POSTN

Summary

Gene Symbol: POSTN
Description: periostin
Alias: OSF-2, OSF2, PDLPOSTN, periostin, osteoblast specific factor 2 (fasciclin I-like), periodontal ligament-specific periostin, periostin, osteoblast specific factor
Species: human
Products:     POSTN

Top Publications

  1. Yan W, Shao R. Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation. J Biol Chem. 2006;281:19700-8 pubmed
    ..We identify periostin, a mesenchyme-specific gene product, as a contributor to EMT and metastatic potential...
  2. Puppin C, Fabbro D, Dima M, Di Loreto C, Puxeddu E, Filetti S, et al. High periostin expression correlates with aggressiveness in papillary thyroid carcinomas. J Endocrinol. 2008;197:401-8 pubmed publisher
    b>Periostin is a mesenchyme-specific gene product, which acts as an adhesion molecule during bone formation and supports osteoblastic cell line attachment and spreading...
  3. Kikuchi Y, Kashima T, Nishiyama T, Shimazu K, Morishita Y, Shimazaki M, et al. Periostin is expressed in pericryptal fibroblasts and cancer-associated fibroblasts in the colon. J Histochem Cytochem. 2008;56:753-64 pubmed publisher
    b>Periostin is a unique extracellular matrix protein, deposition of which is enhanced by mechanical stress and the tissue repair process. Its significance in normal and neoplastic colon has not been fully clarified yet...
  4. Lv Y, Wang W, Jia W, Sun Q, Li J, Ma J, et al. High-level expression of periostin is closely related to metastatic potential and poor prognosis of hepatocellular carcinoma. Med Oncol. 2013;30:385 pubmed publisher
    b>Periostin (PN) is a kind of secreted glycoprotein, which is closely related to the metastatic potential and prognosis of many kinds of tumors in recent studies...
  5. Takeshita S, Kikuno R, Tezuka K, Amann E. Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochem J. 1993;294 ( Pt 1):271-8 pubmed
    ..On the basis of the amino acid sequence homology with fasciclin I, we suggest that OSF-2 functions as a homophilic adhesion molecule in bone formation. ..
  6. Gunia S, Jain A, Koch S, Denzinger S, Götz S, Niessl N, et al. Periostin expression correlates with pT-stage, grading and tumour size, and independently predicts cancer-specific survival in surgically treated penile squamous cell carcinomas. J Clin Pathol. 2013;66:297-301 pubmed publisher
    Overexpression of periostin, a secreted cell adhesion molecule, has been reported to enhance invasion and angiogenesis in squamous cell carcinomas (SCCs) derived from different anatomic sites...
  7. Li B, Wang L, Chi B. Upregulation of periostin prevents P53-mediated apoptosis in SGC-7901 gastric cancer cells. Mol Biol Rep. 2013;40:1677-83 pubmed publisher
    b>Periostin is frequently upregulated in human cancers including gastric cancer and implicated in cancer cell proliferation, invasion, and epithelial-mesenchymal transition...
  8. Sidhu S, Yuan S, Innes A, Kerr S, Woodruff P, Hou L, et al. Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci U S A. 2010;107:14170-5 pubmed publisher
    b>Periostin is considered to be a matricellular protein with expression typically confined to cells of mesenchymal origin...
  9. Kanno A, Satoh K, Masamune A, Hirota M, Kimura K, Umino J, et al. Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells. Int J Cancer. 2008;122:2707-18 pubmed publisher
    b>Periostin is a secretory protein that has been suggested to function as a cell adhesion molecule and promote the invasiveness or growth rate of tumors...

More Information

Publications65

  1. Utispan K, Thuwajit P, Abiko Y, Charngkaew K, Paupairoj A, Chau In S, et al. Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker. Mol Cancer. 2010;9:13 pubmed publisher
    ..b>Periostin (PN) is a multi-functional protein and has emerged as a promising marker for tumor progression...
  2. Li J, Sun G, Wei X, Tang W. Expression of periostin and its clinicopathological relevance in gastric cancer. World J Gastroenterol. 2007;13:5261-6 pubmed
    To investigate the expression and localization of periostin in gastric cancer and its clinical relevance. Reverse transcriptase polymerase chain reaction was used to measure periostin mRNA expression...
  3. Zhang Y, Zhang G, Li J, Tao Q, Tang W. The expression analysis of periostin in human breast cancer. J Surg Res. 2010;160:102-6 pubmed publisher
    To investigate the expression of periostin in breast cancer and its clinical relevance. Periostin mRNA expression in breast tissues was measured by RT-PCR. Periostin protein in breast tissues was evaluated by Western blot...
  4. Ben Q, Jin X, Liu J, Cai X, Yuan F, Yuan Y. Periostin, a matrix specific protein, is associated with proliferation and invasion of pancreatic cancer. Oncol Rep. 2011;25:709-16 pubmed publisher
    Overexpression of periostin is present in various malignant tumors and correlates with disease progression. However, its clinicopathological significance in pancreatic cancer is currently not known...
  5. Ouyang G, Liu M, Ruan K, Song G, Mao Y, Bao S. Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway. Cancer Lett. 2009;281:213-9 pubmed publisher
    b>Periostin is a secreted protein and has been shown to be frequently overexpressed in various types of human cancers...
  6. Tilman G, Mattiussi M, Brasseur F, van Baren N, Decottignies A. Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by both stromal and melanoma cells. Mol Cancer. 2007;6:80 pubmed
    Recently, periostin (POSTN), a gene encoding a protein with similarity to the fasciclin family and involved in cell survival and angiogenesis, has emerged as a promising marker for tumor progression in various types of human cancers...
  7. Qiu F, Shi C, Zheng J, Liu Y. Periostin mediates the increased pro-angiogenic activity of gastric cancer cells under hypoxic conditions. J Biochem Mol Toxicol. 2013;27:364-9 pubmed publisher
    This study was conducted to investigate the biological role of periostin in gastric cancer (GC) under hypoxia...
  8. Hong L, Sun H, Lv X, Yang D, Zhang J, Shi Y. Expression of periostin in the serum of NSCLC and its function on proliferation and migration of human lung adenocarcinoma cell line (A549) in vitro. Mol Biol Rep. 2010;37:2285-93 pubmed publisher
    b>Periostin is over expressed in many epithelial malignant cancers, including lung cancer, breast cancer, ovarian cancer and colon cancer. It is related with the progression and migration of breast and ovarian cancer cells in vitro...
  9. Siriwardena B, Kudo Y, Ogawa I, Kitagawa M, Kitajima S, Hatano H, et al. Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer. Br J Cancer. 2006;95:1396-403 pubmed
    ..We previously identified Periostin as the gene demonstrating the highest fold change expression in the invasive clone by comparing the ..
  10. Chang Y, Lee T, Li J, Lai T, Chua H, Chen C, et al. Differential expression of osteoblast-specific factor 2 and polymeric immunoglobulin receptor genes in nasopharyngeal carcinoma. Head Neck. 2005;27:873-82 pubmed
    ..In addition, expression of OSF-2 and pIgR is disassociated with the expression of their regulatory cytokines in NPC biopsy specimens, suggesting that the tumors may have altered responses to certain cytokines. ..
  11. Liu C, Huang S, Qin Z. Inhibition of periostin gene expression via RNA interference suppressed the proliferation, apoptosis and invasion in U2OS cells. Chin Med J (Engl). 2010;123:3677-83 pubmed
    b>Periostin originally designated osteoblast-specific factor 2 (OSF-2) is frequently found to be highly expressed in various types of human cancer cell lines in vitro and human cancer tissues in vivo...
  12. Fortunati D, Reppe S, Fjeldheim A, Nielsen M, Gautvik V, Gautvik K. Periostin is a collagen associated bone matrix protein regulated by parathyroid hormone. Matrix Biol. 2010;29:594-601 pubmed publisher
    b>Periostin is a 90 kDa secreted protein, originally identified in murine osteoblast-like cells, with a distribution restricted to collagen-rich tissues and certain tumors...
  13. Oku E, Kanaji T, Takata Y, Oshima K, Seki R, Morishige S, et al. Periostin and bone marrow fibrosis. Int J Hematol. 2008;88:57-63 pubmed publisher
    b>Periostin is a secreted protein that shares structural homology with the insect axon guidance protein fasciclin 1...
  14. Orecchia P, Conte R, Balza E, Castellani P, Borsi L, Zardi L, et al. Identification of a novel cell binding site of periostin involved in tumour growth. Eur J Cancer. 2011;47:2221-9 pubmed publisher
    b>Periostin (PN), a member of the fasciclin family of proteins, is a TGF-?-induced extracellular matrix protein involved in cell survival, angiogenesis, invasion and metastasis...
  15. Shimazaki M, Nakamura K, Kii I, Kashima T, Amizuka N, Li M, et al. Periostin is essential for cardiac healing after acute myocardial infarction. J Exp Med. 2008;205:295-303 pubmed publisher
    ..We show that periostin, which is a matricellular protein, is important for the cardiac healing process after AMI...
  16. Kim C, Isono T, Tambe Y, Chano T, Okabe H, Okada Y, et al. Role of alternative splicing of periostin in human bladder carcinogenesis. Int J Oncol. 2008;32:161-9 pubmed
    We have previously reported that the expression of periostin mRNA is significantly repressed in human bladder cancer tissues, and that periostin plays a role as a suppressive factor for invasion and metastasis in the progression of human ..
  17. Shao R, Bao S, Bai X, Blanchette C, Anderson R, Dang T, et al. Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol. 2004;24:3992-4003 pubmed
    ..Here, we describe the identification of periostin as a mesenchyme-specific gene whose acquired expression by human breast cancers leads to a significant ..
  18. Elliott C, Wang J, Guo X, Xu S, Eastwood M, Guan J, et al. Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair. J Cell Sci. 2012;125:121-32 pubmed publisher
    The matricellular protein periostin is expressed in the skin. Although periostin has been hypothesized to contribute to dermal homeostasis and repair, this has not been directly tested...
  19. Wang H, Wang Y, Jiang C. Stromal protein periostin identified as a progression associated and prognostic biomarker in glioma via inducing an invasive and proliferative phenotype. Int J Oncol. 2013;42:1716-24 pubmed publisher
    To explore the expression pattern, prognostic value and functional role of stromal periostin (POSTN) in glioma patients, POSTN expression was measured using the Agilent Whole Human Genome Oligo Microarray in 220 frozen glioma tissues...
  20. Bai Y, Kakudo K, Nakamura M, Ozaki T, Li Y, Liu Z, et al. Loss of cellular polarity/cohesiveness in the invasive front of papillary thyroid carcinoma and periostin expression. Cancer Lett. 2009;281:188-95 pubmed publisher
    Loss of cellular polarity/cohesiveness and periostin expression are involved in the epithelial-mesenchymal transition in the epithelial malignancies. Their roles in papillary thyroid carcinoma were studied...
  21. Baril P, Gangeswaran R, Mahon P, Caulee K, Kocher H, Harada T, et al. Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway. Oncogene. 2007;26:2082-94 pubmed
    ..Using gene expression profiling of pancreatic cancer tissues, we previously identified periostin as a potential diagnostic and therapeutic target...
  22. Zhu M, Fejzo M, Anderson L, Dering J, Ginther C, Ramos L, et al. Periostin promotes ovarian cancer angiogenesis and metastasis. Gynecol Oncol. 2010;119:337-44 pubmed publisher
    ..Our data indicate PN plays a critical role in both ovarian tumor angiogenesis and metastasis. Thus PN may represent a clinically effective new target for therapy of ovarian cancer. ..
  23. Romanos G, Asnani K, Hingorani D, Deshmukh V. PERIOSTIN: role in formation and maintenance of dental tissues. J Cell Physiol. 2014;229:1-5 pubmed publisher
    The matricellular protein periostin is strongly expressed in collagen-rich connective tissues such as periodontal ligaments (PDLs), skeletal muscle, adipose tissue, tendons, skin, and bone...
  24. Tischler V, Fritzsche F, Wild P, Stephan C, Seifert H, Riener M, et al. Periostin is up-regulated in high grade and high stage prostate cancer. BMC Cancer. 2010;10:273 pubmed publisher
    Expression of periostin is an indicator of epithelial-mesenchymal transition in cancer but a detailed analysis of periostin expression in prostate cancer has not been conducted so far...
  25. Riener M, Fritzsche F, Soll C, Pestalozzi B, Probst Hensch N, Clavien P, et al. Expression of the extracellular matrix protein periostin in liver tumours and bile duct carcinomas. Histopathology. 2010;56:600-6 pubmed publisher
    To study the relevance of periostin, known to be involved in epithelial-mesenchymal transition (EMT), in hepatocellular and bile duct cancer...
  26. Wang W, Sun Q, He Y, Ma D, Xie M, Ji C, et al. Overexpression of periostin is significantly correlated to the tumor angiogenesis and poor prognosis in patients with esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 2014;7:593-601 pubmed
    Recent studies have found that periostin (PN), as a kind of secreted glycoprotein, is closely related to the metastatic potential and prognosis of many kinds of tumors...
  27. Gillan L, Matei D, Fishman D, Gerbin C, Karlan B, Chang D. Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility. Cancer Res. 2002;62:5358-64 pubmed
    b>Periostin (PN) is a secreted protein that shares a structural homology to the axon guidance protein fasciclin I in insects. Previously, we reported that PN expression is up-regulated in epithelial ovarian tumors...
  28. Takanami I, Abiko T, Koizumi S. Expression of periostin in patients with non-small cell lung cancer: correlation with angiogenesis and lymphangiogenesis. Int J Biol Markers. 2008;23:182-6 pubmed
    The aim of this study was to evaluate periostin expression measured immunohistochemically in patients with non-small cell lung cancer (NSCLC) and to determine its association with clinical features, prognosis, angiogenesis, and ..
  29. Kashima T, Nishiyama T, Shimazu K, Shimazaki M, Kii I, Grigoriadis A, et al. Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos-overexpressing bone lesions. Hum Pathol. 2009;40:226-37 pubmed publisher
    ..In this study, we examined the expression of the bone-related extracellular matrix protein, periostin, and its known receptor, integrin alpha v beta 3 (CD51/61), in normal bones as well as in fibrous dysplasia...
  30. Fukushima N, Kikuchi Y, Nishiyama T, Kudo A, Fukayama M. Periostin deposition in the stroma of invasive and intraductal neoplasms of the pancreas. Mod Pathol. 2008;21:1044-53 pubmed publisher
    ..Recently, by transcriptome analysis, periostin was identified as a significantly highly expressed gene in pancreatic stellate cells...
  31. Kim C, Yoshioka N, Tambe Y, Kushima R, Okada Y, Inoue H. Periostin is down-regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and in vivo metastasis of cancer cells. Int J Cancer. 2005;117:51-8 pubmed
    We have previously reported that expression of periostin mRNA is markedly reduced in a variety of human cancer cell lines, suggesting that downregulation of periostin mRNA expression is correlated with the development of human cancers...
  32. Kim B, Olzmann J, Choi S, Ahn S, Kim T, Cho H, et al. Corneal dystrophy-associated R124H mutation disrupts TGFBI interaction with Periostin and causes mislocalization to the lysosome. J Biol Chem. 2009;284:19580-91 pubmed publisher
    ..Here we report the identification of periostin, a molecule that is highly related to TGFBI, as a specific TGFBI-binding partner...
  33. Song Z, Qin Z. [Expression of periostin and the effect of hydrocortisone on it in human fibroblasts of scar]. Beijing Da Xue Xue Bao Yi Xue Ban. 2008;40:301-5 pubmed
    To probe into the role of periostin in the formation of scars and investigate its reaction to hydrocortisone...
  34. Fujimoto K, Kawaguchi T, Nakashima O, Ono J, Ohta S, Kawaguchi A, et al. Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma. Oncol Rep. 2011;25:1211-6 pubmed publisher
    ..b>Periostin is a secreted protein from stromal cells and regulates the development of cancer cells through interaction with ..
  35. Forsti A, Jin Q, Altieri A, Johansson R, Wagner K, Enquist K, et al. Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis. Breast Cancer Res Treat. 2007;101:83-93 pubmed
    ..Up-regulation of KDR by periostin (POSTN) induces angiogenesis...
  36. Wallace D, Quante M, Reif G, Nivens E, Ahmed F, Hempson S, et al. Periostin induces proliferation of human autosomal dominant polycystic kidney cells through alphaV-integrin receptor. Am J Physiol Renal Physiol. 2008;295:F1463-71 pubmed publisher
    ..In a microarray analysis of cultured human ADPKD cyst epithelial cells, periostin mRNA was overexpressed 15-fold compared with normal human kidney (NHK) cells...
  37. Snider P, Standley K, Wang J, Azhar M, Doetschman T, Conway S. Origin of cardiac fibroblasts and the role of periostin. Circ Res. 2009;105:934-47 pubmed publisher
    ..In this review, we summarize the present understanding regarding the function of Periostin, a useful marker of the noncardiomyocyte lineages, and its role during cardiac morphogenesis...
  38. Utispan K, Sonongbua J, Thuwajit P, Chau In S, Pairojkul C, Wongkham S, et al. Periostin activates integrin ?5?1 through a PI3K/AKT?dependent pathway in invasion of cholangiocarcinoma. Int J Oncol. 2012;41:1110-8 pubmed publisher
    b>Periostin (PN) is mainly produced from stromal fibroblasts in cholangiocarcinoma (CCA) and shows strong impact in cancer promotion. This work aimed to investigate the mechanism that PN uses to drive CCA invasion...
  39. Michaylira C, Wong G, Miller C, Gutierrez C, Nakagawa H, Hammond R, et al. Periostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor-invasive signature in esophageal cancer. Cancer Res. 2010;70:5281-92 pubmed publisher
    ..Here, we report that periostin, a highly expressed cell adhesion molecule, is a key component of a novel tumor-invasive signature obtained from ..
  40. Sen K, Lindenmeyer M, Gaspert A, Eichinger F, Neusser M, Kretzler M, et al. Periostin is induced in glomerular injury and expressed de novo in interstitial renal fibrosis. Am J Pathol. 2011;179:1756-67 pubmed publisher
    ..b>Periostin showed the highest induction, and its transcript levels correlated negatively with glomerular filtration rate in ..
  41. Li G, Jin R, Norris R, Zhang L, Yu S, Wu F, et al. Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway. Atherosclerosis. 2010;208:358-65 pubmed publisher
    ..Previous studies have shown that periostin (PN), a novel ECM protein, is upregulated in rat carotid artery after balloon injury, and growth factor-..
  42. Morra L, Rechsteiner M, Casagrande S, Duc Luu V, Santimaria R, Diener P, et al. Relevance of periostin splice variants in renal cell carcinoma. Am J Pathol. 2011;179:1513-21 pubmed publisher
    The extracellular matrix N-glycoprotein periostin is thought to enhance tumor invasion. In this study, the expression patterns of periostin and its splice isoforms were investigated in renal cell carcinoma (RCC)...
  43. Li M, Li C, Li D, Xie Y, Shi J, Li G, et al. Periostin, a stroma-associated protein, correlates with tumor invasiveness and progression in nasopharyngeal carcinoma. Clin Exp Metastasis. 2012;29:865-77 pubmed publisher
    ..In this study, periostin was identified to be significantly up-regulated in NPC stroma compared with NNM stroma and the result was ..
  44. Windischhofer W, Huber E, Rossmann C, Semlitsch M, Kitz K, Rauh A, et al. LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis. Biochimie. 2012;94:1997-2005 pubmed publisher
    ..LPA-induced Egr-1 upregulation was accompanied by a time-dependent decrease of periostin (previously called osteoblast-specific factor 2), a cell adhesion protein for pre-osteoblasts...
  45. Coutu D, Wu J, Monette A, Rivard G, Blostein M, Galipeau J. Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells. J Biol Chem. 2008;283:17991-8001 pubmed publisher
    ..The most abundant Gla-containing protein secreted by MSCs was identified as periostin, a previously unrecognized gamma-carboxylated protein...
  46. Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, et al. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell. 2004;5:329-39 pubmed
    ..Here we report that acquired expression of periostin by colon cancer cells greatly promoted metastatic development of colon tumors...
  47. Blanchard C, Mingler M, McBride M, Putnam P, Collins M, Chang G, et al. Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses. Mucosal Immunol. 2008;1:289-96 pubmed publisher
    b>Periostin is an extracellular matrix protein that has been primarily studied in the context of the heart, where it has been shown to promote cardiac repair and remodeling...
  48. Sasaki H, Dai M, Auclair D, Fukai I, Kiriyama M, Yamakawa Y, et al. Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas. Cancer. 2001;92:843-8 pubmed
    b>Periostin protein shares structural and sequence homology with fasciclin I, which is an insect adhesion molecule. Periostin has a typical signal peptide at the N-terminal end, which suggests that it is a secreted protein...
  49. Kii I, Nishiyama T, Li M, Matsumoto K, Saito M, Amizuka N, et al. Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. J Biol Chem. 2010;285:2028-39 pubmed publisher
    ..Here we show that periostin, a matricellular protein, promotes incorporation of tenascin-C into the ECM and organizes a meshwork ..
  50. Choi K, Yun J, Lee I, Heo S, Shin S, Jeon E, et al. Lysophosphatidic acid-induced expression of periostin in stromal cells: Prognoistic relevance of periostin expression in epithelial ovarian cancer. Int J Cancer. 2011;128:332-42 pubmed publisher
    ..Here we report periostin, an extracellular matrix protein, as an LPA-induced protein in stromal cells and as a prognostic marker in ..
  51. Vidyasekar P, Shyamsunder P, Santhakumar R, Arun R, Verma R. A simplified protocol for the isolation and culture of cardiomyocytes and progenitor cells from neonatal mouse ventricles. Eur J Cell Biol. 2015;94:444-52 pubmed publisher
    ..Progenitor markers CD44, CD90, and extracellular proteins, periostin and vimentin demonstrated the preservation of cellular heterogeneity in such cultures...
  52. Ikpegbu E, Basta L, Clements D, Fleming R, Vincent T, Buttle D, et al. FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression. J Cell Physiol. 2017;: pubmed publisher
    ..01) increases in Phex and Dmp1 (osteocyte markers) expression and decreases in Col1a1, Postn, Bglap, and Alpl (osteoblast markers) expression...
  53. Crawford J, Raykha C, Charles D, Gan B, O Gorman D. WT1 expression is increased in primary fibroblasts derived from Dupuytren's disease tissues. J Cell Commun Signal. 2015;9:347-52 pubmed publisher
    ..molecular similarities to malignant tumours, including increased levels of ß-catenin, onco-fetal fibronectin, periostin and insulin-like growth factor (IGF)-II...
  54. Xiao S, Gao Y, Cheung C, Bow C, Lau K, Sham P, et al. Association of CDX1 binding site of periostin gene with bone mineral density and vertebral fracture risk. Osteoporos Int. 2012;23:1877-87 pubmed publisher
    b>Periostin (POSTN) as a regulator of osteoblast differentiation and bone formation may affect susceptibility to osteoporosis...
  55. Matsuzawa M, Arai C, Nomura Y, Murata T, Yamakoshi Y, Oida S, et al. Periostin of human periodontal ligament fibroblasts promotes migration of human mesenchymal stem cell through the αvβ3 integrin/FAK/PI3K/Akt pathway. J Periodontal Res. 2015;50:855-63 pubmed publisher
    ..b>Periostin, which is highly expressed in the fibroblasts in the PDL, has been widely discussed in relation to collagen ..
  56. Annis D, Ma H, Balas D, Kumfer K, Sandbo N, Potts G, et al. Absence of Vitamin K-Dependent γ-Carboxylation in Human Periostin Extracted from Fibrotic Lung or Secreted from a Cell Line Engineered to Optimize γ-Carboxylation. PLoS ONE. 2015;10:e0135374 pubmed publisher
    b>Periostin (PN, gene name POSTN) is an extracellular matrix protein that is up-regulated in bronchial epithelial cells and lung fibroblasts by TH-2 cytokines...