Genomes and Genes
Gene Symbol: PNKD
Description: paroxysmal nonkinesigenic dyskinesia
Alias: BRP17, DYT8, FKSG19, FPD1, KIPP1184, MR-1, MR1, PDC, PKND1, TAHCCP2, brain protein 17, myofibrillogenesis regulator 1, trans-activated by hepatitis C virus core protein 2
Publications144 found, 100 shown here
- Presence of alanine-to-valine substitutions in myofibrillogenesis regulator 1 in paroxysmal nonkinesigenic dyskinesia: confirmation in 2 kindredsDong Hui Chen
Department of Neurology, University of Washington, Seattle, 98195 7720, USA
Arch Neurol 62:597-600. 2005..An autosomal dominant form of this disorder was mapped to chromosome 2q33-36, and different missense mutations in exon 1 of the myofibrillogenesis regulator 1 (MR1) gene were identified recently in 2 kindreds.
- The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathwayHsien Yang Lee
Department of Neurology, UCSF, San Francisco, CA, USA
Hum Mol Genet 13:3161-70. 2004..We report mutations in the myofibrillogenesis regulator 1 (MR-1) gene causing PNKD in 50 individuals from eight families...
- Paroxysmal non-kinesigenic dyskinesia is caused by mutations of the MR-1 mitochondrial targeting sequenceDaniele Ghezzi
Pierfranco and Luisa Mariani Center for the Study of Children s Mitochondrial Disorders, National Neurological Institute Carlo Besta, Milan, Italy
Hum Mol Genet 18:1058-64. 2009Paroxysmal non-kinesigenic dyskinesia (PNKD) is an autosomal-dominant movement disorder characterized by attacks of dystonia, chorea and athetosis...
- Characterization of MR-1, a novel myofibrillogenesis regulator in human muscleTian Bo Li
Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050, China
Acta Biochim Biophys Sin (Shanghai) 36:412-8. 2004..These studies suggested that MR-1 might play a regulatory role in the muscle cell and it was worth investigating further...
- Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activityS Ravindran
Department of Biochemistry, Kansas State University, Manhattan 66506, USA
J Biol Chem 271:653-62. 1996To conserve carbohydrate reserves, the reaction of the pyruvate dehydrogenase complex (PDC) must be down-regulated when the citric acid cycle is provided sufficient acetyl-CoA...
- Parkinsonism, dementia and vertical gaze palsy in a Guamanian with atypical neuroglial degenerationK Oyanagi
Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
Acta Neuropathol 99:73-80. 2000..The clinical diagnosis was parkinsonism-dementia complex (PDC) with vertical gaze palsy...
- Combination chemotherapy employing bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate tumorsMarvin Rubenstein
Division of Cellular Biology, Hektoen Institute for Medical Research, 2100 W Harrison Street, Chicago, IL 60612, USA
Med Oncol 24:372-8. 2007..we demonstrated that antisense oligonucleotides (oligos) against transforming growth factor-alpha (TGF-alpha [MR1]), its binding site the epidermal growth factor receptor (EGFR [MR2]), and the anti-apoptosis protein bcl-2 (MR4) ..
- Comparative study of the activity and kinetic properties of malate dehydrogenase and pyruvate decarboxylase from Candida albicans, Malassezia pachydermatis, and Saccharomyces cerevisiaeAdam Tylicki
Institute of Biology, University of Białystok, Swierkowa 20B, 15 950 Białystok, Poland
Can J Microbiol 54:734-41. 2008..We compare the properties of two enzymes, pyruvate decarboxylase (PDC) and malate dehydrogenase (MDH), from these species and from Saccharomyces cerevisiae cultivated under aerobic and ..
- Sera from patients with tuberculosis recognize the M2a-epitope (E2-subunit of pyruvate dehydrogenase) specific for primary biliary cirrhosisR Klein
Medizinische Klinik, University of Tubingen, Germany
Clin Exp Immunol 92:308-16. 1993..of the inner mitochondrial membrane consisting of six epitopes (E2 subunit of the pyruvate dehydrogenase complex (PDC), 70 kD; protein X of the PDC, 56 kD; alpha-ketoglutarate dehydrogenase complex, 52 kD; branched-chain alpha-..
- The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal musclePaul A Roberts
School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
J Physiol 545:297-304. 2002..of adrenaline infusion on the activation status of glycogen phosphorylase and the pyruvate dehydrogenase complex (PDC) and on the accumulation of glucose-6-phosphate (G-6-P) and acetylcarnitine in resting canine skeletal muscle...
- Genetic and biochemical characterization of a 2-pyrone-4, 6-dicarboxylic acid hydrolase involved in the protocatechuate 4, 5-cleavage pathway of Sphingomonas paucimobilis SYK-6E Masai
Department of Bioengineering, Nagaoka University of Technology, Nagaoka, Niigata 940 2188, Japan
J Bacteriol 181:55-62. 1999..Yamasaki. J. Bacteriol. 172:2704-2709, 1990), we found the ligI gene encoding 2-pyrone-4, 6-dicarboxylic acid (PDC) hydrolase...
- Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitisTom J Sims
Department of Oral Medicine, University of Washington, Seattle WA 98195, USA
J Clin Periodontol 29:551-62. 2002..decarboxylase autoantibody (GAD65 Ab) levels were significantly associated with periodontal pocket depth change (PDC) and 2. serum IgG titers to P...
- The role of residues glutamate-50 and phenylalanine-496 in Zymomonas mobilis pyruvate decarboxylaseJ M Candy
Department of Biochemistry, University of Queensland, Brisbane, Australia
Biochem J 315:745-51. 1996..thiamine diphosphate (ThDP) as an essential cofactor, and we have used one of these, pyruvate decarboxylase (PDC; EC 22.214.171.124) from Zymomonas mobilis, as a model for this group of enzymes...
- Dendritic cells--at the front-line of pathogen attackKenneth C McCullough
Institute of Virology and Immunoprophylaxis, Research Department, Sensemattstrasse 293, CH 3147 Mittelhäusern, Switzerland
Vet Immunol Immunopathol 128:7-15. 2009..played by dendritic cells (DCs), particularly the interaction between conventional DC (cDC) and plasmacytoid DC (pDC), together with other monocytic cells...
- Tau-positive fine granules in the cerebral white matter: a novel finding among the tauopathies exclusive to parkinsonism-dementia complex of GuamMineo Yamazaki
Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu shi, Tokyo, Japan
J Neuropathol Exp Neurol 64:839-46. 2005We examined the autopsied brains of cases of 6 types of tauopathy: parkinsonism-dementia complex of Guam (PDC), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), Pick disease, Alzheimer disease (AD), and myotonic ..
- [Lessons from Guam ALS/PDC study]Hirano Asao
Division of Neuropathology, Montefiore Medical Center, Bronx, New York 10467 2490, USA
Rinsho Shinkeigaku 47:717-21. 2007An extraordinarily high incidence of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) affecting the native population was discovered on the island of Guam a half century ago...
- Bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate tumorsMarvin Rubenstein
Division of Cellular Biology, Hektoen Institute of Medicine, 2100 W Harrison Street, Chicago, IL, 60612, USA
Med Oncol 24:189-96. 2007Antisense oligonucleotides (oligos) against transforming growth factor-alpha (TGF-alpha) (MR1) and its binding site, the epidermal growth factor receptor (EGFR) (MR2), are efficacious against PC-3 and LNCaP prostate tumors...
- Human plasmacytoid dendritic cells express receptors for anaphylatoxins C3a and C5a and are chemoattracted to C3a and C5aRalf Gutzmer
Department of Dermatology and Allergology, Hannover Medical School, Hannover, Germany
J Invest Dermatol 126:2422-9. 2006The presence of plasmacytoid dendritic cells (pDC) was recently demonstrated in lesions of inflammatory skin diseases...
- Overproduction of threonine aldolase circumvents the biosynthetic role of pyruvate decarboxylase in glucose-limited chemostat cultures of Saccharomyces cerevisiaeAntonius J A van Maris
Kluyver Laboratory of Biotechnology, Delft University of Technology, The Netherlands
Appl Environ Microbiol 69:2094-9. 2003Pyruvate decarboxylase-negative (Pdc(-)) mutants of Saccharomyces cerevisiae require small amounts of ethanol or acetate to sustain aerobic, glucose-limited growth...
- Systemic administration of anti-urokinase plasminogen activator receptor monoclonal antibodies induces hepatic fibrin deposition in tissue-type plasminogen activator deficient miceA Jogi
Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark
J Thromb Haemost 5:1936-44. 2007..We have recently generated an inhibitory monoclonal antibody (mAb) against mouse u-PAR (mR1) by immunization of u-PAR-deficient mice.
- Characterization of a lipoyl domain-independent B-cell autoepitope on the human branched-chain acyltransferase in primary biliary cirrhosis and overlap syndrome with autoimmune hepatitisAntal Csepregi
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Street 1, 30625 Hannover, Germany
Clin Dev Immunol 10:173-81. 2003Antimitochondrial antibodies (AMA) which recognize pyruvate acetyltransferase (PDC-E2) represent a highly diagnostic feature of primary biliary cirrhosis (PBC)...
- Beyond Guam: the cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseasesWalter G Bradley
Department of Neurology, Miller School of Medicine, University of Miami, 1120 NW 14 Street, Miami, FL 33136, USA
Amyotroph Lateral Scler 10:7-20. 2009..Research on Guam suggested that ALS, Parkinson's disease and dementia (the ALS/PDC complex) was due to a neurotoxic non-protein amino acid, beta-methylamino-L-alanine (BMAA), in the seeds of the ..
- Acetyl group availability influences phosphocreatine degradation even during intense muscle contractionJames A Timmons
Department of Physiology and Pharmacology, Berzelius väg 13, Karolinska Institutet, 171 77 Stockholm, Sweden
J Physiol 561:851-9. 2004We previously established that activation of the pyruvate dehydrogenase complex (PDC) using dichloroacetate (DCA) reduced the reliance on substrate-level phosphorylation (SLP) at the onset of exercise, with normal and reduced blood flow...
- [Quantitation of antigen specific T lymphocytes in peripheral blood of patients with primary biliary cirrhosis using tetramer technology]Hai Ying Liu
Clinical Laboratory, General Hospital of Guangzhou, Guangzhou 510010, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22:78-81. 2006..To quantitate antigen specific T lymphocytes in peripheral blood from patients with primary biliary cirrhosis(PBC) and study the role of antigen specific T lymphocytes in the development of PBC...
- A study on the B cell activity in protein deficient rats exposed to methyl isocyanate vapourA K Saxena
Immunobiology Lab, Industrial Toxicology Research Centre, Lucknow, India
Immunopharmacol Immunotoxicol 13:413-24. 1991..01) in the protein deficient diet fed control (PDC) ones...
- Breakdown of tolerance to pyruvate dehydrogenase complex in experimental autoimmune cholangitis: a mouse model of primary biliary cirrhosisD E Jones
Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, UK
Hepatology 30:65-70. 1999..is characterized by autoreactive responses to a highly conserved self-antigen, pyruvate dehydrogenase complex (PDC)...
- Preventive dental care for young, Medicaid-insured children in Washington stateCharlotte Lewis
Division of General Pediatrics, Department of Pediatrics, Child Health Institute, School of Public Health, University of Washington, Seattle, Washington 98195, USA
Pediatrics 124:e120-7. 2009Children from low-income families face barriers to preventive dental care (PDC) and are disproportionately affected by dental caries...
- Ca2+ -independent effects of spermine on pyruvate dehydrogenase complex activity in energized rat liver mitochondria incubated in the absence of exogenous Ca2+ and Mg2+E Pezzato
Dipartimento di Chimica Biologica, Università di Padova e Istituto di Neuroscienze, CNR, Viale G Colombo 3, 35121 Padova, Italy
Amino Acids 36:449-56. 2009..of endogenous Ca(2+), the polyamine spermine is able to stimulate the activity of pyruvate dehydrogenase complex (PDC) of energized rat liver mitochondria (RLM)...
- Site-specific phosphorylation of phosducin in intact retina. Dynamics of phosphorylation and effects on G protein beta gamma dimer bindingBruce Y Lee
Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
J Biol Chem 279:54008-17. 2004Phosducin (Pdc) is a G protein beta gamma dimer (G beta gamma) binding protein, highly expressed in retinal photoreceptor and pineal cells, yet whose physiological role remains elusive...
- Investigation of a mechanism for accelerated breakdown of immune tolerance to the primary biliary cirrhosis-associated autoantigen, pyruvate dehydrogenase complexDavid E J Jones
Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, United Kingdom
Lab Invest 82:211-9. 2002..by autoreactive T- and B-cell responses to the highly conserved enzyme pyruvate dehydrogenase complex (PDC). In this study we have examined the breakdown of T-cell tolerance to self-PDC using a mouse model...
- Double duty for a conserved glutamate in pyruvate decarboxylase: evidence of the participation in stereoelectronically controlled decarboxylation and in protonation of the nascent carbanion/enamine intermediate Danilo Meyer
Albrecht von Haller Institute for Plant Sciences and Göttingen Center for Molecular Biosciences, Georg August University Gottingen, Ernst Caspari Haus, Justus von Liebig Weg 11, D 37077 Gottingen, Germany
Biochemistry 49:8197-212. 2010Pyruvate decarboxylase (PDC) catalyzes the nonoxidative decarboxylation of pyruvate into acetaldehyde and carbon dioxide and requires thiamin diphosphate (ThDP) and a divalent cation as cofactors...
- Results of a retrospective database analysis of adherence to statin therapy and risk of nonfatal ischemic heart disease in daily clinical practice in ItalyGiovanni Corrao
Department of Statistics, Unit of Biostatistics and Epidemiology, University of Milano Bicocca, Milan, Italy
Clin Ther 32:300-10. 2010..However, inadequate adherence may reduce statins' protective effects...
- Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathyD E Jones
Centre for Liver Research, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
Liver 20:351-6. 2000..Although auto-reactive immune responses against pyruvate dehydrogenase complex (PDC) have been characterised in PBC, the lack of an animal model of the disease has limited study of the mechanisms of ..
- Bacterial motif DNA as an adjuvant for the breakdown of immune self-tolerance to pyruvate dehydrogenase complexDavid E J Jones
Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, England
Hepatology 36:679-86. 2002..the effects of CpG motif-containing oligodeoxynucleotides (ODN) on responses to pyruvate dehydrogenase complex (PDC, the autoantigen in PBC) in a murine model...
- Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetateNicholas E Simpson
Department of Medicine, Division of Endocrinology and Metabolism, University of Florida, Gainesville, FL 32610, USA
Mol Genet Metab 89:97-105. 2006The pyruvate dehydrogenase complex (PDC) is integral to metabolism and energetics. Congenital PDC deficiency leads to lactic acidosis, neurological degeneration and early death...
- Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesisKieren G Hollingsworth
Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
Clin Gastroenterol Hepatol 6:1041-8. 2008..in 95% of patients by autoantibody responses directed against the mitochondrial antigen pyruvate dehydrogenase complex (PDC). Although anti-PDC inhibits PDC function in vitro, mitochondrial function in vivo in PBC has not been examined.
- Identification of PDC-109-like protein(s) in buffalo seminal plasmaHiron M Harshan
Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243122, India
Anim Reprod Sci 115:306-11. 2009..BSP-A1 and BSP-A2, the predominant proteins of the FN-2 family, are collectively termed as PDC-109...
- Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvationNam Ho Jeoung
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
Biochem J 397:417-25. 2006The PDC (pyruvate dehydrogenase complex) is strongly inhibited by phosphorylation during starvation to conserve substrates for gluconeogenesis...
- Covalent modification as a mechanism for the breakdown of immune tolerance to pyruvate dehydrogenase complex in the mouseJeremy M Palmer
Centre for Liver Research, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
Hepatology 39:1583-92. 2004..PBC) is characterized by the breakdown of normal immune self tolerance to pyruvate dehydrogenase complex (PDC)...
- Apotopes and the biliary specificity of primary biliary cirrhosisAna Lleo
Division of Rheumatology, University of California at Davis, Davis, CA 95616, USA
Hepatology 49:871-9. 2009..by antimitochondrial antibodies (AMAs), directed to the E2 component of the pyruvate dehydrogenase complex (PDC-E2)...
- Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathwayHannah R Walden
Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
Hepatology 48:1874-84. 2008Lipoylated enzymes such as the E2 component of pyruvate dehydrogenase complex (PDC-E2) are targets for autoreactive immune responses in primary biliary cirrhosis, with lipoic acid itself forming a component of the dominant auto-epitopes...
- The major protein of bovine seminal plasma, PDC-109, is a molecular chaperoneRajeshwer Singh Sankhala
School of Chemistry, University of Hyderabad, Hyderabad 500046, India
Biochemistry 49:3908-18. 2010The major protein of bovine seminal plasma, PDC-109, binds to choline phospholipids on the sperm plasma membrane and induces the efflux of cholesterol and choline phospholipids, which is an important step in sperm capacitation...
- Localization and regulation of plasma membrane Ca(2+)-ATPase in bovine spermatozoaJörg Triphan
Department of Anatomy and Cell Biology, Philipps University, Robert Koch Str 8, D 35037 Marburg, Germany
Eur J Cell Biol 86:265-73. 2007..We have recently shown that bovine sperm PMCA is stimulated by PDC-109, a secretory protein of bovine seminal vesicles...
- Characterization of the p-coumaric acid decarboxylase from Lactobacillus plantarum CECT 748(T)Hector Rodriguez
Departamento de Microbiologia, Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
J Agric Food Chem 56:3068-72. 2008..The p-coumaric acid decarboxylase (PDC) from this strain has been overexpressed and purified...
- Regulation of pyruvate dehydrogenase complex activity in Ehrlich ascites carcinoma cells by Ca2+ and pyruvateG L Ermakov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142292, Russia
Biochemistry (Mosc) 64:318-25. 1999The dependence of pyruvate dehydrogenase complex (PDC) activity on [Ca2+] was determined in Ehrlich ascites carcinoma cells at different pyruvate concentrations...
- Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activityR Max Wynn
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9038, USA
J Biol Chem 283:25305-15. 2008Human pyruvate dehydrogenase complex (PDC) is down-regulated by pyruvate dehydrogenase kinase (PDK) isoforms 1-4. PDK4 is overexpressed in skeletal muscle in type 2 diabetes, resulting in impaired glucose utilization...
- Circulating myeloid dendritic cells are increased in individuals with severe aplastic anemiaShao Zonghong
Department of Hematology, General Hospital, Tianjin Medical University, 154 Anshandao, Tianjin 300052, Heping, People s Republic of China
Int J Hematol 93:156-62. 2011..of the study were to investigate the number of myeloid dendritic cells (mDC) and plasmacytoid dendritic cells (pDC) present in peripheral blood mononuclear cells (PBMC) from severe aplastic anemia (SAA) patients before and after ..
- Type I interferon-dependent gene MxA in perinatal HIV-infected patients under antiretroviral therapy as marker for therapy failure and blood plasmacytoid dendritic cells depletionRaffaele Badolato
Istituto di Medicina Molecolare Angelo Nocivelli, Department of Pediatrics, University of Brescia, Brescia 25123, Italy
J Transl Med 6:49. 2008..in controlling HIV infection we phenotypically and functionally analyzed circulating plasmacytoid dendritic cells (pDC), which are known to be the highest interferon-alpha producing cells, in 33 perinatally infected HIV+ patients ..
- Anti-CD25 mAb, anti-IL2 mAb, and IL2 block tolerance induction through anti-CD154 mAb and rapamycin in xenogeneic islet transplantationH Pan
Department of General Surgery West China Hospital, Si Chuan University, Chengdu, Sichuan, China
Transplant Proc 39:3452-4. 2007We have used anti-CD154 monoclonal antibody (mAb; MR1) and rapamycin (rapa) to induce tolerance to islet xenografts...
- Comparing adherence and persistence across 6 chronic medication classesJason Yeaw
IMS Health, 311 Arsenal St, Watertown, MA 02472, USA
J Manag Care Pharm 15:728-40. 2009The National Quality Forum recently endorsed the proportion of days covered (PDC)-a measure of medication adherence-as an indicator of quality in drug therapy management.
- Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosisAkira Kawano
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
J Immunol 179:3315-24. 2007Primary biliary cirrhosis is characterized by autoreactive T cells specific for the mitochondrial Ag PDC-E2(163-176)...
- Peripheral blood T-cell responses to pyruvate dehydrogenase complex in primary biliary cirrhosis: role of antigen-presenting dendritic cellsS M Akbar
Ehime University School of Medicine, Ehime, Japan, Teikyo University Mizonokuchi Hospital, Kanagawa, Japan
Eur J Clin Invest 31:639-46. 2001..biliary cirrhosis (PBC) are usually characterized by the presence of antibody to pyruvate dehydrogenase complex (PDC) in the sera and PDC-specific T cells in the liver...
- Plasmacytoid dendritic cell dynamics tune interferon-alfa production in SIV-infected cynomolgus macaquesTimothée Bruel
Division of Immuno Virology, Institute of Emerging Diseases and Innovative Therapies, CEA, Fontenay aux Roses, France Unité Mixte de Recherche UMR E01, Universite Paris Sud, Orsay, France
PLoS Pathog 10:e1003915. 2014..However, acute IFN-I plasma concentrations rapidly decline thereafter. Plasmacytoid dendritic cells (pDC) are key players in this production but primary infection is associated with decreased responsiveness of pDC to TLR ..
- Myofibrillogenesis regulator-1 overexpression is associated with poor prognosis of gastric cancer patientsJing Guo
Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Gastrointestinal Surgery, Peking University Cancer Hospital, Beijing Cancer Hospital and Institute, Beijing 100142, China
World J Gastroenterol 18:5434-41. 2012..To investigate the expression of myofibrillogenesis regulator-1 (MR-1) in relation to clinicopathological parameters and postoperative survival in a group of Chinese patients with gastric cancer...
- Molecular recognition modes between adenine or adeniniun(1+) ion and binary M(II)(pdc) chelates (MCoZn; pdc=pyridine-2,6-dicarboxylate(2-) ion)María Del Pilar Brandi-Blanco
Department of Inorganic Chemistry, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain Electronic address
J Inorg Biochem 127:211-9. 2013Mixed ligand M(II)-complexes (MCoZn) with pyridine-2,6-dicarboxylate(2-) chelator (pdc) and adenine (Hade) have been synthesized and studied by X-ray diffraction and other spectral and thermal methods: [Cu(pdc)(H(N9)ade)(H2O)] (1), [Cu2(..
- Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cellsMiren Kerkmann
Department of Internal Medicine, Division of Clinical Pharmacology, University of Munich, Munich, Germany
J Immunol 170:4465-74. 2003..CpG oligonucleotides (ODN) were used to study the regulation of type I IFN in human plasmacytoid dendritic cells (PDC): ODN 2216, a CpG-A ODN, known to induce high amounts of IFN-alpha in PDC, and ODN 2006, a CpG-B ODN, which is ..
- Collaborative action of NF-kappaB and p38 MAPK is involved in CpG DNA-induced IFN-alpha and chemokine production in human plasmacytoid dendritic cellsYouko Osawa
Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, 23 3 Matsuoka Shimoaizuki, Eiheiji cho, Yoshida gun, Fukui 910 1193, Japan
J Immunol 177:4841-52. 2006CpG DNA induces plasmacytoid dendritic cells (pDC) to produce type I IFN and chemokines. However, it has not been fully elucidated how the TLR9 signaling pathway is linked to these gene expressions...
- Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its Lactobacillus mimicDimitrios Petrou Bogdanos
Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
Hepatology 42:458-65. 2005..hallmark of primary biliary cirrhosis (PBC) is the presence of pyruvate dehydrogenase complex E2 subunit (PDC-E2) antimitochondrial antibodies (AMAs)...
- Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosisHiroto Kita
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, California 95616, USA
J Clin Invest 109:1231-40. 2002..in the liver that are specific for peptides encoded by the E2 components of the pyruvate dehydrogenase complexes (PDC-E2)...
- Contrasting effects of submergence in light and dark on pyruvate decarboxylase activity in roots of rice lines differing in submergence toleranceBijayalaxmi Mohanty
Department of Biological Sciences, National University of Singapore, Science Drive 4, Singapore 117543, Republic of Singapore
Ann Bot 91:291-300. 2003..In all lines, activity of pyruvate decarboxylase (PDC), extracted from the apical 3-5 cm of root axes, decreased by 46-96 % and 38-76 %, respectively, during 5 or 10 d ..
- Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neuronsToshiyuki Himi
Section of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
J Neurosci Res 71:679-88. 2003..We sought evidence that L-trans-pyrrolidine-2,4-dicarboxylate (PDC) enhances glutamate-induced neuronal damage not only via the N-methyl-D-aspartate (NMDA) receptor mediated pathway, ..
- Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic miceTeresa A Hopkins
Departments of Pharmacology and Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
Am J Physiol Heart Circ Physiol 285:H270-6. 2003The pyruvate dehydrogenase enzyme complex (PDC) is rate limiting for glucose oxidation in the heart...
- Cloning and characterization of the Zymobacter palmae pyruvate decarboxylase gene (pdc) and comparison to bacterial homologuesKrishnan Chandra Raj
Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida 32611 0700, USA
Appl Environ Microbiol 68:2869-76. 2002Pyruvate decarboxylase (PDC) is the key enzyme in all homo-ethanol fermentations. Although widely distributed among plants, yeasts, and fungi, PDC is absent in animals and rare in bacteria (established for only three organisms)...
- Longitudinal changes of peritoneal function calculated by personal dialysis capacity in a patient after long-term continuous ambulatory peritoneal dialysisHidetomo Nakamoto
Department of Nephrology, Saitama Medical School, Saitama, Japan
Adv Perit Dial 19:97-102. 2003..we investigated longitudinal changes in peritoneal function, as calculated by the personal dialysis capacity (PDC) test, after patient withdrawal from 17 years of continuous ambulatory peritoneal dialysis (CAPD)...
- Role of the isoprenyl pocket of the G protein beta gamma subunit complex in the binding of phosducin and phosducin-like proteinGeorgi L Lukov
Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
Biochemistry 43:5651-60. 2004Phosducin (Pdc) and phosducin-like protein (PhLP) regulate G protein-mediated signaling by binding to the betagamma subunit complex of heterotrimeric G proteins (Gbetagamma) and removing the dimer from cell membranes...
- Purification, characterization, cloning and expression of pyruvate decarboxylase from Torulopsis glabrata IFO005Qinhong Wang
Center for Microbial Biotechnology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, P R China
J Biochem 136:447-55. 2004..production of pyruvate and optically active alpha-hydroxy ketones by Torulopsis glabrata, pyruvate decarboxylase (PDC, EC 4.1.1...
- Relationship between peripheral blood dendritic cells and cytokines involved in the pathogenesis of systemic lupus erythematosusEwa Robak
Department of Dermatology and Venerology, Medical University of Łódź, ul Krzemieniecka 5, 94 017 Łódź, Poland
Eur Cytokine Netw 15:222-30. 2004..In this study we investigated the relationship between the total number of DC (tDC), and their plasmacytoid (pDC) and myeloid (mDC) subpopulations, with serum concentrations of interferons (IFN-alpha and IFN-gamma) and selected ..
- A key role for autoreactive B cells in the breakdown of T-cell tolerance to pyruvate dehydrogenase complex in the mouseAmanda J Robe
Liver Research Group, University of Newcastle, Newcastle upon Tyne, UK
Hepatology 41:1106-12. 2005..liver disease primary biliary cirrhosis is breakdown of T-cell self-tolerance to pyruvate dehydrogenase complex (PDC). The mechanism resulting in this breakdown of tolerance remains unclear...
- A flow cytometric method for determination of absolute counts of myeloid precursor dendritic cells in peripheral bloodLing Ma
Laboratory for Experimental Hematology, University of Leuven, University Hospital Leuven, Leuven, Belgium
J Immunol Methods 285:215-21. 2004..They have a typical immunophenotypic profile, yet, they cannot be identified by pDC-specific immunophenotypic markers and therefore, their accurate and absolute enumeration poses a challenge...
- Vehicle exhaust gas clearance by low temperature plasma-driven nano-titanium dioxide film prepared by radiofrequency magnetron sputteringShuang Yu
Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
PLoS ONE 8:e59974. 2013A novel plasma-driven catalysis (PDC) reactor with special structure was proposed to remove vehicle exhaust gas...
- Antiviral vaccines license T cell responses by suppressing granzyme B levels in human plasmacytoid dendritic cellsDorit Fabricius
Department of Pediatrics, University Medical Center Ulm, 89075 Ulm, Germany
J Immunol 191:1144-53. 2013Human plasmacytoid dendritic cells (pDC) are important modulators of adaptive T cell responses during viral infections...
- Myofibrillogenesis regulator 1 gene (MR-1) mutation in an Omani family with paroxysmal nonkinesigenic dyskinesiaAnne Hempelmann
Gene Mapping Center, Max Delbruck Center for Molecular Medicine, Department of Neurology, Charite University Medicine, Berlin, Germany, and Department of Neurology, The Royal Hospital, Muscat, Oman
Neurosci Lett 402:118-20. 2006Two recurrent missense mutations (c.20C>T: A7V; c.26C>T: A9V) in the gene encoding the myofibrillogenesis regulator 1 (MR-1) have been shown to cause autosomal dominant paroxysmal nonkinesigenic dyskinesia (PNKD) in 13 families of ..
- Chronic immune activation in HIV-1 infection contributes to reduced interferon alpha production via enhanced CD40:CD40 ligand interactionNorbert Donhauser
Institute of Clinical and Molecular Virology, German National Reference Centre for Retroviruses, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
PLoS ONE 7:e33925. 2012..IFN-)alpha production is observed in HIV-1 infection, the response of circulating plasmacytoid dendritic cells (PDC) to Toll-like receptor ligand stimulation is substantially impaired...
- Top-down mass spectrometry reveals new sequence variants of the major bovine seminal plasma protein PDC-109Mikko Laitaoja
Department of Chemistry, University of Eastern Finland, FI 80101, Joensuu, Finland
J Mass Spectrom 47:853-9. 2012The major protein of bovine seminal plasma, PDC-109, is a 109-residue polypeptide that exists as a polydisperse aggregate under native conditions...
- Type III IFNs are produced by and stimulate human plasmacytoid dendritic cellsZhiwei Yin
Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
J Immunol 189:2735-45. 2012Plasmacytoid dendritic cells (pDC) are rare cells found in peripheral blood and lymphoid tissues...
- MAIT cell recognition of MR1 on bacterially infected and uninfected cellsMary H Young
Integrated Department of Immunology, National Jewish Health and University of Colorado School of Medicine, Denver, Colorado, United States of America
PLoS ONE 8:e53789. 2013..population of T cells that express a semi-invariant αβ TCR and are restricted by the MHC class I-related molecule MR1. MAIT cells recognize uncharacterized ligand(s) presented by MR1 through the cognate interaction between their TCR ..
- Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretionM C Sugden
Department of Diabetes and Metabolic Medicine, Division of General and Developmental Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London, U K
Diabetes 50:2729-36. 2001The pyruvate dehydrogenase complex (PDC) has a pivotal role in islet metabolism. The pyruvate dehydrogenase kinases (PDK1-4) regulate glucose oxidation through inhibitory phosphorylation of PDC...
- Mycoplasma antigens as a possible trigger for the induction of antimitochondrial antibodies in primary biliary cirrhosisChristoph P Berg
Department of Internal Medicine I, Medical Clinic, Eberhard Karls University of Tubingen, Tubingen, Germany
Liver Int 29:797-809. 2009In primary biliary cirrhosis (PBC), autoreactivity mainly targets members of the pyruvate dehydrogenase complex (PDC)...
- Plasmacytoid DC promote priming of autoimmune Th17 cells and EAEMagnus Isaksson
Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden
Eur J Immunol 39:2925-35. 2009..To investigate the role of plasmacytoid DC (pDC) in the initiation of autoimmune Th17- and Th1-cell responses and EAE, we depleted pDC with anti-pDC Ag-1 (anti-..
- Regulation of alcoholic fermentation in coleoptiles of two rice cultivars differing in tolerance to anoxiaJ Gibbs
Faculty of Agriculture Plant Sciences, University of Western Australia, Nedlands, Australia
J Exp Bot 51:785-96. 2000..ATP-dependent phosphofructokinase (PFK), pyrophosphate-dependent phosphofructokinase (PFP), pyruvate decarboxylase (PDC), and alcohol dehydrogenase (ADH)...
- Extended causal modeling to assess Partial Directed Coherence in multiple time series with significant instantaneous interactionsLuca Faes
Lab Biosegnali, Department of Physics and BIOtech, University of Trento, Via delle Regole 101, 38123, Mattarello, Trento, Italy
Biol Cybern 103:387-400. 2010The Partial Directed Coherence (PDC) and its generalized formulation (gPDC) are popular tools for investigating, in the frequency domain, the concept of Granger causality among multivariate (MV) time series...
- Malposition of unerupted mandibular second premolar in children with palatally displaced caninesMiri Shalish
Department of Orthodontics, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel
Angle Orthod 79:796-9. 2009..of unerupted mandibular premolar (MnP2) is significantly greater in children with palatally displaced canines (PDC) than in those in a control sample; and (2) delayed tooth formation is significantly more frequent in children with ..
- Role for plasmacytoid dendritic cells in the immune control of recurrent human herpes simplex virus infectionHeather Donaghy
Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
J Virol 83:1952-61. 2009Plasmacytoid dendritic cells (pDC) are an important component of the innate immune response, producing large amounts of alpha interferon in response to viral stimulation in vitro...
- Rapid influx and death of plasmacytoid dendritic cells in lymph nodes mediate depletion in acute simian immunodeficiency virus infectionKevin N Brown
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS Pathog 5:e1000413. 2009Plasmacytoid dendritic cells (pDC) are essential innate immune system cells that are lost from the circulation in human immunodeficiency virus (HIV)-infected individuals associated with CD4(+) T cell decline and disease progression...
- 31P NMR and AFM studies on the destabilization of cell and model membranes by the major bovine seminal plasma protein, PDC-109Rajani S Damai
School of Chemistry, University of Hyderabad, Hyderabad 500 046, India
IUBMB Life 62:841-51. 2010The effect of PDC-109 binding to dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylglycerol (DPPG) multilamellar vesicles (MLVs) and supported membranes was investigated by (31)P NMR spectroscopy and atomic force ..
- Plasmacytoid dendritic cells are dispensable during primary influenza virus infectionAmaya I Wolf
Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA
J Immunol 182:871-9. 2009Plasmacytoid dendritic cells (pDC) are thought to be pivotal in the first line of defense against viral infections...
- Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complexChad A Brautigam
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Biol Chem 284:13086-98. 2009The human pyruvate dehydrogenase complex (PDC) is a 9.5-megadalton catalytic machine that employs three catalytic components, i.e...
- NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulationAntonino Castellaneta
Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Immunol 183:6922-32. 2009..Following MDP stimulation in vivo, liver pDC, but not mDC, up-regulated expression of IFN regulatory factor 4 (IRF-4), a negative regulator of TLR signaling, ..
- Damage and repair of nerve cell DNA in toxic stressG E Kisby
Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
Drug Metab Rev 31:589-618. 1999It is generally agreed that ALS/PDC is triggered by a disappearing environmental factor peculiar to the lifestyle of people of the western Pacific (i.e., Guam, Irian Jaya, Indonesia, and the Kii Peninsula of Japan)...
- Single dose parenteral hyposensitization to poison ivy urushiol in guinea pigsL A Walker
Research Institute of Pharmaceutical Sciences, University of Mississippi, University 38677, USA
Immunopharmacol Immunotoxicol 17:565-76. 1995..three different analogs of poison ivy urushiol were studied: 1) a mixture of pentadecyl and heptadecyl catechols (PDC/HDC), the saturated side chain analog of the natural urushiol mixture; 2) a mixture of the diacetate esters of PDC ..
- ALS-parkinsonism-dementia complex of Kii and other related diseases in JapanRyuji Kaji
Department of Neurology, Tokushima University Hospital, Japan
Parkinsonism Relat Disord 18:S190-1. 2012The ALS/parkinsonism-dementia complex (PDC) of Kii is an endemic disease with a diverse phenotypic expression characteristic of classical ALS, parkinsonism and dementia...
- Plasmacytoid dendritic cells protect against atherosclerosis by tuning T-cell proliferation and activityIsabelle T M N Daissormont
Department of Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
Circ Res 109:1387-95. 2011Unlike conventional dendritic cells, plasmacytoid DCs (PDC) are poor in antigen presentation and critical for type I interferon response...
- Efficient sensing of avian influenza viruses by porcine plasmacytoid dendritic cellsMichael Bel
Institute of Virology and Immunoprophylaxis, Mittelhausern, Switzerland
Viruses 3:312-30. 2011..Among the cells involved in the cytokine storm, plasmacytoid dendritic cells (pDC) could play an important role considering their unique capacity to secrete massive amounts of type I interferon (..
- Quantitative and functional alterations of plasmacytoid dendritic cells contribute to immune tolerance in ovarian cancerSana Intidhar Labidi-Galy
Departments of Medical Oncology, Centre de Recherche en Cancérologie de Lyon, Centre Leon Berard, Lyon, France
Cancer Res 71:5423-34. 2011..In this study, we investigated the contribution of plasmacytoid dendritic cells (pDC) in the establishment of immune tolerance in a cohort of 44 ovarian cancer patients...
- Identification of a lineage negative cell population in bovine peripheral blood with the ability to mount a strong type I interferon responseAmanda Gibson
The Royal Veterinary College, North Mymms, Hatfield, Hertfordshire, UK
Dev Comp Immunol 36:332-41. 2012..dendritic cells, or natural interferon-producing cells (NIPC), also referred to as plasmacytoid dendritic cells (pDC) constitute a small population of leukocytes secreting high levels of type I interferon (IFNα/β) in response to ..
- Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunityLisa K Ryan
The Public Health Research Institute and Department of Medicine, Division of Pulmonary and Critical Care Medicine, New Jersey Medical School, Newark, NJ 07103, USA
J Leukoc Biol 90:343-56. 2011..constitutively expressed in most cells in spite of cytokine or LPS stimulation; however, its presence in human PDC suggests it plays a role in viral host defense...
- Hepatitis B virus lacks immune activating capacity, but actively inhibits plasmacytoid dendritic cell functionAndrea M Woltman
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
PLoS ONE 6:e15324. 2011..Activation of plasmacytoid dendritic cells (pDC) leading to IFNα production is important for effective anti-viral immunity...
- Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementiaPurnima Desai Sundar
Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA 98195, USA
Hum Mol Genet 16:295-306. 2007Unusual forms of amyotrophic lateral sclerosis (ALS-G), Parkinsonism dementia complex (PDC-G) and Guam dementia (GD) are found in Chamorros, the indigenous people of Guam...
- Technical advance: Generation of human pDC equivalents from primary monocytes using Flt3-L and their functional validation under hypoxiaDivya Sekar
Institute of Biochemistry I ZAFES, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
J Leukoc Biol 88:413-24. 2010..mDC are efficient in antigen presentation, whereas pDC act as rheostats of the immune system...
- Biochemistry and autoimmune response to the 2-oxoacid dehydrogenase complexes in primary biliary cirrhosisM F Bassendine
Department of Medicine, Medical School, University of Newcastle, Newcastle upon Tyne, U K
Semin Liver Dis 17:49-60. 1997Pyruvate dehydrogenase complex (PDC), 2-oxo-glutarate dehydrogenase complex (OGDC), and the branched-chain 2-oxoacid dehydrogenase complex (BCOADC) constitute the 2-oxoacid dehydrogenase family of multienzyme complexes...
- Inability of plasmacytoid dendritic cells to directly lyse HIV-infected autologous CD4+ T cells despite induction of tumor necrosis factor-related apoptosis-inducing ligandJihed Chehimi
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Virol 84:2762-73. 2010The function of plasmacytoid dendritic cells (PDC) in chronic human immunodeficiency virus type 1 (HIV-1) infection remains controversial with regard to its potential for sustained alpha interferon (IFN-alpha) production and induction of ..
- Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, ObesitRobert A Harris; Fiscal Year: 2012..The activity of the pyruvate dehydrogenase complex (PDC) is tightly regulated by phosphorylation by the PDKs...
- MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSISMERRILL E GERSHWIN; Fiscal Year: 2013..AMAs), which react specifically with the lipoyl domain of the pyruvate dehydrogenase complex E2 subunit (PDC-E2)...
- Human Beta-Defensin-1 in HSV-1 Innate ImmunityLISA KATHLEEN RYAN; Fiscal Year: 2010..One type of DC, the plasmacytoid DC (PDC) is important in innate immune function through the production of interferon-? (IFN) induced by enveloped viruses ..
- Interactions of pDCs with AspergilusSTUART MICHAEL LEVITZ; Fiscal Year: 2013..fumigatus-induced pDC death;2) following stimulation with A...
- Pathways regulating plasmacytoid dendritic cells in Peyers PatchesStephanie S Watowich; Fiscal Year: 2013..The pDC developmental pathway proceeds through a common DC progenitor (CDP), which generates both pDCs and conventional DCs...
- The role of plasmacytoid dendritic cells in corneal immunityPedram Hamrah; Fiscal Year: 2013DESCRIPTION (provided by applicant): Plasmacytoid dendritic cells (pDC), a distinct type of bone marrow-derived cell, play an important role in linking innate and adaptive immune responses...
- Understanding the early and late endosomal TLR9-mediated responses to viral DNA.Yong Jun Liu; Fiscal Year: 2013..The first aim will focus on the potential role of in CpG ODN trafficking by using a human pDC cell line with stable knockdown of PACSIN1 expression by shRNA and mouse pDCs derived from PACSIN-deficient mice...
- Plasmacytoid Dendritic Cells in HIV PathogenesisPatricia Fitzgerald-Bocarsly; Fiscal Year: 2013DESCRIPTION (provided by applicant): Plasmacytoid dendritic cells (pDC) are the most potent type I interferon (IFN)- producing cells in the body and are considered to be the "professional IFN producing cells"...
- IMPACT OF PLASMACYTOID DENDRITIC CELLS ON TYPE I DIABETES PATHOGENESISMelissa Swiecki; Fiscal Year: 2013..Plasmacytoid dendritic cells (pDC) have been identified as a major source of IFN-I in diabetic mouse models and an expansion of IFN-I-producing pDC ..
- Viral Gastroenteritis: Basis of Protection and VirulenceHARRY BERNARD GREENBERG; Fiscal Year: 2013..the interaction of murine plasmacytoid dendritic cells (pDCs) with RV and determine the contribution of pDC-derived interferon to restricting RV infection...
- Immune function and the progression to type 1 diabetesMark A Atkinson; Fiscal Year: 2013..defects in type 1 IFN biology, hyperactive IFN[unreadable]/[unreadable] responses and increased plasmacytoid DC (PDC)/IFN[unreadable]/[unreadable] production in the islet microenvironment play a critical role in T1D pathogenesis...
- CHARACTERIZATION OF A NEW FAMILY OF PROTEIN KINASESKirill M Popov; Fiscal Year: 2012DESCRIPTION (provided by applicant): The reaction catalyzed by mitochondrial pyruvate dehydrogenase complex (PDC) links glycolysis and Citric Acid Cycle...
- Immunogenetic Control of Autoimmune Liver DiseaseWilliam M Ridgway; Fiscal Year: 2013..ABD" mice) that develop spontaneous, autoimmune biliary disease (ABD) and anti-pyruvate dehydrogenase complex (PDC) autoantibodies, and serve as a model of human primary biliary cirrhosis (PBC)...
- The Role of C-C Chemokines in Eosinophil Airway InflammationNicholas W Lukacs; Fiscal Year: 2012..To identify the differential role of chemokines for DC subset, pDC vs. cDC, trafficking to the lungs and activation leading to altered pulmonary responses...
- Innate immune mechanisms in dengue infectionKovit Pattanapanyasat; Fiscal Year: 2013..with Fas-L expressing NK cells c) there is a marked increase in the frequencies of plamacytoid dendritic cells (pDC's) which express immature phenotype d) there is a muted memory B cell response against the heterologous dengue ..
- Post-transcriptional regulation of the Dendritic Cell transcriptomeMiriam Merad; Fiscal Year: 2013..that are specialized in the cross-presentation of cell associated antigens to CD8+ T cells, and plasmacytoid DC (pDC), which help to establish an antiviral state through the rapid secretion of high amounts of interferon alpha...
- Autophagy in Antiviral ImmunityAkiko Iwasaki; Fiscal Year: 2013..In professional viral sensors, the plasmacytoid dendritic cells (pDC), recognition of viruses occurs in the endosomes via Toll-like receptors (TLR) 7 and 9...
- Novel mechanisms of mitochondrial regulation by sirtuin deacetylasesDAVID BENNER LOMBARD; Fiscal Year: 2013..plays a hitherto undescribed role in deacetylating and suppressing activity of Pyruvate Dehydrogenase Complex (PDC), a mitochondrial holoenzyme with a major role in regulating glucose oxidation in mammalian cells...
- Molecular Control of Plasmacytoid Dendritic Cell Development and FunctionBoris Reizis; Fiscal Year: 2013..Virus-induced IFN production by pDCs is critical for the control of viral infections, whereas aberrant pDC activation is associated with autoimmune diseases...
- Plasmacytoid Dendritic Cells and Their Role in Transplant ToleranceAudrey H Lau; Fiscal Year: 2013..It has been hypothesized that immature pDC are inherently tolerogenic...
- Dissecting Dendritic Cell Function in Autoimmune DiabetesJONATHAN DAVID KATZ; Fiscal Year: 2013..Conversely, depleting plasmacytoid DC (pDC) exacerbates the pathology- increasing both the number and severity of infiltrated islets, suggesting that, once ..
- AAV-Based Plasmacytoid Dendritic Cell Cancer VaccinePierre L Triozzi; Fiscal Year: 2010..There is experimental evidence suggesting that the plasmacytoid DC subpopulation (pDC) plays an important role in regulating the T-helper (Th) polarization of the immune response...
- T cell depletion in older HIV-infected patients by plasmacytoid dendritic cellsVIRIAN DAVY SEREI; Fiscal Year: 2013..Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons and are also known to express TRAIL during HIV infection...
- HCV, Alcohol and Host DefenseGyongyi Szabo; Fiscal Year: 2013..We hypothesize that HCV-mediated signals play a role in HCV-induced alterations in dendritic cells (mDCI, mDC2, pDC) and contribute to the reduced T cell responses in HCV infection by induction of CD4+CD25+ regulatory T cells...
- Targeting Plasmacytoid Dendritic Cells to Treat Human MyelomaQing Yi; Fiscal Year: 2013..However, several recent studies have also identified pDC as critical players in oral and airway tolerance...
- HIV and Plasmacytoid dendritic cells in the thymusChristel Uittenbogaart; Fiscal Year: 2007Plasmacytoid dendritic cells (pDC) are lymphoid dendritic cells that express high levels of interleukin 3 (IL-3) receptor (CD 123) and produce type I interferons, cytokines with antiviral and immunoregulatory effects, pDC are present in ..
- HIV Dysregulation of Human Plasmacytoid Dendritic CellsMEAGAN O'BRIEN; Fiscal Year: 2013..candidate's proposed research project centers on the idea that HIV dysregulates plasmacytoid dendritic cells (pDC) to activate deficient adaptive immune responses while stimulating persistent interferon-alpha (IFNa) production, ..
- Role of Peripheral Dendritic Cells in Central and Oral ToleranceHusein Hadeiba; Fiscal Year: 2013DESCRIPTION (provided by applicant): We have identified a potent tolerogenic plasmacytoid dendritic cell (pDC) population defined by expression of the chemokine receptor CCR9, and have shown that these CCR9+ pDCs not only induce ..
- The Role of miRNA in Dendritic Cell FunctionGREGORY MULLOKANDOV; Fiscal Year: 2013..Plasmacytoid DC (pDC) is a major subset of DCs and are one of the earliest defenses of the body against specific pathogens...
- Retrovirus Isolation from Primary Biliary CirrhosisAndrew Mason; Fiscal Year: 2004..of patients develop anti-mitochondrial antibodies (AMA) reactive to pyruvate dehydrogenase complex E2 component (PDC-E2), which is aberrantly expressed on cell surface of biliary epithelial cells of patients with PBC...
- XENOBIOTICS AND PRIMARY BILIARY CIRRHOSISMERRILL E GERSHWIN; Fiscal Year: 2013..by breach of tolerance to the major mitochondrial autoantigen, the E2 component of pyruvate dehydrogenase (PDC-E2)...
- INBORN ERRORS OF METABOLISM IN CELL CULTUREDavid T Chuang; Fiscal Year: 2010..comprises the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), the pyruvate dehydrogenase complex (PDC) and the alpha-ketoglutarate dehydrogenase complex (KGDC)...
- HIV and Plasmacytoid dendritic cells in the thymusChristel Uittenbogaart; Fiscal Year: 2002Plasmacytoid dendritic cells (pDC) or natural interferon type I producing cells play an important role in linking innate and acquired immunity...
- REGULATION OF MAMMALIAN PYRUVATE DEHYDROGENASETHOMAS ROCHE; Fiscal Year: 2004The mammalian pyruvate dehydrogenase complex (PDC) connects glycolysis to oxidative metabolism and fatty acid synthesis with the irretrievable loss of glucose carbons...
- INBORN ERRORS OF PYRUVATE METABOLISMMulchand Patel; Fiscal Year: 1999The pyruvate dehydrogenase complex (PDC) plays a pivotal role in the metabolism of pyruvate for energy production and for biosynthetic processes...
- REGULATION OF MAMMALIAN DIHYDROLIPOAMIDE DEHYDROGENASEMulchand Patel; Fiscal Year: 2002..In eukaryotic pyruvate dehydrogenase complex (PDC), E3 binds to an E3-binding protein (E3BP)...
- 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASEJAMES STOOPS; Fiscal Year: 2001..Mammalian pyruvate dehydrogenase complex (PDC) plays a critical role in regulating cellular fuel utilization in the heart and, therefore, studies of the ..
- 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASEJAMES STOOPS; Fiscal Year: 2002..Mammalian pyruvate dehydrogenase complex (PDC) plays a critical role in regulating cellular fuel utilization in the heart and, therefore, studies of the ..
- The endosomal SLC15A4 proton-coupled histidine transporter in lupusArgyrios N Theofilopoulos; Fiscal Year: 2013..Among the innate immune cells implicated in the pathogenesis of lupus is the plasmacytoid dendritic cell (pDC) which constitute a small (<1%), but distinct population of cells that is thought to be activated by nucleic ..
- VOLATILE ACID FORMATION IN PARASITIC HELMINTHSRichard Komuniecki; Fiscal Year: 2004..novel anaerobic mitochondria present in the parasitic nematode, Ascaris suum: The pyruvate dehydrogenase complex (PDC) plays a key role in regulating these anaerobic mitochondrial pathways and its regulation and subunit composition ..
- Mechanisms of dysregulated immunity with aging.DANIEL ROBERT GOLDSTEIN; Fiscal Year: 2013..by using murine models to determine 1) if exaggerated inflammatory responses by NKT cells coupled to defective pDC responses are critical for the generation of IL-17 anti-viral CD4+ T cells during systemic herpes viral infections ..
- INBORN ERRORS OF THE PYRUVATE DEHYDROGENASE COMPLEXIsaiah Wexler; Fiscal Year: 1993The aim of the proposed project is to identify and analyze mutations responsible for pyruvate dehydrogenase complex (PDC) deficiency, an inherited disorder of energy metabolism which causes lactic acidosis and neurologic disability...
- GENETIC ANALYSIS OF PAROXYSMAL DYSTONIC CHOREOATHETOSISJohn Fink; Fiscal Year: 2000..The principal investigator proposes to study paroxysmal dystonic choreoathetosis (PDC), an inherited disorder characterized by attacks of involuntary movements that occur spontaneously at rest and ..
- Targeting pDCs for the Generation of Effective Anti-HCV CD8+ T-Cell ImmunityJohn Connolly; Fiscal Year: 2009..Furthermore we have demonstrated that targeting antigens to this compartment in an activated pDC is sufficient to initiate potent CD8+ T-cell responses...
- XENOBIOTICS AND PRIMARY BILIARY CIRRHOSISMERRILL GERSHWIN; Fiscal Year: 2001..AMAs are directed at the E2 components of the 2-oxo acid dehydrogenase pathway, particularly PDC-E2; 95 percent of patients with PBC have a positive AMA...
- A Revolutionary Therapy for Atherosclerosis: Liquid Cast Arterial StentsGuillermo A Ameer; Fiscal Year: 2010..We will use a biocompatible elastomeric citric acid-based polymer, polydiolcitrate (PDC) that will be diazeniumdiolated to spontaneously release nitric oxide (NO) when placed in the circulation...
- Phytoestrogen and Antioxidant Regulation of Prostate CancerDennis Lubahn; Fiscal Year: 2009..Exciting data from our model clearly show that ERalphaKO mice are highly protected against PDC (poorly differentiated carcinoma) of the prostate and ERbetaKO mice are highly susceptible to PDC...