POLA1

Summary

Gene Symbol: POLA1
Description: DNA polymerase alpha 1, catalytic subunit
Alias: NSX, POLA, p180, DNA polymerase alpha catalytic subunit, DNA polymerase alpha catalytic subunit p180, polymerase (DNA directed), alpha 1, catalytic subunit, polymerase (DNA) alpha 1, catalytic subunit, polymerase (DNA-directed), alpha (70kD)
Species: human
Products:     POLA1

Top Publications

  1. Matsuo K, Shintani S, Tsuji T, Nagata E, Lerman M, McBride J, et al. p12(DOC-1), a growth suppressor, associates with DNA polymerase alpha/primase. FASEB J. 2000;14:1318-24 pubmed
    ..These data support a role of p12(DOC-1) as a regulator of DNA replication by direct inhibition of pol-alpha:primase or by negatively regulating the CDK2-mediated phosphorylation of pol-alpha:primase. ..
  2. Smith R, Nasheuer H. Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180. FEBS Lett. 2002;527:143-6 pubmed
    ..We show that the C-terminal 67 amino acid residues of the human p180 subunit are essential for SV40 DNA replication as they are required for binding of the p68 subunit and play a role ..
  3. Zhu W, Ukomadu C, Jha S, Senga T, Dhar S, Wohlschlegel J, et al. Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. Genes Dev. 2007;21:2288-99 pubmed
    ..And-1/Ctf4 (Chromosome transmission fidelity 4) interacts with Mcm10, which associates with MCM2-7, and with the p180 subunit of DNA pol alpha. And-1 is essential for DNA synthesis and the stability of p180 in mammalian cells...
  4. Gayet Ageron A, Laurent F, Schrenzel J, Charton B, Jimenez Getaz G, Tangomo M, et al. Performance of the 47-kilodalton membrane protein versus DNA polymerase I genes for detection of Treponema pallidum by PCR in ulcers. J Clin Microbiol. 2015;53:976-80 pubmed publisher
    ..In this study, we sequentially tested 272 specimens from patients with sexually transmitted ulcers using Tp-PCR targeting the tpp47 and then polA genes. The two methods showed similar accuracies and an almost-perfect agreement.
  5. Villa C, Miquel C, Mosses D, Bernier M, Di Stefano A. The 2016 World Health Organization classification of tumours of the central nervous system. Presse Med. 2018;47:e187-e200 pubmed publisher
    ..Importantly, the French POLA cohort allowed to test the clinical impact of the new criteria introduced by 2016 WHO classification of CNS tumours ..
  6. Ogawa Y, Imai Y, Yoshihara S, Fujikura H, Hirai N, Sato M, et al. Pulmonary involvement of secondary syphilis. Int J STD AIDS. 2018;29:89-91 pubmed publisher
    ..positive, and the specimen of one of the pulmonary nodules obtained by transthoracic biopsy was positive for the polA gene of Treponema pallidum...
  7. Farías G, Fréal A, Tortosa E, Stucchi R, Pan X, Portegies S, et al. Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity. Neuron. 2019;102:184-201.e8 pubmed publisher
    ..The ER-shaping protein P180, present in axonal ER tubules, controls axon specification by regulating local MT remodeling...
  8. Zukunft S, Prehn C, Röhring C, Moller G, Hrabe de Angelis M, Adamski J, et al. High-throughput extraction and quantification method for targeted metabolomics in murine tissues. Metabolomics. 2018;14:18 pubmed publisher
    ..protocol optimized for tissue metabolite quantification by the targeted metabolomics AbsoluteIDQp180 Kit (Biocrates)...
  9. Mihály D, Papp G, Mervai Z, Reszegi A, Tátrai P, Szalóki G, et al. The oncomir face of microRNA-206: A permanent miR-206 transfection study. Exp Biol Med (Maywood). 2018;243:1014-1023 pubmed publisher
    ..mRNA expression of the target genes of miR-206 (SMARCB1, ACTL6A, CCND1, POLA1, NOTCH3, MET, and G6PD) and SMARCB1 protein expression were examined with quantitative real-time polymerase chain ..

More Information

Publications168 found, 100 shown here

  1. Czysz A, South C, Gadad B, Arning E, Soyombo A, Bottiglieri T, et al. Can targeted metabolomics predict depression recovery? Results from the CO-MED trial. Transl Psychiatry. 2019;9:11 pubmed publisher
    ..The AbsoluteIDQ™ p180 kit was used to investigate whether plasma metabolites (sphingomyelins, lysophosphatidylcholines, ..
  2. Nozaki S, Niki H. Exonuclease III (XthA) Enforces In Vivo DNA Cloning of Escherichia coli To Create Cohesive Ends. J Bacteriol. 2019;201: pubmed publisher
    ..We also show that iVEC activity is reduced by deletion of the C-terminal domain of DNA polymerase I (PolA). Collectively, these results suggest the following mechanism of iVEC...
  3. Villar Torres M, Repullés Albelda A, Montero F, Raga J, Blasco Costa I. Neither Diplectanum nor specific: a dramatic twist to the taxonomic framework of Diplectanum (Monogenea: Diplectanidae). Int J Parasitol. 2019;49:365-374 pubmed publisher
    ..Sciaena umbra, Umbrina canariensis and Umbrina cirrosa) and locality (Burriana, Sant Carles de la Ràpita and Santa Pola (Spain)) together with five individuals of the type species Diplectanum aequans...
  4. Ciejka E, Skibska B, GorÄ…ca A. [Influence of low frequency magnetic field used in magnetotherapy on interleukin 6 (IL-6) contents in rat heart and brain]. Med Pr. 2017;68:517-523 pubmed publisher
    ..Dlatego ważne jest dokładne poznanie i usystematyzowanie wiedzy w zakresie mechanizmów oddziaływania pola magnetycznego na organizmy żywe, dotyczy to zdrowia osób eksponowanych, narażonych na ich działanie...
  5. Quesada J, Nolasco A, Moncho J. [Comparison of Google and Yahoo applications for geocoding of postal addresses in epidemiological studies]. Rev Esp Salud Publica. 2013;87:201-6 pubmed publisher
    ..30 addresses were geocoded with those two sources and the GPS in Santa Pola (Alicante) and Alicante city...
  6. Veiga S, Wahrheit J, Rodríguez Martín A, Sonntag D. Quantitative Metabolomics in Alzheimer's Disease: Technical Considerations for Improved Reproducibility. Methods Mol Biol. 2018;1779:463-470 pubmed publisher
    ..The AbsoluteIDQ® p180 Kit (Biocrates, Life Science AG, Innsbruck, Austria) is to date the only commercially available, validated, and ..
  7. Wang S, Wang J, Zhang R, Zhao A, Zheng X, Yan D, et al. Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach. Cardiovasc Diabetol. 2019;18:8 pubmed publisher
    ..Targeted metabolic profiles of serum metabolites were determined using an AbsoluteIDQ™ p180 Kit (BIOCRATES Life Sciences AG, Innsbruck, Austria)...
  8. Starokadomskyy P, Gemelli T, Rios J, Xing C, Wang R, Li H, et al. DNA polymerase-? regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. Nat Immunol. 2016;17:495-504 pubmed publisher
    ..We discovered that XLPDR is caused by an intronic mutation that disrupts the expression of POLA1, which encodes the catalytic subunit of DNA polymerase-?...
  9. Lo P, Huang Y, Corcoran D, Jiao R, Deng W. Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation. J Cell Sci. 2019;132: pubmed publisher
    ..Here, we report another side of CAF1, wherein the subunits CAF1-p105 and CAF1-p180 (also known as CAF1-105 and CAF1-180, respectively) inhibit expression of Notch target genes and show this is ..
  10. Feoktistova E, Skamrov A, Goryunova L, Khaspekov G, Osyaeva M, Rodnenkov O, et al. [Analysis of gene expression pattern in peripheral blood leukocytes during experimental heat wave]. Biomed Khim. 2017;63:139-146 pubmed publisher
    ..v Moskve. V ispytanii uchastvovali 6 prakticheski zdorovykh dobrovol'tsev muzhskogo pola. Analiz ékspressii genov provodili s ispol'zovaniem obraztsov total'no? RNK, vydelenno? iz krovi uchastnikov é..
  11. Llena C, Martínez Galdón O, Forner L, Gimeno Mallench L, Rodríguez Lozano F, Gambini J. Hydrogen Peroxide Diffusion through Enamel and Dentin. Materials (Basel). 2018;11: pubmed publisher
    ..Human enamel-dentin discs were obtained and divided into 20 groups. Four commercial products based on HP (Pola Office+(PO), Perfect Bleach (PB), Norblanc Office-automix (NO), and Boost (BT)), and one based on CP (PolaDay CP (..
  12. Lau C, Siskos A, Maitre L, Robinson O, Athersuch T, Want E, et al. Determinants of the urinary and serum metabolome in children from six European populations. BMC Med. 2018;16:202 pubmed publisher
    ..nuclear magnetic resonance (NMR) spectroscopy and a targeted LC-MS/MS metabolomic assay (Biocrates AbsoluteIDQ p180 kit). We identified both urinary and serum creatinine to be positively associated with age...
  13. Pinto A, Bridi E, Amaral F, França F, Turssi C, Pérez C, et al. Enamel Mineral Content Changes After Bleaching With High and Low Hydrogen Peroxide Concentrations: Colorimetric Spectrophotometry and Total Reflection X-ray Fluorescence Analyses. Oper Dent. 2017;42:308-318 pubmed publisher
    ..in-office use) evaluated were Whiteness HP Maxx/FGM (35% HP), Whiteness HP Blue/FGM (35% HP, 2% calcium gluconate), Pola Office+/SDI (37.5% HP, 5% potassium nitrate), and Opalescence Boost/Ultradent (38% HP, 1...
  14. Gumanova N, Klimushina M, Gavrilova N, Metelskaya V. [Combined markers of initial stages of coronary atherosclerosis]. Biomed Khim. 2017;63:272-277 pubmed publisher
    ..sposoben sluzhit' novym diagnosticheskim testom khoroshego kachestva dlia stratifikatsii patsientov muzhskogo pola bez porazheni? KA, no s klinichesko? kartino?, kharakterno? dlia KBS, i nachal'no? stepen'iu ateroskleroza KA ot ..
  15. Cui X, Zhang H, Palazzo A. p180 promotes the ribosome-independent localization of a subset of mRNA to the endoplasmic reticulum. PLoS Biol. 2012;10:e1001336 pubmed publisher
    ..ER-bound polysomes, we identified putative mRNA receptors that may mediate this alternative mechanism, including p180, an abundant, positively charged membrane-bound protein...
  16. Naveen V, Hsiao C. NrdR Transcription Regulation: Global Proteome Analysis and Its Role in Escherichia coli Viability and Virulence. PLoS ONE. 2016;11:e0157165 pubmed publisher
    ..In parallel, studies on complementary expression of downregulated essential genes polA, eno and thiL showed partial rescue of the fitness defect caused by NrdR overexpression...
  17. Clémot M, Molla Herman A, Mathieu J, Huynh J, Dostatni N. The replicative histone chaperone CAF1 is essential for the maintenance of identity and genome integrity in adult stem cells. Development. 2018;145: pubmed publisher
    ..We depleted P180, the large subunit of CAF1, in germ cells and found that it was required in GSCs to maintain their identity...
  18. Premoli I, Rivolta D, Espenhahn S, Castellanos N, Belardinelli P, Ziemann U, et al. Characterization of GABAB-receptor mediated neurotransmission in the human cortex by paired-pulse TMS-EEG. Neuroimage. 2014;103:152-62 pubmed publisher
    ..LICI at baseline (i.e. pre-drug intake) was characterized by decreased P25, N45, N100 and P180 and increased P70 TEP components...
  19. Cuenca N, Fernández Sánchez L, Sauvé Y, Segura F, Martínez Navarrete G, Tamarit J, et al. Correlation between SD-OCT, immunocytochemistry and functional findings in an animal model of retinal degeneration. Front Neuroanat. 2014;8:151 pubmed publisher
    ..Pigmented rats heterozygous for the P23H mutation, with ages between P18 and P180 were studied. Function was assessed by means of optomotor testing and ERGs...
  20. Lin C, Lee H, Wu J, Tsai H. Short fish-origin DNA elements served as flanking sequences in a knockdown cloning vector enabling the generation of a functional siRNA molecule in mammalian cells and fish embryos. Biochem Biophys Res Commun. 2018;505:850-857 pubmed publisher
    ..3' UTR of GFP reporter cDNA driven by a cytomegalovirus promoter to obtain a plasmid containing gfp-IE-vegf-shRNA-polA. Upon microinjection of this plasmid into zebrafish embryos, we found that IE flanking sequences could effectively ..
  21. Spratlen M, Grau Perez M, Umans J, Yracheta J, Best L, Francesconi K, et al. Targeted metabolomics to understand the association between arsenic metabolism and diabetes-related outcomes: Preliminary evidence from the Strong Heart Family Study. Environ Res. 2019;168:146-157 pubmed publisher
    ..outcomes (HOMA2-IR, waist circumference, fasting plasma glucose) using metabolomic data from an OCM-specific and P180 metabolite panel measured in plasma, arsenic metabolism measured in urine, and HOMA2-IR and FPG measured in fasting ..
  22. Feldman A, Eder S, Felder T, Kedenko L, Paulweber B, Stadlmayr A, et al. Clinical and Metabolic Characterization of Lean Caucasian Subjects With Non-alcoholic Fatty Liver. Am J Gastroenterol. 2017;112:102-110 pubmed publisher
    ..The serum metabolome was assessed using the Metabolomics AbsoluteIDQ p180 kit (BIOCRATES Life Sciences)...
  23. Zamani Ahmadmahmudi M, Najafi A, Nassiri S. Reconstruction of canine diffuse large B-cell lymphoma gene regulatory network: detection of functional modules and hub genes. J Comp Pathol. 2015;152:119-30 pubmed publisher
    ..analysis showed E2F1, E2F4, PTEN, CDKN1A, PCNA, DKC1, MNAT1, NDUFB4, ATP5J, PRKDC, BRCA1, MYCN, RFC4 and POLA1 as the most important hub genes...
  24. Gayet Ageron A, Combescure C, Lautenschlager S, Ninet B, Perneger T. Comparison of Diagnostic Accuracy of PCR Targeting the 47-Kilodalton Protein Membrane Gene of Treponema pallidum and PCR Targeting the DNA Polymerase I Gene: Systematic Review and Meta-analysis. J Clin Microbiol. 2015;53:3522-9 pubmed publisher
    ..Comparisons of the performance of the two main targets are tpp47 and polA genes were done using meta-analysis...
  25. Truscott M, Raynal L, Premdas P, Goulet B, Leduy L, Bérubé G, et al. CDP/Cux stimulates transcription from the DNA polymerase alpha gene promoter. Mol Cell Biol. 2003;23:3013-28 pubmed
    ..Notwithstanding its mechanism of action, these results establish CDP/Cux as an important transcriptional regulator in the S phase. ..
  26. Furlan I, Bridi E, Amaral F, França F, Turssi C, Basting R. Effect of high- or low-concentration bleaching agents containing calcium and/or fluoride on enamel microhardness. Gen Dent. 2017;65:66-70 pubmed
    ..The high-concentration HP agents were Whiteness HP Maxx (35% HP), Whiteness HP Blue (35% HP, 2% calcium gluconate), Pola Office+ (37.5% HP, 5% potassium nitrate), and Opalescence Boost (38% HP, 1.1% fluoride ion, 3% potassium nitrate)...
  27. Li W, Ali F, Cai Q, Yao Z, Sun L, Lin W, et al. Quantitative proteomic analysis reveals that chemotaxis is involved in chlortetracycline resistance of Aeromonas hydrophila. J Proteomics. 2018;172:143-151 pubmed publisher
    ..Bioinformatics analysis showed that chemotaxis related proteins, such as CheA-2, CheR-3, CheW-2, EnvZ, PolA, FliS and FliG were down-regulated in addition to previously reported tricarboxylic acid cycle (TCA) related ..
  28. Lario S, Ramírez Lázaro M, Sanjuán Herráez D, Brunet Vega A, Pericay C, Gombau L, et al. Plasma sample based analysis of gastric cancer progression using targeted metabolomics. Sci Rep. 2017;7:17774 pubmed publisher
    ..phenylalanine metabolites were quantified using two complementary quantitative approaches: Biocrates AbsoluteIDQ®p180 kit and a LC-MS method designed for the analysis of 29 tryptophan pathway and phenylalanine metabolites...
  29. Palacios Abella J, Georgieva S, Mele S, Raga J, Isbert W, Kostadinova A, et al. Skoulekia erythrini n. sp. (Digenea: Aporocotylidae): a parasite of Pagellus erythrinus (L.) (Perciformes: Sparidae) from the western Mediterranean with an amendment of the generic diagnosis. Syst Parasitol. 2017;94:669-688 pubmed publisher
    ..Skoulekia meningialis is described from a new sparid host, Diplodus puntazzo (Walbaum), collected off Santa Pola, Spain. The new morphological data for the two Skoulekia spp. and a re-examination of three paratypes of S...
  30. Loguercio A, Servat F, Stanislawczuk R, Mena Serrano A, Rezende M, Prieto M, et al. Effect of acidity of in-office bleaching gels on tooth sensitivity and whitening: a two-center double-blind randomized clinical trial. Clin Oral Investig. 2017;21:2811-2818 pubmed publisher
    ..the tooth sensitivity (TS) and bleaching efficacy of two hydrogen peroxide gels with different pHs (acid pH [Pola Office, SDI] and the neutral pH [Pola Office+, SDI]) used for in-office bleaching...
  31. Diotti R, Kalan S, Matveyenko A, Loayza D. DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing. Mol Cancer Res. 2015;13:402-10 pubmed publisher
    ..Here, focus was paid to the catalytic (POLA1/p180) and accessory (POLA2/p68) subunits of the polymerase, and their mechanistic roles at telomeres...
  32. Infante Domínguez C, Sánchez Porro C, Ventosa A. Aquisalimonas lutea sp. nov., a moderately halophilic bacterium from a saltern. Int J Syst Evol Microbiol. 2015;65:1354-9 pubmed publisher
    ..halophilic and strictly aerobic bacterium, designated BA42AL-1(T), was isolated from water of a saltern of Santa Pola, Alicante, Spain. Strain BA42AL-1(T) grew in media containing 5-20% (w/v) salts (optimum 7.5% salts)...
  33. Rosenberg S, Ducray F, Alentorn A, Dehais C, Elarouci N, Kamoun A, et al. Machine Learning for Better Prognostic Stratification and Driver Gene Identification Using Somatic Copy Number Variations in Anaplastic Oligodendroglioma. Oncologist. 2018;23:1500-1510 pubmed publisher
    ..A cohort of 197 patients with anaplastic oligodendroglioma was collected as part of the French POLA network. Clinical, pathological, and molecular information was recorded...
  34. Gómez Marroquín M, Martin H, Pepper A, Girard M, Kidman A, Vallin C, et al. Stationary-Phase Mutagenesis in Stressed Bacillus subtilis Cells Operates by Mfd-Dependent Mutagenic Pathways. Genes (Basel). 2016;7: pubmed publisher
    ..Moreover, the mfd and polA mutants presented low but similar reversion frequencies compared to the parental strain...
  35. Melle C, Nasheuer H. Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase alpha-primase. Nucleic Acids Res. 2002;30:1493-9 pubmed
    ..The exonuclease activity of p53 as well as the elongation of a primer with a mispaired 3'-end was inhibited specifically by the anti-p53 monoclonal antibodies PAb240 and PAb421. ..
  36. Benoit J, Ayoub A, Rakic P. Transcriptomics of critical period of visual cortical plasticity in mice. Proc Natl Acad Sci U S A. 2015;112:8094-9 pubmed publisher
    ..the onset of the critical period of plasticity [postnatal day 5 (P5)], at its peak (P26), and at the mature stage (P180) and compare it with the prefrontal association area...
  37. Yamagami T, Matsukawa H, Tsunekawa S, Kawarabayasi Y, Ishino S, Ishino Y. A longer finger-subdomain of family A DNA polymerases found by metagenomic analysis strengthens DNA binding and primer extension abilities. Gene. 2016;576:690-5 pubmed publisher
    ..The corresponding regions of the polA gene for Taq polymerase were substituted with the metagenomic DNA gene fragments, and various chimeric DNA ..
  38. Premoli I, Király J, Müller Dahlhaus F, Zipser C, Rossini P, Zrenner C, et al. Short-interval and long-interval intracortical inhibition of TMS-evoked EEG potentials. Brain Stimul. 2018;11:818-827 pubmed publisher
    ..50 mg of the GABAB receptor agonist baclofen on SICI of TEPs. We found significant SICI of the N100 and P180 TEPs prior to drug intake. Diazepam reduced SICI of the N100 TEP, while baclofen enhanced it...
  39. Kenéz A, Koch C, Korst M, Kesser J, Eder K, Sauerwein H, et al. Different milk feeding intensities during the first 4 weeks of rearing dairy calves: Part 3: Plasma metabolomics analysis reveals long-term metabolic imprinting in Holstein heifers. J Dairy Sci. 2018;101:8446-8460 pubmed publisher
    ..Samples were subjected to a targeted metabolomics analysis using the AbsoluteIDQ p180 kit of Biocrates Life Science AG (Innsbruck, Austria)...
  40. Marsetic R. [Analysis of civil hospitals in Pola (Pula) through a century of town history (1842-1947)]. Acta Med Hist Adriat. 2014;12:275-314 pubmed
    ..The reasons for the explained status are mainly the result of financial and organisational problems that inevitably affected the quality of medical care available to the population. ..
  41. Hassan F, Gupta R. Novel Sequence Features of DNA Repair Genes/Proteins from Deinococcus Species Implicated in Protection from Oxidatively Generated Damage. Genes (Basel). 2018;9: pubmed publisher
    ..indels (CSIs) in the proteins UvrA1, UvrC, UvrD, UvsE, MutY, MutM, Nth, RecA, RecD, RecG, RecQ, RecR, RuvC, RadA, PolA, DnaE, LigA, GyrA and GyrB, that are uniquely shared by all/most Deinococcus homologs...
  42. Krasnikova L, Buzunov V, Solonovitch S. Radiation and non-radiation factors impact on development of cerebrovascular diseases in the Chornobyl clean-up workers. The epidemiological study results. Probl Radiac Med Radiobiol. 2013;:89-101 pubmed
    ..muzhskogo pola (8625 chelovek, v t.ch. 3623 chelovek s dozami vneshnego obluchenija vsego tela)...
  43. Chastagner A, Dugat T, Vourc h G, Verheyden H, Legrand L, Bachy V, et al. Multilocus sequence analysis of Anaplasma phagocytophilum reveals three distinct lineages with different host ranges in clinically ill French cattle. Vet Res. 2014;45:114 pubmed publisher
    ..animals (roe deer) and used multilocus sequence analysis on nine loci (ankA, msp4, groESL, typA, pled, gyrA, recG, polA, and an intergenic region) to characterize the genotypes of A. phagocytophilum present...
  44. Chiaramonte M, Moore C, Kincaid K, Kuchta R. Facile polymerization of dNTPs bearing unnatural base analogues by DNA polymerase alpha and Klenow fragment (DNA polymerase I). Biochemistry. 2003;42:10472-81 pubmed
    ..The implications of these results with respect to how polymerases discriminate between correct and incorrect dNTPs are discussed. ..
  45. Benyamini P, Webster P, Meyer D. Knockdown of p180 eliminates the terminal differentiation of a secretory cell line. Mol Biol Cell. 2009;20:732-44 pubmed publisher
    We have previously reported that the expression in yeast of an integral membrane protein (p180) of the endoplasmic reticulum (ER), isolated for its ability to mediate ribosome binding, is capable of inducing new membrane biogenesis and an ..
  46. Wu M, Zhao Z, Han Y. The changes of Proteome in MG-63 cells after induced by calcitonin gene-related peptide. Biochem Biophys Res Commun. 2014;453:648-52 pubmed publisher
    ..Mass spectrometry analysis identified 5 proteins, including ribosome binding protein p180 which is related to new synthetic protein's translocation and calcium-binding protein (HRNR Hornerin) that can ..
  47. Infante Dominguez C, Lawson P, Johnson C, Sánchez Porro C, Ventosa A. Fodinicurvata halophila sp. nov., a moderately halophilic bacterium from a marine saltern. Int J Syst Evol Microbiol. 2015;65:766-71 pubmed publisher
    ..moderately halophilic bacterium, designated strain BA45AL(T), was isolated from water of a saltern located in Santa Pola, Alicante, Spain. Cells were motile, and catalase- and oxidase-positive...
  48. Haid M, Muschet C, Wahl S, Römisch Margl W, Prehn C, Moller G, et al. Long-term stability of human plasma metabolites during storage at -80 °C. J Proteome Res. 2017;: pubmed publisher
    ..During a time period of five years, 1012 of the aliquots were measured with the Biocrates AbsoluteIDQ® p180 targeted-metabolomics assay at 193 time points...
  49. Wang C, Cheng Y, Liu B, Wang Y, Gong W, Qian Y, et al. Sensitive detection of Treponema pallidum DNA from the whole blood of patients with syphilis by the nested PCR assay. Emerg Microbes Infect. 2018;7:83 pubmed publisher
    ..In this study, a nested PCR method targeting the Tpp47 and polA genes (Tpp47-Tp-PCR and polA-Tp-PCR) was developed to detect TP-DNA in whole blood samples collected from 262 ..
  50. Lagrée A, Rouxel C, Kevin M, Dugat T, Girault G, Durand B, et al. Co-circulation of different A. phagocytophilum variants within cattle herds and possible reservoir role for cattle. Parasit Vectors. 2018;11:163 pubmed publisher
    ..The positive DNA samples underwent MLST at nine genetic markers (typA, ctrA, msp4, pleD, recG, polA, groEL, gyrA, and ankA)...
  51. Vaisman A, McDonald J, Noll S, Huston D, Loeb G, Goodman M, et al. Investigating the mechanisms of ribonucleotide excision repair in Escherichia coli. Mutat Res. 2014;761:21-33 pubmed publisher
    ..In vivo, umuC_Y11A-dependent mutagenesis changes significantly in polymerase-deficient, or proofreading-deficient polA strains, indicating a pivotal role for pol I in ribonucleotide excision repair (RER)...
  52. Su K, Lin L, Goodman S, Yen R, Wu C, Chang W, et al. DNA polymerase I proofreading exonuclease activity is required for endonuclease V repair pathway both in vitro and in vivo. DNA Repair (Amst). 2018;64:59-67 pubmed publisher
    ..while the polA-D424A strain, a pol I mutant defective in 3'-5' exonuclease, showed a high repair level similar to wild ..
  53. Dhungana S, Carlson J, Pathmasiri W, McRitchie S, Davis M, Sumner S, et al. Impact of a western diet on the ovarian and serum metabolome. Maturitas. 2016;92:134-142 pubmed publisher
    ..Targeted analysis was conducted using the Biocrates p180 kit and broad spectrum analysis was conducted using UPLC-TOF-MS, resulting in the detection of 3500 compound ions...
  54. Castell S, Krause G, Schmitt M, Pawlita M, Deleré Y, Obi N, et al. Feasibility and acceptance of cervicovaginal self-sampling within the German National Cohort (Pretest 2). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014;57:1270-6 pubmed publisher
    ..Human beta-globin and DNA polymerase alpha (PolA) sequences were used as positive controls for the detection of human DNA during HPV detection and STIP, ..
  55. Zhu Y, Zheng M, Song D, Ye L, Wang X. Global comparison of chromosome X genes of pulmonary telocytes with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes. J Transl Med. 2015;13:318 pubmed publisher
    ..Srpx2) and 23 down-regulated (Abcb7, Atf1, Ddx26b, Drp2, Fam122b, Gyk, Irak1, Lamp2, Mecp2, Ndufb11, Ogt, Pdha1, Pola1, Rab9, Rbmx2, Rhox9, Thoc2, Vbp1, Dkc1, Nkrf, Piga, Tmlhe and Tsr2), as compared with other cells...
  56. Gomariz M, Martínez García M, Santos F, Constantino M, Meseguer I, Antón J. Retinal-binding proteins mirror prokaryotic dynamics in multipond solar salterns. Environ Microbiol. 2015;17:514-26 pubmed publisher
    Microbial opsin (i.e. retinal-binding protein) dynamics has been studied along a salinity gradient in Santa Pola solar salterns (Alicante, Spain) by using culture-independent approaches and statistical analyses...
  57. Tanvir R, Sajid I, Hasnain S, Kulik A, Grond S. Rare actinomycetes Nocardia caishijiensis and Pseudonocardia carboxydivorans as endophytes, their bioactivity and metabolites evaluation. Microbiol Res. 2016;185:22-35 pubmed publisher
    ..The genotoxicity testing revealed a 20 mm zone of inhibition against the polA mutant strain E. coli K-12 AB 3027 suggesting damage to the DNA and polA genes...
  58. Opie G, Sidhu S, Rogasch N, Ridding M, Semmler J. Cortical inhibition assessed using paired-pulse TMS-EEG is increased in older adults. Brain Stimul. 2018;11:545-557 pubmed publisher
    ..Despite this, N45 amplitude was increased in older adults and both N100 and P180 showed altered spatial distributions...
  59. Paglia G, Del Greco F, Sigurdsson B, Rainer J, Volani C, Hicks A, et al. Influence of collection tubes during quantitative targeted metabolomics studies in human blood samples. Clin Chim Acta. 2018;486:320-328 pubmed publisher
    ..We analyzed 189 metabolites using the same protocol for quantitative targeted metabolomics (LC-MS/MS AbsoluteIDQ p180 Kit Biocrates) in three types of samples, serum, plasma EDTA and citrate, of 80 subjects from the Cooperative ..
  60. Carlos N, Bridi E, Amaral F, França F, Turssi C, Basting R. Efficacy of Home-use Bleaching Agents Delivered in Customized or Prefilled Disposable Trays: A Randomized Clinical Trial. Oper Dent. 2017;42:30-40 pubmed publisher
    ..5% HP (Pola Day) and 10% CP both delivered in customized trays (Opalescence PF 10%)...
  61. de la Barca J, Boueilh T, Simard G, Boucret L, Ferré L Hotellier V, Tessier L, et al. Targeted metabolomics reveals reduced levels of polyunsaturated choline plasmalogens and a smaller dimethylarginine/arginine ratio in the follicular fluid of patients with a diminished ovarian reserve. Hum Reprod. 2017;32:2269-2278 pubmed publisher
    ..using high-performance liquid chromatography coupled with tandem mass spectrometry, and the Biocrates Absolute IDQ p180 kit...
  62. Li W, Ali F, Cai Q, Yao Z, Sun L, Lin W, et al. Reprint of: Quantitative proteomic analysis reveals that chemotaxis is involved in chlortetracycline resistance of Aeromonas hydrophila. J Proteomics. 2018;180:138-146 pubmed publisher
    ..Bioinformatics analysis showed that chemotaxis related proteins, such as CheA-2, CheR-3, CheW-2, EnvZ, PolA, FliS and FliG were down-regulated in addition to previously reported tricarboxylic acid cycle (TCA) related ..
  63. Pinilla G, Campos L, Duran A, Navarrete J, Munoz L. Detección de Treponema pallidum subespecie pallidum para el diagnóstico de sífilis congénita mediante reacción en cadena de la polimerasa anidada. Biomedica. 2018;38:128-35 pubmed publisher
    ..Materiales y métodos. Mediante PCR convencional y anidada, se amplificaron tres genes diana (polA, 16S ADNr y TpN47) y se confirmaron los productos de amplificación de los genes TpN47 y polA por secuenciación...
  64. Anjum R, Krakat N. Genotoxicity assessments of alluvial soil irrigated with wastewater from a pesticide manufacturing industry. Environ Monit Assess. 2015;187:638 pubmed publisher
    ..A maximum survival of 15.2% and decline of colony-forming units (CFUs) was observed in polA mutants of DNA repair-defective E. coli K-12 strains when hexane was used as solvent...
  65. Santana M, Bridi E, Navarro R, de Lima C, Fernandes A, do Amaral F, et al. Dental bleaching with ozone: effects on color and enamel microhardness. Acta Odontol Latinoam. 2016;29:68-75 pubmed
    ..5% hydrogen peroxide (Pola Office+/ SDI); PLA - placebo gel; O3 - ozone; and O2 - oxygen...
  66. Nishida C, Reinhard P, Linn S. DNA repair synthesis in human fibroblasts requires DNA polymerase delta. J Biol Chem. 1988;263:501-10 pubmed
  67. Schmidt J, Fensom G, Rinaldi S, Scalbert A, Appleby P, Achaintre D, et al. Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition. BMC Med. 2017;15:122 pubmed publisher
    ..amines, glycerophospholipids, hexose and sphingolipids) were measured using targeted mass spectrometry (AbsoluteIDQ p180 Kit) and compared between 1077 prostate cancer cases and 1077 matched controls...
  68. Lee A, Jang H, Ra M, Choi Y, Lee H, Park J, et al. Prediction of future risk of insulin resistance and metabolic syndrome based on Korean boy's metabolite profiling. Obes Res Clin Pract. 2015;9:336-45 pubmed publisher
    ..5±0.4 years) from the Korean Child Obesity Cohort Study using the AbsoluteIDQ™ p180 Kit...
  69. Park J, Kim Y, Lee H. Involvement of the NADH oxidase-encoding noxA gene in oxidative stress responses in Corynebacterium glutamicum. Appl Microbiol Biotechnol. 2015;99:1363-74 pubmed publisher
    ..A noxA-deleted mutant strain and a strain overexpressing the noxA gene (P180-noxA) were established, and these strains were found to exhibit defective cell growth...
  70. Haddrick M, Lear A, Cann A, Heaphy S. Evidence that a kissing loop structure facilitates genomic RNA dimerisation in HIV-1. J Mol Biol. 1996;259:58-68 pubmed
    ..In contrast sequences involved in forming a kissing loop complex are not absolutely required, but are important in forming a stable HIV-1 RNA dimer. ..
  71. Bermudez V, Farina A, Raghavan V, Tappin I, Hurwitz J. Studies on human DNA polymerase epsilon and GINS complex and their role in DNA replication. J Biol Chem. 2011;286:28963-77 pubmed publisher
    ..We suggest that reduction in the level of Pol ? may be less deleterious because of its collision-and-release role in lagging strand synthesis. ..
  72. Corona G, Cannizzaro R, Miolo G, Caggiari L, De Zorzi M, Repetto O, et al. Use of Metabolomics as a Complementary Omic Approach to Implement Risk Criteria for First-Degree Relatives of Gastric Cancer Patients. Int J Mol Sci. 2018;19: pubmed publisher
    ..Serum metabolomic profiles were performed with tandem mass spectrometry using the Biocrates AbsoluteIDQ p180 kit. The initial cohort (training set) consisted of n = 49 GC patients and n = 37 FDR...
  73. van Roekel E, Trijsburg L, Assi N, Carayol M, Achaintre D, Murphy N, et al. Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort. Nutrients. 2018;10: pubmed publisher
    ..Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets...
  74. Toledo J, Arnold M, Kastenmüller G, Chang R, Baillie R, Han X, et al. Metabolic network failures in Alzheimer's disease: A biochemical road map. Alzheimers Dement. 2017;13:965-984 pubmed publisher
    ..199 control, 356 mild cognitive impairment, and 175 AD participants) were analyzed using the AbsoluteIDQ-p180 kit. Performance was validated in blinded replicates, and values were medication adjusted...
  75. Eckert K, Kunkel T. Fidelity of DNA synthesis catalyzed by human DNA polymerase alpha and HIV-1 reverse transcriptase: effect of reaction pH. Nucleic Acids Res. 1993;21:5212-20 pubmed
    ..The HIV-1 RT results are in agreement with our previous hypothesis that the observed increase in polymerase fidelity at low pH results from a decreased efficiency of continuing DNA synthesis from premutational DNA intermediates. ..
  76. Bieńkowski P, Cała P, Zubrzak B. [Optimization of measurement methods for a multi-frequency electromagnetic field from mobile phone base station using broadband EMF meter]. Med Pr. 2015;66:701-12 pubmed publisher
    ..W artykule przedstawiono charakterystykę źródła pola elektromagnetycznego (PEM), jakim jest stacja bazowa (base station – BS) telefonii komórkowej...
  77. Castro R, Águas M, Batista T, Araújo C, Mansinho K, Pereira F. Detection of Treponema pallidum Sp. Pallidum DNA in Cerebrospinal Fluid (CSF) by Two PCR Techniques. J Clin Lab Anal. 2016;30:628-32 pubmed publisher
    ..Two PCR techniques (47-PCR, polA-PCR) were used to detect T. pallidum DNA...
  78. Evanics F, Maurmann L, Yang W, Bose R. Nuclear magnetic resonance structures of the zinc finger domain of human DNA polymerase-alpha. Biochim Biophys Acta. 2003;1651:163-71 pubmed
    ..These results are discussed in the context of other eukaryotic and prokaryotic DNA polymerases belonging to the polymerase B family. ..
  79. Zhang Y, Baranovskiy A, Tahirov T, Pavlov Y. The C-terminal domain of the DNA polymerase catalytic subunit regulates the primase and polymerase activities of the human DNA polymerase ?-primase complex. J Biol Chem. 2014;289:22021-34 pubmed publisher
    ..second subunit (p180C-p70) stimulated primase activity, whereas the whole catalytically active heterodimer of pol? (p180?N-p70) inhibited RNA synthesis by primase...
  80. Narvik J, Vanaveski T, Innos J, Philips M, Ottas A, Haring L, et al. Metabolic profile associated with distinct behavioral coping strategies of 129Sv and Bl6 mice in repeated motility test. Sci Rep. 2018;8:3405 pubmed publisher
    ..amino acids, biogenic amines, hexoses, glycerophospholipids and sphingolipids) were determined with AbsoluteIDQ p180 kit. Results of the metabolomic study revealed prominent peculiarities between strains in two different conditions...
  81. Yoon D, Cha D, Alfhili M, Keiper B, Lee M. Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline. FEBS J. 2018;285:2590-2604 pubmed publisher
    ..Here, we show that subunits (POLA-1, DIV-1, PRI-1, and PRI-2) of the DNA polymerase alpha-primase complex are required for germ cell proliferation in ..
  82. Han T, Goralski M, Capota E, Padrick S, Kim J, Xie Y, et al. The antitumor toxin CD437 is a direct inhibitor of DNA polymerase ?. Nat Chem Biol. 2016;12:511-5 pubmed publisher
    ..We used a forward-genetic strategy to discover mutations in POLA1 that coincide with CD437 resistance (POLA1(R))...
  83. ter Braack E, Koopman A, van Putten M. Early TMS evoked potentials in epilepsy: A pilot study. Clin Neurophysiol. 2016;127:3025-3032 pubmed publisher
    ..0073). For right motor cortex stimulation, the P180 was larger in amplitude in epilepsy patients than in healthy subjects (p=0.006)...
  84. Alentorn A, Dehais C, Ducray F, Carpentier C, Mokhtari K, Figarella Branger D, et al. Allelic loss of 9p21.3 is a prognostic factor in 1p/19q codeleted anaplastic gliomas. Neurology. 2015;85:1325-31 pubmed publisher
    ..The prognostic value of 9p allelic loss was investigated using a French nation-wide prospective registry, POLA (prise en charge des tumeurs oligodendrogliales anaplasiques) and high-density single nucleotide polymorphism ..
  85. Mamrot P, Mariańska M, Aniołczyk H, Politański P. [Electromagnetic fields in the vicinity of DECT cordless telephones and mobile phones]. Med Pr. 2015;66:803-14 pubmed publisher
    ..urządzeń było poznanie poziomu natężenia pola elektrycznego z uwzględnieniem różnego trybu pracy (rozmowa głosowa GSM (global system for mobile ..
  86. da Rosa Nogueira T, Alexandrino L, de Lima Gomes Y, de Melo Alencar C, Alves E, Silva C. An in situ Evaluation of Bioactives on the Morphology of Bleached Enamel. J Contemp Dent Pract. 2016;17:192-7 pubmed
    ..The POLA-positive control has only been bleached...
  87. Pearson B, Nasheuer H, Wang T. Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells. Mol Cell Biol. 1991;11:2081-95 pubmed
    ..No single sequence element could be shown to confer serum inducibility. Rather, multiple sequence elements appear to mediate the full serum response. ..
  88. Pollok S, Stoepel J, Bauerschmidt C, Kremmer E, Nasheuer H. Regulation of eukaryotic DNA replication at the initiation step. Biochem Soc Trans. 2003;31:266-9 pubmed
    ..New phosphorylation-specific antibodies specifically recognize the phosphorylated subunit, p68, of the four subunit DNA polymerase alpha-primase and show that the phosphorylated polypeptide is exclusively nuclear. ..
  89. Warren E, Huang H, Fanning E, Chazin W, Eichman B. Physical interactions between Mcm10, DNA, and DNA polymerase alpha. J Biol Chem. 2009;284:24662-72 pubmed publisher
    ..ID) and C-terminal (CTD) domains of Mcm10 physically interact with both single-stranded (ss) DNA and the catalytic p180 subunit of pol alpha. However, the mechanism by which Mcm10 interacts with pol alpha on and off DNA is unclear...
  90. Hansen S, Ehlers N, Zhu S, Thomsen M, Nielsen R, Liu D, et al. The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells. BMC Genomics. 2016;17:442 pubmed publisher
    ..Of these genes, CASK, POLA1, PRDX4, MED14 and PIGA were highly prioritized by the applied network-based gene ranking approach...
  91. Alebic Juretic A. Sanitary conditions in the Austrohungarian war harbour Pola (Pula, Croatia) in 1916-17: foundation of the Hygienic Institute. Acta Med Hist Adriat. 2017;15:67-82 pubmed
    Since 1850 the town of Pola (today Pula, Croatia) underwent big changes and growth due to its transformation into the principal military port of Austrian-Hungarian Empire...
  92. Cui X, Zhang H, Ilan L, Liu A, Kharchuk I, Palazzo A. mRNA encoding Sec61β, a tail-anchored protein, is localized on the endoplasmic reticulum. J Cell Sci. 2015;128:3398-410 pubmed publisher
    ..Our data suggests that this process is independent of p180 (also known as RRBP1), a known mRNA receptor on the ER, and the transmembrane domain recognition complex (TRC) ..