Gene Symbol: POU2AF1
Description: POU class 2 associating factor 1
Alias: BOB1, OBF-1, OBF1, OCAB, POU domain class 2-associating factor 1, B-cell-specific coactivator OBF-1, BOB-1, OCA-B, OCT-binding factor 1
Species: human
Products:     POU2AF1

Top Publications

  1. Thio C, Reznichenko A, van der Most P, Kamali Z, Vaez A, Smit J, et al. Genome-Wide Association Scan of Serum Urea in European Populations Identifies Two Novel Loci. Am J Nephrol. 2019;49:193-202 pubmed publisher
    ..6 genome-wide significant single nucleotide polymorphisms (SNPs) in or near 6 loci, of which 2 were novel (POU2AF1 and ADAMTS9-AS2). Replication of East-Asian and Scottish data provided evidence for an additional 8 loci...
  2. O Malley D, Dogan A, Fedoriw Y, Medeiros L, Ok C, Salama M. American Registry of Pathology Expert Opinions: Immunohistochemical evaluation of classic Hodgkin lymphoma. Ann Diagn Pathol. 2019;39:105-110 pubmed publisher
    ..diagnosis that includes large B-cell lymphoma or variants, additional markers recommended are: CD45, OCT2, BOB1, CD79a and MUM1/IRF4...
  3. Huang J, Wang L, Jiang M, Chen Q, Jiang Z, Feng H. AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response. Cell Immunol. 2014;290:102-6 pubmed publisher
    ..metastasis through repression with cytoskeleton of MAST1; steroid metabolism of SOAT2; humoral immune response of POU2AF1; interferon alpha-inducible of IFI6; immunoglobulin of IGKC_3, CTA_246H3.1...
  4. Wang J, New J, Xie S, Yang P, Wu Q, Li J, et al. Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice. Arthritis Rheum. 2013;65:2703-12 pubmed publisher
    ..4, B lymphocyte-induced maturation protein 1, and X-box binding protein 1 and the p-CREB target genes Fosb and Obf1, and down-regulation of the GC program genes Aid, Pax5, and Bach2 compared to BXD2 mice...
  5. Takimoto Shimomura T, Tsukamoto T, Maegawa S, Fujibayashi Y, Matsumura Kimoto Y, Mizuno Y, et al. Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2. Invest New Drugs. 2019;37:210-222 pubmed publisher
    ..pathway, such as CD19, BLNK and CD79B; and those associated with B-cell development, such as IKZF1, IKZF3, PAX5, POU2AF1 and EBF1...
  6. Chevrier S, Kratina T, Emslie D, Karnowski A, Corcoran L. Germinal center-independent, IgM-mediated autoimmunity in sanroque mice lacking Obf1. Immunol Cell Biol. 2014;92:12-9 pubmed publisher
    ..b>Obf1 is a transcriptional co-activator required for normal T-cell-dependent antibody responses, and it is essential for ..
  7. Park K, Bayles I, Szlachta McGinn A, Paul J, Boiko J, Santos P, et al. Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response. J Immunol. 2014;193:4663-74 pubmed publisher
    ..IRE1α is efficiently phosphorylated, but the amounts of Ig κ, ATF6, BiP, Cyclin B2, OcaB (BOB1, Pou2af1), and XBP1 mRNAs, unspliced and spliced, are severely reduced in ELL2-deficient cells...
  8. Carter S, Miard S, Caron A, Sallé Lefort S, St Pierre P, Anhê F, et al. Loss of OcaB Prevents Age-Induced Fat Accretion and Insulin Resistance by Altering B-Lymphocyte Transition and Promoting Energy Expenditure. Diabetes. 2018;67:1285-1296 pubmed publisher
    ..that the number of follicular B2 lymphocytes and expression of the B-cell-specific transcriptional coactivator OcaB increase with age in spleen and in intra-abdominal epididymal white adipose tissue (eWAT), concomitantly with ..
  9. Zhao Y, Yu W, Hu X, Shi Y, Liu Y, Zhong Y, et al. Physiological and transcriptomic analysis revealed the involvement of crucial factors in heat stress response of Rhododendron hainanense. Gene. 2018;660:109-119 pubmed publisher
    ..hainanense (ABR1, IAA26, OBF1, LUX, SCL3, DIV, NAC29, NAC72 and TCP3) and their potential regulations for the crosstalk between hormonal signal ..

More Information


  1. Silverblatt Buser E, Frick M, Rabeler C, Kaplinsky N. Genetic Interactions Between BOB1 and Multiple 26S Proteasome Subunits Suggest a Role for Proteostasis in Regulating Arabidopsis Development. G3 (Bethesda). 2018;8:1379-1390 pubmed publisher
    ..We investigated how BOB1, an Arabidopsis thaliana small heat shock protein, maintains normal plant development...
  2. Port M, Herodin F, Valente M, Drouet M, Lamkowski A, Majewski M, et al. First Generation Gene Expression Signature for Early Prediction of Late Occurring Hematological Acute Radiation Syndrome in Baboons. Radiat Res. 2016;186:39-54 pubmed publisher
    ..to H0 (RNASE3, DAGLA, ARG2), but other genes showed a strong 14- to 33-fold down-regulation relative to H0 (WNT3, POU2AF1, CCR7). All of these genes allowed an almost completely identifiable separation among each of the HARS categories...
  3. Yamashita K, Kawata K, Matsumiya H, Kamekura R, Jitsukawa S, Nagaya T, et al. Bob1 limits cellular frequency of T-follicular helper cells. Eur J Immunol. 2016;46:1361-70 pubmed publisher
    ..In this study, we found that Tfh cells preferentially express the transcriptional coactivator Bob1. Bob1 of Tfh cells was dispensable for the expression of B-cell lymphoma-6 and the functional property of the cells ..
  4. Szablewski V, Ingen Housz Oro S, Baia M, Delfau Larue M, Copie Bergman C, Ortonne N. Primary Cutaneous Follicle Center Lymphomas Expressing BCL2 Protein Frequently Harbor BCL2 Gene Break and May Present 1p36 Deletion: A Study of 20 Cases. Am J Surg Pathol. 2016;40:127-36 pubmed publisher
    ..at diagnosis, selected on the basis of BCL2 protein expression using 2 BCL2 antibodies (clones 124 and E17) and BOB1/BCL2 double immunostaining...
  5. Krysiak K, Gomez F, White B, Matlock M, Miller C, Trani L, et al. Recurrent somatic mutations affecting B-cell receptor signaling pathway genes in follicular lymphoma. Blood. 2017;129:473-483 pubmed publisher
    ..Notch, SWitch/sucrose nonfermentable (SWI/SNF), vacuolar ATPases) and identified novel recurrent mutations (EGR1/2, POU2AF1, BTK, ZNF608, HVCN1) that require further investigation in the context of FL biology, prognosis, and treatment.
  6. Kilzheimer M, Quandt J, Langhans J, Weihrich P, Wirth T, Brunner C. NF-κB-dependent signals control BOB.1/OBF.1 and Oct2 transcriptional activity in B cells. Eur J Immunol. 2015;45:3441-53 pubmed publisher
    ..1/OBF.1 gene. The identification of so far unknown inducers that regulate BOB.1/OBF.1 expression in B cells provides novel insights in the potential function of BOB.1/OBF.1 during different aspects of B-cell development and function. ..
  7. Pérez Arnaiz P, Kaplan D. An Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication Initiation. J Mol Biol. 2016;428:4608-4625 pubmed publisher
    ..mcm5-bob1 bypasses the growth defect conferred by DDK-phosphodead Mcm2 in budding yeast...
  8. Karnowski A, Cao C, Matthias G, Carotta S, Corcoran L, Martensson I, et al. Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1. PLoS ONE. 2008;3:e3568 pubmed publisher
    ..These studies uncover a novel role for OBF-1 and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR function. ..
  9. Stauss D, Brunner C, Berberich Siebelt F, Höpken U, Lipp M, Müller G. The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6. EMBO J. 2016;35:881-98 pubmed publisher
    ..Here, we report that the transcriptional coactivator Bob1, encoded by thePou2af1gene, promotes Bcl6 expression and Tfh cell development...
  10. Piccaluga P, Agostinelli C, Fuligni F, Righi S, Tripodo C, Re M, et al. IFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation. J Immunol Res. 2015;2015:747645 pubmed publisher
    ..expression is inversely correlated with a few master regulators of B-cell differentiation such as BCL6, XBP1, POU2AF1, and BLIMP1...
  11. Advani A, Lim K, Gibson S, Shadman M, Jin T, Copelan E, et al. OCT-2 expression and OCT-2/BOB.1 co-expression predict prognosis in patients with newly diagnosed acute myeloid leukemia. Leuk Lymphoma. 2010;51:606-12 pubmed publisher
    ..10, p = 0.036) and a trend toward a worse OS (HR 1.10, p = 0.063). OCT-2 may act as a cell survival factor in AML by mediating expression of downstream targets, such as BCL-2. These results will need to be validated prospectively. ..
  12. Pérez Arnaiz P, Bruck I, Colbert M, Kaplan D. An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-? to Mcm2-7. Nucleic Acids Res. 2017;45:7261-7275 pubmed publisher
    ..We then expressed the mcm10-4A in mcm5-bob1 mutant cells to bypass the defects mediated by diminished stimulation of DDK phosphorylation of Mcm2...
  13. Junker S, Brøndum Nielsen K, Newell J, Matthias P, Tommerup N. Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization. Genomics. 1996;33:143-5 pubmed
  14. Salas M, Eckhardt L. Critical role for the Oct-2/OCA-B partnership in Ig-secreting cells. J Immunol. 2003;171:6589-98 pubmed
    ..Our results show that OCA-B and Oct-2 are regulatory partners in this process and that PU.1 plays a subordinate role at this cell stage. ..
  15. Wong M, Henry R, Ma B, Kobayashi R, Klages N, Matthias P, et al. The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1. Mol Cell Biol. 1998;18:368-77 pubmed
    ..They also provide an example of a basal transcription factor containing a Myb DNA binding domain. ..
  16. Sauter P, Matthias P. The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene induction. Immunobiology. 1997;198:207-16 pubmed
  17. Auer R, Starczynski J, McElwaine S, Bertoni F, Newland A, Fegan C, et al. Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. Genes Chromosomes Cancer. 2005;43:1-10 pubmed
    ..The breakpoint is between genes POU2AF1 and BTG4...
  18. Zhou H, Brekman A, Zuo W, Ou X, Shaykhiev R, Agosto Perez F, et al. POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. J Immunol. 2016;196:3159-67 pubmed publisher
    ..data from normal human airway epithelium, we detected expression of POU domain class 2-associating factor 1 (POU2AF1), a known transcription cofactor previously thought to be expressed only in lymphocytes...
  19. Casellas R, Jankovic M, Meyer G, Gazumyan A, Luo Y, Roeder R, et al. OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes. Cell. 2002;110:575-85 pubmed
    b>OcaB, a transcriptional coactivator also known as Bob-1 or OBF-1, was isolated on the basis of its ability to enhance transcription of immunoglobulin (Ig) genes in vitro...
  20. Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, Kawai Y, et al. Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population. Hum Mol Genet. 2017;26:650-659 pubmed publisher
    ..487 primary biliary cholangitis [PBC] cases and 476 healthy controls) identified TNFSF15 (rs4979462) and POU2AF1 (rs4938534) as strong susceptibility loci for PBC...
  21. Ou R, Huang J, Shen H, Liu Z, Zhu Y, Zhong Q, et al. Transcriptome analysis of CD34+ cells from myelodysplastic syndrome patients. Leuk Res. 2017;62:40-50 pubmed publisher
    ..C10orf10 and CD79B were specifically changed in RA patients with del(5q), while POU2AF1 were in RARS patients with del(5q)...
  22. Siegel R, Kim U, Patke A, Yu X, Ren X, Tarakhovsky A, et al. Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development. Cell. 2006;125:761-74 pubmed
    ..Combined with the deregulation of OCA-B target genes, this may help explain the multitude of defects observed in B cell development and immune responses of Oca-b-/- mice. ..
  23. Yin L, Xu J, Li M, Reddy V, Zhou Q, Liu H, et al. Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers. Histopathology. 2016;69:775-783 pubmed publisher
    ..B cell-specific transcription factors, Oct2 and Bob1, have been shown to be expressed consistently in most, if not all, B cell lymphomas, and therefore we investigated ..
  24. Hoeller S, Zihler D, Zlobec I, Obermann E, Pileri S, Dirnhofer S, et al. BOB.1, CD79a and cyclin E are the most appropriate markers to discriminate classical Hodgkin's lymphoma from primary mediastinal large B-cell lymphoma. Histopathology. 2010;56:217-28 pubmed publisher
    ..1 (100%), CD79a (89%) and p63 (82%). The use of at least three of the most accurate immunohistochemical markers, cyclin E, CD79a and BOB.1, may be helpful in the differential diagnosis of cHL and PMBCL. ..
  25. Galiegue Zouitina S, Quief S, Hildebrand M, Denis C, Lecocq G, Collyn d Hooghe M, et al. Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation. C R Acad Sci III. 1995;318:1125-31 pubmed
    ..chimeric transcript was created by fusion, 5' to the LAZ3 exon 2, with a transcribed sequence identical to BOB1/OBF1, a B cell-specific coactivator of octamer-binding transcription factors, recently described...
  26. Ban M, Booth D, Heard R, Stewart G, Goris A, Vandenbroeck K, et al. Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans. J Neuroimmunol. 2006;179:108-16 pubmed
    ..Association mapping across the candidate genes implicated by these markers in 937 UK trio families revealed modestly associated haplotypes in JAG1 (p=0.019) on chromosome 20p12.2 and POU2AF1 (p=0.003) on chromosome 11q23.1.
  27. Bastia D, Srivastava P, Zaman S, Choudhury M, Mohanty B, Bacal J, et al. Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest. Proc Natl Acad Sci U S A. 2016;113:E3639-48 pubmed publisher
    ..Retention of Tof1 in the chromatin fraction and PFA in vivo was promoted by the suppressor mcm5-bob1, which bypassed DDK requirement, indicating that under this condition a kinase other than DDK catalyzed the ..
  28. Malone C, Wall R. Bob1 (OCA-B/OBF-1) differential transactivation of the B cell-specific B29 (Ig beta) and mb-1 (Ig alpha) promoters. J Immunol. 2002;168:3369-75 pubmed
    ..promoter is transactivated in B and non-B cells by cotransfection with the B cell-specific octamer cofactor gene, Bob1 (OCA-B/OBF-1). The expression of Bob1 is also sufficient to override the silencing effects of the B29 silencer...
  29. Herbeck R, Teodorescu Brinzeu D, Giubelan M, Lazăr E, Dema A, Ioniţă H. B-cell transcription factors Pax-5, Oct-2, BOB.1, Bcl-6, and MUM1 are useful markers for the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma. Rom J Morphol Embryol. 2011;52:69-74 pubmed
    ..Thus, although the expression of transcription factors is very heterogeneous, their simultaneous implementation for positive and differential diagnosis may be useful. ..
  30. Ren X, Siegel R, Kim U, Roeder R. Direct interactions of OCA-B and TFII-I regulate immunoglobulin heavy-chain gene transcription by facilitating enhancer-promoter communication. Mol Cell. 2011;42:342-55 pubmed publisher
    ..These and other results reveal an important function for OCA-B in Igh 3' enhancer function in vivo and strongly favor an enhancer mechanism involving looping and facilitated factor recruitment rather than a tracking mechanism. ..
  31. Tampella G, Baronio M, Vitali M, Soresina A, Badolato R, Giliani S, et al. Evaluation of CARMA1/CARD11 and Bob1 as candidate genes in common variable immunodeficiency. J Investig Allergol Clin Immunol. 2011;21:348-53 pubmed
    ..Animal models for 2 genes involved in B-cell development, namely CARMA1/CARD11 and Bob1, develop an immunological phenotype similar to that seen in CVID, with low immunoglobulin serum levels, defective ..
  32. Zwilling S, Dieckmann A, Pfisterer P, Angel P, Wirth T. Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. Science. 1997;277:221-5 pubmed
    ..Thus, BOB.1/OBF.1 is a transcriptional coactivator that is critically regulated by posttranslational modifications to mediate cell type-specific gene expression. ..
  33. Kupfer S, Anderson J, Hooker S, Skol A, Kittles R, Keku T, et al. Genetic heterogeneity in colorectal cancer associations between African and European americans. Gastroenterology. 2010;139:1677-85, 1685.e1-8 pubmed publisher
    ..35; P = .04), and altogether the odds ratios were in the opposite direction for 9 of the 22 SNPs tested. There is genetic heterogeneity in CRC associations in Americans of African versus European descent. ..
  34. Gstaiger M, Knoepfel L, Georgiev O, Schaffner W, Hovens C. A B-cell coactivator of octamer-binding transcription factors. Nature. 1995;373:360-2 pubmed
    ..Here we use a modified yeast one-hybrid assay to isolate a B-cell factor, Bob1, which associates with either Oct-2 or Oct-1...
  35. Schaffer A, Kim E, Wu X, Zan H, Testoni L, Salamon S, et al. Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements. J Biol Chem. 2003;278:23141-50 pubmed
    ..Oct-1. Ku-dependent mechanism of selective regulation of class switching to IgG and IgE and further suggest distinct co-evolution and shared CSR activation pathways in the Cgamma and Cepsilon as opposed to the Calpha1/Calpha2 loci. ..
  36. Nakamura M. [Analysis of disease-pathway by susceptibility genes in primary biliary cirrhosis]. Nihon Shokakibyo Gakkai Zasshi. 2013;110:1602-10 pubmed
  37. Pittman A, Webb E, Carvajal Carmona L, Howarth K, Di Bernardo M, Broderick P, et al. Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer. Hum Mol Genet. 2008;17:3720-7 pubmed publisher
    ..The absence of exonic mutations in any of the transcripts (FLJ45803, LOC120376, C11orf53 and POU2AF1) mapping to this region makes the association likely to be a consequence of non-coding effects on gene expression. ..
  38. Gashaw I, Dushaj O, Behr R, Biermann K, Brehm R, Rubben H, et al. Novel germ cell markers characterize testicular seminoma and fetal testis. Mol Hum Reprod. 2007;13:721-7 pubmed
    ..We also identified novel germ cell markers such as BOB1 (POU2AF1, OBF1) and prominin 1 (PROM1, CD133), which were significantly upregulated in seminoma specimens, compared to ..
  39. Sauter P, Matthias P. Coactivator OBF-1 makes selective contacts with both the POU-specific domain and the POU homeodomain and acts as a molecular clamp on DNA. Mol Cell Biol. 1998;18:7397-409 pubmed
    ..These data allow us to propose a model of the interaction between OBF-1 and the POU domain, whereby OBF-1 acts as a molecular clamp holding together the two moieties of the POU domain and the DNA. ..
  40. Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, et al. Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. Am J Hum Genet. 2012;91:721-8 pubmed publisher
    ..region, human leukocyte antigen (HLA), we identified two significant susceptibility loci, TNFSF15 (rs4979462) and POU2AF1 (rs4938534) (combined odds ratio [OR] = 1.56, p = 2.84 × 10(-14) for rs4979462, and combined OR = 1.39, p = 2...
  41. Lins K, Remenyi A, Tomilin A, Massa S, Wilmanns M, Matthias P, et al. OBF1 enhances transcriptional potential of Oct1. EMBO J. 2003;22:2188-98 pubmed
    ..that are either accessible (PORE sequence) or inaccessible (MORE sequence) to the B-cell-specific cofactor OBF1 (OcaB, Bob1)...
  42. Cavazzini F, De Wolf Peeters C, Wlodarska I. Alterations of loci encoding PU.1, BOB1, and OCT2 transcription regulators do not correlate with their suppressed expression in Hodgkin lymphoma. Cancer Genet Cytogenet. 2005;158:167-71 pubmed
    ..The genes encoding for these three respective transcription factors have been mapped at 11p11.2 (SPI1), 11q23.1 (POU2AF1), and 19q13.2 (POU2F2); these are chromosomes recurrently affected in HL. To check the genomic status of PU...
  43. Strubin M, Newell J, Matthias P. OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell. 1995;80:497-506 pubmed
    ..Thus, OBF-1 has all the properties expected for a B cell-specific transcriptional coactivator protein. ..
  44. Teitell M. OCA-B regulation of B-cell development and function. Trends Immunol. 2003;24:546-53 pubmed
    ..co-activator OCA-B [for Oct co-activator from B cells, also known as OBF-1 (OCT-binding factor-1) and Bob1] is not required for B-cell genesis but does regulate subsequent B-cell development and function...
  45. Henkel J, Du H, Yang P, Qyang Y, Kansra S, Ko M, et al. Bob1, a Gim5/MM-1/Pfd5 homolog, interacts with the MAP kinase kinase Byr1 to regulate sexual differentiation in the fission yeast, Schizosaccharomyces pombe. Differentiation. 2001;67:98-106 pubmed
    ..Here we describe the genetic and molecular characterization of a highly conserved protein, Bob1, which was identified from a two-hybrid screen for Byr1-interacting proteins...
  46. Boehm J, He Y, Greiner A, Staudt L, Wirth T. Regulation of BOB.1/OBF.1 stability by SIAH. EMBO J. 2001;20:4153-62 pubmed
    ..1/OBF.1 protein. Finally, B-cell receptor cross-linking also resulted in the degradation of BOB.1/OBF.1 and consequently reduced transcriptional activation of BOB.1/OBF.1-dependent reporters. ..
  47. Tiedt R, Bartholdy B, Matthias G, Newell J, Matthias P. The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1. EMBO J. 2001;20:4143-52 pubmed
    ..These data suggest that Siah-1 is part of a novel regulatory loop controlling the level of OBF-1 protein in B cells. ..
  48. Zhai K, Chang J, Hu J, Wu C, Lin D. Germline variation in the 3'-untranslated region of the POU2AF1 gene is associated with susceptibility to lymphoma. Mol Carcinog. 2017;56:1945-1952 pubmed publisher
    ..We found that rs1042752-located in the 3'-UTR of POU2AF1, which plays a vital role in lymphomagenesis-was significantly associated with lymphoma risk in a case-control ..
  49. AbdullGaffar B, Seliem R. De Novo Unclassifiable CD20-Negative Diffuse Large B-Cell Lymphoma: A Diagnostic and Therapeutic Challenge. Int J Surg Pathol. 2017;:1066896917735170 pubmed publisher
    ..The nodal neoplastic immunoblasts were positive for LCA, PAX5, CD30, OCT2, BOB1, MUM1, CD79a, and CD19. Ki67 proliferation index was 100%...
  50. Chasman D, Cepek K, Sharp P, Pabo C. Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface. Genes Dev. 1999;13:2650-7 pubmed
  51. Lee L, Stollar E, Chang J, Grossmann J, O Brien R, Ladbury J, et al. Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator. Biochemistry. 2001;40:6580-8 pubmed
    ..It acts synergistically with the B-cell-specific coactivator Bob1 (OCA-B, OBF-1) to stimulate transcription of immunoglobulin genes...
  52. Matsumiya H, Kawata K, Kamekura R, Tsubomatsu C, Jitsukawa S, Asai T, et al. High frequency of Bob1lo T follicular helper cells in florid reactive follicular hyperplasia. Immunol Lett. 2017;191:23-30 pubmed publisher
    ..were relatively tolerant to CD3-mediated activation-induced cell death (AICD) and also expressed lower levels of a Bob1 transcription coactivator and IL-4, which fosters the development of GC-B cells...
  53. Tomilin A, Remenyi A, Lins K, Bak H, Leidel S, Vriend G, et al. Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration. Cell. 2000;103:853-64 pubmed
    ..Our findings provide a paradigm of how specific POU dimer assemblies can differentially recruit a coregulatory activity with distinct transcriptional readouts. ..
  54. Luo Y, Ge H, Stevens S, Xiao H, Roeder R. Coactivation by OCA-B: definition of critical regions and synergism with general cofactors. Mol Cell Biol. 1998;18:3803-10 pubmed
  55. Luo Y, Roeder R. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol Cell Biol. 1995;15:4115-24 pubmed
    ..Further studies show that Ig promoter activation by Oct-1 and OCA-B requires still other general (USA-derived) cofactors and also provide indirect evidence that distinct Oct-interacting cofactors regulate H2B transcription. ..
  56. Duan H, Xiang H, Ma L, Boxer L. Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells. Oncogene. 2008;27:6720-8 pubmed publisher
    ..This study reveals a new aspect of the regulatory role of the IgH 3' enhancers on bcl-2 transcription in t(14;18) lymphomas. ..
  57. Chang J, Phillips K, Lundbäck T, Gstaiger M, Ladbury J, Luisi B. Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding. J Mol Biol. 1999;288:941-52 pubmed
    ..genes is controlled in part by the DNA-binding protein Oct-1 and the B cell-specific transcription co-activator, Bob1 (also known as OCA-B or OBF-1) that together form a complex on the Igkappa promoter...
  58. Rizzo R, Soffritti I, D Accolti M, Bortolotti D, Di Luca D, Caselli E. HHV-6A/6B Infection of NK Cells Modulates the Expression of miRNAs and Transcription Factors Potentially Associated to Impaired NK Activity. Front Microbiol. 2017;8:2143 pubmed publisher
    ..early increase of ATF3, JUN and FOXA2 by both species, whereas HHV-6A specifically induced a 15-fold decrease of POU2AF1, and HHV-6B an increase of FOXO1 and a decrease of ESR1...
  59. Massa S, Junker S, Schubart K, Matthias G, Matthias P. The OBF-1 gene locus confers B cell-specific transcription by restricting the ubiquitous activity of its promoter. Eur J Immunol. 2003;33:2864-74 pubmed
    ..Therefore, lineage commitment of the OBF-1 gene is promoter independent and is achieved by regulating the entire locus in a B cell-specific manner. ..