Gene Symbol: PPID
Description: peptidylprolyl isomerase D
Alias: CYP-40, CYPD, peptidyl-prolyl cis-trans isomerase D, 40 kDa peptidyl-prolyl cis-trans isomerase D, PPIase D, cyclophilin 40, cyclophilin D, cyclophilin-related protein, rotamase D, testicular tissue protein Li 147
Species: human
Products:     PPID

Top Publications

  1. Nair S, Toran E, Rimerman R, Hjermstad S, Smithgall T, Smith D. A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. Cell Stress Chaperones. 1996;1:237-50 pubmed
  2. Park M, Chu F, Xie J, Wang Y, Bhattacharya P, Chan W. Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40. Anal Biochem. 2011;410:257-65 pubmed publisher
    ..Collectively, we conclude that reduction of the HIF-1 ? protein by RACK1 is CyP40-mediated. ..
  3. Carrello A, Allan R, Morgan S, Owen B, Mok D, Ward B, et al. Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. Cell Stress Chaperones. 2004;9:167-81 pubmed
    ..exists as a multicomponent complex that includes heat shock protein (Hsp)90; one of the immunophilins cyclophilin 40 (CyP40), FKBP51, or FKBP52; and an additional p23 protein component...
  4. Gaither L, Borawski J, Anderson L, Balabanis K, Devay P, Joberty G, et al. Multiple cyclophilins involved in different cellular pathways mediate HCV replication. Virology. 2010;397:43-55 pubmed publisher
    ..Together, the experiments provide strong evidence that NIM811 reduces viral replication by inhibition of multiple cyclophilins and pathways with protein trafficking as the most strongly and persistently affected pathway. ..
  5. Periyasamy S, Hinds T, Shemshedini L, Shou W, Sanchez E. FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A. Oncogene. 2010;29:1691-701 pubmed publisher
    ..These proteins and their cognate ligands thus provide new strategies in the treatment of PCa. ..
  6. Schülke J, Wochnik G, Lang Rollin I, Gassen N, Knapp R, Berning B, et al. Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors. PLoS ONE. 2010;5:e11717 pubmed publisher
    ..The differential effects of the TPR proteins on steroid receptors bear on all physiological processes related to steroid hormone activity. ..
  7. Phillips S, Chokshi S, Chatterji U, Riva A, Bobardt M, Williams R, et al. Alisporivir inhibition of hepatocyte cyclophilins reduces HBV replication and hepatitis B surface antigen production. Gastroenterology. 2015;148:403-14.e7 pubmed publisher
    ..in drug response was evaluated by small interfering RNA knockdown of cyclophilin (CYP)A, CYPC, or CYPD in HepG2215 cells, or CYPA knockdown in HuH-7 cells...
  8. Harikishore A, Yoon H. Immunophilins: Structures, Mechanisms and Ligands. Curr Mol Pharmacol. 2015;9:37-47 pubmed
    ..vivax, recent progress on immunophilin inhibitor development, and future perspectives of structure-based design of non-immunosuppressive immunophilin ligands with potential pharmacological activities against infectious diseases. ..
  9. Perrone A, Milduberger N, Fuchs A, Bustos P, Bua J. A Functional Analysis of the Cyclophilin Repertoire in the Protozoan Parasite Trypanosoma Cruzi. Biomolecules. 2018;8: pubmed publisher
    ..i>TcCyP22, an orthologue of mitochondrial CyPD, is involved in the regulation of parasite cell death. Our findings on T...

More Information

Publications128 found, 100 shown here

  1. Hanes S. Prolyl isomerases in gene transcription. Biochim Biophys Acta. 2015;1850:2017-34 pubmed publisher
    ..This article is part of a Special Issue entitled Proline-directed Foldases: Cell Signaling Catalysts and Drug Targets. ..
  2. Zhang H, Wang J, Li S, Wang S, Liu M, Wang W, et al. Molecular cloning, expression, purification and functional characterization of an antifungal cyclophilin protein from Panax ginseng. Biomed Rep. 2017;7:527-531 pubmed publisher
    ..In addition, pgCyP showed high PPIase activity. To the best of our knowledge, the present study is the first successful effort to clone and characterize a CyP-like protein gene from Panax ginseng...
  3. Nevers Q, Ruiz I, Ahnou N, Donati F, Brillet R, Softic L, et al. Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the Potential for Broad Anti-Flaviviridae Activity. Antimicrob Agents Chemother. 2018;62: pubmed publisher
  4. Tanaka Y, Amano A, Morisaki M, Sato Y, Sasaki T. Cellular peptidyl-prolyl cis/trans isomerase Pin1 facilitates replication of feline coronavirus. Antiviral Res. 2016;126:1-7 pubmed publisher
    ..Dipentamethylene thiuram monosulfide, a specific inhibitor of Pin1, inhibited FCoV replication. These data indicate that Pin1 modulates FCoV propagation. ..
  5. Huang Z, Pandya D, Banta D, Ansari M, Oh U. Cyclophilin inhibitor NIM811 ameliorates experimental allergic encephalomyelitis. J Neuroimmunol. 2017;311:40-48 pubmed publisher
    ..Anti-inflammatory and neuroprotective mechanisms may be targeted by inhibition of cyclophilin A-dependent and cyclophilin D-dependent functions, respectively...
  6. Chen Q, Chen Q, Sun G, Zheng K, Yao Z, Han Y, et al. Genome-Wide Identification of Cyclophilin Gene Family in Cotton and Expression Analysis of the Fibre Development in Gossypium barbadense. Int J Mol Sci. 2019;20: pubmed publisher
    ..This study provides a valuable resource for further investigations of CYP gene functions and molecular mechanisms in cotton. ..
  7. Kaur G, Singh S, Singh H, Chawla M, Dutta T, Kaur H, et al. Characterization of Peptidyl-Prolyl Cis-Trans Isomerase- and Calmodulin-Binding Activity of a Cytosolic Arabidopsis thaliana Cyclophilin AtCyp19-3. PLoS ONE. 2015;10:e0136692 pubmed publisher
    ..However, the PPIase activity of the Arabidopsis cyclophilin was not affected by CaM. The implications of these findings are discussed in the context of Ca(2+) signaling and cyclophilin activity in Arabidopsis. ..
  8. Galat A. Compression of Large Sets of Sequence Data Reveals Fine Diversification of Functional Profiles in Multigene Families of Proteins: A Study for Peptidyl-Prolyl cis/trans Isomerases (PPIase). Biomolecules. 2019;9: pubmed publisher
    ..This type of dimer may have some crucial function in the regulation of some nuclear complexes at different stages of the cell cycle. ..
  9. Stifani S. The Multiple Roles of Peptidyl Prolyl Isomerases in Brain Cancer. Biomolecules. 2018;8: pubmed publisher
    ..This review will discuss studies providing evidence for multiple roles of PIN1 and other PPIases in glioblastoma and medulloblastoma, the most frequent adult and pediatric primary brain tumors. ..
  10. Lawen A. Biosynthesis of cyclosporins and other natural peptidyl prolyl cis/trans isomerase inhibitors. Biochim Biophys Acta. 2015;1850:2111-20 pubmed publisher
    ..This article is part of a Special Issue entitled Proline-directed Foldases: Cell signaling catalysts and drug targets. ..
  11. Ahmed Belkacem A, Colliandre L, Ahnou N, Nevers Q, Gelin M, Bessin Y, et al. Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nat Commun. 2016;7:12777 pubmed publisher
    ..This family of compounds has the potential for broad-spectrum, high-barrier-to-resistance treatment of viral infections. ..
  12. de Wilde A, Pham U, Posthuma C, Snijder E. Cyclophilins and cyclophilin inhibitors in nidovirus replication. Virology. 2018;522:46-55 pubmed publisher
    ..Also the involvement of the FK-506-binding proteins and parvulins is discussed. The nidovirus data are placed in a broader perspective by summarizing the most relevant data on Cyp interactions and Cyp inhibitors for other RNA viruses. ..
  13. Zhou Y, Keyhani N, Zhang Y, Luo Z, Fan Y, Li Y, et al. Dissection of the contributions of cyclophilin genes to development and virulence in a fungal insect pathogen. Environ Microbiol. 2016;18:3812-3826 pubmed publisher
    ..These results revealed common and unique roles for cyclophilins in B. bassiana and validate a method for examining the effects of multi-gene families via simultaneous gene knockdown. ..
  14. Schumann M, Ihling C, Prell E, Schierhorn A, Sinz A, Fischer G, et al. Identification of low abundance cyclophilins in human plasma. Proteomics. 2016;16:2815-2826 pubmed publisher
    ..Using this approach, eight different Cyp (CypA, CypB, CypC, Cyp40 (PPID), CypE, CypD (PPIF), CypH, and CypL1) were unambiguously detected in healthy human blood plasma...
  15. Xu T, Xie J, Yang S, Ye S, Luo M, Wu X. First characterization of three cyclophilin family proteins in the oyster, Crassostrea ariakensis Gould. Fish Shellfish Immunol. 2016;55:257-66 pubmed publisher
    ..RLO incubation upregulated the mRNA expression levels of Ca-CyPs, indicating that three Ca-CyPs might be involved in oyster immune response against RLO infection. ..
  16. Thomloudi E, Skagia A, Venieraki A, Katinakis P, Dimou M. Functional analysis of the two cyclophilin isoforms of Sinorhizobium meliloti. World J Microbiol Biotechnol. 2017;33:28 pubmed publisher
    ..coli BL21 in the presence of abiotic stress conditions such as increased heat and salt concentration. Our results support and strengthen previous high-throughput studies implicating S. meliloti cyclophilins in various stress conditions. ..
  17. Nath P, Isakov N. Insights into peptidyl-prolyl cis-trans isomerase structure and function in immunocytes. Immunol Lett. 2015;163:120-31 pubmed publisher
    ..PPIases may therefore serve as useful diagnostic tools and potential therapeutic targets. ..
  18. Galat A. Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities. Biomolecules. 2017;7: pubmed publisher
    ..These three attributes enhance binding of PPIase/pharmacophore complexes to diverse intracellular entities, some of which perturb signalization pathways causing immunosuppression and other system-altering phenomena in humans. ..
  19. Jiang D, Wang Y, Li M, Ma Y, Wang Y. SIRT3 in Neural Stem Cells Attenuates Microglia Activation-Induced Oxidative Stress Injury Through Mitochondrial Pathway. Front Cell Neurosci. 2017;11:7 pubmed publisher
    ..of SIRT3 attenuated activated microglia-induced NSC dysfunction included the decreased mPTP opening and cyclophilin D (CypD) protein expression, inhibition of mitochondrial cytochrome C (Cyt C) release to cytoplasm, declined Bax/..
  20. Miller M, Moore G, Bertin F, Kritchevsky J. What's New in Old Horses? Postmortem Diagnoses in Mature and Aged Equids. Vet Pathol. 2016;53:390-8 pubmed publisher
    ..years of age (n = 125), and (3) to catalog coexisting lesions in equids with pituitary pars intermedia dysfunction (PPID). Breed and sex were evenly distributed between the age groups...
  21. Kallscheuer N, Bott M, van Ooyen J, Polen T. Single-Domain Peptidyl-Prolyl cis/trans Isomerase FkpA from Corynebacterium glutamicum Improves the Biomass Yield at Increased Growth Temperatures. Appl Environ Microbiol. 2015;81:7839-50 pubmed publisher
    ..Comparative transcriptome analysis revealed 69 genes which exhibit ≥2-fold mRNA level changes in C. glutamicum ΔfkpA, giving insight into the transcriptional response upon mild heat stress when FkpA is absent. ..
  22. Ghartey Kwansah G, Li Z, Feng R, Wang L, Zhou X, Chen F, et al. Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster. BMC Dev Biol. 2018;18:7 pubmed publisher
    ..3) FKBP51 and FKBP52 (dFKBP59), along with Cyclophilin 40 and protein phosphatase 5, function as Hsp90 immunophilin co-chaperones within steroid receptor-Hsp90 ..
  23. Song T, Yang M, Chen J, Huang L, Yin H, He T, et al. Prognosis of sepsis induced by cecal ligation and puncture in mice improved by anti-Clonorchis Sinensis cyclopholin a antibodies. Parasit Vectors. 2015;8:502 pubmed publisher
    ..Furthermore, the survival rate was elevated, ranging from 10.0 % to 45.0 % compared to the control group. These antibodies may have a favorable effect on sepsis via inhibition of enzymic activity or protection of endothelial cells. ..
  24. Dutta T, Kaur H, Singh S, Mishra A, Tripathi J, Singh N, et al. Developmental changes in storage proteins and peptidyl prolyl cis-trans isomerase activity in grains of different wheat cultivars. Food Chem. 2011;128:450-7 pubmed publisher
    ..Principal component analysis revealed the association of PPIase activity with either gliadin or total proteins, suggesting their significant role in the deposition of storage proteins in wheat. ..
  25. He Y, Leung K, Ren Y, Pei J, Ge J, Tombran Tink J. PEDF improves mitochondrial function in RPE cells during oxidative stress. Invest Ophthalmol Vis Sci. 2014;55:6742-55 pubmed publisher
    ..In addition, PEDF blocked effects of oxidative stress on expression of cyclophilin D and UCP2, genes controlling mitochondrial function, and the apoptotic genes caspase 3, Bax, and Bcl2...
  26. Geider K, Gernold M, Jock S, Wensing A, Völksch B, Gross J, et al. Unifying bacteria from decaying wood with various ubiquitous Gibbsiella species as G. acetica sp. nov. based on nucleotide sequence similarities and their acetic acid secretion. Microbiol Res. 2015;181:93-104 pubmed publisher
    ..Some strains were differentiated by the PFGE patterns of SpeI digests and by sequence analyses of the lsc and the ppiD genes, and the Chinese Gibbsiella strain was most divergent...
  27. Ishikita A, Matoba T, Ikeda G, Koga J, Mao Y, Nakano K, et al. Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocar. J Am Heart Assoc. 2016;5: pubmed publisher
    ..MOMP inhibition was also observed in cyclophilin D knockout (CypD-KO) mice, which lack the mitochondrial permeability transition pore (MPTP) opening...
  28. Marques Aleixo I, Santos Alves E, Balça M, Moreira P, Oliveira P, Magalhães J, et al. Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling. Mitochondrion. 2016;26:43-57 pubmed publisher
    ..Apoptotic signaling was followed through caspases 3, 8 and 9-like activities, Bax, Bcl2, CypD, ANT and cofilin expression...
  29. Waseem M, Ahmad F, Habib S, Gao Y, Li Z. Genome-wide identification of FK506-binding domain protein gene family, its characterization, and expression analysis in tomato (Solanum lycopersicum L.). Gene. 2018;678:143-154 pubmed publisher
  30. Quistgaard E, Weininger U, Ural Blimke Y, Modig K, Nordlund P, Akke M, et al. Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD. BMC Biol. 2016;14:82 pubmed
  31. Kim H, Oh Y, Kim K, Jeong S, Chon S, Kim D, et al. Cyclophilin A regulates JNK/p38-MAPK signaling through its physical interaction with ASK1. Biochem Biophys Res Commun. 2015;464:112-7 pubmed publisher
    ..Overall, we conclude that CypA negatively regulates ASK1 functions by its physical interaction with ASK1. ..
  32. Leitenbacher J, Herbach N. Age-related Qualitative Histological and Quantitative Stereological Changes in the Equine Pituitary. J Comp Pathol. 2016;154:215-24 pubmed publisher
    ..the equine pituitary and to identify features that allow distinction between pituitary pars intermedia dysfunction (PPID)-associated and non-functional/age-associated pars intermedia (PI) adenoma...
  33. Dawar F, Tu J, Khattak M, Mei J, Lin L. Cyclophilin A: A Key Factor in Virus Replication and Potential Target for Anti-viral Therapy. Curr Issues Mol Biol. 2017;21:1-20 pubmed
    ..Collectively, these facts demonstrate the critical roles of CypA in mediating or inhibiting viral infections, suggesting that CypA can be an attractive cellular target for the development of anti-viral therapy. ..
  34. Unsworth A, Bye A, Tannetta D, Desborough M, Kriek N, Sage T, et al. Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets. Arterioscler Thromb Vasc Biol. 2017;37:1482-1493 pubmed publisher
    ..species and intracellular calcium mobilization, and for FXR ligands, this process was found to be dependent on cyclophilin D. We conclude that treatment with LXR and FXR ligands initiates coated platelet formation, which is thought to ..
  35. Knowles E, Moreton Clack M, Shaw S, Harris P, Elliott J, Menzies Gow N. Plasma adrenocorticotropic hormone (ACTH) concentrations in ponies measured by two different assays suggests seasonal cross reactivity or interference. Equine Vet J. 2017;: pubmed publisher
    Analysis of plasma adrenocorticotropic hormone concentration [ACTH] aids diagnosis of pituitary pars intermedia dysfunction (PPID). Comparisons of validated chemiluminescent-immunoassay (CI) and immunofluorescent (IF) assays are limited.
  36. Yokoi H, Shimizu Y, Anazawa H, Lefebvre C, Korneluk R, Ikeda J. The structure and complete nucleotide sequence of the human cyclophilin 40 (PPID) gene. Genomics. 1996;35:448-55 pubmed
    b>Cyclophilin 40 is a recently identified member of the cyclophilin family that is found in an unactivated steroid hormone receptor complex...
  37. Storer Samaniego C, Suh J, Chattopadhyay A, Olivares K, Guy N, Sivils J, et al. The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling. PLoS ONE. 2015;10:e0134015 pubmed publisher
    ..However, the FKBP52 proline-rich loop that overhangs the PPIase pocket is critical for synergy. ..
  38. Caino M, Altieri D. Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy. Clin Cancer Res. 2016;22:540-5 pubmed publisher
    ..family compartmentalized in mitochondria, which suppress apoptosis via phosphorylation of the pore component, Cyclophilin D, and enable the subcellular repositioning of active mitochondria to membrane protrusions implicated in cell ..
  39. Fakharnia F, Khodagholi F, Dargahi L, Ahmadiani A. Prevention of Cyclophilin D-Mediated mPTP Opening Using Cyclosporine-A Alleviates the Elevation of Necroptosis, Autophagy and Apoptosis-Related Markers Following Global Cerebral Ischemia-Reperfusion. J Mol Neurosci. 2017;61:52-60 pubmed publisher
    ..Here, we aimed to evaluate the role of the cyclophilin D (CypD) as a prominent mediator of mPTP, on necroptosis and autophagy as well as apoptosis, beyond the global ..
  40. Mahoney B, Zhang M, Zintsmaster J, Peng J. Extended Impact of Pin1 Catalytic Loop Phosphorylation Revealed by S71E Phosphomimetic. J Mol Biol. 2018;430:710-721 pubmed publisher
    ..Our results suggest that S71 is a hub residue within an electrostatic network primed for phosphorylation, and may illustrate a common mechanism of phosphorylation-mediated allostery. ..
  41. Pearson J, Mohammed Z, Bacani J, Lai R, Ingham R. The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein. BMC Cancer. 2012;12:229 pubmed publisher
    ..Our preliminary findings suggested that expression of the immunophilin co-chaperone, Cyclophilin 40 (Cyp40), is up-regulated in ALK+ ALCL by JunB, a transcription factor activated by NPM-ALK signalling...
  42. Shirole N, Pal D, Kastenhuber E, Senturk S, Boroda J, Pisterzi P, et al. TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions. elife. 2016;5: pubmed publisher
    ..they promote tumor phenotypes by binding and activating the mitochondria inner pore permeability regulator, Cyclophilin D (CypD)...
  43. Sun F, Si Y, Bao H, Xu Y, Pan X, Zeng L, et al. Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice. Cell Mol Neurobiol. 2017;37:1457-1464 pubmed publisher
    ..cognitive dysfunction in the hippocampus induced by sepsis-associated encephalopathy (SAE) via acetylation of cyclophilin D (CypD) and opening of mitochondrial permeability transition pore...
  44. Shang W, Gao H, Lu F, Ma Q, Fang H, Sun T, et al. Cyclophilin D regulates mitochondrial flashes and metabolism in cardiac myocytes. J Mol Cell Cardiol. 2016;91:63-71 pubmed publisher
    b>Cyclophilin D (CyP-D) is the mitochondrial-specific member of the evolutionally conserved cyclophilin family, and plays an important role in the regulation of mitochondrial permeability transition (MPT) under stress...
  45. Harisseh R, Chiari P, Villedieu C, Sueur P, Abrial M, Fellahi J, et al. Cyclophilin D Modulates the Cardiac Mitochondrial Target of Isoflurane, Sevoflurane, and Desflurane. J Cardiovasc Pharmacol. 2017;69:326-334 pubmed publisher
    ..Mitochondria were shown to be major contributors to cardioprotection. Cyclophilin D (CypD) is one of the main regulators of mitochondria-induced cell death...
  46. Dongsheng Z, Zhiguang F, Junfeng J, Zifan L, Li W. Cyclophilin A Aggravates Collagen-Induced Arthritis via Promoting Classically Activated Macrophages. Inflammation. 2017;40:1761-1772 pubmed publisher
    ..Our findings provide evidence that PPIase CypA promoted macrophages polarization toward pro-inflammatory M1 phenotype via transcriptional activating NF-?B, thus leading to aggravated arthritis. ..
  47. Zhu H, Sun A. Programmed necrosis in heart disease: Molecular mechanisms and clinical implications. J Mol Cell Cardiol. 2018;116:125-134 pubmed publisher
    ..While MPT-dependent necrosis is another modality of necrosis characterized by MPT pore opening and cyclophilin-D (CypD)-dependent death signaling...
  48. Silverstein A, Galigniana M, Chen M, Owens Grillo J, Chinkers M, Pratt W. Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. J Biol Chem. 1997;272:16224-30 pubmed
    ..Thus, we propose that PP5 possesses properties of an immunophilin with low affinity FK506 binding activity and that it determines a major portion of the native GR heterocomplexes in L cell cytosol. ..
  49. Romano S, Xiao Y, Nakaya M, D Angelillo A, Chang M, Jin J, et al. FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma. Nucleic Acids Res. 2015;43:6983-93 pubmed publisher
    ..Our findings have profound implications for designing novel melanoma therapies based on modulation of FKBP51. ..
  50. Zhu X, Hogan S, Molkentin J, Zimmermann N. Cyclophilin D regulates necrosis, but not apoptosis, of murine eosinophils. Am J Physiol Gastrointest Liver Physiol. 2016;310:G609-17 pubmed publisher
    ..Recently, a peptidyl-prolyl isomerase located within the mitochondrial matrix, cyclophilin D (PPIF), was shown to regulate necrotic, but not apoptotic, cell death in vitro in fibroblasts, hepatocytes, ..
  51. Agallou M, Athanasiou E, Samiotaki M, Panayotou G, Karagouni E. Identification of Immunoreactive Leishmania infantum Protein Antigens to Asymptomatic Dog Sera through Combined Immunoproteomics and Bioinformatics Analysis. PLoS ONE. 2016;11:e0149894 pubmed publisher
    ..silico analysis predicted that the chaperonin HSP60, dihydrolipoamide dehydrogenase, enolase, cyclophilin 2, cyclophilin 40, and one hypothetical protein contain promiscuous MHCI and/or MHCII epitopes...
  52. Elkamhawy A, Park J, Hassan A, Ra H, Pae A, Lee J, et al. Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction. Eur J Med Chem. 2017;128:56-69 pubmed publisher
    ..Using CDocker algorithm, a molecular docking model presented a plausible binding mode for 5x with cyclophilin D (CypD) receptor as a major component of mPTP...
  53. Burstein S, Kim H, Fels J, Qian L, Zhang S, Zhou P, et al. Estrogen receptor beta modulates permeability transition in brain mitochondria. Biochim Biophys Acta Bioenerg. 2018;1859:423-433 pubmed publisher
    ..calcium threshold for MPT than male mitochondria, and that this sex difference depends on the MPT regulator cyclophilin D (CypD)...
  54. Bittner L, Westphal K, Narberhaus F. Conditional Proteolysis of the Membrane Protein YfgM by the FtsH Protease Depends on a Novel N-terminal Degron. J Biol Chem. 2015;290:19367-78 pubmed publisher
    ..The alarmone (p)ppGpp, but not the previously described YfgM interactors RcsB and PpiD, influence YfgM degradation...
  55. Fonai F, Priber J, Jakus P, Kalman N, Antus C, Pollak E, et al. Lack of cyclophilin D protects against the development of acute lung injury in endotoxemia. Biochim Biophys Acta. 2015;1852:2563-73 pubmed publisher
    ..Oxidative stress induces cyclophilin D (CypD)-dependent mitochondrial permeability transition (mPT), leading to organ failure in sepsis...
  56. Jacob S, Geor R, Weber P, Harris P, McCue M. Effect of dietary carbohydrates and time of year on ACTH and cortisol concentrations in adult and aged horses. Domest Anim Endocrinol. 2018;63:15-22 pubmed publisher
    Diagnosis of equine pituitary pars intermedia dysfunction (PPID) remains a challenge as multiple factors (stress, exercise, and time of year) influence ACTH and cortisol concentrations...
  57. Hoffmann K, Kakalis L, Anderson K, Armitage I, Handschumacher R. Expression of human cyclophilin-40 and the effect of the His141-->Trp mutation on catalysis and cyclosporin A binding. Eur J Biochem. 1995;229:188-93 pubmed
    ..NMR difference spectroscopy and molecular modelling revealed a cyclosporin-A-binding domain that is similar to that of CyP-18. ..
  58. Karch J, Kanisicak O, Brody M, Sargent M, Michael D, Molkentin J. Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death. PLoS ONE. 2015;10:e0130520 pubmed publisher
    ..Here, we show cells or mice deficient for Bax/Bak or cyclophilin D, a protein that regulates MPTP opening, are resistant to cell death induced by necroptotic mediators...
  59. Konstantakou E, Voutsinas G, Velentzas A, Basogianni A, Paronis E, Balafas E, et al. 3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants. Mol Cancer. 2015;14:135 pubmed publisher
    ..However, similarly to RIPK1 and CypD, p53 presented with non-essential contribution to 3-BrPA-induced cellular collapse, while reactivation of mutant ..
  60. Lu X, Kwong J, Molkentin J, Bers D. Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings. Circ Res. 2016;118:834-41 pubmed publisher
    ..suppressed by preventing mitochondrial Ca(2+) influx, by mPTP inhibitor cyclosporine A, sanglifehrin, and in cyclophilin D knockout mice. These tPTP events were 57±5 s in duration, but were rare (occurring in <0...
  61. Liu X, Wang C, Luo C, Sheng J, Wu D, Hu B, et al. Characterization of cyclophilin D in freshwater pearl mussel (Hyriopsis schlegelii). Zool Res. 2017;38:103-109 pubmed publisher
    b>Cyclophilin D (referred to as HsCypD) was obtained from the freshwater pearl mussel (Hyriopsis schlegelii). The full-length cDNA was 2 671 bp, encoding a protein consisting of 367 amino acids...
  62. Liu Z, Li L, Xue B. Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D. Eur J Pharmacol. 2018;824:72-77 pubmed publisher
    ..of colon cancer through the regulation of SIRT3 expression and whether this effect is related to acetylated cyclophilin D. The results demonstrated that GAD inhibits the energy reprogramming of colon cancer cells including glucose ..
  63. Dong Y, Zhuang Y, Cai W, Liu Y, Zou W. The mitochondrion interfering compound NPC-26 exerts potent anti-pancreatic cancer cell activity in vitro and in vivo. Tumour Biol. 2016;37:15053-15063 pubmed
    ..In summary, the results of this study suggest that NPC-26, alone or together with gemcitabine, potently inhibits pancreatic cancer cells possibly via disrupting mitochondrion. ..
  64. Honarpisheh M, Desai J, Marschner J, Weidenbusch M, Lech M, Vielhauer V, et al. Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis. Biosci Rep. 2016;36: pubmed publisher
    ..death domain (FADD), cellular inhibitor of apoptosis protein (CIAP)1, CIAP2, glutathione peroxidase-4 (GPX4), cyclophilin D (CYPD), CASP1, NLRP3 and poly(ADP-ribose) polymerase-1 (PARP1) in human and mouse solid organs...
  65. Zhao S, Chen C, Wang S, Ji F, Xie Y. MHY1485 activates mTOR and protects osteoblasts from dexamethasone. Biochem Biophys Res Commun. 2016;481:212-218 pubmed publisher
    ..Dex-induced mitochondrial death pathway activation, the latter was tested by mitochondrial depolarization, cyclophilin D-ANT-1 association and cytochrome C cytosol release...
  66. Ji C, Yang B, Yang Z, Tu Y, Yang Y, He L, et al. Ultra-violet B (UVB)-induced skin cell death occurs through a cyclophilin D intrinsic signaling pathway. Biochem Biophys Res Commun. 2012;425:825-9 pubmed publisher
    ..b>Cyclophilin D (Cyp-D) translocation to the inner membrane of mitochondrion acts as a key component to open the mPTP...
  67. Tavecchio M, Lisanti S, Lam A, Ghosh J, Martin N, O CONNELL M, et al. Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility. J Biol Chem. 2013;288:5553-61 pubmed publisher
    ..Here, we show that deletion or reduction in the levels of cyclophilin D (CypD, also called Ppif), a mitochondrial matrix peptidyl prolyl isomerase and apoptosis regulator, results in ..
  68. Schubert A, Grimm S. Cyclophilin D, a component of the permeability transition-pore, is an apoptosis repressor. Cancer Res. 2004;64:85-93 pubmed
    ..We also report that ANT-1's direct interactor, cyclophilin D, can specifically repress ANT-1-induced apoptosis...
  69. Machida K, Osada H. Molecular interaction between cyclophilin D and adenine nucleotide translocase in cytochrome c release: does it determine whether cytochrome c release is dependent on permeability transition or not?. Ann N Y Acad Sci. 2003;1010:182-5 pubmed
    ..permeability transition pore (MPTP) opening might be due to the Ca(2+)-dependent interaction between cyclophilin D and ANT...
  70. Machida K, Ohta Y, Osada H. Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells. J Biol Chem. 2006;281:14314-20 pubmed
    The permeability transition pore is involved in the mitochondrial pathway of apoptosis. Cyclophilin D, a pore component, has catalytic activity as a peptidyl prolyl cis, trans-isomerase (PPIase), which is essential to the pore opening...
  71. Radhakrishnan J, Bazarek S, Chandran B, Gazmuri R. Cyclophilin-D: a resident regulator of mitochondrial gene expression. FASEB J. 2015;29:2734-48 pubmed publisher
    ..Accordingly, these studies provide novel evidence that Cyp-D could play a key role in regulating mitochondrial gene expression. ..
  72. Blackburn E, Wear M, Landré V, Narayan V, Ning J, Erman B, et al. Cyclophilin40 isomerase activity is regulated by a temperature-dependent allosteric interaction with Hsp90. Biosci Rep. 2015;35: pubmed publisher
    b>Cyclophilin 40 (Cyp40) comprises an N-terminal cyclophilin domain with peptidyl-prolyl isomerase (PPIase) activity and a C-terminal tetratricopeptide repeat (TPR) domain that binds to the C-terminal-EEVD sequence common to both heat shock ..
  73. Peng X, Zhang D, Li Z, Fu M, Liu H. mTOR inhibition sensitizes human hepatocellular carcinoma cells to resminostat. Biochem Biophys Res Commun. 2016;477:556-562 pubmed publisher
    ..Together, these results suggest that mTOR could be a primary resistance factor of resminostat. Targeted inhibition of mTOR may thus significantly sensitize HCC cells to resminostat. ..
  74. Seufert F, Kuhn M, Hein M, Weiwad M, Vivoli M, Norville I, et al. Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei. Bioorg Med Chem. 2016;24:5134-5147 pubmed publisher
    ..Synthesis and evaluation of the compounds in PPIase assays resulted in highly active inhibitors. The activities can be interpreted in terms of a common binding mode obtained by docking calculations. ..
  75. Fu M, Shi W, Li Z, Liu H. Activation of mPTP-dependent mitochondrial apoptosis pathway by a novel pan HDAC inhibitor resminostat in hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2016;477:527-533 pubmed publisher
    ..The results of this preclinical study indicate that resminostat (or plus sorafenib) could be further investigated as a valuable anti-HCC strategy. ..
  76. Zhao H, Cui G, Jin J, Chen X, Xu B. Synthesis and Pin1 inhibitory activity of thiazole derivatives. Bioorg Med Chem. 2016;24:5911-5920 pubmed publisher
    ..38?M) was predicted using CDOCKER program. The results of this research would provide informative guidance for further optimizing thiazole derivatives as potent Pin1 inhibitors. ..
  77. Volk M, Maver A, Hodžić A, Lovrecic L, Peterlin B. Transcriptome Profiling Uncovers Potential Common Mechanisms in Fetal Trisomies 18 and 21. OMICS. 2017;21:565-570 pubmed publisher
    ..expressed genes in trisomies 18 and 21 revealed six dysregulated genes common to both: OTUD5, ADAMTSL1, TADA2A, PPID, PIAS2, and MAPRE2. These genes are involved in ubiquitination, protein folding, cell proliferation, and apoptosis...
  78. Linard D, Kandlbinder A, Degand H, Morsomme P, Dietz K, Knoops B. Redox characterization of human cyclophilin D: identification of a new mammalian mitochondrial redox sensor?. Arch Biochem Biophys. 2009;491:39-45 pubmed publisher
    ..b>Cyclophilin D, the only human mitochondrial isoform of cyclophilins, plays an essential role in the formation of the ..
  79. Shanmughapriya S, Rajan S, Hoffman N, Higgins A, Tomar D, Nemani N, et al. SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore. Mol Cell. 2015;60:47-62 pubmed publisher
    ..Loss of SPG7 resulted in higher mitochondrial Ca(2+) retention, similar to cyclophilin D (CypD, PPIF) knockdown with sustained ΔΨm during both Ca(2+) and ROS stress...
  80. Shinohe D, Kobayashi A, Gotoh M, Tanaka K, Ohta Y. Long-term inhibition of cyclophilin D results in intracellular translocation of calcein AM from mitochondria to lysosomes. Arch Biochem Biophys. 2017;613:53-60 pubmed publisher
    b>Cyclophilin D is a peptidyl-prolyl cis-trans isomerase localized in the mitochondrial matrix...
  81. Carmalt J, Scansen B. Development of two surgical approaches to the pituitary gland in the Horse. Vet Q. 2017;: pubmed publisher
    Current treatment of equine PPID requires daily oral medication, which is expensive and difficult from a management perspective...
  82. Lang A, Ernst K, Lee H, Papatheodorou P, Schwan C, Barth H, et al. The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens?ADP-ribosyltransferases. Cell Microbiol. 2014;16:490-503 pubmed publisher
    ..The Photorhabdus toxins interacted with Hsp90, FKBP51, Cyp40 and CypA, suggesting a role of these host cell factors in translocation and/or refolding of the ADP-ribosyltransferases. ..
  83. Hurst S, Hoek J, Sheu S. Mitochondrial Ca2+ and regulation of the permeability transition pore. J Bioenerg Biomembr. 2017;49:27-47 pubmed publisher
    ..We discuss the evidence for how Ca2+ regulates post-translational modification of cyclophilin D including phosphorylation by glycogen synthase kinase 3 beta, deacetylation by sirtuins, and oxidation/ ..
  84. Zhu Y, Gong Y, Li A, Chen M, Kang D, Liu J, et al. Differential Proteomic Analysis Reveals Protein Networks and Pathways that May Contribute to Helicobacter pylori FKBP-Type PPIase-Associated Gastric Diseases. Proteomics Clin Appl. 2017;: pubmed publisher
    ..pylori gene, peptidylprolyl isomerase-FK506 binding protein (PPIase-FKBP), and showed that PPIase-FKBP was capable of inducing oncogenic transformation of gastric epithelial cells. But its mechanism was unclear...
  85. Csizmok V, Montecchio M, Lin H, Tyers M, Sunnerhagen M, Forman Kay J. Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCFFbw7 Ubiquitin Ligase. Structure. 2018;26:28-39.e2 pubmed publisher
    ..Our findings support the general principle that multiple weak binding motifs within disordered regions can synergize to yield high-affinity interactions and provide rapidly evolvable means to build and fine-tune regulatory events. ..
  86. Ward B, Allan R, Mok D, Temple S, Taylor P, Dornan J, et al. A structure-based mutational analysis of cyclophilin 40 identifies key residues in the core tetratricopeptide repeat domain that mediate binding to Hsp90. J Biol Chem. 2002;277:40799-809 pubmed
    b>Cyclophilin 40 (CyP40) is a tetratricopeptide repeat (TPR)-containing immunophilin and a modulator of steroid receptor function through its binding to heat shock protein 90 (Hsp90)...
  87. McStay G, Clarke S, Halestrap A. Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore. Biochem J. 2002;367:541-8 pubmed
    ..The two effects together greatly sensitize the MPTP to [Ca(2+)]. ..
  88. Elrod J, Molkentin J. Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore. Circ J. 2013;77:1111-22 pubmed
    This review focuses on the role of cyclophilin D (CypD) as a prominent mediator of the mitochondrial permeability transition pore (MPTP) and subsequent effects on cardiovascular physiology and pathology...
  89. Baker J, Shelton L, Zheng D, Favretto F, Nordhues B, Darling A, et al. Human cyclophilin 40 unravels neurotoxic amyloids. PLoS Biol. 2017;15:e2001336 pubmed publisher
    ..Here we show that cyclophilin 40 (CyP40), a PPIase, dissolves tau amyloids in vitro...
  90. Kajitani K, Fujihashi M, Kobayashi Y, Shimizu S, Tsujimoto Y, Miki K. Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96-A resolution. Proteins. 2008;70:1635-9 pubmed
  91. Oh Y, Jeong K, Kim K, Lee Y, Jeong S, Kim S, et al. Cyclophilin B protects SH-SY5Y human neuroblastoma cells against MPP(+)-induced neurotoxicity via JNK pathway. Biochem Biophys Res Commun. 2016;478:1396-402 pubmed publisher
    ..The data suggest that overexpressed CypB protects neuronal cells from MPP+-induced dopaminergic neuronal cell death. ..
  92. Xu Y, Ma H, Fang Y, Zhang Z, Shao J, Hong M, et al. Cisplatin-induced necroptosis in TNF? dependent and independent pathways. Cell Signal. 2017;31:112-123 pubmed publisher
    ..Deficiency of cyclophilin-D (CypD) partially reduced cisplatin-induced cell death, indicating CypD mediated-mPTP opening plays an important role ..