podoplanin

Summary

Gene Symbol: podoplanin
Description: podoplanin
Alias: AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A, podoplanin, PA2.26 antigen, T1-alpha, glycoprotein 36, glycoprotein, 36-KD, hT1alpha-1, hT1alpha-2, lung type I cell membrane associated glycoprotein, lung type-I cell membrane-associated glycoprotein (T1A-2)
Species: human
Products:     podoplanin

Top Publications

  1. Nakazawa Y, Sato S, Naito M, Kato Y, Mishima K, Arai H, et al. Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis. Blood. 2008;112:1730-9 pubmed publisher
    ..Because HT1080 cells express the metastasis-promoting, platelet aggregation-inducing factor Aggrus/podoplanin on their surface, we examined the relationship between CD9 and Aggrus...
  2. Grimaldo S, Garcia M, Zhang H, Chen L. Specific role of lymphatic marker podoplanin in retinal pigment epithelial cells. Lymphology. 2010;43:128-34 pubmed
    b>Podoplanin is a small transmembrane glycoprotein widely known to be a marker for lymphatic endothelial cells...
  3. Tsuneki M, Maruyama S, Yamazaki M, Essa A, Abe T, Babkair H, et al. Podoplanin is a novel myoepithelial cell marker in pleomorphic adenoma and other salivary gland tumors with myoepithelial differentiation. Virchows Arch. 2013;462:297-305 pubmed publisher
    The expression of podoplanin, one of the representative immunohistochemical markers for lymphatic endothelium, is upregulated in various kinds of cancers...
  4. Pula B, Jethon A, Piotrowska A, Gomulkiewicz A, Owczarek T, Calik J, et al. Podoplanin expression by cancer-associated fibroblasts predicts poor outcome in invasive ductal breast carcinoma. Histopathology. 2011;59:1249-60 pubmed publisher
    It has recently been shown that podoplanin, a mucin-type glycoprotein, is expressed by cancer cells and cancer-associated fibroblasts (CAFs), and promotes cancer cell migration and invasiveness...
  5. Schacht V, Dadras S, Johnson L, Jackson D, Hong Y, Detmar M. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol. 2005;166:913-21 pubmed
    The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and podoplanin deficiency results in congenital lymphedema and ..
  6. Ekwall A, Eisler T, Anderberg C, Jin C, Karlsson N, Brisslert M, et al. The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis. Arthritis Res Ther. 2011;13:R40 pubmed publisher
    ..The glycoprotein podoplanin is upregulated in the invasive front of several human cancers and has been associated with epithelial-..
  7. Mishima K, Kato Y, Kaneko M, Nishikawa R, Hirose T, Matsutani M. Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression. Acta Neuropathol. 2006;111:483-8 pubmed
    b>Podoplanin (aggrus) is a mucin-like transmembrane sialoglycoprotein that is expressed on lymphatic endothelial cells...
  8. Uhrin P, Zaujec J, Breuss J, Olcaydu D, Chrenek P, Stockinger H, et al. Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood. 2010;115:3997-4005 pubmed publisher
    ..establishment and maintenance of distinct blood and lymphatic systems, primarily by mediating proper function of podoplanin. Here, we show that this separation process critically involves platelet activation by podoplanin...
  9. Ochoa Alvarez J, Krishnan H, Shen Y, Acharya N, Han M, McNulty D, et al. Plant lectin can target receptors containing sialic acid, exemplified by podoplanin, to inhibit transformed cell growth and migration. PLoS ONE. 2012;7:e41845 pubmed publisher
    ..For example, the extracellular domain of the mucin receptor podoplanin (PDPN) is highly O-glycosylated with ?2,3-sialic acid linked to galactose...

More Information

Publications66

  1. Hultgård Ekwall A, Mayerl C, Rubin K, Wick G, Rask Andersen H. An interstitial network of podoplanin-expressing cells in the human endolymphatic duct. J Assoc Res Otolaryngol. 2006;7:38-47 pubmed
    ..Here we report that the periductal CT is populated by two distinct cell phenotypes; one expressing podoplanin, a protein otherwise found on lymph endothelia and on epithelia involved in fluid fluxes, and a second ..
  2. Braun M, Flucke U, Debald M, Walgenbach Bruenagel G, Walgenbach K, Höller T, et al. Detection of lymphovascular invasion in early breast cancer by D2-40 (podoplanin): a clinically useful predictor for axillary lymph node metastases. Breast Cancer Res Treat. 2008;112:503-11 pubmed publisher
    ..Further prospective studies are needed to prove the clinical impact of D2-40. ..
  3. Kato Y, Fujita N, Kunita A, Sato S, Kaneko M, Osawa M, et al. Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors. J Biol Chem. 2003;278:51599-605 pubmed
    ..We have previously characterized the platelet aggregation-inducing sialoglycoprotein (Aggrus/gp44) overexpressed on the surface of tumor cells...
  4. Yurrita M, Fernández Muñoz B, del Castillo G, Martín Villar E, Renart J, Quintanilla M. Podoplanin is a substrate of presenilin-1/?-secretase. Int J Biochem Cell Biol. 2014;46:68-75 pubmed publisher
    b>Podoplanin (PDPN) is a mucin-like transmembrane glycoprotein that plays an important role in development and cancer...
  5. Rodrigo J, Garcia Carracedo D, González M, Mancebo G, Fresno M, García Pedrero J. Podoplanin expression in the development and progression of laryngeal squamous cell carcinomas. Mol Cancer. 2010;9:48 pubmed publisher
    b>Podoplanin expression is attracting interest as a marker for cancer diagnosis and prognosis...
  6. Yamanashi T, Nakanishi Y, Fujii G, Akishima Fukasawa Y, Moriya Y, Kanai Y, et al. Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma. Oncology. 2009;77:53-62 pubmed publisher
    ..We investigated the clinicopathological significance of podoplanin expression in stromal fibroblasts in patients with colorectal cancer (CRC)...
  7. Kawaguchi H, El Naggar A, Papadimitrakopoulou V, Ren H, Fan Y, Feng L, et al. Podoplanin: a novel marker for oral cancer risk in patients with oral premalignancy. J Clin Oncol. 2008;26:354-60 pubmed publisher
    ..We have shown that podoplanin, a lymphatic endothelial marker, is highly expressed in oral cancer and some oral premalignancies...
  8. Dumoff K, Chu C, Harris E, Holtz D, Xu X, Zhang P, et al. Low podoplanin expression in pretreatment biopsy material predicts poor prognosis in advanced-stage squamous cell carcinoma of the uterine cervix treated by primary radiation. Mod Pathol. 2006;19:708-16 pubmed
    ..We have recently found that low podoplanin immunoreactivity in cervix carcinoma correlated with the presence of lymphatic invasion and nodal metastasis...
  9. Wicki A, Christofori G. The potential role of podoplanin in tumour invasion. Br J Cancer. 2007;96:1-5 pubmed
    b>Podoplanin is a small mucin-like transmembrane protein, widely expressed in various specialised cell types throughout the body. Here, we revisit the mechanism of podoplanin-mediated tumour invasion...
  10. Suzuki Inoue K, Kato Y, Inoue O, Kaneko M, Mishima K, Yatomi Y, et al. Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. J Biol Chem. 2007;282:25993-6001 pubmed
    b>Podoplanin (aggrus), a transmembrane sialoglycoprotein, is involved in tumor cell-induced platelet aggregation, tumor metastasis, and lymphatic vessel formation...
  11. Atsumi N, Ishii G, Kojima M, Sanada M, Fujii S, Ochiai A. Podoplanin, a novel marker of tumor-initiating cells in human squamous cell carcinoma A431. Biochem Biophys Res Commun. 2008;373:36-41 pubmed publisher
    ..Using the human SCC cell line A431, we found that, as a paradigm of cancer stem cells: (1) podoplanin(+) cells generate both podoplanin(+) and podoplanin(-) cells; (2) podoplanin(-) cells rarely generate podoplanin(..
  12. Kaneko M, Kato Y, Kunita A, Fujita N, Tsuruo T, Osawa M. Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells. J Biol Chem. 2004;279:38838-43 pubmed
    Aggrus, also called T1alpha and podoplanin, is a novel platelet aggregation-inducing factor that is expressed in various carcinoma cells...
  13. Martín Villar E, Yurrita M, Fernández Muñoz B, Quintanilla M, Renart J. Regulation of podoplanin/PA2.26 antigen expression in tumour cells. Involvement of calpain-mediated proteolysis. Int J Biochem Cell Biol. 2009;41:1421-9 pubmed publisher
    b>Podoplanin/PA2.26 antigen is a small transmembrane mucin expressed in different types of cancer where it is associated with increased cell migration, invasiveness and metastasis...
  14. Yu H, Pinkus G, Hornick J. Diffuse membranous immunoreactivity for podoplanin (D2-40) distinguishes primary and metastatic seminomas from other germ cell tumors and metastatic neoplasms. Am J Clin Pathol. 2007;128:767-75 pubmed
    b>Podoplanin has been shown to be expressed in primary germ cell tumors (GCTs), with conflicting results regarding its specificity...
  15. Xu Y, Ogose A, Kawashima H, Hotta T, Ariizumi T, Li G, et al. High-level expression of podoplanin in benign and malignant soft tissue tumors: immunohistochemical and quantitative real-time RT-PCR analysis. Oncol Rep. 2011;25:599-607 pubmed publisher
    b>Podoplanin is a 38 kDa mucin-type transmembrane glycoprotein that was first identified in rat glomerular epithelial cells (podocytes). It is expressed in normal lymphatic endothelium, but is absent from vascular endothelial cells...
  16. Navarro A, Perez R, Rezaiekhaligh M, Mabry S, Ekekezie I. Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42. Am J Physiol Lung Cell Mol Physiol. 2011;300:L32-42 pubmed publisher
    We have shown previously that T1?/podoplanin is required for capillary tube formation by human lung microvascular lymphatic endothelial cells (HMVEC-LLy) and that cells with decreased podoplanin expression fail to properly activate the ..
  17. Suzuki H, Onimaru M, Yonemitsu Y, Maehara Y, Nakamura S, Sueishi K. Podoplanin in cancer cells is experimentally able to attenuate prolymphangiogenic and lymphogenous metastatic potentials of lung squamoid cancer cells. Mol Cancer. 2010;9:287 pubmed publisher
    b>Podoplanin, a mucin-like transmembrane glycoprotein, is reportedly expressed in a variety of malignant cells and is generally regarded as a factor for promoting tumor progression in conventional studies...
  18. Martín Villar E, Fernández Muñoz B, Parsons M, Yurrita M, Megias D, Perez Gomez E, et al. Podoplanin associates with CD44 to promote directional cell migration. Mol Biol Cell. 2010;21:4387-99 pubmed publisher
    b>Podoplanin is a transmembrane glycoprotein up-regulated in different human tumors, especially those derived from squamous stratified epithelia (SCCs)...
  19. Kreppel M, Scheer M, Drebber U, Ritter L, Zoller J. Impact of podoplanin expression in oral squamous cell carcinoma: clinical and histopathologic correlations. Virchows Arch. 2010;456:473-82 pubmed publisher
    ..Recent studies suggest an impact of podoplanin expression on metastatic spread to the cervical lymph nodes...
  20. Schoppmann S, Jesch B, Riegler M, Maroske F, Schwameis K, Jomrich G, et al. Podoplanin expressing cancer associated fibroblasts are associated with unfavourable prognosis in adenocarcinoma of the esophagus. Clin Exp Metastasis. 2013;30:441-6 pubmed publisher
    Overexpression of the mucin-type sialoglycoprotein podoplanin in cancer associated fibroblasts (CAFs) was recently shown to be associated with tumor progression, metastasis and poor prognosis in lung and breast cancer...
  21. Navarro A, Perez R, Rezaiekhaligh M, Mabry S, Ekekezie I. T1alpha/podoplanin is essential for capillary morphogenesis in lymphatic endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2008;295:L543-51 pubmed publisher
    ..Mice lacking T1alpha/podoplanin, a lymphatic endothelial cell transmembrane protein, have malformed lymphatic vasculature with lymphedema at ..
  22. Martín Villar E, Scholl F, Gamallo C, Yurrita M, Muñoz Guerra M, Cruces J, et al. Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. Int J Cancer. 2005;113:899-910 pubmed
    We report the full cDNA sequence encoding the human homologue of murine PA2.26 (T1alpha-2, podoplanin), a small mucin-type transmembrane glycoprotein originally identified as a cell-surface antigen induced in keratinocytes during mouse ..
  23. Rahadiani N, Ikeda J, Makino T, Tian T, Qiu Y, Mamat S, et al. Tumorigenic role of podoplanin in esophageal squamous-cell carcinoma. Ann Surg Oncol. 2010;17:1311-23 pubmed publisher
    b>Podoplanin, a mucin-type transmembrane glycoprotein, is thought to be one of the cancer stem cell markers for squamous-cell carcinoma of the vulva...
  24. Kunita A, Kashima T, Ohazama A, Grigoriadis A, Fukayama M. Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma. Am J Pathol. 2011;179:1041-9 pubmed publisher
    b>Podoplanin is a type-I transmembrane sialomucin-like protein, which is expressed in a wide range of cell types and is involved in platelet aggregation and tumor metastasis...
  25. Kerjaschki D, Regele H, Moosberger I, Nagy Bojarski K, Watschinger B, Soleiman A, et al. Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates. J Am Soc Nephrol. 2004;15:603-12 pubmed
    ..on human renal transplant biopsies using antibodies to the lymphatic endothelial marker protein podoplanin. Nodular infiltrates are constantly associated with newly formed, Ki-67-expressing lymphatic vessels and contain ..
  26. Chao Y, Chuang W, Yeh C, Wu Y, Liu Y, Hsieh M, et al. Prognostic significance of high podoplanin expression after chemoradiotherapy in esophageal squamous cell carcinoma patients. J Surg Oncol. 2012;105:183-8 pubmed publisher
    The correlation between high tumor podoplanin (PP) immunoreactivity and poor outcome in patients with non-chemoradiotherapy(CRT) pretreated upper aerodigestive tract squamous cell carcinoma (SCC) has been reported recently...
  27. Ito T, Ishii G, Nagai K, Nagano T, Kojika M, Murata Y, et al. Low podoplanin expression of tumor cells predicts poor prognosis in pathological stage IB squamous cell carcinoma of the lung, tissue microarray analysis of 136 patients using 24 antibodies. Lung Cancer. 2009;63:418-24 pubmed publisher
    ..0086 and p=0.0091, respectively). The univariate analysis for immunohistochemical staining showed that the podoplanin-negative group had a shorter OS time and RFS time than the podoplanin-positive group (p=0.0106 and p=0...
  28. Takagi S, Sato S, Oh hara T, Takami M, Koike S, Mishima Y, et al. Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2. PLoS ONE. 2013;8:e73609 pubmed publisher
    The platelet aggregation-inducing factor Aggrus, also known as podoplanin, is frequently upregulated in several types of tumors and enhances hematogenous metastasis by interacting with and activating the platelet receptor CLEC-2...
  29. Lowe K, Navarro Nuñez L, Watson S. Platelet CLEC-2 and podoplanin in cancer metastasis. Thromb Res. 2012;129 Suppl 1:S30-7 pubmed publisher
    ..The sialyated membrane glycoprotein podoplanin is found on the leading edge of tumour cells and is thought to influence their migratory and invasive properties...
  30. Braun N, Alscher D, Fritz P, Edenhofer I, Kimmel M, Gaspert A, et al. Podoplanin-positive cells are a hallmark of encapsulating peritoneal sclerosis. Nephrol Dial Transplant. 2011;26:1033-41 pubmed publisher
    ..b>Podoplanin is expressed by mesothelial cells and lymphatic vessels, which are involved in inflammatory reactions in the ..
  31. Cueni L, Hegyi I, Shin J, Albinger Hegyi A, Gruber S, Kunstfeld R, et al. Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin. Am J Pathol. 2010;177:1004-16 pubmed publisher
    The membrane glycoprotein podoplanin is expressed by several types of human cancers and might be associated with their malignant progression. Its exact biological function and molecular targets are unclear, however...
  32. Kitano H, Kageyama S, Hewitt S, Hayashi R, Doki Y, Ozaki Y, et al. Podoplanin expression in cancerous stroma induces lymphangiogenesis and predicts lymphatic spread and patient survival. Arch Pathol Lab Med. 2010;134:1520-7 pubmed publisher
    b>Podoplanin is a mucin-type glycoprotein and a lymphatic endothelial marker. Immunohistochemical staining for podoplanin is currently used as a routine pathologic diagnosis tool in Japan to identify lymphatic invasion of cancer cells...
  33. Kawase A, Ishii G, Nagai K, Ito T, Nagano T, Murata Y, et al. Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma. Int J Cancer. 2008;123:1053-9 pubmed publisher
    Recent studies have reported increased podoplanin expression by cancer cells and stromal cells, but little is known about its expression and biological significance in adenocarcinoma of the lung...
  34. Ozaki Y, Suzuki Inoue K, Inoue O. Novel interactions in platelet biology: CLEC-2/podoplanin and laminin/GPVI. J Thromb Haemost. 2009;7 Suppl 1:191-4 pubmed publisher
    ..We found that CLEC-2 is the receptor for podoplanin, a sialoglycoprotein implicated in tumor-induced platelet aggregation and tumor metastasis...
  35. Cueni L, Chen L, Zhang H, Marino D, Huggenberger R, Alitalo A, et al. Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin. Blood. 2010;116:4376-84 pubmed publisher
    b>Podoplanin is a small transmembrane protein required for development and function of the lymphatic vascular system. To investigate the effects of interfering with its function, we produced an Fc fusion protein of its ectodomain...
  36. Cortez M, Nicoloso M, Shimizu M, Rossi S, Gopisetty G, Molina J, et al. miR-29b and miR-125a regulate podoplanin and suppress invasion in glioblastoma. Genes Chromosomes Cancer. 2010;49:981-90 pubmed publisher
    ..Recently, it was demonstrated that podoplanin membrane sialo-glycoprotein encoded by PDPN gene is over-expressed and related to cellular invasion in ..
  37. Christou C, Pearce A, Watson A, Mistry A, Pollitt A, Fenton May A, et al. Renal cells activate the platelet receptor CLEC-2 through podoplanin. Biochem J. 2008;411:133-40 pubmed publisher
    ..The transmembrane protein podoplanin was identified on HEK-293T cells and was demonstrated to mediate both binding of HEK-293T cells to CLEC-2 and ..
  38. Hansen T, Katenkamp K, Bittinger F, Kirkpatrick C, Katenkamp D. D2-40 labeling in lymphangiomyoma/lymphangiomyomatosis of the soft tissue: further evidence of lymphangiogenic tumor histogenesis. Virchows Arch. 2007;450:449-53 pubmed
    ..5 years) for immunohistochemical labeling with a monoclonal antibody against podoplanin (D2-40), which is specific for lymphatic endothelial lining...
  39. Osada M, Inoue O, Ding G, Shirai T, Ichise H, Hirayama K, et al. Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells. J Biol Chem. 2012;287:22241-52 pubmed publisher
    ..An endogenous ligand for CLEC-2, podoplanin, is expressed in lymphatic endothelial cells (LECs)...
  40. Mishima K, Kato Y, Kaneko M, Nakazawa Y, Kunita A, Fujita N, et al. Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma. Acta Neuropathol. 2006;111:563-8 pubmed
    b>Podoplanin, a mucin-like transmembrane sialoglycoprotein, promotes platelet aggregation and may be involved in cancer cell migration, invasion, metastasis, and malignant progression...
  41. Yu H, Gibson J, Pinkus G, Hornick J. Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors. Am J Clin Pathol. 2007;128:776-82 pubmed
    b>Podoplanin, recognized by monoclonal antibody D2-40, may be a useful marker for follicular dendritic cell (FDC) tumors...
  42. Zimmer G, Oeffner F, von Messling V, Tschernig T, Gröness H, Klenk H, et al. Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. Biochem J. 1999;341 ( Pt 2):277-84 pubmed
    ..transfected with the cDNA clone directed the cell-surface expression of a 36-kDa O-glycosylated sialoglycoprotein, gp36, and two minor isoforms of 28 and 70 kDa...
  43. Fernández Muñoz B, Yurrita M, Martín Villar E, Carrasco Ramirez P, Megias D, Renart J, et al. The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition. Int J Biochem Cell Biol. 2011;43:886-96 pubmed publisher
    b>Podoplanin is a transmembrane glycoprotein that is upregulated in cancer and was reported to induce an epithelial-mesenchymal transition (EMT) in MDCK cells...
  44. Wicki A, Lehembre F, Wick N, Hantusch B, Kerjaschki D, Christofori G. Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell. 2006;9:261-72 pubmed
    The expression of podoplanin, a small mucin-like protein, is upregulated in the invasive front of a number of human carcinomas...
  45. Ogasawara S, Kaneko M, Price J, Kato Y. Characterization of anti-podoplanin monoclonal antibodies: critical epitopes for neutralizing the interaction between podoplanin and CLEC-2. Hybridoma (Larchmt). 2008;27:259-67 pubmed publisher
    b>Podoplanin (Aggrus) is a mucin-type sialoglycoprotein that is known as a useful marker for lymphatic endothelium and tumor-initiating cells (TICs)...
  46. Martín Villar E, Megias D, Castel S, Yurrita M, Vilaró S, Quintanilla M. Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. J Cell Sci. 2006;119:4541-53 pubmed
    b>Podoplanin is a small membrane mucin expressed in tumors associated with malignant progression. It is enriched at cell-surface protrusions where it colocalizes with members of the ERM (ezrin, radixin, moesin) protein family...
  47. Chuang W, Yeh C, Wu Y, Chao Y, Liu Y, Tseng C, et al. Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma. Histol Histopathol. 2009;24:1021-7 pubmed publisher
    b>Podoplanin is a mucin-like glycoprotein expressed in the lymphatic endothelium...
  48. Tsuneki M, Yamazaki M, Maruyama S, Cheng J, Saku T. Podoplanin-mediated cell adhesion through extracellular matrix in oral squamous cell carcinoma. Lab Invest. 2013;93:921-32 pubmed publisher
    b>Podoplanin (PDPN), one of the representative mucin-like type-I transmembrane glycoproteins specific to lymphatic endothelial cells, is expressed in various cancers including squamous cell carcinoma (SCC)...
  49. Cueni L, Detmar M. Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions. Exp Cell Res. 2009;315:1715-23 pubmed publisher
    b>Podoplanin is a small, mucin-like membrane glycoprotein highly expressed by lymphatic but not by blood vascular endothelial cells...
  50. Miyata K, Takemoto A, Okumura S, Nishio M, Fujita N. Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation. Sci Rep. 2017;7:4059 pubmed publisher
    b>Podoplanin/Aggrus, known as a platelet aggregation-inducing factor, is frequently overexpressed in lung squamous cell carcinomas (LSCC) and glioblastomas among other tumours, and its expression has been reported to be correlated with poor ..
  51. DeCicco RePass M, Bhat N, Heimburg Molinaro J, BUNNELL S, Cummings R, Ward H. Molecular cloning, expression, and characterization of UDP N-acetyl-α-d-galactosamine: Polypeptide N-acetylgalactosaminyltransferase 4 from Cryptosporidium parvum. Mol Biochem Parasitol. 2018;221:56-65 pubmed publisher
    ..parvum gp40-derived peptide, with a preference for the former, suggesting it may play a role in modifying this glycoprotein in ..
  52. Zhang G, Li R, Zhao X, Meng S, Ye J, Zhao L. Validation of the American Joint Committee on Cancer eighth edition staging system in patients undergoing hepatectomy for hepatocellular carcinoma: a US population-based study. J Surg Res. 2018;222:55-68 pubmed publisher
    ..928 and 0.872, respectively). On the basis of the above results, we reclassified T1a, T1b, and T2 into several subgroups...
  53. Kimura K, Amano R, Ymazoe S, Ohira G, Nishio K, Hirakawa K, et al. The Clinical Indications for Limited Surgery of Intraductal Papillary Mucinous Neoplasms of the Pancreas. World J Surg. 2017;41:1358-1365 pubmed publisher
    ..Inv-IPMNs were divided into T1a, T1b, and T1c or over T1c (?T1c)...
  54. Suzuki Inoue K. CLEC-2, the novel platelet activation receptor and its internal ligand, podoplanin. Rinsho Ketsueki. 2009;50:389-98 pubmed
  55. del Rey M, Faré R, Izquierdo E, Usategui A, Rodríguez Fernández J, Suárez Fueyo A, et al. Clinicopathological correlations of podoplanin (gp38) expression in rheumatoid synovium and its potential contribution to fibroblast platelet crosstalk. PLoS ONE. 2014;9:e99607 pubmed publisher
    ..This study was undertaken to evaluate the clinical and functional significance of ectopic podoplanin (gp38) expression by RA SF...
  56. Malik R, Aldİnç E, Chan S, Deerochanawong C, Hwu C, Rosales R, et al. Perceptions of Painful Diabetic Peripheral Neuropathy in South-East Asia: Results from Patient and Physician Surveys. Adv Ther. 2017;34:1426-1437 pubmed publisher
    ..For a chronic and debilitating complication like pDPN, the physician-patient dialogue is central to maximizing patient outcomes. Strategies, including education of both groups, need to be developed to improve communication. Pfizer. ..
  57. Grzegrzolka J, Wojtyra P, Biala M, Piotrowska A, Gomulkiewicz A, Rys J, et al. Correlation Between Expression of Twist and Podoplanin in Ductal Breast Carcinoma. Anticancer Res. 2017;37:5485-5493 pubmed
    ..One of the specific markers of cancer-associated fibroblasts is podoplanin (PDPN) - a mucin-type membrane glycoprotein...