Gene Symbol: PPIF
Description: peptidylprolyl isomerase F
Alias: CYP3, CyP-M, Cyp-D, CypD, peptidyl-prolyl cis-trans isomerase F, mitochondrial, PPIase F, cyclophilin 3, cyclophilin D, cyclophilin F, mitochondrial cyclophilin, peptidyl-prolyl cis-trans isomerase, mitochondrial, rotamase F
Species: human
Products:     PPIF

Top Publications

  1. Davidov T, Nagar M, Kierson M, Chekmareva M, Chen C, Lu S, et al. Carbonic anhydrase 4 and crystallin α-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. J Surg Res. 2014;190:565-74 pubmed publisher
    ..growth factor 13 (FGF13), carbonic anhydrase 4 (CA4), crystallin alpha-B (CRYAB), peptidylprolyl isomerase F (PPIF), asparagine synthase (ASNS), sodium channel, non-voltage gated, 1 alpha subunit (SCNN1A), frizzled homolog 1 (FZD1)..
  2. Jiang D, Wang Y, Li M, Ma Y, Wang Y. SIRT3 in Neural Stem Cells Attenuates Microglia Activation-Induced Oxidative Stress Injury Through Mitochondrial Pathway. Front Cell Neurosci. 2017;11:7 pubmed publisher
    ..of SIRT3 attenuated activated microglia-induced NSC dysfunction included the decreased mPTP opening and cyclophilin D (CypD) protein expression, inhibition of mitochondrial cytochrome C (Cyt C) release to cytoplasm, declined Bax/..
  3. Song T, Yang M, Chen J, Huang L, Yin H, He T, et al. Prognosis of sepsis induced by cecal ligation and puncture in mice improved by anti-Clonorchis Sinensis cyclopholin a antibodies. Parasit Vectors. 2015;8:502 pubmed publisher
    ..Furthermore, the survival rate was elevated, ranging from 10.0 % to 45.0 % compared to the control group. These antibodies may have a favorable effect on sepsis via inhibition of enzymic activity or protection of endothelial cells. ..
  4. He Y, Leung K, Ren Y, Pei J, Ge J, Tombran Tink J. PEDF improves mitochondrial function in RPE cells during oxidative stress. Invest Ophthalmol Vis Sci. 2014;55:6742-55 pubmed publisher
    ..In addition, PEDF blocked effects of oxidative stress on expression of cyclophilin D and UCP2, genes controlling mitochondrial function, and the apoptotic genes caspase 3, Bax, and Bcl2...
  5. Perrone A, Milduberger N, Fuchs A, Bustos P, Bua J. A Functional Analysis of the Cyclophilin Repertoire in the Protozoan Parasite Trypanosoma Cruzi. Biomolecules. 2018;8: pubmed publisher
    ..i>TcCyP22, an orthologue of mitochondrial CyPD, is involved in the regulation of parasite cell death. Our findings on T...
  6. Raish M, Ahmad A, Ansari M, Alkharfy K, Ahad A, Al jenoobi F, et al. Effects of sinapic acid on hepatic cytochrome P450 3A2, 2C11, and intestinal P-glycoprotein on the pharmacokinetics of oral carbamazepine in rats: Potential food/herb-drug interaction. Epilepsy Res. 2019;153:14-18 pubmed publisher
    ..and MRT and the reduction in Kel and CL/F values resulted from the significant inhibition of CYP3 A2, the CYP2C11-mediated metabolism of CBZ in the liver, and the inhibition of intestinal P-glycoprotein/MDR1, ..
  7. Schama R, Pedrini N, Juárez M, Nelson D, Torres A, Valle D, et al. Rhodnius prolixus supergene families of enzymes potentially associated with insecticide resistance. Insect Biochem Mol Biol. 2016;69:91-104 pubmed publisher
    ..In R. prolixus 88 CYP genes were found, with representatives in the four clans (CYP2, CYP3, CYP4 and mitochondrial) usually found in insects. R...
  8. Lee D, Jung Y. Protective Effect of Right Ventricular Mitochondrial Damage by Cyclosporine A in Monocrotaline-induced Pulmonary Hypertension. Korean Circ J. 2018;48:1135-1144 pubmed publisher
    ..were no significant differences in voltage-dependent anion channel, adenine nucleotide translocator 1 and cyclophilin D expression in western blot and RT-PCR between the 3 groups. CsA reduces MCT induced RV mitochondrial damage...
  9. Ishikita A, Matoba T, Ikeda G, Koga J, Mao Y, Nakano K, et al. Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocar. J Am Heart Assoc. 2016;5: pubmed publisher
    ..MOMP inhibition was also observed in cyclophilin D knockout (CypD-KO) mice, which lack the mitochondrial permeability transition pore (MPTP) opening...

More Information

Publications138 found, 100 shown here

  1. Hanes S. Prolyl isomerases in gene transcription. Biochim Biophys Acta. 2015;1850:2017-34 pubmed publisher
    ..This article is part of a Special Issue entitled Proline-directed Foldases: Cell Signaling Catalysts and Drug Targets. ..
  2. Honarpisheh M, Desai J, Marschner J, Weidenbusch M, Lech M, Vielhauer V, et al. Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis. Biosci Rep. 2016;36: pubmed publisher
    ..death domain (FADD), cellular inhibitor of apoptosis protein (CIAP)1, CIAP2, glutathione peroxidase-4 (GPX4), cyclophilin D (CYPD), CASP1, NLRP3 and poly(ADP-ribose) polymerase-1 (PARP1) in human and mouse solid organs...
  3. Wu C, Wu Y, Liu C, Wang Y, Na W, Wang N, et al. Comparative proteome analysis of abdominal adipose tissues between fat and lean broilers. Proteome Sci. 2016;14:9 pubmed publisher
    ..Our results have provided further information for understanding the basic genetics control of growth and development of broiler adipose tissue. ..
  4. Nevers Q, Ruiz I, Ahnou N, Donati F, Brillet R, Softic L, et al. Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the Potential for Broad Anti-Flaviviridae Activity. Antimicrob Agents Chemother. 2018;62: pubmed publisher
  5. Zhang H, Wang J, Li S, Wang S, Liu M, Wang W, et al. Molecular cloning, expression, purification and functional characterization of an antifungal cyclophilin protein from Panax ginseng. Biomed Rep. 2017;7:527-531 pubmed publisher
    ..In addition, pgCyP showed high PPIase activity. To the best of our knowledge, the present study is the first successful effort to clone and characterize a CyP-like protein gene from Panax ginseng...
  6. Youcef G, Belaidi E, Waeckel L, Fazal L, Clemessy M, Vincent M, et al. Tissue kallikrein is required for the cardioprotective effect of cyclosporin A in myocardial ischemia in the mouse. Biochem Pharmacol. 2015;94:22-9 pubmed publisher
    ..CsA interacts with Cyclophilin D (CypD) preventing opening of the mitochondrial permeability transition pore (mPTP)...
  7. Garvin A, Aurigemma N, Hackenberger J, Korzick D. Age and ischemia differentially impact mitochondrial ultrastructure and function in a novel model of age-associated estrogen deficiency in the female rat heart. Pflugers Arch. 2017;469:1591-1602 pubmed publisher
    ..05). Elevated cyclophilin D and exacerbated I/R-induced mitochondrial acetylation in MO OVX suggest permeability transition pore ..
  8. Wang D, Jones A, Wang W, Wang M, Korthuis R. Soluble guanylate cyclase activation during ischemic injury in mice protects against postischemic inflammation at the mitochondrial level. Am J Physiol Gastrointest Liver Physiol. 2016;310:G747-56 pubmed publisher
    ..Other investigators have associated phosphorylation of the GSK-3? substrate cyclophilin D (pCyPD) with mPTP formation...
  9. Zhao K, Li J, He W, Song D, Zhang X, Zhang D, et al. Cyclophilin B facilitates the replication of Orf virus. Virol J. 2017;14:114 pubmed publisher
    ..Cellular CypB was confirmed to be significantly up-regulated in the ORFV-infected MDBK cells at an early phase of infection, which could effectively facilitate the replication of ORFV. ..
  10. Huang Z, Pandya D, Banta D, Ansari M, Oh U. Cyclophilin inhibitor NIM811 ameliorates experimental allergic encephalomyelitis. J Neuroimmunol. 2017;311:40-48 pubmed publisher
    ..Anti-inflammatory and neuroprotective mechanisms may be targeted by inhibition of cyclophilin A-dependent and cyclophilin D-dependent functions, respectively...
  11. Rasch J, Ünal C, Klages A, Karsli Ü, Heinsohn N, Brouwer R, et al. Peptidyl-Prolyl-cis/trans-Isomerases Mip and PpiB of Legionella pneumophila Contribute to Surface Translocation, Growth at Suboptimal Temperature, and Infection. Infect Immun. 2019;87: pubmed publisher
    ..Accordingly, we propose that Mip and PpiB are virulence modulators of L. pneumophila with compensatory action and pleiotropic effects. ..
  12. Ghartey Kwansah G, Li Z, Feng R, Wang L, Zhou X, Chen F, et al. Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster. BMC Dev Biol. 2018;18:7 pubmed publisher
    ..Specific therapeutics targeting cellular signaling pathways will also be discussed. ..
  13. Chen Q, Chen Q, Sun G, Zheng K, Yao Z, Han Y, et al. Genome-Wide Identification of Cyclophilin Gene Family in Cotton and Expression Analysis of the Fibre Development in Gossypium barbadense. Int J Mol Sci. 2019;20: pubmed publisher
    ..This study provides a valuable resource for further investigations of CYP gene functions and molecular mechanisms in cotton. ..
  14. Liu C, Wang B, Zhou B, Jian X, Zhang X, Wang Y. The responses of Oncorhynchus mykiss coping with BDE-47 stress via PXR-mediated detoxification and Nrf2-mediated antioxidation system. Aquat Toxicol. 2019;207:63-71 pubmed publisher
    ..We studied the detoxification system genes pregnane X receptor (PXR) and downstream genes (cytochrome 3 A, CYP3 A; glutathione S-transferase, GST) and their corresponding enzyme activity and found that the above indicators in ..
  15. Parone P, Da Cruz S, Han J, McAlonis Downes M, Vetto A, Lee S, et al. Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis. J Neurosci. 2013;33:4657-71 pubmed publisher
    ..of mitochondrial Ca(2+)-buffering capacity to disease mechanism(s) by eliminating ubiquitous expression of cyclophilin D, a critical regulator of Ca(2+)-mediated opening of the mitochondrial permeability transition pore that ..
  16. Lee C, Chavez J, Garcia Menendez L, Choi Y, Roe N, Chiao Y, et al. Normalization of NAD+ Redox Balance as a Therapy for Heart Failure. Circulation. 2016;134:883-94 pubmed publisher
    ..conferring protein at lysine-70 in adenosine triphosphate synthase complex promoted its interaction with cyclophilin D, and sensitized the opening of mitochondrial permeability transition pore...
  17. Oh Y, Jeong K, Kim K, Lee Y, Jeong S, Kim S, et al. Cyclophilin B protects SH-SY5Y human neuroblastoma cells against MPP(+)-induced neurotoxicity via JNK pathway. Biochem Biophys Res Commun. 2016;478:1396-402 pubmed publisher
    ..The data suggest that overexpressed CypB protects neuronal cells from MPP+-induced dopaminergic neuronal cell death. ..
  18. Sulaiman M, Chu Z, Blanco V, Vallabhapurapu S, Franco R, Qi X. SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas. Mol Cancer. 2015;14:78 pubmed publisher
    ..Apoptosis induction was not critically dependent on reactive oxygen species (ROS) production and Cyclophilin D, since pretreatment with N-acetyl cysteine and cyclosporine A, respectively, did not prevent Smac or Cyto c ..
  19. Luo J, Yang X, Qiu S, Li X, Xiang E, Fang Y, et al. Sex difference in monocrotaline-induced developmental toxicity and fetal hepatotoxicity in rats. Toxicology. 2019;418:32-40 pubmed publisher
    ..efficiency of MCT in fetal liver microsomes, serum MCT, pyrrole-protein adduction derived from MCT, and hepatic CYP3 A expression of fetuses in vivo...
  20. Kaur G, Singh S, Singh H, Chawla M, Dutta T, Kaur H, et al. Characterization of Peptidyl-Prolyl Cis-Trans Isomerase- and Calmodulin-Binding Activity of a Cytosolic Arabidopsis thaliana Cyclophilin AtCyp19-3. PLoS ONE. 2015;10:e0136692 pubmed publisher
    ..However, the PPIase activity of the Arabidopsis cyclophilin was not affected by CaM. The implications of these findings are discussed in the context of Ca(2+) signaling and cyclophilin activity in Arabidopsis. ..
  21. Ye F, Li X, Li F, Li J, Chang W, Yuan J, et al. Cyclosporin A protects against Lead neurotoxicity through inhibiting mitochondrial permeability transition pore opening in nerve cells. Neurotoxicology. 2016;57:203-213 pubmed publisher
    ..this study was designed to investigate the role of mitochondrial permeability transition (MPT) and cyclophilin D (CyPD), a component of MPT pore (MPTP), in Pb-induced mitochondrial apoptosis in nerve cells...
  22. Wei M, Yamada T, Yamano S, Kato M, Kakehashi A, Fujioka M, et al. Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats. Toxicol Appl Pharmacol. 2013;273:1-9 pubmed publisher
    ..CYP) enzymes in the liver revealed that DPAA induced the expression of CYP1B1, but not any other CYP1, CYP2, or CYP3 enzymes, suggesting that CYP1B1 might be the enzyme responsible for the metabolic activation of DPAA...
  23. Harikishore A, Yoon H. Immunophilins: Structures, Mechanisms and Ligands. Curr Mol Pharmacol. 2015;9:37-47 pubmed
    ..vivax, recent progress on immunophilin inhibitor development, and future perspectives of structure-based design of non-immunosuppressive immunophilin ligands with potential pharmacological activities against infectious diseases. ..
  24. Xiao Y, Karam C, Yi J, Zhang L, Li X, Yoon D, et al. ROS-related mitochondrial dysfunction in skeletal muscle of an ALS mouse model during the disease progression. Pharmacol Res. 2018;138:25-36 pubmed publisher
    ..analysis of subcellular mitochondrial fractionation of G93A muscle revealed an increased expression level of cyclophilin D (CypD), a regulatory component of the mitochondrial permeability transition pore (mPTP), at the age of 4 ..
  25. Talari N, Panigrahi M, Madigubba S, Phanithi P. Overexpression of aryl hydrocarbon receptor (AHR) signalling pathway in human meningioma. J Neurooncol. 2018;137:241-248 pubmed publisher
    ..Since AHR signalling pathway was known to involve in inhibition of apoptosis in cancer cells, we evaluated the cyclophilin D levels which maintains mitochondrial permeability transition pore a critical event during apoptosis...
  26. Shao Q, Fallica J, Casin K, Murphy E, Steenbergen C, Kohr M. Characterization of the sex-dependent myocardial S-nitrosothiol proteome. Am J Physiol Heart Circ Physiol. 2016;310:H505-15 pubmed publisher
    ..Unique S-nitrosylated proteins in the female group included the F1FO-ATPase and cyclophilin D. We also utilized label-free peptide analysis to quantify levels of common S-nitrosylated identifications and ..
  27. Stifani S. The Multiple Roles of Peptidyl Prolyl Isomerases in Brain Cancer. Biomolecules. 2018;8: pubmed publisher
    ..This review will discuss studies providing evidence for multiple roles of PIN1 and other PPIases in glioblastoma and medulloblastoma, the most frequent adult and pediatric primary brain tumors. ..
  28. Wang W, Yang Y, Xiong Z, Kong J, Fu X, Shen F, et al. Inhibition of glycogen synthase kinase 3beta ameliorates triptolide-induced acute cardiac injury by desensitizing mitochondrial permeability transition. Toxicol Appl Pharmacol. 2016;313:195-203 pubmed publisher
    ..Mechanistically, GSK-3? interacted with and phosphorylated cyclophilin F (Cyp-F), a key regulator of mitochondrial permeability transition pore (mPTP)...
  29. Ahmed Belkacem A, Colliandre L, Ahnou N, Nevers Q, Gelin M, Bessin Y, et al. Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nat Commun. 2016;7:12777 pubmed publisher
    ..This family of compounds has the potential for broad-spectrum, high-barrier-to-resistance treatment of viral infections. ..
  30. de Wilde A, Pham U, Posthuma C, Snijder E. Cyclophilins and cyclophilin inhibitors in nidovirus replication. Virology. 2018;522:46-55 pubmed publisher
    ..Also the involvement of the FK-506-binding proteins and parvulins is discussed. The nidovirus data are placed in a broader perspective by summarizing the most relevant data on Cyp interactions and Cyp inhibitors for other RNA viruses. ..
  31. Theurey P, Tubbs E, Vial G, Jacquemetton J, Bendridi N, Chauvin M, et al. Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver. J Mol Cell Biol. 2016;8:129-43 pubmed publisher
    ..This glucose-sensing system is deficient in the liver of insulin-resistant ob/ob and cyclophilin D-KO mice, both characterized by chronic disruption of MAM integrity, mitochondrial fission, and altered ..
  32. Han J, Kim D, Kim H, Nelson D, Lee J. Genome-wide identification of 52 cytochrome P450 (CYP) genes in the copepod Tigriopus japonicus and their B[?]P-induced expression patterns. Comp Biochem Physiol Part D Genomics Proteomics. 2017;23:49-57 pubmed publisher
    ..japonicus CYP genes were assigned to five distinct clans: CYP2 (22 genes), CYP3 (19 genes), CYP4 (two genes), CYP20 (one gene), and mitochondrial (eight genes)...
  33. Taddeo E, Laker R, Breen D, Akhtar Y, Kenwood B, Liao J, et al. Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Mol Metab. 2014;3:124-34 pubmed publisher
    ..a link between mitochondrial dysfunction and insulin resistance by inhibiting the mPTP gatekeeper protein cyclophilin D (CypD) in vivo and in vitro...
  34. Chen S, Lv X, Hu B, Zhao L, Li S, Li Z, et al. Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis. Apoptosis. 2018;23:299-313 pubmed publisher
    ..CsA down-regulated mitochondrial cyclophilin D expression, but had little effects on RIPK1 expression and pRIPK1 activation...
  35. Kaku Y, Tsuchiya A, Kanno T, Nakano T, Nishizaki T. Diarachidonoylphosphoethanolamine induces necrosis/necroptosis of malignant pleural mesothelioma cells. Cell Signal. 2015;27:1713-9 pubmed publisher
    ..DAPE-induced mitochondrial damage was attenuated by cyclosporin A, an inhibitor of cyclophilin D (CypD). DAPE did not affect expression and mitochondrial localization of p53 protein in NCI-H28 cells...
  36. Fakharnia F, Khodagholi F, Dargahi L, Ahmadiani A. Prevention of Cyclophilin D-Mediated mPTP Opening Using Cyclosporine-A Alleviates the Elevation of Necroptosis, Autophagy and Apoptosis-Related Markers Following Global Cerebral Ischemia-Reperfusion. J Mol Neurosci. 2017;61:52-60 pubmed publisher
    ..Here, we aimed to evaluate the role of the cyclophilin D (CypD) as a prominent mediator of mPTP, on necroptosis and autophagy as well as apoptosis, beyond the global ..
  37. Li P, Liu Y, Burns N, Zhao K, Song R. SIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells. Int J Mol Med. 2017;39:1127-1136 pubmed publisher
    ..Knockdown of SIRT3 abrogated SIRT1-mediated deacetylation of cyclophilin D (CyPD)...
  38. Hou W, Leong K, Ozols E, Tesch G, Nikolic Paterson D, Ma F. Cyclophilin D promotes tubular cell damage and the development of interstitial fibrosis in the obstructed kidney. Clin Exp Pharmacol Physiol. 2017;: pubmed publisher
    b>Cyclophilin D (CypD) is an important component in mitochondrial-dependent tubular cell death in acute kidney injury. However, it is not known whether CypD contributes to tubular cell damage in chronic interstitial fibrosis...
  39. Seifert E, Ligeti E, Mayr J, Sondheimer N, Hajnóczky G. The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease. Biochem Biophys Res Commun. 2015;464:369-75 pubmed publisher
    ..Furthermore, PiC has also been described to affect cell survival mechanisms via interactions with cyclophilin D and the viral mitochondrial-localized inhibitor of apoptosis (vMIA)...
  40. Milerová M, Drahota Z, Chytilová A, Tauchmannová K, Houštěk J, Ošťádal B. Sex difference in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load. Mol Cell Biochem. 2016;412:147-54 pubmed publisher
    ..and related to the degree of cardiac tolerance to I/R injury and (ii) whether changes in MPTP components-cyclophilin D (CypD) and ATP synthase-can be involved in this process...
  41. Naveen V, Chu C, Chen B, Tsai Y, Hsiao C, Sun Y. Helicobacter pylori cell binding factor 2: Insights into domain motion. J Struct Biol. 2016;194:90-101 pubmed publisher
    ..The domain motion in HpCBF2 might be necessary for the isomerization activity of PPIase and the accommodation of the unfolded and partially folded peptides to refold by chaperone domain. ..
  42. Folda A, Citta A, Scalcon V, Calì T, Zonta F, Scutari G, et al. Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State. Sci Rep. 2016;6:23071 pubmed publisher
    ..Here we have investigated the redox correlation between this system and the mitochondrial enzyme cyclophilin D. The peptidyl prolyl cis-trans isomerase activity of cyclophilin D was stimulated by the thioredoxin system, ..
  43. Koch A, Biedenkopf D, Furch A, Weber L, Rossbach O, Abdellatef E, et al. An RNAi-Based Control of Fusarium graminearum Infections Through Spraying of Long dsRNAs Involves a Plant Passage and Is Controlled by the Fungal Silencing Machinery. PLoS Pathog. 2016;12:e1005901 pubmed publisher
    ..graminearum pathosystem, we alternatively demonstrate that a spray application of a long noncoding dsRNA (791 nt CYP3-dsRNA), which targets the three fungal cytochrome P450 lanosterol C-14α-demethylases, required for biosynthesis of ..
  44. Klawitter J, Seres T, Pennington A, Beatty J, Klawitter J, Christians U. Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart. J Cell Biochem. 2017;118:2933-2940 pubmed publisher
    b>Cyclophilin D (CypD) is a mitochondrial chaperone that regulates the mitochondrial permeability transition pore...
  45. Panel M, Ghaleh B, Morin D. Ca2+ ionophores are not suitable for inducing mPTP opening in murine isolated adult cardiac myocytes. Sci Rep. 2017;7:4283 pubmed publisher
    ..We monitored mPTP opening using the calcein/cobalt fluorescence technique in adult rat and wild type or cyclophilin D (CypD) knock-out mice cardiomyocytes...
  46. Eichner T, Kutter S, Labeikovsky W, Buosi V, Kern D. Molecular Mechanism of Pin1-Tau Recognition and Catalysis. J Mol Biol. 2016;428:1760-75 pubmed publisher
    ..Together, our data reemphasize the complicated scenario between binding and catalysis of multiple phosphorylated tau by Pin1 and the need for directly linking biological phenotypes and residue-specific turnover in Pin1 substrates. ..
  47. Ying Y, Padanilam B. Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?. Cell Mol Life Sci. 2016;73:2309-24 pubmed publisher
    ..b>Cyclophilin D, along with adenine nucleotide translocator and the phosphate carrier are considered to be important ..
  48. Casado Vela J, Matthiesen R, Sellés S, Naranjo J. Protein-Protein Interactions: Gene Acronym Redundancies and Current Limitations Precluding Automated Data Integration. Proteomes. 2013;1:3-24 pubmed publisher
    ..Finally, this strategy was applied to compile bona fide information on human DREAM protein interactome, which constitutes liable training datasets that can be used to improve computational predictions. ..
  49. Toselli F, Dodd P, Gillam E. Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs. Drug Metab Rev. 2016;48:379-404 pubmed publisher
    ..the evidence behind the functional importance of P450s from the "xenobiotic-metabolizing" families, CYP1, CYP2 and CYP3 in the brain...
  50. Du H, Shidu Yan S. Unlocking the Door to Neuronal Woes in Alzheimer's Disease: A? and Mitochondrial Permeability Transition Pore. Pharmaceuticals (Basel). 2010;3:1936-1948 pubmed
    ..b>Cyclophilin D (Cyp D) plays a central role in opening mitochondrial permeability transition pores, ultimately leading to ..
  51. Sharma V, Salwan R, Sharma P, Kanwar S. Elucidation of biocontrol mechanisms of Trichoderma harzianum against different plant fungal pathogens: Universal yet host specific response. Int J Biol Macromol. 2017;95:72-79 pubmed publisher
    ..In a broader term, the transcripts were upregulated at various time intervals but the optimum expression of cyp3, abc, nrp, tga1, pmk, ech42 and glh20 varied with respect to host fungi...
  52. Mohd Siddique M, McCann G, Sonawane V, Horley N, Gatchie L, Joshi P, et al. Quinazoline derivatives as selective CYP1B1 inhibitors. Eur J Med Chem. 2017;130:320-327 pubmed publisher
    ..Further selectivity studies with homologous CYPs, belonging to the CYP1, CYP2 and CYP3 family of enzymes, showed that the compounds are likely to be free from critical drug-drug interaction liability...
  53. Zhang L, He D, Li K, Liu H, Wang B, Zheng L, et al. Emodin targets mitochondrial cyclophilin D to induce apoptosis in HepG2 cells. Biomed Pharmacother. 2017;90:222-228 pubmed publisher
    ..Specifically, A mitochondrial matrix protein (cyclophilin D, CyPD) is involved in emodin-induced apoptosis, and the inhibitor of CyPD (cyclosporin A) could almost ..
  54. Alvariño R, Alonso E, Tribalat M, Gegunde S, Thomas O, Botana L. Evaluation of the Protective Effects of Sarains on H2O2-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Neuroblastoma Cells. Neurotox Res. 2017;32:368-380 pubmed publisher
    ..1 and 1 ?M blocked the mitochondrial permeability transition pore (mPTP) opening through cyclophilin D inhibition...
  55. Li P, Meng X, Bian H, Burns N, Zhao K, Song R. Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage. Oncotarget. 2015;6:36998-7011 pubmed publisher
    ..Acetylation of cyclophilin D (CyPD), a component of mPT pore, was increased...
  56. Xu T, Xie J, Yang S, Ye S, Luo M, Wu X. First characterization of three cyclophilin family proteins in the oyster, Crassostrea ariakensis Gould. Fish Shellfish Immunol. 2016;55:257-66 pubmed publisher
    ..RLO incubation upregulated the mRNA expression levels of Ca-CyPs, indicating that three Ca-CyPs might be involved in oyster immune response against RLO infection. ..
  57. Geiser E, Przybilla S, Engel M, Kleineberg W, Büttner L, Sarikaya E, et al. Genetic and biochemical insights into the itaconate pathway of Ustilago maydis enable enhanced production. Metab Eng. 2016;38:427-435 pubmed publisher
    ..This conversion is catalyzed by the P450 monooxygenase Cyp3, encoded by cyp3, a gene, which is adjacent to the itaconate gene cluster of U. maydis...
  58. Burstein S, Kim H, Fels J, Qian L, Zhang S, Zhou P, et al. Estrogen receptor beta modulates permeability transition in brain mitochondria. Biochim Biophys Acta Bioenerg. 2018;1859:423-433 pubmed publisher
    ..calcium threshold for MPT than male mitochondria, and that this sex difference depends on the MPT regulator cyclophilin D (CypD)...
  59. Rieusset J, Fauconnier J, Paillard M, Belaidi E, Tubbs E, Chauvin M, et al. Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance. Diabetologia. 2016;59:614-23 pubmed publisher
    ..We recently identified cyclophilin D (CYPD) as a new partner of this complex and demonstrated a new role for MAMs in the control of insulin's ..
  60. Thomloudi E, Skagia A, Venieraki A, Katinakis P, Dimou M. Functional analysis of the two cyclophilin isoforms of Sinorhizobium meliloti. World J Microbiol Biotechnol. 2017;33:28 pubmed publisher
    ..coli BL21 in the presence of abiotic stress conditions such as increased heat and salt concentration. Our results support and strengthen previous high-throughput studies implicating S. meliloti cyclophilins in various stress conditions. ..
  61. Rangu M, Ye Z, Bhatti S, Zhou S, Yang Y, Fish T, et al. Association of Proteomics Changes with Al-Sensitive Root Zones in Switchgrass. Proteomes. 2018;6: pubmed publisher
    ..Data are available via ProteomeXchange with identifiers PXD008882 and PXD009125. ..
  62. Elkamhawy A, Park J, Hassan A, Ra H, Pae A, Lee J, et al. Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction. Eur J Med Chem. 2017;128:56-69 pubmed publisher
    ..Using CDocker algorithm, a molecular docking model presented a plausible binding mode for 5x with cyclophilin D (CypD) receptor as a major component of mPTP...
  63. Zhu H, Sun A. Programmed necrosis in heart disease: Molecular mechanisms and clinical implications. J Mol Cell Cardiol. 2018;116:125-134 pubmed publisher
    ..While MPT-dependent necrosis is another modality of necrosis characterized by MPT pore opening and cyclophilin-D (CypD)-dependent death signaling...
  64. Huang K, Horng J. Modulating the Affinities of Phosphopeptides for the Human Pin1 WW Domain Using 4-Substituted Proline Derivatives. Biochemistry. 2015;54:6186-94 pubmed publisher
    ..The results of this study provide new valuable information for designing and developing effective inhibitors of human Pin1. ..
  65. Zhou C, Chen Z, Lu X, Wu H, Yang Q, Xu D. Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells. Tumour Biol. 2016;37:3135-44 pubmed publisher
    ..membrane potential (MMP) decrease and mitochondrial adenine nucleotide translocator-1 (ANT-1)-cyclophilin-D (CyPD) association...
  66. Han H, Choi B, Surh Y. Dual Roles of Pin1 in Cancer Development and Progression. Curr Pharm Des. 2017;23:4422-4425 pubmed publisher
    ..However, a role for Pin1 as a putative tumor suppressor has recently been suggested. Systematic dissection of pro-oncogenic vs. tumor suppressive functions of Pin1 will be necessary...
  67. Mantel C, O Leary H, Chitteti B, Huang X, Cooper S, Hangoc G, et al. Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock. Cell. 2015;161:1553-65 pubmed publisher
    ..We linked ROS production and induction of the mitochondrial permeability transition pore (MPTP) via cyclophilin D and p53 as mechanisms of EPHOSS...
  68. Ikolo F, Zhang M, Harrington D, Robinson C, Waller A, Sutcliffe I, et al. Characterisation of SEQ0694 (PrsA/PrtM) of Streptococcus equi as a functional peptidyl-prolyl isomerase affecting multiple secreted protein substrates. Mol Biosyst. 2015;11:3279-86 pubmed publisher
    ..These data add to our knowledge of the mechanisms by which lipoprotein PPIases contribute to the virulence of streptococcal pathogens. ..
  69. Lu X, Kwong J, Molkentin J, Bers D. Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings. Circ Res. 2016;118:834-41 pubmed publisher
    ..suppressed by preventing mitochondrial Ca(2+) influx, by mPTP inhibitor cyclosporine A, sanglifehrin, and in cyclophilin D knockout mice. These tPTP events were 57±5 s in duration, but were rare (occurring in <0...
  70. Chen M, Jiang Q, Liu Y, Zhang Y, He B, Wei M, et al. C6 ceramide dramatically increases vincristine sensitivity both in vivo and in vitro, involving AMP-activated protein kinase-p53 signaling. Carcinogenesis. 2015;36:1061-70 pubmed publisher
    ..Together, C6 sensitizes vincristine-induced anticancer activity in vivo and in vitro, involving activating AMPK-p53 signaling. ..
  71. Lin D, Lechleiter J. Mitochondrial targeted cyclophilin D protects cells from cell death by peptidyl prolyl isomerization. J Biol Chem. 2002;277:31134-41 pubmed
    b>Cyclophilin D (CyPD) is thought to sensitize opening of the mitochondrial permeability transition pore (mPTP) based on the findings that cyclosporin A (CsA), a pseudo-CyPD substrate, hyperpolarizes the mitochondrial membrane potential (..
  72. Ojima Kato T, Yamamoto N, Nagai S, Shima K, Akiyama Y, Ota J, et al. Application of proteotyping Strain Solution™ ver. 2 software and theoretically calculated mass database in MALDI-TOF MS typing of Salmonella serotype. Appl Microbiol Biotechnol. 2017;101:8557-8569 pubmed publisher
    ..We conclude that Strain Solution ver. 2 software integrated with the accurate mass database will be useful for the bacterial proteotyping by MALDI-TOF MS-based microbial classification in the clinical and food safety fields. ..
  73. Rogals M, Greenwood A, Kwon J, Lu K, Nicholson L. Neighboring phosphoSer-Pro motifs in the undefined domain of IRAK1 impart bivalent advantage for Pin1 binding. FEBS J. 2016;283:4528-4548 pubmed publisher
  74. Dongsheng Z, Zhiguang F, Junfeng J, Zifan L, Li W. Cyclophilin A Aggravates Collagen-Induced Arthritis via Promoting Classically Activated Macrophages. Inflammation. 2017;40:1761-1772 pubmed publisher
    ..Our findings provide evidence that PPIase CypA promoted macrophages polarization toward pro-inflammatory M1 phenotype via transcriptional activating NF-?B, thus leading to aggravated arthritis. ..
  75. Springer J, Visavadiya N, Sullivan P, Hall E. Post-Injury Treatment with NIM811 Promotes Recovery of Function in Adult Female Rats after Spinal Cord Contusion: A Dose-Response Study. J Neurotrauma. 2017;: pubmed publisher
    ..Cyclosporine A (CsA) is thought to inhibit mPT by binding to cyclophilin D and has been shown to be effective in models of CNS injury...
  76. Kim S, Jeong H, Hong S, Lee M, Cho S, Cha H. Quercetin induced ROS production triggers mitochondrial cell death of human embryonic stem cells. Oncotarget. 2017;8:64964-64973 pubmed publisher
    ..Of interest, peptidylprolyl isomerase D [PPID, also called cyclophilin D (CypD)], which functions in mitochondrial permeability transition and mitochondrial cell death, was highly ..
  77. Park H, Cho H, Kim T. Physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. Metab Brain Dis. 2018;33:283-292 pubmed publisher
    ..The results suggest that physiological stimulations such as exercise improve hippocampal function and suppress apoptosis, potentially preventing the memory loss associated with obesity-induced insulin resistance. ..
  78. He Y, Ge J, Tombran Tink J. Mitochondrial defects and dysfunction in calcium regulation in glaucomatous trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2008;49:4912-22 pubmed publisher
    ..The expression of cyclophilin D, a protein that induces MPTP opening was also measured...
  79. Fu M, Shi W, Li Z, Liu H. Activation of mPTP-dependent mitochondrial apoptosis pathway by a novel pan HDAC inhibitor resminostat in hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2016;477:527-533 pubmed publisher
    ..The results of this preclinical study indicate that resminostat (or plus sorafenib) could be further investigated as a valuable anti-HCC strategy. ..
  80. Xu Y, Ma H, Fang Y, Zhang Z, Shao J, Hong M, et al. Cisplatin-induced necroptosis in TNF? dependent and independent pathways. Cell Signal. 2017;31:112-123 pubmed publisher
    ..Deficiency of cyclophilin-D (CypD) partially reduced cisplatin-induced cell death, indicating CypD mediated-mPTP opening plays an important role ..
  81. Klawitter J, Pennington A, Klawitter J, Thurman J, Christians U. Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney. Sci Rep. 2017;7:10540 pubmed publisher
    The mitochondrial matrix protein cyclophilin D (CypD) is an essential component of the mitochondrial permeability transition pore (MPTP). Here we characterized the effects of CypD ablation on bioenergetics in the kidney...
  82. Galat A. Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities. Biomolecules. 2017;7: pubmed publisher
    ..These three attributes enhance binding of PPIase/pharmacophore complexes to diverse intracellular entities, some of which perturb signalization pathways causing immunosuppression and other system-altering phenomena in humans. ..
  83. Csizmok V, Montecchio M, Lin H, Tyers M, Sunnerhagen M, Forman Kay J. Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCFFbw7 Ubiquitin Ligase. Structure. 2018;26:28-39.e2 pubmed publisher
    ..Our findings support the general principle that multiple weak binding motifs within disordered regions can synergize to yield high-affinity interactions and provide rapidly evolvable means to build and fine-tune regulatory events. ..
  84. Zhao X, Khan N, Gan H, Tzelepis F, Nishimura T, Park S, et al. Bcl-xL mediates RIPK3-dependent necrosis in M. tuberculosis-infected macrophages. Mucosal Immunol. 2017;10:1553-1568 pubmed publisher
    ..Furthermore, necrosis is associated with stabilization of hexokinase II on the mitochondria as well as cyclophilin D-dependent mitochondrial permeability transition...
  85. Park I, Londhe A, Lim J, Park B, Jung S, Lee J, et al. Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in A?-induced mitochondrial dysfunction. J Comput Aided Mol Des. 2017;31:929-941 pubmed publisher
    b>Cyclophilin D (CypD) is a mitochondria-specific cyclophilin that is known to play a pivotal role in the formation of the mitochondrial permeability transition pore (mPTP)...
  86. Hseu Y, Thiyagarajan V, Ou T, Yang H. CoQ0-induced mitochondrial PTP opening triggers apoptosis via ROS-mediated VDAC1 upregulation in HL-60 leukemia cells and suppresses tumor growth in athymic nude mice/xenografted nude mice. Arch Toxicol. 2018;92:301-322 pubmed publisher
    ..The activation of p-GSK3β expression, cyclophilin D inhibition, and p53 activation through ROS are involved in CoQ0-induced HL-60 apoptotic cell death...
  87. Kumar R, Moche M, Winblad B, Pavlov P. Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51. Sci Rep. 2017;7:14288 pubmed publisher
    ..In a nutshell, our findings provide new opportunity to engage this important protein-protein interaction target by small molecules designed by structure based drug design strategy. ..
  88. Crompton M, Virji S, Ward J. Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore. Eur J Biochem. 1998;258:729-35 pubmed
  89. McStay G, Clarke S, Halestrap A. Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore. Biochem J. 2002;367:541-8 pubmed
    ..The two effects together greatly sensitize the MPTP to [Ca(2+)]. ..
  90. Chatzianastasiou A, Bibli S, Andreadou I, Efentakis P, Kaludercic N, Wood M, et al. Cardioprotection by H2S Donors: Nitric Oxide-Dependent and ?Independent Mechanisms. J Pharmacol Exp Ther. 2016;358:431-40 pubmed publisher
    ..Both Na2S and AP39 reduced infarct size in mice lacking cyclophilin-D (CypD), a modulator of the mitochondrial permeability transition pore (PTP)...
  91. Zulian A, Schiavone M, Giorgio V, Bernardi P. Forty years later: Mitochondria as therapeutic targets in muscle diseases. Pharmacol Res. 2016;113:563-573 pubmed publisher
    ..fulfilled, and the potential of mitochondria as pharmacological targets in muscle diseases may soon become a reality, particularly through inhibition of the mitochondrial permeability transition pore and its regulator cyclophilin D.
  92. Sun F, Si Y, Bao H, Xu Y, Pan X, Zeng L, et al. Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice. Cell Mol Neurobiol. 2017;37:1457-1464 pubmed publisher
    ..cognitive dysfunction in the hippocampus induced by sepsis-associated encephalopathy (SAE) via acetylation of cyclophilin D (CypD) and opening of mitochondrial permeability transition pore...