Genomes and Genes
Gene Symbol: POLR3A
Description: polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Alias: ADDH, HLD7, RPC1, RPC155, hRPC155, DNA-directed RNA polymerase III largest subunit, DNA-directed RNA polymerase III subunit A, DNA-directed RNA polymerase III subunit RPC1, RNA polymerase III 155 kDa subunit, RNA polymerase III subunit C1, RNA polymerase III subunit C160, RNA polymerase III subunit RPC155-D
- The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIICK L Jang
Department of Biochemistry, University College and Middlesex School of Medicine, London, U K
J Acquir Immune Defic Syndr 5:1142-7. 1992..The significance of this effect for the life cycle of HIV and its interaction with infected cells is discussed...
- Ancient origin, functional conservation and fast evolution of DNA-dependent RNA polymerase IIIGalina M Proshkina
Laboratory of Mechanisms of Gene Expression, Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia
Nucleic Acids Res 34:3615-24. 2006..Ten core subunits showed heterospecific complementation, but the two largest catalytic subunits (Rpc1 and Rpc2) and all five RNA polymerase III-specific subunits (Rpc82, Rpc53, Rpc37, Rpc34 and Rpc31) were non-..
- Characterization of the RNA polymerase II and III complexes in Leishmania majorSANTIAGO MARTINEZ CALVILLO
Seattle Biomedical Research Institute, 307 Westlake Avenue N, Seattle, WA 98109 5219, USA
Int J Parasitol 37:491-502. 2007..0890) of the two LmRPB6 orthologues. The latter experiments also identified the RNAP III subunits RPC1 (C160), RPC2 (C128), RPC3 (C82), RPC4 (C53), RPC5 (C37), RPC6 (C34), RPC9 (C17), RPAC1 (AC40) and RPAC2 (AC19)...
- BRCA1 ubiquitinates RPB8 in response to DNA damageWenWen Wu
Division of Breast and Endocrine Surgery, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki 216 8511, Japan
Cancer Res 67:951-8. 2007..Our findings suggest that ubiquitination of a common subunit of RNA polymerases is a mechanism underlying BRCA1-dependent cell survival after DNA damage...
- A sequence predicted to form a stem-loop is proposed to be required for formation of an RNA-protein complex involving the 3'UTR of beta-subunit F0F1-ATPase mRNATatiana V Kramarova
The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
Biochim Biophys Acta 1777:747-57. 2008..Using electrophoretic mobility shift assays we found that two major RNA-protein complexes (here called RPC1 and RPC2) were formed with the full-length 3'UTR...
- The Carboxyl-terminal Domain of RNA Polymerase II Is Not Sufficient to Enhance the Efficiency of Pre-mRNA Capping or Splicing in the Context of a Different PolymeraseBarbara J Natalizio
Department of Molecular Genetics and Microbiology, Center for RNA Biology, and Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 284:8692-702. 2009..Our results indicate that the CTD fused to the largest subunit of RNAP III (POLR3A) is not sufficient to enhance co-transcriptional pre-mRNA splicing or capping in vivo...
- RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediateAndrea Ablasser
Institute for Clinical Chemistry and Pharmacology, University of Bonn, Bonn, Germany
Nat Immunol 10:1065-72. 2009..This pathway was important in the sensing of Epstein-Barr virus-encoded small RNAs, which were transcribed by RNA polymerase III and then triggered RIG-I activation. Thus, RNA polymerase III and RIG-I are pivotal in sensing viral DNA...
- Mutations of POLR3A encoding a catalytic subunit of RNA polymerase Pol III cause a recessive hypomyelinating leukodystrophyGenevieve Bernard
Departments of Pediatrics, Neurology and Neurosurgery, Division of Pediatric Neurology, Montreal Children s Hospital, McGill University Heath Center, Montreal, Quebec, Canada
Am J Hum Genet 89:415-23. 2011..Two missense and one insertion mutations in five individuals with TACH were uncovered in POLR3A, which codes for the largest subunit of RNA polymerase III (Pol III)...
- Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathyHirotomo Saitsu
Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
Am J Hum Genet 89:644-51. 2011..We also identified compound heterozygous missense mutations in POLR3A in the remaining individual...
- Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunitsPing Hu
Graduate Program of Molecular and Cellular Biology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
Mol Cell Biol 22:8044-55. 2002..Our results provide a characterization of human RNA polymerase III and show that the RPC5 subunit is essential for transcription...
- Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assayMasataka Kuwana
Institute for Advanced Medical Research, Keio University School of Medicine, 55 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Arthritis Rheum 46:2742-7. 2002..To characterize an immunodominant epitope on RNA polymerase III (RNAP III) recognized by systemic sclerosis (SSc) sera and to develop an enzyme-linked immunosorbent assay (ELISA) for the detection of serum anti-RNAP I/III antibodies...
- Development of RNA polymerase-promoter contacts during open complex formationJ Mecsas
Department of Bacteriology, University of Wisconsin Madison 53706
J Mol Biol 220:585-97. 1991..E sigma 32 initially anchors itself in the upstream region of the promoter forming the first closed complex, RPC1; in this complex the enzyme makes backbone contacts in the -35 region of the promoter that are maintained ..
- Intermediates in the formation of the open complex by RNA polymerase holoenzyme containing the sigma factor sigma 32 at the groE promoterD W Cowing
Department of Bacteriology, University of Wisconsin Madison 53706
J Mol Biol 210:521-30. 1989..the groE promoter involves three classes of steps: E sigma 32 initially binds to the promoter in a closed complex (RPC1) in which the enzyme interacts with a smaller region of the DNA than in the open complex...
- Identification of the gene coding for the largest subunit of RNA polymerase I (A) of Drosophila melanogasterS Knackmuss
Institute of Molecular Genetics, University of Heidelberg, Germany
Mol Gen Genet 253:529-34. 1997..RPA1 subunits of Drosophila melanogaster and lower eukaryotes share an additional Zn-binding motif at the N-terminus with archaebacterial and RPC1 subunits, testifying to the complex evolutionary relationships among the RNA polymerases.
- DNA sequencing and analysis of 130 kb from yeast chromosome XVH Voss
Biochemical Instrumentation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
Yeast 13:655-72. 1997..yeast genes (36% of all ORFs in this fragment) were nucleoporin (NUP1), ras protein (RAS1), RNA polymerase III (RPC1) and elongation factor 2 (EF2)...
- The largest subunit of human RNA polymerase III is closely related to the largest subunit of yeast and trypanosome RNA polymerase IIIS Sepehri
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Genome Res 7:1006-19. 1997....
- Sequence divergence of the RNA polymerase shared subunit ABC14.5 (Rpb8) selectively affects RNA polymerase III assembly in Saccharomyces cerevisiaeA Voutsina
Foundation for Research and Technology Hellas, Institute of Molecular Biology and Biotechnology and Department of Biology, University of Crete, PO Box 1527, Heraklion 711 10 Crete, Greece
Nucleic Acids Res 27:1047-55. 1999..cerevisiae. Overexpression of the S.cerevisiae largest subunit of RNA polymerase III C160 (Rpc1) allows S.pombe rpb8 to functionally replace ABC14.5 in S...
- Construction of a high-resolution physical map of the chromosome 10q22-q23 dilated cardiomyopathy locus and analysis of candidate genesK R Bowles
Department of Molecular and Human Genetics, Department of Pediatrics Cardiology, Department of Medicine, Department of Cardiovascular Sciences, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Genomics 67:109-27. 2000..9 Mb long). Seven genes, including ANX11, PPIF, DLG5, RPC155, RPS24, SFTPA1, and KCNMA1, have been mapped to the region of interest...
- Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2C Mertens
Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 98:7795-800. 2001..existence of two nuclear particles containing plakophilin 2 and the largest subunit of RNA polymerase (pol) III (RPC155), both of which colocalize and are coimmunoselected with other pol III subunits and with the transcription factor ..
- Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophyMartine Tetreault
Neurogenetics of Motion Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
Am J Hum Genet 89:652-5. 2011Mutations in POLR3A encoding the largest subunit of RNA polymerase III (Pol III) were found to be responsible for the majority of cases presenting with three clinically overlapping hypomyelinating leukodystrophy phenotypes...