pp GalNAc T10

Summary

Gene Symbol: pp GalNAc T10
Description: polypeptide N-acetylgalactosaminyltransferase 10
Alias: GALNACT10, PPGALNACT10, PPGANTASE10, polypeptide N-acetylgalactosaminyltransferase 10, GalNAc transferase 10, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
Species: human
Products:     pp GalNAc T10

Top Publications

  1. Cheng L, Tachibana K, Zhang Y, Guo J, Kahori Tachibana K, Kameyama A, et al. Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10. FEBS Lett. 2002;531:115-21 pubmed
    ..In a polypeptide GalNAc-transfer assay, recombinant pp-GalNAc-T10 transferred GalNAc onto a panel of mucin-derived peptide substrates. Furthermore, pp-GalNAc-T10 demonstrated strong transferase activity with glycopeptide substrates. ..
  2. Ng M, Hester J, Wing M, Li J, Xu J, Hicks P, et al. Genome-wide association of BMI in African Americans. Obesity (Silver Spring). 2012;20:622-7 pubmed publisher
    ..Further replication and meta-analysis in African Americans and other populations will shed light on the role of these loci in different ethnic populations. ..
  3. Zhang Q, Burdette J, Wang J. Integrative network analysis of TCGA data for ovarian cancer. BMC Syst Biol. 2014;8:1338 pubmed publisher
    ..The constructed Bayesian network has identified some new genetic/epigenetic pathways, which may shed new light into the molecular mechanisms of ovarian cancer. ..
  4. Gao K, Zhang Y, Zhang L, Kong W, Xie H, Wang J, et al. Large De Novo Microdeletion in Epilepsy with Intellectual and Developmental Disabilities, with a Systems Biology Analysis. Adv Neurobiol. 2018;21:247-266 pubmed publisher
    ..These findings strongly indicate that some large de novo rare microdeletion is an important pathological cause of epilepsy with ID/DD. Our study also found a gene motif "BGNADP" should be a key small network in epilepsy with ID/DD. ..
  5. Ahmad S, Zhao W, Renström F, Rasheed A, Samuel M, Zaidi M, et al. Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study. BMC Med Genet. 2015;16:114 pubmed publisher
    ..043) with smoking on BMI. Most BMI-associated loci have directionally consistent effects on BMI in Pakistanis and Europeans. There were suggestive interactions of established BMI-related SNPs with smoking or physical activity. ..
  6. Raman J, Fritz T, Gerken T, Jamison O, Live D, Liu M, et al. The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection. J Biol Chem. 2008;283:22942-51 pubmed publisher
    ..Local sequence recognition by the catalytic domain differs between hT2 and hT10 in that hT10 requires a pre-existing GalNAc residue while hT2 does not. ..
  7. Perrine C, Ganguli A, Wu P, Bertozzi C, Fritz T, Raman J, et al. Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2. J Biol Chem. 2009;284:20387-97 pubmed publisher
    ..Our results reveal that these transferases have unique peptide and glycopeptide preferences demonstrating their substrate diversity and their likely roles ranging from initiating transferases to filling-in transferases. ..
  8. Wu Q, Liu H, Liu Y, Liu W, Pan D, Zhang W, et al. Decreased expression of hepatocyte nuclear factor 4α (Hnf4α)/microRNA-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity. J Biol Chem. 2015;290:1170-85 pubmed publisher
    ..In summary, our results reveal a novel Hnf4α/miR-122/GALNT10 regulatory pathway that facilitates EGF miR-122 activation and hepatoma growth in HBV-associated hepatocarcinogenesis. ..
  9. Dong C, Della Morte D, Beecham A, Wang L, Cabral D, Blanton S, et al. Genetic variants in LEKR1 and GALNT10 modulate sex-difference in carotid intima-media thickness: a genome-wide interaction study. Atherosclerosis. 2015;240:462-7 pubmed publisher
    ..Given the consistent findings across different-ethnic groups, further studies are warranted to perform investigations of functional genetic variants in these regions. ..

More Information

Publications13

  1. Liu L, Xiong Y, Xi W, Wang J, Qu Y, Lin Z, et al. Prognostic role of N-Acetylgalactosaminyltransferase 10 in metastatic renal cell carcinoma. Oncotarget. 2017;8:14995-15003 pubmed publisher
    ..A total of 111 valid cases were finally applied for analyses. These findings suggest that GALNT10 could be applied as a prognostic marker for OS in mRCC patients. ..
  2. Monda K, Chen G, Taylor K, Palmer C, Edwards T, Lange L, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013;45:690-6 pubmed publisher
    ..7 × 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations. ..
  3. Wu Q, Yang L, Liu H, Zhang W, Le X, Xu J. Elevated Expression of N-Acetylgalactosaminyltransferase 10 Predicts Poor Survival and Early Recurrence of Patients with Clear-Cell Renal Cell Carcinoma. Ann Surg Oncol. 2015;22:2446-53 pubmed publisher
    ..GALNT10 expression is a potential independent adverse prognostic biomarker for recurrence and survival of patients with ccRCC after nephrectomy. ..
  4. Lin X, Gu Y, Kapoor A, Wei F, Aziz T, Ojo D, et al. Overexpression of MUC1 and Genomic Alterations in Its Network Associate with Prostate Cancer Progression. Neoplasia. 2017;19:857-867 pubmed publisher
    ..0458) and DFS (P=.0163) in melanoma patients (n=367). MUC1 upregulation is associated with CRPC and bone metastasis. A nine-gene signature derived from a MUC1 network predicts PC recurrence. ..