Gene Symbol: PPARGC1B
Description: PPARG coactivator 1 beta
Alias: ERRL1, PERC, PGC-1(beta), PGC1B, peroxisome proliferator-activated receptor gamma coactivator 1-beta, PGC-1-related estrogen receptor alpha coactivator, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, PPARgamma coactivator 1 beta, peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Species: human
Products:     PPARGC1B

Top Publications

  1. Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman B. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem. 2002;277:1645-8 pubmed
    ..HCF is shown to bind to both PGC-1alpha and -1beta and augment their transcriptional activity. ..
  2. Kressler D, Schreiber S, Knutti D, Kralli A. The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J Biol Chem. 2002;277:13918-25 pubmed
    ..Because of its nuclear receptor selectivity, we have termed the new protein PERC (PGC-1 related Estrogen Receptor Coactivator)...
  3. Meirhaeghe A, Crowley V, Lenaghan C, Lelliott C, Green K, Stewart A, et al. Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. Biochem J. 2003;373:155-65 pubmed
    ..These results suggest that PGC1 beta may play a role in constitutive adrenergic-independent mitochondrial biogenesis. ..
  4. Wirtenberger M, Tchatchou S, Hemminki K, Schmutzhard J, Sutter C, Schmutzler R, et al. Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer. Carcinogenesis. 2006;27:2201-8 pubmed
    ..transcription factor, which activates gene expression through recruiting multiple coactivators, such as PPARGC1A, PPARGC1B and EP300...
  5. Patti M, Butte A, Crunkhorn S, Cusi K, Berria R, Kashyap S, et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A. 2003;100:8466-71 pubmed
    ..in diabetic subjects, expression of both PPAR gamma coactivator 1-alpha and-beta (PGC1-alpha/PPARGC1 and PGC1-beta/PERC), coactivators of NRF-1 and PPAR gamma-dependent transcription, is decreased in both diabetic subjects and family ..
  6. Kressler D, Hock M, Kralli A. Coactivators PGC-1beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen. J Biol Chem. 2007;282:26897-907 pubmed
    ..Our findings suggest that tamoxifen-induced changes in the ERalpha LBD promote interactions with the coactivator PGC-1beta, which then cooperates with SRC-1 to enable tamoxifen agonism. ..
  7. Dong X, Xu M, Ren Z, Gu J, Lu M, Lu Q, et al. Regulation of CBL and ESR1 expression by microRNA-22?3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma. Int J Mol Med. 2016;38:446-56 pubmed publisher
    ..E3 ubiquitin protein ligase (CBL), peroxisome proliferator?activated receptor gamma, coactivator 1 beta (PPARGC1B), and estrogen receptor 1 (ESR1) that are targeted by these miRNAs were increased (p<0.01)...
  8. Fujita H, Yagishita N, Aratani S, Saito Fujita T, Morota S, Yamano Y, et al. The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β. EMBO J. 2015;34:1042-55 pubmed publisher
    ..Thus, SYVN1 is a novel post-translational regulator of PGC-1β and a potential therapeutic target in obesity treatment. ..
  9. Hsu C, Cho Y, Wu W, Lien S, Zhang X, Zhu W, et al. Enhanced Si Passivation and PERC Solar Cell Efficiency by Atomic Layer Deposited Aluminum Oxide with Two-step Post Annealing. Nanoscale Res Lett. 2019;14:139 pubmed publisher
    ..Finally, the passivated emitter and rear cell conversion efficiency was improved from 21.61% by using an industry annealing process to 21.97% by using the two-step annealing process. ..

More Information

Publications148 found, 100 shown here

  1. Knyazev E, Zakharova G, Astakhova L, Tsypina I, Tonevitsky A, Sukhikh G. Metabolic Reprogramming of Trophoblast Cells in Response to Hypoxia. Bull Exp Biol Med. 2019;166:321-325 pubmed publisher
    ..a core hypoxia response genes along with up-regulation of NOS3, PDK1, and BNIP3 genes and down-regulation of the PPARGC1B gene...
  2. Zhu M, Lu T, Jia Y, Luo X, Gopal P, Li L, et al. Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease. Cell. 2019;177:608-621.e12 pubmed publisher
    ..Additional ultra-deep sequencing identified recurrent mutations in PKD1, PPARGC1B, KMT2D, and ARID1A...
  3. Sperling S, Fiedler P, Lechner M, Pollithy A, Ehrenberg S, Schiefer A, et al. Chronic CD30-signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells. Blood. 2019;: pubmed publisher
    ..These mice displayed an increase of B1 cells in the peritoneal cavity (PerC) and in secondary lymphoid organs as well as increased numbers of plasma cells (PC)...
  4. Yeates K, Tang K, Barrowman N, Freedman S, Gravel J, Gagnon I, et al. Derivation and initial validation of clinical phenotypes of children presenting with concussion acutely in the Emergency Department: Latent class analysis of a multicentre, prospective cohort, observational study. J Neurotrauma. 2019;: pubmed publisher
    ..August 2013 until June 2015 at 9 pediatric Emergency Departments within the Pediatric Emergency Research Canada (PERC) network. This sub-study included 2323 children from the original cohort ages 8.00 to 17...
  5. Arpón A, Riezu Boj J, Milagro F, Marti A, Razquin C, Martínez González M, et al. Adherence to Mediterranean diet is associated with methylation changes in inflammation-related genes in peripheral blood cells. J Physiol Biochem. 2016;73:445-455 pubmed publisher
    ..Eight genes related to inflammation and immunocompetence (EEF2, COL18A1, IL4I1, LEPR, PLAGL1, IFRD1, MAPKAPK2, PPARGC1B) were finally selected as changes in their methylation levels correlated with adherence to MedDiet and because ..
  6. Sen H, Seckiner I, Bayrak O, Erturhan S, DemirbaÄŸ A. Treatment alternatives for urinary system stone disease in preschool aged children: results of 616 cases. J Pediatr Urol. 2015;11:34.e1-5 pubmed publisher
    ..In our study, we used adult PNL instruments in the early period, whereas mini-PERC was performed in the later years. The success rate in PNL group was found as 85%...
  7. Hallenborg P, Fjære E, Liaset B, Petersen R, Murano I, Sonne S, et al. p53 regulates expression of uncoupling protein 1 through binding and repression of PPARγ coactivator-1α. Am J Physiol Endocrinol Metab. 2016;310:E116-28 pubmed publisher
    ..This was related to an increased expression of Ucp1 and other PPARGC1a and PPARGC1b target genes but not Ppargc1a or Ppargc1b in inguinal white adipose tissue of mice lacking TRP53...
  8. Duffy D, Zhu G, Li X, Sanna M, Iles M, Jacobs L, et al. Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nat Commun. 2018;9:4774 pubmed publisher
    ..results with a recent melanoma GWAS meta-analysis (12,874 cases, 23,203 controls), SNPs near GPRC5A, CYP1B1, PPARGC1B, HDAC4, FAM208B, DOCK8, and SYNE2 reached global significance, and other loci, including MIR146A and OBFC1, ..
  9. Musztyfaga Staszuk M, Putynkowski G, Socha R, Stodolny M, Panek P. Copper-Based Volumetric Filler Dedicated for Ag Paste for Depositing the Front Electrodes by Printing on Solar Si Cells. Materials (Basel). 2018;11: pubmed publisher
    ..conventional cell structures such as aluminum-back surface field (Al-BSF) and passivated emitter and rear contact (PERC), and finally solar cells with front electrodes deposited by screen-printing method were fabricated and ..
  10. Ramos Benítez M, Ruiz Jiménez C, Rosado Franco J, Ramos Perez W, Mendez L, Osuna A, et al. Fh15 Blocks the Lipopolysaccharide-Induced Cytokine Storm While Modulating Peritoneal Macrophage Migration and CD38 Expression within Spleen Macrophages in a Mouse Model of Septic Shock. mSphere. 2018;3: pubmed publisher
    ..ii) concurrently, Fh15 increased the population of large peritoneal macrophages (LPMs) in the peritoneal cavity (PerC) of LPS-injected animals, and (iii) Fh15 downregulated the expression on spleen macrophages of CD38, a cell surface ..
  11. McCarthy N, Vangjeli C, Surendran P, Treumann A, Rooney C, Ho E, et al. Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Atherosclerosis. 2018;269:42-49 pubmed publisher
    ..The strongest associations were in PPARGC1B (rs4235745, rs32582, rs10515638) and CNTN4 (rs10510230, rs4684343), these 5 single nucleotide polymorphisms (SNPs)..
  12. Zhou J, Ma J, Mo Y, Zheng D, Chen L, Wei X, et al. Down-regulating peroxisome proliferator-activated receptor-gamma coactivator-1 beta alleviates the proinflammatory effect of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting extracellular signal-regulated kinase, p38 and nuclear f. Arthritis Res Ther. 2014;16:472 pubmed publisher
    ..D) PGC-1β mediated NF-κB transcription in RA-FLS, but did not affect ERK and p38. The results indicate that PGC-1β may play important roles in the proinflammatory effects and apoptosis of RA-FLS. ..
  13. Tzanavari T, Varela A, Theocharis S, Ninou E, Kapelouzou A, Cokkinos D, et al. Metformin protects against infection-induced myocardial dysfunction. Metabolism. 2016;65:1447-58 pubmed publisher
    ..LPS caused marked reduction of the cardiac metabolism-related genes tested, including Prkaa2, Cpt1b, Ppargc1a and Ppargc1b; reduction of fatty acid oxidation, as reflected by the regulation of Ppara, Acaca and Acacb; increased glucose ..
  14. Song L, Rini C, Deal A, Nielsen M, Chang H, Kinneer P, et al. Improving couples' quality of life through a Web-based prostate cancer education intervention. Oncol Nurs Forum. 2015;42:183-92 pubmed publisher
    ..newly developed web-based, couple-oriented intervention called Prostate Cancer Education and Resources for Couples (PERC). Quantitative, qualitative, mixed-methods approach...
  15. Endo C, Johnson T, Morino R, Nakazono K, Kamitsuji S, Akita M, et al. Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations. Sci Rep. 2018;8:8974 pubmed publisher
    ..1?×?10-22), HSPA12A (rs12259842; P?=?7.1?×?10-11), PPARGC1B (rs251468; P?=?1.3?×?10-21), and RAB11FIP2 (rs10444039; P?=?5.6?×?10-21)...
  16. Yanaral F, Ozgor F, Kucuktopcu O, Sarilar O, Ayranci A, Savun M, et al. Comparison of Flexible Ureterorenoscopy and Mini Percutaneous Nephrolithotomy in the Management of Multiple Renal Calculi in 10-30 mm Size. Urol J. 2018;: pubmed publisher
    To evaluate the efficacy and safety of flexible ureterorenoscopy (f-URS) and mini percutaneous nephrolithotomy (mini-perc) in the management of 10-30 millimeter multiple renal stones...
  17. Valckx S, De Bie J, Michiels E, Goovaerts I, Punjabi U, Ramos Ibeas P, et al. The effect of human follicular fluid on bovine oocyte developmental competence and embryo quality. Reprod Biomed Online. 2015;30:203-7 pubmed publisher
    ..1). The addition of follicular fluid also altered bovine blastocyst gene expression. Furthermore, LDHA and PPARGC1B gene expression differed between follicular fluid groups...
  18. Zeng R, Faccio R, Novack D. Alternative NF-κB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms. J Bone Miner Res. 2015;30:2287-99 pubmed publisher
    ..PGC-1β (Ppargc1b) expression, but not PGC-1α, PPRC1, or ERRα, was significantly reduced in RelB(-/-) and NIK(-/-) OCs...
  19. Stojanovska J, Carlos R, Kocher K, Nagaraju A, Guy K, Kelly A, et al. CT Pulmonary Angiography: Using Decision Rules in the Emergency Department. J Am Coll Radiol. 2015;12:1023-9 pubmed publisher
    ..angiography (CTPA), comparing two commonly applied decision rules, the pulmonary embolism (PE) rule-out criteria (PERC) and the modified Wells criteria (mWells), in the emergency department (ED) setting...
  20. Obuchowski N, Buckler A, Kinahan P, Chen Mayer H, Petrick N, Barboriak D, et al. Statistical Issues in Testing Conformance with the Quantitative Imaging Biomarker Alliance (QIBA) Profile Claims. Acad Radiol. 2016;23:496-506 pubmed publisher
    ..three examples to illustrate the process: apparent diffusion coefficient in solid tumors measured by MRI, change in Perc 15 as a biomarker for the progression of emphysema, and percent change in solid tumor volume by computed tomography ..
  21. Ramos E, Ramos D, Moreira G, Macchione M, Guimarães E, Rodrigues F, et al. Viscoelastic properties of bronchial mucus after respiratory physiotherapy in subjects with bronchiectasis. Respir Care. 2015;60:724-30 pubmed publisher
    Previous studies have evaluated the effectiveness of postural drainage (PD), percussion (PERC), the coughing technique (CT), and other types of coughing in subjects with bronchiectasis...
  22. Chen M, Chang J, Lin Y, Pan K, Ho W, Liu W, et al. Deciphering the gene expression profile of peroxisome proliferator-activated receptor signaling pathway in the left atria of patients with mitral regurgitation. J Transl Med. 2016;14:157 pubmed publisher
    ..expressions of APOA1, ACADM, FABP3, ETFDH, ECH1, CPT1B, CPT2, SLC27A6, ACAA2, SMARCD3, SORBS1, EHHADH, SLC27A1, PPARGC1B, PPARA and CPT1A were significantly up-regulated, whereas the expression of PLTP was significantly down-regulated ..
  23. Nickels K, Thibert R, Rau S, Demarest S, Wirrell E, Kossoff E, et al. How do we diagnose and treat epilepsy with myoclonic-atonic seizures (Doose syndrome)? Results of the Pediatric Epilepsy Research Consortium survey. Epilepsy Res. 2018;144:14-19 pubmed publisher
    ..The EMAS focus group of PERC created a survey to assess the opinions of pediatric neurologists who care for children with EMAS regarding ..
  24. Dalaijamts C, Cichocki J, Luo Y, Rusyn I, Chiu W. Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice. Toxicol Appl Pharmacol. 2018;352:142-152 pubmed publisher
    Perchloroethylene (perc) induced target organ toxicity has been associated with tissue-specific metabolic pathways...
  25. Nahon K, Doornink F, Straat M, Botani K, Martinez Tellez B, Abreu Vieira G, et al. Effect of sitagliptin on energy metabolism and brown adipose tissue in overweight individuals with prediabetes: a randomised placebo-controlled trial. Diabetologia. 2018;61:2386-2397 pubmed publisher
    ..In skeletal muscle, sitagliptin increased mRNA expression of PGC1β (also known as PPARGC1B) (+117%; p < 0.05), a main controller of mitochondrial oxidative energy metabolism...
  26. Abe M, Xie W, Regan M, King I, Stampfer M, Kantoff P, et al. Single-nucleotide polymorphisms within the antioxidant defence system and associations with aggressive prostate cancer. BJU Int. 2011;107:126-34 pubmed publisher
    ..defence: glutathione peroxidase (GPX1, GPX4), peroxisome proliferator-activated receptor ? coactivator (PPARGC1A, PPARGC1B), SOD1, SOD2, and SOD3, and 'X-ray repair complementing defective repair in Chinese hamster cell 1' (XRCC1)...
  27. De Coster O, Forget P, Moens M, Matic M, Choustoulakis L, Poelaert J. A new minimally invasive technique for lead revision of perc-paddle leads. Acta Neurochir (Wien). 2018;160:831-833 pubmed publisher
    ..An Epiducer can be used to revise the SCS system in a minimal invasive way without a new puncture. Follow-up study of this technique as well as others for revising an SCS system should be encouraged and used in comparison study. ..
  28. Sweeney T, Suliman H, Hollingsworth J, Welty Wolf K, Piantadosi C. A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis. PLoS ONE. 2011;6:e25249 pubmed publisher
    ..This includes the metabolic and mitochondrial biogenesis master co-activators, Ppargc1a (PGC-1?) and Ppargc1b (PGC-1?) in Staphylococcus aureus (S. aureus) sepsis...
  29. Noureldin Y, Fahmy N, Anidjar M, Andonian S. Is there a place for virtual reality simulators in assessment of competency in percutaneous renal access?. World J Urol. 2016;34:733-9 pubmed publisher
    ..PCA competency of each participant was assessed objectively by performing task 4 on the PERC Mentorâ„¢ simulator, where they had to correctly access and pop 7 balloons in 7 different renal calyces and ..
  30. Beckford R, Howard S, Das S, Farmer A, Campagna S, Yu J, et al. Maternal consumption of fish oil programs reduced adiposity in broiler chicks. Sci Rep. 2017;7:13129 pubmed publisher
    ..adipocyte profile was paralleled by upregulated expression of the adipogenic regulator PPARG and its co-activator PPARGC1B, and reduced expression of LPL...
  31. Huss J, Kopp R, Kelly D. Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. J Biol Chem. 2002;277:40265-74 pubmed
  32. Akhmetov I, Popov D, Missina S, Vinogradova O, Rogozkin V. [The analysis of PPARGC1B gene polymorphism in athletes]. Ross Fiziol Zh Im I M Sechenova. 2009;95:1247-53 pubmed
    ..investigate allelic distribution of the peroxisome proliferator-activated receptor gamma coactivator 1beta gene (PPARGC1B; Ala203Pro polymorphism) in athletes (n = = 1535) and controls (n = 1113), and to find interrelation between ..
  33. Bozarth A, Bajaj N, Wessling M, Keffer D, Jallu S, Salzman G. Evaluation of the pulmonary embolism rule-out criteria in a retrospective cohort at an urban academic hospital. Am J Emerg Med. 2015;33:483-7 pubmed publisher
    The pulmonary embolism rule-out criteria (PERC) is an 8-variable clinical decision rule that identifies patients at low risk for pulmonary embolism (PE) to prevent unnecessary diagnostic testing in the evaluation of suspected PE in the ..
  34. Bialy L, Plint A, Zemek R, Johnson D, Klassen T, Osmond M, et al. Pediatric Emergency Research Canada: Origins and Evolution. Pediatr Emerg Care. 2018;34:138-144 pubmed publisher
    ..The success of Pediatric Emergency Research Canada (PERC) is described in terms of advancing the pediatric emergency medicine agenda, grant funding, peer-reviewed ..
  35. Brinkmann G, Norvang V, Norli E, Grøvle L, Haugen A, Lexberg A, et al. Treat to target strategy in early rheumatoid arthritis versus routine care - A comparative clinical practice study. Semin Arthritis Rheum. 2019;48:808-814 pubmed publisher
    ..The T2T cohort included 293 patients (mean (SD) age 54 (13) years, 66% females, disease duration median (25,75 perc) 98 (57,164) days) and the routine care cohort 392 patients (age 54 (13) years, 68% females, 4 (0,30) days since ..
  36. Hirose T, Tanaka Y, Tanaka A, Sakai H, Sasaki Y, Shinohara N, et al. PD-L1/PD-L2-expressing B-1 cells inhibit alloreactive T cells in mice. PLoS ONE. 2017;12:e0178765 pubmed publisher
    ..Either splenic B cells, peritoneal cavity (PerC) B cells, or non-B cells from Balb/c mice were intravenously injected into B6 mice...
  37. Zhai N, Sun C, Gu W, He X, Shan A, Sun H, et al. Resistance to high-fat diet-induced obesity in male heterozygous Pprc1 knockout mice. Endocr J. 2015;62:633-44 pubmed publisher
    ..Other than the well-characterized Pgc1a and Pgc1b that act as regulators of mitochondrial biogenesis and oxidative metabolism, the function of Pprc1 in vivo is ..
  38. Hennelly K, Baskin M, Monuteuax M, Hudgins J, Kua E, Commeree A, et al. Detection of Pulmonary Embolism in High-Risk Children. J Pediatr. 2016;178:214-218.e3 pubmed publisher
    ..We evaluated the test characteristics of the Wells criteria and Pulmonary Embolism Rule-out Criteria (PERC) low-risk rule and used recursive partition analysis to derive a clinical decision rule...
  39. Sun D, Sahu B, Gao S, Schur R, Vaidya A, Maeda A, et al. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis. Mol Ther Nucleic Acids. 2017;7:42-52 pubmed publisher
    ..because of their intrinsic properties of pH-sensitive amphiphilic endosomal escape and reductive cytosolic release (PERC)...
  40. Kline J, Ellison A, Kanis J, Pike J, Hall C. Evaluation of the pulmonary embolism rule out criteria (PERC rule) in children evaluated for suspected pulmonary embolism. Thromb Res. 2018;168:1-4 pubmed publisher
    The pulmonary embolism rule out criteria (PERC) reliably predicts a low probability of PE in adults. We examine the diagnostic accuracy of the objective components of the PERC rule in children previously tested for PE...
  41. Nan H, Kraft P, Qureshi A, Guo Q, Chen C, Hankinson S, et al. Genome-wide association study of tanning phenotype in a population of European ancestry. J Invest Dermatol. 2009;129:2250-7 pubmed publisher
    ..Overall, these tanning ability-related loci are similar to the hair color-related loci previously reported in the GWAS of hair color. ..
  42. Kripke D, Kline L, Nievergelt C, Murray S, Shadan F, Dawson A, et al. Genetic variants associated with sleep disorders. Sleep Med. 2015;16:217-24 pubmed publisher
    ..In peroxisome proliferator-activated receptor gamma, coactivator 1 beta (PPARGC1B), rs6888451 was associated with several markers of obstructive sleep apnea...
  43. Andreadou I, Bibli S, Mastromanolis E, Zoga A, Efentakis P, Papaioannou N, et al. Transient carotid ischemia as a remote conditioning stimulus for myocardial protection in anesthetized rabbits: Insights into intracellular signaling. Int J Cardiol. 2015;184:140-51 pubmed publisher
    We investigated the effectiveness of perconditioning (Perc) applied at different time points along with the role of RISK, SAFE, STAT5 and eNOS pathways. Anesthetized rabbits were subjected to 30-min ischemia/3-hour reperfusion...
  44. Goldman N, Valiuskyte K, Londregan J, Swider A, Somerville J, Riggs J. Macrophage regulation of B cell proliferation. Cell Immunol. 2017;314:54-62 pubmed publisher
    ..We model the TME by culturing peritoneal cavity (PerC) cells that naturally have a high macrophage to lymphocyte ratio...
  45. Zhu L, Huang Q, Xie Z, Kang M, Ding H, Chen B, et al. PPARGC1A rs3736265 G>A polymorphism is associated with decreased risk of type 2 diabetes mellitus and fasting plasma glucose level. Oncotarget. 2017;8:37308-37320 pubmed publisher
    ..g. PPARGC1A and PPARGC1B) are key agents in the development and pathophysiology of type 2 diabetes mellitus (T2DM)...
  46. Liesa M, Borda d Agua B, Medina Gomez G, Lelliott C, Paz J, Rojo M, et al. Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta. PLoS ONE. 2008;3:e3613 pubmed publisher
    ..In addition, we describe a novel role of PGC-1beta in mitochondrial physiology, namely the control of mitochondrial fusion mainly through Mfn2. ..
  47. Petrov P, Palou A, Bonet M, Ribot J. Cell-Autonomous Brown-Like Adipogenesis of Preadipocytes From Retinoblastoma Haploinsufficient Mice. J Cell Physiol. 2016;231:1941-52 pubmed publisher
    ..conditions increased glucose uptake and an enhanced expression of brown adipocyte-related genes (Pparg, Ppargc1a, Ppargc1b, Prdm16, Cpt1b) but not of purported beige/brite transcriptional markers (Cd137, Tmem26, Tbx1, Slc27a1, Hoxc9, ..
  48. Cichocki J, Furuya S, Konganti K, Luo Y, McDonald T, Iwata Y, et al. Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice. J Pharmacol Exp Ther. 2017;361:17-28 pubmed publisher
    ..We examined the effect of NAFLD on toxicokinetics of tetrachloroethylene (PERC), a ubiquitous environmental contaminant that requires metabolic activation to induce adverse health effects...
  49. Petr M, Stastny P, Zajac A, Tufano J, Maciejewska Skrendo A. The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review. Int J Mol Sci. 2018;19: pubmed publisher
    ..receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators' (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance ..
  50. He Z, Hu Y, Li Y, Gong L, Cieszczyk P, Maciejewska Karlowska A, et al. PGC-related gene variants and elite endurance athletic status in a Chinese cohort: a functional study. Scand J Med Sci Sports. 2015;25:184-95 pubmed publisher
    ..Genotype distributions of 133 SNPs in PPARGC1A, PPARGC1B, PPRC1, TFAM, TFB1M, TFB2M, NRF1, GABPA, GABPB1, ERRα, and SIRT1 genes were compared between 235 elite Chinese ..
  51. Teixeira N, Rojas T, da Silveira W, Matheus Guimarães C, Silva N, Scaletsky I. Genetic analysis of enteropathogenic Escherichia coli (EPEC) adherence factor (EAF) plasmid reveals a new deletion within the EAF probe sequence among O119 typical EPEC strains. BMC Microbiol. 2015;15:200 pubmed publisher
    ..22 of which belonged to O119 serogroup, presented a 1652 pb deletion in the region between 1093-bp downstream perC and 616-bp of the EAF fragment. The bfpA, bfpG, and per genes were found in all typical strains...
  52. Dias C, Menezes H, Cardeal Z. Use of exhaled air as an improved biomonitoring method to assess perchloroethylene short-term exposure. Environ Res. 2017;156:108-112 pubmed publisher
    This paper shows the use of exhaled air as a biomonitoring method to assess perchloroethylene (PERC) environmental and occupational exposure...
  53. Mullerova D, Pesta M, Dvorakova J, Cedíková M, Kulda V, Dvorak P, et al. Polychlorinated biphenyl 153 in lipid medium modulates differentiation of human adipocytes. Physiol Res. 2017;66:653-662 pubmed
    ..in lipid vehicle was associated with down regulation of key master genes of adipogenesis: PPARgamma, SREBP-1, PPARGC1B, and PLIN2 during the whole process of differentiation; and with increased Akt and decreased Phospho-Akt protein ..
  54. Wang L, Liu Q, Li F, Qiu J, Fan H, Ma H, et al. Apoptosis induced by PGC-1? in breast cancer cells is mediated by the mTOR pathway. Oncol Rep. 2013;30:1631-8 pubmed publisher
    ..These results provide new evidence that cell apoptosis is orchestrated by the balance between several signaling pathways, and that PGC-1? takes part in these events in breast cancer cells mediated by the mTOR signaling pathway. ..
  55. Kauvar D, Martin E, Givens M. Thirty-Day Outcomes after Elective Percutaneous or Open Endovascular Repair of Abdominal Aortic Aneurysms. Ann Vasc Surg. 2016;31:46-51 pubmed publisher
    ..surgical exposure of the femoral artery for access (OPEN) were compared with those completed without such exposure (PERC)...
  56. Troynikov O, Watson C, Jadhav A, Nawaz N, Kettlewell R. Towards sustainable and safe apparel cleaning methods: A review. J Environ Manage. 2016;182:252-264 pubmed publisher
    Perchloroethylene (PERC) is a compound commonly used as a solvent in dry cleaning, despite its severe health and environmental impacts...
  57. Kumazoe M, Takai M, Hiroi S, Takeuchi C, Kadomatsu M, Nojiri T, et al. The FOXO3/PGC-1? signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma. J Biol Chem. 2017;292:10813-10823 pubmed publisher
    ..This suggests that cGMP induction and PGC-1? inhibition represent potential strategies for treating patients with pancreatic ductal adenocarcinoma. ..
  58. Ma L, Qiu H, Chen Z, Li L, Zeng Y, Luo J, et al. miR-25 modulates triacylglycerol and lipid accumulation in goat mammary epithelial cells by repressing PGC-1beta. J Anim Sci Biotechnol. 2018;9:48 pubmed publisher
    ..Taken together, our results show miR-25 is potentially involved in lipid metabolism and we reveal the function of the miR-25/PGC-1beta regulatory axis during lactation. ..
  59. Madsen T, Jedick R, Teeples T, Carlson M, Steenblik J. Impact of altitude-adjusted hypoxia on the Pulmonary Embolism Rule-out Criteria. Am J Emerg Med. 2019;37:281-285 pubmed publisher
    The Pulmonary Embolism Rule-out Criteria (PERC) defines hypoxia as an oxygen saturation (O2 sat) < 95%...
  60. Strekalova T, Costa Nunes J, Veniaminova E, Kubatiev A, Lesch K, Chekhonin V, et al. Insulin receptor sensitizer, dicholine succinate, prevents both Toll-like receptor 4 (TLR4) upregulation and affective changes induced by a high-cholesterol diet in mice. J Affect Disord. 2016;196:109-16 pubmed publisher
    ..measures of anxiety/depression, and Tlr4 and peroxisome-proliferator-activated-receptor-gamma coactivator-1b (PPARGC1b) expression...
  61. Hsu C, Yang C, Wang Y, Huang C, Lien S, Kung C, et al. Low Cost Local Contact Opening by Using Polystyrene Spheres Spin-Coating Method for PERC Solar Cells. Materials (Basel). 2016;9: pubmed publisher
    The passivated emitter and rear cell (PERC) concept is one of the most promising technologies for increasing crystalline silicon solar cell efficiency...
  62. Frizell A, Fogel N, Steenblik J, Carlson M, Bledsoe J, Madsen T. Prevalence of pulmonary embolism in patients presenting to the emergency department with syncope. Am J Emerg Med. 2018;36:253-256 pubmed publisher
    ..with a PE at the time of the ED visit or during the follow-up period were Pulmonary Embolism Rule Out Criteria (PERC) positive and reported shortness of breath in the ED...
  63. Drescher M, Fried J, Brass R, Medoro A, Murphy T, Delgado J. Knowledge Translation of the PERC Rule for Suspected Pulmonary Embolism: A Blueprint for Reducing the Number of CT Pulmonary Angiograms. West J Emerg Med. 2017;18:1091-1097 pubmed publisher
    ..We studied a department-endorsed, evidence-based clinical protocol that included the PE rule-out criteria (PERC) rule, multi-modal education using principles of knowledge translation (KT), and clinical decision support embedded ..
  64. Hara K, Tobe K, Okada T, Kadowaki H, Akanuma Y, Ito C, et al. A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. Diabetologia. 2002;45:740-3 pubmed
    ..The Thr394Thr - Gly482Ser haplotype was associated with Type II diabetes (p = 0.00003). CONCLUSION/INTERPRETATION. The results of this study suggested that the PGC-1 gene might be implicated in the pathogenesis of Type II diabetes. ..
  65. Victorino V, Barroso W, Assunção A, Cury V, Jeremias I, Petroni R, et al. PGC-1β regulates HER2-overexpressing breast cancer cells proliferation by metabolic and redox pathways. Tumour Biol. 2016;37:6035-44 pubmed publisher
    ..In conclusion, we show an association of HER2-overexpression and PGC-1β. PGC-1β knockdown impairs HER2-overexpressing cells proliferation acting on ERRα signaling, metabolism, and redox balance. ..
  66. Wood M, Goldman N, DePierri K, Somerville J, Riggs J. Erythropoietin increases macrophage-mediated T cell suppression. Cell Immunol. 2016;306-307:17-24 pubmed publisher
    ..the high macrophage to lymphocyte ratio found in tumor microenvironments (TMEs) by culturing peritoneal cavity (PerC) cells that naturally have a high macrophage to T cell ratio...
  67. Valli H, Ahmad S, Fraser J, Jeevaratnam K, Huang C. Pro-arrhythmic atrial phenotypes in incrementally paced murine Pgc1?-/- hearts: effects of age. Exp Physiol. 2017;102:1619-1634 pubmed publisher
    ..aged (>52 week) wild-type (WT) and peroxisome proliferative activated receptor, gamma, coactivator 1 beta (Ppargc1b)-deficient (Pgc1?-/- ) Langendorff-perfused hearts, previously used to model mitochondrial energetic ..
  68. Shiraki T, Sakai N, Kanaya E, Jingami H. Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state. J Biol Chem. 2003;278:11344-50 pubmed
    ..These results indicate that PGC-1 alpha mediates the ligand-independent activation of CAR by means of subnuclear targeting through the RS domain of PGC-1 alpha. ..
  69. Lee S, Jang A, Woo Park S, Park J, Kim Y, Uh S, et al. Genetic effect of single-nucleotide polymorphisms in the PPARGC1B gene on airway hyperreactivity in asthmatic patients. Clin Exp Allergy. 2011;41:1533-44 pubmed publisher
    Peroxisome proliferator-activated receptor gamma coactivator 1 beta (PPARGC1B) is a co-activator for intracellular receptors such as the estrogen receptor, PPAR, and glucocorticoid receptor, which are involved in asthma development...
  70. Riehle C, Abel E. PGC-1 proteins and heart failure. Trends Cardiovasc Med. 2012;22:98-105 pubmed publisher
    ..Here, we discuss the regulation of PGC-1 proteins under conditions of pressure overload hypertrophy and heart failure. ..
  71. Cho Y, Hazen B, Russell A, Kralli A. Peroxisome proliferator-activated receptor ? coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. J Biol Chem. 2013;288:25207-18 pubmed publisher
    ..Elucidating the function of Perm1 may enable novel approaches for the treatment of disorders with compromised skeletal muscle bioenergetics, such as mitochondrial myopathies and age-related/disease-associated muscle atrophies. ..
  72. Galmés Pascual B, Nadal Casellas A, Bauzá Thorbrügge M, Sbert Roig M, Garcia Palmer F, Proenza A, et al. 17?-estradiol improves hepatic mitochondrial biogenesis and function through PGC1B. J Endocrinol. 2017;232:297-308 pubmed
    ..mitochondrial biogenesis and function, but little is known about the different contribution of hepatic PGC1A and PGC1B in these processes...
  73. Goldman N, Lomakova Y, Londregan J, Bucknum A, DePierri K, Somerville J, et al. High macrophage PD-L1 expression not responsible for T cell suppression. Cell Immunol. 2018;324:50-58 pubmed publisher
    ..Peritoneal cavity (PerC) cell culture reproduces key features of TMEs as lymphocyte proliferation is suppressed by PerC macrophages (Mϕs)...
  74. Kelly C, Agy C, Carlson M, Steenblik J, Bledsoe J, Hartsell S, et al. Family history of venous thromboembolism predicts the diagnosis of acute pulmonary embolism in the emergency department. Am J Emerg Med. 2018;36:1550-1554 pubmed publisher
    ..2% vs. 1.6% (p?=?0.009). 82.3% of patients were Pulmonary Embolism Rule-out Criteria (PERC) positive, and among PERC-positive patients, those with a family history of VTE were more likely to be diagnosed ..
  75. Srivastava S, Diaz F, Iommarini L, Aure K, Lombes A, Moraes C. PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders. Hum Mol Genet. 2009;18:1805-12 pubmed publisher
    ..These results reinforce the concept that increased mitochondrial biogenesis is a promising venue for the treatment of mitochondrial diseases. ..
  76. Browne G, Dragon J, Hong D, Messier T, Gordon J, Farina N, et al. MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells. Tumour Biol. 2016;37:8825-39 pubmed publisher
    ..of Runx1 in late-stage breast cancer cells resulted in increased expression of both the miR-378 host gene PPARGC1B and pre-miR-378, suggesting a feedback loop...
  77. Freund Y, Rousseau A, Guyot Rousseau F, Claessens Y, Hugli O, Sanchez O, et al. PERC rule to exclude the diagnosis of pulmonary embolism in emergency low-risk patients: study protocol for the PROPER randomized controlled study. Trials. 2015;16:537 pubmed publisher
    ..The Pulmonary Embolism Rule-out Criteria (PERC) is an eight-item block of clinical criteria that can identify patients who can safely be discharged from the ED ..
  78. Booker M, Johnson J. Optimizing CT Pulmonary Angiogram Utilization in a Community Emergency Department: A Pre- and Postintervention Study. J Am Coll Radiol. 2017;14:65-71 pubmed publisher
    ..2% in the pre- and postintervention groups, respectively. Similarly, the workup of patients based on retrospective PERC and Wells-score criteria did not significantly improve after the intervention...
  79. Handschin C, Spiegelman B. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev. 2006;27:728-35 pubmed
    ..Recent studies have elucidated the function of the PGC-1 coactivators in different tissues and have highlighted the implications of PGC-1 dysregulation in diseases such as diabetes, obesity, cardiomyopathy, or neurodegeneration. ..
  80. Oelsner K, Guo Y, To S, Non A, Barkin S. Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity. BMC Genomics. 2017;18:57 pubmed publisher
    ..Furthermore, eight of the 17 CpG sites reside in genes (FSTL1, SORCS2, NRF1, DLC1, PPARGC1B, CHN2, NXPH1) that have prior known associations with obesity, diabetes, and the insulin pathway...
  81. Alix Panabières C, Cayrefourcq L, Mazard T, Maudelonde T, Assenat E, Assou S. Molecular Portrait of Metastasis-Competent Circulating Tumor Cells in Colon Cancer Reveals the Crucial Role of Genes Regulating Energy Metabolism and DNA Repair. Clin Chem. 2017;63:700-713 pubmed publisher
    ..receptor γ coactivator 1A (PPARGC1A), peroxisome proliferator-activated receptor γ coactivator 1B (PPARGC1B), fatty acid binding protein 1 (FABP1), aldehyde dehydrogenase 3 family member A1 (ALDH3A1)], ..
  82. Kline J. Diagnosis and Exclusion of Pulmonary Embolism. Thromb Res. 2018;163:207-220 pubmed publisher
    ..for PE or a Wells score<2, they can reasonably exclude PE with the Pulmonary Embolism Rule out Criteria (PERC rule)...
  83. Wible R, Tran Q, Fathima S, Sutter C, Kensler T, Sutter T. Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo. Mol Pharmacol. 2018;93:297-308 pubmed publisher
    ..Although both compounds modify Keap1 to affect canonical cytoprotective gene expression, additional unique sets of Nrf2-dependent genes were regulated by each agent with enrichment of selective metabolic pathways. ..
  84. Knutti D, Kaul A, Kralli A. A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol Cell Biol. 2000;20:2411-22 pubmed
    ..Our findings suggest a regulatory function for hPGC-1 as a tissue-specific coactivator for a subset of nuclear receptors. ..
  85. Shoag J, Haq R, Zhang M, Liu L, Rowe G, Jiang A, et al. PGC-1 coactivators regulate MITF and the tanning response. Mol Cell. 2013;49:145-57 pubmed publisher
    ..These data identify PGC-1 coactivators as regulators of human tanning. ..
  86. Wen Y, Hao J, Xiao X, Wang W, Guo X, Lin W, et al. PPARGC1B gene is associated with Kashin-Beck disease in Han Chinese. Funct Integr Genomics. 2016;16:459-63 pubmed publisher
    ..The genetic basis of KBD remains elusive now. To investigate the relationship between PPARGC1B gene polymorphism and KBD, we conducted a two-stage association study using 2743 unrelated Han Chinese subjects...
  87. Pesce V, Nicassio L, Fracasso F, Musicco C, Cantatore P, Gadaleta M. Acetyl-L-carnitine activates the peroxisome proliferator-activated receptor-? coactivators PGC-1?/PGC-1?-dependent signaling cascade of mitochondrial biogenesis and decreases the oxidized peroxiredoxins content in old rat liver. Rejuvenation Res. 2012;15:136-9 pubmed publisher
    ..Furthermore, a remarkable decline of Drp1 and of Mfn2 proteins is reported here for the first time, suggesting a reduced mitochondrial dynamics in aging liver with no effect of ALCAR treatment. ..
  88. Li X, Liu H, Amos C, Lee J, Thomas N, Wei Q, et al. A PGC1? genetic variant associated with nevus count and melanoma mortality. Int J Cancer. 2017;141:1066-1067 pubmed publisher
  89. Luo Y, Cichocki J, McDonald T, Rusyn I. Simultaneous detection of the tetrachloroethylene metabolites S-(1,2,2-trichlorovinyl) glutathione, S-(1,2,2-trichlorovinyl)-L-cysteine, and N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine in multiple mouse tissues via ultra-high performance liquid chro. J Toxicol Environ Health A. 2017;80:513-524 pubmed publisher
    Tetrachloroethylene (perchloroethylene; PERC) is a high-production volume chemical and ubiquitous environmental contaminant that is hazardous to human health...
  90. Esterbauer H, Oberkofler H, Krempler F, Patsch W. Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics. 1999;62:98-102 pubmed
    ..Hence, PPARGC1 expression might influence insulin sensitivity as well as energy expenditure, thereby contributing to the development and pathophysiology of human obesity. ..
  91. Ek J, Andersen G, Urhammer S, Gaede P, Drivsholm T, Borch Johnsen K, et al. Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. Diabetologia. 2001;44:2220-6 pubmed
    ..0007). No interaction between this variant and the Pro12Ala polymorphism of PPAR-gamma2 was observed. A widespread Gly482Ser polymorphism of PGC-1 is associated with a 1.34 genotype relative risk of Type II diabetes. ..
  92. Mellies J, Platenkamp A, Osborn J, Ben Avi L. PerC Manipulates Metabolism and Surface Antigens in Enteropathogenic Escherichia coli. Front Cell Infect Microbiol. 2017;7:32 pubmed publisher
    ..The pEAF plasmid encodes an attachment factor as well as a regulatory operon, perABC. PerC, a poorly understood regulator, was previously shown to regulate expression of the type III secretion system ..