PON1

Summary

Gene Symbol: PON1
Description: paraoxonase 1
Alias: ESA, MVCD5, PON, A-esterase 1, K-45, PON 1, aromatic esterase 1, arylesterase 1, arylesterase B-type, esterase A, paraoxonase B-type, serum aryldiakylphosphatase, serum aryldialkylphosphatase 1
Species: human

Top Publications

  1. ncbi Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities
    Dragomir I Draganov
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Lipid Res 46:1239-47. 2005
  2. doi The three-gene paraoxonase family: physiologic roles, actions and regulation
    Louis Philippe Precourt
    Research Centre, CHU Sainte Justine, Department of Nutrition, Universite de Montreal, Montreal, Quebec, Canada
    Atherosclerosis 214:20-36. 2011
  3. ncbi The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family
    S L Primo-Parmo
    Department of Anesthesiology, University of Michigan Medical School, R5036 Kresge II Building, Ann Arbor, Michigan, 48109 0572, USA
    Genomics 33:498-507. 1996
  4. pmc Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk
    Tamali Bhattacharyya
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 299:1265-76. 2008
  5. ncbi Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing
    Egon A Ozer
    Department of Internal Medicine Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    FEMS Microbiol Lett 253:29-37. 2005
  6. doi The role of paraoxonase 1 in the detoxification of homocysteine thiolactone
    Hieronim Jakubowski
    Department of Biochemistry and Biotechnology, University of Life Sciences, Poznan, Poland
    Adv Exp Med Biol 660:113-27. 2010
  7. pmc Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis
    Issa J Dahabreh
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    Genet Med 12:606-15. 2010
  8. ncbi The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    J Lipid Res 47:2492-502. 2006
  9. pmc Human PON1, a biomarker of risk of disease and exposure
    C E Furlong
    University of Washington, Department of Medicine Div of Medical Genetics, Seattle, WA, United States
    Chem Biol Interact 187:355-61. 2010
  10. doi Paraoxonase-1 status in Crohn's disease and ulcerative colitis
    Dorota Boehm
    Department of Medical Biochemistry, Wroclaw Medical University, Wroclaw, Poland
    Inflamm Bowel Dis 15:93-9. 2009

Detail Information

Publications285 found, 100 shown here

  1. ncbi Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities
    Dragomir I Draganov
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Lipid Res 46:1239-47. 2005
    The paraoxonase (PON) gene family in humans has three members, PON1, PON2, and PON3. Their physiological role(s) and natural substrates are uncertain...
  2. doi The three-gene paraoxonase family: physiologic roles, actions and regulation
    Louis Philippe Precourt
    Research Centre, CHU Sainte Justine, Department of Nutrition, Universite de Montreal, Montreal, Quebec, Canada
    Atherosclerosis 214:20-36. 2011
    The paraoxonase (PON) gene family is composed of three members (PON1, PON2, PON3) that share considerable structural homology and are located adjacently on chromosome 7 in humans...
  3. ncbi The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family
    S L Primo-Parmo
    Department of Anesthesiology, University of Michigan Medical School, R5036 Kresge II Building, Ann Arbor, Michigan, 48109 0572, USA
    Genomics 33:498-507. 1996
    A physiological role for paraoxonase (PON1) is still uncertain, but it catalyzes the hydrolysis of toxic organophosphates. Evidence that the human genome contains two PON1-like genes, designated PON2 and PON3, is presented here...
  4. pmc Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk
    Tamali Bhattacharyya
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 299:1265-76. 2008
    Paraoxonase 1 (PON1) is reported to have antioxidant and cardioprotective properties...
  5. ncbi Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing
    Egon A Ozer
    Department of Internal Medicine Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    FEMS Microbiol Lett 253:29-37. 2005
    ..We found that paraoxonase 1 (PON1), a mammalian lactonase with an unknown natural substrate, hydrolyzed the P. aeruginosa acyl-HSL 3OC12-HSL...
  6. doi The role of paraoxonase 1 in the detoxification of homocysteine thiolactone
    Hieronim Jakubowski
    Department of Biochemistry and Biotechnology, University of Life Sciences, Poznan, Poland
    Adv Exp Med Biol 660:113-27. 2010
    ..One such mechanism involves paraoxonase 1 (PON1), which has the ability to hydrolyze Hcy-thiolactone...
  7. pmc Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis
    Issa J Dahabreh
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    Genet Med 12:606-15. 2010
    Paraoxonase 1 (PON1) polymorphisms have been implicated as risk factors for coronary artery disease, but the results of genetic association studies on the related phenotype of ischemic stroke are inconclusive...
  8. ncbi The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    J Lipid Res 47:2492-502. 2006
    Serum paraoxonase (PON1) is a HDL-associated enzyme exhibiting potentially antiatherogenic properties. Here, we examined the common PON1-192R/Q human polymorphism...
  9. pmc Human PON1, a biomarker of risk of disease and exposure
    C E Furlong
    University of Washington, Department of Medicine Div of Medical Genetics, Seattle, WA, United States
    Chem Biol Interact 187:355-61. 2010
    Human paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated serum enzyme that exhibits a broad substrate specificity...
  10. doi Paraoxonase-1 status in Crohn's disease and ulcerative colitis
    Dorota Boehm
    Department of Medical Biochemistry, Wroclaw Medical University, Wroclaw, Poland
    Inflamm Bowel Dis 15:93-9. 2009
    Paraoxonase 1 (PON1) is an extracellular enzyme, which in the gastrointestinal tract may act as a local detoxifier, antioxidant, immunomodulator, and/or quorum-quenching factor. There are no data on PON1 activity in Crohn's disease (CD).
  11. pmc Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women
    Kim G Harley
    Center for Environmental Research and Children s Health, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e23923. 2011
    ..We explored whether paraoxonase (PON1), a key enzyme involved in detoxification of OPs, could be an effect modifier in this association.
  12. doi Maternal exposure to floricultural work during pregnancy, PON1 Q192R polymorphisms and the risk of low birth weight
    G Moreno-Banda
    Population Health Research Center, National Institute of Public Health, Avenida Universidad 655, Colonia Santa Maria Ahuacatitlan, 62508 Cuernavaca, Morelos, Mexico
    Sci Total Environ 407:5478-85. 2009
    ..Paraoxonase (PON1) detoxifies organophosphates by cleavage of active oxons...
  13. pmc Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes
    S Adkins
    Department of Environmental and Industrial Health, School of Public Health, University of Michigan, Ann Arbor 48109 0572
    Am J Hum Genet 52:598-608. 1993
    ..Pedigree analysis showed both polymorphisms to be inherited in the expected Mendelian manner and confirmed that only the 191 polymorphism showed concordance with the serum paraoxonase/arylesterase phenotypes...
  14. doi Paraoxonase-1 is a major determinant of clopidogrel efficacy
    Heleen J Bouman
    Department of Cardiology, St Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands
    Nat Med 17:110-6. 2011
    ..Using in vitro metabolomic profiling techniques, we identified paraoxonase-1 (PON1) as the crucial enzyme for clopidogrel bioactivation, with its common Q192R polymorphism determining the rate of ..
  15. ncbi Lack of replication of genetic associations with human longevity
    Valeria Novelli
    Genetic Department, IRCCS Multimedica, Via Milanese 300, Sesto S Giovanni Milan, 20099, Italy
    Biogerontology 9:85-92. 2008
    ..tested Klotho (KL)-VS variant (rs952706), Cholesteryl Ester Transfer Protein (CETP) I405V (rs5882), Paraoxonase 1 (PON1) Q192R (rs662), Apolipoprotein C-III (APOC3) -641C/A (rs2542052), Microsomal Transfer Protein (MTP) -493G/T (..
  16. doi The role of polymorphisms within paraoxonases (192 Gln/Arg in PON1 and 311Ser/Cys in PON2) in the modulation of cardiovascular risk: a pilot study
    Anna Gluba
    Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Zeromskiego 113, Lodz, Poland
    Angiology 61:157-65. 2010
    ..We evaluated the influence of 2 polymorphisms within PON1 (192 Gln/ Arg) and PON2 (311 Ser/Cys) genes in 407 young Poles: 273 patients who experienced a first myocardial ..
  17. doi Four genetic polymorphisms of paraoxonase gene and risk of coronary heart disease: a meta-analysis based on 88 case-control studies
    Mingsong Wang
    Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, China
    Atherosclerosis 214:377-85. 2011
    The human paraoxonase (PON) is calcium dependent HDL associated ester hydrolase which has attracted considerable attention as a candidate gene for coronary heart disease based on its enzyme function as a key factor in lipoprotein ..
  18. ncbi Paraoxonase Gln-Arg(192) and Leu-Met(55) gene polymorphisms and enzyme activity in a population with a low rate of coronary heart disease
    Natalia Ferre
    Centre de Recerca Biomedica, Hospital Universitari de Sant Joan, Reus, Spain
    Clin Biochem 35:197-203. 2002
    To assess whether paraoxonase (PON1) polymorphisms at positions 55 and 192 and/or their phenotypic expressions influence the risk of myocardial infarction (MI) in Spanish population.
  19. doi Association between PON1 activity and coronary heart disease risk: a meta-analysis based on 43 studies
    Yuan Zhao
    The Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China
    Mol Genet Metab 105:141-8. 2012
    Paraoxonase 1 (PON1) is reported to have antioxidant and cardioprotective properties...
  20. doi PON1Q192R genetic polymorphism modifies organophosphorous pesticide effects on semen quality and DNA integrity in agricultural workers from southern Mexico
    N Perez-Herrera
    Sección Externa de Toxicología, CINVESTAV IPN, PO Box 14 760, Mexico City, 07360, Mexico
    Toxicol Appl Pharmacol 230:261-8. 2008
    ..including organophosphorous (OP) insecticides, has been associated with poor semen quality, and paraoxonase (PON1), an enzyme involved in OP deactivation, may have a role on their susceptibility, due to PON1 polymorphisms...
  21. doi Effect of paraoxonase-1 polymorphism on clinical outcomes in patients treated with clopidogrel after an acute myocardial infarction
    T Simon
    Assistance Publique Hopitaux de Paris APHP, Hopital St Antoine, URC EST, Paris, France
    Clin Pharmacol Ther 90:561-7. 2011
    Paraoxonase-1 (PON1) Q192R polymorphism was recently suggested to determine per se clopidogrel response on major cardiovascular events (MACEs)...
  22. ncbi Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants
    Clement E Furlong
    Genome Sciences and Medicine, Division of Medical Genetics, University of Washington, Box 357720, Seattle, WA 98195 7720, USA
    Neurotoxicology 26:651-9. 2005
    ..are due largely to differences in catalytic efficiency or abundance of the HDL-associated enzyme, paraoxonase (PON1)...
  23. doi Differential effects of paraoxonase 1 (PON1) polymorphisms on cancer risk: evidence from 25 published studies
    Dai Hua Fang
    Central Laboratory, Xuzhou Children s Hospital, Xuzhou, Jiangsu Province, China
    Mol Biol Rep 39:6801-9. 2012
    ..b>PON1 activity varies widely among individuals, which is in part related to two common nonsynonymous polymorphisms in the ..
  24. ncbi The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status
    Laura S Rozek
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    J Lipid Res 46:1888-95. 2005
    Paraoxonase (PON1) is an HDL-associated enzyme. Low PON1 activity predicts vascular disease status and is a more reliable predictor of vascular disease than are functional PON1 genotypes...
  25. ncbi Serum PON-1 activity but not Q192R polymorphism is related to the extent of atherosclerosis
    Ahmet Bayrak
    Department of Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    J Atheroscler Thromb 19:376-84. 2012
    Paraoxonase-1 (PON1) is an antioxidant enzyme located in high density lipoprotein (HDL). PON1 was defined as a protective factor against atherosclerosis...
  26. doi Paraoxonase activity in healthy, diabetic, and hemodialysis patients
    Nagba Yendoubé Gbandjaba
    Laboratoire de recherche sur les lipoprotéines et l athérosclérose, Unité Associée au CNRST URAC 34, Universite Hassan II, Faculté des Sciences Ben M sik, Casablanca, Morocco
    Clin Biochem 45:470-4. 2012
    Paraoxonase 1 (PON1) is mainly complexed to HDL and is responsible, at least in part, for their antioxidant properties...
  27. pmc The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, UK
    BMC Genet 5:17. 2004
    There have been inconsistent results from case-control studies assessing the association of the PON1 Q192R polymorphism with coronary heart disease (CHD)...
  28. pmc Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis
    J L Reny
    Division of General Internal Medicine, Faculty of MedicineGeneva University Hospital, Geneva, Switzerland
    J Thromb Haemost 10:1242-51. 2012
    ..Paraoxonase 1 (PON1) enzyme activity is modulated by the PON1-Q192R variant (rs662) and was recently suggested to be strongly involved ..
  29. ncbi Association of the M55L and Q192R paraoxonase gene polymorphisms with age-related macular degeneration
    Paul N Baird
    Centre for Eye Research Australia, University of Melbourne, East Melbourne, Australia
    Am J Ophthalmol 138:665-6. 2004
    To investigate the reported association of the two single-nucleotide polymorphisms (SNPs) of the paraoxonase gene (PON1), Met-Leu 55 (M55L) and Gln-Arg 192 (Q192R), in individuals of Anglo-Celtic descent who have age-related macular ..
  30. pmc The roles of PON1 and PON2 in cardiovascular disease and innate immunity
    Diana M Shih
    Division of Cardiology, Department of Medicine, University of California, Los Angeles, California 90095 1679, USA
    Curr Opin Lipidol 20:288-92. 2009
    The paraoxonase (PON) gene family includes three members, PON1, PON2, and PON3. In-vitro and mouse studies have demonstrated that all three PONs are atheroprotective...
  31. doi Human paraoxonase-1 activity in childhood obesity and its relation to leptin and adiponectin levels
    Peter Koncsos
    First Department of Medicine, University of Debrecen, Debrecen, Hungary
    Pediatr Res 67:309-13. 2010
    Childhood obesity is a predisposing factor for adult cardiovascular diseases. Human serum paraoxonase (PON1) may protect against atherosclerosis by hydrolyzing lipid peroxides in oxidized LDL...
  32. ncbi Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2
    Sara Deakin
    Clinical Diabetes Unit, Division of Endocrinology and Diabetes, Medical Faculty, University Hospital, Geneva, Switzerland
    Arterioscler Thromb Vasc Biol 23:2083-9. 2003
    ..The present study examined the influence of simvastatin on paraoxonase expression and serum paraoxonase levels...
  33. ncbi Human paraoxonase-1 gene expression by HepG2 cells is downregulated by interleukin-1beta and tumor necrosis factor-alpha, but is upregulated by interleukin-6
    Yoshitaka Kumon
    Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kohasu Okoh Cho, Nankoku, Kochi 783 8505, Japan
    Life Sci 73:2807-15. 2003
    Recent studies have demonstrated that human paraoxonase-1 (PON1) associated with HDL, plays a role for anti-atherosclerotic effects of HDL, however, the relationships between PON1 and inflammatory cytokines remain unclear...
  34. pmc Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children
    Karen Huen
    Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, California, USA
    Environ Mol Mutagen 52:105-16. 2011
    Paraoxonase 1 (PON1) prevents oxidation of low-density lipoproteins and inactivates toxic oxon derivatives of organophosphate pesticides (OPs)...
  35. doi Continuous reduction of plasma paraoxonase activity with increasing dialysis vintage in hemodialysis patients
    Bernhard F Henning
    Medical Klinik I, Marienhospital Herne, Ruhr Universitat Bochum, Bochum, Germany
    Ther Apher Dial 14:572-6. 2010
    ..Compared to hemodialysis patients with PON 1, patients with PON 2 or 3 showed higher conversion rates for 4-nitrophenylacetate...
  36. doi Q192R polymorphism of the paraoxonase-1 gene as a risk factor for obesity in Portuguese women
    Luisa Veiga
    Escola Superior de Tecnologia de Saúde de Lisboa, Avenida D João II, Lote 4 69 01, Parque das Nações, 1990 096 Lisboa, Portugal
    Eur J Endocrinol 164:213-8. 2011
    Obesity became a major public health problem as a result of its increasing prevalence worldwide. Paraoxonase-1 (PON1) is an esterase able to protect membranes and lipoproteins from oxidative modifications...
  37. doi Paraoxonase-1 (PON1) activity as a risk factor for atherosclerosis in chronic renal failure patients
    Saeed Abdelwhab Saeed
    Departments of Nephrology, Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Hemodial Int 12:471-9. 2008
    ..Basal paraoxonase-1 (PON1), salt-stimulated PON1, and arylesterase activity correlate with BUN, but only basal PON1 and salt-stimulated PON1 ..
  38. pmc Paraoxonase 1 status as a risk factor for disease or exposure
    Rebecca J Richter
    Departments of Medicine Division of Medical Genetics and Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Adv Exp Med Biol 660:29-35. 2010
    Human paraoxonase 1 (PON1) has broad substrate specificity and has been shown to protect against exposure to some organophosphorus (OP) insecticides due to its ability to hydrolyze toxic metabolites of some organophosphorothioate ..
  39. pmc Paraoxonase gene polymorphism in south-western Korean population
    Byoung Soo Shin
    Department of Neurology, Chonbuk National University Hospital and Medical School, Deokjin gu, Jeonju, Korea
    J Korean Med Sci 24:561-6. 2009
    ..The genotype distribution of PON1 at position 55 was LL=0.886, LM=0.114; and at position 192 was QQ=0.406, QR=0.594...
  40. ncbi Purification of rabbit and human serum paraoxonase
    C E Furlong
    Division of Medical Genetics, School of Medicine, University of Washington, Seattle 98195
    Biochemistry 30:10133-40. 1991
    ..Human serum paraoxonase was purified by a similar procedure, and ten residues of the amino terminus were sequenced by gas-phase procedures. One amino acid difference between the first ten residues of human and rabbit was observed...
  41. ncbi Paraoxonase 1 and atherosclerosis: is the gene or the protein more important?
    Mike Mackness
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Free Radic Biol Med 37:1317-23. 2004
    ..High-density lipoprotein (HDL) paraoxonase 1 (PON1) retards the oxidation of LDL and is a major antiatherosclerotic component of HDL...
  42. pmc Paraoxonase 1 (PON1) status and substrate hydrolysis
    Rebecca J Richter
    Department of Medicine Division of Medical Genetics, Box 357720, University of Washington, Seattle, WA 98195 7720, USA
    Toxicol Appl Pharmacol 235:1-9. 2009
    Paraoxonase 1 (PON1) hydrolyzes a number of organophosphorus (OP) compounds including insecticides and nerve agents. The in vivo efficacy of PON1 to protect against a specific OP exposure depends on the catalytic efficiency of hydrolysis...
  43. doi Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention
    Jakub J Regieli
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Coll Cardiol 54:1238-45. 2009
    We investigated the effects of paraoxonase (PON)-1 variants on long-term clinical outcome in patients with coronary artery disease (CAD).
  44. pmc Determinants of variation in human serum paraoxonase activity
    D L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Heredity (Edinb) 102:147-54. 2009
    Paraoxonase-1 (PON1) is associated with high-density lipoprotein (HDL) particles and is believed to contribute to antiatherogenic properties of HDLs...
  45. ncbi Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease
    Gail P Jarvik
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Wash, USA
    Arterioscler Thromb Vasc Biol 23:1465-71. 2003
    The effects of paraoxonase (PON1) activity and of genetic variation in the PON1 promoter and coding region on carotid artery disease (CAAD) were investigated.
  46. doi Human tissue distribution of paraoxonases 1 and 2 mRNA
    Bharti Mackness
    Centre de Recerca Biomedica, Hospital Universitari de Sant Joan, C Sant Joan s n, Reus, Catalunya, Spain
    IUBMB Life 62:480-2. 2010
    ..b>PON1 mRNA was restricted to adult kidney, liver, and colon as well as fetal liver, whereas PON2 mRNA was more widely ..
  47. ncbi Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration
    T Ikeda
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Am J Ophthalmol 132:191-5. 2001
    ..Our purpose is to evaluate the hypothesis that paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level play a role in the occurrence of exudative age-related macular degeneration...
  48. ncbi TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease
    Christopher S Carlson
    The Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, The University of Washington, Seattle, USA
    J Lipid Res 47:1014-24. 2006
    Paraoxonase 1 (PON1) activity is consistently predictive of vascular disease, although the genotype at four functional PON1 polymorphisms is not...
  49. ncbi Serum paraoxonase activity: a new additional test for the improved evaluation of chronic liver damage
    Natalia Ferre
    Centre de Recerca Biomèdica and Servei de Medicina Interna, Institut de Recerca en Ciències de la Salut IRCIS, Hospital Universitari de Sant Joan, C Sant Joan s n, 43201 Reus, Catalunya, Spain
    Clin Chem 48:261-8. 2002
    Paraoxonase 1 (PON1) is an ester hydrolase present in serum and in the liver...
  50. ncbi The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Lipid Res 48:1637-46. 2007
    Serum paraoxonase (PON1) is a lipolactonase that associates with HDL-apolipoprotein A-I (HDL-apoA-I) and thereby plays a role in the prevention of atherosclerosis...
  51. ncbi Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies
    Jeremy G Wheeler
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 363:689-95. 2004
    ....
  52. ncbi Human paraoxonase-1 overexpression inhibits atherosclerosis in a mouse model of metabolic syndrome
    Bharti Mackness
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Arterioscler Thromb Vasc Biol 26:1545-50. 2006
    ..Paraoxonase1 (PON1), a high-density lipoprotein (HDL)-associated antioxidant enzyme that prevents the oxidation of low-density ..
  53. ncbi The combined effect of paraoxonase promoter and coding region polymorphisms on the risk of arterial ischemic stroke among young adults
    Barbara Voetsch
    Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA
    Arch Neurol 61:351-6. 2004
    Serum paraoxonase (PON1) is a high-density lipoprotein-associated esterase with antioxidant and antiatherogenic properties that has recently been implicated in the pathogenesis of cardiovascular disease...
  54. ncbi Paraoxonase promoter polymorphism T(-107)C and relative paraoxonase deficiency as determinants of risk of coronary artery disease
    I Leviev
    Clinical Diabetes Unit, Division of Endocrinology and Diabetology, University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    J Mol Med (Berl) 79:457-63. 2001
    This study tested the hypothesis that promoter polymorphism T(-107)C of the human paraoxonase gene (PON1) is associated with risk of coronary disease. Participants (n=897) were recruited from a cardiology department...
  55. doi Relation of PON1 and CYP1A1 genetic polymorphisms to clinical findings in a cross-sectional study of a Greek rural population professionally exposed to pesticides
    A M Tsatsakis
    Centre of Toxicology Sciences and Research, Medical School, University of Crete, Heraklion, Crete, Greece, Voutes, Heraklion, 71409 Crete, Greece
    Toxicol Lett 186:66-72. 2009
    Allelic variants of CYP1A1 and PON1 have been extensively studied as susceptibility factors in toxic response, although little is known about the role of these variants as risk factors for the plethora of diseases appearing in the human ..
  56. ncbi Paraoxonase-1 concentrations in end-stage renal disease patients increase after hemodialysis: correlation with low molecular AGE adduct clearance
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Vallejo, CA, USA, and Department of Internal Medicine, Showa University Northern Yokohama Hospital, Yokohama City, Japan
    Clin Chim Acta 377:213-20. 2007
    ..Reduced serum paraoxonase (PON-1) activity has been described in these patients, which could contribute to the accelerated development of ..
  57. pmc Racial differences in paraoxonase-1 (PON1): a factor in the health of southerners?
    Kimberly A Davis
    Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi 39762 6100, USA
    Environ Health Perspect 117:1226-31. 2009
    ..Paraoxonase-1 (PON1), an enzyme associated with high-density lipoprotein particles, participates both in the hydrolysis of oxidized ..
  58. ncbi Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study
    Bharti Mackness
    University Department of Medicine, Manchester Royal Infirmary, University of Manchester, Oxford Rd, Manchester M13 9WL, UK
    Circulation 107:2775-9. 2003
    The hypothesis that paraoxonase (PON1) has a role in preventing atherosclerosis is based on experimental, transgenic, and case-control studies but has not previously been tested prospectively.
  59. ncbi Paraoxonase 192 Gln-->Arg polymorphism: an independent risk factor for nonfatal arterial ischemic stroke among young adults
    Barbara Voetsch
    Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, Mass 02118, USA
    Stroke 33:1459-64. 2002
    ..Serum paraoxonase (PON1) is an HDL-associated esterase that hydrolyzes products of lipid peroxidation and prevents the oxidation of LDL...
  60. ncbi Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects
    Jintana Sirivarasai
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
    Chem Biol Interact 168:184-92. 2007
    Paraoxonase (PON1) plays an important role in mechanism of organophosphorus compound (OP) toxicity, as seen both in vitro and in vivo studies...
  61. pmc Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Hum Genet 72:13-22. 2003
    ..Three polymorphisms in the PON1 (Leu55Met and Gln192Arg) and PON2 (Ser311Cys) genes have been shown to be associated with the risk of CAD in ..
  62. pmc Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis
    Chunyu Liu
    Biogen Idec Inc, Cambridge, Massachusetts, USA
    Mol Med 14:575-81. 2008
    ..the type I interferon gene IFNk on chromosome 9; and in a locus on chromosome 7 that includes the paraoxonase I (PON1) gene...
  63. pmc Effects of intronic and exonic polymorphisms of paraoxonase 1 (PON1) gene on serum PON1 activity in a Korean population
    Sang Yong Eom
    Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Korea
    J Korean Med Sci 26:720-5. 2011
    Paraoxonase 1 (PON1) hydrolyzes a number of toxic organophosphorous compounds and reduces lipid peroxide accumulation, and PON1 genetic polymorphisms in the coding region modulate serum PON1 activity...
  64. doi Factors associated with paraoxonase genotypes and activity in a diverse, young, healthy population: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    Bharat Thyagarajan
    Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota Minneapolis, MN 55454, USA
    Clin Chem 54:738-46. 2008
    ..Paraoxonase may mitigate oxidative damage and thus lower risk of macrovascular disease...
  65. doi Association of genetic polymorphisms in the paraoxonase 1 gene with the risk and prognosis of non-small cell lung cancer in Chinese Han population
    Hui Wang
    Department of Oncology, Beijing Hospital, China Ministry of Health, Beijing, PR China
    J Investig Med 60:592-7. 2012
    ..Paraoxonase 1 (PON1) gene, encoding PON1 protein, plays an important role as an endogenous free-radical scavenging molecule...
  66. pmc Protective effect of R allele of PON1 gene on the coronary artery disease in the presence of specific genetic background
    Anna Balcerzyk
    Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medykow Str 18, 40 752 Katowice, Poland
    Dis Markers 24:81-8. 2008
    ..Participation of single polymorphic variants is relatively small, however its significance may increase in the presence of specific genetic or environmental background...
  67. ncbi Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification
    C E Furlong
    Department of Genetics, University of Washington, Seattle 98195
    Chem Biol Interact 87:35-48. 1993
    ..v. administration of partially purified rabbit paraoxonase protected animals against cholinesterase inhibition by paraoxon and chlorpyrifos oxon. Protection correlated with the relative rates of hydrolysis of these two compounds...
  68. doi Paraoxonase (PON1) and the risk for coronary heart disease and myocardial infarction in a general population of Dutch women
    Thomas M van Himbergen
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Atherosclerosis 199:408-14. 2008
    There is strong evidence from both animal- and in vitro-models that paraoxonase (PON1) is involved in the onset of cardiovascular disease...
  69. ncbi Paraoxonase phenotype distribution in a healthy Iranian population
    Farideh Sepahvand
    Institute of Biochemistry and Biophysics, Tehran University, Tehran, Iran
    Basic Clin Pharmacol Toxicol 101:104-7. 2007
    Human serum paraoxonase (PON1) is a high-density lipoprotein-associated esterase that protects against organophosphate neurotoxicity, and is proposed to play a role in lipid metabolism and the onset of cardiovascular disease...
  70. ncbi Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus
    Sachiyo Yamaguchi
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 19:631-7. 2007
    ..of type 2 diabetes mellitus in men, and that the A-->G (Arg160Gly) polymorphism of the paraoxonase 1 gene (PON1) was significantly associated with this condition in women...
  71. ncbi The molecular basis of the human serum paraoxonase activity polymorphism
    R Humbert
    Department of Genetics, University of Washington, Seattle 98195
    Nat Genet 3:73-6. 1993
    ..A genetic polymorphism of paraoxonase (PON) activity which determines high versus low paraoxon hydrolysis in human populations, may determine sensitivity to ..
  72. ncbi Association between PON 1 polymorphisms, PON activity and diabetes complications
    Sabine E Hofer
    Department of Endocrinology, The Children s Hospital at Westmead and University of Sydney, Sydney, Australia
    J Diabetes Complications 20:322-8. 2006
    The paraoxonase (PON) gene cluster maps to human chromosome 7q21-22. In the PON 1 gene, several polymorphisms in the promoter and coding regions have been identified and are known to influence gene expression levels...
  73. doi Monocyte chemoattractant protein-1 and paraoxonase-1 and 3 levels in patients with sepsis treated in an intensive care unit: a preliminary report
    Teresa Sans
    Laboratori d Anàlisis Clíniques, Hospital Verge de la Cinta, Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Tortosa, Spain
    Clin Chem Lab Med 50:1409-15. 2012
    ..Paraoxonases (PON) are antioxidant and anti-inflammatory enzymes that inhibit the production of the monocyte chemoattractant protein-..
  74. ncbi Paraoxonase (PON1) 55 and 192 polymorphism and its effects to oxidant-antioxidant system in turkish patients with type 2 diabetes mellitus
    B Agachan
    University of Istanbul, Institute for Experimental Medical Research, Department of Molecular Medicine, Istanbul, Turkey
    Physiol Res 54:287-93. 2005
    Paraoxonase (PON1) is a serum enzyme with an antioxidant function, protecting the low density lipoproteins (LDL) from oxidative modifications...
  75. ncbi Preferable stimulation of PON1 arylesterase activity by phosphatidylcholines with unsaturated acyl chains or oxidized acyl chains at sn-2 position
    Su Duy Nguyen
    College of Pharmacy, Chungnam National University, Yuseong Ku, Gung Dong, Taejon 305 764, Korea
    Biochim Biophys Acta 1758:499-508. 2006
    To examine the effect of phospholipids on PON1 activities, purified PON1 was exposed to phospholipids prior to the determination of arylesterase and paraoxonase activities...
  76. ncbi Interactions and associations of paraoxonase gene cluster polymorphisms with myocardial infarction in a Pakistani population
    M Saeed
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Clin Genet 71:238-44. 2007
    ..02) involving these three polymorphisms, suggesting a potential gene-gene interaction between PON1 and PON2. These polymorphisms also interacted with smoking, in a three-locus and a four-locus model (p = 0...
  77. doi Paraoxonase 1 (PON1) as a marker of short term death in breast cancer recurrence
    Christine Bobin-Dubigeon
    institut de cancérologie de l Ouest, Centre Rene Gauducheau, Nantes, France
    Clin Biochem 45:1503-5. 2012
    To relate paraoxonase (PON1) activity to survival time and short term death in breast cancer recurrence.
  78. doi PON gene polymorphisms and ischaemic stroke: a systematic review and meta analysis
    Hua Liu
    Department of Neurology, the Second Clinical Medical College of North Sichuan Medical College, Nanchong, China
    Int J Stroke 8:111-23. 2013
    ....
  79. ncbi Paraoxonase 1 polymorphisms as the risk factor of coronary heart disease in a Thai population
    Atip Likidlilid
    Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Acta Cardiol 65:681-91. 2010
    Two common polymorphisms of the paraoxonase (PON1) gene, L55M and Q192R, were proven to mitigate atherosclerosis pathogenesis by protecting lipoproteins against peroxidation...
  80. ncbi Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates
    Lucio G Costa
    Department of Environmental Health, University of Washington, Seattle, Washington 98105 6099, USA
    J Toxicol Clin Toxicol 41:37-45. 2003
    Paraoxonase (PON1) is an HDL-associated enzyme capable of hydrolyzing multiple substrates, including several organophosphorous insecticides and nerve agents, oxidized lipids, and a number of drugs or pro-drugs...
  81. ncbi Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II
    Kirsty S Robertson
    Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College Medical School, 5 University St, London WC1E 6JF, UK
    Biochim Biophys Acta 1639:203-12. 2003
    ..Three distinct enzymes have been identified, encoded by PON1, PON2 and PON3, clustered on chromosome 7q21-q22...
  82. doi Effect of non-genetic factors on paraoxonase 1 activity in patients undergoing hemodialysis
    Marija Grdić Rajković
    Department of Medical Biochemistry and Hematology, University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
    Clin Biochem 43:1375-80. 2010
    Hemodialyzed patients have lower paraoxonase 1 (PON1) activity. Higher mortality risk from cardiovascular disease observed in these patients could be due to the low antiathetrogenic activity of PON1...
  83. ncbi PON1 M/L55 mutation protects high-risk patients against coronary artery disease
    Simone A Oliveira
    Hematology Center, University of Campinas, Sao Paulo, Brazil
    Int J Cardiol 94:73-7. 2004
    The paraoxonase (PON) gene family contains at least three members: PON1, PON2, and PON3. The enzyme PON1 has been implicated in the pathogenesis of atherosclerosis...
  84. ncbi Paraoxonase and susceptibility to organophosphorus poisoning in farmers dipping sheep
    Bharti Mackness
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Pharmacogenetics 13:81-8. 2003
    Human serum paraoxonase (PON1) hydrolyses organophosphate pesticides (OPs) entering the blood circulation and tissue fluid thus limiting toxicity...
  85. doi Paraoxonase 1 gene polymorphisms contribute to coronary artery disease risk among north Indians
    S Agrawal
    Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Indian J Med Sci 63:335-44. 2009
    Polymorphisms in paraoxonase 1 (PON1) coding for PON1 enzyme have been studied as genetic markers of coronary artery disease (CAD)...
  86. pmc Protective effect of paraoxonase 1 gene variant Gln192Arg in age-related macular degeneration
    Gayle J T Pauer
    Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Am J Ophthalmol 149:513-22. 2010
    ..Paraoxonase 1 (PON1) protects against oxidative damage and has been evaluated for its involvement in aging diseases including AMD...
  87. doi Paraoxonase gene polymorphisms and stroke severity
    L Lazaros
    Laboratory of Medical Genetics, Universit of Ioannina, Ioannina, Greece
    Eur J Neurol 17:757-9. 2010
    Paraoxonase (PON) is an HDL-associated enzyme that prevents low-density lipoprotein oxidation, playing a major role in the pathogenesis of atherosclerosis. PON genes polymorphisms may affect the corresponding enzyme activity...
  88. doi Main determinants of PON1 activity in hemodialysis patients
    Sandra Ribeiro
    Faculdade de Farmacia, Serviço de Bioquímica, Portugal
    Am J Nephrol 36:317-23. 2012
    ..These patients present reduced paraoxonase 1 (PON1) activity that depends on genetic and non-genetic factors; however, how these factors influence PON1 activity in HD ..
  89. ncbi Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians
    Massimiliano Bonafe
    Department of Experimental Pathology, Bologna University, Bologna, Italy
    Eur J Hum Genet 10:292-6. 2002
    Human Paraoxonase (PON1) is a High-Density Lipoprotein (HDL)-associated esterase that hydrolyses lipo-peroxides...
  90. ncbi Pharmacogenomic considerations of the paraoxonase polymorphisms
    Clement E Furlong
    Department of genome Services, University of Washington, Seattle, WA 98195, USA
    Pharmacogenomics 3:341-8. 2002
    The high density lipoprotein (HDL)-associated enzyme paraoxonase-1 (PON1) exhibits a substrate-dependent activity polymorphism as well as a large variability in plasma levels among individuals...
  91. doi Relationship between Paraoxonase 1 (PON1) gene polymorphisms and susceptibility of stroke: a meta-analysis
    Indranil Banerjee
    Institute of Biochemistry, Swiss Federal Institute of Technology ETH, HPM E10 1, Schafmattstrasse 18, 8093, Zurich, Switzerland
    Eur J Epidemiol 25:449-58. 2010
    Genetic variants of paraoxonase 1 (PON1) were implicated in stroke susceptibility in several case-control association studies...
  92. ncbi Lack of association between the paraoxonase 1 Q/R192 single nucleotide polymorphism and stroke in a Chinese cohort
    Z J Xiao
    Department of Neurology, Second Xiangya Hospital of Central South University, Changsha, China
    Acta Neurol Belg 109:205-9. 2009
    Serum paraoxonase (PON1) is an HDL-associated esterase that hydrolyzes products of lipid peroxidation and prevents the oxidation of LDL. Paraoxonase 1 (PON1) was implicated in susceptibility to stroke in previous studies...
  93. ncbi Human serum paraoxonase gene polymorphisms, Q192R and L55M, are not associated with the risk of cerebral infarction in Chinese Han population
    Qing Huang
    Institute of Neurology, Xiangya Hospital of Central South University, Changsha 410008, China
    Neurol Res 28:549-54. 2006
    It has been reported that human serum paraoxonase (PON1) gene is associated with coronary heart disease (CHD) and diabetes mellitus (DM). However, little is known about the role of PON1 gene polymorphism in cerebral infarction (CI)...
  94. ncbi Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations
    I Leviev
    Clinical Diabetes Unit, Division of Endocrinology and Diabetology, University Hospital, Geneva, Switzerland
    Arterioscler Thromb Vasc Biol 20:516-21. 2000
    ..The present study has identified 3 polymorphisms in the promoter region of the human PON1 gene...
  95. pmc Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery disease
    Nicola Martinelli
    Department of Medicine, University of Verona, Policlinico G B Rossi, Italy
    Exp Diabetes Res 2012:231502. 2012
    ..The antioxidant ability of HDLs is, at least in part, attributable to pleiotropic serum paraoxonase (PON1)...
  96. pmc Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression
    V H Brophy
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 68:1428-36. 2001
    Human HDL-associated paraoxonase (PON1) hydrolyzes a number of toxic organophosphorous compounds and reduces oxidation of LDLs and HDLs...
  97. ncbi Impact of paraoxonase polymorphism (Q192R) on endothelial function in intact coronary circulation
    Tetsunobu Yamane
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Hypertens Res 29:417-22. 2006
    Paraoxonase-1 (PON1) can protect endothelial function by preventing the oxidation of low-density lipoprotein (LDL) cholesterol and retarding the development of atherosclerosis...
  98. ncbi Interaction of paraoxonase-192 polymorphism with low HDL-cholesterol in coronary artery disease risk
    Maria Isabel Mendonça
    Unidade de Investigação e Serviço de Cardiologia do Hospital Dr Nélio Mendonça Hospital Central do Funchal, Funchal, Madeira, Portugal
    Rev Port Cardiol 29:571-80. 2010
    ..Increased lipid peroxidation is associated with accelerated progression of atherosclerosis. Paraoxonase (PON1) is an antioxidant enzyme bound to high-density lipoprotein (HDL), which protects against lipid peroxidation and ..
  99. ncbi Xenobiotic gene polymorphisms and susceptibility to multiple myeloma
    Lisa F Lincz
    Haematologica 89:628-9. 2004
    ..In a case-control study, 90 Australian Caucasians with MM had significantly higher incidences of GST T1 null, PON1 BB and NAT2 slow acetylation genotypes, but no difference in polymorphism frequencies for GST M1, NAT1, and CYP1A1 ..
  100. ncbi Paraoxonase gene polymorphism and vitamin levels during pregnancy: Relationship with maternal oxidative stress and neonatal birthweights
    Jungwon Min
    Department of Preventive Medicine, Ewha Womans University, Seoul, South Korea
    Reprod Toxicol 22:418-24. 2006
    ..association between maternal oxidative stress and adverse birth outcome, and serum vitamin levels and paraoxonase (PON) polymorphism during pregnancy...
  101. ncbi PON1 L55M polymorphism is not a predictor of coronary atherosclerosis either alone or in combination with Q192R polymorphism in an Italian population
    M Arca
    Universita degli Studi di Roma La Sapienza, Rome, Italy
    Eur J Clin Invest 32:9-15. 2002
    The present study evaluated the role of the PON1 L55M polymorphism independently and in conjunction with the Q192R polymorphism on the risk of coronary atherosclerosis in an Italian population.

Research Grants62

  1. Novel mechanisms by which aspirin might protect against atherosclerosis
    Sampath Parthasarathy; Fiscal Year: 2012
    ..Hydrolysis was competed for by substrates of "aryl esterases" that prompted us to propose that paraoxonase 1 (PON 1) type of enzymes might be involved in the metabolism of aspirin...
  2. Relationship of Blood Esterases, Pesticide Exposure and Cardiovascular Disease
    Janice Chambers; Fiscal Year: 2009
    ..we have studied for many years because of their involvement in the detoxication of many pesticides are paraoxonase (PON1) and carboxylesterase (CaE)...
  3. Multicenter ALS Cohort Study of Oxidative Stress and Disease Progression
    Hiroshi Mitsumoto; Fiscal Year: 2013
    ..will obtain measures of OS biomarkers (urinary 15-F2t-isoprostane and 8- oxodeoxyguanosine, plasma paraoxonase I [PON1] levels, and PON1 functional status) and, through structured interviews, measures of current environmental, ..
  4. Pesticides, Paraoxonase and Alzheimer's Disease
    Mark S Kindy; Fiscal Year: 2010
    ..Specific Aim 3: To study the therapeutic effects of galantamine and adenoviral delivered PON1 on organophosphate provoked AD...
  5. Moving Beyond HDL Cholesterol, HDL Function as a Coronary Disease Biomarker
    ANAND KUMAR ROHATGI; Fiscal Year: 2013
    ..influencing variation n HDL functions across a diverse population;2) determine the associations of paraoxonase-1 (PON-1) activity and genotype with HDL functions;3) comprehensively investigate the role of HDL functions in predicting ..
  6. Biophysics of HDL Dysfunction
    Mary G Sorci-Thomas; Fiscal Year: 2013
    ..which oxidation impacts on the ability of HDL to interact with 1) anti- and pro-inflammatory enzymes (paraoxonase [PON1], platelet activating factor acetylhydrolase [PAF-AH], myeloperoxidase [MPO] and xanthine oxidase [XO]) to prevent ..
  7. The Rosetta Enzyme ReDesign: Targeting PON1 as OP Scavenger
    Jennifer M Bui; Fiscal Year: 2012
    ..In this context, human serum paraoxonase, PON1 could become a promising scavenger against highly toxic OP compounds because 1) it is in human serum, 2) it can ..
  8. Role of High Density Lipoprotein Particles in amyotrophic lateral sclerosis
    Teepu Siddique; Fiscal Year: 2012
    ..Further studies of the paraoxonase enzymes PON1 and PON3 in the plasma indicate that their levels are significantly elevated in SALS patients, although the ..
  9. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2009
    ..P1 (GSTP1), NAD(P)H:quinone oxidoreductase (NQ01), catechol-O-methyl transferase (COMT), paraoxonase 1 (PON1), heme oxygenase (HO1), and peroxisome proliferator activated receptor gamma (PPARg), in colorectal cancer ..
  10. Exploring Gene-Environment Factors in Child Brain Tumors
    Beth Mueller; Fiscal Year: 2004
    ..3) Microsomal epoxide hydrolase, relevant to activation of PAHs into cancer-causing intermediates; 4) Paraoxonase (PON1), potentially important in detoxifying metabolites of the common organophosphate (OP) insecticides chlorpyrifos and ..
  11. ACTION OF ALCOHOL & QUERCETIN ON ANTI-ATHEROGENIC FACTORS & ATHEROGENESIS
    Raj Lakshman; Fiscal Year: 2007
    ..In contrast, HDL protects against atherosclerosis via its enzyme paraoxonase (PON) that destroys OxLDL...
  12. PRESERVATION OF HDL FUNCTION DURING EARLY ATHEROGENESIS
    JOHN BIELICKI; Fiscal Year: 2002
    ..the underlying mechanism of LCAT impairment, and 3) establish whether the HDL-associated enzyme, paraoxonase (PON), can protect LCAT activity from specific molecular species of lipid peroxides...
  13. PON1 and Developmental Sensitivity to OP Pesticides
    Nina T Holland; Fiscal Year: 2010
    ..For example, the human enzyme paraoxonase (PON1) detoxifies various OPs with different efficiency depending on the main polymorphism at position 192 and others ..
  14. GENETIC EPIDEMIOLOGY OF LIPOPROTEIN/LIPID LEVELS
    M Kamboh; Fiscal Year: 2000
    ..methyl glutryl-coenzyme A (HMG COA), VLDL-receptor, Lecithin cholesterol acyletransferase (LCAT) and paraoxonase (PON)] in determining quantitative lipoprotein-lipid levels in Hispanics and non-Hispanic Whites of the San Luis Valley, ..
  15. Targeted Paraoxonase Fusion Protein as a Neurotherapeutic for Nerve Gas Agents
    RUBEN BOADO; Fiscal Year: 2009
    ..The most active OP hydrolase in human blood is paraoxonase (PON)-1. However, PON-1 does not cross the BBB...
  16. INTIMAL THICKENING & ANTITOXIDANTS IN HISPANICS & ANGLOS
    James Dwyer; Fiscal Year: 2003
    ..with IMT was enhanced by higher plasma, beta-cryptoxanthin and by increased plasma level of an enzyme (paraoxonase, PON) that destroys oxidized lipids...
  17. Genetic & Structure-Function Studies: Paraoxonase In SLE
    M Kamboh; Fiscal Year: 2006
    ..Three PON genes, PON1, PON2 and PON3 are linked on chromosome 7...
  18. Enhancement of Medullary Erythropoiesis during Anemia by Trib3
    David Kuhrt; Fiscal Year: 2013
    ..In Trib3-KO mice, I have found that steady state erythropoiesis is unperturbed, but during anemia or ESA administration stress erythropoiesis in bone marrow is compromised...
  19. The human glucocorticoid receptor and normal and pathological terminal erythroid
    Anna Rita F Migliaccio; Fiscal Year: 2013
    ..DXM is used as erythropoiesis stimulating agent (ESA) to rescue the deficient terminal erythroid (EB) maturation observed in patients with Diamond Blackfan Anemia (DBA),..
  20. Computational Approach to Personalized Anemia Management
    Adam E Gaweda; Fiscal Year: 2013
    ..Evidence shows that excessive doses of Erythropoiesis Stimulating Agents (ESA), used in hypo-responsive patients, coincide with increased cardiovascular complications...
  21. Hepcidin and Anemia in Children: Mechanisms and Modifiers
    MEREDITH ANN ATKINSON; Fiscal Year: 2013
    ..Anemia which does not respond to treatment with erythropoiesis stimulating agents (ESA) is common in clinical practice...
  22. Do Safety Warnings Change Prescribing among the US Dialysis Population?
    Mae Thamer; Fiscal Year: 2012
    ..a Black Box Warning that went out to all practicing nephrologists) indicating the safety risks associated with ESA therapy and recommendations to use 'the lowest dose possible to avoid blood transfusions'resulted in a ..
  23. Comparative Effectiveness and Safety of Newer Agents for Anemia Treatment in HD
    WOLFGANG CHRISTOPH WINKELMAYER; Fiscal Year: 2013
    ..based on patient characteristics, we can exploit natural experiments that occur when facilities switch their ESA or iron agent for their entire patient population...
  24. PACTTE-Partnership for Anemia: Clinical and Translational Trials in the Elderly
    Harvey Jay Cohen; Fiscal Year: 2012
    ..Our initial protocol will consist of a randomized treatment trial of (ESA) or placebo among UAE patients 70 years and older...
  25. Comparative Effectiveness: Erythropoietic Stimulating Agents in Treatment of MDS
    Amy J Davidoff; Fiscal Year: 2010
    ..This study will examine patterns of treatment with erythropoietic stimulating agents (ESA) in patients with myelodysplastic syndromes (MDS), and compare clinical benefits, risks, and costs associated with ..
  26. The Engineering of Individualized Anemia Management Protocols
    Yossi Chait; Fiscal Year: 2013
    ..Increased use of ESA's has also led to recognition of their limitations by virtue of observed adverse events...
  27. Erythropoiesis-stimulating agent use among chronic kidney disease patients
    DENNIS JOSEPH COTTER; Fiscal Year: 2012
    ..Erythropoiesis-stimulating agents (ESA therapy) - approved in 1989 for use among the renal disease population - is used to correct anemia...
  28. ESA Outcomes among Anemic CKD Patients
    DENNIS JOSEPH COTTER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): ESA Outcomes Among Anemic CKD Patients Background. There has been a 30% increase in chronic kidney disease (CKD) over the past decade...
  29. Brain imaging and developmental follow-up of infants treated with erythropoietin
    Robin K Ohls; Fiscal Year: 2013
    ..intervention is the use of recombinant erythropoietin (Epo, also known as an erythropoiesis stimulating agent, or ESA)...
  30. The role of PON2 and PON3 proteins in Atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2013
    ..PON), a family of orphan enzymes with multiple enzyme activities assigned to them, comprise of three proteins PON1, PON2, and PON3...
  31. ENVIRONMENTAL/GENETIC RISK FACTORS FOR PARKINSON'S
    Jordan Firestone; Fiscal Year: 2004
    ..will be analyzed for genetic polymorphisms related to dopamine and xenobiotic metabolism (MAO- B, CYP-2D6 and 2E1, PON1, and GST isoenzymes Ml, T1, and P1)...
  32. Prevalence of CD24 epigenetic silencing in breast tumors and ERalpha status
    Benny Abraham Kaipparettu; Fiscal Year: 2012
    ..Interestingly, epithelial cells with the CD44 positive CD24 low/absent marker combination (ESA????/low) are considered putative BCSCs...
  33. Testing of novel anti-cancer compounds Curaxins against pancreatic cancer
    Katerina Gurova; Fiscal Year: 2013
    ..into pancreatic cancer stem cells (PCSC) and bulk PDA cells based on expression of PCSC markers (CD24, CD44 and ESA). The CX concentration killing the majority of cells (LC90) will be determined for each cell sample...
  34. Prenatal Exposures & Procarcinogenic Mutations
    Manuela Orjuela; Fiscal Year: 2007
    ..Other studies indicate that polymorphisms in the PON1 gene involved in the detoxification of organophosphates are also likely to affect the development of chromosomal ..
  35. Formulation and Encapsulation of Enzymic Countermeasures Against Organophosphorus
    Thomas J Magliery; Fiscal Year: 2013
    ..has been recent progress in the development of catalytic bioscavengers, such as engineered mutants of paraoxoase-1 (PON1), particularly against G-agents. Through a CounterACT U54 grant that is a collaboration among the U.S...
  36. Envronment-Sensitive genes in motoneuron degeneration
    Teepu Siddique; Fiscal Year: 2010
    ..The PON cluster of genes (PON1, 2 and 3) was associated with SALS and this finding has been validated in four other studies...
  37. Vulnerability of the Adolescent Brain to Organophosphorus Pesticides
    Diane S Rohlman; Fiscal Year: 2013
    ..pyrethroid) and functional polymorphisms in key enzymes involved in OP metabolism (CYP2B6, CYP2C19, and PON1) as modifiers of bioeffective dose...
  38. Inner City Toxicants, Child Growth and Development
    Mary Wolff; Fiscal Year: 2009
    ..susceptibility to EDs by identifying and characterizing polymorphisms and variations in expression levels of PON1, lipase, and UGT-glucuronyltransferase enzymes involved in ED metabolism...
  39. Structure and Function of the Human PON1 Polymorphism
    Clement E Furlong; Fiscal Year: 2013
    ..of the proposed research is to understand the physiological consequences of genetic variability in the human PON1 gene and to identify factors that contribute to the large differences in plasma PON1 levels among individuals...
  40. rTMS for the Treatment of Chronic Pain in GW1 Veterans
    John Wesson Ashford; Fiscal Year: 2013
    ..Also, genetic data will be gathered for a pilot sub-study analysis that examines the PON1 gene relationship with GWI symptomatology To determine whether repetitive Transcranial Magnetic Stimulation (rTMS) ..
  41. Inhibition of Cancer stem cell characterisitcs in Pancreatic Cancer
    Sharmila Shankar; Fiscal Year: 2013
    ..We have recently demonstrated that human CD133+CD44+CD24+ESA+ CSCs express Nanog, Notch-1 and Oct-4 and are highly tumorigenic in mice...
  42. DETECTION OF BIOMOLECULES BY CHEMILUMINESCENCE
    NEIL DANIELSON; Fiscal Year: 1990
    ..start-up and more versatile operation, we plan to do on- line oxidation of Ru(bpy)3+2 to Ru(byp)3+3 using the ESA coulometric flow cell...
  43. ESA, a Novel Anti-inflammation Agent
    PETER RECZEK; Fiscal Year: 2009
    ..We have recently discovered that Esculentoside A (EsA), a saponin isolated from Phytolacca esculenta, has multifactorial anti-inflammatory activity and specifically ..
  44. Prenatal Toxicant Exposure and Risk of Attention-Deficit Hyperactivity Disorder
    Stephanie M Engel; Fiscal Year: 2013
    ..modification of the organophosphate-ADHD relation by functional gene variants in a key metabolism enzyme, PON1, will be examined...
  45. Elastic Shape Analysis for Protein Structure Alignment-New Advancement in an Old
    Jinfeng Zhang; Fiscal Year: 2013
    ..In this proposal, we develop methods based on elastic shape analysis (ESA) for protein structure comparison and alignment...
  46. Predictors of Adult Leukemia
    Julie Ross; Fiscal Year: 2009
    ..with adult leukemia, c) obesity as a risk factor, and d) the role of genetic susceptibility genes including PON1, CYPs (2C9,3A4,2E1,2D6), GSTs (M1/T1), UGT1A6, PLA2, ODC, MDR1, MPO, NQ01, LEPR, and LEP...
  47. Enhanced endothelialization for tissue engineering
    Kytai Nguyen; Fiscal Year: 2006
    ..onto PLLA surfaces using different immobilized techniques: coating, cross-linking, and electrostatic self-assembly (ESA)...
  48. Discovery of a Selective Agent that Activates PON1 Enzymatic Activity
    John Scott; Fiscal Year: 2009
    ..Therefore, finding new and more effective anti-atherogenic therapies is critical to saving many lives. PON1 is a serum enzyme that has been implicated in playing a protective role against development of atherosclerosis...
  49. Discovery of a Selective Agent that Activates PON1 Enzymatic Activity
    John Scott; Fiscal Year: 2007
    ..Therefore, finding new and more effective anti-atherogenic therapies is critical to saving many lives. PON1 is a serum enzyme that has been implicated in playing a protective role against development of atherosclerosis...
  50. Hyperbaric oxygen and atherosclerosis
    Ladislav Dory; Fiscal Year: 2007
    ..These changes are accompanied by significant increases in the expression of antioxidant enzymes (ecSOD, Mn-SOD, PON1) in the liver, peritoneal macrophages (ecSOD and GPX3) and the aortic tissue (ecSOD and GPX3)...
  51. LEARNING THROUGH ENVIRONMENTAL HEALTH SCIENCE SCENARIOS
    Nancy Kerkvliet; Fiscal Year: 2006
    ..Challenge Problems, an existing set of environmental health science scenarios, developed under NIEHS grant ESA-96-001, to improve the critical-thinking skills of high school students and to engage them in developing solutions ..
  52. METHODS FOR KYNURENINE SYSTEM IN HUNTINGTON'S DISEASE
    Wayne Matson; Fiscal Year: 1990
    ..multiparameter measurements and the procedures for rapid data reduction, transfer and management developed for the ESA Neurochemical Analyzer (NCA)...
  53. BIOMEDICAL RESEARCH AT THE UNIVERSITY OF GUAM
    Peter J Schupp; Fiscal Year: 2010
    ..Upon reestablishment of the SCORE program, the PIs and proposed External Scientific Advisor (ESA) will mentor other faculty in establishing their own research programs...
  54. PATHOBIOLOGY OF GI INFECTION AND INFLAMATION
    Michael Gershon; Fiscal Year: 2005
    ..Luan (HIV-1 replication & pathogenesis); A. Mitchell (infection by the fungus, Candida albicans); L. Pon (actin cytoskeletal control of membrane trafficking & enterobacterial infection); A...
  55. ESA, a Novel Anti-inflammation Agent
    Lurong Zhang; Fiscal Year: 2005
    We have discovered that Esculentoside A (EsA) has potent anti-inflammatory effects including specific COX2 inhibition...
  56. Genes, OP Pesticides, and Reproductive Health
    Scott Venners; Fiscal Year: 2007
    ..candidate genes relevant both to metabolism of organophosphate pesticide and endocrine function including: CYP3A4, PON1, PON2, PON3, GSTM1, BCHE, ESR1, GnRHR LHCGR, and FSHR. Dr...
  57. Modulators of HDL structure-function
    G Anantharamaiah; Fiscal Year: 2007
    ..This occurs via the formation of preD-HDL-like particles that possess increased paroxonase-1 (PON1) activity which are able to destroy lipid hydroperoxides (LOOH) and enhance reverse cholesterol transport, the ..
  58. NEURONS AND CIRCUITS OF PERIOLIVARY NUCLEI
    ALBERT BERREBI; Fiscal Year: 1999
    ..principal nuclei are surrounded by a sphere of accessory cell groups, collectively known as periolivary nuclei (PON)...
  59. CHILD AND FAMILY THERAPY FOR ANXIETY-DISORDERED YOUTH
    PHILIP KENDALL; Fiscal Year: 2004
    ..ICBT), 50 cases to Family Cognitive-Behavioral Therapy (FCBT), and 50 cases to an education/support/attention (ESA) control condition. All conditions will be 16 sessions...
  60. NATURAL INHIBITOR OF INFLAMMATORY CASCADE
    Susan Wright; Fiscal Year: 1999
    ..We have identified a unique compound, EsA, derived from the roots of a Chinese medicinal herb that inhibits generation of multiple mediators of the ..
  61. Inflammatory Genomics in Human Carotid Artery Disease
    GAIL JARVIK; Fiscal Year: 2006
    ..Genes that are implicated in disease may eventually allow targeted therapy. ..