POLH

Summary

Gene Symbol: POLH
Description: DNA polymerase eta
Alias: RAD30, RAD30A, XP-V, XPV, DNA polymerase eta, RAD30 homolog A, polymerase (DNA directed), eta, polymerase (DNA) eta, xeroderma pigmentosum variant type protein
Species: human
Products:     POLH

Top Publications

  1. Inui H, Oh K, Nadem C, Ueda T, Khan S, Metin A, et al. Xeroderma pigmentosum-variant patients from America, Europe, and Asia. J Invest Dermatol. 2008;128:2055-68 pubmed publisher
    ..normal nucleotide excision repair, but have defects in the POLH gene encoding an error-prone polymerase, DNA polymerase eta (pol eta)...
  2. Yamada A, Masutani C, Iwai S, Hanaoka F. Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta. Nucleic Acids Res. 2000;28:2473-80 pubmed publisher
    ..XPV encodes DNA polymerase eta, a novel DNA polymerase that belongs to the UmuC/DinB/Rad30 superfamily...
  3. Plosky B, Vidal A, Fernández de Henestrosa A, McLenigan M, McDonald J, Mead S, et al. Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin. EMBO J. 2006;25:2847-55 pubmed
  4. Barkley L, Palle K, Durando M, Day T, Gurkar A, Kakusho N, et al. c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks. Mol Biol Cell. 2012;23:1943-54 pubmed publisher
    ..Rad18 S409A also failed to fully complement the UV sensitivity of Rad18-depleted cells. Taken together, these results show that Rad18 phosphorylation by JNK represents a novel mechanism for promoting TLS and DNA damage tolerance. ..
  5. Pozhidaeva A, Pustovalova Y, D Souza S, Bezsonova I, Walker G, Korzhnev D. NMR structure and dynamics of the C-terminal domain from human Rev1 and its complex with Rev1 interacting region of DNA polymerase η. Biochemistry. 2012;51:5506-20 pubmed
    ..These results offer new insights into the control of TLS in human cells by providing a structural basis for understanding the recognition of the Rev1-CT by Y-family DNA polymerases. ..
  6. Akagi J, Masutani C, Kataoka Y, Kan T, Ohashi E, Mori T, et al. Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells. DNA Repair (Amst). 2009;8:585-99 pubmed publisher
    ..Thus, Poleta-REV1 interactions prevent spontaneous mutations, probably by promoting accurate TLS past endogenous DNA lesions, while the interaction is dispensable for accurate Poleta-mediated TLS of UV-induced lesions. ..
  7. Stary A, Kannouche P, Lehmann A, Sarasin A. Role of DNA polymerase eta in the UV mutation spectrum in human cells. J Biol Chem. 2003;278:18767-75 pubmed
    In humans, inactivation of the DNA polymerase eta gene (pol eta) results in sunlight sensitivity and causes the cancer-prone xeroderma pigmentosum variant syndrome (XP-V)...
  8. Tissier A, Kannouche P, Reck M, Lehmann A, Fuchs R, Cordonnier A. Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein. DNA Repair (Amst). 2004;3:1503-14 pubmed
    ..This hREV1 nuclear localization occurs independently of the presence of hpol eta. Taken together, our data suggest a central role for hREV1 as a scaffold that recruits DNA polymerases involved in TLS. ..
  9. Ohashi E, Murakumo Y, Kanjo N, Akagi J, Masutani C, Hanaoka F, et al. Interaction of hREV1 with three human Y-family DNA polymerases. Genes Cells. 2004;9:523-31 pubmed
    ..Unlike Poleta encoded by the xeroderma pigmentosum variant (XPV) gene, Polkappa is unable to bypass UV-induced DNA damage in vitro, but it is able to bypass benzo[a]pyrene (B[a]P)-..

More Information

Publications67

  1. Faili A, Aoufouchi S, Weller S, Vuillier F, Stary A, Sarasin A, et al. DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination. J Exp Med. 2004;199:265-70 pubmed
    ..pattern of patients with the cancer-prone xeroderma pigmentosum variant (XP-V) syndrome who are deficient in DNA polymerase eta (pol eta), that this enzyme could be responsible for a large part of the mutations occurring on A/T bases...
  2. Zeng X, Winter D, Kasmer C, Kraemer K, Lehmann A, Gearhart P. DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nat Immunol. 2001;2:537-41 pubmed
    To determine whether DNA polymerase eta plays a role in the hypermutation of immunoglobulin variable genes, we examined the frequency and pattern of substitutions in variable VH6 genes from the peripheral blood lymphocytes of three ..
  3. Yavuz S, Yavuz A, Kraemer K, Lipsky P. The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant. J Immunol. 2002;169:3825-30 pubmed
    ..However, its overall contribution to the somatic hypermutational process does not appear to be indispensable and in its absence other mechanisms maintain mutational activity. ..
  4. Bomgarden R, Lupardus P, Soni D, Yee M, Ford J, Cimprich K. Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling. EMBO J. 2006;25:2605-14 pubmed
    ..Taken together, these results suggest that lesion bypass and not lesion repair may raise the level of UV damage that can be tolerated before checkpoint activation, and that XPA plays a critical role in this activation. ..
  5. Zhao Y, Biertümpfel C, Gregory M, Hua Y, Hanaoka F, Yang W. Structural basis of human DNA polymerase ?-mediated chemoresistance to cisplatin. Proc Natl Acad Sci U S A. 2012;109:7269-74 pubmed publisher
    ..A hydrophobic pocket near the primer-binding site in human Pol ? is identified as a potential drug target for inhibiting translesion synthesis and, thereby, reducing chemoresistance. ..
  6. Haracska L, Johnson R, Unk I, Phillips B, Hurwitz J, Prakash L, et al. Physical and functional interactions of human DNA polymerase eta with PCNA. Mol Cell Biol. 2001;21:7199-206 pubmed
    Human DNA polymerase eta (hPoleta) functions in the error-free replication of UV-damaged DNA, and mutations in hPoleta cause cancer-prone syndrome, the variant form of xeroderma pigmentosum...
  7. Bergoglio V, Boyer A, Walsh E, Naim V, Legube G, Lee M, et al. DNA synthesis by Pol ? promotes fragile site stability by preventing under-replicated DNA in mitosis. J Cell Biol. 2013;201:395-408 pubmed publisher
    ..These data are consistent with the requirement of Pol ?-dependent DNA synthesis during S phase at replication forks stalled in CFS regions to suppress CFS instability by preventing checkpoint-blind under-replicated DNA in mitosis. ..
  8. Gohler T, Sabbioneda S, Green C, Lehmann A. ATR-mediated phosphorylation of DNA polymerase ? is needed for efficient recovery from UV damage. J Cell Biol. 2011;192:219-27 pubmed publisher
    ..Taken together, our results provide evidence for a link between DNA damage-induced checkpoint activation and translesion synthesis in mammalian cells. ..
  9. Acharya N, Yoon J, Gali H, Unk I, Haracska L, Johnson R, et al. Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis. Proc Natl Acad Sci U S A. 2008;105:17724-9 pubmed publisher
    ..We discuss the possible role of the Ub moiety on PCNA in TLS. ..
  10. Ohashi E, Hanafusa T, Kamei K, Song I, Tomida J, Hashimoto H, et al. Identification of a novel REV1-interacting motif necessary for DNA polymerase kappa function. Genes Cells. 2009;14:101-11 pubmed publisher
    ..A Polkappa mutant lacking REV1-binding activity did not complement the genotoxin-sensitivity of Polk-null mouse embryonic fibroblast cells, thereby demonstrating that the REV1-interaction is essential for Polkappa function in vivo. ..
  11. Itoh T, Linn S, Kamide R, Tokushige H, Katori N, Hosaka Y, et al. Xeroderma pigmentosum variant heterozygotes show reduced levels of recovery of replicative DNA synthesis in the presence of caffeine after ultraviolet irradiation. J Invest Dermatol. 2000;115:981-5 pubmed
    ..These results suggest that xeroderma pigmentosum variant heterozygotes can be identified by their sensitivity to ultraviolet irradiation in the presence of nontoxic levels of caffeine. ..
  12. Hidaka K, Yamada M, Kamiya H, Masutani C, Harashima H, Hanaoka F, et al. Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta. DNA Repair (Amst). 2008;7:497-506 pubmed publisher
    ..Here, we report that human DNA polymerase eta (h Poleta) incorporates oxidized dNTPs, i.e...
  13. Acharya N, Yoon J, Hurwitz J, Prakash L, Prakash S. DNA polymerase eta lacking the ubiquitin-binding domain promotes replicative lesion bypass in humans cells. Proc Natl Acad Sci U S A. 2010;107:10401-5 pubmed publisher
    ..truncated proteins promote efficient TLS opposite a cis-syn TT dimer and confer a high degree of UV resistance to XPV cells provide unambiguous evidence that the binding of PCNA via its PIP domain is essential as well as sufficient ..
  14. Biertümpfel C, Zhao Y, Kondo Y, Ramón Maiques S, GREGORY M, Lee J, et al. Structure and mechanism of human DNA polymerase eta. Nature. 2010;465:1044-8 pubmed publisher
    The variant form of the human syndrome xeroderma pigmentosum (XPV) is caused by a deficiency in DNA polymerase eta (Poleta), a DNA polymerase that enables replication through ultraviolet-induced pyrimidine dimers...
  15. Sabbioneda S, Gourdin A, Green C, Zotter A, Giglia Mari G, Houtsmuller A, et al. Effect of proliferating cell nuclear antigen ubiquitination and chromatin structure on the dynamic properties of the Y-family DNA polymerases. Mol Biol Cell. 2008;19:5193-202 pubmed publisher
    ..When DNA is exposed at replication forks, the polymerase residence times increase, and this is further facilitated by the ubiquitination of PCNA. ..
  16. Vidal A, Kannouche P, Podust V, Yang W, Lehmann A, Woodgate R. Proliferating cell nuclear antigen-dependent coordination of the biological functions of human DNA polymerase iota. J Biol Chem. 2004;279:48360-8 pubmed
    ..With the exception of DNA polymerase eta (poleta), which is defective in humans with the Xeroderma pigmentosum variant (XP-V) phenotype, little is ..
  17. Bienko M, Green C, Crosetto N, Rudolf F, Zapart G, Coull B, et al. Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science. 2005;310:1821-4 pubmed
    ..Our results indicate that Ub-binding domains of Y-family polymerases play crucial regulatory roles in TLS...
  18. Betous R, Rey L, Wang G, Pillaire M, Puget N, Selves J, et al. Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells. Mol Carcinog. 2009;48:369-78 pubmed publisher
    ..These data suggest that naturally occurring DNA structures are physiological substrates of both pol eta and pol kappa. We discuss these data in the light of their downregulation in human cancers. ..
  19. Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, et al. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature. 1999;399:700-4 pubmed
    ..Here we show that this polymerase is a human homologue of the yeast Rad30 protein, recently identified as DNA polymerase eta. This polymerase and yeast Rad30 are members of a family of damage-bypass replication proteins which ..
  20. Chen Y, Cleaver J, Hatahet Z, Honkanen R, Chang J, Yen Y, et al. Human DNA polymerase eta activity and translocation is regulated by phosphorylation. Proc Natl Acad Sci U S A. 2008;105:16578-83 pubmed publisher
    Human DNA polymerase eta (pol eta) can replicate across UV-induced pyrimidine dimers, and defects in the gene encoding pol eta result in a syndrome called xeroderma pigmentosum variant (XP-V)...
  21. Bienko M, Green C, Sabbioneda S, Crosetto N, Matic I, Hibbert R, et al. Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. Mol Cell. 2010;37:396-407 pubmed publisher
    b>DNA polymerase eta is a Y family polymerase involved in translesion synthesis (TLS)...
  22. Zlatanou A, Despras E, Braz Petta T, Boubakour Azzouz I, Pouvelle C, Stewart G, et al. The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol ? in response to oxidative DNA damage in human cells. Mol Cell. 2011;43:649-62 pubmed publisher
  23. Kusumoto R, Masutani C, Shimmyo S, Iwai S, Hanaoka F. DNA binding properties of human DNA polymerase eta: implications for fidelity and polymerase switching of translesion synthesis. Genes Cells. 2004;9:1139-50 pubmed
    ..pigmentosum variant) gene is responsible for the cancer-prone xeroderma pigmentosum syndrome and encodes DNA polymerase eta (pol eta), which catalyses efficient translesion synthesis past cis-syn cyclobutane thymine dimers (TT ..
  24. Broughton B, Cordonnier A, Kleijer W, Jaspers N, Fawcett H, Raams A, et al. Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients. Proc Natl Acad Sci U S A. 2002;99:815-20 pubmed
    ..This deficiency results from mutations in the gene encoding DNA polymerase eta, which is required for effecting translesion synthesis (TLS) past UV photoproducts...
  25. Opletalová K, Bourillon A, Yang W, Pouvelle C, Armier J, Despras E, et al. Correlation of phenotype/genotype in a cohort of 23 xeroderma pigmentosum-variant patients reveals 12 new disease-causing POLH mutations. Hum Mutat. 2014;35:117-28 pubmed
    ..XP-V is due to defects in the translesion-synthesis DNA polymerase Pol? coded by the POLH gene...
  26. Lin J, Zeman M, Chen J, Yee M, Cimprich K. SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis. Mol Cell. 2011;42:237-49 pubmed publisher
  27. Day T, Palle K, Barkley L, Kakusho N, Zou Y, Tateishi S, et al. Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication. J Cell Biol. 2010;191:953-66 pubmed publisher
    The E3 ubiquitin ligase Rad18 guides DNA Polymerase eta (Polη) to sites of replication fork stalling and mono-ubiquitinates proliferating cell nuclear antigen (PCNA) to facilitate binding of Y family trans-lesion synthesis (TLS) DNA ..
  28. Jung Y, Qian Y, Chen X. DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation. DNA Repair (Amst). 2012;11:177-84 pubmed publisher
    b>DNA polymerase eta (PolH), the product of the xeroderma pigmentosum variant (XPV) gene and a Y-family DNA polymerase, plays a pivotal role in translesion DNA synthesis...
  29. Kannouche P, Wing J, Lehmann A. Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol Cell. 2004;14:491-500 pubmed
    ..In particular, TLS by DNA polymerase eta (poleta) is the major pathway for bypassing UV photoproducts...
  30. Jung Y, Hakem A, Hakem R, Chen X. Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. Mol Cell Biol. 2011;31:3997-4006 pubmed publisher
    Polymerase eta (PolH) is necessary for translesion DNA synthesis, and PolH deficiency predisposes xeroderma pigmentosum variant (XPV) patients to cancer...
  31. Kannouche P, Fernández de Henestrosa A, Coull B, Vidal A, Gray C, Zicha D, et al. Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. EMBO J. 2002;21:6246-56 pubmed
    Y-family DNA polymerases can replicate past a variety of damaged bases in vitro but, with the exception of DNA polymerase eta (poleta), which is defective in xeroderma pigmentosum variants, there is little information on the functions of ..
  32. Sebesta M, Burkovics P, Juhasz S, Zhang S, Szabó J, Lee M, et al. Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans. DNA Repair (Amst). 2013;12:691-8 pubmed publisher
    ..In addition, the presence of PCNA on the D-loop regulates the length of the extension tracks by recruiting various polymerases and might present a regulatory point for the various recombination outcomes. ..
  33. Yuasa M, Masutani C, Eki T, Hanaoka F. Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene. Oncogene. 2000;19:4721-8 pubmed
    ..The XPV gene encodes DNA polymerase eta, which catalyzes an accurate translesion synthesis, indicating that the XPV gene contributes tumor ..
  34. Masutani C, Kusumoto R, Iwai S, Hanaoka F. Mechanisms of accurate translesion synthesis by human DNA polymerase eta. EMBO J. 2000;19:3100-9 pubmed
    The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta (pol eta), which is involved in the replication of damaged DNA...
  35. Di Lucca J, Guedj M, Lacapere J, Fargnoli M, Bourillon A, Dieude P, et al. Variants of the xeroderma pigmentosum variant gene (POLH) are associated with melanoma risk. Eur J Cancer. 2009;45:3228-36 pubmed publisher
    ..XPV results from mutations of the POLH gene that encodes a DNA translesion polymerase...
  36. Johnson R, Kondratick C, Prakash S, Prakash L. hRAD30 mutations in the variant form of xeroderma pigmentosum. Science. 1999;285:263-5 pubmed
    ..Yeast RAD30 encodes a DNA polymerase involved in the error-free bypass of ultraviolet (UV) damage...
  37. Jung Y, Liu G, Chen X. Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation. Mol Cell Biol. 2010;30:1041-8 pubmed publisher
    b>DNA polymerase eta (PolH), a Y family translesion polymerase, is required for repairing UV-induced DNA damage, and loss of PolH is responsible for early onset of malignant skin cancers in patients with xeroderma pigmentosum variant (XPV), ..
  38. Mosbech A, Gibbs Seymour I, Kagias K, Thorslund T, Beli P, Povlsen L, et al. DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. Nat Struct Mol Biol. 2012;19:1084-92 pubmed publisher
    ..Our findings establish DVC1 as a DNA damage-targeting p97 adaptor that protects cells from deleterious consequences of replication blocks and suggest an important role of p97 in ubiquitin-dependent regulation of TLS...
  39. Rey L, Sidorova J, Puget N, Boudsocq F, Biard D, Monnat R, et al. Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication. Mol Cell Biol. 2009;29:3344-54 pubmed publisher
    Human DNA polymerase eta (Pol eta) modulates susceptibility to skin cancer by promoting translesion DNA synthesis (TLS) past sunlight-induced cyclobutane pyrimidine dimers...
  40. Matsuda T, Bebenek K, Masutani C, Rogozin I, Hanaoka F, Kunkel T. Error rate and specificity of human and murine DNA polymerase eta. J Mol Biol. 2001;312:335-46 pubmed
    We describe here the error specificity of mammalian DNA polymerase eta (pol eta), an enzyme that performs translesion DNA synthesis and may participate in somatic hypermutation of immunoglobulin genes...
  41. Kannouche P, Fernández de Henestrosa A, Coull B, Vidal A, Gray C, Zicha D, et al. Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. EMBO J. 2003;22:1223-33 pubmed
    Y-family DNA polymerases can replicate past a variety of damaged bases in vitro but, with the exception of DNA polymerase eta (poleta), which is defective in xeroderma pigmentosum variants, there is little information on the functions of ..
  42. McCulloch S, Kokoska R, Masutani C, Iwai S, Hanaoka F, Kunkel T. Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity. Nature. 2004;428:97-100 pubmed
    Human DNA polymerase eta (Pol eta) modulates susceptibility to skin cancer by promoting DNA synthesis past sunlight-induced cyclobutane pyrimidine dimers that escape nucleotide excision repair (NER)...
  43. Liu G, Chen X. DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation. Mol Cell Biol. 2006;26:1398-413 pubmed
    b>DNA polymerase eta (PolH) is the product of the xeroderma pigmentosum variant (XPV) gene and a well-characterized Y-family DNA polymerase for translesion synthesis...
  44. Lee Y, Gregory M, Yang W. Human Pol ? purified with accessory subunits is active in translesion DNA synthesis and complements Pol ? in cisplatin bypass. Proc Natl Acad Sci U S A. 2014;111:2954-9 pubmed publisher
    ..We show that complete bypass of cisplatin lesions requires Pol ? to insert dCTP opposite the 3' guanine and Pol ?4 to extend the primers. ..
  45. Watanabe K, Tateishi S, Kawasuji M, Tsurimoto T, Inoue H, Yamaizumi M. Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. EMBO J. 2004;23:3886-96 pubmed
    ..In human cells, DNA polymerase eta (poleta) accumulates at stalling sites as nuclear foci, and is involved in ultraviolet (UV)-induced TLS...
  46. Yuasa M, Masutani C, Hirano A, Cohn M, Yamaizumi M, Nakatani Y, et al. A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest. Genes Cells. 2006;11:731-44 pubmed
    b>DNA polymerase eta (Poleta) is responsible for efficient translesion synthesis (TLS) past cis-syn cyclobutane thymine dimers (TT dimers), the major DNA lesions induced by UV irradiation...
  47. Bomar M, Pai M, Tzeng S, Li S, Zhou P. Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta. EMBO Rep. 2007;8:247-51 pubmed
    ..The pol eta UBZ domain represents a novel member of the C(2)H(2) zinc finger family that interacts with ubiquitin to regulate translesion synthesis. ..
  48. Choi J, Guengerich F. Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta. J Mol Biol. 2005;352:72-90 pubmed
  49. Tanioka M, Masaki T, Ono R, Nagano T, Otoshi Honda E, Matsumura Y, et al. Molecular analysis of DNA polymerase eta gene in Japanese patients diagnosed as xeroderma pigmentosum variant type. J Invest Dermatol. 2007;127:1745-51 pubmed
    b>POLH mutations were identified in 16 Japanese patients, who were diagnosed, both clinically and at a cellular level, as being of the xeroderma pigmentosum variant type (XPV)...
  50. Durando M, Tateishi S, Vaziri C. A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks. Nucleic Acids Res. 2013;41:3079-93 pubmed publisher
    ..Here, we show that Rad18 is targeted to PCNA by DNA polymerase eta (Polη), the XPV gene product that is mutated in XPV patients...
  51. Kusumoto R, Masutani C, Iwai S, Hanaoka F. Translesion synthesis by human DNA polymerase eta across thymine glycol lesions. Biochemistry. 2002;41:6090-9 pubmed
    The XP-V (xeroderma pigmentosum variant) gene product, human DNA polymerase eta (pol eta), catalyzes efficient and accurate translesion synthesis (TLS) past cis-syn thymine-thymine dimers (TT dimer)...
  52. Liu X, Zhang X, Qiao J, Fang H. Identification of a novel nonsense mutation in POLH in a Chinese pedigree with xeroderma pigmentosum, variant type. Int J Med Sci. 2013;10:766-70 pubmed publisher
    ..Furthermore, the reported molecular defects in XPV patients from previous literatures were reviewed. A homozygous c.67C>T mutation in the exon 2 of DNA polymerase eta (POLH), a novel non-sense mutation in POLH, was discovered.
  53. Lehmann A. Ubiquitin-family modifications in the replication of DNA damage. FEBS Lett. 2011;585:2772-9 pubmed publisher
    ..The Y-family polymerases themselves can be ubiquitinated and, in the case of DNA polymerase ?, this results in the polymerase being excluded from chromatin. ..
  54. Pustovalova Y, Bezsonova I, Korzhnev D. The C-terminal domain of human Rev1 contains independent binding sites for DNA polymerase ? and Rev7 subunit of polymerase ?. FEBS Lett. 2012;586:3051-6 pubmed publisher
  55. Masaki T, Ono R, Tanioka M, Funasaka Y, Nagano T, Moriwaki S, et al. Four types of possible founder mutations are responsible for 87% of Japanese patients with Xeroderma pigmentosum variant type. J Dermatol Sci. 2008;52:144-8 pubmed publisher
  56. Yoon J, Prakash L, Prakash S. Highly error-free role of DNA polymerase eta in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cells. Proc Natl Acad Sci U S A. 2009;106:18219-24 pubmed publisher
    ..These observations have important bearing on how mammalian cells have adapted to avoid the mutagenic and carcinogenic consequences of exposure to sunlight. ..
  57. Kokoska R, McCulloch S, Kunkel T. The efficiency and specificity of apurinic/apyrimidinic site bypass by human DNA polymerase eta and Sulfolobus solfataricus Dpo4. J Biol Chem. 2003;278:50537-45 pubmed
    ..of AP site bypass by two Y family TLS enzymes, Sulfolobus solfataricus DNA polymerase 4 (Dpo4) and human DNA polymerase eta (Pol eta)...
  58. Glick E, Vigna K, Loeb L. Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions. EMBO J. 2001;20:7303-12 pubmed
    Human DNA polymerase eta (hPol eta) is one of the newly identified Y-family of DNA polymerases. These polymerases synthesize past template lesions that are postulated to block replication fork progression...