Gene Symbol: PP1
Description: protein phosphatase 1 catalytic subunit alpha
Alias: PP-1A, PP1A, PP1alpha, PPP1A, serine/threonine-protein phosphatase PP1-alpha catalytic subunit, protein phosphatase 1, catalytic subunit, alpha isoform, protein phosphatase 1, catalytic subunit, alpha isozyme, serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit, testicular tissue protein Li 155
Species: human
Products:     PP1

Top Publications

  1. Ammosova T, Jerebtsova M, Beullens M, Voloshin Y, Ray P, Kumar A, et al. Nuclear protein phosphatase-1 regulates HIV-1 transcription. J Biol Chem. 2003;278:32189-94 pubmed
    We recently reported that protein phosphatase 1 (PP1) dephosphorylates RNA polymerase II C-terminal repeats and regulates HIV-1 transcription in vitro...
  2. Jin Q, Van Eynde A, Beullens M, Roy N, Thiel G, Stalmans W, et al. The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor. J Biol Chem. 2003;278:30677-85 pubmed
    ..Nucleic acids also decreased the potency of NIPP1 as an inhibitor of PP1, but they did not prevent the formation of a ternary NIPP1.EED.PP1 complex...
  3. Li L, Ren C, Tahir S, Ren C, Thompson T. Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. Mol Cell Biol. 2003;23:9389-404 pubmed
    ..We subsequently found that cav-1 interacts with and inhibits serine/threonine protein phosphatases PP1 and PP2A through scaffolding domain binding site interactions...
  4. Ceulemans H, Vulsteke V, De Maeyer M, Tatchell K, Stalmans W, Bollen M. Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. J Biol Chem. 2002;277:47331-7 pubmed
    Functional studies of the protein phosphatase-1 (PP1) regulator Sds22 suggest that it is indirectly and/or directly involved in one of the most ancient functions of PP1, i.e...
  5. Bharucha D, Zhou M, Nekhai S, Brady J, Shukla R, Kumar A. A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat. Virology. 2002;296:6-16 pubmed
    ..The Tat-associated protein phosphatase (TAPP) is related to the serine/threonine, type 1, protein phosphatase (PP1) family...
  6. Wang W, Stukenberg P, Brautigan D. Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells. Mol Biol Cell. 2008;19:4852-62 pubmed publisher
    ..These defects did not involve changes in levels of protein phosphatase-1 (PP1), and the multinuclear phenotype was rescued by overexpression of I-2...
  7. Hsieh Wilson L, Allen P, Watanabe T, Nairn A, Greengard P. Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1. Biochemistry. 1999;38:4365-73 pubmed
    Protein phosphatase-1 (PP1) plays an important role in a variety of cellular processes, including muscle contraction, cell-cycle progression, and neurotransmission...
  8. Cohen P. Protein phosphatase 1--targeted in many directions. J Cell Sci. 2002;115:241-56 pubmed
    Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase that regulates an enormous variety of cellular functions through the interaction of its catalytic subunit (PP1c) with over fifty different established ..
  9. Ammosova T, Washington K, Debebe Z, Brady J, Nekhai S. Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription. Retrovirology. 2005;2:47 pubmed
    ..In the present study we analyze relative contribution of PP2A and PP1 to dephosphorylation of CDK9 and to HIV-1 transcription in vitro and in vivo...

More Information


  1. Takahashi M, Shibata H, Shimakawa M, Miyamoto M, Mukai H, Ono Y. Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus. J Biol Chem. 1999;274:17267-74 pubmed
  2. Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, et al. NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. J Biol Chem. 2000;275:25411-7 pubmed
    NIPP1 is a regulatory subunit of a species of protein phosphatase-1 (PP1) that co-localizes with splicing factors in nuclear speckles...
  3. Ayllon V, Cayla X, Garcia A, Fleischer A, Rebollo A. The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. Eur J Immunol. 2002;32:1847-55 pubmed
    Bcl-xL and Bcl-w specifically interact with PP1alpha and Bad. A phosphatase activity sensitive to okadaic acid was detected in Bcl-xL, Bcl-w and Bad immunoprecipitates...
  4. Steen R, Martins S, Tasken K, Collas P. Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly. J Cell Biol. 2000;150:1251-62 pubmed
    Subcellular targeting of cAMP-dependent protein kinase (protein kinase A [PKA]) and of type 1 protein phosphatase (PP1) is believed to enhance the specificity of these enzymes...
  5. Ragusa M, Dancheck B, Critton D, Nairn A, Page R, Peti W. Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites. Nat Struct Mol Biol. 2010;17:459-64 pubmed publisher
    The serine/threonine protein phosphatase 1 (PP1) dephosphorylates hundreds of key biological targets. PP1 associates with >or=200 regulatory proteins to form highly specific holoenzymes...
  6. Lesage B, Beullens M, Pedelini L, Garcia Gimeno M, Waelkens E, Sanz P, et al. A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3. Biochemistry. 2007;46:8909-19 pubmed
    Protein Ser/Thr phosphatase-1 (PP1) associates with a host of proteins to form substrate-specific holoenzymes. Sds22 and Inhibitor-3 (I3) are two independently described ancient interactors of PP1...
  7. Nawa M, Kanekura K, Hashimoto Y, Aiso S, Matsuoka M. A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Cell Signal. 2008;20:493-505 pubmed
    ..Given its ubiquitous expression, BTBD10 appears to behave as a suppressor of cell death including neuronal cell death related to ALS and an enhancer of cell growth via its positive regulation of Akt phosphorylation. ..
  8. Schmutz I, Wendt S, Schnell A, Kramer A, Mansuy I, Albrecht U. Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. PLoS ONE. 2011;6:e21325 pubmed publisher
    ..Here, we identify protein phosphatase 1 (PP1) as regulator of period and light-induced resetting of the mammalian circadian clock...
  9. Kuehnen P, Laubner K, Raile K, Schofl C, Jakob F, Pilz I, et al. Protein phosphatase 1 (PP-1)-dependent inhibition of insulin secretion by leptin in INS-1 pancreatic β-cells and human pancreatic islets. Endocrinology. 2011;152:1800-8 pubmed publisher
  10. Van Dessel N, Beke L, Görnemann J, Minnebo N, Beullens M, Tanuma N, et al. The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets. Nucleic Acids Res. 2010;38:7500-12 pubmed publisher
    ..Here, we show that NIPP1, a regulator of protein Ser/Thr phosphatase-1 (PP1), forms a complex with PP1 and PRC2 components on chromatin...
  11. Durfee T, Becherer K, Chen P, Yeh S, Yang Y, Kilburn A, et al. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 1993;7:555-69 pubmed
    ..Cell cycle synchrony experiments revealed that this association occurs from mitosis to early G1. The implications of these findings on the regulation of both proteins are discussed. ..
  12. Liu C, Lv X, Li T, Xu Y, Zhou X, Zhao S, et al. PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. J Biol Chem. 2011;286:5558-66 pubmed publisher
    ..Here, we identified PP1 as a bona fide TAZ phosphatase. PP1A dephosphorylates TAZ at Ser-89 and Ser-311, promotes TAZ nuclear translocation, and stabilizes TAZ by disrupting ..
  13. Allen P, Kwon Y, Nairn A, Greengard P. Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit. J Biol Chem. 1998;273:4089-95 pubmed
    Protein phosphatase 1 (PP1) is found in the cell nucleus and has been implicated in several aspects of nuclear function...
  14. Schillace R, Scott J. Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220. Curr Biol. 1999;9:321-4 pubmed
    The cyclic AMP (cAMP)-dependent protein kinase (PKA) and the type 1 protein phosphatase (PP1) are broad-specificity signaling enzymes with opposing actions that catalyze changes in the phosphorylation state of cellular proteins...
  15. Tanuma N, Kim S, Beullens M, Tsubaki Y, Mitsuhashi S, Nomura M, et al. Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155). J Biol Chem. 2008;283:35805-14 pubmed publisher
    ..Recent work has revealed essential roles for Ser/Thr phosphatases, such as protein phosphatase-1 (PP1), in splicing, but how these phosphatases are regulated is largely unknown...
  16. Ammosova T, Jerebtsova M, Beullens M, Lesage B, Jackson A, Kashanchi F, et al. Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein. J Biol Chem. 2005;280:36364-71 pubmed
    ..We previously showed that Tat-induced HIV-1 transcription is regulated by protein phosphatase-1 (PP1)...
  17. Chen R, Liu M, Li H, Xue Y, Ramey W, He N, et al. PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. Genes Dev. 2008;22:1356-68 pubmed publisher
    ..alone is insufficient, and PP2B must act sequentially and cooperatively with protein phosphatase 1alpha (PP1alpha) to disrupt 7SK snRNP...
  18. Kim Y, Bourgeois C, Isel C, Churcher M, Karn J. Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation. Mol Cell Biol. 2002;22:4622-37 pubmed
    ..We conclude that phosphorylation of the RNA polymerase II CTD by CDK9 enhances transcription elongation directly. ..
  19. Kelker M, Page R, Peti W. Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors. J Mol Biol. 2009;385:11-21 pubmed publisher
    ..Many naturally occurring, molecular toxins modulate PP1 activity, though the exact mechanism of this differential regulation is not understood...
  20. Winter S, Bosnoyan Collins L, Pinnaduwage D, Andrulis I. The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors. BMC Cancer. 2007;7:85 pubmed
    ..Additionally, Real-Time PCR was utilized to determine the expression of BRCA1, PP1alpha, beta and gamma in primary human breast tumors and normal breast tissue to identify alterations in the expression ..
  21. Liu Y, Virshup D, White R, Hsu L. Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. Cancer Res. 2002;62:6357-61 pubmed
    ..Data presented here show that both recombinant protein phosphatase 1 alpha (PP1alpha) catalytic subunit and endogenous PP1alpha dephosphorylate GST-BF4-P. Inhibitor 2 abolishes this activity...
  22. Jerebtsova M, Klotchenko S, Artamonova T, Ammosova T, Washington K, Egorov V, et al. Mass spectrometry and biochemical analysis of RNA polymerase II: targeting by protein phosphatase-1. Mol Cell Biochem. 2011;347:79-87 pubmed publisher
    ..We previously reported that protein phosphatase-1 (PP1) dephosphorylates RNAPII CTD in vitro and inhibition of nuclear PP1-blocked viral transcription...
  23. Farinelli M, Heitz F, Grewe B, Tyagarajan S, Helmchen F, Mansuy I. Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection. PLoS ONE. 2012;7:e34047 pubmed publisher
    ..We identified the protein Ser/Thr phosphatase protein phosphatase-1 (PP1), an enzyme associated with glutamate receptors, as a key trigger of survival pathways that can prevent neuronal ..
  24. Wu J, Wang J, Jiang X, Lan J, He X, Wang H, et al. MiR-125b promotes cell migration and invasion by targeting PPP1CA-Rb signal pathways in gastric cancer, resulting in a poor prognosis. Gastric Cancer. 2015;18:729-39 pubmed publisher
    ..MiR-125b not only promotes cellular proliferation, migration, and invasion in vitro, but also acts as an independent prognostic factor in gastric cancer. ..
  25. Li X, Lin H, Chen H, Xu X, Shih H, Ann D. SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. Sci Signal. 2010;3:ra32 pubmed publisher
    ..Here, we found that, whereas the protein phosphatase 1alpha isoform (PP1alpha) directly interacted with KAP1 under basal conditions, PP1beta interacted with KAP1 only in response to genotoxic ..
  26. Barber M, Hendrickx A, Beullens M, Ceulemans H, Oxley D, Thelen S, et al. The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1?. Biochem J. 2012;443:173-83 pubmed publisher
    ..In the present study we show that PP1? (protein phosphatase 1?) binds P-Rex1 through an RVxF-type docking motif...
  27. Carrey E, Campbell D, Hardie D. Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis. EMBO J. 1985;4:3735-42 pubmed
    ..The physiological role of this phosphorylation in the stimulation of cell proliferation by growth factors and other mitogens is discussed. ..
  28. Sung H, Yang H, Zhang H, Yang Q, Hu N, Tang Z, et al. Common genetic variants in epigenetic machinery genes and risk of upper gastrointestinal cancers. Int J Epidemiol. 2015;44:1341-52 pubmed publisher
    ..Results of our analyses provide limited but suggestive evidence for a role of epigenetic gene variation in the aetiology of UGI cancer. ..
  29. Monshausen M, Rehbein M, Richter D, Kindler S. The RNA-binding protein Staufen from rat brain interacts with protein phosphatase-1. J Neurochem. 2002;81:557-64 pubmed
    ..Cellular functions of Staufen may be regulated via phosphorylation or Staufen may recruite the phosphatase into specific ribonucleoprotein complexes. ..
  30. Wies E, Wang M, Maharaj N, Chen K, Zhou S, Finberg R, et al. Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling. Immunity. 2013;38:437-49 pubmed publisher
    ..Employing a phosphatome RNAi screen, we identified PP1? and PP1? as the primary phosphatases that are responsible for MDA5 and RIG-I dephosphorylation and that lead to ..
  31. Carey G, Roy S, Daino H. The natural tumorcide Manumycin-A targets protein phosphatase 1α and reduces hydrogen peroxide to induce lymphoma apoptosis. Exp Cell Res. 2015;332:136-45 pubmed publisher
    ..Pre-treatment with Calyculin-A, an equipotent inhibitor of PP1 and PP2A, blocked all downstream effects of Man-A whereas, the PP2A-selective inhibitor, Okadaic acid did not, ..
  32. Chen P, Li C, Wang D, Luo Z, Fu S, Li X, et al. PP-1? and PP-1? display antagonism and differential roles in tumorigenicity of lung cancer cells. Curr Mol Med. 2013;13:220-7 pubmed
    ..In the present study, we demonstrated that in lung cancer 1299 cells, PP1? and PP- 1 & ? exist in an antagonizing balance...
  33. Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A. A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta. J Biol Chem. 2002;277:36955-61 pubmed
    ..Cyclic AMP-dependent protein kinase (PKA) and type 1 protein phosphatase (PP1) were also detected in this complex, suggesting that AKAP220, GSK-3beta, PKA, and PP1 form a quaternary complex...
  34. Kwon Y, Huang H, Desdouits F, Girault J, Greengard P, Nairn A. Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins. Proc Natl Acad Sci U S A. 1997;94:3536-41 pubmed
  35. Chen C, Weng S, Tseng P, Lin H, Chen C. Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes. J Biol Chem. 2005;280:38879-87 pubmed
    ..dephosphorylation in U87MG glioblastoma and PC-3 prostate cancer cells by disrupting HDAC-protein phosphatase 1 (PP1) complexes...
  36. Lobbestael E, Zhao J, Rudenko I, Beylina A, Gao F, Wetter J, et al. Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle. Biochem J. 2013;456:119-28 pubmed publisher
    ..Therefore we aimed to identify the phosphatase for LRRK2. Using a panel of recombinant phosphatases, we found that PP1 (protein phosphatase 1) efficiently dephosphorylates LRRK2 in vitro...
  37. Jérôme M, Paudel H. 14-3-3? regulates nuclear trafficking of protein phosphatase 1? (PP1?) in HEK-293 cells. Arch Biochem Biophys. 2014;558:28-35 pubmed publisher
    Protein phosphatase 1 (PP1) is one of the major Ser/Thr phosphatases in mammalian cells. There are four isoforms of PP1 namely, PP1?, PP1?/?, PP1?1 and PP1?2...
  38. Nagarajan S, Vohra T, Loffing J, Faresse N. Protein Phosphatase 1α enhances renal aldosterone signaling via mineralocorticoid receptor stabilization. Mol Cell Endocrinol. 2017;450:74-82 pubmed publisher
    ..Here, we identified Protein Phosphatase 1 alpha (PP1α), as a novel cytoplasmic binding partner of MR that promotes the receptor activity...
  39. Lu Z, Wan G, Guo H, Zhang X, Lu X. Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx. Cell Signal. 2013;25:796-804 pubmed publisher
    ..In the present study, we identify protein phosphatase 1 (PP1) as a negative regulator in the p53 signaling pathway...
  40. Colbran R, Bass M, McNeill R, Bollen M, Zhao S, Wadzinski B, et al. Association of brain protein phosphatase 1 with cytoskeletal targeting/regulatory subunits. J Neurochem. 1997;69:920-9 pubmed
    ..Size-exclusion chromatography of solubilized extracts separated two main PP1 activities (approximately 600 and approximately 100 kDa)...
  41. Brems Eskildsen A, Zieger K, Toldbod H, Holcomb C, Higuchi R, Mansilla F, et al. Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts. BMC Cancer. 2010;10:646 pubmed publisher
    ..The detection rate improved when including cytology results, but also the combination of hTERT and MCM5 increased the detection rate. Furthermore, hTERT and MCM5 levels predicted subsequent tumor recurrences. ..
  42. Gong C, Wegiel J, Lidsky T, Zuck L, Avila J, Wisniewski H, et al. Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. Brain Res. 2000;853:299-309 pubmed
    ..These results suggest that PP2A might be the major PP that participates in regulation of the phosphorylation of MAP1b and MAP2 and their biological activities. ..
  43. Orth M, Mayer B, Rehm K, Rothweiler U, Heidmann D, Holak T, et al. Shugoshin is a Mad1/Cdc20-like interactor of Mad2. EMBO J. 2011;30:2868-80 pubmed publisher
    ..Mad2 binding is conserved in the only known Xenopus laevis shugoshin homologue and, compatible with a putative meiotic function, the interaction occurs in oocytes. ..
  44. Santoro M, Gaudino G, Villa Moruzzi E. Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor. Biochem J. 2003;376:587-94 pubmed
    ..32)P]H(3)PO(4) metabolic labelling, we found that Ron is serine-phosphorylated and dephosphorylated in vitro by PP1 (protein phosphatase 1). PP1 associates with Ron obtained from cells of different origins...
  45. Chen B, Huang C, Lin Y, Huang C, Deng C, Hsu L. The K898E germline variant in the PP1-binding motif of BRCA1 causes defects in DNA Repair. Sci Rep. 2014;4:5812 pubmed publisher
    ..We have demonstrated that protein phosphatase 1? (PP1?) interacts with BRCA1 via a PP1-binding motif (898)KVTF(901), and can dephosphorylate multiple serine residues ..
  46. Alrehani N, Pradhan S, Khatlani T, Kailasam L, Vijayan K. Distinct roles for the ? , ? and ?1 isoforms of protein phosphatase 1 in the outside-in ?IIb?3 integrin signalling-dependent functions. Thromb Haemost. 2013;109:118-26 pubmed publisher
    ..Thus, PP1c isoforms have distinct contribution to the outside-in ?IIb?3 signalling-dependent functions in 293 ?IIb?3 cells. Moreover, PP1c? negatively regulates integrin function by suppressing the p38 pathway. ..
  47. Liu C, Wang R, Berndt N. Protein phosphatase 1alpha activity prevents oncogenic transformation. Mol Carcinog. 2006;45:648-56 pubmed
    Cyclin-dependent kinase 2 (Cdk2) phosphorylates Thr320 of protein phosphatase 1alpha (PP1alpha) in late G(1), thereby inhibiting its activity...
  48. Yang J, Hurley T, DePaoli Roach A. Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif. J Biol Chem. 2000;275:22635-44 pubmed
    Inhibitor-2 (I-2) is the regulatory subunit of a cytosolic type 1 Ser/Thr protein phosphatase (PP1) and potently inhibits the activity of the free catalytic subunit (CS1)...
  49. Trinkle Mulcahy L, Sleeman J, Lamond A. Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. J Cell Sci. 2001;114:4219-28 pubmed
    ..b>PP1alpha and PP1gamma fluorescent protein fusions show largely complimentary localization patterns, particularly within ..
  50. Marsh J, Dancheck B, Ragusa M, Allaire M, Forman Kay J, Peti W. Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators. Structure. 2010;18:1094-103 pubmed publisher
    ..disordered proteins: I-2, spinophilin, and DARPP-32, which bind to and regulate protein phosphatase 1 (PP1)...
  51. Ragusa M, Allaire M, Nairn A, Page R, Peti W. Flexibility in the PP1:spinophilin holoenzyme. FEBS Lett. 2011;585:36-40 pubmed publisher
    Protein phosphatase 1 (PP1) interacts with ?200 regulatory proteins to form holoenzymes, which target PP1 to specific locations and regulate its specificity...
  52. Carr A, Schmidt A, Suzuki Y, Del Monte F, Sato Y, Lanner C, et al. Type 1 phosphatase, a negative regulator of cardiac function. Mol Cell Biol. 2002;22:4124-35 pubmed
    Increases in type 1 phosphatase (PP1) activity have been observed in end stage human heart failure, but the role of this enzyme in cardiac function is unknown...
  53. Shao J, Diamond M. Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137. PLoS ONE. 2012;7:e32802 pubmed publisher
    ..increased pS137-PFN1 levels at concentrations more consistent with their known IC(50)s for protein phosphatase 1 (PP1) than protein phosphatase 2A (PP2A)...
  54. Nekhai S, Jerebtsova M, Jackson A, Southerland W. Regulation of HIV-1 transcription by protein phosphatase 1. Curr HIV Res. 2007;5:3-9 pubmed
    ..Our recent studies identified protein phosphatase-1 (PP1) as an important regulator of HIV-1 transcription...
  55. Schumann M, Gunzel D, Buergel N, Richter J, Troeger H, May C, et al. Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease. Gut. 2012;61:220-8 pubmed publisher
    ..Changes in cell polarity proteins Par-3 and PP-1 are associated with altered expression and assembly of TJ proteins claudin-2, -3, -5 and -7 and ZO-1, causing paracellular leakage in active coeliac disease. ..
  56. Ammosova T, Platonov M, Yedavalli V, Obukhov Y, Gordeuk V, Jeang K, et al. Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1. PLoS ONE. 2012;7:e39481 pubmed publisher
    ..An interaction with host Ser/Thr protein phosphatase-1 (PP1) is critical for this function of Tat...
  57. Wang L, Yang Y, Gong X, Huang Z, Nie Q, Wang Z, et al. Regulation of Eye Development by Protein Serine/Threonine Phosphatases-1 and -2A. Curr Mol Med. 2015;15:944-51 pubmed
    ..Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects. ..
  58. Shrestha C, Tang Y, Fan H, Li L, Zeng Q, Pennypacker S, et al. Phosphoprotein Phosphatase 1 Is Required for Extracellular Calcium-Induced Keratinocyte Differentiation. Biomed Res Int. 2016;2016:3062765 pubmed publisher
    ..b>PP1 knockdown blocked extracellular calcium-induced increase in serine dephosphorylation and activity of PIP5K1? and ..
  59. Minami S, Matsumoto K, Nagashio R, Hagiuda D, Fukuda E, Goshima N, et al. Analysis of Autoantibodies Related to Tumor Progression in Sera from Patients with High-grade Non-muscle-invasive Bladder Cancer. Anticancer Res. 2017;37:6705-6714 pubmed
    ..The immunoreactions for PPP1CA protein in BC was significantly correlated with pathological stage, grade, and lymphovascular invasion. PPP1CA is a candidate sero-diagnostic and prognostic marker for patients with BC. ..
  60. Connor J, Weiser D, Li S, Hallenbeck J, Shenolikar S. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Mol Cell Biol. 2001;21:6841-50 pubmed publisher
    ..inhibitor 1 (I-1), a protein kinase A (PKA)-activated inhibitor of type 1 protein serine/threonine phosphatase (PP1), in a yeast two-hybrid screen of a human brain cDNA library...
  61. Li H, Liu H, Wang C, Zhang J, Man J, Gao Y, et al. Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1. Nat Immunol. 2008;9:533-41 pubmed publisher
    ..Notably, CUEDC2 also interacted with GADD34, a regulatory subunit of protein phosphatase 1 (PP1)...
  62. Leone V, Mansueto G, Pierantoni G, Tornincasa M, Merolla F, Cerrato A, et al. CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1. Oncogene. 2010;29:4341-51 pubmed publisher
    ..Therefore, the repression of CREB1 activity by CCDC6 has a critical function in the development of human thyroid papillary carcinomas carrying RET/PTC1 activation. ..
  63. Ferrer I, Verdugo Sivianes E, Castilla M, Melendez R, Marin J, Muñoz Galvan S, et al. Loss of the tumor suppressor spinophilin (PPP1R9B) increases the cancer stem cell population in breast tumors. Oncogene. 2016;35:2777-88 pubmed publisher
    ..mimicked the cancer stem-like cell phenotype of Spn downregulation, suggesting that the mechanism of Spn involves PP1a. These increased cancer stem cell-like properties with reduced Spn might account for the malignant phenotype ..
  64. Kim W, Youn H, Kang C, Youn B. Inflammation-induced radioresistance is mediated by ROS-dependent inactivation of protein phosphatase 1 in non-small cell lung cancer cells. Apoptosis. 2015;20:1242-52 pubmed publisher
    ..Increased ROS generation negatively affected the activity of protein phosphatase 1 (PP1)...
  65. Saadat M, Mizuno Y, Kikuchi K, Yoshida M. Comparative mapping of the gene encoding the catalytic subunit of protein phosphatase type 1 alpha (PPP1CA) to human, rat, and mouse chromosomes. Cytogenet Cell Genet. 1995;70:55-7 pubmed
    ..These results suggest that PPP1CA is a member of a syntenic group. ..
  66. Ajuh P, Browne G, Hawkes N, Cohen P, Roberts S, Lamond A. Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex. Nucleic Acids Res. 2000;28:678-86 pubmed
    We have screened a human cDNA expression library with a digoxygenin-labelled protein phosphatase 1 (PP1) probe to identify novel PP1 interacting proteins...
  67. Srivastava J, Goris J, Dilworth S, Parker P. Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides. FEBS Lett. 2002;516:265-9 pubmed
    The protein phosphatases PP1(c), PP2A(c) and PP2Calpha are shown to dephosphorylate protein kinase Cdelta (PKCdelta) in vitro; of these PP2A(c) displayed the highest specific activity towards PKCdelta...
  68. Reeder J, Sowden M, Messing E, Klover P, Villa Moruzzi E, Ludlow J. Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line. Cancer Cell Int. 2003;3:12 pubmed
    ..a cell line for inducing protein expression of the type 1, alpha-isotype, serine/threonine protein phosphatase (PP1alpha)...
  69. Wobst H, Forster S, Laurini C, Sekulla A, Dreiseidler M, Hohfeld J, et al. UCHL1 regulates ubiquitination and recycling of the neural cell adhesion molecule NCAM. FEBS J. 2012;279:4398-409 pubmed publisher
    ..These data indicate that UCHL1 is a novel interaction partner of both NCAM isoforms that regulates their ubiquitination and intracellular trafficking. ..
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    ..By ribonucleic acid interference screening using a phosphorylation biosensor, we identified two PP1-targeting subunits, Sds22 and Repo-Man, which counteracted Aurora B-dependent phosphorylation of the outer ..
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    ..In this study, we observed that phosphorylation of protein phosphatase 1 (PP1) on Thr(320) is reduced in brain extracts from Egr-1(-/-) mice, indicating that a kinase downstream of Egr-1 ..
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    ..Serine/threonine protein phosphatase type-1 (PP1), a major phosphatase in the heart, consists of a catalytic subunit (PP1c) and a large set of regulatory (R)-..
  73. Mitsuhashi S, Shima H, Li Y, Tanuma N, Okamoto T, Kikuchi K, et al. Tautomycetin suppresses the TNFalpha/NF-kappaB pathway via inhibition of IKK activation. Int J Oncol. 2008;33:1027-35 pubmed
    ..Co-immunoprecipitation experiments revealed that the catalytic subunit of PP1 (PP1C) was involved in the IKK complex...
  74. Kakiya N, Saito T, Nilsson P, Matsuba Y, Tsubuki S, Takei N, et al. Cell surface expression of the major amyloid-? peptide (A?)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1. J Biol Chem. 2012;287:29362-72 pubmed publisher
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    Protein phosphatase type 1 (PP1) is involved in the regulation of numerous cell functions in mammalian cells...
  76. Kim K, Li L, Kozlowski K, Suh H, Cao W, Ballermann B. The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1 phosphorylation. Biochem Biophys Res Commun. 2005;338:1327-34 pubmed
    ..Hence, TIMAP targets PP-1 to LAMR1, and LAMR1 is a TIMAP-dependent PP-1 substrate. ..
  77. Ayllon V, Cayla X, Garcia A, Roncal F, Fernandez R, Albar J, et al. Bcl-2 targets protein phosphatase 1 alpha to Bad. J Immunol. 2001;166:7345-52 pubmed
    ..We recently have described that PP1alpha is a Ras-activated Bad phosphatase that regulates IL-2 deprivation-induced apoptosis...
  78. Marx S, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell. 2000;101:365-76 pubmed
    ..6, PKA, the protein phosphatases PP1 and PP2A, and an anchoring protein, mAKAP...
  79. Ayllon V, Martinez A C, Garcia A, Cayla X, Rebollo A. Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis. EMBO J. 2000;19:2237-46 pubmed
    ..proteins and co-immunoprecipitation techniques, we found that Bad interacts with protein phosphatase 1alpha (PP1alpha)...
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    Host cell protein phosphatase-1 (PP1) is an important regulator of human immunodeficiency virus-1 (HIV-1) transcription...
  81. Wang H, Brautigan D. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. J Biol Chem. 2002;277:49605-12 pubmed
    ..Inh2 associated with KPI-2 C-terminal domain with and without PP1C. Thus, KPI-2 is a kinase with sites to associate with PP1C and Inh2 to form a regulatory complex that is localized to membranes. ..
  82. Knockleby J, Kim B, Mehta A, Lee H. Cdk1-mediated phosphorylation of Cdc7 suppresses DNA re-replication. Cell Cycle. 2016;15:1494-505 pubmed publisher
    ..As cells exit mitosis, PP1? associates with and dephosphorylates Cdc7...
  83. Song Q, Khanna K, Lu H, Lavin M. Cloning and characterization of a human protein phosphatase 1-encoding cDNA. Gene. 1993;129:291-5 pubmed
    While sequence information is available for a number of eukaryotic protein phosphatase 1 (PP1)-encoding genes, the cloning and characterization of a complete human pp1 gene has not been reported...
  84. Yadav V, Gao X, Willard B, Hatzoglou M, Banerjee R, Kabil O. Hydrogen sulfide modulates eukaryotic translation initiation factor 2? (eIF2?) phosphorylation status in the integrated stress-response pathway. J Biol Chem. 2017;292:13143-13153 pubmed publisher
    ..Although a transient increase in endogenous H2S production provides cytoprotection, its chronic increase such as in cystathionine ?-synthase deficiency may pose a problem. ..