PPFIA2

Summary

Gene Symbol: PPFIA2
Description: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Alias: liprin-alpha-2
Species: human

Top Publications

  1. ncbi Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting
    Michael Wyszynski
    Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuron 34:39-52. 2002
  2. ncbi Genome-wide association study of multiplex schizophrenia pedigrees
    Douglas F Levinson
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif, USA
    Am J Psychiatry 169:963-73. 2012
  3. pmc Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2
    Felicia Hawthorne
    Duke Center for Human Genetics, Duke University, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 54:2076-86. 2013
  4. ncbi Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins
    C Serra-Pages
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 273:15611-20. 1998
  5. ncbi Liprin-alpha2 gene, protein tyrosine phosphatase LAR interacting protein related gene, is downregulated by androgens in the human prostate cancer cell line LNCaP
    Kiyoshi Fujinami
    Department of Urology, Yokohama City University, Yokohama, Japan
    Int J Mol Med 10:173-6. 2002
  6. ncbi Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting
    Jaewon Ko
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 23:1667-77. 2003
  7. ncbi Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins
    Jaewon Ko
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:42377-85. 2003
  8. ncbi Identification and characterization of human PPFIA4 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:1009-14. 2003
  9. doi Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures
    Zhiyi Wei
    Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Mol Cell 43:586-98. 2011

Research Grants

  1. Genome-Wide Association Study of Schizophrenia
    Douglas Levinson; Fiscal Year: 2007
  2. GENETIC LINKAGE OF SCHIZOPHRENIA AND RELATED STUDIES
    Douglas Levinson; Fiscal Year: 2005
  3. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2007
  4. GENETICS OF RECURRENT EARLY-ONSET DEPRESSION
    Douglas Levinson; Fiscal Year: 2002
  5. Genetics of Early-Onset Depression
    Douglas Levinson; Fiscal Year: 2007
  6. Multicenter Genetics Studies of Schizophrenia
    Douglas Levinson; Fiscal Year: 2006
  7. MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2002
  8. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2002

Scientific Experts

  • DOUGLAS FREDERICK LEVINSON
  • Jaewon Ko
  • Felicia Hawthorne
  • Zhiyi Wei
  • Eunjoon Kim
  • Masuko Katoh
  • Jae Ran Lee
  • Seho Kim
  • Juli G Valtschanoff
  • Richard J Weinberg
  • Morgan Sheng
  • Kiyoshi Fujinami
  • Michael Wyszynski
  • Christopher J Hammond
  • Cristina Venturini
  • Pirro G Hysi
  • Sheng Feng
  • Yi Ju Li
  • Jeremy A Guggenheim
  • Ravikanth Metlapally
  • Patrick Calvas
  • David A Mackey
  • Francois Malecaze
  • Terri L Young
  • Khanh Nhat Tran-Viet
  • Thomas Rosenberg
  • Suilan Zheng
  • Mingjie Zhang
  • Samantha A Spangler
  • Casper C Hoogenraad
  • Cong Yu
  • C Serra-Pages
  • Moonseok Na
  • Masaru Katoh
  • Hyewon Shin
  • Richard T Premont
  • Hiroji Uemura
  • Anthone W Dunah
  • Yoshinobu Kubota
  • Carles Serra-Pages
  • Hitoshi Ishiguro
  • Maria Passafaro
  • Michel Streuli
  • Q G Medley
  • M Tang
  • M Streuli
  • A Hart

Detail Information

Publications9

  1. ncbi Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting
    Michael Wyszynski
    Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuron 34:39-52. 2002
    ..Thus, by mediating the targeting of liprin/GRIP-associated proteins, liprin-alpha is important for postsynaptic as well as presynaptic maturation...
  2. ncbi Genome-wide association study of multiplex schizophrenia pedigrees
    Douglas F Levinson
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif, USA
    Am J Psychiatry 169:963-73. 2012
    ..The authors used a genome-wide association study (GWAS) of multiply affected families to investigate the association of schizophrenia to common single-nucleotide polymorphisms (SNPs) and rare copy number variants (CNVs)...
  3. pmc Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2
    Felicia Hawthorne
    Duke Center for Human Genetics, Duke University, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 54:2076-86. 2013
    ..Myopia, or nearsightedness, is a common ocular genetic disease for which over 20 candidate genomic loci have been identified. The high-grade myopia locus, MYP3, has been reported on chromosome 12q21-23 by four independent linkage studies...
  4. ncbi Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins
    C Serra-Pages
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 273:15611-20. 1998
    ..We propose that liprins function to localize LAR family tyrosine phosphatases at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates...
  5. ncbi Liprin-alpha2 gene, protein tyrosine phosphatase LAR interacting protein related gene, is downregulated by androgens in the human prostate cancer cell line LNCaP
    Kiyoshi Fujinami
    Department of Urology, Yokohama City University, Yokohama, Japan
    Int J Mol Med 10:173-6. 2002
    ....
  6. ncbi Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting
    Jaewon Ko
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 23:1667-77. 2003
    ..These results suggest that the GIT1-liprin-alpha interaction is required for AMPA receptor targeting and that GIT1 may play an important role in the organization of presynaptic and postsynaptic multiprotein complexes...
  7. ncbi Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins
    Jaewon Ko
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:42377-85. 2003
    ..These results suggest that the interaction between ERC2 and liprin-alpha may be involved in the presynaptic localization of liprin-alpha and the molecular organization of presynaptic active zones...
  8. ncbi Identification and characterization of human PPFIA4 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:1009-14. 2003
    ..3, while exons 11-29 within AL451082.6. PPFIA4-MYOG locus (human chromosome 1q32.1) was paralogous to PPFIA2-LIN7A-MYF5-MYF6 locus (12q21.31), which was also paralogous to PPFIA3-LIN7B locus (19q13.41)...
  9. doi Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures
    Zhiyi Wei
    Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Mol Cell 43:586-98. 2011
    ..Finally, formation of the CASK/liprin-α/liprin-β ternary complex suggests that liprins can mediate assembly of target proteins into large protein complexes capable of regulating numerous cellular activities...

Research Grants29

  1. Genome-Wide Association Study of Schizophrenia
    Douglas Levinson; Fiscal Year: 2007
    ....
  2. GENETIC LINKAGE OF SCHIZOPHRENIA AND RELATED STUDIES
    Douglas Levinson; Fiscal Year: 2005
    ..abstract_text> ..
  3. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2007
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  4. GENETICS OF RECURRENT EARLY-ONSET DEPRESSION
    Douglas Levinson; Fiscal Year: 2002
    ..A timetable is proposed for rapid sharing of all biological materials, blinded clinical data, genotypes and linkage analyses with the scientific community through the NIMH-sponsored Center for Genetic Studies. ..
  5. Genetics of Early-Onset Depression
    Douglas Levinson; Fiscal Year: 2007
    ..abstract_text> ..
  6. Multicenter Genetics Studies of Schizophrenia
    Douglas Levinson; Fiscal Year: 2006
    ....
  7. MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2002
    ..These studies may assist investigators in determining which candidate regions are most deserving of intensive efforts to find disease-related genes, and the most likely locations of these genes within the regions. ..
  8. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2002
    ..Power analyses suggest that this study would have excellent power to detect loci associated with lambda sibs of 1.4, and moderate power for a value of 1.3, i.e., loci with relatively small etiologic effects. ..