Gene Symbol: PPCDC
Description: phosphopantothenoylcysteine decarboxylase
Alias: MDS018, PPC-DC, coaC, phosphopantothenoylcysteine decarboxylase
Species: human
Products:     PPCDC

Top Publications

  1. Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, De Crecy Lagard V, et al. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. J Biol Chem. 2002;277:21431-9 pubmed
    ..the last four enzymatic steps in CoA biosynthesis: phosphopantothenoylcysteine synthetase (EC ), phosphopantothenoylcysteine decarboxylase (EC ), phosphopantetheine adenylyltransferase (EC ), and dephospho-CoA kinase (EC )...
  2. Santolaria C, Velázquez D, Strauss E, Arino J. Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function. Sci Rep. 2018;8:14701 pubmed publisher
    ..joins ScCab3 (and in some instances the Hal3 paralog Vhs3) to form an unusual heterotrimeric phosphopantothenoylcysteine decarboxylase (PPCDC) enzyme...
  3. Fletcher S, Lucantoni L, Sykes M, Jones A, Holleran J, Saliba K, et al. Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway. Parasit Vectors. 2016;9:589 pubmed
    ..The most active compound targeted either phosphopantothenoylcysteine synthetase (PPCS) or phosphopantothenoylcysteine decarboxylase (PPCDC)...
  4. Nurkanto A, Jeelani G, Yamamoto T, Naito Y, Hishiki T, Mori M, et al. Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target. Int J Parasitol Drugs Drug Resist. 2018;8:125-136 pubmed publisher
    ..7.1.33), bifunctional phosphopantothenate-cysteine ligase/decarboxylase (PPCS-PPCDC), phosphopantetheine adenylyltransferase (PPAT) and dephospho-CoA kinase (DPCK)...
  5. Arya R, ESCALANTE A, Farook V, Restrepo J, Battafarano D, Almeida M, et al. A genetic association study of carotid intima-media thickness (CIMT) and plaque in Mexican Americans and European Americans with rheumatoid arthritis. Atherosclerosis. 2018;271:92-101 pubmed publisher
    ..The top association for CIMT was observed with rs1867148 (PPCDC gene, ? ± SE = -0.28 ± 0.06, p = 5.11 × 10-6)...
  6. Strauss E, Zhai H, Brand L, McLafferty F, Begley T. Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent. Biochemistry. 2004;43:15520-33 pubmed
    b>Phosphopantothenoylcysteine decarboxylase (PPC-DC) catalyzes the decarboxylation of the cysteine moiety of 4'-phosphopantothenoylcysteine (PPC) to form 4'-phosphopantetheine (PPantSH); this reaction forms part of the biosynthesis of ..
  7. Manoj N, Ealick S. Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase. Acta Crystallogr D Biol Crystallogr. 2003;59:1762-6 pubmed
    ..Thus, the true space group is R3 with four monomers per asymmetric unit. ..
  8. Cornelis M, Monda K, Yu K, Paynter N, Azzato E, Bennett S, et al. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genet. 2011;7:e1002033 pubmed publisher
    ..4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2. ..
  9. Abrie J, Molero C, Ariño J, Strauss E. Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3. Sci Rep. 2015;5:15774 pubmed publisher
    ..protein phosphatase Ppz1 and as subunits (together with Cab3) of the unique heterotrimeric phosphopantothenoylcysteine decarboxylase (PPCDC) enzyme of Hemiascomycetous yeast...