PNKD

Summary

Gene Symbol: PNKD
Description: paroxysmal nonkinesigenic dyskinesia
Alias: BRP17, DYT8, FKSG19, FPD1, KIPP1184, MR-1, MR1, PDC, PKND1, TAHCCP2, brain protein 17, myofibrillogenesis regulator 1, trans-activated by hepatitis C virus core protein 2
Species: human

Top Publications

  1. ncbi Presence of alanine-to-valine substitutions in myofibrillogenesis regulator 1 in paroxysmal nonkinesigenic dyskinesia: confirmation in 2 kindreds
    Dong Hui Chen
    Department of Neurology, University of Washington, Seattle, 98195 7720, USA
    Arch Neurol 62:597-600. 2005
  2. ncbi The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway
    Hsien Yang Lee
    Department of Neurology, UCSF, San Francisco, CA, USA
    Hum Mol Genet 13:3161-70. 2004
  3. doi Paroxysmal non-kinesigenic dyskinesia is caused by mutations of the MR-1 mitochondrial targeting sequence
    Daniele Ghezzi
    Pierfranco and Luisa Mariani Center for the Study of Children s Mitochondrial Disorders, National Neurological Institute Carlo Besta, Milan, Italy
    Hum Mol Genet 18:1058-64. 2009
  4. ncbi Characterization of MR-1, a novel myofibrillogenesis regulator in human muscle
    Tian Bo Li
    Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050, China
    Acta Biochim Biophys Sin (Shanghai) 36:412-8. 2004
  5. ncbi Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activity
    S Ravindran
    Department of Biochemistry, Kansas State University, Manhattan 66506, USA
    J Biol Chem 271:653-62. 1996
  6. ncbi Parkinsonism, dementia and vertical gaze palsy in a Guamanian with atypical neuroglial degeneration
    K Oyanagi
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Acta Neuropathol 99:73-80. 2000
  7. ncbi Combination chemotherapy employing bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate tumors
    Marvin Rubenstein
    Division of Cellular Biology, Hektoen Institute for Medical Research, 2100 W Harrison Street, Chicago, IL 60612, USA
    Med Oncol 24:372-8. 2007
  8. doi Comparative study of the activity and kinetic properties of malate dehydrogenase and pyruvate decarboxylase from Candida albicans, Malassezia pachydermatis, and Saccharomyces cerevisiae
    Adam Tylicki
    Institute of Biology, University of Białystok, Swierkowa 20B, 15 950 Białystok, Poland
    Can J Microbiol 54:734-41. 2008
  9. pmc Sera from patients with tuberculosis recognize the M2a-epitope (E2-subunit of pyruvate dehydrogenase) specific for primary biliary cirrhosis
    R Klein
    Medizinische Klinik, University of Tubingen, Germany
    Clin Exp Immunol 92:308-16. 1993
  10. pmc The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle
    Paul A Roberts
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Physiol 545:297-304. 2002

Research Grants

Detail Information

Publications203 found, 100 shown here

  1. ncbi Presence of alanine-to-valine substitutions in myofibrillogenesis regulator 1 in paroxysmal nonkinesigenic dyskinesia: confirmation in 2 kindreds
    Dong Hui Chen
    Department of Neurology, University of Washington, Seattle, 98195 7720, USA
    Arch Neurol 62:597-600. 2005
    ..An autosomal dominant form of this disorder was mapped to chromosome 2q33-36, and different missense mutations in exon 1 of the myofibrillogenesis regulator 1 (MR1) gene were identified recently in 2 kindreds.
  2. ncbi The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway
    Hsien Yang Lee
    Department of Neurology, UCSF, San Francisco, CA, USA
    Hum Mol Genet 13:3161-70. 2004
    ..We report mutations in the myofibrillogenesis regulator 1 (MR-1) gene causing PNKD in 50 individuals from eight families...
  3. doi Paroxysmal non-kinesigenic dyskinesia is caused by mutations of the MR-1 mitochondrial targeting sequence
    Daniele Ghezzi
    Pierfranco and Luisa Mariani Center for the Study of Children s Mitochondrial Disorders, National Neurological Institute Carlo Besta, Milan, Italy
    Hum Mol Genet 18:1058-64. 2009
    Paroxysmal non-kinesigenic dyskinesia (PNKD) is an autosomal-dominant movement disorder characterized by attacks of dystonia, chorea and athetosis...
  4. ncbi Characterization of MR-1, a novel myofibrillogenesis regulator in human muscle
    Tian Bo Li
    Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050, China
    Acta Biochim Biophys Sin (Shanghai) 36:412-8. 2004
    ..These studies suggested that MR-1 might play a regulatory role in the muscle cell and it was worth investigating further...
  5. ncbi Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activity
    S Ravindran
    Department of Biochemistry, Kansas State University, Manhattan 66506, USA
    J Biol Chem 271:653-62. 1996
    To conserve carbohydrate reserves, the reaction of the pyruvate dehydrogenase complex (PDC) must be down-regulated when the citric acid cycle is provided sufficient acetyl-CoA...
  6. ncbi Parkinsonism, dementia and vertical gaze palsy in a Guamanian with atypical neuroglial degeneration
    K Oyanagi
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Acta Neuropathol 99:73-80. 2000
    ..The clinical diagnosis was parkinsonism-dementia complex (PDC) with vertical gaze palsy...
  7. ncbi Combination chemotherapy employing bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate tumors
    Marvin Rubenstein
    Division of Cellular Biology, Hektoen Institute for Medical Research, 2100 W Harrison Street, Chicago, IL 60612, USA
    Med Oncol 24:372-8. 2007
    ..we demonstrated that antisense oligonucleotides (oligos) against transforming growth factor-alpha (TGF-alpha [MR1]), its binding site the epidermal growth factor receptor (EGFR [MR2]), and the anti-apoptosis protein bcl-2 (MR4) ..
  8. doi Comparative study of the activity and kinetic properties of malate dehydrogenase and pyruvate decarboxylase from Candida albicans, Malassezia pachydermatis, and Saccharomyces cerevisiae
    Adam Tylicki
    Institute of Biology, University of Białystok, Swierkowa 20B, 15 950 Białystok, Poland
    Can J Microbiol 54:734-41. 2008
    ..We compare the properties of two enzymes, pyruvate decarboxylase (PDC) and malate dehydrogenase (MDH), from these species and from Saccharomyces cerevisiae cultivated under aerobic and ..
  9. pmc Sera from patients with tuberculosis recognize the M2a-epitope (E2-subunit of pyruvate dehydrogenase) specific for primary biliary cirrhosis
    R Klein
    Medizinische Klinik, University of Tubingen, Germany
    Clin Exp Immunol 92:308-16. 1993
    ..of the inner mitochondrial membrane consisting of six epitopes (E2 subunit of the pyruvate dehydrogenase complex (PDC), 70 kD; protein X of the PDC, 56 kD; alpha-ketoglutarate dehydrogenase complex, 52 kD; branched-chain alpha-..
  10. pmc The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle
    Paul A Roberts
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Physiol 545:297-304. 2002
    ..of adrenaline infusion on the activation status of glycogen phosphorylase and the pyruvate dehydrogenase complex (PDC) and on the accumulation of glucose-6-phosphate (G-6-P) and acetylcarnitine in resting canine skeletal muscle...
  11. pmc Genetic and biochemical characterization of a 2-pyrone-4, 6-dicarboxylic acid hydrolase involved in the protocatechuate 4, 5-cleavage pathway of Sphingomonas paucimobilis SYK-6
    E Masai
    Department of Bioengineering, Nagaoka University of Technology, Nagaoka, Niigata 940 2188, Japan
    J Bacteriol 181:55-62. 1999
    ..Yamasaki. J. Bacteriol. 172:2704-2709, 1990), we found the ligI gene encoding 2-pyrone-4, 6-dicarboxylic acid (PDC) hydrolase...
  12. ncbi Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis
    Tom J Sims
    Department of Oral Medicine, University of Washington, Seattle WA 98195, USA
    J Clin Periodontol 29:551-62. 2002
    ..decarboxylase autoantibody (GAD65 Ab) levels were significantly associated with periodontal pocket depth change (PDC) and 2. serum IgG titers to P...
  13. pmc The role of residues glutamate-50 and phenylalanine-496 in Zymomonas mobilis pyruvate decarboxylase
    J M Candy
    Department of Biochemistry, University of Queensland, Brisbane, Australia
    Biochem J 315:745-51. 1996
    ..thiamine diphosphate (ThDP) as an essential cofactor, and we have used one of these, pyruvate decarboxylase (PDC; EC 4.1.1.1) from Zymomonas mobilis, as a model for this group of enzymes...
  14. ncbi Tau-positive fine granules in the cerebral white matter: a novel finding among the tauopathies exclusive to parkinsonism-dementia complex of Guam
    Mineo Yamazaki
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu shi, Tokyo, Japan
    J Neuropathol Exp Neurol 64:839-46. 2005
    We examined the autopsied brains of cases of 6 types of tauopathy: parkinsonism-dementia complex of Guam (PDC), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), Pick disease, Alzheimer disease (AD), and myotonic ..
  15. doi Dendritic cells--at the front-line of pathogen attack
    Kenneth C McCullough
    Institute of Virology and Immunoprophylaxis, Research Department, Sensemattstrasse 293, CH 3147 Mittelhäusern, Switzerland
    Vet Immunol Immunopathol 128:7-15. 2009
    ..played by dendritic cells (DCs), particularly the interaction between conventional DC (cDC) and plasmacytoid DC (pDC), together with other monocytic cells...
  16. ncbi [Lessons from Guam ALS/PDC study]
    Hirano Asao
    Division of Neuropathology, Montefiore Medical Center, Bronx, New York 10467 2490, USA
    Rinsho Shinkeigaku 47:717-21. 2007
    An extraordinarily high incidence of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) affecting the native population was discovered on the island of Guam a half century ago...
  17. ncbi Bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate tumors
    Marvin Rubenstein
    Division of Cellular Biology, Hektoen Institute of Medicine, 2100 W Harrison Street, Chicago, IL, 60612, USA
    Med Oncol 24:189-96. 2007
    Antisense oligonucleotides (oligos) against transforming growth factor-alpha (TGF-alpha) (MR1) and its binding site, the epidermal growth factor receptor (EGFR) (MR2), are efficacious against PC-3 and LNCaP prostate tumors...
  18. ncbi Human plasmacytoid dendritic cells express receptors for anaphylatoxins C3a and C5a and are chemoattracted to C3a and C5a
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical School, Hannover, Germany
    J Invest Dermatol 126:2422-9. 2006
    The presence of plasmacytoid dendritic cells (pDC) was recently demonstrated in lesions of inflammatory skin diseases...
  19. pmc Characterization of a lipoyl domain-independent B-cell autoepitope on the human branched-chain acyltransferase in primary biliary cirrhosis and overlap syndrome with autoimmune hepatitis
    Antal Csepregi
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Street 1, 30625 Hannover, Germany
    Clin Dev Immunol 10:173-81. 2003
    Antimitochondrial antibodies (AMA) which recognize pyruvate acetyltransferase (PDC-E2) represent a highly diagnostic feature of primary biliary cirrhosis (PBC)...
  20. pmc Overproduction of threonine aldolase circumvents the biosynthetic role of pyruvate decarboxylase in glucose-limited chemostat cultures of Saccharomyces cerevisiae
    Antonius J A van Maris
    Kluyver Laboratory of Biotechnology, Delft University of Technology, The Netherlands
    Appl Environ Microbiol 69:2094-9. 2003
    Pyruvate decarboxylase-negative (Pdc(-)) mutants of Saccharomyces cerevisiae require small amounts of ethanol or acetate to sustain aerobic, glucose-limited growth...
  21. ncbi Systemic administration of anti-urokinase plasminogen activator receptor monoclonal antibodies induces hepatic fibrin deposition in tissue-type plasminogen activator deficient mice
    A Jogi
    Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark
    J Thromb Haemost 5:1936-44. 2007
    ..We have recently generated an inhibitory monoclonal antibody (mAb) against mouse u-PAR (mR1) by immunization of u-PAR-deficient mice.
  22. doi Beyond Guam: the cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases
    Walter G Bradley
    Department of Neurology, Miller School of Medicine, University of Miami, 1120 NW 14 Street, Miami, FL 33136, USA
    Amyotroph Lateral Scler 10:7-20. 2009
    ..Research on Guam suggested that ALS, Parkinson's disease and dementia (the ALS/PDC complex) was due to a neurotoxic non-protein amino acid, beta-methylamino-L-alanine (BMAA), in the seeds of the ..
  23. pmc Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction
    James A Timmons
    Department of Physiology and Pharmacology, Berzelius väg 13, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Physiol 561:851-9. 2004
    We previously established that activation of the pyruvate dehydrogenase complex (PDC) using dichloroacetate (DCA) reduced the reliance on substrate-level phosphorylation (SLP) at the onset of exercise, with normal and reduced blood flow...
  24. ncbi [Quantitation of antigen specific T lymphocytes in peripheral blood of patients with primary biliary cirrhosis using tetramer technology]
    Hai Ying Liu
    Clinical Laboratory, General Hospital of Guangzhou, Guangzhou 510010, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22:78-81. 2006
    ..To quantitate antigen specific T lymphocytes in peripheral blood from patients with primary biliary cirrhosis(PBC) and study the role of antigen specific T lymphocytes in the development of PBC...
  25. ncbi A study on the B cell activity in protein deficient rats exposed to methyl isocyanate vapour
    A K Saxena
    Immunobiology Lab, Industrial Toxicology Research Centre, Lucknow, India
    Immunopharmacol Immunotoxicol 13:413-24. 1991
    ..01) in the protein deficient diet fed control (PDC) ones...
  26. doi Preventive dental care for young, Medicaid-insured children in Washington state
    Charlotte Lewis
    Division of General Pediatrics, Department of Pediatrics, Child Health Institute, School of Public Health, University of Washington, Seattle, Washington 98195, USA
    Pediatrics 124:e120-7. 2009
    Children from low-income families face barriers to preventive dental care (PDC) and are disproportionately affected by dental caries...
  27. ncbi Site-specific phosphorylation of phosducin in intact retina. Dynamics of phosphorylation and effects on G protein beta gamma dimer binding
    Bruce Y Lee
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
    J Biol Chem 279:54008-17. 2004
    Phosducin (Pdc) is a G protein beta gamma dimer (G beta gamma) binding protein, highly expressed in retinal photoreceptor and pineal cells, yet whose physiological role remains elusive...
  28. doi Ca2+ -independent effects of spermine on pyruvate dehydrogenase complex activity in energized rat liver mitochondria incubated in the absence of exogenous Ca2+ and Mg2+
    E Pezzato
    Dipartimento di Chimica Biologica, Università di Padova e Istituto di Neuroscienze, CNR, Viale G Colombo 3, 35121 Padova, Italy
    Amino Acids 36:449-56. 2009
    ..of endogenous Ca(2+), the polyamine spermine is able to stimulate the activity of pyruvate dehydrogenase complex (PDC) of energized rat liver mitochondria (RLM)...
  29. ncbi Breakdown of tolerance to pyruvate dehydrogenase complex in experimental autoimmune cholangitis: a mouse model of primary biliary cirrhosis
    D E Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, UK
    Hepatology 30:65-70. 1999
    ..is characterized by autoreactive responses to a highly conserved self-antigen, pyruvate dehydrogenase complex (PDC)...
  30. pmc Double duty for a conserved glutamate in pyruvate decarboxylase: evidence of the participation in stereoelectronically controlled decarboxylation and in protonation of the nascent carbanion/enamine intermediate
    Danilo Meyer
    Albrecht von Haller Institute for Plant Sciences and Göttingen Center for Molecular Biosciences, Georg August University Gottingen, Ernst Caspari Haus, Justus von Liebig Weg 11, D 37077 Gottingen, Germany
    Biochemistry 49:8197-212. 2010
    Pyruvate decarboxylase (PDC) catalyzes the nonoxidative decarboxylation of pyruvate into acetaldehyde and carbon dioxide and requires thiamin diphosphate (ThDP) and a divalent cation as cofactors...
  31. ncbi Investigation of a mechanism for accelerated breakdown of immune tolerance to the primary biliary cirrhosis-associated autoantigen, pyruvate dehydrogenase complex
    David E J Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, United Kingdom
    Lab Invest 82:211-9. 2002
    ..by autoreactive T- and B-cell responses to the highly conserved enzyme pyruvate dehydrogenase complex (PDC). In this study we have examined the breakdown of T-cell tolerance to self-PDC using a mouse model...
  32. doi Results of a retrospective database analysis of adherence to statin therapy and risk of nonfatal ischemic heart disease in daily clinical practice in Italy
    Giovanni Corrao
    Department of Statistics, Unit of Biostatistics and Epidemiology, University of Milano Bicocca, Milan, Italy
    Clin Ther 32:300-10. 2010
    ..However, inadequate adherence may reduce statins' protective effects...
  33. ncbi Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate
    Nicholas E Simpson
    Department of Medicine, Division of Endocrinology and Metabolism, University of Florida, Gainesville, FL 32610, USA
    Mol Genet Metab 89:97-105. 2006
    The pyruvate dehydrogenase complex (PDC) is integral to metabolism and energetics. Congenital PDC deficiency leads to lactic acidosis, neurological degeneration and early death...
  34. ncbi Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy
    D E Jones
    Centre for Liver Research, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Liver 20:351-6. 2000
    ..Although auto-reactive immune responses against pyruvate dehydrogenase complex (PDC) have been characterised in PBC, the lack of an animal model of the disease has limited study of the mechanisms of ..
  35. doi Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
    Clin Gastroenterol Hepatol 6:1041-8. 2008
    ..in 95% of patients by autoantibody responses directed against the mitochondrial antigen pyruvate dehydrogenase complex (PDC). Although anti-PDC inhibits PDC function in vitro, mitochondrial function in vivo in PBC has not been examined.
  36. ncbi Bacterial motif DNA as an adjuvant for the breakdown of immune self-tolerance to pyruvate dehydrogenase complex
    David E J Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, England
    Hepatology 36:679-86. 2002
    ..the effects of CpG motif-containing oligodeoxynucleotides (ODN) on responses to pyruvate dehydrogenase complex (PDC, the autoantigen in PBC) in a murine model...
  37. pmc Apotopes and the biliary specificity of primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 49:871-9. 2009
    ..by antimitochondrial antibodies (AMAs), directed to the E2 component of the pyruvate dehydrogenase complex (PDC-E2)...
  38. ncbi Covalent modification as a mechanism for the breakdown of immune tolerance to pyruvate dehydrogenase complex in the mouse
    Jeremy M Palmer
    Centre for Liver Research, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Hepatology 39:1583-92. 2004
    ..PBC) is characterized by the breakdown of normal immune self tolerance to pyruvate dehydrogenase complex (PDC)...
  39. doi Identification of PDC-109-like protein(s) in buffalo seminal plasma
    Hiron M Harshan
    Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243122, India
    Anim Reprod Sci 115:306-11. 2009
    ..BSP-A1 and BSP-A2, the predominant proteins of the FN-2 family, are collectively termed as PDC-109...
  40. pmc Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation
    Nam Ho Jeoung
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Biochem J 397:417-25. 2006
    The PDC (pyruvate dehydrogenase complex) is strongly inhibited by phosphorylation during starvation to conserve substrates for gluconeogenesis...
  41. ncbi Localization and regulation of plasma membrane Ca(2+)-ATPase in bovine spermatozoa
    Jörg Triphan
    Department of Anatomy and Cell Biology, Philipps University, Robert Koch Str 8, D 35037 Marburg, Germany
    Eur J Cell Biol 86:265-73. 2007
    ..We have recently shown that bovine sperm PMCA is stimulated by PDC-109, a secretory protein of bovine seminal vesicles...
  42. doi Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway
    Hannah R Walden
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hepatology 48:1874-84. 2008
    Lipoylated enzymes such as the E2 component of pyruvate dehydrogenase complex (PDC-E2) are targets for autoreactive immune responses in primary biliary cirrhosis, with lipoic acid itself forming a component of the dominant auto-epitopes...
  43. doi The major protein of bovine seminal plasma, PDC-109, is a molecular chaperone
    Rajeshwer Singh Sankhala
    School of Chemistry, University of Hyderabad, Hyderabad 500046, India
    Biochemistry 49:3908-18. 2010
    The major protein of bovine seminal plasma, PDC-109, binds to choline phospholipids on the sperm plasma membrane and induces the efflux of cholesterol and choline phospholipids, which is an important step in sperm capacitation...
  44. doi Characterization of the p-coumaric acid decarboxylase from Lactobacillus plantarum CECT 748(T)
    Hector Rodriguez
    Departamento de Microbiologia, Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
    J Agric Food Chem 56:3068-72. 2008
    ..The p-coumaric acid decarboxylase (PDC) from this strain has been overexpressed and purified...
  45. ncbi Regulation of pyruvate dehydrogenase complex activity in Ehrlich ascites carcinoma cells by Ca2+ and pyruvate
    G L Ermakov
    Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142292, Russia
    Biochemistry (Mosc) 64:318-25. 1999
    The dependence of pyruvate dehydrogenase complex (PDC) activity on [Ca2+] was determined in Ehrlich ascites carcinoma cells at different pyruvate concentrations...
  46. pmc Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity
    R Max Wynn
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9038, USA
    J Biol Chem 283:25305-15. 2008
    Human pyruvate dehydrogenase complex (PDC) is down-regulated by pyruvate dehydrogenase kinase (PDK) isoforms 1-4. PDK4 is overexpressed in skeletal muscle in type 2 diabetes, resulting in impaired glucose utilization...
  47. ncbi Anti-CD25 mAb, anti-IL2 mAb, and IL2 block tolerance induction through anti-CD154 mAb and rapamycin in xenogeneic islet transplantation
    H Pan
    Department of General Surgery West China Hospital, Si Chuan University, Chengdu, Sichuan, China
    Transplant Proc 39:3452-4. 2007
    We have used anti-CD154 monoclonal antibody (mAb; MR1) and rapamycin (rapa) to induce tolerance to islet xenografts...
  48. ncbi Comparing adherence and persistence across 6 chronic medication classes
    Jason Yeaw
    IMS Health, 311 Arsenal St, Watertown, MA 02472, USA
    J Manag Care Pharm 15:728-40. 2009
    The National Quality Forum recently endorsed the proportion of days covered (PDC)-a measure of medication adherence-as an indicator of quality in drug therapy management.
  49. doi Circulating myeloid dendritic cells are increased in individuals with severe aplastic anemia
    Shao Zonghong
    Department of Hematology, General Hospital, Tianjin Medical University, 154 Anshandao, Tianjin 300052, Heping, People s Republic of China
    Int J Hematol 93:156-62. 2011
    ..of the study were to investigate the number of myeloid dendritic cells (mDC) and plasmacytoid dendritic cells (pDC) present in peripheral blood mononuclear cells (PBMC) from severe aplastic anemia (SAA) patients before and after ..
  50. ncbi Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis
    Akira Kawano
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Immunol 179:3315-24. 2007
    Primary biliary cirrhosis is characterized by autoreactive T cells specific for the mitochondrial Ag PDC-E2(163-176)...
  51. ncbi Peripheral blood T-cell responses to pyruvate dehydrogenase complex in primary biliary cirrhosis: role of antigen-presenting dendritic cells
    S M Akbar
    Ehime University School of Medicine, Ehime, Japan, Teikyo University Mizonokuchi Hospital, Kanagawa, Japan
    Eur J Clin Invest 31:639-46. 2001
    ..biliary cirrhosis (PBC) are usually characterized by the presence of antibody to pyruvate dehydrogenase complex (PDC) in the sera and PDC-specific T cells in the liver...
  52. ncbi Lack of promoting effects of the electromagnetic near-field used for cellular phones (929.2 MHz) on rat liver carcinogenesis in a medium-term liver bioassay
    K Imaida
    Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Carcinogenesis 19:311-4. 1998
    ..A 929.2-MHz electromagnetic near-field of time division multiple access (TDMA) signal for PDC (Personal Digital Cellular, Japanese cellular telephone standard) system was directed to rats through a quarter-..
  53. doi What Makes MAITs Wait?
    Mark A Exley
    Manchester Collaborative Center for Inflammation Research, University of Manchester, Manchester M13 9NT, UK Gastroenterology, Brigham and Women s Hospital, Harvard Medical School, Boston 02115, MA, USA Agenus, Inc, Lexington, MA 02421, USA Electronic address
    Immunity 44:7-9. 2016
    Mucosal-associated invariant T (MAIT) cells recognize microbial non-peptidic antigens presented by non-classical MHC MR1. In this issue of Immunity, Gherardin et al...
  54. ncbi Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer
    Evelyn Hartmann
    Department of Internal Medicine and Division of Clinical Pharmacology, Ludwig Maximilians University of Munich, Ziemssenstrasse 1, 80336 Munich, Germany
    Cancer Res 63:6478-87. 2003
    The antitumor activity of IFN-alpha is well established. However, the role of the plasmacytoid dendritic cell (PDC), the major producer of IFN-alpha upon viral infection, in tumor biology is unknown...
  55. pmc TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury
    Hong Z Yin
    Department of Neurology, University of California, Irvine, CA 92697 4292, USA
    Exp Neurol 238:93-102. 2012
    ..of either a low level of TNF-α, or of the glutamate uptake blocker, trans-pyrrolidine-2,4-dicarboxylic acid (PDC) to the cultures for 48 h resulted in little MN injury...
  56. ncbi Phosducin interacts with the G-protein betagamma-dimer of ciliate protozoan Blepharisma japonicum upon illumination
    Katarzyna Sobierajska
    Department of Cell Biology, Nencki Institute of Experimental Biology, 3 Pasteur Street, PL 02 093 Warsaw, Poland
    J Exp Biol 210:4213-23. 2007
    ..high-resolution FRET analysis were employed to investigate the in vivo colocalization and interaction of phosducin (Pdc) with the betagamma-subunits of G-protein (Gbetagamma) in the ciliate Blepharisma japonicum...
  57. pmc Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain
    Yiming Zhang
    Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivagen 10, 412 96, Goteborg, Sweden
    Microb Cell Fact 14:116. 2015
    A Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase (PDC) genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for the production of pyruvate derived biochemicals...
  58. doi Primary biliary cirrhosis following Lactobacillus vaccination for recurrent vaginitis
    Dimitrios Bogdanos
    Institute of Liver Studies, King s College, London School of Medicine at King s College Hospital, London, United Kingdom
    J Hepatol 49:466-73. 2008
    Antimitochondrial antibodies directed against the E2 subunit of the pyruvate dehydrogenase complex, PDC-E2, and other mitochondrial 2-oxoacid dehydrogenases (AMA-M2) are the hallmark for diagnosis of primary biliary cirrhosis (PBC)...
  59. ncbi The In-Situ One-Step Synthesis of a PDC Macromolecular Pro-Drug and the Fabrication of a Novel Core-Shell Micell
    Cui Yun Yu
    Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, 421001, China
    Curr Pharm Des 22:506-13. 2016
    ..Pectin-doxorubicin conjugates (PDC), a macromolecular pro-drug, were prepared via an amide condensation reaction, and a novel amphiphilic core-shell ..
  60. ncbi [Primary decompressive craniectomy in patients with aneurysmatic subarachnoid hemorrhage. Results of a pilot study in 11 cases]
    F Arikan
    Servicio de Neurocirugia, Unidad de Investigación de Neurotraumatología Neurocirugía Institut de Recerca Vall d Hebron, Barcelona, Spain
    Neurocirugia (Astur) 21:452-60. 2010
    ..This fact, together with the impressive results of the primary decompressive craniotomy (PDC) in the malignant infarction of the middle cerebral artery suggests a possible beneficial effect of decompressive ..
  61. doi TLR9 contributes to the recognition of EBV by primary monocytes and plasmacytoid dendritic cells
    Stéphanie Fiola
    Laboratory of Innate Immunology, Centre Hospitalier Universitaire de Quebec Research Center, Quebec City, Quebec, Canada
    J Immunol 185:3620-31. 2010
    ..In this study, we evaluated the ability of EBV to promote monocyte and plasmacytoid dendritic cell (pDC) activation and cytokine release through TLR9 activation...
  62. doi Dynamic accumulation of plasmacytoid dendritic cells in lymph nodes is regulated by interferon-beta
    Yunfei Gao
    Department of Immunology, University of Toronto, Toronto, ON, Canada
    Blood 114:2623-31. 2009
    ..that lymphocytes traffic through lymph nodes (LNs) to sample antigen, yet little is known about the dynamics of pDC accumulation within the secondary lymphoid organs...
  63. ncbi [Investigation of plasmacytoid dendritic cell reconstitution and its relationship with cGVHD and relapse after haploidentical hematopoietic stem cell transplantation]
    Ji Ying Wu
    Institute of Hematology and People Hospital, Peking University, Beijing 100044, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:342-7. 2007
    ..investigate the characteristics and significance of reconstitution of peripheral blood plasmacytoid dendritic cell (PDC) precursors after allogeneic human leukocyte antigen mismatched/haploidentical hematopoietic stem cell ..
  64. pmc New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle
    Francis B Stephens
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Physiol 581:431-44. 2007
    ..By increasing muscle pyruvate dehydrogenase complex (PDC) activity and acetylcarnitine content at rest, it has also been established that PDC flux and acetyl group ..
  65. doi Plasmacytoid DCs are gentle guardians of tonsillar epithelium
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Eur J Immunol 43:1142-6. 2013
    ..to be activated but to only produce TNF-α and IL-6, or to be activated and produce IFN-α, the hallmark of pDC activation, but only if the bacteria have first been opsonized...
  66. doi IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells
    Xin Zi Tang
    Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research, Singapore 117609
    J Immunol 190:3142-52. 2013
    ..characterized by the expression of a semi-invariant TCR capable of recognizing bacterial products in the context of MR1. MAIT cells are enriched in the human liver, which is constantly exposed to bacterial products from the intestine...
  67. ncbi Decreased expression of the thyroid-stimulating hormone receptor in poorly-differentiated carcinoma of the thyroid
    Hirofumi Matsumoto
    Department of Pathology, Kyorin University School of Medicine, Tokyo, Japan
    Oncol Rep 19:1405-11. 2008
    ..We comparatively studied their expression in 15 papillary carcinoma (PTC), 8 PDC and 8 UDC cases and further analyzed their correlation to proliferation activity as estimated by the MIB-1 index...
  68. pmc MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection
    Anda Meierovics
    Division of Bacterial, Parasitic, and Allergenic Products, Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 110:E3119-28. 2013
    ..an invariant T-cell receptor α-chain restricted by the nonclassical MHC class I molecule MHC-related protein 1 (MR1)...
  69. pmc Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer
    Xiao Mei Huang
    Department of Gastrointestinal Surgery, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China
    Cancer Sci 105:150-8. 2014
    ..In this study, we investigated pDCs and pDC-induced inducible costimulator (ICOS)(+) Treg populations in peripheral blood from gastric cancer (GC) patients and ..
  70. pmc Folding and hydrodynamics of a DNA i-motif from the c-MYC promoter determined by fluorescent cytidine analogs
    Samantha M Reilly
    Department of Chemistry and Biochemistry, University of Mississippi, University, Mississippi
    Biophys J 107:1703-11. 2014
    ..In the course of determining this folding pathway, we established that the fluorescent dC analogs tC° and PdC can be used to monitor individual residues of an iM structure and to determine the pKa of an iM...
  71. pmc Toward stable gene expression in CHO cells
    - Mariati
    a Bioprocessing Technology Institute Agency for Science, Technology, and Research A STAR Singapore, Republic of Singapore
    Bioengineered 5:340-5. 2014
    ..The modified hCMV with one copy of IE inserted between the hCMV enhancer and core promoter in reverse orientation (MR1) was most effective at enhancing expression stability in CHO cells without comprising expression level when ..
  72. doi Fusion of pyruvate decarboxylase and alcohol dehydrogenase increases ethanol production in Escherichia coli
    Aleksandra J Lewicka
    The University of Edinburgh, School of Biological Sciences, Darwin Building, King s Buildings, Mayfield Road, Edinburgh, EH9 3JR, United Kingdom
    ACS Synth Biol 3:976-8. 2014
    Ethanol is an important biofuel. Heterologous expression of Zymomonas mobilis pyruvate decarboxylase (Pdc) and alcohol dehydrogenase (AdhB) increases ethanol production in Escherichia coli...
  73. doi Improved conversion of cinnamaldehyde derivatives to diol compounds via a pyruvate decarboxylase-dependent mechanism in budding yeast
    Shunichi Miyakoshi
    National Institute of Technology, Gunma College, 580 Toriba machi, Maebashi, Gunma, 371 8530, Japan Electronic address
    J Biosci Bioeng 121:265-7. 2016
    ..cerevisiae carrying the pyruvate decarboxylase gene PDC1. As a result, condensation of the substrate with acetaldehyde was enhanced by PDC and flow to the diol product was altered.
  74. ncbi MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo
    Thomas Delale
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    J Immunol 175:6723-32. 2005
    ..release, which is initially (36 h) plasmacytoid dendritic cell- and MyD88-dependent, and subsequently (44 h) PDC-, MyD88-independent and, most likely, TLR-independent...
  75. pmc Plutonium(IV) reduction by the metal-reducing bacteria Geobacter metallireducens GS15 and Shewanella oneidensis MR1
    Hakim Boukhalfa
    Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Appl Environ Microbiol 73:5897-903. 2007
    ..investigates the ability of the metal-reducing bacteria Geobacter metallireducens GS15 and Shewanella oneidensis MR1 to enzymatically reduce freshly precipitated amorphous Pu(IV) (OH)(4) [Pu(IV)(OH)(4(am))] and soluble Pu(IV)(EDTA)...
  76. doi Post-transcriptional down-regulation of Toll-like receptor signaling pathway in umbilical cord blood plasmacytoid dendritic cells
    Emily Charrier
    Groupe de Recherche En Transplantation et Immunologie du Sang de Cordon, Centre de cancérologie Charles Bruneau, Centre de recherche du CHU Sainte Justine, 3175 chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada H3T 1C5
    Cell Immunol 276:114-21. 2012
    ..Comparing UCB PDC to their adults counterparts, we found that they exhibited a mature surface phenotype and a normal antigen uptake...
  77. doi Foxp3+ regulatory T cells are activated in spite of B7-CD28 and CD40-CD40L blockade
    Isabel Vogel
    Laboratory of Clinical Immunology, Faculty of Medicine, KU Leuven, Leuven, Belgium
    Eur J Immunol 43:1013-23. 2013
    ..When CTLA-4Ig and anti-CD40L mAb (MR1) were added to the cultures, T-cell proliferation and IL-2 production were strongly reduced...
  78. doi Mechanisms of survival prolongation of murine cardiac allografts using the treatment of CTLA4-Ig and MR1
    P Zhu
    Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Transplant Proc 40:1618-24. 2008
    ..corrected] The present study was undertaken to determine the role of costimulatory blockade in a murine cardiac transplant model...
  79. pmc A plasmacytoid dendritic cell (CD123+/CD11c-) based assay system to predict contact allergenicity of chemicals
    Seyoum Ayehunie
    MatTek Corporation, Ashland, MA 01721, United States
    Toxicology 264:1-9. 2009
    ..We investigated whether phenotypic and functional changes to a subset of dendritic cells (DC), plasmacytoid DC (pDC), could be used to identify contact allergens...
  80. doi Performance-based competencies for culturally responsive interprofessional collaborative practice
    Valerie Banfield
    Registered Nurses Professional Development Centre, Halifax, Nova Scotia, Canada
    J Interprof Care 23:611-20. 2009
    ..The Registered Nurses Professional Development Centre (RN-PDC), another PICE Project partner, has expertise in performance-based certification program design and utilizes a ..
  81. pmc The effects of poststroke captopril and losartan treatment on cerebral blood flow autoregulation in SHRsp with hemorrhagic stroke
    John S Smeda
    Division of Biomedical Sciences, Memorial University, Health Science Center, St John s, Newfoundland, Canada
    J Cereb Blood Flow Metab 31:476-85. 2011
    ..cerebral artery (MCA) perfusion domain and a pressure myograph was used to measure pressure-dependent constriction (PDC) in isolated MCAs before and after stroke and after 13, 33, and 63 days of poststroke captopril or losartan ..
  82. ncbi Chemerin and the recruitment of NK cells to diseased skin
    Joanna Skrzeczyńska-Moncznik
    Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Acta Biochim Pol 56:355-60. 2009
    ..In oral lichen planus lesions, the recruitment as well as intradermal colocalization of NK cells and pDC (plasmacytoid dendritic cells) appear to be mediated by chemerin, a recently identified protein ligand for ..
  83. doi Conversion of pyruvate decarboxylase into an enantioselective carboligase with biosynthetic potential
    Danilo Meyer
    Albrecht von Haller Institute for Plant Sciences and Göttingen Center for Molecular Biosciences, Georg August University Göttingen, Ernst Caspari Haus, Justus von Liebig Weg 11, D 37077 Göttingen, Germany
    J Am Chem Soc 133:3609-16. 2011
    Pyruvate decarboxylase (PDC) catalyzes the decarboxylation of pyruvate into acetaldehyde and CO(2) and requires the cofactors thiamin diphosphate and Mg(2+) for activity...
  84. ncbi [Immunoregulation by iNKT cells]
    Sachiko Miyake
    Department of Immunology, National Institute of Neuroscience, NCNP, Tokyo, Japan
    Yakugaku Zasshi 129:649-53. 2009
    ..2i NKT cells for human) are restricted by MR1 molecule. These cells emerge as an unique lymphocytes subset to bridge innate and acquired immunity...
  85. doi Viewpoint: factors involved in type I interferon responses during porcine virus infections
    Artur Summerfield
    Institute of Virology and Immunoprophylaxis, Sensemattstrasse 293, 3147 Mittelhäusern, Switzerland
    Vet Immunol Immunopathol 148:168-71. 2012
    ..One explanation for this observation is the presence of plasmacytoid dendritic cells (pDC), which are able to produce high levels of IFN-I despite the presence of viral IFN-I antagonists...
  86. doi Spinocerebellar ataxias type 27 derived from a disruption of the fibroblast growth factor 14 gene with mimicking phenotype of paroxysmal non-kinesigenic dyskinesia
    Keiko Shimojima
    Tokyo Women s Medical University Institute for Integrated Medical Sciences, Shinjuku Ward, Tokyo, Japan
    Brain Dev 34:230-3. 2012
    ..PNKD, since 60% of the patients with PNKD exhibit mutations in another gene responsible for PNKD, the myofibrillogenesis regulator 1 gene (MR-1)...
  87. pmc IFN-α is constitutively expressed in the human thymus, but not in peripheral lymphoid organs
    Arnaud D Colantonio
    Department of Microbiology, Immunology, and Molecular Genetics, David E Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e24252. 2011
    ..We show that pDC express the highest level of IFN-α and that MxA, which is exclusively expressed after engagement of the type I IFN ..
  88. pmc An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platform
    Jyh Chiang E Wang
    Human Immunology Center, David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol Methods 341:106-16. 2009
    ..ability of three major PBDC subsets (CD1c(+)CD11c(+) "MDC1," CD141(+)CD11c(+) "MDC2," and CD303(+)CD11c(-) "PDC") within a single platform. This method eliminates the need for DC enrichment, isolation, or prolonged culture...
  89. pmc HIV delays IFN-α production from human plasmacytoid dendritic cells and is associated with SYK phosphorylation
    Calvin C Lo
    Department of Immunology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e37052. 2012
    Plasmacytoid dendritic cells (pDC) are the major producers of type I interferons (IFNs) in humans and rapidly produce IFN-α in response to virus exposure...
  90. pmc Plasmacytoid dendritic cells promote immunosuppression in ovarian cancer via ICOS costimulation of Foxp3(+) T-regulatory cells
    Curdin Conrad
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cancer Res 72:5240-9. 2012
    ..of these cells were strictly dependent on ICOS-L costimulation provided by tumor plasmacytoid dendritic cells (pDC)...
  91. ncbi Evidence for a role of GABA- and glutamate-gated chloride channels in olfactory memory
    Katia Boumghar
    Centre de Recherches sur la Cognition Animale, Universite Paul Sabatier Toulouse III, CNRS UMR 5169, 118 route de Narbonne, 31062 Toulouse Cedex 4, France
    Pharmacol Biochem Behav 103:69-75. 2012
    ..GABAergic antagonist picrotoxin (PTX) or the GluCl antagonist L-trans-pyrrolidine-2,4-dicarboxylic acid (L-trans-PDC) was injected alone or in combination into the α-lobes of MBs...
  92. pmc Type I interferon-dependent gene MxA in perinatal HIV-infected patients under antiretroviral therapy as marker for therapy failure and blood plasmacytoid dendritic cells depletion
    Raffaele Badolato
    Istituto di Medicina Molecolare Angelo Nocivelli, Department of Pediatrics, University of Brescia, Brescia 25123, Italy
    J Transl Med 6:49. 2008
    ..in controlling HIV infection we phenotypically and functionally analyzed circulating plasmacytoid dendritic cells (pDC), which are known to be the highest interferon-alpha producing cells, in 33 perinatally infected HIV+ patients ..
  93. pmc Human spleen contains different subsets of dendritic cells and regulatory T lymphocytes
    M M Velásquez-Lopera
    Grupo de Inmunologia Celular e Inmunogenetica, Seccion de Dermatologia, Universidad de Antioquia, Medellin, Colombia
    Clin Exp Immunol 154:107-14. 2008
    ..5 +/- 0.8% and 1.0 +/- 1.6% immature CD11c(high)HLA-DR(+)CD83(-) cDC. There were 0.3 +/- 0.3% plasmacytoid DCs (pDC) CD11c(-/low)HLA-DR(+)CD123(high) and 0.3 +/- 0.1% LIN(-)HLA-DR(+)CD123(high)...
  94. doi Insights into a divergent phenazine biosynthetic pathway governed by a plasmid-born esmeraldin gene cluster
    Zhe Rui
    Department of Biological Science, Louisiana State University, Baton Rouge, LA 70803, USA
    Chem Biol 19:1116-25. 2012
    Phenazine-type metabolites arise from either phenazine-1-carboxylic acid (PCA) or phenazine-1,6-dicarboxylic acid (PDC). Although the biosynthesis of PCA has been studied extensively, PDC assembly remains unclear...
  95. doi Determination of arsenic in foods by flow injection on-line sorption pre-concentration with hydride generation atomic fluorescence spectrometry
    N Li
    Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science and Technology, Tianjin, Tianjin 300457, China
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 26:839-46. 2009
    ..was achieved through on-line formation and retention of the pyrrolidine dithiocarbamate arsenic complex (As(III)-PDC) on the cigarette filter, which was packed in the pre-concentration column and total arsenic was determined by HG-..
  96. ncbi Invariant V(alpha)19i T cells regulate autoimmune inflammation
    J Ludovic Croxford
    Department of Immunology, National Institute of Neuroscience, National Centre of Neurology and Psychiatry, Tokyo 187 8502, Japan
    Nat Immunol 7:987-94. 2006
    ..V(alpha)19i TCR) are restricted by the nonpolymorphic major histocompatibility complex class Ib molecule MR1. Whether V(alpha)19i T cells are involved in autoimmunity is not understood...
  97. ncbi Enzymatic (R)-phenylacetylcarbinol production in benzaldehyde emulsions
    B Rosche
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney NSW 2052, Australia
    Appl Microbiol Biotechnol 60:94-100. 2002
    ..batch biotransformation of benzaldehyde emulsions and pyruvate, using partially purified pyruvate decarboxylase (PDC) from the filamentous fungus Rhizopus javanicus NRRL 13161 as the catalyst...
  98. pmc Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis
    Sarah L Jongbloed
    Division of Immunology, Infection and Inflammation, 10 Alexandra Parade, Glasgow, G31 2ER, UK
    Arthritis Res Ther 8:R15. 2006
    ..Circulating peripheral blood (PB) pDC numbers were significantly reduced in PsA patients (P = 0.0098) and RA patients (P = 0...
  99. ncbi Metabolic engineering of a Lactobacillus plantarum double ldh knockout strain for enhanced ethanol production
    Siqing Liu
    Bioproducts and Biocatalysis Research Unit, National Center for Agriculture Utilization Research, USDA, ARS, 1815 N University St, Peoria, IL 61604, USA
    J Ind Microbiol Biotechnol 33:1-7. 2006
    ..By substituting LDH with pyruvate decarboxylase (PDC) activity, pyruvate may be redirected toward ethanol production instead of lactic acid fermentation...
  100. ncbi Promotion of long-term heart allograft survival by combination of mobilized donor plasmacytoid dendritic cells and anti-CD154 monoclonal antibody
    P Björck
    Department of Dermatology, University of Pittsburgh, Pennsylvania, USA
    J Heart Lung Transplant 24:1118-20. 2005
    ..The combination of pDC infusion with injection of anti-CD154 monoclonal antibody further inhibited graft rejection and, in 50% of the mice,..
  101. ncbi Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine production
    Nathalie Bendriss-Vermare
    Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
    J Leukoc Biol 78:954-66. 2005
    Depending on the activation status, plasmacytoid dendritic cells (PDC) and myeloid DC have the ability to induce CD4 T cell development toward T helper cell type 1 (Th1) or Th2 pathways...

Research Grants72

  1. MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2013
    ..AMAs), which react specifically with the lipoyl domain of the pyruvate dehydrogenase complex E2 subunit (PDC-E2)...
  2. Interactions of pDCs with Aspergilus
    STUART MICHAEL LEVITZ; Fiscal Year: 2013
    ..fumigatus-induced pDC death;2) following stimulation with A...
  3. Pathways regulating plasmacytoid dendritic cells in Peyers Patches
    Stephanie S Watowich; Fiscal Year: 2013
    ..The pDC developmental pathway proceeds through a common DC progenitor (CDP), which generates both pDCs and conventional DCs...
  4. HIV and Plasmacytoid dendritic cells in the thymus
    Christel Uittenbogaart; Fiscal Year: 2007
    Plasmacytoid dendritic cells (pDC) are lymphoid dendritic cells that express high levels of interleukin 3 (IL-3) receptor (CD 123) and produce type I interferons, cytokines with antiviral and immunoregulatory effects, pDC are present in ..
  5. The role of plasmacytoid dendritic cells in corneal immunity
    Pedram Hamrah; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Plasmacytoid dendritic cells (pDC), a distinct type of bone marrow-derived cell, play an important role in linking innate and adaptive immune responses...
  6. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..One type of DC, the plasmacytoid DC (PDC) is important in innate immune function through the production of interferon-? (IFN) induced by enveloped viruses ..
  7. IMPACT OF PLASMACYTOID DENDRITIC CELLS ON TYPE I DIABETES PATHOGENESIS
    Melissa Swiecki; Fiscal Year: 2013
    ..Plasmacytoid dendritic cells (pDC) have been identified as a major source of IFN-I in diabetic mouse models and an expansion of IFN-I-producing pDC ..
  8. Plasmacytoid Dendritic Cells in HIV Pathogenesis
    Patricia Fitzgerald-Bocarsly; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Plasmacytoid dendritic cells (pDC) are the most potent type I interferon (IFN)- producing cells in the body and are considered to be the "professional IFN producing cells"...
  9. Molecular Control of Plasmacytoid Dendritic Cell Development and Function
    Boris Reizis; Fiscal Year: 2013
    ..Virus-induced IFN production by pDCs is critical for the control of viral infections, whereas aberrant pDC activation is associated with autoimmune diseases...
  10. Post-transcriptional regulation of the Dendritic Cell transcriptome
    Miriam Merad; Fiscal Year: 2013
    ..that are specialized in the cross-presentation of cell associated antigens to CD8+ T cells, and plasmacytoid DC (pDC), which help to establish an antiviral state through the rapid secretion of high amounts of interferon alpha...
  11. Understanding the early and late endosomal TLR9-mediated responses to viral DNA.
    Yong Jun Liu; Fiscal Year: 2013
    ..The first aim will focus on the potential role of in CpG ODN trafficking by using a human pDC cell line with stable knockdown of PACSIN1 expression by shRNA and mouse pDCs derived from PACSIN-deficient mice...
  12. Plasmacytoid DC Interactions in the Generation of an Antitumor Immune Response
    Patrick Hwu; Fiscal Year: 2010
    ..In our preliminary studies, we found that activated, antigen-pulsed, pDC and mDC could individually stimulate antigen-specific CTL responses in mice...
  13. T cell depletion in older HIV-infected patients by plasmacytoid dendritic cells
    VIRIAN DAVY SEREI; Fiscal Year: 2013
    ..Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons and are also known to express TRAIL during HIV infection...
  14. Effect of Atopy on Dendritic Cell Antiviral Responses
    Michelle A Gill; Fiscal Year: 2013
    ..Moreover, in vitro pDC IFN responses to virus are inhibited by IgE-dependent mechanisms...
  15. The Role of C-C Chemokines in Eosinophil Airway Inflammation
    Nicholas W Lukacs; Fiscal Year: 2012
    ..To identify the differential role of chemokines for DC subset, pDC vs. cDC, trafficking to the lungs and activation leading to altered pulmonary responses...
  16. Innate immune mechanisms in dengue infection
    Kovit Pattanapanyasat; Fiscal Year: 2013
    ..with Fas-L expressing NK cells c) there is a marked increase in the frequencies of plamacytoid dendritic cells (pDC's) which express immature phenotype d) there is a muted memory B cell response against the heterologous dengue ..
  17. HIV Dysregulation of Human Plasmacytoid Dendritic Cells
    MEAGAN O'BRIEN; Fiscal Year: 2013
    ..candidate's proposed research project centers on the idea that HIV dysregulates plasmacytoid dendritic cells (pDC) to activate deficient adaptive immune responses while stimulating persistent interferon-alpha (IFNa) production, ..
  18. Modulating anti-HIV immunity by plasmacytoid dendritic cells
    Nina Bhardwaj; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human plasmacytoid dendritic cells (pDC) constitute a rare subset of blood dendritic cells (DC), distinct from myeloid CD11c+, "conventional" DC (cDC)...
  19. The Role of Type III Interferon in Innate Immunity to Respiratory Virus Infection
    Joan E Durbin; Fiscal Year: 2010
    ..3) Characterize production of, and responsiveness to, type I and type III IFNs by polarized airway epithelial cells. 4) Determine the role of IFN-lambda in pDC maturation and function during influenza virus infection.
  20. Modulating anti-HIV immunity by plasmacytoid dendritic cells
    Melissa Victoria Fernandez; Fiscal Year: 2013
    ABSTRACT Human plasmacytoid dendritic cells (pDC) constitute a rare subset of blood dendritic cells (DC), distinct from myeloid CD11c+, [unreadable]conventional[unreadable] DC (cDC)...
  21. Viral Gastroenteritis: Basis of Protection and Virulence
    HARRY BERNARD GREENBERG; Fiscal Year: 2013
    ..the interaction of murine plasmacytoid dendritic cells (pDCs) with RV and determine the contribution of pDC-derived interferon to restricting RV infection...
  22. Immune function and the progression to type 1 diabetes
    Mark A Atkinson; Fiscal Year: 2013
    ..defects in type 1 IFN biology, hyperactive IFN[unreadable]/[unreadable] responses and increased plasmacytoid DC (PDC)/IFN[unreadable]/[unreadable] production in the islet microenvironment play a critical role in T1D pathogenesis...
  23. Autophagy in Antiviral Immunity
    Akiko Iwasaki; Fiscal Year: 2013
    ..In professional viral sensors, the plasmacytoid dendritic cells (pDC), recognition of viruses occurs in the endosomes via Toll-like receptors (TLR) 7 and 9...
  24. Dissecting Dendritic Cell Function in Autoimmune Diabetes
    JONATHAN DAVID KATZ; Fiscal Year: 2013
    ..Conversely, depleting plasmacytoid DC (pDC) exacerbates the pathology- increasing both the number and severity of infiltrated islets, suggesting that, once ..
  25. AAV-Based Plasmacytoid Dendritic Cell Cancer Vaccine
    Pierre L Triozzi; Fiscal Year: 2010
    ..There is experimental evidence suggesting that the plasmacytoid DC subpopulation (pDC) plays an important role in regulating the T-helper (Th) polarization of the immune response...
  26. IDO-expressing immunoregulatory dendritic cells
    David H Munn; Fiscal Year: 2013
    ..murine models have: (i) elucidated the identity of the novel subset of plasmacytoid dendritic cell (pDC) in tumor-draining lymph nodes that express IDO;(ii) identified the downstream molecular pathway in T cells by ..
  27. Migration and Trafficking in Tolerance 10/07
    Jonathan S Bromberg; Fiscal Year: 2012
    ..now demonstrate that during tolerization there is alloantigen specific clustering of T cells and plasmacytoid DC (pDC) in the T cell areas of the lymph node (LN) near the abluminal surface of the high endothelial venules (HEV)...
  28. A Novel Tolergenic Dendritic Cell: Biology &Therapeutic Potential
    Eugene C Butcher; Fiscal Year: 2013
    ..Preliminary studies show that CCR9+ DCs are a subset of immature plasmacytoid DC (pDC), and have provided initial insights leading to the following general hypotheses: 1...
  29. HCV, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2013
    ..We hypothesize that HCV-mediated signals play a role in HCV-induced alterations in dendritic cells (mDCI, mDC2, pDC) and contribute to the reduced T cell responses in HCV infection by induction of CD4+CD25+ regulatory T cells...
  30. Induction and Migration of Regulatory T Cells
    Jonathan S Bromberg; Fiscal Year: 2013
    ..where they are stimulated in the cortical area by specific alloantigen presenting plasmacytoid dendritic cells (pDC) to generate adaptive or induced Treg (aTreg)...
  31. Targeting Plasmacytoid Dendritic Cells to Treat Human Myeloma
    Qing Yi; Fiscal Year: 2013
    ..However, several recent studies have also identified pDC as critical players in oral and airway tolerance...
  32. Plasmacytoid Dendritic Cells and Their Role in Transplant Tolerance
    Audrey H Lau; Fiscal Year: 2013
    ..It has been hypothesized that immature pDC are inherently tolerogenic...
  33. Aging with Chronic Viral Infections and the Impact on Innate Immune Responses
    HEATHER WINONA STOUT-DELGADO; Fiscal Year: 2013
    ..The goal of this proposal is to examine the effects of chronic viral infection on pDC cell function and how these effects contribute to viral persistence and susceptibility to a secondary infection...
  34. Role of dendritic cells in resistance to Toxoplasma.
    Christopher A Hunter; Fiscal Year: 2010
    ..Unexpectedly, parallel work identified plasmacytoid DC (pDC), a newly described DC subset, as a prominent cell type involved in the development of T helper cell responses to ..
  35. Activation of Plasmacytoid Dendritic Cells (pDCs) to Induce Antitumor Activity
    Patrick Hwu; Fiscal Year: 2012
    ..In Project 2, further characterization of pDC interactions will be performed in a murine tumor model...
  36. Role of plasmacytoid dendritic cells in human metapneumo virus infection
    MARIA ANTONIETA GUERRERO-PLATA; Fiscal Year: 2011
    ..Based on preliminary data from our group, we will test the hypothesis that lung plasmacytoid dendritic cells (pDC), critical immune cells in mediating antiviral response, play a major role in controlling hMPV-induced lung ..
  37. Effect of HIV and IL28B on NK control of HCV
    Donald D Anthony; Fiscal Year: 2013
    ..Plasmacytoid dendritic cells (pDC) produce IFN-alpha during viral infection, and directly activate NK cells...
  38. Role of Peripheral Dendritic Cells in Central and Oral Tolerance
    Husein Hadeiba; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We have identified a potent tolerogenic plasmacytoid dendritic cell (pDC) population defined by expression of the chemokine receptor CCR9, and have shown that these CCR9+ pDCs not only induce ..
  39. Role of IL28B and HIV in NK Control of HCV
    Donald D Anthony; Fiscal Year: 2013
    ..Plasmacytoid dendritic cells (pDC) produce IFN-a during viral infection, and directly activate NK cells...
  40. The Role of miRNA in Dendritic Cell Function
    GREGORY MULLOKANDOV; Fiscal Year: 2013
    ..Plasmacytoid DC (pDC) is a major subset of DCs and are one of the earliest defenses of the body against specific pathogens...
  41. Cellular innate activation as a tactic to prevent HIV-1 transmission
    LUIS J contact MONTANER; Fiscal Year: 2010
    ..We will collect both direct and indirect correlative data to test the hypothesis that plasmacytoid dendritic cells (pDC) recruitment and activation into the cervicovaginal compartment by HIV-1 particles or infected cells not resulting ..
  42. IFN-a and pDC in HIV infection: impact on T cell development and reconstitution
    Christel H Uittenbogaart; Fiscal Year: 2013
    ..In addition we found that in normal thymus tissue, mature thymocytes and plasmacytoid dendritic cells (pDC) constitutively express IFN-?? and its secondary response protein MxA at low levels...
  43. Characterizing DExD/H box helicases as viral sensors in human dendritic cells
    Yong Jun Liu; Fiscal Year: 2013
    ..Knocking down DHX36 expression by siRNA in a pDC cell line was associated with over 50% reduction in type 1 IFN responses and abolished IRF7 nuclear translocation ..
  44. Antigen Recognition at Epithelial Interphases
    Hans Christian Reinecker; Fiscal Year: 2013
    ..We have identified a mucosal plasmacytoid dendritic cell (pDC) subset that has a critical role in limiting intestinal inflammation thereby promoting tissue reconstruction and ..
  45. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..The activity of the pyruvate dehydrogenase complex (PDC) is tightly regulated by phosphorylation by the PDKs...
  46. Immunogenetic Control of Autoimmune Liver Disease
    William M Ridgway; Fiscal Year: 2013
    ..ABD" mice) that develop spontaneous, autoimmune biliary disease (ABD) and anti-pyruvate dehydrogenase complex (PDC) autoantibodies, and serve as a model of human primary biliary cirrhosis (PBC)...
  47. Retrovirus Isolation from Primary Biliary Cirrhosis
    Andrew Mason; Fiscal Year: 2004
    ..of patients develop anti-mitochondrial antibodies (AMA) reactive to pyruvate dehydrogenase complex E2 component (PDC-E2), which is aberrantly expressed on cell surface of biliary epithelial cells of patients with PBC...
  48. CHARACTERIZATION OF A NEW FAMILY OF PROTEIN KINASES
    Kirill M Popov; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The reaction catalyzed by mitochondrial pyruvate dehydrogenase complex (PDC) links glycolysis and Citric Acid Cycle...
  49. Novel mechanisms of mitochondrial regulation by sirtuin deacetylases
    DAVID BENNER LOMBARD; Fiscal Year: 2013
    ..plays a hitherto undescribed role in deacetylating and suppressing activity of Pyruvate Dehydrogenase Complex (PDC), a mitochondrial holoenzyme with a major role in regulating glucose oxidation in mammalian cells...
  50. Diabetic Cardiomyopathy
    Wolfgang H Dillmann; Fiscal Year: 2011
    ..Studies of Aim III are directed at increasing the activity of the pyruvate dehydrogenase complex (PDC) of the D heart and enhancing glucose oxidation (ox)...
  51. Regulation of Energy Metabolism by PDP1 and PDP2
    Kirill M Popov; Fiscal Year: 2012
    ..understand the molecular mechanisms responsible for the regulation of mitochondrial pyruvate dehydrogenase complex (PDC)...
  52. INBORN ERRORS OF METABOLISM IN CELL CULTURE
    David T Chuang; Fiscal Year: 2010
    ..comprises the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), the pyruvate dehydrogenase complex (PDC) and the alpha-ketoglutarate dehydrogenase complex (KGDC)...
  53. INBORN ERRORS OF PYRUVATE METABOLISM
    Mulchand Patel; Fiscal Year: 1999
    The pyruvate dehydrogenase complex (PDC) plays a pivotal role in the metabolism of pyruvate for energy production and for biosynthetic processes...
  54. VOLATILE ACID FORMATION IN PARASITIC HELMINTHS
    Richard Komuniecki; Fiscal Year: 2004
    ..novel anaerobic mitochondria present in the parasitic nematode, Ascaris suum: The pyruvate dehydrogenase complex (PDC) plays a key role in regulating these anaerobic mitochondrial pathways and its regulation and subunit composition ..
  55. INBORN ERRORS OF THE PYRUVATE DEHYDROGENASE COMPLEX
    Isaiah Wexler; Fiscal Year: 1993
    The aim of the proposed project is to identify and analyze mutations responsible for pyruvate dehydrogenase complex (PDC) deficiency, an inherited disorder of energy metabolism which causes lactic acidosis and neurologic disability...
  56. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2013
    ..occurs due to the loss of CD4 T cells and type I interferon (type-I-IFN) producing plasmacytoid dendritic cell (pDC). These infections contribute greatly to morbidity and mortality...
  57. The endosomal SLC15A4 proton-coupled histidine transporter in lupus
    Argyrios N Theofilopoulos; Fiscal Year: 2013
    ..Among the innate immune cells implicated in the pathogenesis of lupus is the plasmacytoid dendritic cell (pDC) which constitute a small (<1%), but distinct population of cells that is thought to be activated by nucleic ..
  58. Mechanisms of dysregulated immunity with aging.
    DANIEL ROBERT GOLDSTEIN; Fiscal Year: 2013
    ..by using murine models to determine 1) if exaggerated inflammatory responses by NKT cells coupled to defective pDC responses are critical for the generation of IL-17 anti-viral CD4+ T cells during systemic herpes viral infections ..
  59. Novel Mucosa-homing Dendritic Cell: Development, Trafficking and Function
    Eugene C Butcher; Fiscal Year: 2013
    ..progenitors of intestinal DC populations including CD103+ cDC;and they can also give rise to CCR9+ plasmacytoid DC (pDC)...
  60. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2013
    ..by breach of tolerance to the major mitochondrial autoantigen, the E2 component of pyruvate dehydrogenase (PDC-E2)...
  61. NK Cell Activation and Function in HIV-1 Exposed Uninfected IV Drug Users
    David W Speicher; Fiscal Year: 2013
    ..The effects of drug use on NK or PDC activation programs, even in the absence of repeated HIV exposure, are also unknown...
  62. MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..at the apical surface of BECs, which reacts with autoantibodies specific for the major mitochondrial autoantigens, PDC-E2, BCOADC-E2, and OGDC-E2. Such localization prompts us to propose three specific issues...
  63. HIV and Plasmacytoid dendritic cells in the thymus
    Christel Uittenbogaart; Fiscal Year: 2002
    Plasmacytoid dendritic cells (pDC) or natural interferon type I producing cells play an important role in linking innate and acquired immunity...
  64. REGULATION OF MAMMALIAN PYRUVATE DEHYDROGENASE
    THOMAS ROCHE; Fiscal Year: 2004
    The mammalian pyruvate dehydrogenase complex (PDC) connects glycolysis to oxidative metabolism and fatty acid synthesis with the irretrievable loss of glucose carbons...
  65. REGULATION OF MAMMALIAN DIHYDROLIPOAMIDE DEHYDROGENASE
    Mulchand Patel; Fiscal Year: 2002
    ..In eukaryotic pyruvate dehydrogenase complex (PDC), E3 binds to an E3-binding protein (E3BP)...
  66. 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASE
    JAMES STOOPS; Fiscal Year: 2001
    ..Mammalian pyruvate dehydrogenase complex (PDC) plays a critical role in regulating cellular fuel utilization in the heart and, therefore, studies of the ..
  67. 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASE
    JAMES STOOPS; Fiscal Year: 2002
    ..Mammalian pyruvate dehydrogenase complex (PDC) plays a critical role in regulating cellular fuel utilization in the heart and, therefore, studies of the ..
  68. GENETIC ANALYSIS OF PAROXYSMAL DYSTONIC CHOREOATHETOSIS
    John Fink; Fiscal Year: 2000
    ..The principal investigator proposes to study paroxysmal dystonic choreoathetosis (PDC), an inherited disorder characterized by attacks of involuntary movements that occur spontaneously at rest and ..
  69. Targeting pDCs for the Generation of Effective Anti-HCV CD8+ T-Cell Immunity
    John Connolly; Fiscal Year: 2009
    ..Furthermore we have demonstrated that targeting antigens to this compartment in an activated pDC is sufficient to initiate potent CD8+ T-cell responses...
  70. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2001
    ..AMAs are directed at the E2 components of the 2-oxo acid dehydrogenase pathway, particularly PDC-E2; 95 percent of patients with PBC have a positive AMA...
  71. A Revolutionary Therapy for Atherosclerosis: Liquid Cast Arterial Stents
    Guillermo A Ameer; Fiscal Year: 2010
    ..We will use a biocompatible elastomeric citric acid-based polymer, polydiolcitrate (PDC) that will be diazeniumdiolated to spontaneously release nitric oxide (NO) when placed in the circulation...
  72. Phytoestrogen and Antioxidant Regulation of Prostate Cancer
    Dennis Lubahn; Fiscal Year: 2009
    ..Exciting data from our model clearly show that ERalphaKO mice are highly protected against PDC (poorly differentiated carcinoma) of the prostate and ERbetaKO mice are highly susceptible to PDC...