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxication. Toxicol Appl Pharmacol. 2015;288:114-20 pubmed publisher
    ..Using human recombinant CYP 1A2, 2B6, 3A4 and human liver microsomes, menadione was found to inhibit the formation of paraoxon from parathion...
  52. Jing X, Peng Y, Wang X, Duan J. Effects of Ziziphus jujuba fruit extracts on cytochrome P450 (CYP1A2) activity in rats. Chin J Nat Med. 2015;13:588-94 pubmed publisher
    ..jujuba fruit (ZJ) extract on the pharmacokinetics of phenacetin, a typical substrate of a cytochrome P450 enzyme CYP 1A2, in rats. The rats were pretreated with the water extract (1.0 g · kg(-1)) or the ethanolic extract (3...
  53. Boetsch C, Parrott N, Fowler S, Poirier A, Hainzl D, Banken L, et al. Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions. Clin Pharmacokinet. 2016;55:237-47 pubmed publisher
    To assess the effect of strong and moderate cytochrome P450 (CYP) 3A4 inhibition on exposure of bitopertin, a glycine reuptake inhibitor primarily metabolized by CYP3A4, and to compare the results with predictions based on ..
  54. Graham K, Sparagano O, Finn R. Isolation of the monooxygenase complex from Rhipicephalus (Boophilus) microplus - clues to understanding acaricide resistance. Ticks Tick Borne Dis. 2016;7:614-23 pubmed publisher
    The monooxygenase complex is composed of three key proteins, a cytochrome P450 (CYP), the cytochrome P450 oxidoreductase (CPR) and cytochrome b5 and plays a key role in the metabolism and detoxification of xenobiotic substances, ..
  55. Marzolini C, Gibbons S, Khoo S, Back D. Cobicistat versus ritonavir boosting and differences in the drug-drug interaction profiles with co-medications. J Antimicrob Chemother. 2016;71:1755-8 pubmed publisher
    ..Cobicistat and ritonavir are equally strong inhibitors of cytochrome P450 (CYP) 3A4 and consequently were shown to be equivalent pharmacokinetic enhancers for elvitegravir and for the PIs ..
  56. Mandal A, Raju S, Viswanathan C. Long-term culture and cryopreservation does not affect the stability and functionality of human embryonic stem cell-derived hepatocyte-like cells. In Vitro Cell Dev Biol Anim. 2016;52:243-51 pubmed publisher
    ..The hESC-derived HLCs have shown the capability to display sensitivity and an alteration in the level of CYP enzyme upon drug induction...
  57. Srinivas N. Clinical drug-drug interactions of bosentan, a potent endothelial receptor antagonist, with various drugs: Physiological role of enzymes and transporters. Gen Physiol Biophys. 2016;35:243-58 pubmed publisher
    ..Bosentan is mainly metabolized by cytochrome P450 (CYP) 3A4 and 2C9 enzymes with the involvement of multiple transporters that control its hepatic uptake and biliary ..
  58. Argikar U, Potter P, Hutzler J, Marathe P. Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance. AAPS J. 2016;18:1391-1405 pubmed
    ..As such, these low microsomal turnover compounds are often substrates for non-CYP-mediated metabolism. UGTs, esterases, and aldehyde oxidase are major enzymes involved in catalyzing such metabolism...
  59. Yavropoulou M, Panagiotou G, Topouridou K, Karayannopoulou G, Koletsa T, Zarampoukas T, et al. Vitamin D receptor and progesterone receptor protein and gene expression in papillary thyroid carcinomas: associations with histological features. J Endocrinol Invest. 2017;40:1327-1335 pubmed publisher
    ..Expression of CYP 24A1, but not CYP27B1, was increased in approximately all PTC specimens and was associated with lymph node ..
  60. Cao L, Kwara A, Greenblatt D. Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017;69:1762-1772 pubmed publisher
    ..Generation of this metabolite is mediated by Cytochrome-P450 (CYP) isoforms, mainly CYP2E1...
  61. Cleary Y, Gertz M, Morcos P, Yu L, Youdim K, Phipps A, et al. Model-Based Assessments of CYP-Mediated Drug-Drug Interaction Risk of Alectinib: Physiologically Based Pharmacokinetic Modeling Supported Clinical Development. Clin Pharmacol Ther. 2017;: pubmed publisher
    ..and its major active metabolite M4 exhibited drug-drug interaction (DDI) potential through cytochrome P450 (CYP) enzymes CYP3A4 and CYP2C8 in vitro...
  62. Ochiai W, Kobayashi H, Kitaoka S, Kashiwada M, Koyama Y, Nakaishi S, et al. Effect of the active ingredient of Kaempferia parviflora, 5,7-dimethoxyflavone, on the pharmacokinetics of midazolam. J Nat Med. 2018;72:607-614 pubmed publisher
    ..hand, in vitro studies have reported that it directly inhibits the drug metabolizing enzyme family cytochrome P450 (CYP) 3As...
  63. Schmid Y, Vizeli P, Hysek C, Prestin K, Meyer zu Schwabedissen H, Liechti M. CYP2D6 function moderates the pharmacokinetics and pharmacodynamics of 3,4-methylene-dioxymethamphetamine in a controlled study in healthy individuals. Pharmacogenet Genomics. 2016;26:397-401 pubmed publisher
    The role of genetic polymorphisms in cytochrome (CYP) 2D6 involved in the metabolism of 3,4-methylene-dioxymethamphetamine (MDMA, ecstasy) is unclear...
  64. Armani S, Ting L, Sauter N, Darstein C, Tripathi A, Wang L, et al. Drug Interaction Potential of Osilodrostat (LCI699) Based on Its Effect on the Pharmacokinetics of Probe Drugs of Cytochrome P450 Enzymes in Healthy Adults. Clin Drug Investig. 2017;37:465-472 pubmed publisher
    ..evaluated the inhibitory effect of osilodrostat on the pharmacokinetics of probe substrates of the cytochrome P450 (CYP) enzymes CYP1A2, CYP2C19, CYP2D6, and CYP3A4...
  65. Rajman I, Knapp L, Morgan T, Masimirembwa C. African Genetic Diversity: Implications for Cytochrome P450-mediated Drug Metabolism and Drug Development. EBioMedicine. 2017;17:67-74 pubmed publisher
    ..We reviewed publications (1995-April 2016) reporting frequencies of known cytochrome P450 (CYP) variants in African populations...
  66. Şengül E, Gelen V, Gedikli S, Özkanlar S, Gür C, Çelebi F, et al. The protective effect of quercetin on cyclophosphamide-Induced lung toxicity in rats. Biomed Pharmacother. 2017;92:303-307 pubmed publisher
    Cyclophosphamide (CYP) is an anticancer agent widely used in chemotherapy. It has been suggested that CYP causes toxicity in many organs, including the lungs and testes...
  67. Soda M, Fujitani M, Michiuchi R, Shibayama A, Kanamori K, Yoshikuni S, et al. Association Between Tacrolimus Pharmacokinetics and Cytochrome P450 3A5 and Multidrug Resistance Protein 1 Exon 21 Polymorphisms. Transplant Proc. 2017;49:1492-1498 pubmed publisher
    ..immunosuppressive drug, are reportedly associated with single-nucleotide polymorphisms (SNPs) of cytochrome P450 (CYP) 3A5 and multidrug resistance protein 1 (MDR1)...
  68. Sergent T, Dupont I, Jassogne C, Ribonnet L, Van der Heiden E, Scippo M, et al. CYP1A1 induction and CYP3A4 inhibition by the fungicide imazalil in the human intestinal Caco-2 cells-comparison with other conazole pesticides. Toxicol Lett. 2009;184:159-68 pubmed publisher
    ..e. ketoconazole, propiconazole and tebuconazole, were also studied. IMA induced cytochrome P450 (CYP) 1A1 activity to the same extent as benzo(a)pyrene (B(a)P) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), in a dose-..
  69. Minjie S, Defei H, Zhimin H, Weiding W, Yuhua Z. Targeting pancreatic cancer cells by a novel hydroxamate-based histone deacetylase (HDAC) inhibitor ST-3595. Tumour Biol. 2015;36:9015-22 pubmed publisher
    ..Inhibition of MPTP, by cyclosporin A, sanglifehrin A, or by cyclophilin-D (Cyp-D) siRNA knockdown, dramatically inhibited ST-3595-induced pancreatic cancer cell apoptosis...
  70. Wei Y, Wang D, Yang H, Cao H. Cytochrome P450 CYP 2C19*2 Associated with Adverse 1-Year Cardiovascular Events in Patients with Acute Coronary Syndrome. PLoS ONE. 2015;10:e0132561 pubmed publisher
    ..We investigated the correlation of CYP 2C19 681G > A mutation with clopidogrel resistance (CR)...
  71. Tang X, Chen S. Epigenetic Regulation of Cytochrome P450 Enzymes and Clinical Implication. Curr Drug Metab. 2015;16:86-96 pubmed
    ..The high inter-subject variability of CYP bioactivity has been largely attributed to gene polymorphism until the rapid development in epigenetics in the last ..
  72. Rysz M, Bromek E, Haduch A, Liskova B, Wojcikowski J, Daniel W. The reverse role of the hypothalamic paraventricular (PVN) and arcuate (ARC) nuclei in the central serotonergic regulation of the liver cytochrome P450 isoform CYP2C11. Biochem Pharmacol. 2016;112:82-9 pubmed publisher
    ..PVN) or arcuate nuclei (ARC) of the hypothalamus on the neuroendocrine regulation of cytochrome P450 (CYP)...
  73. Manning J, Carter T, Latif A, Horsley A, Cooper J, Armstrong M, et al. 'Our Care through Our Eyes'. Impact of a co-produced digital educational programme on nurses' knowledge, confidence and attitudes in providing care for children and young people who have self-harmed: a mixed-methods study in the UK. BMJ Open. 2017;7:e014750 pubmed publisher
    ..confidence and behavioural intention of registered children's nurses working with children and young people (CYP) admitted with self-harm.(2) To explore the perceived impact, suitability and usefulness of the intervention...
  74. Yang Y, Ye X, He B, Liu J. Cadmium potentiates toxicity of cypermethrin in zebrafish. Environ Toxicol Chem. 2016;35:435-45 pubmed publisher
    ..Cypermethrin-mediated induction of transcription levels and catalytic activities of cytochrome P450 (CYP) enzyme were significantly down-regulated by Cd in both zebrafish larvae and adults...
  75. den Braver Sewradj S, den Braver M, Vermeulen N, Commandeur J, Richert L, Vos J. Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer. Toxicol In Vitro. 2016;33:71-9 pubmed publisher
    ..We investigated phase I (CYP) and phase II (UGT and SULT) metabolism of three drugs related to drug-induced liver injury (DILI), namely ..
  76. Thomford N, Dzobo K, Chopera D, Wonkam A, Maroyi A, Blackhurst D, et al. In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions. Molecules. 2016;21: pubmed publisher
    ..The herbal extracts were risk ranked for HDI based on the IC50 values determined for each CYP enzyme. Newbouldia laevis inhibited CYP1A2, CYP2C9, and CYP2C19 enzyme activities with Ki of 2.84 µg/mL, 1...
  77. Wang S, Xing P, Zhang C, Deng B. Association of CYP2J2 gene polymorphisms with ischemic stroke and stroke subtypes in Chinese population. Medicine (Baltimore). 2017;96:e6266 pubmed publisher
    ..in China and is a multifactorial disease influenced by many factors including genetic factors like the allele for CYP 2J2. It has been demonstrated that CYP2J2 polymorphisms alter the transcriptional activity...
  78. Ji M, Zhang Y, Li N, Wang C, Xia R, Zhang Z, et al. Nicotine Component of Cigarette Smoke Extract (CSE) Decreases the Cytotoxicity of CSE in BEAS-2B Cells Stably Expressing Human Cytochrome P450 2A13. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..49% vs. 7.06%), which was flatted by 8-methoxypsoralen (8-MOP), a CYP inhibitor. CSE-O rather than CSE or CSE-N increased apoptosis of B-2A13 cells rather than B-V cells...
  79. Ma F, Zhang Z, Jiang J, Hu J. Chromium (VI) potentiates the DNA adducts (O(6)-methylguanine) formation of N-nitrosodimethylamine in rat: implication on carcinogenic risk. Chemosphere. 2015;139:256-9 pubmed publisher
    ..Although Cr(VI) did not alter the CYP 2E1 enzyme activity, it decreased GSH content, which would be an potential mechanism for the potentiated O(6)-MeG ..
  80. Basińska Ziobroń A, Daniel W, Wójcikowski J. Inhibition of human cytochrome P450 isoenzymes by a phenothiazine neuroleptic levomepromazine: An in vitro study. Pharmacol Rep. 2015;67:1178-82 pubmed publisher
    Inhibition of cytochrome P450 (CYP) isoenzymes is the most common cause of harmful drug-drug interactions...
  81. Ladda M, Goralski K. The Effects of CKD on Cytochrome P450-Mediated Drug Metabolism. Adv Chronic Kidney Dis. 2016;23:67-75 pubmed publisher
    ..recognized that CKD also impacts nonrenal clearance mechanisms such as hepatic and intestinal cytochrome P450 (CYP) enzymes and drug transport proteins, the latter of which is beyond the scope of this review...
  82. Madeen E, Löhr C, You H, Siddens L, Krueger S, Dashwood R, et al. Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. Mol Carcinog. 2017;56:163-171 pubmed publisher
    The cytochrome P450 (CYP) 1 family is active toward numerous environmental pollutants, including polycyclic aromatic hydrocarbons (PAHs)...
  83. Yang H, Ni H, Guo F, Ding Y, Shi Y, Lahiri P, et al. Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice. J Biol Chem. 2016;291:18663-74 pubmed publisher
    Xenobiotics exposure increases endoplasmic reticulum (ER) proliferation and cytochrome P-450 (CYP) induction to sustain metabolic requirements...
  84. Liu W, Wang T, Wang B, Liu X, He X, Liu Y, et al. CYP2C8-derived epoxyeicosatrienoic acids decrease oxidative stress-induced endothelial apoptosis in development of atherosclerosis: Role of Nrf2 activation. J Huazhong Univ Sci Technolog Med Sci. 2015;35:640-645 pubmed publisher
    The aim of the present study is to investigate how cytochrome P450 enzymes (CYP) 2C8-derived epoxyeicosatrienoic acids (EETs) regulate the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and protect against oxidative ..
  85. Kanbur M, Siliğ Y, Eraslan G, Karabacak M, Soyer Sarıca Z, Şahin S. The toxic effect of cypermethrin, amitraz and combinations of cypermethrin-amitraz in rats. Environ Sci Pollut Res Int. 2016;23:5232-42 pubmed publisher
    In this study, the effects of cypermethrin (CYP), amitraz (AMT) and combined cypermethrin-amitraz (CYP-AMT) on some serum biochemical, oxidative stress and drug-metabolising parameters were investigated in male Wistar albino rats...
  86. Jannot A, Vuillemin X, Etienne I, Buchler M, Hurault de Ligny B, Choukroun G, et al. A Lack of Significant Effect of POR*28 Allelic Variant on Tacrolimus Exposure in Kidney Transplant Recipients. Ther Drug Monit. 2016;38:223-9 pubmed publisher
    ..P450 oxidoreductase (POR), which might be associated with an increased metabolic activity of P450 cytochromes (CYP) 3A5 and 3A4...
  87. Saito J, Okamura A, Takeuchi K, Hanioka K, Okada A, Ohata T. High content analysis assay for prediction of human hepatotoxicity in HepaRG and HepG2 cells. Toxicol In Vitro. 2016;33:63-70 pubmed publisher
    ..content analysis (HCA) assay in human hepatocyte cell lines such as the HepaRG with normal expression levels of CYP enzymes and HepG2 with extremely low expression levels of CYP enzymes...
  88. Tabur S, Oztuzcu S, Oguz E, Demiryürek S, Dağlı H, Alasehirli B, et al. CYP gene expressions in obesity-associated metabolic syndrome. Obes Res Clin Pract. 2016;10:719-723 pubmed publisher
    The contribution of cytochrome P450 (CYP) gene expressions in metabolic syndrome (MetS) has not been elucidated, and was the aim of this study...
  89. Wang D, Li Y, Cui P, Zhao Q, Tan B, Zhang Z, et al. Zerumbone induces gastric cancer cells apoptosis: Involving cyclophilin A. Biomed Pharmacother. 2016;83:740-745 pubmed publisher
    ..The treatment with zerumbone downregulated Cyp A and Bcl-2 levels, upregulated Bax levels, and caused Cytochrome c (Cyt-C) to release, activating Caspase-3...
  90. Cojutti P, Candoni A, Forghieri F, Isola M, Zannier M, Bigliardi S, et al. Variability of Voriconazole Trough Levels in Haematological Patients: Influence of Comedications with cytochrome P450(CYP) Inhibitors and/or with CYP Inhibitors plus CYP Inducers. Basic Clin Pharmacol Toxicol. 2016;118:474-9 pubmed publisher
    ..The purpose of this study was to identify the magnitude of influence of comedications with CYP inhibitors and/or with CYP inhibitors plus CYP inducers on voriconazole trough level (Cmin )...
  91. Mulligan K, Wedderburn L, Newman S. The experience of taking methotrexate for juvenile idiopathic arthritis: results of a cross-sectional survey with children and young people. Pediatr Rheumatol Online J. 2015;13:58 pubmed publisher
    Children and young people (CYP) with juvenile idiopathic arthritis (JIA) are known to have impaired health-related quality of life (HRQoL), which is improved significantly for many by treatment with methotrexate (MTX)...
  92. Dutour R, Poirier D. Inhibitors of cytochrome P450 (CYP) 1B1. Eur J Med Chem. 2017;135:296-306 pubmed publisher
    ..This review put emphasis on different families of inhibitors, especially those reported since 2003. ..