POU4F1

Summary

Gene Symbol: POU4F1
Description: POU class 4 homeobox 1
Alias: BRN3A, Oct-T1, RDC-1, brn-3A, POU domain, class 4, transcription factor 1, brain-3A, brain-specific homeobox/POU domain protein 3A, homeobox/POU domain protein RDC-1
Species: human

Top Publications

  1. ncbi Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways
    Lely A Quina
    Department of Psychiatry, University of California, San Diego, Veterans Affairs San Diego Healthcare System, La Jolla, California 92093 0603, USA
    J Neurosci 25:11595-604. 2005
  2. ncbi The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1
    Duncan M Gascoyne
    Medical Molecular Biology Unit, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK
    Oncogene 23:3830-40. 2004
  3. ncbi Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a
    May Trieu
    Department of Psychiatry, University of California, San Diego and San Diego VA Medical Center, La Jolla, CA 92093 0603, USA
    Development 130:111-21. 2003
  4. ncbi Neural network and "ganglion" formations in vitro: a video microscopy and scanning electron microscopy study on adult cultured spiral ganglion cells
    Marja Bostrom
    Department of Otolaryngology, Uppsala University Hospital, Uppsala University, Uppsala, Sweden
    Otol Neurotol 28:1109-19. 2007
  5. ncbi Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration
    Manuel Salinas-Navarro
    Departamento de Oftalmologia, Facultad de Medicina, Campus Universitario de Espinardo, Universidad de Murcia, 30100 Espinardo, Murcia, Spain
    Exp Eye Res 90:168-83. 2010
  6. ncbi Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas
    Francisco M Nadal-Nicolás
    Departamento de Oftalmologia, Facultad de Medicina, Universidad de Murcia, Murcia, Spain
    Invest Ophthalmol Vis Sci 50:3860-8. 2009
  7. ncbi Organization of the human embryonic ventral mesencephalon
    Jenny Nelander
    Department of Experimental Medical Science and Lund Strategic Center for Stem Cell, Biology and Cell Therapy, Lund University, Sweden
    Gene Expr Patterns 9:555-61. 2009
  8. ncbi The role of endogenous lung neuropeptides in regulation of the pulmonary circulation
    I M Keith
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA
    Physiol Res 49:519-37. 2000
  9. ncbi Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons
    E J Huang
    Program in Neuroscience, Department of Physiology, and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Development 128:2421-32. 2001
  10. ncbi Expression of calcitonin gene-related peptide type 1 receptor mRNA and their activity-modifying proteins in the rat nucleus accumbens
    Ning Li
    Department of Physiology, Weifang Medical College, Weifang 261042, Shandong Province, People s Republic of China
    Neurosci Lett 362:146-9. 2004

Research Grants

  1. TRANSCRIPTION FACTORS IN CONTROL OF BRAIN DEVELOPMENT
    Eric E Turner; Fiscal Year: 2010
  2. TRANSCRIPTION FACTORS IN CONTROL OF BRAIN DEVELOPMENT
    Eric Turner; Fiscal Year: 2007
  3. Genes regulating neurogenesis in the trigeminal placode
    Michael R Stark; Fiscal Year: 2010
  4. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    Clifford J Woolf; Fiscal Year: 2010
  5. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2009
  6. Developmental pathways in the nervous system
    Eric Turner; Fiscal Year: 2007
  7. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2007
  8. Developmental pathways in the nervous system
    Eric E Turner; Fiscal Year: 2010
  9. Roles of Homeodomain Factors in Neural Development
    Mengqing Xiang; Fiscal Year: 2004
  10. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications99

  1. ncbi Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways
    Lely A Quina
    Department of Psychiatry, University of California, San Diego, Veterans Affairs San Diego Healthcare System, La Jolla, California 92093 0603, USA
    J Neurosci 25:11595-604. 2005
    ..tau/beta-galactosidase, to examine target innervation by retinal ganglion cells expressing the POU-domain factor Brn3a. Brn3a is expressed in RGCs innervating the principal retinothalamic/retinocollicular pathway mediating cortical ..
  2. ncbi The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1
    Duncan M Gascoyne
    Medical Molecular Biology Unit, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK
    Oncogene 23:3830-40. 2004
    ..These data demonstrate that oncogenic rearrangement of EWS to produce EWS/Fli-1 may enhance the antiapoptotic effect of Brn-3a and inhibit its ability to promote neuronal differentiation...
  3. ncbi Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a
    May Trieu
    Department of Psychiatry, University of California, San Diego and San Diego VA Medical Center, La Jolla, CA 92093 0603, USA
    Development 130:111-21. 2003
    b>Brn3a is a POU-domain transcription factor expressed in peripheral sensory neurons and in specific interneurons of the caudal CNS...
  4. ncbi Neural network and "ganglion" formations in vitro: a video microscopy and scanning electron microscopy study on adult cultured spiral ganglion cells
    Marja Bostrom
    Department of Otolaryngology, Uppsala University Hospital, Uppsala University, Uppsala, Sweden
    Otol Neurotol 28:1109-19. 2007
    ..To analyze if adult-dissociated spiral ganglion cells may be propagated in vitro for later use in transplantation models to form integrated neural networks...
  5. ncbi Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration
    Manuel Salinas-Navarro
    Departamento de Oftalmologia, Facultad de Medicina, Campus Universitario de Espinardo, Universidad de Murcia, 30100 Espinardo, Murcia, Spain
    Exp Eye Res 90:168-83. 2010
    ..Surviving RGCs were identified with FG applied 1 wk pre-LP or by Brn3a immunodetection. The ON and retinal nerve fiber layer were examined by RT97-neurofibrillar staining...
  6. ncbi Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas
    Francisco M Nadal-Nicolás
    Departamento de Oftalmologia, Facultad de Medicina, Universidad de Murcia, Murcia, Spain
    Invest Ophthalmol Vis Sci 50:3860-8. 2009
    To characterize Brn3a expression in adult albino rat retinal ganglion cells (RGCs) in naïve animals and in animals subjected to complete intraorbital optic nerve transection (IONT) or crush (IONC).
  7. ncbi Organization of the human embryonic ventral mesencephalon
    Jenny Nelander
    Department of Experimental Medical Science and Lund Strategic Center for Stem Cell, Biology and Cell Therapy, Lund University, Sweden
    Gene Expr Patterns 9:555-61. 2009
    ..The post-mitotic DA neurons express TH as well as NURR1 and PITX3. ISL1 and BRN3A can be used to detect the cells of OM and RN, respectively...
  8. ncbi The role of endogenous lung neuropeptides in regulation of the pulmonary circulation
    I M Keith
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA
    Physiol Res 49:519-37. 2000
    ..For example, blocking of the ET-1 receptor ET(A) and vasodilation by supplemental CGRP delivered i. v. or via airway gene transfer, have proven to be useful experimentally...
  9. ncbi Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons
    E J Huang
    Program in Neuroscience, Department of Physiology, and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Development 128:2421-32. 2001
    The POU domain transcription factors Brn3a, Brn3b and Brn3c are required for the proper development of sensory ganglia, retinal ganglion cells, and inner ear hair cells, respectively...
  10. ncbi Expression of calcitonin gene-related peptide type 1 receptor mRNA and their activity-modifying proteins in the rat nucleus accumbens
    Ning Li
    Department of Physiology, Weifang Medical College, Weifang 261042, Shandong Province, People s Republic of China
    Neurosci Lett 362:146-9. 2004
    ..In contrast, no expression was detected for RDC-1 and RAMP3. These findings indicated a functional role for CGRP and its receptors in inflammation and pain modulation...
  11. ncbi Unaltered expression of Bcl-2 and TAG-1/axonin-1 precedes sensory apoptosis in Brn3a knockout mice
    S Raisa Eng
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0603, USA
    Neuroreport 14:173-6. 2003
    Mice lacking the POU-domain transcription factor Brn3a exhibit growth defects in trigeminal axons, undergo extensive sensory cell death in late gestation, and die at birth...
  12. ncbi POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature
    J M Fortier
    Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, MO 63110, USA
    Leukemia 24:950-7. 2010
    ..Dysregulation of the Pit/Oct/Unc (POU) domain-containing transcription factor POU4F1 is a recurring abnormality in t(8;21) AML...
  13. ncbi Novel Brn3a cis-acting sequences mediate transcription of human trkA in neurons
    Ximena Valderrama
    Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Neurochem 105:425-35. 2008
    ..While the regulation of the expression of trkA is a complex process, the transcription factor Brn3a is known to play an important role as an enhancer of trkA transcription during development in the mouse...
  14. ncbi Regulation of the development of tectal neurons and their projections by transcription factors Brn3a and Pax7
    Natalia Fedtsova
    Department of Psychiatry, University of California, San Diego, CA 92093 0603, USA
    Dev Biol 316:6-20. 2008
    ..In mice expressing betagalactosidase targeted to the Pou4f1 (Brn3a) locus, Brn3a-expressing neurons contribute to the ipsilateral but not the contralateral tectofugal ..
  15. ncbi Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells
    Tudor C Badea
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 61:852-64. 2009
    ..Here we dissect the roles of the highly homologous POU-domain transcription factors Brn3a and Brn3b in retinal ganglion cell (RGC) development and function using conditional Brn3a and Brn3b alleles that ..
  16. ncbi Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription
    C D Hudson
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK
    Cell Death Differ 15:1266-78. 2008
    The Brn-3a/POU4F1 POU transcription factor is critical for the survival and differentiation of specific sensory neurons during development or upon injury; by regulating expression of target genes, either directly or indirectly upon ..
  17. ncbi mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung
    X Qing
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Am J Physiol Lung Cell Mol Physiol 280:L547-54. 2001
    ..Our results show upregulation of RDC-1, RAMP1, and RAMP3 mRNAs in hypoxic rat lung and no change in CRLR and RAMP2 mRNAs. These findings support a functional role for CGRP and ADM receptors in regulating the adult pulmonary circulation...
  18. ncbi GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear
    Grace Lawoko-Kerali
    Department of Biomedical Sciences, Institute of Molecular Physiology, Addison Building, Western Bank, Sheffield S10 2TN, UK
    Mech Dev 121:287-99. 2004
    ..line, US/VOT-33, expressed GATA3, the bHLH transcription factor NeuroD and the POU-domain transcription factor Brn3a, as do auditory neuroblasts in vivo...
  19. ncbi Identification of an N-terminal transcriptional activation domain within Brn3b/POU4f2
    Suzanna E Martin
    Department of Biochemistry and Molecular Biology, Unit 117, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Differentiation 73:18-27. 2005
    ..transcription more than 25-fold, and similar activation was observed with the closely related factor Brn3a/POU4f1. No transactivation activity was associated with the C-terminal POU domain-containing portion of Brn3b...
  20. ncbi Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes-diencephalic basal plate
    Juan Antonio Moreno-Bravo
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Cientificas, and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Dev Dyn 239:2094-101. 2010
    ..The aim of this study is to thoroughly analyze the expression pattern of Nkx6.1, Nkx6.2, and Pou4f1. These three genes are candidates to play an important role in the determination and differentiation of the basal ..
  21. ncbi Key basic helix-loop-helix transcription factor genes Hes1 and Ngn2 are regulated by Pax3 during mouse embryonic development
    Hiromichi Nakazaki
    Laboratory for Neural Tube Research, Developmental Biology Program, Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
    Dev Biol 316:510-23. 2008
    ..Pax3, as in Splotch embryos, the neural crest cells undergo premature neurogenesis, as evidenced by increased Brn3a positive staining in neural tube explants, in comparison with wild-type...
  22. ncbi Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retina
    Diego García-Ayuso
    Laboratorio de Oftalmologia Experimental, Facultad de Medicina, Universidad de Murcia, Campus de Espinardo, 30100 Espinardo, Murcia, Spain
    Exp Eye Res 91:800-10. 2010
    ..Quantification of the total number of RGCs identified by Fluorogold tracing and Brn3a expression, disclosed that the population of RGCs in young P23H rats is significantly smaller than in its ..
  23. ncbi Mechanism for the induction of cell death in ONS-76 medulloblastoma cells by Zhangfei/CREB-ZF
    Timothy W Bodnarchuk
    Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, S7N 5B4, Canada
    J Neurooncol 109:485-501. 2012
    ..In addition, we found that the transcription factor Brn3a as well as factors implicated in differentiation were also active in Zhangfei-expressing cells...
  24. ncbi Cellular localization of P2Y₆ receptor in rat retina
    P P Zhang
    Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, 138 Yixueyuan Road, Shanghai 200032, PR China
    Neuroscience 220:62-9. 2012
    ..Moreover, P2Y(6) immunoreactivity was seen in almost all ganglion cells, labeled by Brn3a. In Müller glial cells, stained by cellular retinaldehyde binding protein (CRALBP), however, no P2Y(6) expression ..
  25. ncbi Targeted knockdown of Cerkl, a retinal dystrophy gene, causes mild affectation of the retinal ganglion cell layer
    Alejandro Garanto
    Departament de Genetica, Facultat de Biologia, Spain
    Biochim Biophys Acta 1822:1258-69. 2012
    ..perturbation (from birth up to 12 months of age) of ganglion cells was supported by the decrease of the Brn3a marker expression as well as the reduced oscillatory potentials in the electroretinographic recordings...
  26. ncbi Whole number, distribution and co-expression of brn3 transcription factors in retinal ganglion cells of adult albino and pigmented rats
    Francisco M Nadal-Nicolás
    Unidad de Investigacion, Hospital Universitario Virgen de la Arrixaca Fundación para la Formación e Investigación Sanitarias de la Región de Murcia, IMIB, El Palmar, Murcia, Spain
    PLoS ONE 7:e49830. 2012
    The three members of the Pou4f family of transcription factors: Pou4f1, Pou4f2, Pou4f3 (Brn3a, Brn3b and Brn3c, respectively) play, during development, essential roles in the differentiation and survival of sensory neurons...
  27. ncbi Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrol
    Chuanzhou Li
    College of Life Sciences, Wuhan University, Wuhan, China
    Invest Ophthalmol Vis Sci 53:3241-9. 2012
    ..We investigated the possible role of ER stress in retinal vascular degeneration in vivo, and the effects of resveratrol on tunicamycin and ischemia and reperfusion (I/R)-induced retinal vascular degeneration...
  28. ncbi Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord
    Min Zou
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Dev Biol 364:114-27. 2012
    ..Given the expression of the POU homeodomain transcription factors Brn3a/Pou4f1 and Brn3b/Pou4f2 in DRG and spinal cord sensory neurons, we determined the subtype specification of DRG and spinal ..
  29. ncbi High pressure-induced retinal ischaemia reperfusion causes upregulation of gap junction protein connexin43 prior to retinal ganglion cell loss
    Nathan M Kerr
    Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    Exp Neurol 234:144-52. 2012
    ..astrocytes), glutamine synthetase (Muller cells), Isolectin B4 (vascular endothelium), DAPI (nuclear marker), and BRN3a (retinal ganglion cells). Retinal whole mounts were used to count retinal ganglion cells...
  30. ncbi Icariin ameliorates streptozotocin-induced diabetic retinopathy in vitro and in vivo
    Hua Xin
    Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China E mail
    Int J Mol Sci 13:866-78. 2012
    ..RECA), collagen IV (Col-IV), vascular endothelial growth factor (VEGF), and neuropathic changes (Thy-1 and Brn3a expression) of the retinal ganglion cells (RGCs) were investigated...
  31. ncbi Cell-autonomous FGF signaling regulates anteroposterior patterning and neuronal differentiation in the mesodiencephalic dopaminergic progenitor domain
    Laura Lahti
    Department of Biosciences, Division of Genetics, University of Helsinki, Helsinki, Finland
    Development 139:894-905. 2012
    ..Furthermore, the diencephalic DA domain forms a distinct cell population, which also contains non-DA Pou4f1(+) cells...
  32. ncbi Characterization of Progenitor Cells during Canine Retinal Development
    Mallely Avila-García
    Departamento de Biologia Celular y Fisiologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Apartado Postal 70228, Ciudad de Mexico, DF 04510, Mexico
    Stem Cells Int 2012:675805. 2012
    ..Antibodies to detected progenitor cells (Pax6, C-kit, and nestin) and ganglion cells (BDNF, Brn3a, and Thy1) were used in combination with H3 for the purpose of identifying proliferating cells...
  33. ncbi Effects of bone morphogenetic protein 2 on Id expression and neuroblastoma cell differentiation
    Yang Du
    Department of Anatomy, The University of Hong Kong, SAR, China
    Differentiation 79:84-92. 2010
    ..the expression of Id1-3 proteins and upregulating the expression of neural-specific transcriptional factors Dlx2, Brn3a, and NeuroD6...
  34. ncbi Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion
    Jason Lanier
    Department of Psychiatry and University of California, San Diego, California 92093 0603, USA
    Dev Dyn 238:3065-79. 2009
    The POU-domain transcription factor Brn3a is expressed in developing sensory neurons at all levels of the neural axis, including the trigeminal ganglion, hindbrain sensory ganglia, and dorsal root ganglia...
  35. ncbi Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development
    Lely A Quina
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0603, USA
    J Neurosci 29:14309-22. 2009
    ..Neurons of the medial habenula and part of the lateral habenula express the transcription factor Brn3a/Pou4f1, and Brn3a-expressing habenular neurons project exclusively to the interpeduncular nucleus in the ventral midbrain...
  36. ncbi Does elevated intraocular pressure reduce retinal TRKB-mediated survival signaling in experimental glaucoma?
    Ying Guo
    The Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA
    Exp Eye Res 89:921-33. 2009
    ..Out of three RGC-specific Brn3 proteins (Brn3a, b, and c), only Brn3a was significantly downregulated at the message level to 35 +/- 4% of fellow values with the ..
  37. ncbi Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain
    Nilima Prakash
    Helmholtz Centre Munich, German Research Centre for Environmental Health GmbH and Technical University Munich, Institute of Developmental Genetics, Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Munich Neuherberg, Germany
    Development 136:2545-55. 2009
    ..Nkx6-1 is expressed in ventral midbrain progenitors and acts as a fate determinant of the Brn3a(+) (also known as Pou4f1) red nucleus neurons...
  38. ncbi Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells
    Matthew M Harper
    Iowa State University, Ames, IA 50011, USA
    Exp Eye Res 89:538-48. 2009
    ..neuronal-like morphologies, and a significant increase in the proportion of RGC-5s immunoreactive for TuJ-1 and Brn3a was observed...
  39. ncbi Neural tube derived Wnt signals cooperate with FGF signaling in the formation and differentiation of the trigeminal placodes
    Claire A Canning
    Institute of Medical Biology, A STAR, 8A Biomedical Grove, 06 06 Immunos, Singapore 138648, Republic of Singapore
    Neural Dev 3:35. 2008
    ....
  40. ncbi A Thy1-CFP DBA/2J mouse line with cyan fluorescent protein expression in retinal ganglion cells
    Iona D Raymond
    Department of Neurobiology, David Geffen UCLA School of Medicine, Los Angeles, CA 90095 1763, USA
    Vis Neurosci 26:453-65. 2009
    ..Immunohistochemistry with antibodies to ganglion cell markers NF-L, NeuN, Brn3a, and SMI32 was used to confirm CFP expression in ganglion cells...
  41. ncbi Functional and morphological effects of laser-induced ocular hypertension in retinas of adult albino Swiss mice
    Manuel Salinas-Navarro
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 15:2578-98. 2009
    ..To investigate the effects of laser photocoagulation (LP)-induced ocular hypertension (OHT) on the survival and retrograde axonal transport of retinal ganglion cells (RGC), as well as on the function of retinal layers...
  42. ncbi Efficient expression of self-complementary AAV in ganglion cells of the ex vivo primate retina
    Rajeshwari D Koilkonda
    Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, USA
    Mol Vis 15:2796-802. 2009
    ..To evaluate the efficiency of self-complementary adeno-associated virus (scAAV)-mediated gene expression of green fluorescent protein (GFP) or the allotopic human ND4 subunit of complex I in ganglion cells of the primate retina...
  43. ncbi Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis
    Tudor Constantin Badea
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 32:995-1007. 2012
    The three members of the Brn3 family of POU-domain transcription factors (Brn3a/Pou4f1, Brn3b/Pou4f2, and Brn3c/Pou4f3) are expressed in overlapping subsets of visual, auditory/vestibular, and somatosensory neurons...
  44. ncbi Differential expression of Brn3 transcription factors in intrinsically photosensitive retinal ganglion cells in mouse
    Varsha Jain
    National Brain Research Centre, Manesar Haryana 122050, India
    J Comp Neurol 520:742-55. 2012
    ..The Brn3 family of class IV POU-domain transcription factors (Brn3a, Brn3b, and Brn3c) is involved in the regulation of differentiation, dendritic stratification, and axonal ..
  45. ncbi Perinatal development of melanopsin expression in the mouse retina
    Irene González-Menéndez
    Departamento de Morfologia y Biologia Celular, Universidad de Oviedo, Oviedo, Spain
    Brain Res 1419:12-8. 2011
    ..Melanopsin expression was detected at E15 in cells that did not co-express the transcription factor Brn3a. Under light/dark (LD) cycles, the number of melanopsin-expressing cells did not change between E16 and E19, while ..
  46. ncbi Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritis
    Amena W Smith
    Departments of Neurosciences, Division of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Invest Ophthalmol Vis Sci 52:4935-41. 2011
    ....
  47. ncbi Curcumin attenuates staurosporine-mediated death of retinal ganglion cells
    Balabharathi Burugula
    Eye Research Institute, Oakland University, Rochester, Michigan 48309, USA
    Invest Ophthalmol Vis Sci 52:4263-73. 2011
    ....
  48. ncbi Inhibition of reactive gliosis attenuates excitotoxicity-mediated death of retinal ganglion cells
    Bhagyalaxmi S Ganesh
    Eye Research Institute of Oakland University, Rochester, Minnesota, United States of America
    PLoS ONE 6:e18305. 2011
    ..Loss of RGCs was determined by immunostaining of flat-mounted retinas with Brn3a antibodies...
  49. ncbi Axotomy-induced retinal ganglion cell death in adult mice: quantitative and topographic time course analyses
    C Galindo-Romero
    Laboratorio de Oftalmologia Experimental, Facultad de Medicina, Universidad de Murcia, 30100 Murcia, Spain
    Exp Eye Res 92:377-87. 2011
    ..them from their main retinorecipient area, the superior colliculi, and by their expression of BRN3A (product of Pou4f1 gene)...
  50. ncbi Role of Pax3 acetylation in the regulation of Hes1 and Neurog2
    Shunsuke Ichi
    Developmental Neurobiology Laboratory, Department of Pediatric Neurosurgery, Children s Memorial Hospital, Chicago, IL 60614, USA
    Mol Biol Cell 22:503-12. 2011
    ..5, but not at E12.5. Overexpression of SIRT1 decreased Pax3 acetylation, Neurog2 and Brn3a positive staining. Conversely, siRNA-mediated silencing of SIRT1 increased these factors...
  51. ncbi Morphologies of mouse retinal ganglion cells expressing transcription factors Brn3a, Brn3b, and Brn3c: analysis of wild type and mutant cells using genetically-directed sparse labeling
    Tudor Constantin Badea
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Vision Res 51:269-79. 2011
    ..The roles of the closely related family members, Brn3a/Pou4f1 and Brn3c/Pou4f3 in RGC development are less clear...
  52. ncbi AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia
    Jenny Dunne
    Cancer Research UK Medical Oncology Unit, Barts and the London School of Medicine and Dentistry, University of London, London, United Kingdom
    Cancer Res 70:3985-95. 2010
    ..One gene whose expression is highly correlated with the presence of the AML1/ETO fusion is POU4F1, which encodes the POU homeodomain transcription factor BRN3A...
  53. ncbi EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A
    D M Gascoyne
    Molecular Haematology and Cancer Biology Unit, University College London Institute of Child Health, London, UK
    Oncogene 29:3134-45. 2010
    ..Here we show that the neuronal marker BRN3A/POU4F1 is expressed abundantly at the protein level in primary EFT but not in rhabdomyosarcoma and neuroblastoma, and EFT ..
  54. ncbi Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation
    Iain M Dykes
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Neural Dev 5:3. 2010
    The transcription factor Brn3a, product of the pou4f1 gene, is expressed in most sensory neurons throughout embryogenesis...
  55. ncbi Analysis of retinal cell development in chick embryo by immunohistochemistry and in ovo electroporation techniques
    Sung Tae Doh
    Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, USA
    BMC Dev Biol 10:8. 2010
    ..Retinal cell development has been extensively investigated; however, the current knowledge of dynamic morphological and molecular changes is not yet complete...
  56. ncbi Automated quantification and topographical distribution of the whole population of S- and L-cones in adult albino and pigmented rats
    Arturo Ortín-Martínez
    Fundación para la Formación e Investigación Sanitarias de la Región de Murcia, Murcia, Spain
    Invest Ophthalmol Vis Sci 51:3171-83. 2010
    ..To quantify the whole population of S- and L-cones in the albino (Sprague-Dawley, SD) and pigmented (Piebald Virol Glaxo, PVG) rats and to study their topographical distribution within the retina...
  57. ncbi Proteomics, bioinformatics and targeted gene expression analysis reveals up-regulation of cochlin and identifies other potential biomarkers in the mouse model for deafness in Usher syndrome type 1F
    Mark R Chance
    Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Hum Mol Genet 19:1515-27. 2010
    ..candidates from the proteomic and bioinformatic investigations showed up-regulation of Coch mRNA and those of p53, Brn3a and Nrf2, transcription factors linked to stress response and survival...
  58. ncbi The Brn-3a transcription factor gene (POU4F1) maps close to the locus for the variant late infantile form of neuronal ceroid-lipofuscinosis
    I H Still
    Department of Neurosciences NC30, Cleveland Clinic Foundation, Ohio 44195, USA
    Cytogenet Cell Genet 74:225-6. 1996
    We have refined the location of the Brn-3a genomic locus (POU4F1), using somatic cell hybrid analysis, to 13q21.1-->q22...
  59. ncbi Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesis
    Ling Pan
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Development 132:703-12. 2005
    ..By knocking-in Brn3a (Brn3aki) into the Brn3b locus, we showed here that Brn3aki was expressed in a spatiotemporal manner identical to ..
  60. ncbi Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival
    Amanda K Wiggins
    Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 167:257-67. 2004
    The Pit1-Oct1-Unc86 domain (POU domain) transcription factor Brn3a controls sensory neuron survival by regulating the expression of Trk receptors and members of the Bcl-2 family...
  61. ncbi Regulation of Hsp27 expression and cell survival by the POU transcription factor Brn3a
    S R Farooqui-Kabir
    Cell Death Differ 11:1242-4. 2004
  62. ncbi Coordinated regulation of gene expression by Brn3a in developing sensory ganglia
    S Raisa Eng
    Department of Psychiatry, University of California, San Diego, and the VA San Diego Healthcare System, La Jolla, CA 92093 0603, USA
    Development 131:3859-70. 2004
    Mice lacking the POU-domain transcription factor Brn3a exhibit marked defects in sensory axon growth and abnormal sensory apoptosis...
  63. ncbi Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia
    Michael Sindos
    Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Gynecol Oncol 90:366-71. 2003
    ..We also analysed whether Brn-3a levels can be used in combination with Pap smear to predict the presence of cervical intraepithelial lesion...
  64. ncbi Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons
    Long Ma
    Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Development 130:3525-34. 2003
    ..The molecular mechanisms regulating tissue and stage-specific expression of TrkA are largely unknown. The Brn3a POU-domain transcription factor has been implicated in the development of the PNS and proposed as a transcription ..
  65. ncbi Development of inner ear afferent connections: forming primary neurons and connecting them to the developing sensory epithelia
    Bernd Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Brain Res Bull 60:423-33. 2003
    ..NeuroD and a later expressed gene, Brn3a, play a role in pathfinding to and within sensory epithelia...
  66. ncbi Targeted blocking of gene expression for CGRP receptors elevates pulmonary artery pressure in hypoxic rats
    Xin Qing
    Department of Comparative Biosciences, University of Wisconsin Madison, School of Veterinary Medicine, AHABS Bldg, 1656 Linden Drive, Madison, WI 53706, USA
    Am J Physiol Lung Cell Mol Physiol 285:L86-96. 2003
    ..This is the first in vivo evidence supporting RDC-1 and RAMP1 as functional CGRP receptor and receptor component...
  67. ncbi The pro-oncoprotein EWS (Ewing's Sarcoma protein) interacts with the Brn-3a POU transcription factor and inhibits its ability to activate transcription
    G Ruth Thomas
    Medical Molecular Biology Unit, Institute of Child Health, University College London, UK
    Cancer Biol Ther 1:428-32. 2002
    ..The significance of this novel interaction is discussed in terms of the manner in which Brn-3a regulates its target promoters and the mechanism of oncogenic transformation by EWS-Fli1...
  68. ncbi Gene expression of the POU factor Brn-3a is regulated by two different promoters
    Beate Frass
    Institut für Zellbiologie Tumorforschung, I F Z, Universitatsklinikum Essen, Virchowstrasse 173, Essen, Germany
    Biochim Biophys Acta 1579:207-13. 2002
    ..We propose therefore that the existence of two promoters in the Brn-3a gene offers a possibility for the observed differential and cell type-specific expression of the gene...
  69. ncbi Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth
    Steven W Wang
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 129:467-77. 2002
    ..During retinal ganglion cell differentiation, Brn3b is expressed first, followed by Brn3a and Brn3c...
  70. ncbi Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice
    S R Eng
    Department of Psychiatry and Program in Neuroscience, University of California, San Diego, USA
    J Neurosci 21:541-9. 2001
    b>Brn3a/Brn-3.0 is a POU-domain transcription factor expressed in primary sensory neurons of the cranial and dorsal root ganglia and in specific neurons in the caudal CNS...
  71. ncbi Coordinated Up-regulation by hypoxia of adrenomedullin and one of its putative receptors (RDC-1) in cells of the rat blood-brain barrier
    A Ladoux
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 275:39914-9. 2000
    ..Hypoxia selectively up-regulated expression of RDC-1 receptor mRNAs. The results indicate that ADM and RDC-1 are hypoxia-sensitive genes and that RDC-1 receptors may mediate some actions of ADM in hypoxic astrocytes...
  72. ncbi NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons
    S Wyatt
    Department of Molecular Pathology, University College London Medical School, The Windeyer Building, 46 Cleveland Street, London, WIP 6DB, UK
    Brain Res Mol Brain Res 55:254-64. 1998
    We have used a quantitative RT-PCR approach to determine the levels of Brn3a and Brn3b POU domain transcription factor mRNAs in the developing mouse trigeminal ganglion from E10 to E18...
  73. ncbi The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons
    M Xiang
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 15:4762-85. 1995
    ....
  74. ncbi Mesencephalic trigeminal nucleus development is dependent on Krox-20 expression
    Shampa De
    Center for Craniofacial Molecular Biology, School of Dentistry, Los Angeles, CA, USA
    Dev Neurosci 27:49-58. 2005
    ..gene expression or peripheral projection patterns between genotypes, as demonstrated by retrograde tracing and Brn3a immunohistochemistry...
  75. ncbi Short-term lineage analysis of dorsally derived Olig3 cells in the developing spinal cord
    Lei Ding
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5 1 Higashiyama, Myodaiji, Okazaki, 444 8787, Japan
    Dev Dyn 234:622-32. 2005
    ..Some of the dorsal Olig3 lineage cells co-expressed Islet1/2, Math1, or Brn3a, markers for dorsal interneuron. LacZ-positive cells were observed in the ventral-most part of the E10...
  76. ncbi Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a
    D Ndisang
    Medical Molecular Biology Unit, Institute of Child Health, University College London, and Department of Women s and Children s Health, The Whittington Hospital, London, UK
    Oncogene 25:51-60. 2006
    ..These results help explain why the specific interplay between viral and cellular factors necessary for the progression to cervical carcinoma only occurs in a minority of those infected with HPV-16...
  77. ncbi Differentiation of inner ear stem cells to functional sensory neurons
    Rodrigo Martinez-Monedero
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Neurobiol 68:669-84. 2008
    ..Markers of embryonic auditory and other sensory neurons, GATA3, Brn3a, and islet1, could be detected after 3 days of differentiation of the cells, and markers of the sensory phenotype, ..
  78. ncbi Sonic hedgehog regulates the position of the trigeminal ganglia
    Natalia Fedtsova
    Department of Psychiatry, University of California, San Diego and San Diego VA Medical Center, La Jolla, CA 92093 0603, USA
    Dev Biol 261:456-69. 2003
    ..Neurons within these ganglia coexpress the transcription factors Brn3a and Islet, which together characterize primary sensory neurons throughout the developing embryo...
  79. ncbi Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons
    Yi Xu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:4037-46. 2008
    ..Mutations of Tlx3 and Tlx1 result in a loss of expression of these peptide genes. Brn3a, a homeobox transcription factor, the expression of which is partly dependent on Tlx3, is required specifically ..
  80. ncbi Development and characterization of an adult retinal explant organotypic tissue culture system as an in vitro intraocular stem cell transplantation model
    Thomas V Johnson
    Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    Invest Ophthalmol Vis Sci 49:3503-12. 2008
    ..To develop and characterize a retinal explant culture system to facilitate investigation of novel methods of improving retinal stem cell therapy...
  81. ncbi PA6-induced human embryonic stem cell-derived neurospheres: a new source of human peripheral sensory neurons and neural crest cells
    Oz Pomp
    Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, 52900 Ramat Gan, Israel
    Brain Res 1230:50-60. 2008
    ..These NSPs passaged for 2-8weeks and re-plated on PA6 gave rise to many Brn3a+/peripherin+ cells, characteristic of early sensory-like neurons...
  82. ncbi Cyan fluorescent protein expression in ganglion and amacrine cells in a thy1-CFP transgenic mouse retina
    Iona D Raymond
    Department of Neurobiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    Mol Vis 14:1559-74. 2008
    ..To characterize cyan fluorescent protein (CFP) expression in the retina of the thy1-CFP (B6.Cg-Tg(Thy1-CFP)23Jrs/J) transgenic mouse line...
  83. ncbi Expression of AP-2delta in the developing chick retina
    Xiaodong Li
    Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    Dev Dyn 237:3210-21. 2008
    ..Co-immunostaining with anti-Brn3a and anti-AP-2delta antibodies indicates that approximately one-third of Brn3a-positive ganglion cells express AP-..
  84. ncbi Zhangfei, a novel regulator of the human nerve growth factor receptor, trkA
    Ximena Valderrama
    Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Neurovirol 14:425-36. 2008
    ..Because the neuronal transcription factor Brn3a, which regulates trkA expression, has a motif for binding HCF, we investigated if Zhangfei had an effect on its ..
  85. ncbi Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
    Frederic Sierro
    Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 104:14759-64. 2007
    ..Our results reveal a specialized role for CXCR7 in endothelial biology and valve development and highlight the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CXCR4...
  86. ncbi Brn3 transcription factors control terminal osteoclastogenesis
    ULRIKE SCHULZE SPATE
    Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts 02115, USA
    J Cell Biochem 102:1-12. 2007
    ..RANKL stimulation induces expression of Brn3a and b and maximal transcriptional activity of Brn3 family members concurrent with osteoclastic giant cell ..
  87. ncbi Genetic single-cell mosaic analysis implicates ephrinB2 reverse signaling in projections from the posterior tectum to the hindbrain in zebrafish
    Tomomi Sato
    Laboratory for Developmental Gene Regulation, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    J Neurosci 27:5271-9. 2007
    ..The retinotectal and the tectobulbar projections were visualized in a zebrafish stable transgenic line Tg(brn3a-hsp70:GFP)...
  88. ncbi Brn-3a neuronal transcription factor functional expression in human prostate cancer
    J K J Diss
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK
    Prostate Cancer Prostatic Dis 9:83-91. 2006
    ..7 sodium channel, concomitantly upregulated in human CaP, in an isoform-specific manner. It is concluded that targeting Brn-3a could be a useful strategy for controlling the expression of multiple genes that promote CaP...
  89. ncbi Regulation of FGF10 by POU transcription factor Brn3a in the developing trigeminal ganglion
    Eric Cox
    Department of Psychiatry, University of California, San Diego and VA San Diego Healthcare System, La Jolla, California 92093, USA
    J Neurobiol 66:1075-83. 2006
    The POU-domain transcription factor Brn3a is expressed in specific neurons of the caudal CNS and peripheral sensory nervous system...
  90. ncbi Brn3a and Klf7 cooperate to control TrkA expression in sensory neurons
    Lei Lei
    Center for Developmental Biology and Kent Waldrep Center for Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Dev Biol 300:758-69. 2006
    The zinc finger protein Klf7 and POU homeodomain protein Brn3a are each required for efficient transcription of TrkA in primary sensory neurons...
  91. ncbi Brn3a target gene recognition in embryonic sensory neurons
    Jason Lanier
    Department of Psychiatry, 0603, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Dev Biol 302:703-16. 2007
    ..with changed expression in the trigeminal ganglia of mice lacking Brn3a, a transcription factor encoded by the Pou4f1 gene...
  92. ncbi POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia
    S Raisa Eng
    Department of Psychiatry, University of California, San Diego and VA San Diego Healthcare System, Gilman Drive, La Jolla, CA 92093 0603, USA
    Neural Dev 2:3. 2007
    ..Although these ganglia have similar functions, they have distinct embryological origins, in that both contain neurons originating from the neural crest, while only the TG includes cells derived from the placodal ectoderm...
  93. ncbi A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system
    R G Collum
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY
    Nucleic Acids Res 20:4919-25. 1992
    ..Based on its unique structural characteristics and expression pattern, we discuss potential functions for the RDC-1 protein...
  94. ncbi Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor
    M Calissano
    Institute of Child Health, Medical Molecular Biology Unit, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Oncogene 22:5408-14. 2003
    ..In this work, we describe the evidence for a functional interaction between Brn-3a and Rin and demonstrate the role of Rin in modulating the activation of the Brn-3a regulated egr-1 promoter by the N-terminal domain of Brn-3a...
  95. ncbi Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality
    M Sindos
    Institute of Child Health, University College London, UK
    Int J Gynecol Cancer 13:515-7. 2003
    ..These results indicate that Brn-3a could play an important role in the near future in improving cervical cancer screening...
  96. ncbi Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor
    M D Smith
    Department of Molecular Pathology, University College London Medical School, United Kingdom
    J Biol Chem 272:1382-8. 1997
    ..Hence a single amino acid difference results in these closely related factors having opposite effects and allows the balance between them to regulate differentiation...
  97. ncbi Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs
    M R Gerrero
    Eukaryotic Regulatory Biology Program, Howard Hughes Medical Institute, University of California, San Diego
    Proc Natl Acad Sci U S A 90:10841-5. 1993
    ..Brn-3.0, Brn-3.1, and the Drosophila tI-POU share an N-terminal region of homology, referred to as the "POU-IV box," which is similar to a conserved functional domain in the c-myc gene family...
  98. ncbi Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells
    A K Bhargava
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06536 0812
    Proc Natl Acad Sci U S A 90:10260-4. 1993
    ..Transient transfection of the gene encoding Oct-T1 decreased the activity of the interleukin 2 gene promoter in activated Jurkat cells. Further, there is evidence for an additional octamer-binding protein, Oct-T3, in Jurkat T cells...
  99. ncbi POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element
    V Budhram-Mahadeo
    Department of Molecular Pathology, The Windeyer Institute of Medical Sciences, University College Medical School, London, United Kingdom
    Mol Cell Biol 18:1029-41. 1998
    ..These observations and their implications for transcriptional regulation by the ER are discussed...

Research Grants35

  1. TRANSCRIPTION FACTORS IN CONTROL OF BRAIN DEVELOPMENT
    Eric E Turner; Fiscal Year: 2010
    ..The focus of the current study is the POU-domain factor Brn3a (Brn3.0, Pou4f1), expressed in primary sensory neurons at all axial levels and in selected neurons of the retina, diencephalon, ..
  2. TRANSCRIPTION FACTORS IN CONTROL OF BRAIN DEVELOPMENT
    Eric Turner; Fiscal Year: 2007
    ..The focus of the current study is the POU-domain factor Brn3a (Brn3.0, Pou4f1), expressed in primary sensory neurons at all axial levels and in selected neurons of the retina, diencephalon, ..
  3. Genes regulating neurogenesis in the trigeminal placode
    Michael R Stark; Fiscal Year: 2010
    ..Several other genes are subsequently expressed in the trigeminal placode, including Brn3a, neurogenin-2, and other downstream neuronal markers...
  4. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    Clifford J Woolf; Fiscal Year: 2010
    ..of shRNA to DRG neurons, and of conditional ATF3 knockout limited to adult DRG neurons, using an inducible Brn3a Cre driver...
  5. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2009
    ..In contrast, homeodomain transcription factor Brn3a antagonizes p53 and promotes the expression of TrkA and Bcl-xL...
  6. Developmental pathways in the nervous system
    Eric Turner; Fiscal Year: 2007
    ..We are currently studying Brn3a, a member of the POU subclass of homeodomain transcription factors...
  7. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2007
    ..In contrast, homeodomain transcription factor Brn3a antagonizes p53 and promotes the expression of TrkA and Bcl-xL...
  8. Developmental pathways in the nervous system
    Eric E Turner; Fiscal Year: 2010
    ..In prior work using transgenic mice we have shown that the POU- homeodomain factor Brn3a is required for the proper development of sensory neurons of the trigeminal and dorsal root ganglia...
  9. Roles of Homeodomain Factors in Neural Development
    Mengqing Xiang; Fiscal Year: 2004
    ..We have demonstrated that the POU homeodomain transcription factors Brn3a and Brn3b play essential roles during sensorineural development...
  10. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2005
    ..In contrast, homeodomain transcription factor Brn3a antagonizes p53 and promotes the expression of Bcl-2 and Bcl-xL...
  11. Replacing an Animal Resource Facility Cage Washer.
    Kristen Drescher; Fiscal Year: 2007
    ....
  12. The Optic Nerve Head in Glaucoma
    Elaine Johnson; Fiscal Year: 2007
    ..abstract_text> ..