PNPLA2

Summary

Gene Symbol: PNPLA2
Description: patatin like phospholipase domain containing 2
Alias: 1110001C14Rik, ATGL, FP17548, PEDF-R, TTS-2.2, TTS2, iPLA2zeta, patatin-like phospholipase domain-containing protein 2, IPLA2-zeta, TTS2.2, adipose triglyceride lipase, calcium-independent phospholipase A2, desnutrin, mutant patatin-like phospholipase domain containing 2, pigment epithelium-derived factor, transport-secretion protein 2.2, triglyceride hydrolase
Species: human

Top Publications

  1. ncbi Pigment epithelium-derived factor in the monkey retinal pigment epithelium and interphotoreceptor matrix: apical secretion and distribution
    S Patricia Becerra
    Laboratory of Retinal Cell and Molecular Biology, NEI, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, MD 20892 0706, USA
    Exp Eye Res 78:223-34. 2004
  2. pmc Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine
    Christine Moessinger
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    J Biol Chem 286:21330-9. 2011
  3. pmc Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-kappaB
    Tomoaki Inoue
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 286:32045-53. 2011
  4. ncbi Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis
    Josep A Villena
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    J Biol Chem 279:47066-75. 2004
  5. ncbi Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:48968-75. 2004
  6. ncbi Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    Robert Zimmermann
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Science 306:1383-6. 2004
  7. pmc ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells
    Elena Smirnova
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    EMBO Rep 7:106-13. 2006
  8. ncbi The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes
    Veit Schoenborn
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular Clinical Pharmacology, Innsbruck Medical University, Schopfstrasse 41, A 6020 Innsbruck, Austria
    Diabetes 55:1270-5. 2006
  9. ncbi Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome
    Achim Lass
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    Cell Metab 3:309-19. 2006
  10. ncbi Characterization of the human patatin-like phospholipase family
    Paul A Wilson
    Bioinformatics Discovery and Analysis, GlaxoSmithKline Research and Development, Stevenage, England SG1 2NY, UK
    J Lipid Res 47:1940-9. 2006

Research Grants

  1. Jun Liu; Fiscal Year: 2014
  2. Zhanxiang Zhou; Fiscal Year: 2016
  3. The Role of Novel Angiogenic Signals in Post-Stroke Neurogenesis
    ANDREW JOHN BRUMM; Fiscal Year: 2013
  4. Dawn L Brasaemle; Fiscal Year: 2014
  5. Enrique Saez; Fiscal Year: 2014
  6. A Drosophila Model for Genetic Studies of Metabolism
    Carl S Thummel; Fiscal Year: 2010
  7. Erin E Kershaw; Fiscal Year: 2015
  8. Donald B Jump; Fiscal Year: 2015
  9. Hei Sook Sul; Fiscal Year: 2015
  10. CGI-58 Regulation of Triglyceride Metabolism and Inflammation
    JENNA BETTERS; Fiscal Year: 2010

Detail Information

Publications222 found, 100 shown here

  1. ncbi Pigment epithelium-derived factor in the monkey retinal pigment epithelium and interphotoreceptor matrix: apical secretion and distribution
    S Patricia Becerra
    Laboratory of Retinal Cell and Molecular Biology, NEI, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, MD 20892 0706, USA
    Exp Eye Res 78:223-34. 2004
    ..PEDF can be a useful marker for RPE polarization and differentiation. The polarization of RPE may be an important mechanism to control PEDF secretion and our results offer interesting possibilities on regulation of PEDF...
  2. pmc Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine
    Christine Moessinger
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    J Biol Chem 286:21330-9. 2011
    ..This suggests that LPCAT1 and -2 have, in addition to their known function in specialized cells, a ubiquitous role in LD-associated lipid metabolism...
  3. pmc Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-kappaB
    Tomoaki Inoue
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 286:32045-53. 2011
    We examined the effects of adipose triglyceride lipase (ATGL) on the initiation of atherosclerosis. ATGL was recently identified as a rate-limiting triglyceride (TG) lipase...
  4. ncbi Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis
    Josep A Villena
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    J Biol Chem 279:47066-75. 2004
    ..0-kb mRNA coding for a putative protein that we have designated as desnutrin. The novel gene is expressed predominantly in adipose tissue, and its expression is induced early during 3T3-L1 ..
  5. ncbi Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:48968-75. 2004
    ..motifs identified a novel subfamily of three putative iPLA2/lipase family members designated iPLA2epsilon, iPLA2zeta, and iPLA2eta (previously named adiponutrin, TTS-2...
  6. ncbi Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    Robert Zimmermann
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Science 306:1383-6. 2004
    ..Here, we report that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis...
  7. pmc ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells
    Elena Smirnova
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    EMBO Rep 7:106-13. 2006
    ..Recently, a novel triglyceride lipase (adipose triglyceride lipase (ATGL)) that catalyses the initial step in triglyceride hydrolysis in adipocyte LDs was identified...
  8. ncbi The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes
    Veit Schoenborn
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular Clinical Pharmacology, Innsbruck Medical University, Schopfstrasse 41, A 6020 Innsbruck, Austria
    Diabetes 55:1270-5. 2006
    b>Adipose triglyceride lipase (ATGL) was recently described to predominantly perform the initial step in triglyceride hydrolysis and therefore seems to play a pivotal role in the lipolytic catabolism of stored fat in adipose tissue...
  9. ncbi Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome
    Achim Lass
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    Cell Metab 3:309-19. 2006
    b>Adipose triglyceride lipase (ATGL) was recently identified as an important triacylglycerol (TG) hydrolase promoting the catabolism of stored fat in adipose and nonadipose tissues...
  10. ncbi Characterization of the human patatin-like phospholipase family
    Paul A Wilson
    Bioinformatics Discovery and Analysis, GlaxoSmithKline Research and Development, Stevenage, England SG1 2NY, UK
    J Lipid Res 47:1940-9. 2006
    ..Given the observed conservation of the patatin fold and lipase motif in all human PNPLAs, a single nomenclature to describe the PNPLA family is proposed...
  11. ncbi Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor
    Luigi Notari
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:38022-37. 2006
    ..Recently, PEDF-R (TTS-2.2/independent phospholipase A(2) (PLA(2))zeta and mouse desnutrin/ATGL) has been described in adipose cells as a member of the new calcium-independent PLA(2)/nutrin/patatin-like ..
  12. ncbi The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy
    Judith Fischer
    Centre National de Genotypage, 91057 Evry Cedex, France
    Nat Genet 39:28-30. 2007
    ..disease subgroup characterized by mild myopathy, absence of ichthyosis and mutations in both alleles of adipose triglyceride lipase (PNPLA2, also known as ATGL)...
  13. ncbi Analysis of lipolytic protein trafficking and interactions in adipocytes
    James G Granneman
    Department of Psychiatry and Behavioral Neurosciences, Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 282:5726-35. 2007
    ..to perilipin A (Plin)-containing droplets and increases the colocalization of adipose tissue triglyceride lipase (Atgl) with its coactivator, Abhd5...
  14. ncbi Novel duplication mutation in the patatin domain of adipose triglyceride lipase (PNPLA2) in neutral lipid storage disease with severe myopathy
    Masashi Akiyama
    Department of Dermatology, Hokkaido University Graduate School of Medicine, N15 W7, Sapporo 060 8638, Japan
    Muscle Nerve 36:856-9. 2007
    Recently, mutations in PNPLA2 encoding adipose triglyceride lipase (ATGL) were reported to underlie a neutral lipid storage disease (NLSD) subgroup characterized by mild myopathy and the absence of ichthyosis...
  15. doi The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Biol Chem 283:17211-20. 2008
    b>Adipose triglyceride lipase (ATGL) catalyzes the first step in the hydrolysis of triacylglycerol (TG) generating diacylglycerol and free fatty acids. The enzyme requires the activator protein CGI-58 (or ABHD5) for full enzymatic activity...
  16. doi The lack of the C-terminal domain of adipose triglyceride lipase causes neutral lipid storage disease through impaired interactions with lipid droplets
    Kunihisa Kobayashi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    J Clin Endocrinol Metab 93:2877-84. 2008
    ..The molecular mechanisms by which triglycerides in lipid droplets (LDs) are synthesized, stored, and degraded need to be elucidated...
  17. doi Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores
    Rudolf Zechner
    Institute of Molecular Biosciences, University of Graz, Austria
    J Lipid Res 50:3-21. 2009
    ..lipase (MGL), discovered more than 40 years ago, as well as the relatively recently identified adipose triglyceride lipase (ATGL)...
  18. doi Fate of fat: the role of adipose triglyceride lipase in lipolysis
    Robert Zimmermann
    Insitute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    Biochim Biophys Acta 1791:494-500. 2009
    ..PAT) family of lipid droplet binding proteins and the identification of a novel TG hydrolase named adipose triglyceride lipase (ATGL)...
  19. pmc Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
    Petra C Kienesberger
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Lipid Res 50:S63-8. 2009
    ..This review aims to summarize current knowledge of PNPLA proteins and to document their emerging importance in lipid and energy homeostasis...
  20. doi Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training
    Thomas J Alsted
    University of Copenhagen, The August Krogh Bldg 13, Universitetsparken, DK, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 296:E445-53. 2009
    ..Recently, adipose triglyceride lipase (ATGL) was identified as a TG-specific lipase in various rodent tissues...
  21. doi Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Am J Physiol Endocrinol Metab 297:E289-96. 2009
    ..Recently, two genes, adipose triglyceride lipase (ATGL/PNPLA2) and comparative gene identification-58 (CGI-58/ABHD5), have been shown to cause NLSD...
  22. pmc Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes
    Veronic Bezaire
    INSERM U858, Laboratoire de recherches sur les obésités, F 31432 Toulouse, France
    J Biol Chem 284:18282-91. 2009
    Lipolysis is the catabolic pathway by which triglycerides are hydrolyzed into fatty acids. Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) have the capacity to hydrolyze in vitro the first ester bond of ..
  23. pmc Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein
    Hong Wang
    Geriatric Research, Education, and Clinical Center, Baltimore Veterans Affairs Health Care Center, Division of Endocrinology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 286:15707-15. 2011
    ..We investigated mechanisms by which three perilipin proteins control lipolysis by adipocyte triglyceride lipase (ATGL), a key lipase in adipocytes and non-adipose cells...
  24. pmc Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans
    Pierre Marie Badin
    INSERM, U1048, Obesity Research Laboratory, Institute of Metabolicand Cardiovascular Diseases I2MC, Toulouse, France
    Diabetes 60:1734-42. 2011
    ..DAGs are by-products of lipolysis consecutive to TAG hydrolysis by adipose triglyceride lipase (ATGL) and are subsequently hydrolyzed by hormone-sensitive lipase (HSL)...
  25. doi Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue
    Thomas S Nielsen
    Medical Research Laboratories, Aarhus University Hospital, 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 96:E1293-7. 2011
    ..Fasting and exercise are characterized by increased lipolysis, but the underlying mechanisms are not fully understood...
  26. doi Adipose triglyceride lipase contributes to cancer-associated cachexia
    Suman K Das
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Science 333:233-8. 2011
    ..We show that the inhibition of lipolysis through genetic ablation of adipose triglyceride lipase (Atgl) or hormone-sensitive lipase (Hsl) ameliorates certain features of cancer-associated cachexia (..
  27. doi Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes
    Thomas S Nielsen
    Medical Research Laboratories, Aarhus University Hospital, 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 97:E1348-52. 2012
    ..Increased lipolysis and free fatty acid (FFA) levels contribute significantly to the pathogenesis of chronic and acute insulin resistance in type 2 diabetes, but the underlying mechanisms are uncertain...
  28. doi Phosphorylation of adipose triglyceride lipase Ser(404) is not related to 5'-AMPK activation during moderate-intensity exercise in humans
    Rachael R Mason
    Biology of Lipid Metabolism Laboratory, Department of Physiology, Monash University, Clayton, Victoria, Australia
    Am J Physiol Endocrinol Metab 303:E534-41. 2012
    ..The protein adipose triglyceride lipase (ATGL) is a key regulator of triacylglycerol lipolysis and whole body energy metabolism at rest and ..
  29. pmc Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A
    Harald M Nagy
    Institute of Molecular Biosciences, University of Graz, Austria
    Biochim Biophys Acta 1841:588-94. 2014
    b>Adipose triglyceride lipase (ATGL) is required for efficient mobilization of triglyceride (TG) stores in adipose tissue and non-adipose tissues. Therefore, ATGL strongly determines the availability of fatty acids for metabolic reactions...
  30. ncbi Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity
    A Mairal
    INSERM, U586, Obesity Research Unit, Toulouse, France
    Diabetologia 49:1629-36. 2006
    The recent identification of murine adipose triglyceride lipase (ATGL, now known as patatin-like phospholipase domain containing 2 [PNPLA2]), gene product of Pnpla2, has questioned the unique role of hormone sensitive lipase (HSL, now ..
  31. pmc Characterization of desnutrin functional domains: critical residues for triacylglycerol hydrolysis in cultured cells
    Robin E Duncan
    Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720, USA
    J Lipid Res 51:309-17. 2010
    Murine desnutrin/human ATGL is a triacylglycerol (TAG) hydrolase with a predicted catalytic dyad within an alpha-beta hydrolase fold in the N-terminal region...
  32. ncbi Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit
    Christopher T Johansen
    Robarts Research Institute, University of Western Ontario, London, Canada
    Int J Circumpolar Health 69:3-12. 2010
    To genotype common genetic variants found in the adipose triglyceride lipase (ATGL) gene and test them for association with cardiovascular disease risk factors in the Greenland Inuit.
  33. pmc Adipose triglyceride lipase expression in human adipose tissue and muscle. Role in insulin resistance and response to training and pioglitazone
    Aiwei Yao-Borengasser
    Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Metabolism 60:1012-20. 2011
    b>Adipose triglyceride lipase (ATGL) catalyzes the first step in adipocyte and muscle triglyceride hydrolysis, and comparative gene identification-58 (CGI-58) is an essential cofactor...
  34. ncbi [Effects of tumor necrosis factor-alpha induced insulin resistance on adipose triglyceride lipase in mice]
    Yu lan Cheng
    Key Laboratory of Laboratory Medical Diagnostics in Ministry of Education, Department of Clinical Biochemistry, Chongqing Medical University, Chongqing 400016, China
    Zhonghua Yi Xue Za Zhi 88:2417-21. 2008
    To investigate the effects of tumor necrosis factor (TNF)-alpha induced insulin resistance (IR) on glucose and lipid metabolism and adipose triglyceride lipase (ATGL).
  35. ncbi The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPARgamma
    Ji Young Kim
    Dept of Biochemistry and Cancer Biology, Medical University of Ohio, Toledo, OH 43614, USA
    Am J Physiol Endocrinol Metab 291:E115-27. 2006
    ..Recent studies have characterized a new adipose tissue triglyceride lipase, ATGL/PNPLA2/destnutrin/iPLA2zeta/TTS2.2 (ATGL)...
  36. pmc Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion
    Marie Line Peyot
    Molecular Nutrition Unit and Montreal Diabetes Research Center, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec H1W4A4, Canada
    J Biol Chem 284:16848-59. 2009
    ..Using real time-quantitative PCR, adipose triglyceride lipase (ATGL) was found to be the most abundant TG lipase in rat islets and INS832/13 cells...
  37. doi Breed difference and regulation of the porcine adipose triglyceride lipase and hormone sensitive lipase by TNFalpha
    T Shan
    Institute of Feed Science, Zhejiang University, Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou 310029, China
    Anim Genet 40:863-70. 2009
    b>Adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL) are major novel triglyceride lipases in animals...
  38. doi Tissue distribution of lipase genes related to triglyceride metabolism in laying hens (Gallus gallus)
    Kan Sato
    Animal Science, Department of Biological Production, Tokyo University of Agriculture and Technology, Fuchu shi, Tokyo, 183 8509, Japan
    Comp Biochem Physiol B Biochem Mol Biol 155:62-6. 2010
    ..carboxyl ester lipase (CEL), endothelial lipase (EL), Lipase H, hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), plays a critical role in lipid metabolism in mammals...
  39. doi Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK
    Mandeep P Gaidhu
    Muscle Health Research Centre, York Univ, 4700 Keele St, Toronto, ON, Canada M3J 1P3
    Am J Physiol Cell Physiol 298:C961-71. 2010
    ..Eight-weeks of HFD feeding increased adipose triglyceride lipase (ATGL) content and comparative gene identification-58 (CGI-58) expression, whereas hormone-sensitive ..
  40. ncbi [The mechanisms of stimulated lipolysis by high concentration of glucose in primary rat adipocytes]
    Ting Ting Zhang
    Department of Endocrinology, Peking University First Hospital, Beijing, China
    Beijing Da Xue Xue Bao 40:273-9. 2008
    ..To investigate the cellular mechanisms of adipocyte lipolytic response to a high concentration of glucose, which liberates free fatty acids (FFA) efflux from adipose cells to plasma...
  41. doi Regulation of adipose triglyceride lipase by fasting and refeeding in avian species
    J Serr
    Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA
    Poult Sci 88:2585-91. 2009
    ..b>Adipose triglyceride lipase (ATGL) is an adipose-specific enzyme that cleaves at the Sn-1 position of triglycerides, releasing ..
  42. pmc Effects of rosiglitazone and high fat diet on lipase/esterase expression in adipose tissue
    Wen Jun Shen
    Division of Endocrinology, Stanford University and VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Biochim Biophys Acta 1771:177-84. 2007
    ..We found that the relative mRNA levels of ATGL and HSL are the most abundant, being 2-3 fold greater than TGH or ADPN; whereas other intracellular neutral lipase/..
  43. doi Porcine adipose triglyceride lipase complementary deoxyribonucleic acid clone, expression pattern, and regulation by resveratrol
    T Shan
    Institute of Feed Science, Zhejiang University, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, No 164 Qiutao North Road, Hangzhou 310029, PR China
    J Anim Sci 86:1781-8. 2008
    b>Adipose triglyceride lipase (ATGL) was recently identified and described as a major novel triglyceride lipase in animals...
  44. doi Lipolysis and lipid mobilization in human adipose tissue
    Max Lafontan
    INSERM U, Institut de Medecine Moleculaire de Rangueil, IFR BMT, Toulouse, France
    Prog Lipid Res 48:275-97. 2009
    ..A novel lipase named adipose triglyceride lipase/desnutrin (ATGL) has been identified as playing an important role in the control of fat cell lipolysis...
  45. doi Cloning and functional characterization of the 5' regulatory region of ovine Hormone Sensitive Lipase (HSL) gene
    Antonis D Lampidonis
    Department of Animal Science, Laboratory of Animal Breeding and Husbandry, Agricultural University of Athens, Iera Odos 75, 118 55 Athens, Greece
    Gene 427:65-79. 2008
    ..stores and the only component being subjected to hormonal control in terms of the recently identified Adipose Triglyceride Lipase (ATGL)...
  46. pmc Reduction of endogenous angiogenesis inhibitors in Bruch's membrane of the submacular region in eyes with age-related macular degeneration
    Imran A Bhutto
    Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287 9115, USA
    Arch Ophthalmol 126:670-8. 2008
    ....
  47. pmc Effect of subconjuctival and intraocular bevacizumab injection on angiogenic gene expression levels in a mouse model of corneal neovascularization
    Olga Dratviman-Storobinsky
    The Krieger Eye Research Laboratory, Felsenstein Medical Research Center, Petah Tiqwa, Israel
    Mol Vis 15:2326-38. 2009
    ..In addition, the effectiveness of the treatment was compared to a rabbit model...
  48. pmc Increased angiogenic factors associated with peripheral avascular retina and intravitreous neovascularization: a model of retinopathy of prematurity
    Steven J Budd
    Department of Ophthalmology, School of Medicine, University of North Carolina, 130 Mason Farm Rd, Campus Box 7040, Chapel Hill, NC 27599 7040, USA
    Arch Ophthalmol 128:589-95. 2010
    ..To determine expression of vascular endothelial growth factor (VEGF), pigment epithelium-derived factor, and their respective receptors in retinas using a model of retinopathy of prematurity...
  49. ncbi Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment
    N Ogata
    Department of Ophthalmology, Kansai Medical University, Fumizono cho 10 15, Moriguchi, Osaka 570 8507, Japan
    Am J Ophthalmol 132:378-82. 2001
    ..To report the levels of pigment epithelium-derived factor in the vitreous of patients with diabetic retinopathy, rhegmatogenous retinal detachment, and idiopathic macular hole...
  50. doi Cloning and functional characterization of the ovine Hormone Sensitive Lipase (HSL) full-length cDNAs: an integrated approach
    Antonis D Lampidonis
    Department of Animal Science, Agricultural University of Athens, Iera Odos 75, 118 55 Athens, Greece
    Gene 416:30-43. 2008
    ..stores and the only enzyme being subjected to hormonal regulation [in terms of the recently identified Adipose Triglyceride Lipase (ATGL)], the ovine Hormone Sensitive Lipase (ovHSL) full-length cDNA clones were isolated, using a ..
  51. ncbi Ultrasound-mediated microbubble delivery of pigment epithelium-derived factor gene into retina inhibits choroidal neovascularization
    Xi Yuan Zhou
    Department of Ophthalmology, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, China
    Chin Med J (Engl) 122:2711-7. 2009
    ....
  52. doi Role of soluble vascular endothelial growth factor receptor-1 in the vitreous in proliferative diabetic retinopathy
    Nozomu Matsunaga
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    Ophthalmology 115:1916-22. 2008
    ..Furthermore, to investigate the relationships among sVEGFR-1, vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF)...
  53. ncbi In vitro studies of pigment epithelium-derived factor in human Schwann cells after treatment with axolemma-enriched fraction
    Terakeith Lertsburapa
    Department of Cell Biology, Neurobiology and Anatomy, Loyola University of Chicago, Maywood, Illinois, USA
    J Neurosci Res 75:624-31. 2004
    ..These results suggest that MPNST SC lose the ability to downregulate PEDF upon axonal contact, which is characteristic of HSC. The elevated PEDF levels expressed by MPNST cell lines may serve to promote their proliferation and survival...
  54. pmc Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis
    Brendan N Reid
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 283:13087-99. 2008
    ..In this study, we have demonstrated that hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), two enzymes critical for lipolysis in adipose tissues, also contribute to lipolysis in the ..
  55. pmc VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: relevance to clinical ROP
    Janet R McColm
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7041, USA
    Mol Vis 10:512-20. 2004
    ..We also determined whether pigment epithelium-derived factor (PEDF) was dysregulated by oxygen fluctuations perhaps contributing to a delay in normal retinal vascular development...
  56. ncbi Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 281:40236-41. 2006
    ..In this study, we demonstrate that adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are the major enzymes contributing to TG breakdown in in ..
  57. doi Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity
    Johan W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Physiol Behav 94:219-30. 2008
    ..The recently discovered adipose triglyceride lipase (ATGL) seems not to be involved in the catecholamine resistance of lipolysis observed in abdominal ..
  58. doi Omental adipose tissue overexpression of fatty acid transporter CD36 and decreased expression of hormone-sensitive lipase in insulin-resistant women with polycystic ovary syndrome
    Kok Min Seow
    Department of Obstetrics and Gynecology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Hum Reprod 24:1982-8. 2009
    ..We investigated the role of fatty acid transporter CD36, hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) in regulation of lipolysis in insulin-resistant women with PCOS.
  59. ncbi Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor
    J Ortego
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Invest Ophthalmol Vis Sci 37:2759-67. 1996
    ..To study the expression of the neurotrophic pigment epithelium-derived factor (PEDF), a protein with neurotrophic and neuronal-survival activities, by the human ocular ciliary epithelium...
  60. pmc Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes
    Hideaki Miyoshi
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Cell Biochem 105:1430-6. 2008
    ..b>Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are the major rate-determining enzymes for lipolysis in ..
  61. pmc Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores
    Achim Lass
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    Prog Lipid Res 50:14-27. 2011
    ..These include an essential TAG hydrolase named adipose triglyceride lipase (ATGL) [annotated as patatin-like phospholipase domain-containing protein A2], the ATGL activator ..
  62. ncbi Mapping the type I collagen-binding site on pigment epithelium-derived factor. Implications for its antiangiogenic activity
    Christina Meyer
    Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, Bethesda, Maryland 20892 2740, USA
    J Biol Chem 277:45400-7. 2002
    ..The collagen-binding property of PEDF may play a role in surface localization and modulation of its antiangiogenic effects in the eye and bone...
  63. doi Changes of aqueous vascular endothelial growth factor and pigment epithelium-derived factor following intravitreal bevacizumab for macular oedema secondary to branch retinal vein occlusion
    Sung P Park
    Department of Ophthalmology, Hallym University Medical School, Seoul, Korea
    Clin Experiment Ophthalmol 37:490-5. 2009
    ....
  64. pmc Pigment epithelium-derived factor protects retinal ganglion cells
    Iok Hou Pang
    Alcon Research, Ltd, 6201 South Freeway, R3 24, Fort Worth, TX 76134, USA
    BMC Neurosci 8:11. 2007
    ..We tested the effects of PEDF on the survival of cultured adult rat RGCs in the presence of glaucoma-like insults, including cytotoxicity induced by glutamate or withdrawal of trophic factors...
  65. doi Protective role of pigment epithelium-derived factor (PEDF) in early phase of experimental diabetic retinopathy
    Yumiko Yoshida
    Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan
    Diabetes Metab Res Rev 25:678-86. 2009
    ..However, a role for PEDF in early diabetic retinopathy remains to be elucidated. We investigated here whether and how PEDF could prevent the development of diabetic retinopathy...
  66. pmc Long-term ritonavir exposure increases fatty acid and glycerol recycling in 3T3-L1 adipocytes as compensatory mechanisms for increased triacylglycerol hydrolysis
    Diane C Adler-Wailes
    Head, Unit on Growth and Obesity, National Institutes of Health, Hatfield Clinical Research Center, Bethesda, Maryland 20892 1103, USA
    Endocrinology 151:2097-105. 2010
    ..To identify a mediator of FA efflux, we measured adipocyte triacylglycerol lipase (ATGL) transcript and protein...
  67. ncbi Pigment epithelium-derived factor, a human testis epididymis secretory product, promotes human prostate stromal cell growth in culture
    John T Grayhack
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 171:434-8. 2004
    ..We identified and characterized unrecognized testicular secretory proteins that impact human prostate growth...
  68. pmc Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization
    Steen V Petersen
    Department of Molecular Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
    Biochem J 374:199-206. 2003
    ..The pyroglutamate residue may regulate the activity of PEDF analogously to the manner in which it regulates thyrotropin-releasing hormone...
  69. ncbi In vivo gene transfer of pigment epithelium-derived factor inhibits tumor growth in syngeneic murine models of thoracic malignancies
    Ali Mahtabifard
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Thorac Cardiovasc Surg 126:28-38. 2003
    ..We hypothesized that in vivo gene transfer of pigment epithelium-derived factor may inhibit tumor angiogenesis and growth in syngeneic models of thoracic malignancies...
  70. ncbi Pigment epithelium-derived factor supports normal Müller cell development and glutamine synthetase expression after removal of the retinal pigment epithelium
    M M Jablonski
    Retinal Degeneration Research Center, Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Glia 35:14-25. 2001
    ....
  71. ncbi Isoproterenol, TNFalpha, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes
    Susan Kralisch
    University of Leipzig, Department of Internal Medicine III, Leipzig, Germany
    Mol Cell Endocrinol 240:43-9. 2005
    Recently, adipose triglyceride lipase (ATGL, also called desnutrin and calcium-independent phospholipase A2 [iPLA(2)] zeta) was isolated as a novel adipose-expressed triglyceride lipase which is downregulated in obesity and may ..
  72. ncbi Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy
    Sarah X Zhang
    Department of Medicine, Department of Cell Biology, University of Oklahoma Health Sciences Center, 941 Stanton L Young Blvd, Oklahoma City, OK, USA
    J Mol Endocrinol 37:1-12. 2006
    ..The decrease in PEDF levels in the retina is at least partially responsible for the increase in VEGF expression and subsequent vascular leakage and neovascularization in diabetes...
  73. ncbi Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor alpha deficiency
    C G Walker
    Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, London, UK
    Int J Obes (Lond) 31:1165-71. 2007
    ..the impact of peroxisome proliferator-activated receptor alpha deficiency on gene expression of adipose triglyceride lipase and the glycerol transporter aquaglyceroporin 7 in white adipose tissue in the fed and fasted states in ..
  74. pmc Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy
    Masato Matsuoka
    Department of Ophthalmology, Kansai Medical University, Osaka, Japan
    Mol Vis 13:1058-65. 2007
    ....
  75. ncbi [Change and significance of serum pigment epithelium-derived factor in type 2 diabetic nephropathy]
    Hai Bing Chen
    Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Department of Endocrinology and Metabolism of Shanghai Sixth People s Hospita1 Affiliated to Shanghai Jiaotong University, Shanghai 200233, China
    Zhonghua Yi Xue Za Zhi 87:1230-3. 2007
    ..To investigate the change of pigment epithelium-derived factor (PEDF) in type 2 diabetic nephropathy, and to explore the significance of PEDF in the development of diabetic nephropathy...
  76. doi Pigment epithelium-derived factor inhibits vascular endothelial growth factor-and interleukin-1beta-induced vascular permeability and angiogenesis in retinal endothelial cells
    Sardarpasha Sheikpranbabu
    Department of Biotechnology, Division of Molecular and Cellular Biology, Kalasalingam University Kalasalingam Academy of Research and Education, Anand Nagar, Krishnankoil 626190, Tamilnadu, India
    Vascul Pharmacol 52:84-94. 2010
    ..These results demonstrate that PEDF may inhibit the VEGF-and IL-1beta-induced permeability and angiogenesis via Src-dependent pathway...
  77. ncbi Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease
    J Spranger
    University Hospital Benjamin Franklin, Free University of Berlin, Germany
    Diabetes 50:2641-5. 2001
    ..Our findings suggest that substitution of angiogenesis inhibitors may be an effective approach in the treatment of PDR...
  78. ncbi Pigment epithelium-derived factor in ulcerative colitis: possible relationship with disease activity
    Alicja Wiercinska-Drapalo
    Department of Infectious Diseases, Medical University of Bialystok, Zurawia 14, 15 540 Bialystok, Poland
    Regul Pept 140:1-4. 2007
    ....
  79. ncbi Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy
    Hiroyuki Iizuka
    Division of RI Laboratory, Biomedical Research Center, Saitama Medical University, Saitama, Japan
    Biochem Biophys Res Commun 361:421-6. 2007
    ..These results demonstrate that the PEDF gene, in cooperation with the VEGF gene, may contribute to the development of DR...
  80. ncbi Administration of pigment epithelium-derived factor (PEDF) inhibits cold injury-induced brain edema in mice
    Yuko Jinnouchi
    Department of Medicine, Division of Cardio Vascular Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Brain Res 1167:92-100. 2007
    ..Our present study suggests that PEDF may be a novel therapeutic agent for the treatment of brain edema...
  81. doi Protein expression of pigment-epithelium-derived factor in rat cochlea
    Otto Gleich
    Department of Otorhinolaryngology, University of Regensburg, Regensburg, Germany
    Cell Tissue Res 332:565-71. 2008
    ..Our data constitute the first report on the morphological protein distribution of this multifunctional molecule in the rat cochlea and suggest its role in important functions of the internal ear...
  82. ncbi [The role of matrix metalloproteinases in the pathogenesis of diabetes mellitus and progression of diabetes retinopathy]
    Julia Naduk-Kik
    Zakład Enzymologii Medycznej, Katedra Biochemii Medycznej, Uniwersytet Medyczny w Łodzi
    Postepy Hig Med Dosw (Online) 62:442-50. 2008
    ....
  83. doi Cytosolic phospholipase A2-{alpha} is an early apoptotic activator in PEDF-induced endothelial cell apoptosis
    Tsung Chuan Ho
    Dept of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
    Am J Physiol Cell Physiol 296:C273-84. 2009
    ....
  84. pmc Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity
    Maryam Ahmadian
    Department of Nutritional Science and Toxicology, University of California, Berkeley, California, USA
    Diabetes 58:855-66. 2009
    To investigate the role of desnutrin in adipose tissue triacylglycerol (TAG) and fatty acid metabolism.
  85. ncbi Branched-chain amino acids and pigment epithelium-derived factor: novel therapeutic agents for hepatitis c virus-associated insulin resistance
    T Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Curr Med Chem 16:4843-57. 2009
    ..We also discuss here which chemical structures could contribute to insulin-sensitization in patients with HCV infection...
  86. doi Epidermal triglyceride levels are correlated with severity of ichthyosis in Dorfman-Chanarin syndrome
    Mayumi Ujihara
    Department of Dermatology, Kochi Medical School, Kochi University, Oko cho, Nankoku, Japan
    J Dermatol Sci 57:102-7. 2010
    ..DCS patients often have mutations in CGI-58, which is an activator of adipose triglyceride lipase (ATGL), leading to accumulation of triglycerides (TG).
  87. doi PEDF promotes retinal neurosphere formation and expansion in vitro
    Anna De Marzo
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Adv Exp Med Biol 664:621-30. 2010
    ..b>Pigment Epithelium Derived Factor (PEDF), a member of the serpin gene family, is synthesized and secreted by retinal pigment ..
  88. doi Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in macular edema with central retinal vein occlusion
    Hidetaka Noma
    Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women s Medical University, Yachiyo, Chiba, Japan
    Curr Eye Res 36:256-63. 2011
    ..To investigate whether pigment epithelium-derived factor (PEDF) or vascular endothelial growth factor (VEGF) influences macular edema in patients with central retinal vein occlusion (CRVO)...
  89. ncbi [Role of estrogen-related receptor alpha in adipocyes lipolysis]
    Dapeng Ju
    Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest Sci Tech University of Agriculture and Forestry, Yangling 712100, China
    Sheng Wu Gong Cheng Xue Bao 27:18-25. 2011
    ..of ERRalpha on lipolysis; Further, we analyzed the expression of PPARgamma, perilipin A, p-perilipin A, HSL and ATGL with Western blotting...
  90. ncbi Effect of Peucedanum japonicum Thunb on the expression of obesity-related genes in mice on a high-fat diet
    Natthanan Nukitrangsan
    United Graduate School of Agricultural Sciences, Kagoshima University, Japan
    J Oleo Sci 60:527-36. 2011
    ..PJT increased the expression of PPARγ, FXRα, DGAT1, and ATGL genes, suggesting an enhancement of adipocyte differentiation and normalization of functionality of adipose tissue.
  91. doi 3,5-Diiodo-L-thyronine modulates the expression of genes of lipid metabolism in a rat model of fatty liver
    Elena Grasselli
    DIPTERIS, Universita di Genova, Genova, Italy
    J Endocrinol 212:149-58. 2012
    ..Moreover, the expression of the adipose triglyceride lipase involved in lipid mobilisation, of the main PAT proteins acting in lipid droplet (LD) turnover, and of ..
  92. pmc CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action
    Caleb C Lord
    Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 61:355-63. 2012
    ..CGI-58 recently has been ascribed two distinct biochemical activities, including coactivation of adipose triglyceride lipase and acylation of lysophosphatidic acid (LPA)...
  93. doi Serum levels of pigment epithelium-derived factor (PEDF) are independently associated with procollagen III N-terminal peptide levels in patients with nonalcoholic fatty liver disease
    Hideyuki Hyogo
    Department of Medicine and Molecular Sciences, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Clin Biochem 45:1554-7. 2012
    ..However, the pathophysiological role of PEDF in NAFLD remains largely unknown. We studied here the relationship between serum PEDF levels and various clinical markers of NAFLD in humans...
  94. doi Porcine G₀/G₁ switch gene 2 (G0S2) expression is regulated during adipogenesis and short-term in-vivo nutritional interventions
    Jinsoo Ahn
    Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA
    Lipids 48:209-18. 2013
    b>Adipose triglyceride lipase (ATGL), catalyzing the initial step of hydrolysis of triacylglycerol (TAG) in adipocytes, has been known to be inhibited by G0/G1 switch gene 2 (G0S2)...
  95. pmc Human adipose-derived mesenchymal stromal cell pigment epithelium-derived factor cytotherapy modifies genetic and epigenetic profiles of prostate cancer cells
    Olga Zolochevska
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA
    Cytotherapy 16:346-56. 2014
    ....
  96. pmc Enhanced efficacy of combination therapy with adeno‑associated virus-delivered pigment epithelium-derived factor and cisplatin in a mouse model of Lewis lung carcinoma
    Sha Sha He
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P R China
    Mol Med Rep 9:2069-76. 2014
    ..These findings suggest that combination of AAV-hPEDF and cisplatin has potential as a novel therapeutic strategy for lung cancer. ..
  97. pmc Identification of a novel phosphorylation site in adipose triglyceride lipase as a regulator of lipid droplet localization
    Xitao Xie
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, Arizona HEALth Program, Mayo Clinic, Scottsdale, Arizona
    Am J Physiol Endocrinol Metab 306:E1449-59. 2014
    b>Adipose triglyceride lipase (ATGL), the rate-limiting enzyme for triacylglycerol (TG) hydrolysis, has long been known to be a phosphoprotein...
  98. pmc Cellular localization and associations of the major lipolytic proteins in human skeletal muscle at rest and during exercise
    Rachael R Mason
    Biology of Lipid Metabolism Laboratory, Department of Physiology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 9:e103062. 2014
    ..b>Adipose triglyceride lipase (ATGL) is a key regulator of skeletal muscle lipolysis and perilipin (PLIN) 5 is postulated to be an ..
  99. doi PEDF counteracts DL-α-aminoadipate toxicity and rescues gliotoxic damages in RPE-free chicken retinal explants
    Gopenath Thangaraj
    Technische Universitat Darmstadt, Entwicklungsbiologie und Neurogenetik, Schnittspahnstrasse 13, D 64287 Darmstadt, Germany
    Exp Eye Res 134:111-22. 2015
    ..These findings suggest that supplementation with PEDF can protect the retina against gliotoxic attacks. Further studies should establish whether PEDF similarly protects a gliotoxic human retina. ..
  100. pmc Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice
    Gabriele Schoiswohl
    Division of Endocrinology and Metabolism G S, M S R, R C W, B A S, M K B, M T S, L C, C F Y, R M O, E E K, Department of Medicine, and Department of Cell Biology D B S, University of Pittsburgh, Pittsburgh, Pennsylvania 15261 Department of Obstetrics, Gynecology, and Reproductive Sciences M N M, Magee Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 and Department of Biochemistry and Molecular Biology T P, Dalhousie Medicine New Brunswick, Dalhousie University, St John, Canada NB E2L 4L5
    Endocrinology 156:3610-24. 2015
    ..To test this hypothesis in vivo, we generated mice with adipocyte-specific deletion of adipose triglyceride lipase (ATGL), the rate-limiting enzyme catalyzing triacylglycerol hydrolysis...
  101. pmc Antiangiogenic and Neurogenic Activities of Sleeping Beauty-Mediated PEDF-Transfected RPE Cells In Vitro and In Vivo
    Sandra Johnen
    Department of Ophthalmology, University Hospital RWTH Aachen, Pauwelsstrase 30, 52074 Aachen, Germany
    Biomed Res Int 2015:863845. 2015
    ..We showed that transplantation of pigment epithelial cells overexpressing PEDF can restore a permissive subretinal environment for RPE and photoreceptor maintenance, while inhibiting choroidal blood vessel growth. ..

Research Grants66

  1. Jun Liu; Fiscal Year: 2014
    ..With the discovery of adipose triglyceride lipase (ATGL) as the rate-limiting enzyme in lipolysis, a clearer understanding of the molecular processes ..
  2. Zhanxiang Zhou; Fiscal Year: 2016
    ..On the other hand, chronic alcohol exposure activated both hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) pathways in the adipose tissue, indicating an upregulation of lipolysis...
  3. The Role of Novel Angiogenic Signals in Post-Stroke Neurogenesis
    ANDREW JOHN BRUMM; Fiscal Year: 2013
    ..As there are currently no treatments to promote post-stroke functional recovery, such signaling systems may be valuable targets for neural repair in human stroke. ..
  4. Dawn L Brasaemle; Fiscal Year: 2014
    ..binds CGI- 58, a Coenzyme A-dependent lysophosphatidic acid acyltransferase and co-activator of adipose triglyceride lipase (ATGL)...
  5. Enrique Saez; Fiscal Year: 2014
    ..Genetic ablation of adipose triglyceride lipase (ATGL) and to a lesser extent hormone sensitive lipase (HSL) can protect from cancer-associated ..
  6. A Drosophila Model for Genetic Studies of Metabolism
    Carl S Thummel; Fiscal Year: 2010
    ..can be rescued by introducing second-site mutations in genes that increase TAG levels, such as the adipose triglyceride lipase gene or the adipokinetic hormone receptor gene (which acts like glucagon to drive lipolysis)...
  7. Erin E Kershaw; Fiscal Year: 2015
    ..b>Adipose triglyceride lipase (ATGL) has recently been identified as the rate-limiting enzyme mediating TG hydrolysis, and is ..
  8. Donald B Jump; Fiscal Year: 2015
    ..Moreover, elevated Elovl5 activity induced adipocyte triglyceride lipase (ATGL), comparative gene identification-58 (CGI58, ATGL co-activator) and short &long chain acylcarnitines in livers ..
  9. Hei Sook Sul; Fiscal Year: 2015
    ..Here, we present preliminary data that show a previously unknown role for desnutrin, the major adipose TAG hydrolase in BAT phenotype and function...
  10. CGI-58 Regulation of Triglyceride Metabolism and Inflammation
    JENNA BETTERS; Fiscal Year: 2010
    ..CGI-58 appears to be a coactivator of adipose triglyceride lipase (ATGL)...
  11. James A Olzmann; Fiscal Year: 2015
    ..ubiquitination pathway that involves UBXD8-mediated recruitment of p97/VCP and regulation LD turnover catalyzed by ATGL, the rate-limiting enzyme in lipolysis...
  12. Defining the role of ubiquitination in the regulation of lipid droplet function
    James A Olzmann; Fiscal Year: 2013
    ..ubiquitination pathway that involves UBXD8-mediated recruitment of p97/VCP and regulation LD turnover catalyzed by ATGL, the rate-limiting enzyme in lipolysis...
  13. Anti-angiogenic Barriers to Tumor Development
    Susan E Crawford; Fiscal Year: 2010
    ..This proposed study has the potential to identify a novel signaling pathway in the pathogenesis of liver disease and it may validate PEDF gene therapy as a potent new agent to combat liver cancer. ..
  14. Regulation of lipolysis by mTORC1
    Konstantin V Kandror; Fiscal Year: 2012
    ..We have recently found that activation of mTORC1 inhibits expression of the rate-limiting lipolytic enzyme, ATGL, suppresses basal and cAMP-stimulated lipolysis, and causes marked accumulation of triglycerides in fat and muscle ..
  15. Exercise Effects on Serum Biomarkers of Angiogenesis
    CATHERINE ROSE DUGGAN; Fiscal Year: 2012
    ..The proposed study represents a unique opportunity to expand knowledge about the effects of physical activity on angiogenesis-related biomarkers, in a cost-effective and comprehensive manner by using an existing resource. ..
  16. Control of Eye Melanoma Metastsis
    Hans E Grossniklaus; Fiscal Year: 2010
    ..maintenance of dormancy by manipulating the intrinsic vascular endothelial growth factor (VEGF) to pigment epithelium derived factor (PEDF) ratio...
  17. Douglas G Mashek; Fiscal Year: 2015
    ..how the dynamic hepatic LD and nuclear lipidomes change in response to metabolic stimuli such as high fat feeding, ATGL-catalyzed lipolysis and B-adrenergic signaling...
  18. Zsolt Ablonczy; Fiscal Year: 2014
    ....
  19. Therapeutic Potential of A Novel Angiogenic Inhibitor
    James Ryan; Fiscal Year: 2003
    ..This study will use oxygen-induced retinopathy and streptozotocin (STZ)- induced diabetic rats as models. The effect of KBP injection on vascular permeability will be evaluated by the Evans Blue leakage method. ..
  20. Control of Angiogenesis in neonatal Hyperoxic Lung Injury
    Heber C Nielsen; Fiscal Year: 2012
    ..Our primary candidates are Pigment Epithelium Derived Factor (PEDF), and its upstream regulator Kringle 5 (K5)...
  21. Chuhan Chung; Fiscal Year: 2014
    ..We will selectively target v-ATPase subunits using molecular methods to determine whether this will inhibit pancreatic stellate cell and pancreatic cell growth in vivo. ..
  22. Haydee E P Bazan; Fiscal Year: 2016
    ..Our innovative approach will define potential agents for neurotrophic keratitis and dry eye after refractive surgery and HSV-1 infection. ..
  23. Nicolas G Bazan; Fiscal Year: 2016
    ..Moreover, A2E-mediated RPE cell apoptosis is inhibited by NPD1. We identified pigment epithelium derived factor (PEDF, a potent antiangiogenic growth factor) and other neurotrophins as NPD1-synthesis agonists, ..
  24. The Role of SPARC in Neuroblastoma Angiogenesis
    Susan Cohn; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  25. Richard W Gross; Fiscal Year: 2016
    ..have identified three major phospholipases and lipases in myocardium iPLA2? (PNPLA9), iPLA2? (PNPLA8), and iPLA2? (PNPLA2;ATGL) that likely serve as principal mediators of myocardial hemodynamic dysfunction, electrophysiologic ..
  26. Luisa A DiPietro; Fiscal Year: 2015
    ..The impact of these studies lies in their application to situations of disregulated angiogenesis (both too much and not enough), including non-healing wounds, malignancies, inflammatory diseases, scar formation, and tissue fibrosis. ..
  27. The Role of Neuroprotectin D1 in Choroidal Neovascularization
    KRISTOPHER GRAYE SHEETS; Fiscal Year: 2012
    ..The outcomes from this study could provide the basis of highly effective low-cost therapies for age-related macular degeneration. ..
  28. Kyu Sang Joeng; Fiscal Year: 2014
    ..This research will not only elucidate a novel regulatory mechanism for bone mineralization, but also establish the pathogenic mechanism of OI type VI, thus providing potential therapeutic strategies for patients with OI type VI. ..
  29. MATEUSZ S WIETECHA; Fiscal Year: 2014
    ..abstract_text> ..
  30. Thomas Nelius; Fiscal Year: 2014
    ..We also anticipate that this project will lead to the development of improved therapeutic approaches for prostate cancer. ..
  31. SEX PHEROMONE INDUCED PLASMID TRANSFER
    DON CLEWELL; Fiscal Year: 2002
    ..by a negative regulator encoded by traA that influences transcriptional readthrough of the termination site TTS1/TTS2. The bulk of the proposed study is designed to test this model and further characterize related processes...
  32. Novel adipocyte-specific enzymes in triacylglycerol metabolism
    Hei Sook Sul; Fiscal Year: 2009
    ..expression patterns and the presence of structural motifs for lipid metabolism, and we have named them desnutrin and adipocyte phospholipid acyltransferase (APAT)...
  33. Treatment of Ocular Neovascularization by Inhibitors
    Peter Gehlbach; Fiscal Year: 2005
    ..It will also provide me with clinical training to eventually translate the knowledge into new treatments for patients. ..
  34. Novel regulation of the anti-angiogenic activity of PEDF by pro-angiogenic MMPs
    CHRISTOPHER REITER; Fiscal Year: 2009
    ..Our research will advance the basic knowledge of the mechanism of pathological ocular angiogenesis, and will likely lead to advances in treatment of such diseases. ..
  35. Alternate Delivery of Potent Antiangiogenic Agent-AdPEDF
    Lisa Wei; Fiscal Year: 2004
    ..11 in preparation for clinical testing. Periocular delivery could provide a feasible and safer method of delivery of agents to the eye for wet AMD and other ocular diseases than intraocular methods. ..
  36. Alternate Adenovector in Eye Gives Longer Expression
    Lisa Wei; Fiscal Year: 2007
    ..If successful, the phase II SBIR application will be directed toward completing the rigorous efficacy and safety testing necessary for further clinical development. [unreadable] [unreadable] [unreadable]..
  37. PEDF Expression and Regulation in Lung Fibrosis
    Gregory Cosgrove; Fiscal Year: 2009
    ..Our proposed investigations will not only serve to define the regulation of an important angiostatic mediator, but also provide a better understanding as those mechanisms underlying the fibrotic response within the lung. ..
  38. Protein Production of PEDF-Potent Antiangiogenic Agent
    Lisa Wei; Fiscal Year: 2003
    ..Furthermore, the methods and procedures generated in the Phase I SBIR grant may lead to future viable manufacturing processes and assays that could lead to clinical grade material. ..
  39. ATGL: Major regulator of hepatic steatosis and energy metabolism
    Douglas G Mashek; Fiscal Year: 2010
    ..The objective of this application is to define the role of adipose triacylglycerol lipase (ATGL) in hepatic energy metabolism and in mediating diet-specific effects on steatosis and insulin resistance...
  40. PEDF, VEGF and Leptin in Serum, EDTA-Plasma, and Platelet Poor Plasma
    Susan Gapstur; Fiscal Year: 2009
    ..Our long-term goal is to study whether the associations of obesity with cancer risk and prognosis are mediated by leptin, PEDF, and/or VEGF. ..
  41. Development of PEDF Protein: An Antiangiogenic Agent
    Lisa Wei; Fiscal Year: 2005
    ..The results of these studies will be used to decide whether clinical testing of PEDF protein is warranted and if so, provide critical components of the data package necessary for an IND submission. ..
  42. Evaluation of High-Capacity Adenovectors in the Eye
    Joseph Bruder; Fiscal Year: 2006
    ..The long-term goal of this proposal is the clinical testing and commercialization of PEDF expressing HC vector for the treatment of AMD and other ocular neovascular diseases. [unreadable] [unreadable]..
  43. Analysis of Therapeutic Adipose Tissue Remodeling
    JAMES GRANNEMAN; Fiscal Year: 2004
    ..2) To examine adipose tissue cellular dynamics during therapeutic remodeling induced by agonist activation of beta3-adrenergic receptors and PPAR-gamma. ..
  44. BETA 1 AND BETA 3 ADRENORECEPTORS
    JAMES GRANNEMAN; Fiscal Year: 2001
    ..Aim 2. To further characterize the differential signaling properties of beta1- beta3-AR and to examine the cellular and molecular basis. Specific Aim 3. To examine the molecular pharmacology of beta3-AR-selective agonists. ..
  45. Lipid Droplets: Metabolic Consequences of Stored Neutral Lipids
    Dawn Brasaemle; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  46. Contribution of ATGL in skeletal muscle to lipid metabolism and insulin action
    ERIN KERSHAW; Fiscal Year: 2008
    ..Fat deposition in skeletal muscle is associated with insulin resistance with can lead to diabetes. Adipose triglyceride lipase (ATGL) has recently been identified as a new enzyme that breaks down fat, but its role in skeletal ..
  47. Thrombospondin-1 in prostate development and neoplasia
    Susan Crawford; Fiscal Year: 2004
    ..Results from these experiments should establish the function of TSP-1 in prostatic growth regulation and determine how TSP-1 may be useful as a prognostic indicator or as a treatment for prostatic diseases. ..
  48. Symposium on Retinal/ Choroidal Angiogenesis
    John Penn; Fiscal Year: 2004
    ..J. Donald M. Gass, M.D. has agreed to write an introduction. In this application we request funds to support travel and registration costs of 20 young investigators and 2 keynote speakers. ..
  49. Inhibition of CNV using a transgenic PEDF model
    Elia Duh; Fiscal Year: 2004
    ..In addition, our studies will provide a new experimental approach for the study of candidate inhibitors of CNV, providing important data regarding efficacy, therapeutic dose, frequency of administration, and toxicity. ..
  50. Pancreatic Development in Modeling Pancreatic Disease
    Paul Grippo; Fiscal Year: 2003
    ..Targeting pancreatic progenitor cells with various genetic alterations will provide valuable information for the developmental biologist and clinical pathologist alike. ..
  51. Pathogenesis of a Novel Limb-Girdle Muscular Dystrophy
    Michio Hirano; Fiscal Year: 2003
    ..For the patients, achieving the proposed goals will allow more accurate prenatal diagnosis, genetic counseling, and perhaps contribute to more rational therapies in the future. ..
  52. PECAM-1 AND REGULATION OF ANGIOGENESIS
    Nader Sheibani; Fiscal Year: 2003
    ..It is suggested that a therapeutic benefit can be derived by exploiting these signaling pathways to control the hypervascularization characteristic of arthritis. ..
  53. THE NHLBI BAY AREA FUNCTIONAL GENOMICS COMSORTIUM
    Stephen Young; Fiscal Year: 2003
    ..The Consortium's resources will be distributed freely to any interested investigator and should provide a catalyst for many different NHLBI-funded research programs. ..
  54. METABOLISM OF SPONTANEOUSLY DAMAGED PROTEINS IN AGING
    Stephen Young; Fiscal Year: 2002
    ..Finally, we propose to ask whether the expression of the repair methyltransferase in the extracellular compartment would limit the accumulation of spontaneous damage to extracellular proteins. ..
  55. THE UCLA CLINICAL NUTRITION RESEARCH UNIT
    David Heber; Fiscal Year: 2006
    ..The UCLA CNRU is serving as a regional and national resource at the cutting edge of nutrition and cancer prevention research...
  56. Endothelial Transmigration Across the RPE Barrier
    Mary Elizabeth Hartnett; Fiscal Year: 2005
    ..Increased knowledge of the mechanisms that cause this destructive phenomenon may lead to future means to prevent CNV in the neurosensory retina, and thus, reduce vision loss in AMD. ..
  57. Thrombospondin-1 and retininal vascular homeostasis
    Nader Sheibani; Fiscal Year: 2005
    ..This knowledge will provide the rationale for development of new therapeutic approaches for the prevention and/or treatment of ocular diseases with a neovascular component. ..
  58. Coordinate Regulation Of Nuclear DGK-theta and PLD
    DANIEL RABEN; Fiscal Year: 2009
    ..We believe that an understanding of nuclear lipid signaling is key to our ability to intervene in events such as wound repair and tissue remodeling. ..
  59. Genetics of Age-Related Macular Degeneration
    Michael Klein; Fiscal Year: 2007
    ..abstract_text> ..
  60. Postisoprenylation Processing and the Nuclear Lamina
    Stephen Young; Fiscal Year: 2007
    ..The third aim is to understand the posttranslational processing of lamin B1 and to define the consequences of lamin B1 deficiency in mammals. ..
  61. UCLA TRAINING PROGRAM IN NUTRITION AND OBESITY
    David Heber; Fiscal Year: 2007
    ..abstract_text> ..
  62. Omega-6 Fat Promotion of Mutant Kras-Induced Pancreatic Neoplasia
    Paul Grippo; Fiscal Year: 2008
    ..Results from this work will establish potential pathways that, when altered by drugs or changes in the diet, may prevent or retard the development of pancreatic cancer. [unreadable] [unreadable] [unreadable]..
  63. Maximization of anti-angiogenesis by thrombospondin-1
    Olga Volpert; Fiscal Year: 2008
    ..Such combined therapies present a promising new approach to the treatment of cancer and other angiogenesis dependent diseases. ..
  64. Regulation of angiogenic balance by thrombospondin-1.
    Olga Volpert; Fiscal Year: 2009
    ..These studies will yield new targets for therapeutic intervention using natural inhibitors. ..
  65. CYP1B1 and Retinopathy of Prematurity
    Nader Sheibani; Fiscal Year: 2010
    ..Understanding how CYP1 B1 and its metabolites regulate retinal vascular homeostasis will provide insight into CYP1 B1 mechanisms of action and aid in the development of alternative ways to modulate retinal angiogenesis. ..