PNKD

Summary

Gene Symbol: PNKD
Description: paroxysmal nonkinesigenic dyskinesia
Alias: BRP17, DYT8, FPD1, KIPP1184, MR-1, MR1, PDC, PKND1, TAHCCP2, brain protein 17, myofibrillogenesis regulator 1, trans-activated by hepatitis C virus core protein 2
Species: human

Top Publications

  1. ncbi Presence of alanine-to-valine substitutions in myofibrillogenesis regulator 1 in paroxysmal nonkinesigenic dyskinesia: confirmation in 2 kindreds
    Dong Hui Chen
    Department of Neurology, University of Washington, Seattle, 98195 7720, USA
    Arch Neurol 62:597-600. 2005
  2. ncbi The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway
    Hsien Yang Lee
    Department of Neurology, UCSF, San Francisco, CA, USA
    Hum Mol Genet 13:3161-70. 2004
  3. ncbi Paroxysmal non-kinesigenic dyskinesia is caused by mutations of the MR-1 mitochondrial targeting sequence
    Daniele Ghezzi
    Pierfranco and Luisa Mariani Center for the Study of Children s Mitochondrial Disorders, National Neurological Institute Carlo Besta, Milan, Italy
    Hum Mol Genet 18:1058-64. 2009
  4. ncbi Characterization of MR-1, a novel myofibrillogenesis regulator in human muscle
    Tian Bo Li
    Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050, China
    Acta Biochim Biophys Sin (Shanghai) 36:412-8. 2004
  5. ncbi Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activity
    S Ravindran
    Department of Biochemistry, Kansas State University, Manhattan 66506, USA
    J Biol Chem 271:653-62. 1996
  6. ncbi Parkinsonism, dementia and vertical gaze palsy in a Guamanian with atypical neuroglial degeneration
    K Oyanagi
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Acta Neuropathol 99:73-80. 2000
  7. ncbi Combination chemotherapy employing bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate tumors
    Marvin Rubenstein
    Division of Cellular Biology, Hektoen Institute for Medical Research, 2100 W Harrison Street, Chicago, IL 60612, USA
    Med Oncol 24:372-8. 2007
  8. ncbi Comparative study of the activity and kinetic properties of malate dehydrogenase and pyruvate decarboxylase from Candida albicans, Malassezia pachydermatis, and Saccharomyces cerevisiae
    Adam Tylicki
    Institute of Biology, University of Białystok, Swierkowa 20B, 15 950 Białystok, Poland
    Can J Microbiol 54:734-41. 2008
  9. pmc Sera from patients with tuberculosis recognize the M2a-epitope (E2-subunit of pyruvate dehydrogenase) specific for primary biliary cirrhosis
    R Klein
    Medizinische Klinik, University of Tubingen, Germany
    Clin Exp Immunol 92:308-16. 1993
  10. pmc The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle
    Paul A Roberts
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Physiol 545:297-304. 2002

Detail Information

Publications144 found, 100 shown here

  1. ncbi Presence of alanine-to-valine substitutions in myofibrillogenesis regulator 1 in paroxysmal nonkinesigenic dyskinesia: confirmation in 2 kindreds
    Dong Hui Chen
    Department of Neurology, University of Washington, Seattle, 98195 7720, USA
    Arch Neurol 62:597-600. 2005
    ..An autosomal dominant form of this disorder was mapped to chromosome 2q33-36, and different missense mutations in exon 1 of the myofibrillogenesis regulator 1 (MR1) gene were identified recently in 2 kindreds.
  2. ncbi The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway
    Hsien Yang Lee
    Department of Neurology, UCSF, San Francisco, CA, USA
    Hum Mol Genet 13:3161-70. 2004
    ..We report mutations in the myofibrillogenesis regulator 1 (MR-1) gene causing PNKD in 50 individuals from eight families...
  3. ncbi Paroxysmal non-kinesigenic dyskinesia is caused by mutations of the MR-1 mitochondrial targeting sequence
    Daniele Ghezzi
    Pierfranco and Luisa Mariani Center for the Study of Children s Mitochondrial Disorders, National Neurological Institute Carlo Besta, Milan, Italy
    Hum Mol Genet 18:1058-64. 2009
    Paroxysmal non-kinesigenic dyskinesia (PNKD) is an autosomal-dominant movement disorder characterized by attacks of dystonia, chorea and athetosis...
  4. ncbi Characterization of MR-1, a novel myofibrillogenesis regulator in human muscle
    Tian Bo Li
    Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050, China
    Acta Biochim Biophys Sin (Shanghai) 36:412-8. 2004
    ..These studies suggested that MR-1 might play a regulatory role in the muscle cell and it was worth investigating further...
  5. ncbi Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activity
    S Ravindran
    Department of Biochemistry, Kansas State University, Manhattan 66506, USA
    J Biol Chem 271:653-62. 1996
    To conserve carbohydrate reserves, the reaction of the pyruvate dehydrogenase complex (PDC) must be down-regulated when the citric acid cycle is provided sufficient acetyl-CoA...
  6. ncbi Parkinsonism, dementia and vertical gaze palsy in a Guamanian with atypical neuroglial degeneration
    K Oyanagi
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Acta Neuropathol 99:73-80. 2000
    ..The clinical diagnosis was parkinsonism-dementia complex (PDC) with vertical gaze palsy...
  7. ncbi Combination chemotherapy employing bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate tumors
    Marvin Rubenstein
    Division of Cellular Biology, Hektoen Institute for Medical Research, 2100 W Harrison Street, Chicago, IL 60612, USA
    Med Oncol 24:372-8. 2007
    ..we demonstrated that antisense oligonucleotides (oligos) against transforming growth factor-alpha (TGF-alpha [MR1]), its binding site the epidermal growth factor receptor (EGFR [MR2]), and the anti-apoptosis protein bcl-2 (MR4) ..
  8. ncbi Comparative study of the activity and kinetic properties of malate dehydrogenase and pyruvate decarboxylase from Candida albicans, Malassezia pachydermatis, and Saccharomyces cerevisiae
    Adam Tylicki
    Institute of Biology, University of Białystok, Swierkowa 20B, 15 950 Białystok, Poland
    Can J Microbiol 54:734-41. 2008
    ..We compare the properties of two enzymes, pyruvate decarboxylase (PDC) and malate dehydrogenase (MDH), from these species and from Saccharomyces cerevisiae cultivated under aerobic and ..
  9. pmc Sera from patients with tuberculosis recognize the M2a-epitope (E2-subunit of pyruvate dehydrogenase) specific for primary biliary cirrhosis
    R Klein
    Medizinische Klinik, University of Tubingen, Germany
    Clin Exp Immunol 92:308-16. 1993
    ..of the inner mitochondrial membrane consisting of six epitopes (E2 subunit of the pyruvate dehydrogenase complex (PDC), 70 kD; protein X of the PDC, 56 kD; alpha-ketoglutarate dehydrogenase complex, 52 kD; branched-chain alpha-..
  10. pmc The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle
    Paul A Roberts
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Physiol 545:297-304. 2002
    ..of adrenaline infusion on the activation status of glycogen phosphorylase and the pyruvate dehydrogenase complex (PDC) and on the accumulation of glucose-6-phosphate (G-6-P) and acetylcarnitine in resting canine skeletal muscle...
  11. pmc Genetic and biochemical characterization of a 2-pyrone-4, 6-dicarboxylic acid hydrolase involved in the protocatechuate 4, 5-cleavage pathway of Sphingomonas paucimobilis SYK-6
    E Masai
    Department of Bioengineering, Nagaoka University of Technology, Nagaoka, Niigata 940 2188, Japan
    J Bacteriol 181:55-62. 1999
    ..Yamasaki. J. Bacteriol. 172:2704-2709, 1990), we found the ligI gene encoding 2-pyrone-4, 6-dicarboxylic acid (PDC) hydrolase...
  12. ncbi Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis
    Tom J Sims
    Department of Oral Medicine, University of Washington, Seattle WA 98195, USA
    J Clin Periodontol 29:551-62. 2002
    ..decarboxylase autoantibody (GAD65 Ab) levels were significantly associated with periodontal pocket depth change (PDC) and 2. serum IgG titers to P...
  13. pmc The role of residues glutamate-50 and phenylalanine-496 in Zymomonas mobilis pyruvate decarboxylase
    J M Candy
    Department of Biochemistry, University of Queensland, Brisbane, Australia
    Biochem J 315:745-51. 1996
    ..thiamine diphosphate (ThDP) as an essential cofactor, and we have used one of these, pyruvate decarboxylase (PDC; EC 4.1.1.1) from Zymomonas mobilis, as a model for this group of enzymes...
  14. ncbi Dendritic cells--at the front-line of pathogen attack
    Kenneth C McCullough
    Institute of Virology and Immunoprophylaxis, Research Department, Sensemattstrasse 293, CH 3147 Mittelhäusern, Switzerland
    Vet Immunol Immunopathol 128:7-15. 2009
    ..played by dendritic cells (DCs), particularly the interaction between conventional DC (cDC) and plasmacytoid DC (pDC), together with other monocytic cells...
  15. ncbi Tau-positive fine granules in the cerebral white matter: a novel finding among the tauopathies exclusive to parkinsonism-dementia complex of Guam
    Mineo Yamazaki
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu shi, Tokyo, Japan
    J Neuropathol Exp Neurol 64:839-46. 2005
    We examined the autopsied brains of cases of 6 types of tauopathy: parkinsonism-dementia complex of Guam (PDC), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), Pick disease, Alzheimer disease (AD), and myotonic ..
  16. ncbi [Lessons from Guam ALS/PDC study]
    Hirano Asao
    Division of Neuropathology, Montefiore Medical Center, Bronx, New York 10467 2490, USA
    Rinsho Shinkeigaku 47:717-21. 2007
    An extraordinarily high incidence of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) affecting the native population was discovered on the island of Guam a half century ago...
  17. ncbi Bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate tumors
    Marvin Rubenstein
    Division of Cellular Biology, Hektoen Institute of Medicine, 2100 W Harrison Street, Chicago, IL, 60612, USA
    Med Oncol 24:189-96. 2007
    Antisense oligonucleotides (oligos) against transforming growth factor-alpha (TGF-alpha) (MR1) and its binding site, the epidermal growth factor receptor (EGFR) (MR2), are efficacious against PC-3 and LNCaP prostate tumors...
  18. ncbi Human plasmacytoid dendritic cells express receptors for anaphylatoxins C3a and C5a and are chemoattracted to C3a and C5a
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical School, Hannover, Germany
    J Invest Dermatol 126:2422-9. 2006
    The presence of plasmacytoid dendritic cells (pDC) was recently demonstrated in lesions of inflammatory skin diseases...
  19. pmc Overproduction of threonine aldolase circumvents the biosynthetic role of pyruvate decarboxylase in glucose-limited chemostat cultures of Saccharomyces cerevisiae
    Antonius J A van Maris
    Kluyver Laboratory of Biotechnology, Delft University of Technology, The Netherlands
    Appl Environ Microbiol 69:2094-9. 2003
    Pyruvate decarboxylase-negative (Pdc(-)) mutants of Saccharomyces cerevisiae require small amounts of ethanol or acetate to sustain aerobic, glucose-limited growth...
  20. ncbi Systemic administration of anti-urokinase plasminogen activator receptor monoclonal antibodies induces hepatic fibrin deposition in tissue-type plasminogen activator deficient mice
    A Jogi
    Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark
    J Thromb Haemost 5:1936-44. 2007
    ..We have recently generated an inhibitory monoclonal antibody (mAb) against mouse u-PAR (mR1) by immunization of u-PAR-deficient mice.
  21. pmc Characterization of a lipoyl domain-independent B-cell autoepitope on the human branched-chain acyltransferase in primary biliary cirrhosis and overlap syndrome with autoimmune hepatitis
    Antal Csepregi
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Street 1, 30625 Hannover, Germany
    Clin Dev Immunol 10:173-81. 2003
    Antimitochondrial antibodies (AMA) which recognize pyruvate acetyltransferase (PDC-E2) represent a highly diagnostic feature of primary biliary cirrhosis (PBC)...
  22. doi Beyond Guam: the cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases
    Walter G Bradley
    Department of Neurology, Miller School of Medicine, University of Miami, 1120 NW 14 Street, Miami, FL 33136, USA
    Amyotroph Lateral Scler 10:7-20. 2009
    ..Research on Guam suggested that ALS, Parkinson's disease and dementia (the ALS/PDC complex) was due to a neurotoxic non-protein amino acid, beta-methylamino-L-alanine (BMAA), in the seeds of the ..
  23. pmc Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction
    James A Timmons
    Department of Physiology and Pharmacology, Berzelius väg 13, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Physiol 561:851-9. 2004
    We previously established that activation of the pyruvate dehydrogenase complex (PDC) using dichloroacetate (DCA) reduced the reliance on substrate-level phosphorylation (SLP) at the onset of exercise, with normal and reduced blood flow...
  24. ncbi [Quantitation of antigen specific T lymphocytes in peripheral blood of patients with primary biliary cirrhosis using tetramer technology]
    Hai Ying Liu
    Clinical Laboratory, General Hospital of Guangzhou, Guangzhou 510010, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22:78-81. 2006
    ..To quantitate antigen specific T lymphocytes in peripheral blood from patients with primary biliary cirrhosis(PBC) and study the role of antigen specific T lymphocytes in the development of PBC...
  25. ncbi A study on the B cell activity in protein deficient rats exposed to methyl isocyanate vapour
    A K Saxena
    Immunobiology Lab, Industrial Toxicology Research Centre, Lucknow, India
    Immunopharmacol Immunotoxicol 13:413-24. 1991
    ..01) in the protein deficient diet fed control (PDC) ones...
  26. ncbi Breakdown of tolerance to pyruvate dehydrogenase complex in experimental autoimmune cholangitis: a mouse model of primary biliary cirrhosis
    D E Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, UK
    Hepatology 30:65-70. 1999
    ..is characterized by autoreactive responses to a highly conserved self-antigen, pyruvate dehydrogenase complex (PDC)...
  27. ncbi Preventive dental care for young, Medicaid-insured children in Washington state
    Charlotte Lewis
    Division of General Pediatrics, Department of Pediatrics, Child Health Institute, School of Public Health, University of Washington, Seattle, Washington 98195, USA
    Pediatrics 124:e120-7. 2009
    Children from low-income families face barriers to preventive dental care (PDC) and are disproportionately affected by dental caries...
  28. ncbi Ca2+ -independent effects of spermine on pyruvate dehydrogenase complex activity in energized rat liver mitochondria incubated in the absence of exogenous Ca2+ and Mg2+
    E Pezzato
    Dipartimento di Chimica Biologica, Università di Padova e Istituto di Neuroscienze, CNR, Viale G Colombo 3, 35121 Padova, Italy
    Amino Acids 36:449-56. 2009
    ..of endogenous Ca(2+), the polyamine spermine is able to stimulate the activity of pyruvate dehydrogenase complex (PDC) of energized rat liver mitochondria (RLM)...
  29. ncbi Site-specific phosphorylation of phosducin in intact retina. Dynamics of phosphorylation and effects on G protein beta gamma dimer binding
    Bruce Y Lee
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
    J Biol Chem 279:54008-17. 2004
    Phosducin (Pdc) is a G protein beta gamma dimer (G beta gamma) binding protein, highly expressed in retinal photoreceptor and pineal cells, yet whose physiological role remains elusive...
  30. ncbi Investigation of a mechanism for accelerated breakdown of immune tolerance to the primary biliary cirrhosis-associated autoantigen, pyruvate dehydrogenase complex
    David E J Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, United Kingdom
    Lab Invest 82:211-9. 2002
    ..by autoreactive T- and B-cell responses to the highly conserved enzyme pyruvate dehydrogenase complex (PDC). In this study we have examined the breakdown of T-cell tolerance to self-PDC using a mouse model...
  31. pmc Double duty for a conserved glutamate in pyruvate decarboxylase: evidence of the participation in stereoelectronically controlled decarboxylation and in protonation of the nascent carbanion/enamine intermediate
    Danilo Meyer
    Albrecht von Haller Institute for Plant Sciences and Göttingen Center for Molecular Biosciences, Georg August University Gottingen, Ernst Caspari Haus, Justus von Liebig Weg 11, D 37077 Gottingen, Germany
    Biochemistry 49:8197-212. 2010
    Pyruvate decarboxylase (PDC) catalyzes the nonoxidative decarboxylation of pyruvate into acetaldehyde and carbon dioxide and requires thiamin diphosphate (ThDP) and a divalent cation as cofactors...
  32. doi Results of a retrospective database analysis of adherence to statin therapy and risk of nonfatal ischemic heart disease in daily clinical practice in Italy
    Giovanni Corrao
    Department of Statistics, Unit of Biostatistics and Epidemiology, University of Milano Bicocca, Milan, Italy
    Clin Ther 32:300-10. 2010
    ..However, inadequate adherence may reduce statins' protective effects...
  33. ncbi Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy
    D E Jones
    Centre for Liver Research, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Liver 20:351-6. 2000
    ..Although auto-reactive immune responses against pyruvate dehydrogenase complex (PDC) have been characterised in PBC, the lack of an animal model of the disease has limited study of the mechanisms of ..
  34. ncbi Bacterial motif DNA as an adjuvant for the breakdown of immune self-tolerance to pyruvate dehydrogenase complex
    David E J Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, England
    Hepatology 36:679-86. 2002
    ..the effects of CpG motif-containing oligodeoxynucleotides (ODN) on responses to pyruvate dehydrogenase complex (PDC, the autoantigen in PBC) in a murine model...
  35. ncbi Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate
    Nicholas E Simpson
    Department of Medicine, Division of Endocrinology and Metabolism, University of Florida, Gainesville, FL 32610, USA
    Mol Genet Metab 89:97-105. 2006
    The pyruvate dehydrogenase complex (PDC) is integral to metabolism and energetics. Congenital PDC deficiency leads to lactic acidosis, neurological degeneration and early death...
  36. ncbi Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
    Clin Gastroenterol Hepatol 6:1041-8. 2008
    ..in 95% of patients by autoantibody responses directed against the mitochondrial antigen pyruvate dehydrogenase complex (PDC). Although anti-PDC inhibits PDC function in vitro, mitochondrial function in vivo in PBC has not been examined.
  37. ncbi Identification of PDC-109-like protein(s) in buffalo seminal plasma
    Hiron M Harshan
    Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243122, India
    Anim Reprod Sci 115:306-11. 2009
    ..BSP-A1 and BSP-A2, the predominant proteins of the FN-2 family, are collectively termed as PDC-109...
  38. pmc Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation
    Nam Ho Jeoung
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Biochem J 397:417-25. 2006
    The PDC (pyruvate dehydrogenase complex) is strongly inhibited by phosphorylation during starvation to conserve substrates for gluconeogenesis...
  39. ncbi Covalent modification as a mechanism for the breakdown of immune tolerance to pyruvate dehydrogenase complex in the mouse
    Jeremy M Palmer
    Centre for Liver Research, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Hepatology 39:1583-92. 2004
    ..PBC) is characterized by the breakdown of normal immune self tolerance to pyruvate dehydrogenase complex (PDC)...
  40. pmc Apotopes and the biliary specificity of primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 49:871-9. 2009
    ..by antimitochondrial antibodies (AMAs), directed to the E2 component of the pyruvate dehydrogenase complex (PDC-E2)...
  41. ncbi Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway
    Hannah R Walden
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hepatology 48:1874-84. 2008
    Lipoylated enzymes such as the E2 component of pyruvate dehydrogenase complex (PDC-E2) are targets for autoreactive immune responses in primary biliary cirrhosis, with lipoic acid itself forming a component of the dominant auto-epitopes...
  42. doi The major protein of bovine seminal plasma, PDC-109, is a molecular chaperone
    Rajeshwer Singh Sankhala
    School of Chemistry, University of Hyderabad, Hyderabad 500046, India
    Biochemistry 49:3908-18. 2010
    The major protein of bovine seminal plasma, PDC-109, binds to choline phospholipids on the sperm plasma membrane and induces the efflux of cholesterol and choline phospholipids, which is an important step in sperm capacitation...
  43. ncbi Localization and regulation of plasma membrane Ca(2+)-ATPase in bovine spermatozoa
    Jörg Triphan
    Department of Anatomy and Cell Biology, Philipps University, Robert Koch Str 8, D 35037 Marburg, Germany
    Eur J Cell Biol 86:265-73. 2007
    ..We have recently shown that bovine sperm PMCA is stimulated by PDC-109, a secretory protein of bovine seminal vesicles...
  44. ncbi Characterization of the p-coumaric acid decarboxylase from Lactobacillus plantarum CECT 748(T)
    Hector Rodriguez
    Departamento de Microbiologia, Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
    J Agric Food Chem 56:3068-72. 2008
    ..The p-coumaric acid decarboxylase (PDC) from this strain has been overexpressed and purified...
  45. ncbi Regulation of pyruvate dehydrogenase complex activity in Ehrlich ascites carcinoma cells by Ca2+ and pyruvate
    G L Ermakov
    Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142292, Russia
    Biochemistry (Mosc) 64:318-25. 1999
    The dependence of pyruvate dehydrogenase complex (PDC) activity on [Ca2+] was determined in Ehrlich ascites carcinoma cells at different pyruvate concentrations...
  46. pmc Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity
    R Max Wynn
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9038, USA
    J Biol Chem 283:25305-15. 2008
    Human pyruvate dehydrogenase complex (PDC) is down-regulated by pyruvate dehydrogenase kinase (PDK) isoforms 1-4. PDK4 is overexpressed in skeletal muscle in type 2 diabetes, resulting in impaired glucose utilization...
  47. doi Circulating myeloid dendritic cells are increased in individuals with severe aplastic anemia
    Shao Zonghong
    Department of Hematology, General Hospital, Tianjin Medical University, 154 Anshandao, Tianjin 300052, Heping, People s Republic of China
    Int J Hematol 93:156-62. 2011
    ..of the study were to investigate the number of myeloid dendritic cells (mDC) and plasmacytoid dendritic cells (pDC) present in peripheral blood mononuclear cells (PBMC) from severe aplastic anemia (SAA) patients before and after ..
  48. pmc Type I interferon-dependent gene MxA in perinatal HIV-infected patients under antiretroviral therapy as marker for therapy failure and blood plasmacytoid dendritic cells depletion
    Raffaele Badolato
    Istituto di Medicina Molecolare Angelo Nocivelli, Department of Pediatrics, University of Brescia, Brescia 25123, Italy
    J Transl Med 6:49. 2008
    ..in controlling HIV infection we phenotypically and functionally analyzed circulating plasmacytoid dendritic cells (pDC), which are known to be the highest interferon-alpha producing cells, in 33 perinatally infected HIV+ patients ..
  49. ncbi Anti-CD25 mAb, anti-IL2 mAb, and IL2 block tolerance induction through anti-CD154 mAb and rapamycin in xenogeneic islet transplantation
    H Pan
    Department of General Surgery West China Hospital, Si Chuan University, Chengdu, Sichuan, China
    Transplant Proc 39:3452-4. 2007
    We have used anti-CD154 monoclonal antibody (mAb; MR1) and rapamycin (rapa) to induce tolerance to islet xenografts...
  50. ncbi Comparing adherence and persistence across 6 chronic medication classes
    Jason Yeaw
    IMS Health, 311 Arsenal St, Watertown, MA 02472, USA
    J Manag Care Pharm 15:728-40. 2009
    The National Quality Forum recently endorsed the proportion of days covered (PDC)-a measure of medication adherence-as an indicator of quality in drug therapy management.
  51. ncbi Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis
    Akira Kawano
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Immunol 179:3315-24. 2007
    Primary biliary cirrhosis is characterized by autoreactive T cells specific for the mitochondrial Ag PDC-E2(163-176)...
  52. ncbi Peripheral blood T-cell responses to pyruvate dehydrogenase complex in primary biliary cirrhosis: role of antigen-presenting dendritic cells
    S M Akbar
    Ehime University School of Medicine, Ehime, Japan, Teikyo University Mizonokuchi Hospital, Kanagawa, Japan
    Eur J Clin Invest 31:639-46. 2001
    ..biliary cirrhosis (PBC) are usually characterized by the presence of antibody to pyruvate dehydrogenase complex (PDC) in the sera and PDC-specific T cells in the liver...
  53. pmc Plasmacytoid dendritic cell dynamics tune interferon-alfa production in SIV-infected cynomolgus macaques
    Timothée Bruel
    Division of Immuno Virology, Institute of Emerging Diseases and Innovative Therapies, CEA, Fontenay aux Roses, France Unité Mixte de Recherche UMR E01, Universite Paris Sud, Orsay, France
    PLoS Pathog 10:e1003915. 2014
    ..However, acute IFN-I plasma concentrations rapidly decline thereafter. Plasmacytoid dendritic cells (pDC) are key players in this production but primary infection is associated with decreased responsiveness of pDC to TLR ..
  54. pmc Myofibrillogenesis regulator-1 overexpression is associated with poor prognosis of gastric cancer patients
    Jing Guo
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Gastrointestinal Surgery, Peking University Cancer Hospital, Beijing Cancer Hospital and Institute, Beijing 100142, China
    World J Gastroenterol 18:5434-41. 2012
    ..To investigate the expression of myofibrillogenesis regulator-1 (MR-1) in relation to clinicopathological parameters and postoperative survival in a group of Chinese patients with gastric cancer...
  55. doi Molecular recognition modes between adenine or adeniniun(1+) ion and binary M(II)(pdc) chelates (MCoZn; pdc=pyridine-2,6-dicarboxylate(2-) ion)
    María Del Pilar Brandi-Blanco
    Department of Inorganic Chemistry, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain Electronic address
    J Inorg Biochem 127:211-9. 2013
    Mixed ligand M(II)-complexes (MCoZn) with pyridine-2,6-dicarboxylate(2-) chelator (pdc) and adenine (Hade) have been synthesized and studied by X-ray diffraction and other spectral and thermal methods: [Cu(pdc)(H(N9)ade)(H2O)] (1), [Cu2(..
  56. ncbi Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells
    Miren Kerkmann
    Department of Internal Medicine, Division of Clinical Pharmacology, University of Munich, Munich, Germany
    J Immunol 170:4465-74. 2003
    ..CpG oligonucleotides (ODN) were used to study the regulation of type I IFN in human plasmacytoid dendritic cells (PDC): ODN 2216, a CpG-A ODN, known to induce high amounts of IFN-alpha in PDC, and ODN 2006, a CpG-B ODN, which is ..
  57. ncbi Collaborative action of NF-kappaB and p38 MAPK is involved in CpG DNA-induced IFN-alpha and chemokine production in human plasmacytoid dendritic cells
    Youko Osawa
    Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, 23 3 Matsuoka Shimoaizuki, Eiheiji cho, Yoshida gun, Fukui 910 1193, Japan
    J Immunol 177:4841-52. 2006
    CpG DNA induces plasmacytoid dendritic cells (pDC) to produce type I IFN and chemokines. However, it has not been fully elucidated how the TLR9 signaling pathway is linked to these gene expressions...
  58. ncbi Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its Lactobacillus mimic
    Dimitrios Petrou Bogdanos
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Hepatology 42:458-65. 2005
    ..hallmark of primary biliary cirrhosis (PBC) is the presence of pyruvate dehydrogenase complex E2 subunit (PDC-E2) antimitochondrial antibodies (AMAs)...
  59. pmc Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis
    Hiroto Kita
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, California 95616, USA
    J Clin Invest 109:1231-40. 2002
    ..in the liver that are specific for peptides encoded by the E2 components of the pyruvate dehydrogenase complexes (PDC-E2)...
  60. ncbi Contrasting effects of submergence in light and dark on pyruvate decarboxylase activity in roots of rice lines differing in submergence tolerance
    Bijayalaxmi Mohanty
    Department of Biological Sciences, National University of Singapore, Science Drive 4, Singapore 117543, Republic of Singapore
    Ann Bot 91:291-300. 2003
    ..In all lines, activity of pyruvate decarboxylase (PDC), extracted from the apical 3-5 cm of root axes, decreased by 46-96 % and 38-76 %, respectively, during 5 or 10 d ..
  61. ncbi Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neurons
    Toshiyuki Himi
    Section of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Neurosci Res 71:679-88. 2003
    ..We sought evidence that L-trans-pyrrolidine-2,4-dicarboxylate (PDC) enhances glutamate-induced neuronal damage not only via the N-methyl-D-aspartate (NMDA) receptor mediated pathway, ..
  62. ncbi Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice
    Teresa A Hopkins
    Departments of Pharmacology and Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Am J Physiol Heart Circ Physiol 285:H270-6. 2003
    The pyruvate dehydrogenase enzyme complex (PDC) is rate limiting for glucose oxidation in the heart...
  63. pmc Cloning and characterization of the Zymobacter palmae pyruvate decarboxylase gene (pdc) and comparison to bacterial homologues
    Krishnan Chandra Raj
    Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida 32611 0700, USA
    Appl Environ Microbiol 68:2869-76. 2002
    Pyruvate decarboxylase (PDC) is the key enzyme in all homo-ethanol fermentations. Although widely distributed among plants, yeasts, and fungi, PDC is absent in animals and rare in bacteria (established for only three organisms)...
  64. ncbi Longitudinal changes of peritoneal function calculated by personal dialysis capacity in a patient after long-term continuous ambulatory peritoneal dialysis
    Hidetomo Nakamoto
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Adv Perit Dial 19:97-102. 2003
    ..we investigated longitudinal changes in peritoneal function, as calculated by the personal dialysis capacity (PDC) test, after patient withdrawal from 17 years of continuous ambulatory peritoneal dialysis (CAPD)...
  65. ncbi Role of the isoprenyl pocket of the G protein beta gamma subunit complex in the binding of phosducin and phosducin-like protein
    Georgi L Lukov
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
    Biochemistry 43:5651-60. 2004
    Phosducin (Pdc) and phosducin-like protein (PhLP) regulate G protein-mediated signaling by binding to the betagamma subunit complex of heterotrimeric G proteins (Gbetagamma) and removing the dimer from cell membranes...
  66. ncbi Purification, characterization, cloning and expression of pyruvate decarboxylase from Torulopsis glabrata IFO005
    Qinhong Wang
    Center for Microbial Biotechnology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, P R China
    J Biochem 136:447-55. 2004
    ..production of pyruvate and optically active alpha-hydroxy ketones by Torulopsis glabrata, pyruvate decarboxylase (PDC, EC 4.1.1...
  67. ncbi Relationship between peripheral blood dendritic cells and cytokines involved in the pathogenesis of systemic lupus erythematosus
    Ewa Robak
    Department of Dermatology and Venerology, Medical University of Łódź, ul Krzemieniecka 5, 94 017 Łódź, Poland
    Eur Cytokine Netw 15:222-30. 2004
    ..In this study we investigated the relationship between the total number of DC (tDC), and their plasmacytoid (pDC) and myeloid (mDC) subpopulations, with serum concentrations of interferons (IFN-alpha and IFN-gamma) and selected ..
  68. ncbi A key role for autoreactive B cells in the breakdown of T-cell tolerance to pyruvate dehydrogenase complex in the mouse
    Amanda J Robe
    Liver Research Group, University of Newcastle, Newcastle upon Tyne, UK
    Hepatology 41:1106-12. 2005
    ..liver disease primary biliary cirrhosis is breakdown of T-cell self-tolerance to pyruvate dehydrogenase complex (PDC). The mechanism resulting in this breakdown of tolerance remains unclear...
  69. ncbi A flow cytometric method for determination of absolute counts of myeloid precursor dendritic cells in peripheral blood
    Ling Ma
    Laboratory for Experimental Hematology, University of Leuven, University Hospital Leuven, Leuven, Belgium
    J Immunol Methods 285:215-21. 2004
    ..They have a typical immunophenotypic profile, yet, they cannot be identified by pDC-specific immunophenotypic markers and therefore, their accurate and absolute enumeration poses a challenge...
  70. pmc Vehicle exhaust gas clearance by low temperature plasma-driven nano-titanium dioxide film prepared by radiofrequency magnetron sputtering
    Shuang Yu
    Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
    PLoS ONE 8:e59974. 2013
    A novel plasma-driven catalysis (PDC) reactor with special structure was proposed to remove vehicle exhaust gas...
  71. doi Antiviral vaccines license T cell responses by suppressing granzyme B levels in human plasmacytoid dendritic cells
    Dorit Fabricius
    Department of Pediatrics, University Medical Center Ulm, 89075 Ulm, Germany
    J Immunol 191:1144-53. 2013
    Human plasmacytoid dendritic cells (pDC) are important modulators of adaptive T cell responses during viral infections...
  72. ncbi Myofibrillogenesis regulator 1 gene (MR-1) mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia
    Anne Hempelmann
    Gene Mapping Center, Max Delbruck Center for Molecular Medicine, Department of Neurology, Charite University Medicine, Berlin, Germany, and Department of Neurology, The Royal Hospital, Muscat, Oman
    Neurosci Lett 402:118-20. 2006
    Two recurrent missense mutations (c.20C>T: A7V; c.26C>T: A9V) in the gene encoding the myofibrillogenesis regulator 1 (MR-1) have been shown to cause autosomal dominant paroxysmal nonkinesigenic dyskinesia (PNKD) in 13 families of ..
  73. pmc Chronic immune activation in HIV-1 infection contributes to reduced interferon alpha production via enhanced CD40:CD40 ligand interaction
    Norbert Donhauser
    Institute of Clinical and Molecular Virology, German National Reference Centre for Retroviruses, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 7:e33925. 2012
    ..IFN-)alpha production is observed in HIV-1 infection, the response of circulating plasmacytoid dendritic cells (PDC) to Toll-like receptor ligand stimulation is substantially impaired...
  74. doi Top-down mass spectrometry reveals new sequence variants of the major bovine seminal plasma protein PDC-109
    Mikko Laitaoja
    Department of Chemistry, University of Eastern Finland, FI 80101, Joensuu, Finland
    J Mass Spectrom 47:853-9. 2012
    The major protein of bovine seminal plasma, PDC-109, is a 109-residue polypeptide that exists as a polydisperse aggregate under native conditions...
  75. pmc Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells
    Zhiwei Yin
    Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 189:2735-45. 2012
    Plasmacytoid dendritic cells (pDC) are rare cells found in peripheral blood and lymphoid tissues...
  76. pmc MAIT cell recognition of MR1 on bacterially infected and uninfected cells
    Mary H Young
    Integrated Department of Immunology, National Jewish Health and University of Colorado School of Medicine, Denver, Colorado, United States of America
    PLoS ONE 8:e53789. 2013
    ..population of T cells that express a semi-invariant αβ TCR and are restricted by the MHC class I-related molecule MR1. MAIT cells recognize uncharacterized ligand(s) presented by MR1 through the cognate interaction between their TCR ..
  77. ncbi Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion
    M C Sugden
    Department of Diabetes and Metabolic Medicine, Division of General and Developmental Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London, U K
    Diabetes 50:2729-36. 2001
    The pyruvate dehydrogenase complex (PDC) has a pivotal role in islet metabolism. The pyruvate dehydrogenase kinases (PDK1-4) regulate glucose oxidation through inhibitory phosphorylation of PDC...
  78. ncbi Mycoplasma antigens as a possible trigger for the induction of antimitochondrial antibodies in primary biliary cirrhosis
    Christoph P Berg
    Department of Internal Medicine I, Medical Clinic, Eberhard Karls University of Tubingen, Tubingen, Germany
    Liver Int 29:797-809. 2009
    In primary biliary cirrhosis (PBC), autoreactivity mainly targets members of the pyruvate dehydrogenase complex (PDC)...
  79. ncbi Plasmacytoid DC promote priming of autoimmune Th17 cells and EAE
    Magnus Isaksson
    Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden
    Eur J Immunol 39:2925-35. 2009
    ..To investigate the role of plasmacytoid DC (pDC) in the initiation of autoimmune Th17- and Th1-cell responses and EAE, we depleted pDC with anti-pDC Ag-1 (anti-..
  80. ncbi Regulation of alcoholic fermentation in coleoptiles of two rice cultivars differing in tolerance to anoxia
    J Gibbs
    Faculty of Agriculture Plant Sciences, University of Western Australia, Nedlands, Australia
    J Exp Bot 51:785-96. 2000
    ..ATP-dependent phosphofructokinase (PFK), pyrophosphate-dependent phosphofructokinase (PFP), pyruvate decarboxylase (PDC), and alcohol dehydrogenase (ADH)...
  81. doi Extended causal modeling to assess Partial Directed Coherence in multiple time series with significant instantaneous interactions
    Luca Faes
    Lab Biosegnali, Department of Physics and BIOtech, University of Trento, Via delle Regole 101, 38123, Mattarello, Trento, Italy
    Biol Cybern 103:387-400. 2010
    The Partial Directed Coherence (PDC) and its generalized formulation (gPDC) are popular tools for investigating, in the frequency domain, the concept of Granger causality among multivariate (MV) time series...
  82. doi Malposition of unerupted mandibular second premolar in children with palatally displaced canines
    Miri Shalish
    Department of Orthodontics, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel
    Angle Orthod 79:796-9. 2009
    ..of unerupted mandibular premolar (MnP2) is significantly greater in children with palatally displaced canines (PDC) than in those in a control sample; and (2) delayed tooth formation is significantly more frequent in children with ..
  83. pmc Role for plasmacytoid dendritic cells in the immune control of recurrent human herpes simplex virus infection
    Heather Donaghy
    Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
    J Virol 83:1952-61. 2009
    Plasmacytoid dendritic cells (pDC) are an important component of the innate immune response, producing large amounts of alpha interferon in response to viral stimulation in vitro...
  84. pmc Rapid influx and death of plasmacytoid dendritic cells in lymph nodes mediate depletion in acute simian immunodeficiency virus infection
    Kevin N Brown
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS Pathog 5:e1000413. 2009
    Plasmacytoid dendritic cells (pDC) are essential innate immune system cells that are lost from the circulation in human immunodeficiency virus (HIV)-infected individuals associated with CD4(+) T cell decline and disease progression...
  85. doi 31P NMR and AFM studies on the destabilization of cell and model membranes by the major bovine seminal plasma protein, PDC-109
    Rajani S Damai
    School of Chemistry, University of Hyderabad, Hyderabad 500 046, India
    IUBMB Life 62:841-51. 2010
    The effect of PDC-109 binding to dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylglycerol (DPPG) multilamellar vesicles (MLVs) and supported membranes was investigated by (31)P NMR spectroscopy and atomic force ..
  86. ncbi Plasmacytoid dendritic cells are dispensable during primary influenza virus infection
    Amaya I Wolf
    Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 182:871-9. 2009
    Plasmacytoid dendritic cells (pDC) are thought to be pivotal in the first line of defense against viral infections...
  87. pmc Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex
    Chad A Brautigam
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Biol Chem 284:13086-98. 2009
    The human pyruvate dehydrogenase complex (PDC) is a 9.5-megadalton catalytic machine that employs three catalytic components, i.e...
  88. pmc NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation
    Antonino Castellaneta
    Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 183:6922-32. 2009
    ..Following MDP stimulation in vivo, liver pDC, but not mDC, up-regulated expression of IFN regulatory factor 4 (IRF-4), a negative regulator of TLR signaling, ..
  89. ncbi Damage and repair of nerve cell DNA in toxic stress
    G E Kisby
    Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Drug Metab Rev 31:589-618. 1999
    It is generally agreed that ALS/PDC is triggered by a disappearing environmental factor peculiar to the lifestyle of people of the western Pacific (i.e., Guam, Irian Jaya, Indonesia, and the Kii Peninsula of Japan)...
  90. ncbi Single dose parenteral hyposensitization to poison ivy urushiol in guinea pigs
    L A Walker
    Research Institute of Pharmaceutical Sciences, University of Mississippi, University 38677, USA
    Immunopharmacol Immunotoxicol 17:565-76. 1995
    ..three different analogs of poison ivy urushiol were studied: 1) a mixture of pentadecyl and heptadecyl catechols (PDC/HDC), the saturated side chain analog of the natural urushiol mixture; 2) a mixture of the diacetate esters of PDC ..
  91. doi ALS-parkinsonism-dementia complex of Kii and other related diseases in Japan
    Ryuji Kaji
    Department of Neurology, Tokushima University Hospital, Japan
    Parkinsonism Relat Disord 18:S190-1. 2012
    The ALS/parkinsonism-dementia complex (PDC) of Kii is an endemic disease with a diverse phenotypic expression characteristic of classical ALS, parkinsonism and dementia...
  92. pmc Plasmacytoid dendritic cells protect against atherosclerosis by tuning T-cell proliferation and activity
    Isabelle T M N Daissormont
    Department of Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    Circ Res 109:1387-95. 2011
    Unlike conventional dendritic cells, plasmacytoid DCs (PDC) are poor in antigen presentation and critical for type I interferon response...
  93. pmc Efficient sensing of avian influenza viruses by porcine plasmacytoid dendritic cells
    Michael Bel
    Institute of Virology and Immunoprophylaxis, Mittelhausern, Switzerland
    Viruses 3:312-30. 2011
    ..Among the cells involved in the cytokine storm, plasmacytoid dendritic cells (pDC) could play an important role considering their unique capacity to secrete massive amounts of type I interferon (..
  94. ncbi Quantitative and functional alterations of plasmacytoid dendritic cells contribute to immune tolerance in ovarian cancer
    Sana Intidhar Labidi-Galy
    Departments of Medical Oncology, Centre de Recherche en Cancérologie de Lyon, Centre Leon Berard, Lyon, France
    Cancer Res 71:5423-34. 2011
    ..In this study, we investigated the contribution of plasmacytoid dendritic cells (pDC) in the establishment of immune tolerance in a cohort of 44 ovarian cancer patients...
  95. doi Identification of a lineage negative cell population in bovine peripheral blood with the ability to mount a strong type I interferon response
    Amanda Gibson
    The Royal Veterinary College, North Mymms, Hatfield, Hertfordshire, UK
    Dev Comp Immunol 36:332-41. 2012
    ..dendritic cells, or natural interferon-producing cells (NIPC), also referred to as plasmacytoid dendritic cells (pDC) constitute a small population of leukocytes secreting high levels of type I interferon (IFNα/β) in response to ..
  96. pmc Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity
    Lisa K Ryan
    The Public Health Research Institute and Department of Medicine, Division of Pulmonary and Critical Care Medicine, New Jersey Medical School, Newark, NJ 07103, USA
    J Leukoc Biol 90:343-56. 2011
    ..constitutively expressed in most cells in spite of cytokine or LPS stimulation; however, its presence in human PDC suggests it plays a role in viral host defense...
  97. pmc Hepatitis B virus lacks immune activating capacity, but actively inhibits plasmacytoid dendritic cell function
    Andrea M Woltman
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 6:e15324. 2011
    ..Activation of plasmacytoid dendritic cells (pDC) leading to IFNα production is important for effective anti-viral immunity...
  98. ncbi Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia
    Purnima Desai Sundar
    Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 16:295-306. 2007
    Unusual forms of amyotrophic lateral sclerosis (ALS-G), Parkinsonism dementia complex (PDC-G) and Guam dementia (GD) are found in Chamorros, the indigenous people of Guam...
  99. doi Technical advance: Generation of human pDC equivalents from primary monocytes using Flt3-L and their functional validation under hypoxia
    Divya Sekar
    Institute of Biochemistry I ZAFES, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Leukoc Biol 88:413-24. 2010
    ..mDC are efficient in antigen presentation, whereas pDC act as rheostats of the immune system...
  100. ncbi Biochemistry and autoimmune response to the 2-oxoacid dehydrogenase complexes in primary biliary cirrhosis
    M F Bassendine
    Department of Medicine, Medical School, University of Newcastle, Newcastle upon Tyne, U K
    Semin Liver Dis 17:49-60. 1997
    Pyruvate dehydrogenase complex (PDC), 2-oxo-glutarate dehydrogenase complex (OGDC), and the branched-chain 2-oxoacid dehydrogenase complex (BCOADC) constitute the 2-oxoacid dehydrogenase family of multienzyme complexes...
  101. pmc Inability of plasmacytoid dendritic cells to directly lyse HIV-infected autologous CD4+ T cells despite induction of tumor necrosis factor-related apoptosis-inducing ligand
    Jihed Chehimi
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Virol 84:2762-73. 2010
    The function of plasmacytoid dendritic cells (PDC) in chronic human immunodeficiency virus type 1 (HIV-1) infection remains controversial with regard to its potential for sustained alpha interferon (IFN-alpha) production and induction of ..

Research Grants117 found, 100 shown here

  1. DCTD Biopharmaceutical Development
    David Heimbrook; Fiscal Year: 2013
    ..A second trial in glioma is in the process of regulatory filing. A BDP product that was released before FY08 is MR1-1, an immunotoxin that targets glioma. The first two patients were treated with MR1-1 during FY08...
  2. Plasmacytoid Dendritic Cells in HIV Pathogenesis
    Patricia Fitzgerald-Bocarsly; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Plasmacytoid dendritic cells (pDC) are the most potent type I interferon (IFN)- producing cells in the body and are considered to be the "professional IFN producing cells"...
  3. Immune function and the progression to type 1 diabetes
    Mark A Atkinson; Fiscal Year: 2013
    ..defects in type 1 IFN biology, hyperactive IFN[unreadable]/[unreadable] responses and increased plasmacytoid DC (PDC)/IFN[unreadable]/[unreadable] production in the islet microenvironment play a critical role in T1D pathogenesis...
  4. Post-transcriptional regulation of the Dendritic Cell transcriptome
    Miriam Merad; Fiscal Year: 2013
    ..that are specialized in the cross-presentation of cell associated antigens to CD8+ T cells, and plasmacytoid DC (pDC), which help to establish an antiviral state through the rapid secretion of high amounts of interferon alpha...
  5. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert Harris; Fiscal Year: 2009
    ..The activity of the pyruvate dehydrogenase complex (PDC) is tightly regulated by phosphorylation by the PDKs...
  6. HCV, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2013
    ..We hypothesize that HCV-mediated signals play a role in HCV-induced alterations in dendritic cells (mDCI, mDC2, pDC) and contribute to the reduced T cell responses in HCV infection by induction of CD4+CD25+ regulatory T cells...
  7. T cell depletion in older HIV-infected patients by plasmacytoid dendritic cells
    VIRIAN DAVY SEREI; Fiscal Year: 2013
    ..Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons and are also known to express TRAIL during HIV infection...
  8. Targeting Plasmacytoid Dendritic Cells to Treat Human Myeloma
    Qing Yi; Fiscal Year: 2013
    ..However, several recent studies have also identified pDC as critical players in oral and airway tolerance...
  9. DCTD Biopharmaceutical Development
    LARRY ARTHUR; Fiscal Year: 2009
    ..A second trial in glioma is in the process of regulatory filing. A BDP product that was released before FY08 is MR1-1, an immunotoxin that targets glioma. The first two patients were treated with MR1-1 during FY08...
  10. DCTD Biopharmaceutical Development - Type 1 Diabetes RAID projects
    LARRY ARTHUR; Fiscal Year: 2009
    ..A second trial in glioma is in the process of regulatory filing. A BDP product that was released before FY08 is MR1-1, an immunotoxin that targets glioma. The first two patients were treated with MR1-1 during FY08...
  11. DCTD Biopharmaceutical Development
    LARRY ARTHUR; Fiscal Year: 2010
    ..A second trial in glioma is in the process of regulatory filing. A BDP product that was released before FY08 is MR1-1, an immunotoxin that targets glioma. The first two patients were treated with MR1-1 during FY08...
  12. DCTD Biopharmaceutical Development
    David Heimbrook; Fiscal Year: 2012
    ..A second trial in glioma is in the process of regulatory filing. A BDP product that was released before FY08 is MR1-1, an immunotoxin that targets glioma. The first two patients were treated with MR1-1 during FY08...
  13. DCTD Biopharmaceutical Development
    David Heimbrook; Fiscal Year: 2011
    ..A second trial in glioma is in the process of regulatory filing. A BDP product that was released before FY08 is MR1-1, an immunotoxin that targets glioma. The first two patients were treated with MR1-1 during FY08...
  14. HIV and Plasmacytoid dendritic cells in the thymus
    Christel Uittenbogaart; Fiscal Year: 2004
    Plasmacytoid dendritic cells (pDC) are lymphoid dendritic cells that express high levels of interleukin 3 (IL-3) receptor (CD 123) and produce type I interferons, cytokines with antiviral and immunoregulatory effects, pDC are present in ..
  15. HIV and Plasmacytoid dendritic cells in the thymus
    Christel Uittenbogaart; Fiscal Year: 2006
    Plasmacytoid dendritic cells (pDC) are lymphoid dendritic cells that express high levels of interleukin 3 (IL-3) receptor (CD 123) and produce type I interferons, cytokines with antiviral and immunoregulatory effects, pDC are present in ..
  16. HIV and Plasmacytoid dendritic cells in the thymus
    Christel Uittenbogaart; Fiscal Year: 2005
    Plasmacytoid dendritic cells (pDC) are lymphoid dendritic cells that express high levels of interleukin 3 (IL-3) receptor (CD 123) and produce type I interferons, cytokines with antiviral and immunoregulatory effects, pDC are present in ..
  17. HIV and Plasmacytoid dendritic cells in the thymus
    Christel Uittenbogaart; Fiscal Year: 2007
    Plasmacytoid dendritic cells (pDC) are lymphoid dendritic cells that express high levels of interleukin 3 (IL-3) receptor (CD 123) and produce type I interferons, cytokines with antiviral and immunoregulatory effects, pDC are present in ..
  18. HIV Dysregulation of Human Plasmacytoid Dendritic Cells
    MEAGAN O'BRIEN; Fiscal Year: 2013
    ..candidate's proposed research project centers on the idea that HIV dysregulates plasmacytoid dendritic cells (pDC) to activate deficient adaptive immune responses while stimulating persistent interferon-alpha (IFNa) production, ..
  19. Role of Peripheral Dendritic Cells in Central and Oral Tolerance
    Husein Hadeiba; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We have identified a potent tolerogenic plasmacytoid dendritic cell (pDC) population defined by expression of the chemokine receptor CCR9, and have shown that these CCR9+ pDCs not only induce ..
  20. Plasmacytoid Dendritic Cells in HIV Pathogenesis
    Patricia Fitzgerald Bocarsly; Fiscal Year: 2010
    Plasmacytoid dendritic cells (pDC) are the most potent type I interferon (IFN)- producing cells in the body and are considered to be the "professional IFN producing cells"...
  21. Plasmacytoid Dendritic Cells in HIV Pathogenesis
    Patricia Fitzgerald-Bocarsly; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Plasmacytoid dendritic cells (pDC) are the most potent type I interferon (IFN)- producing cells in the body and are considered to be the "professional IFN producing cells"...
  22. MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2013
    ..AMAs), which react specifically with the lipoyl domain of the pyruvate dehydrogenase complex E2 subunit (PDC-E2)...
  23. The Role of miRNA in Dendritic Cell Function
    GREGORY MULLOKANDOV; Fiscal Year: 2013
    ..Plasmacytoid DC (pDC) is a major subset of DCs and are one of the earliest defenses of the body against specific pathogens...
  24. Retrovirus Isolation from Primary Biliary Cirrhosis
    Andrew Mason; Fiscal Year: 2004
    ..of patients develop anti-mitochondrial antibodies (AMA) reactive to pyruvate dehydrogenase complex E2 component (PDC-E2), which is aberrantly expressed on cell surface of biliary epithelial cells of patients with PBC...
  25. Retrovirus Isolation from Primary Biliary Cirrhosis
    Andrew Mason; Fiscal Year: 2003
    ..of patients develop anti-mitochondrial antibodies (AMA) reactive to pyruvate dehydrogenase complex E2 component (PDC-E2), which is aberrantly expressed on cell surface of biliary epithelial cells of patients with PBC...
  26. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2013
    ..by breach of tolerance to the major mitochondrial autoantigen, the E2 component of pyruvate dehydrogenase (PDC-E2)...
  27. INBORN ERRORS OF METABOLISM IN CELL CULTURE
    DAVID CHUANG; Fiscal Year: 2009
    ..comprises the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), the pyruvate dehydrogenase complex (PDC) and the alpha-ketoglutarate dehydrogenase complex (KGDC)...
  28. INBORN ERRORS OF METABOLISM IN CELL CULTURE
    DAVID CHUANG; Fiscal Year: 2006
    ..comprises the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), the pyruvate dehydrogenase complex (PDC) and the alpha-ketoglutarate dehydrogenase complex (KGDC)...
  29. INBORN ERRORS OF METABOLISM IN CELL CULTURE
    DAVID CHUANG; Fiscal Year: 2007
    ..comprises the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), the pyruvate dehydrogenase complex (PDC) and the alpha-ketoglutarate dehydrogenase complex (KGDC)...
  30. INBORN ERRORS OF METABOLISM IN CELL CULTURE
    David T Chuang; Fiscal Year: 2010
    ..comprises the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), the pyruvate dehydrogenase complex (PDC) and the alpha-ketoglutarate dehydrogenase complex (KGDC)...
  31. INBORN ERRORS OF METABOLISM IN CELL CULTURE
    David T Chuang; Fiscal Year: 2010
    ..comprises the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), the pyruvate dehydrogenase complex (PDC) and the alpha-ketoglutarate dehydrogenase complex (KGDC)...
  32. REGULATION OF MAMMALIAN PYRUVATE DEHYDROGENASE
    THOMAS ROCHE; Fiscal Year: 2000
    DESCRIPTION (adapted from the applicant's abstract): The pyruvate dehydrogenase complex (PDC) functions at an important branch point for energy metabolism in regard to the utilization and storage of cellular fuels--carbohydrate and fat...
  33. HIV and Plasmacytoid dendritic cells in the thymus
    Christel Uittenbogaart; Fiscal Year: 2002
    Plasmacytoid dendritic cells (pDC) or natural interferon type I producing cells play an important role in linking innate and acquired immunity...
  34. Regulation of metabolic gene expression
    EDWARDS PARK; Fiscal Year: 2009
    ..The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate to acetyl-CoA...
  35. Regulation of metabolic gene expression
    Edwards A Park; Fiscal Year: 2010
    ..The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate to acetyl-CoA...
  36. Autophagy in Antiviral Immunity
    Akiko Iwasaki; Fiscal Year: 2010
    ..In professional viral sensors, the plasmacytoid dendritic cells (pDC), recognition of viruses occurs in the endosomes via Toll-like receptors (TLR) 7 and 9...
  37. REGULATION OF MAMMALIAN PYRUVATE DEHYDROGENASE
    THOMAS ROCHE; Fiscal Year: 2004
    The mammalian pyruvate dehydrogenase complex (PDC) connects glycolysis to oxidative metabolism and fatty acid synthesis with the irretrievable loss of glucose carbons...
  38. REGULATION OF MAMMALIAN PYRUVATE DEHYDROGENASE
    THOMAS ROCHE; Fiscal Year: 2001
    The mammalian pyruvate dehydrogenase complex (PDC) connects glycolysis to oxidative metabolism and fatty acid synthesis with the irretrievable loss of glucose carbons...
  39. REGULATION OF MAMMALIAN PYRUVATE DEHYDROGENASE
    THOMAS ROCHE; Fiscal Year: 2003
    The mammalian pyruvate dehydrogenase complex (PDC) connects glycolysis to oxidative metabolism and fatty acid synthesis with the irretrievable loss of glucose carbons...
  40. REGULATION OF MAMMALIAN PYRUVATE DEHYDROGENASE
    THOMAS ROCHE; Fiscal Year: 2002
    The mammalian pyruvate dehydrogenase complex (PDC) connects glycolysis to oxidative metabolism and fatty acid synthesis with the irretrievable loss of glucose carbons...
  41. REGULATION OF MAMMALIAN PYRUVATE DEHYDROGENASE
    THOMAS ROCHE; Fiscal Year: 2000
    The mammalian pyruvate dehydrogenase complex (PDC) connects glycolysis to oxidative metabolism and fatty acid synthesis with the irretrievable loss of glucose carbons...
  42. CHARACTERIZATION OF A NEW FAMILY OF PROTEIN KINASES
    KIRILL POPOV; Fiscal Year: 2009
    The reaction catalyzed by mitochondrial pyruvate dehydrogenase complex (PDC) links glycolysis and Citric Acid Cycle...
  43. CHARACTERIZATION OF A NEW FAMILY OF PROTEIN KINASES
    Kirill M Popov; Fiscal Year: 2010
    The reaction catalyzed by mitochondrial pyruvate dehydrogenase complex (PDC) links glycolysis and Citric Acid Cycle...
  44. 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASE
    JAMES STOOPS; Fiscal Year: 1999
    ..Mammalian pyruvate dehydrogenase complex (PDC) plays a critical role in regulating cellular fuel utilization in the heart and, therefore, studies of the ..
  45. INBORN ERRORS OF PYRUVATE METABOLISM
    Mulchand Patel; Fiscal Year: 1999
    The pyruvate dehydrogenase complex (PDC) plays a pivotal role in the metabolism of pyruvate for energy production and for biosynthetic processes...
  46. Plasmacytoid Dendritic Cells and Transplant Tolerance
    Angus Thomson; Fiscal Year: 2005
    Plasmacytoid' dendritic cells (pDC) can regulate human T cell responses in vitro, including induction of T regulatory (T reg) cells. This suggests a role for pDC in immunological tolerance...
  47. Plasmacytoid Dendritic Cells and Transplant Tolerance
    Angus Thomson; Fiscal Year: 2007
    Plasmacytoid' dendritic cells (pDC) can regulate human T cell responses in vitro, including induction of T regulatory (T reg) cells. This suggests a role for pDC in immunological tolerance...
  48. Plasmacytoid Dendritic Cells and Transplant Tolerance
    Angus Thomson; Fiscal Year: 2006
    Plasmacytoid' dendritic cells (pDC) can regulate human T cell responses in vitro, including induction of T regulatory (T reg) cells. This suggests a role for pDC in immunological tolerance...
  49. REGULATION OF PYRUVATE DEHYDROGENASE KINASE
    Robert Harris; Fiscal Year: 1999
    The activity of the pyruvate dehydrogenase complex (PDC) is regulated by interconversion of phosphorylated (inactive) and non-phosphorylated (active) forms of the complex...
  50. REGULATION OF PYRUVATE DEHYDROGENASE KINASE
    Robert Harris; Fiscal Year: 2003
    The activity of the pyruvate dehydrogenase complex (PDC) is regulated by interconversion of phosphorylated (inactive) and non-phosphorylated (active) forms of the complex...
  51. REGULATION OF MAMMALIAN DIHYDROLIPOAMIDE DEHYDROGENASE
    Mulchand Patel; Fiscal Year: 2001
    ..In eukaryotic pyruvate dehydrogenase complex (PDC), E3 binds to an E3-binding protein (E3BP)...
  52. REGULATION OF MAMMALIAN DIHYDROLIPOAMIDE DEHYDROGENASE
    Mulchand Patel; Fiscal Year: 2000
    ..In eukaryotic pyruvate dehydrogenase complex (PDC), E3 binds to an E3-binding protein (E3BP)...
  53. REGULATION OF MAMMALIAN DIHYDROLIPOAMIDE DEHYDROGENASE
    Mulchand Patel; Fiscal Year: 2000
    ..In eukaryotic pyruvate dehydrogenase complex (PDC), E3 binds to an E3-binding protein (E3BP)...
  54. REGULATION OF MAMMALIAN DIHYDROLIPOAMIDE DEHYDROGENASE
    Mulchand Patel; Fiscal Year: 1999
    ..In eukaryotic pyruvate dehydrogenase complex (PDC), E3 binds to an E3-binding protein (E3BP)...
  55. REGULATION OF MAMMALIAN DIHYDROLIPOAMIDE DEHYDROGENASE
    Mulchand Patel; Fiscal Year: 2002
    ..In eukaryotic pyruvate dehydrogenase complex (PDC), E3 binds to an E3-binding protein (E3BP)...
  56. REGULATION OF PYRUVATE DEHYDROGENASE KINASE
    Robert Harris; Fiscal Year: 2005
    ..of this study is to establish the importance of regulation of the activity of the pyruvate dehydrogenase complex (PDC) to glucose homeostasis in the well-fed state, fasting, and diabetes...
  57. REGULATION OF PYRUVATE DEHYDROGENASE KINASE
    Robert Harris; Fiscal Year: 2006
    ..of this study is to establish the importance of regulation of the activity of the pyruvate dehydrogenase complex (PDC) to glucose homeostasis in the well-fed state, fasting, and diabetes...
  58. REGULATION OF PYRUVATE DEHYDROGENASE KINASE
    Robert Harris; Fiscal Year: 2007
    ..of this study is to establish the importance of regulation of the activity of the pyruvate dehydrogenase complex (PDC) to glucose homeostasis in the well-fed state, fasting, and diabetes...
  59. REGULATION OF PYRUVATE DEHYDROGENASE KINASE
    Robert Harris; Fiscal Year: 2004
    ..of this study is to establish the importance of regulation of the activity of the pyruvate dehydrogenase complex (PDC) to glucose homeostasis in the well-fed state, fasting, and diabetes...
  60. 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASE
    JAMES STOOPS; Fiscal Year: 2002
    ..Mammalian pyruvate dehydrogenase complex (PDC) plays a critical role in regulating cellular fuel utilization in the heart and, therefore, studies of the ..
  61. 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASE
    JAMES STOOPS; Fiscal Year: 2000
    ..Mammalian pyruvate dehydrogenase complex (PDC) plays a critical role in regulating cellular fuel utilization in the heart and, therefore, studies of the ..
  62. 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASE
    JAMES STOOPS; Fiscal Year: 2001
    ..Mammalian pyruvate dehydrogenase complex (PDC) plays a critical role in regulating cellular fuel utilization in the heart and, therefore, studies of the ..
  63. VOLATILE ACID FORMATION IN PARASITIC HELMINTHS
    Richard Komuniecki; Fiscal Year: 2003
    ..novel anaerobic mitochondria present in the parasitic nematode, Ascaris suum: The pyruvate dehydrogenase complex (PDC) plays a key role in regulating these anaerobic mitochondrial pathways and its regulation and subunit composition ..
  64. VOLATILE ACID FORMATION IN PARASITIC HELMINTHS
    Richard Komuniecki; Fiscal Year: 2004
    ..novel anaerobic mitochondria present in the parasitic nematode, Ascaris suum: The pyruvate dehydrogenase complex (PDC) plays a key role in regulating these anaerobic mitochondrial pathways and its regulation and subunit composition ..
  65. The endosomal SLC15A4 proton-coupled histidine transporter in lupus
    Argyrios N Theofilopoulos; Fiscal Year: 2013
    ..Among the innate immune cells implicated in the pathogenesis of lupus is the plasmacytoid dendritic cell (pDC) which constitute a small (<1%), but distinct population of cells that is thought to be activated by nucleic ..
  66. VOLATILE ACID FORMATION IN PARASITIC HELMINTHS
    Richard Komuniecki; Fiscal Year: 2001
    ..novel anaerobic mitochondria present in the parasitic nematode, Ascaris suum: The pyruvate dehydrogenase complex (PDC) plays a key role in regulating these anaerobic mitochondrial pathways and its regulation and subunit composition ..
  67. VOLATILE ACID FORMATION IN PARASITIC HELMINTHS
    Richard Komuniecki; Fiscal Year: 2000
    ..novel anaerobic mitochondria present in the parasitic nematode, Ascaris suum: The pyruvate dehydrogenase complex (PDC) plays a key role in regulating these anaerobic mitochondrial pathways and its regulation and subunit composition ..
  68. VOLATILE ACID FORMATION IN PARASITIC HELMINTHS
    Richard Komuniecki; Fiscal Year: 2002
    ..novel anaerobic mitochondria present in the parasitic nematode, Ascaris suum: The pyruvate dehydrogenase complex (PDC) plays a key role in regulating these anaerobic mitochondrial pathways and its regulation and subunit composition ..
  69. Activation of Plasmacytoid Dendritic Cells (pDCs) to Induce Antitumor Activity
    Patrick Hwu; Fiscal Year: 2011
    ..In Project 2, further characterization of pDC interactions will be performed in a murine tumor model...
  70. Mechanisms of dysregulated immunity with aging.
    DANIEL ROBERT GOLDSTEIN; Fiscal Year: 2013
    ..by using murine models to determine 1) if exaggerated inflammatory responses by NKT cells coupled to defective pDC responses are critical for the generation of IL-17 anti-viral CD4+ T cells during systemic herpes viral infections ..
  71. Activation of Plasmacytoid Dendritic Cells (pDCs) to Induce Antitumor Activity
    Patrick Hwu; Fiscal Year: 2010
    ..In Project 2, further characterization of pDC interactions will be performed in a murine tumor model...
  72. Activation of Plasmacytoid Dendritic Cells (pDCs) to Induce Antitumor Activity
    Patrick Hwu; Fiscal Year: 2009
    ..In Project 2, further characterization of pDC interactions will be performed in a murine tumor model...
  73. Activation of Plasmacytoid Dendritic Cells (pDCs) to Induce Antitumor Activity
    Patrick Hwu; Fiscal Year: 2010
    ..In Project 2, further characterization of pDC interactions will be performed in a murine tumor model...
  74. CHARACTERIZATION OF A NEW FAMILY OF PROTEIN KINASES
    KIRILL POPOV; Fiscal Year: 2000
    DESCRIPTION: (From the application abstract:) The mitochondrial pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate, the reaction that determines the metabolic fate of carbohydrates...
  75. CHARACTERIZATION OF A NEW FAMILY OF PROTEIN KINASES
    KIRILL POPOV; Fiscal Year: 2001
    DESCRIPTION: (From the application abstract:) The mitochondrial pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate, the reaction that determines the metabolic fate of carbohydrates...
  76. CHARACTERIZATION OF A NEW FAMILY OF PROTEIN KINASES
    KIRILL POPOV; Fiscal Year: 2003
    DESCRIPTION: (From the application abstract:) The mitochondrial pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate, the reaction that determines the metabolic fate of carbohydrates...
  77. CHARACTERIZATION OF A NEW FAMILY OF PROTEIN KINASES
    KIRILL POPOV; Fiscal Year: 2002
    DESCRIPTION: (From the application abstract:) The mitochondrial pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate, the reaction that determines the metabolic fate of carbohydrates...
  78. INBORN ERRORS OF THE PYRUVATE DEHYDROGENASE COMPLEX
    Isaiah Wexler; Fiscal Year: 1990
    The aim of the proposed project is to identify and analyze mutations responsible for pyruvate dehydrogenase complex (PDC) deficiency, an inherited disorder of energy metabolism which causes lactic acidosis and neurologic disability...
  79. Regulation of Energy Metabolism by PDP1 and PDP2
    Kirill M Popov; Fiscal Year: 2010
    ..understand the molecular mechanisms responsible for the regulation of mitochondrial pyruvate dehydrogenase complex (PDC)...
  80. Regulation of Energy Metabolism by PDP1 and PDP2
    KIRILL POPOV; Fiscal Year: 2009
    ..understand the molecular mechanisms responsible for the regulation of mitochondrial pyruvate dehydrogenase complex (PDC)...
  81. INBORN ERRORS OF PYRUVATE METABOLISM
    Mulchand Patel; Fiscal Year: 1991
    ..of this proposal are to investigate the mechanism of genetic defects of the human pyruvate dehydrogenase complex (PDC), a key enzyme of energy metabolism, and to improve understanding of the relationship of normal structure and ..
  82. Regulation of Energy Metabolism by PDP1 and PDP2
    Kirill M Popov; Fiscal Year: 2010
    ..understand the molecular mechanisms responsible for the regulation of mitochondrial pyruvate dehydrogenase complex (PDC)...
  83. Challenges in beta-Lactamase Mediated Resistance
    Robert A Bonomo; Fiscal Year: 2010
    ..pneumoniae and the AmpC of P. aeruginosa, PDC-3...
  84. MEASUREMENTS AND METHODS
    Vincent Mor; Fiscal Year: 2007
    ..The PDC Core unifies the LTC P01, will serve all four proposed research projects in the first three years of the program ..
  85. GENETIC ANALYSIS OF PAROXYSMAL DYSTONIC CHOREOATHETOSIS
    John Fink; Fiscal Year: 1999
    ..The principal investigator proposes to study paroxysmal dystonic choreoathetosis (PDC), an inherited disorder characterized by attacks of involuntary movements that occur spontaneously at rest and ..
  86. GENETIC ANALYSIS OF PAROXYSMAL DYSTONIC CHOREOATHETOSIS
    John Fink; Fiscal Year: 2000
    ..The principal investigator proposes to study paroxysmal dystonic choreoathetosis (PDC), an inherited disorder characterized by attacks of involuntary movements that occur spontaneously at rest and ..
  87. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2009
    ..occurs due to the loss of CD4 T cells and type I interferon (type-I-IFN) producing plasmacytoid dendritic cell (pDC). These infections contribute greatly to morbidity and mortality...
  88. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2010
    ..occurs due to the loss of CD4 T cells and type I interferon (type-I-IFN) producing plasmacytoid dendritic cell (pDC). These infections contribute greatly to morbidity and mortality...
  89. HIV-1 Replication and Pathogenesis in vivo
    Lishan Su; Fiscal Year: 2009
    forARRA years 1-2funding The goals of this project are to define how HIV-1 interacts with pDC and to elucidate the role of pDC cells in HIV-1 replication and pathogenesis...
  90. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    Lisa Ryan; Fiscal Year: 2007
    ..One type of DC, the plasmacytoid DC (PDC) is important in innate immune function through the production of interferon-? (IFN) induced by enveloped viruses ..
  91. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    Lisa Ryan; Fiscal Year: 2007
    ..One type of DC, the plasmacytoid DC (PDC) is important in innate immune function through the production of interferon-? (IFN) induced by enveloped viruses ..
  92. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..One type of DC, the plasmacytoid DC (PDC) is important in innate immune function through the production of interferon-? (IFN) induced by enveloped viruses ..
  93. Targeting pDCs for the Generation of Effective Anti-HCV CD8+ T-Cell Immunity
    John Connolly; Fiscal Year: 2009
    ..Furthermore we have demonstrated that targeting antigens to this compartment in an activated pDC is sufficient to initiate potent CD8+ T-cell responses...
  94. Recognition of Mtb-Infected Cells by Non-Classically Restritcted CD8+ T Cells
    David M Lewinsohn; Fiscal Year: 2011
    ..of differentiation 8+ (CD8+) T cells restricted by the non-classical Human Leukocyte Antigen 1b (HLA-Ib) molecule MR1. This molecule has not previously been shown to present pathogen associated antigens...
  95. Genetic, Viral and Immunlogic Studies in New Zealand Mice
    Syamal K Datta; Fiscal Year: 2010
    ..This therapy in SNF1 mice with spontaneous SLE, generates tolerogenic plasmacytoid dendritic cells (pDC) that cause expansion of autoantigen-specific Treg cells and contraction of autoimmune and inflammatory Th1 and ..
  96. Genetic, Viral and Immunlogic Studies in New Zealand Mice
    SYAMAL DATTA; Fiscal Year: 2009
    ..This therapy in SNF1 mice with spontaneous SLE, generates tolerogenic plasmacytoid dendritic cells (pDC) that cause expansion of autoantigen-specific Treg cells and contraction of autoimmune and inflammatory Th1 and ..