POLE

Summary

Gene Symbol: POLE
Description: DNA polymerase epsilon, catalytic subunit
Alias: CRCS12, FILS, POLE1, DNA polymerase epsilon catalytic subunit A, DNA polymerase II subunit A, DNA polymerase epsilon catalytic subunit protein, polymerase (DNA directed), epsilon, catalytic subunit, polymerase (DNA) epsilon, catalytic subunit
Species: human
Products:     POLE

Top Publications

  1. Yoshida R, Miyashita K, Inoue M, Shimamoto A, Yan Z, Egashira A, et al. Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer. Eur J Hum Genet. 2011;19:320-5 pubmed publisher
    ..In particular, the F367S mutation found in the POLE gene encoding the pol epsilon catalytic subunit, which includes the proofreading domain, is the first found in ..
  2. Bermudez V, Farina A, Raghavan V, Tappin I, Hurwitz J. Studies on human DNA polymerase epsilon and GINS complex and their role in DNA replication. J Biol Chem. 2011;286:28963-77 pubmed publisher
    ..We suggest that reduction in the level of Pol ? may be less deleterious because of its collision-and-release role in lagging strand synthesis. ..
  3. Palles C, Cazier J, Howarth K, Domingo E, Jones A, Broderick P, et al. Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nat Genet. 2013;45:136-44 pubmed publisher
    ..whole-genome sequencing, supplemented by linkage and association analysis, we identified specific heterozygous POLE or POLD1 germline variants in several multiple-adenoma and/or CRC cases but in no controls...
  4. Briggs S, Tomlinson I. Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers. J Pathol. 2013;230:148-53 pubmed publisher
    ..We have recently shown that germline exonuclease domain mutations (EDMs) of POLE and POLD1 confer a high risk of multiple colorectal adenomas and carcinoma (CRC)...
  5. Valle L, Hernandez Illan E, Bellido F, Aiza G, Castillejo A, Castillejo M, et al. New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis. Hum Mol Genet. 2014;23:3506-12 pubmed publisher
    Germline mutations in DNA polymerase ? (POLE) and ? (POLD1) have been recently identified in families with multiple colorectal adenomas and colorectal cancer (CRC). All reported cases carried POLE c.1270C>G (p.Leu424Val) or POLD1 c...
  6. Meng B, Hoang L, McIntyre J, Duggan M, Nelson G, Lee C, et al. POLE exonuclease domain mutation predicts long progression-free survival in grade 3 endometrioid carcinoma of the endometrium. Gynecol Oncol. 2014;134:15-9 pubmed publisher
    b>POLE exonuclease domain mutations were recently found to occur in a subset of endometrial carcinomas and result in defective proof-reading function during DNA replication...
  7. Zahurancik W, Klein S, Suo Z. Kinetic mechanism of DNA polymerization catalyzed by human DNA polymerase ?. Biochemistry. 2013;52:7041-9 pubmed publisher
  8. Bakić M, Ratkovic M, Gledovic B, Vujovic B, Radunovic D, Babić V, et al. Cutaneous Manifestations of Tuberous Sclerosis. Acta Dermatovenerol Croat. 2018;26:73-74 pubmed
    ..of the urinary tract showed that both kidneys were enlarged with multiple cysts, with dominant cysts at the lower pole of the right kidney with a size of 55 mm and at the upper pole of the left kidney, approximately 40 mm...
  9. Hsieh C, Lin C, He J, Chiang M, Wang Y, Tsai Y, et al. Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice. Stem Cell Res Ther. 2018;9:183 pubmed publisher
    ..Mesangial cells are unique stromal cells in the renal glomerulus that form the vascular pole of the renal corpuscle along with the mesangial matrix...

More Information

Publications145 found, 100 shown here

  1. Mine I, Taguchi M, Sakurai Y, Takeuchi M. Bilateral idiopathic retinal vasculitis following coxsackievirus A4 infection: a case report. BMC Ophthalmol. 2017;17:128 pubmed publisher
    ..anterior chamber of both eyes, and multifocal retinal ischemic lesions were observed in the macula and posterior pole of both eyes. The retinal lesions corresponded with scotomas observed in Goldmann visual field test...
  2. Arora N, Saha A, Kaur M. Tuberculous pyelonephritis in children: three case reports. Paediatr Int Child Health. 2017;:1-6 pubmed publisher
    ..CECT of the abdomen showed an enlarged left kidney with focal pyelonephritis, an abscess in the upper pole and parenchymal calcification...
  3. Pichi F, Sarraf D, Morara M, Mazumdar S, Neri P, Gupta V. Pearls and pitfalls of optical coherence tomography angiography in the multimodal evaluation of uveitis. J Ophthalmic Inflamm Infect. 2017;7:20 pubmed publisher
    ..It thus provides a flow map with depth-resolved visualization of the various vascular layers in the posterior pole of the eye including the retina capillary plexus and the choroid...
  4. Chen L, Wei S, Ye Z, Xiao J, Zeng Y, Wang Y, et al. [D2 radical resection of omental bursa and No.12p and No.8p for gastric carcinoma: a retrospectively analysis from a single center in China]. Zhonghua Wei Chang Wai Ke Za Zhi. 2018;21:196-200 pubmed
    ..transverse incision was made in abdominal peritoneal layer of the esophagus, and then turned to the spleen on the pole; from the obturator to the esophagus incision was performed behind the peritoneum for the net; the uppermost edge ..
  5. Arambewela M, Liyanarachchi K, Somasundaram N, Pallewatte A, Punchihewa G. Case report: rare skeletal manifestations in a child with primary hyperparathyroidism. BMC Endocr Disord. 2017;17:45 pubmed publisher
    ..Tc 99 Sestamibi uptake scan showed abnormal tracer retention in left inferior pole of thyroid. A large parathyroid gland was removed with histology favoring parathyroid adenoma...
  6. Mahgoub S, Gabriele V, Faller E, Langer B, Wattiez A, Lecointre L, et al. Cesarean Scar Ectopic Pregnancy: Laparoscopic Resection and Total Scar Dehiscence Repair. J Minim Invasive Gynecol. 2018;25:297-298 pubmed publisher
    ..First, hysteroscopic evaluation revealed the cesarean scar dehiscence and the posterior pole of the ectopic pregnancy. Then the diagnosis of cesarean scar ectopic pregnancy was confirmed laparoscopically...
  7. Su Y, Deng M, Xiong W, Xie A, Guo J, Liang Z, et al. MicroRNA-26a/Death-Associated Protein Kinase 1 Signaling Induces Synucleinopathy and Dopaminergic Neuron Degeneration in Parkinson's Disease. Biol Psychiatry. 2019;85:769-781 pubmed publisher
    ..Rotarod, open field, and pole tests were used to evaluate the locomotor ability...
  8. Lu H, Chong J, Othman N, Vendargon S, Omar S. An uncommon and insidious presentation of renal cell carcinoma with tumor extending into the inferior vena cava and right atrium: a case report. J Med Case Rep. 2016;10:109 pubmed publisher
    ..Abdomen magnetic resonance imaging revealed a heterogenous lobulated mass in the upper and mid-pole of his right kidney with a tumor extending into his inferior vena cava and right atrium, consistent with our ..
  9. Colli Dula R, Fang X, Moraga Amador D, Albornoz Abud N, Zamora Bustillos R, Conesa A, et al. Transcriptome analysis reveals novel insights into the response of low-dose benzo(a)pyrene exposure in male tilapia. Aquat Toxicol. 2018;201:162-173 pubmed publisher
    ..involved in detoxification, IL6-associated insulin resistance, mTOR hyperactivation, mitotic cytokinesis, spindle pole and microtubule binding...
  10. Chang H, Liu K, Teng C, Lai S, Yang S, Ching H, et al. Sophora Tomentosa Extract Prevents MPTP-Induced Parkinsonism in C57BL/6 Mice Via the Inhibition of GSK-3β Phosphorylation and Oxidative Stress. Nutrients. 2019;11: pubmed publisher
    ..with four behavioral tests, including a rearing locomotor, catalepsy test, balance beam walking test, and pole test...
  11. Kalkan T, Iwasaki Y, Park C, Thomsen G. Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation. Mol Biol Cell. 2009;20:3436-50 pubmed publisher
    ..In the frog Xenopus laevis, TRAF4 mRNA is stored maternally in the egg animal pole, and in the embryo it is expressed in the gastrula marginal zone, neural plate, and cranial and trunk neural crest...
  12. Lupo B, Vialard J, Sassi F, Angibaud P, Puliafito A, Pupo E, et al. Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals. BMC Biol. 2016;14:5 pubmed publisher
    ..as modulation of Wnt signaling, telomere maintenance, vesicle trafficking, and microtubule-dependent spindle pole assembly during mitosis...
  13. Forest F, Thuret G, Gain P, Dumollard J, Peoc h M, Perrache C, et al. Optimization of immunostaining on flat-mounted human corneas. Mol Vis. 2015;21:1345-56 pubmed
    ..the localization of NCAMs exclusively in the lateral membranes of ECs, showing hexagonal organization at the apical pole and an irregular shape with increasing complexity toward the basal pole...
  14. Henkes L, Pru J, Ashley R, Anthony R, Veeramachaneni D, Gates K, et al. Embryo mortality in Isg15-/- mice is exacerbated by environmental stress. Biol Reprod. 2015;92:36 pubmed publisher
    ..By 7.5 dpc, uterine natural killer cell migration into the mesometrial pole was diminished by 65% and was less prevalent in Isg15(-/-) compared to Isg15(+/+) deciduum...
  15. Dunleavy E, Collins C. Centromere Dynamics in Male and Female Germ Cells. Prog Mol Subcell Biol. 2017;56:357-375 pubmed publisher
    ..is the altered centromere/kinetochore geometry at metaphase I, such that sister kinetochores face the same spindle pole (mono-orientation) and stay together at anaphase I...
  16. Lu Y, Lin M, Aitken R. Exposure of spermatozoa to dibutyl phthalate induces abnormal embryonic development in a marine invertebrate Galeolaria caespitosa (Polychaeta: Serpulidae). Aquat Toxicol. 2017;191:189-200 pubmed publisher
    ..disrupted in these arrested cells due to a failure to assemble the contractile actin ring, as a result of which one pole of the embryos remained as one large, undivided cell...
  17. Rodriguez Mari A, Wilson C, Titus T, Canestro C, Bremiller R, Yan Y, et al. Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish. PLoS Genet. 2011;7:e1001357 pubmed publisher
    ..meiotic cells expressed brca2; and, unexpectedly, transcripts in oocytes localized asymmetrically to the animal pole. In juvenile brca2 mutants, oocytes failed to progress through meiosis, leading to female-to-male sex reversal...
  18. Kulathilake D, Jayasundara C. A germ cell tumor in a patient with Swyer syndrome with ambiguous genitalia. BMC Res Notes. 2015;8:747 pubmed publisher
    ..tomography of abdomen showed a large complex mass lesion in relation to antero-medial aspect of the lower pole of the left kidney with para-aortic and left common iliac lymph nodes...
  19. Hori S, Tomizawa M, Maesaka F, Owari T, Morizawa Y, Nakai Y, et al. Unexpected presentation of allograft dysfunction triggered by page kidney phenomenon immediately after kidney transplantation: a case report. BMC Nephrol. 2018;19:59 pubmed publisher
    ..revealed that the blood flow of each renal artery was adequate but subcapsular hematoma was detected at the upper pole of the allograft. Capsulotomy and hematoma evacuation were performed...
  20. Kumar P, Nayyar R. Forgotten Perinephric Drain Anchored in the Tissues: Lessons to Be Learned. J Endourol Case Rep. 2017;3:123-125 pubmed publisher
    ..A small loculated subcapsular collection was also noted at the lower pole of right kidney. All efforts made to pull out the drain under local anesthesia were in vain...
  21. Yadav V, Sanyal K. Sad1 Spatiotemporally Regulates Kinetochore Clustering To Ensure High-Fidelity Chromosome Segregation in the Human Fungal Pathogen Cryptococcus neoformans. mSphere. 2018;3: pubmed publisher
    ..In ascomycetous yeast species, the role of the LINC complex in spindle pole body function and telomere clustering during meiosis has been determined...
  22. Gao Y, Tang H, Nie K, Zhu R, Gao L, Feng S, et al. Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion. Behav Brain Res. 2019;: pubmed publisher
    ..After 28 days of BCCAS, the mice were tested through pole-climbing experiments and by TUNEL, Nissl, and Bielschowsky silver staining...
  23. Scaia M, Volonteri M, Czuchlej S, Ceballos N. Estradiol and reproduction in the South American toad Rhinella arenarum (Amphibian, Anura). Gen Comp Endocrinol. 2019;273:20-31 pubmed publisher
    ..However, the Bidder's organ (BO), a structure located at one pole of each testis, is proposed to be the main source of E2 in male's toads since it expresses several ..
  24. Novotný R, Marada T, Chlupác J, Viklicky O, Fronek J. Simultaneous living donor orthotopic renal transplantation and bilateral nephrectomy for recurrent renal cell carcinoma and renal failure: case report and review of literature. Res Rep Urol. 2018;10:69-73 pubmed publisher
    ..Preoperative computed tomography of the abdomen revealed a small 8 mm tumor in the left upper kidney pole. The patient was indicated for simultaneous bilateral nephrectomy and orthotopic renal transplantation with the aim ..
  25. Macedo Júnior S, Luiz Cerutti M, Nascimento D, Farina M, Soares Santos A, de Azevedo Maia A. Methylmercury exposure for 14 days (short-term) produces behavioral and biochemical changes in mouse cerebellum, liver, and serum. J Toxicol Environ Health A. 2017;80:1145-1155 pubmed publisher
    ..motor impairment characteristic of cerebellar toxicity as noted in the following tests: rotarod, beam walking, pole, and hind limb clasping...
  26. Ward N, Green D, Higgins J, Dalmay T, Munsterberg A, Moxon S, et al. microRNAs associated with early neural crest development in Xenopus laevis. BMC Genomics. 2018;19:59 pubmed publisher
    ..Ectodermal and blastula animal pole (blastula) stage tissues were also sequenced...
  27. Wennberg A, Spira A, Pettigrew C, Soldan A, Zipunnikov V, Rebok G, et al. Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults. J Neurol Sci. 2016;365:89-95 pubmed publisher
    ..002; 95% CI -0.004, -0.0004) and temporal pole (B=-0.002; 95% CI -0.004, -0.0001), as well as reduced average thickness over AD vulnerable regions (B=-0...
  28. Xu Y, Jiang H, Hu H, Wang H, Geng T, Pan H, et al. [High-frequency ultrasonography for diagnosis and differential diagnosis of acute scrotum in children]. Zhonghua Nan Ke Xue. 2016;22:996-1000 pubmed
    ..in 116 cases, in which ultrasonography manifested nodules with round or oval abnormal echoes between the upper pole of the testis and caput epididymidis, first hypoechoic and then gradually increased, heterogeneous internally...
  29. Kleinhans N, Yang C, Strachan E, Buchwald D, Maravilla K. Alterations in Connectivity on Functional Magnetic Resonance Imaging with Provocation of Lower Urinary Tract Symptoms: A MAPP Research Network Feasibility Study of Urological Chronic Pelvic Pain Syndromes. J Urol. 2016;195:639-45 pubmed publisher
    ..the right premotor cortex/supplementary motor area and the insular cortex, and between the amygdala and the frontal pole/medial orbital frontal cortex, the hypothalamus, the insular cortex, the thalamus and the anterior cingulate cortex...
  30. Preston S, Jiao Y, Jabbar A, McGee S, Laleu B, Willis P, et al. Screening of the 'Pathogen Box' identifies an approved pesticide with major anthelmintic activity against the barber's pole worm. Int J Parasitol Drugs Drug Resist. 2016;6:329-334 pubmed publisher
    ..we tested these compounds for activity against parasitic stages of the nematode Haemonchus contortus (barber's pole worm)...
  31. Kadar A, Morsy M, Sur Y, Laungani A, Akdağ O, Moran S. The Vascular Anatomy of the Capitate: New Discoveries Using Micro-Computed Tomography Imaging. J Hand Surg Am. 2017;42:78-86 pubmed publisher
    ..Most vessels enter the capitate at the distal half and supply the proximal pole in a retrograde fashion...
  32. Yucel M, Ozcan S, Tirpan G, Bağcioğlu M, Aydın A, Demirbas A, et al. The Respiratory Induced Kidney Motion: Does It Really Effect the Shock Wave Lithotripsy?. Urol J. 2017;15:11-15 pubmed publisher
    ..Stones greater than 20 mm, and lower pole stones were also excluded. The movement of the kidneys were measured with fluoroscopy guidance...
  33. Liang Y, Naber S, Chatterjee A. Anatomic and terminological description and processing of breast pathologic specimens from oncoplastic large volume displacement surgeries. Mod Pathol. 2018;31:1004-1011 pubmed publisher
    ..of one or several components, which include lateral wall, superior keyhole, medial wall, lateral wing, inferior pole, and medial wing. We also present specimen documentation and sectioning procedures used in our institution...
  34. Chastain J, Sanders M, Curtis M, Chemuturi N, Gadd M, Kapin M, et al. Distribution of topical ocular nepafenac and its active metabolite amfenac to the posterior segment of the eye. Exp Eye Res. 2016;145:58-67 pubmed publisher
    ..Nepafenac peak levels in sub-samples posterior to the eye equator and inclusive of the posterior pole (E-PP) were 55.1, 4.03 and 2.72 nM, respectively, at 0.25 or 0...
  35. Kumar R, Shamet G, Mehta H, Alam N, Kaushal R, Chaturvedi O, et al. Regeneration complexities of Pinus gerardiana in dry temperate forests of Indian Himalaya. Environ Sci Pollut Res Int. 2016;23:7732-43 pubmed publisher
    ..The distribution of seedling, sapling, pole and trees was not uniform at different sites and less number of plots in each site were observed to have effective ..
  36. Fujii M, Sakaguchi A, Kamata R, Nagao M, Kikuchi Y, Evans S, et al. Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle. Nat Commun. 2017;8:14664 pubmed publisher
    ..at the lateral sides of the cardiac crescent, excluding early differentiating regions, and continues in the venous pole, which gives rise to the SV. Lineage-tracing analysis revealed that descendants of Sfrp5-expressing cells at E7...
  37. Wang K, Cai H, Kong D, Cui Q, Zhang D, Wu G. The Identification, Preservation and Classification of the External Branch of the Superior Laryngeal Nerve in Thyroidectomy. World J Surg. 2017;41:2521-2529 pubmed publisher
    ..of the superior laryngeal nerve was determined by the distance between the upper edge of the superior thyroid pole and the lowest point of the nerve when the thyroid lobe was retracted in the lateral and inferior direction...
  38. Cline J. Is electroweak baryogenesis dead?. Philos Trans A Math Phys Eng Sci. 2018;376: pubmed publisher
    ..Fine tuning of parameters is required, or large couplings leading to a Landau pole at scales just above the new physics introduced...
  39. Pillai A, Howell K, Ahmed A, Weinberg D, Allen K, Bruggemann J, et al. Association of serum VEGF levels with prefrontal cortex volume in schizophrenia. Mol Psychiatry. 2016;21:686-92 pubmed publisher
    ..9, P=0.005). A significant inverse correlation (r=-0.40, P=0.002) between serum VEGF and total frontal pole volume was found in patients with schizophrenia/schizoaffective disorder...
  40. Broyer R, Monfort E, Wilhelm J. Cup regulates oskar mRNA stability during oogenesis. Dev Biol. 2017;421:77-85 pubmed publisher
    ..that loss of cup disrupts the localization of both the oskar mRNA and its associated proteins to the posterior pole of the developing oocyte...
  41. Sánchez Lamar A, Piloto Ferrer J, Fiore M, Stano P, Cozzi R, Tofani D, et al. Xanthium strumarium extract inhibits mammalian cell proliferation through mitotic spindle disruption mediated by xanthatin. J Ethnopharmacol. 2016;194:781-788 pubmed publisher
    ..strumarium whole extract inhibits assembly of the mitotic spindle and spindle-pole separation, thereby heavily affecting mitosis, impairing the metaphase to anaphase transition and inducing ..
  42. Wei Y, Collin G, Mandl R, Cahn W, Keunen K, Schmidt R, et al. Cortical magnetization transfer abnormalities and connectome dysconnectivity in schizophrenia. Schizophr Res. 2018;192:172-178 pubmed publisher
    ..schizophrenia patients, including bilateral rostral middle frontal areas, right pars orbitalis, and right frontal pole. Furthermore, cortical MTR alterations between patients and controls were significantly correlated with the level ..
  43. Jade S, Shrungeshwara T, Kumar K, Choudhury P, Dumka R, Bhu H. India plate angular velocity and contemporary deformation rates from continuous GPS measurements from 1996 to 2015. Sci Rep. 2017;7:11439 pubmed publisher
    ..Our newly estimated India-ITRF2008 Euler pole is located significantly closer to the plate with ~3% higher angular velocity than all previous estimates and thus ..
  44. Lasave A. Current interpretation of optical coherence tomography in the posterior pole. Arch Soc Esp Oftalmol. 2016;91:3-9 pubmed publisher
    ..The current nomenclature of normal macular architecture represented in vivo on spectral domain OCT technology provides a clear and valid anatomical interpretation that can be applied, not only in research, but also in everyday practice. ..
  45. Hayashi J, Luo C, Mayfield J, Hsu T, Fukuda T, Walfield A, et al. Spatially distinct and metabolically active membrane domain in mycobacteria. Proc Natl Acad Sci U S A. 2016;113:5400-5 pubmed publisher
    ..Seamless coordination of cell growth with cell envelope elongation at the pole maintains this barrier...
  46. Caso F, Agosta F, Volonté M, Ferraro P, Tiraboschi P, Copetti M, et al. Cognitive impairment in progressive supranuclear palsy-Richardson's syndrome is related to white matter damage. Parkinsonism Relat Disord. 2016;31:65-71 pubmed publisher
    ..patients had a focal, bilateral cortical thinning mainly located in the prefrontal/precentral cortex and temporal pole. PSPs patients also showed a distributed white matter damage involving the main tracts including the superior ..
  47. Kupke T, Malsam J, Schiebel E. A ternary membrane protein complex anchors the spindle pole body in the nuclear envelope in budding yeast. J Biol Chem. 2017;292:8447-8458 pubmed publisher
    In budding yeast (Saccharomyces cerevisiae) the multilayered spindle pole body (SPB) is embedded in the nuclear envelope (NE) at fusion sites of the inner and outer nuclear membrane...
  48. Fatoba O, Kloster E, Reick C, Saft C, Gold R, Epplen J, et al. Activation of NPY-Y2 receptors ameliorates disease pathology in the R6/2 mouse and PC12 cell models of Huntington's disease. Exp Neurol. 2018;302:112-128 pubmed publisher
    ..or NPY13-36 led to an improved motor function in R6/2 mice as revealed by rotarod performance, vertical pole test, and hindlimb clasping behaviour...
  49. Bhangoo M, Boasberg P, Mehta P, Elvin J, Ali S, Wu W, et al. Tumor Mutational Burden Guides Therapy in a Treatment Refractory POLE-Mutant Uterine Carcinosarcoma. Oncologist. 2018;23:518-523 pubmed publisher
    ..Initial molecular testing did not assess tumor mutational burden, DNA polymerase ? (POLE), or microsatellite status...
  50. Ogi T, Limsirichaikul S, Overmeer R, Volker M, Takenaka K, Cloney R, et al. Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Mol Cell. 2010;37:714-27 pubmed publisher
    ..The remaining repair synthesis is dependent on pol epsilon, recruitment of which is dependent on the alternative clamp loader CTF18-RFC. ..
  51. Tisler M, Wetzel F, Mantino S, Kremnyov S, Thumberger T, Schweickert A, et al. Cilia are required for asymmetric nodal induction in the sea urchin embryo. BMC Dev Biol. 2016;16:28 pubmed publisher
    ..Expression of foxj1 and dnah9 suggested that archenteron cilia were motile. Cilia were polarized to the posterior pole of cells, a prerequisite of directed flow...
  52. Tu Y, Takamizawa H, Han B, Shimizu Y, Inoue K, Toyama T, et al. Influence of laser power on atom probe tomographic analysis of boron distribution in silicon. Ultramicroscopy. 2017;173:58-63 pubmed publisher
    ..are almost uniform and homogeneous when using low laser power, while clear B accumulation at the low-index pole of single-crystalline Si and segregation along the grain boundaries in polycrystalline Si are observed when using ..
  53. Ehrle H, Guidry J, Iacovetto R, Salisbury A, Sandidge D, Bowman G. Polar Organizing Protein PopZ Is Required for Chromosome Segregation in Agrobacterium tumefaciens. J Bacteriol. 2017;199: pubmed publisher
    ..In this species, we find that PopZ molecules are relocated from the old pole to the new pole in the minutes following cell division...
  54. Nagai Y, Aram J, Koepp M, Lemieux L, Mula M, Critchley H, et al. Epileptic Seizures are Reduced by Autonomic Biofeedback Therapy Through Enhancement of Fronto-limbic Connectivity: A Controlled Trial and Neuroimaging Study. EBioMedicine. 2018;27:112-122 pubmed publisher
    ..with enhanced functional connectivity between right amygdala and both the orbitofrontal cortex (OFC) and frontal pole (FP)...
  55. So Y, Kim M, Kim S, Son Y. Lateral lymph node metastasis in papillary thyroid carcinoma: A systematic review and meta-analysis for prevalence, risk factors, and location. Int J Surg. 2018;50:94-103 pubmed publisher
    ..67-2.89, p < .0001), male sex (pooled OR = 1.72, 95% CI = 1.50-1.98, p < .0001), upper pole location (pooled OR = 2.96, 95% CI = 1.93-4.53, p < .0001), tumor size ≥1...
  56. Kahathuduwa C, Davis T, O Boyle M, Binks M. Do scores on the Food Craving Inventory and Three-Factor Eating Questionnaire correlate with expected brain regions of interest in people with obesity?. Physiol Behav. 2018;188:1-10 pubmed publisher
    ..e. bilateral lateral frontal pole, dorsolateral prefrontal cortex and dorsal anterior cingulate cortex). Post- vs...
  57. Ortega Anaya J, Hernández Santoyo A. Functional characterization of a fatty acid double-bond hydratase from Lactobacillus plantarum and its interaction with biosynthetic membranes. Biochim Biophys Acta. 2015;1848:3166-74 pubmed publisher
    ..Interestingly, it was found that the linoleic acid molecule arranges around a methionine residue in both sites (Met154 and Met81, respectively) that acts as a rigid pole, thus playing a key role in binding unsaturated fatty acids.
  58. Wamelink K, Marcoux J, Walrath S. Rare Proximal Diaphyseal Stress Fractures of the Fifth Metatarsal Associated With Metatarsus Adductus. J Foot Ankle Surg. 2016;55:788-93 pubmed publisher
    ..of English surgeon Robert Jones, who sustained a fracture to his fifth metatarsal while dancing around a tent pole, metatarsal fractures were thought to be the result of direct trauma to the foot...
  59. Kahloun R, Ben Amor H, Ksiaa I, Zina S, Jelliti B, Ben Yahia S, et al. Multimodal imaging in a case of bilateral outer retinitis associated with mumps infection. Int Ophthalmol. 2018;38:339-343 pubmed publisher
    ..Ophthalmoscopy showed confluent areas of outer retinitis involving the posterior pole and the periphery with a centrifugal gyrate pattern...
  60. Buffa R, Mereu E, Succa V, Latini V, Marini E. Specific BIVA recognizes variation of body mass and body composition: Two related but different facets of nutritional status. Nutrition. 2017;35:1-5 pubmed publisher
    ..region of higher fat-free mass), whereas those above the third FM% quartiles were on the right and toward the upper pole (the region of higher FM%)...
  61. Gonzalez Martinez A, Muñoz Palazon B, Maza Márquez P, Rodriguez Sanchez A, Gonzalez Lopez J, Vahala R. Performance and microbial community structure of a polar Arctic Circle aerobic granular sludge system operating at low temperature. Bioresour Technol. 2018;256:22-29 pubmed publisher
    ..Our study suggests that AGS technologies inoculated with North Pole sludge could be operated, in cold regions for a period longer than 3?months (winter season) under 5?°C of water ..
  62. Preston S, Jabbar A, Gasser R. A perspective on genomic-guided anthelmintic discovery and repurposing using Haemonchus contortus. Infect Genet Evol. 2016;40:368-373 pubmed publisher
    ..transcriptomes of socioeconomically important parasitic nematodes of animals; provide an account of the barber's pole worm (Haemonchus contortus) and emerging drug resistance problems in this and related worms; we also propose a ..
  63. Ciejka E, Skibska B, GorÄ…ca A. [Influence of low frequency magnetic field used in magnetotherapy on interleukin 6 (IL-6) contents in rat heart and brain]. Med Pr. 2017;68:517-523 pubmed publisher
    ..U zwierząt oznaczono stężenia IL-6 po zakończeniu ekspozycji na pole magnetyczne...
  64. Ono M, Preece D, Duquette M, Forer A, Berns M. Mitotic tethers connect sister chromosomes and transmit "cross-polar" force during anaphase A of mitosis in PtK2 cells. Biomed Opt Express. 2017;8:4310-4315 pubmed publisher
    ..the tether between chromosomes, create chromosome fragments attached to the tether which move toward the opposite pole, and to trap the tethered fragments...
  65. Enzinger S, Burger H, Gaggl A. Reconstruction of the mandibular condyle using the microvascular lateral femoral condyle flap. Int J Oral Maxillofac Surg. 2018;47:603-607 pubmed publisher
    ..An osteochondral flap according to the condyle defect is harvested from the anterior pole of the knee. The flap is banded according to the defect and fixed to the mandibular neck with three miniscrews...
  66. Fischer L, Nguyen D. Double-Chamber Tissue Expanders Optimize Lower Pole Expansion in Immediate Breast Reconstruction Requiring Adjuvant Radiation Therapy. Ann Plast Surg. 2016;76 Suppl 3:S171-4 pubmed publisher
    ..These complications may be attributed to inadequate lower pole expansion causing increased pressure on the suture line...
  67. Liu Z, Wang Q, You Y, Yin P, Ding H, Bao X, et al. The role of the temporal pole in modulating primitive auditory memory. Neurosci Lett. 2016;619:196-202 pubmed publisher
    ..Previous anatomical, brain-imaging, and neurophysiological studies have suggested that the temporal pole (TP), part of the parahippocampal region in the transitional area between perirhinal cortex and superior/inferior ..
  68. Das A, Valdez T, Vargas J, Saksupapchon P, Rachapudi P, Ge Z, et al. Volume estimation of tonsil phantoms using an oral camera with 3D imaging. Biomed Opt Express. 2016;7:1445-57 pubmed publisher
    ..For better assessment of the inferior pole of the tonsils and tongue base flexible laryngoscopes are required which only provide a two dimensional (2D) ..
  69. Servetnick M, Steinworth B, Babonis L, Simmons D, Salinas Saavedra M, Martindale M. Cas9-mediated excision of Nematostella brachyury disrupts endoderm development, pharynx formation and oral-aboral patterning. Development. 2017;144:2951-2960 pubmed publisher
    ..and outside the Nvbrachyury expression domain is affected, including downregulation of Wnt genes at the oral pole. Our results point to an ancient role for brachyury in morphogenesis, cell polarity and the patterning of ..
  70. Zheng C, Wu Q, Jin Y, Wu Y. Regional gray matter volume is associated with trait modesty: Evidence from voxel-based morphometry. Sci Rep. 2017;7:14920 pubmed publisher
    ..the dorsomedial prefrontal cortex, right dorsolateral prefrontal cortex, left superior temporal gyrus/left temporal pole, and right posterior insular cortex...
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    ..Using the proposed control procedure, the state variables of cart-pole system are converged to decoupled terminal sliding surfaces and their equilibrium points in the finite time...
  72. Lee B, Kiburz B, Amon A. Spo13 maintains centromeric cohesion and kinetochore coorientation during meiosis I. Curr Biol. 2004;14:2168-82 pubmed
    ..I, physical linkages called chiasmata need to form between homologs, sister chromatid cohesion has to be lost in a stepwise manner, and sister kinetochores must attach to microtubules emanating from the same spindle pole (coorientation).
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    ..first line option for patients with small, endophytic diverticula, particularly those located in the upper and mid pole. The laparoscopic approach is more invasive but should be considered for large diverticula that are exophytic with ..
  74. Schilling T, Borst A. Local motion detectors are required for the computation of expansion flow-fields. Biol Open. 2015;4:1105-8 pubmed publisher
    ..Tethered flying fruit flies, when confronted with an expansion flow-field, reliably turn away from the pole of expansion when presented laterally, or perform a landing response when presented frontally...
  75. Wei Y, Tse P, Du B, Wang Y. An innovative fixed-pole numerical approximation for fractional order systems. ISA Trans. 2016;62:94-102 pubmed publisher
    ..A careful simulation study is reported to illustrate the effectiveness of the proposed scheme. To exhibit the superiority clearly, the results are compared with that of the published fixed-pole finite model method.
  76. Miyamoto T, Ando H, Asaka R, Yamada Y, Shiozawa T. Mutation analysis by whole exome sequencing of endometrial hyperplasia and carcinoma in one patient: Abnormalities of polymerase epsilon and the phosphatidylinositol-3 kinase pathway. J Obstet Gynaecol Res. 2017;: pubmed publisher
    ..These common mutations included polymerase epsilon (POLE) and DNA mismatch repair (MMR) genes, indicating that an ultra-mutated phenotype, and also included PTEN and PIK3CA...
  77. Guss M, Mitgang J, Sapienza A. Scaphoid Healing Required for Unrestricted Activity: A Biomechanical Cadaver Model. J Hand Surg Am. 2018;43:134-138 pubmed publisher
    ..Biomechanical testing was performed using an Instron testing machine, with a load applied to the scaphoid's distal pole. Load to failure and stiffness were measured. Intact scaphoids had an average load to failure of 610.0 N...
  78. Haraldsdottir S, Hampel H, Tomsic J, Frankel W, Pearlman R, de la Chapelle A, et al. Colon and endometrial cancers with mismatch repair deficiency can arise from somatic, rather than germline, mutations. Gastroenterology. 2014;147:1308-1316.e1 pubmed publisher
    ..Tumor DNA was sequenced for MLH1, MSH2, MSH6, PMS2, EPCAM, POLE, and POLD1 with ColoSeq and mutation frequencies were established...
  79. Han J, Lee Y, Kim M, Lee M, Im Y, Kim S, et al. Conservative Management of Segmental Multicystic Dysplastic Kidney in Children. Urology. 2015;86:1013-8 pubmed publisher
    ..Segmental MCDK was classified as typical when it was localized to the upper pole of a duplex collecting system, and otherwise as atypical...
  80. Sugiyama Y, Shelley E, Yoder B, Kozmik Z, May Simera H, Beales P, et al. Non-essential role for cilia in coordinating precise alignment of lens fibres. Mech Dev. 2016;139:10-7 pubmed publisher
    ..fibre cell has an apically situated primary cilium that is polarised to the side of the cell facing the anterior pole of the lens...
  81. Yoo J, Kim D, Choi J, Jeong B. Treatment effect of methylphenidate on intrinsic functional brain network in medication-naïve ADHD children: A multivariate analysis. Brain Imaging Behav. 2018;12:518-531 pubmed publisher
    ..clustering coefficient (CC) of the global network and nodes, the left fronto-parietal, cerebellum, and occipital pole-visual network, were decreased...
  82. Castellucci E, He T, Goldstein D, Halmos B, Chuy J. DNA Polymerase É› Deficiency Leading to an Ultramutator Phenotype: A Novel Clinically Relevant Entity. Oncologist. 2017;22:497-502 pubmed publisher
    ..Instead, mutations in POLE lead to impaired proofreading intrinsic to Pol É› during DNA replication resulting in a dramatically ..
  83. Ginda K, Santi I, Bousbaine D, Zakrzewska Czerwinska J, Jakimowicz D, McKinney J. The studies of ParA and ParB dynamics reveal asymmetry of chromosome segregation in mycobacteria. Mol Microbiol. 2017;105:453-468 pubmed publisher
    ..The rapid movement of segrosomes is dependent on ParA that is transiently associated with the new pole. Remarkably in M. tuberculosis, the movement of the ParB complex is much slower than in M...
  84. Park W, Jeong J. Total Power Radiometer for Medical Sensor Applications Using Matched and Mismatched Noise Sources. Sensors (Basel). 2017;17: pubmed publisher
    ..A single-pole-triple-throw (SP3T) switch is placed between the antenna and the receiver, while a personal computer is used to ..
  85. Landa G, Pham K. Manual Removal of Primary Posterior Capsular Plaques Using Retinal End-Grasping Forceps. Ophthalmol Ther. 2017;6:351-353 pubmed publisher
    ..using a technique inspired by the experience of retina surgeon in the peeling of membranes from the posterior pole. Retinal end-grasping forceps were used to peel the plaque from the posterior capsule...
  86. Pitaval A, Senger F, Letort G, Gidrol X, Guyon L, Sillibourne J, et al. Microtubule stabilization drives 3D centrosome migration to initiate primary ciliogenesis. J Cell Biol. 2017;216:3713-3728 pubmed publisher
    ..Together, our data elucidate the hitherto unexplored mechanism of centrosome migration and show that it is driven by the increase and clustering of mechanical forces to push the centrosome toward the cell apical pole.
  87. Cho J, Kim J, Cho W, Gujjar P, Oh C, Oh J. Comminuted inferior pole fracture of patella can be successfully treated with rim-plate-augmented separate vertical wiring. Arch Orthop Trauma Surg. 2018;138:195-202 pubmed publisher
    We present the surgical technique of rim-plate-augmented separate vertical wiring for comminuted inferior pole fracture of the patella and report the clinical outcomes...
  88. Shi F, Pei A, Vailionis A, Xie J, Liu B, Zhao J, et al. Strong texturing of lithium metal in batteries. Proc Natl Acad Sci U S A. 2017;114:12138-12143 pubmed publisher
    ..X-ray diffraction pole-figure analysis demonstrates that the texture of Li deposits is primarily dependent on the type of additive or ..
  89. Grangeon R, Zupan J, Jeon Y, Zambryski P. Loss of PopZ At activity in Agrobacterium tumefaciens by Deletion or Depletion Leads to Multiple Growth Poles, Minicells, and Growth Defects. MBio. 2017;8: pubmed publisher
    i>Agrobacterium tumefaciens grows by addition of peptidoglycan (PG) at one pole of the bacterium...
  90. Kang Y, Galal W, Farina A, Tappin I, Hurwitz J. Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis. Proc Natl Acad Sci U S A. 2012;109:6042-7 pubmed publisher
    ..These findings suggest that the coordinated action of these replication complexes supports leading strand synthesis. ..
  91. Range R, Wei Z. An anterior signaling center patterns and sizes the anterior neuroectoderm of the sea urchin embryo. Development. 2016;143:1523-33 pubmed publisher
    ..to potentiate the Wnt/JNK signaling pathway governing the positioning of the ANE territory around the anterior pole, whereas high expression levels of sFRP1/5 antagonize Wnt/JNK signaling...
  92. Medlock G, Wohlgemut J, Stevenson I, Johnstone A. Magnetic resonance imaging investigation of radio-lunate relations: use in assessing distal radial fracture reduction. J Hand Surg Eur Vol. 2017;42:271-274 pubmed publisher
    ..Measurements were made from the superior pole of the lunate to this line. This distance did not change significantly with rotation...