PMEPA1

Summary

Gene Symbol: PMEPA1
Description: prostate transmembrane protein, androgen induced 1
Alias: STAG1, TMEPAI, protein TMEPAI, solid tumor-associated 1 protein, transmembrane, prostate androgen induced RNA
Species: human
Products:     PMEPA1

Top Publications

  1. Amalia R, Abdelaziz M, Puteri M, Hwang J, Anwar F, Watanabe Y, et al. TMEPAI/PMEPA1 inhibits Wnt signaling by regulating β-catenin stability and nuclear accumulation in triple negative breast cancer cells. Cell Signal. 2019;59:24-33 pubmed publisher
    Transmembrane prostate androgen-induced protein (TMEPAI) is a type I transmembrane protein induced by several intracellular signaling pathways such as androgen, TGF-β, EGF, and Wnt signaling...
  2. Xu X, Hirata H, Shiraki M, Kamohara A, Nishioka K, Miyamoto H, et al. Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption. FASEB J. 2019;33:4365-4375 pubmed publisher
    ..Prostate transmembrane protein androgen induced 1 (Pmepa1) is a type I transmembrane protein that regulates proliferation, migration, and metastasis of cancer cells...
  3. Ikeno S, Nakano N, Sano K, Minowa T, Sato W, Akatsu R, et al. PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-β (TGF-β) signaling. J Biol Chem. 2019;294:4966-4980 pubmed publisher
    ..enhanced the expression of the TGF-β target genes Smad7 and prostate transmembrane protein androgen-induced (TMEPAI) upon TGF-β stimulation...
  4. Kumari K, Das B, Adhya A, Rath A, Mishra S. Genome-wide expression analysis reveals six contravened targets of EZH2 associated with breast cancer patient survival. Sci Rep. 2019;9:1974 pubmed publisher
    ..In the present study, we validated six direct targets of EZH2 that are GPNMB, PMEPA1, CoL5A1, VGLL4, POMT2 and SUMF1 associated with cancer related pathways...
  5. Arnau Soler A, MacDonald Dunlop E, Adams M, Clarke T, MacIntyre D, Milburn K, et al. Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland. Transl Psychiatry. 2019;9:14 pubmed publisher
    ..but gene-based tests identified six genes associated with depressive symptoms in UK Biobank (DCC, ACSS3, DRD2, STAG1, FOXP2 and KYNU; p < 2.77 × 10-6)...
  6. Maind A, Raut S. Identifying condition specific key genes from basal-like breast cancer gene expression data. Comput Biol Chem. 2019;78:367-374 pubmed publisher
    ..Some of the important identified known key genes are PIK3CA, SHC3, ERBB2, SHC4, PTOV1, STAG1, ZNF215 etc...
  7. Li Y, Wang J, Song N, Zeng F, Zhao M, Wang A, et al. 2-(2-nitrobenzylidene) indolin-3-one compound inhibits transmembrane prostate androgen-induced protein (TMEPAI) expression and cancer cell proliferation. Cell Prolif. 2018;51:e12469 pubmed publisher
    The transmembrane prostate androgen-induced protein (TMEPAI) is aberrantly expressed in many cancer and plays a crucial role in tumourigenesis, which makes it a potential cancer therapeutic target for drug discovery...
  8. Yuan B, Neira J, Pehlivan D, Santiago Sim T, Song X, Rosenfeld J, et al. Clinical exome sequencing reveals locus heterogeneity and phenotypic variability of cohesinopathies. Genet Med. 2019;21:663-675 pubmed publisher
    ..Candidate or recently reported cohesinopathy genes were supported by de novo SNVs/indels in STAG1 (N = 3), STAG2 (N = 5), PDS5A (N = 1), and WAPL (N = 1), and one inherited SNV in PDS5A...
  9. Wolf P, Cuba Ramos A, Kenzel J, Neumann B, Stemmann O. Studying meiotic cohesin in somatic cells reveals that Rec8-containing cohesin requires Stag3 to function and is regulated by Wapl and sororin. J Cell Sci. 2018;131: pubmed publisher
    ..When expressed in Hek293 cells, the kleisin Rec8 displays no affinity for the peripheral cohesin subunits Stag1 or Stag2 and remains cytoplasmic...

More Information

Publications64

  1. Singha P, Pandeswara S, Geng H, Lan R, Venkatachalam M, Saikumar P. TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer. Genes Cancer. 2014;5:320-36 pubmed
    b>TMEPAI (transmembrane prostate androgen-induced) is amplified at genomic, transcript and protein levels in triple-negative breast cancers and promotes TGF-β dependent growth, motility and invasion...
  2. Sheffer M, Bacolod M, Zuk O, Giardina S, Pincas H, Barany F, et al. Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. Proc Natl Acad Sci U S A. 2009;106:7131-6 pubmed publisher
    ..potential new candidate tumor suppressors (losses) and oncogenes (gains), including CCDC68, CSMD1, POLR1D, and PMEPA1. From the expression data, we identified genes whose expression levels reflected their copy number changes and ..
  3. Du Y, Liu Y, Xu Y, Juan J, Zhang Z, Xu Z, et al. The transmembrane protein TMEPAI induces myeloma cell apoptosis by promoting degradation of the c-Maf transcription factor. J Biol Chem. 2018;293:5847-5859 pubmed publisher
    ..transmembrane prostate androgen-induced protein, also called prostate transmembrane protein, androgen-induced 1 (PMEPA1)) is a type I transmembrane (TM) protein, but its cellular function is largely unknown...
  4. Fournier P, Juarez P, Jiang G, Clines G, Niewolna M, Kim H, et al. The TGF-? Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone. Cancer Cell. 2015;27:809-21 pubmed publisher
    ..cells a set of genes associated with cancer aggressiveness and bone metastases, and the most upregulated gene was PMEPA1. In patients, PMEPA1 expression decreased in metastatic prostate cancer and low Pmepa1 correlated with decreased ..
  5. Kojic A, Cuadrado A, De Koninck M, Giménez Llorente D, Rodríguez Corsino M, Gomez Lopez G, et al. Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization. Nat Struct Mol Biol. 2018;25:496-504 pubmed publisher
    Two variant cohesin complexes containing SMC1, SMC3, RAD21 and either SA1 (also known as STAG1) or SA2 (also known as STAG2) are present in all cell types...
  6. Xu G, Zhang M, Zhu H, Xu J. A 15-gene signature for prediction of colon cancer recurrence and prognosis based on SVM. Gene. 2017;604:33-40 pubmed publisher
    ..signature (HES5, ZNF417, GLRA2, OR8D2, HOXA7, FABP6, MUSK, HTR6, GRIP2, KLRK1, VEGFA, AKAP12, RHEB, NCRNA00152 and PMEPA1) were identified as a predictor of recurrence risk and prognosis for colon cancer patients...
  7. Rani L, Mathur N, Gupta R, Gogia A, Kaur G, Dhanjal J, et al. Genome-wide DNA methylation profiling integrated with gene expression profiling identifies PAX9 as a novel prognostic marker in chronic lymphocytic leukemia. Clin Epigenetics. 2017;9:57 pubmed publisher
    ..Significant differences were observed in the mRNA expression of MEIS1, PMEPA1, SOX7, SPRY1, CDK6, TBX2, and SPRY2 genes in CLL cells as compared to B-..
  8. Benedetti L, Cereda M, Monteverde L, Desai N, Ciccarelli F. Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1. Oncotarget. 2017;8:37619-37632 pubmed publisher
    ..of cohesin and an emerging tumour suppressor, leads to synthetic dependency of mutated cancer cells on its paralog STAG1. STAG1 and STAG2 share high sequence identity, encode mutually exclusive cohesin subunits and retain partially ..
  9. Marcos Alcalde Í, Mendieta Moreno J, Puisac B, Gil Rodríguez M, Hernández Marcos M, Soler Polo D, et al. Two-step ATP-driven opening of cohesin head. Sci Rep. 2017;7:3266 pubmed publisher
    The cohesin ring is a protein complex composed of four core subunits: Smc1A, Smc3, Rad21 and Stag1/2. It is involved in chromosome segregation, DNA repair, chromatin organization and transcription regulation...
  10. Mannini L, Cucco F, Quarantotti V, Amato C, Tinti M, Tana L, et al. SMC1B is present in mammalian somatic cells and interacts with mitotic cohesin proteins. Sci Rep. 2015;5:18472 pubmed publisher
    ..maintenance of chromosome proteins, SMC1A and SMC3, the kleisin protein RAD21 and a fourth subunit either STAG1 or STAG2...
  11. Seaborne R, Strauss J, Cocks M, Shepherd S, O Brien T, van Someren K, et al. Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy. Sci Rep. 2018;8:1898 pubmed publisher
    ..Finally, genes; GRIK2, TRAF1, BICC1, STAG1 were epigenetically sensitive to acute exercise demonstrating hypomethylation after a single bout of resistance ..
  12. Mullegama S, Klein S, Mulatinho M, Senaratne T, Singh K, Nguyen D, et al. De novo loss-of-function variants in STAG2 are associated with developmental delay, microcephaly, and congenital anomalies. Am J Med Genet A. 2017;173:1319-1327 pubmed publisher
    ..The core of the complex consists of four subunits: SMC1A, SMC3, RAD21, and STAG1/2...
  13. Morton N, Nelson Y, Michailidou Z, Di Rollo E, Ramage L, Hadoke P, et al. A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies novel candidate obesity genes. PLoS ONE. 2011;6:e23944 pubmed publisher
    ..A number of novel obesity candidate genes were also identified (Thbs1, Ppp1r3d, Tmepai, Trp53inp2, Ttc7b, Tuba1a, Fgf13, Fmr) that have inferred roles in fat cell function...
  14. Ligthart S, Vaez A, Hsu Y, Stolk R, Uitterlinden A, Hofman A, et al. Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation. BMC Genomics. 2016;17:443 pubmed publisher
    ..6?×?10(-5)), STAG1/PCCB (rs7621025, Preplication: 1.4?×?10(-3)) and FTO (rs1558902, Preplication: 2.7?×?10(-5))...
  15. Lehalle D, Mosca Boidron A, Begtrup A, Boute Bénéjean O, Charles P, Cho M, et al. STAG1 mutations cause a novel cohesinopathy characterised by unspecific syndromic intellectual disability. J Med Genet. 2017;54:479-488 pubmed publisher
    ..So far, eight genes from this pathway have been reported in human disease. STAG1 belongs to the STAG subunit of the core cohesin complex, along with five other subunits...
  16. Jabbari K, Heger P, Sharma R, Wiehe T. The Diverging Routes of BORIS and CTCF: An Interactomic and Phylogenomic Analysis. Life (Basel). 2018;8: pubmed publisher
    ..The high expression of SPO11, RAE1, RBM38, and PMEPA1 in male tissues suggests a possible link between CTCFL, meiotic recombination, and fertility-associated phenotypes...
  17. França J, Diniz M, Bernardes V, Costa Silva R, Souza R, Gomez R, et al. Cohesin subunits, STAG1 and STAG2, and cohesin regulatory factor, PDS5b, in oral squamous cells carcinomas. J Oral Pathol Med. 2017;46:188-193 pubmed publisher
    Cohesin complex is responsible for sister chromatid cohesion. STAG1/STAG2 is part of the complex, which is regulated by PDS5B. Alterations in these genes were described in tumors. PDS5B is a negative regulator of cell proliferation...
  18. Karbyshev M, Grigoryeva E, Volkomorov V, Kremmer E, Huber A, Mitrofanova I, et al. Development of Novel Monoclonal Antibodies for Evaluation of Transmembrane Prostate Androgen-Induced Protein 1 (TMEPAI) Expression Patterns in Gastric Cancer. Pathol Oncol Res. 2018;24:427-438 pubmed publisher
    Transmembrane prostate androgen-induced protein 1 (TMEPAI) is a single-span membrane protein, functionally involved in transforming growth factor beta signaling pathway...
  19. Dijkstra J, Alexander D. The " NF-ĸ B interacting long noncoding RNA" ( NKILA) transcript is antisense to cancer-associated gene PMEPA1. F1000Res. 2015;4:96 pubmed publisher
    ..However, they entirely failed to mention PMEPA1, a gene which runs antisense to NKILA, and the expression of which is associated with several tumors and which ..
  20. Galeev R, Baudet A, Kumar P, Rundberg Nilsson A, Nilsson B, Soneji S, et al. Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs. Cell Rep. 2016;14:2988-3000 pubmed publisher
    ..A striking finding was the identification of members of the cohesin complex (STAG2, RAD21, STAG1, and SMC3) among the top 20 genes from the screen...
  21. Hill V, Kim J, Waldman T. Cohesin mutations in human cancer. Biochim Biophys Acta. 2016;1866:1-11 pubmed publisher
    ..cohesin is a ubiquitously expressed, multi-subunit protein complex composed of core subunits SMC1A, SMC3, RAD21, STAG1/2 and regulatory subunits WAPL, PDS5A/B, CDCA5, NIPBL, and MAU2...
  22. Nakano N, Kato M, Itoh S. Regulation of the TMEPAI promoter by TCF7L2: the C-terminal tail of TCF7L2 is essential to activate the TMEPAI gene. J Biochem. 2016;159:27-30 pubmed publisher
    We previously found that TCF7L2 could activate the TMEPAI gene efficiently, whereas LEF1 could not nearly augment its transcription...
  23. Li Y, Guo A, Feng Y, Zhang Y, Wang J, Jing L, et al. Sp1 transcription factor promotes TMEPAI gene expression and contributes to cell proliferation. Cell Prolif. 2016;49:710-719 pubmed publisher
    b>TMEPAI (transmembrane prostate androgen-induced protein) has been reported to be overexpressed during tumour progression; however, little is known concerning transcriptional mechanisms regulating TMEPAI gene expression...
  24. Kammula E, Mötter J, Gorgels A, Jonas E, Hoffmann S, Willbold D. Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins. PLoS ONE. 2012;7:e51578 pubmed publisher
    ..The identified hits are GPM6B, GPM6A, BAP31, TSPAN7, CYB5B, CD320/TCblR, VSIG4, PMEPA1, OCIAD1, ITGB1, CHN1, PH4, CLDN10, HSPA9, APR-3, PEBP1 and B3GNT, which are involved in diverse cellular processes ..
  25. Luo S, Yang M, Lv D, Jing L, Li Y, Liu Z, et al. TMEPAI increases lysosome stability and promotes autophagy. Int J Biochem Cell Biol. 2016;76:98-106 pubmed publisher
    ..Transmembrane prostate androgen-induced protein (TMEPAI) is a pro-tumorigenic factor with high expression in tumor cells...
  26. Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, et al. C18 ORF1, a novel negative regulator of transforming growth factor-? signaling. J Biol Chem. 2014;289:12680-92 pubmed publisher
    ..We recently identified transmembrane prostate androgen-induced RNA (TMEPAI), which is involved in a negative feedback loop of TGF-? signaling...
  27. Luo S, Jing L, Zhao T, Li Y, Liu Z, Diao A. Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking. Sci Rep. 2017;7:42668 pubmed publisher
    The transmembrane prostate androgen-induced protein (TMEPAI) has been reported to be elevated in various tumor cells, is localized to the lysosome and promotes lysosome stability...
  28. van der Lelij P, Lieb S, Jude J, Wutz G, Santos C, Falkenberg K, et al. Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts. elife. 2017;6: pubmed publisher
    ..subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interaction with its paralog STAG1...
  29. Nie Z, Wang C, Zhou Z, Chen C, Liu R, Wang D. Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression. Acta Biochim Biophys Sin (Shanghai). 2016;48:194-201 pubmed publisher
    The prostate transmembrane protein, androgen-induced 1 (PMEPA1) has been previously shown to promote solid malignancies in a variety of cancers, but the role and mechanisms of PMEPA1 in breast cancer has not been fully addressed...
  30. Li H, Mohamed A, Sharad S, Umeda E, Song Y, Young D, et al. Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN. Oncotarget. 2015;6:15137-49 pubmed
    ..regulation of AR protein levels in prostate cancer (CaP) cells through a negative feed-back loop between AR and PMEPA1, an androgen induced NEDD4 E3 ubiquitin ligase binding protein...
  31. Vo Nguyen T, Watanabe Y, Shiba A, Noguchi M, Itoh S, Kato M. TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells. Cancer Sci. 2014;105:334-41 pubmed publisher
    TMEPAI/PMEPA1 is a transmembrane protein that was originally identified as a prostatic RNA, the synthesis of which is induced by testosterone or its derivatives...
  32. Xu L, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, et al. PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. Cancer Res. 2003;63:4299-304 pubmed
    b>PMEPA1 was originally identified as a highly androgen-induced gene by serial analysis of gene expression in androgen-treated LNCaP prostate cancer (CaP) cells...
  33. Funakubo N, Xu X, Kukita T, Nakamura S, Miyamoto H, Kukita A. Pmepa1 induced by RANKL-p38 MAPK pathway has a novel role in osteoclastogenesis. J Cell Physiol. 2018;233:3105-3118 pubmed publisher
    ..expression and function of one of these highly expressed genes, prostate transmembrane protein androgen induced 1 (Pmepa1), a target of TGF-β and binds Nedd4 ubiquitin ligase, which plays a role in intracellular trafficking...
  34. Watanabe Y, Itoh S, Goto T, Ohnishi E, Inamitsu M, Itoh F, et al. TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. Mol Cell. 2010;37:123-34 pubmed publisher
    ..How TGF-beta signals are attenuated and terminated is not well understood. Here, we show that TMEPAI, a direct target gene of TGF-beta signaling, antagonizes TGF-beta signaling by interfering with TGF-beta type I ..
  35. Brunschwig E, Wilson K, Mack D, Dawson D, Lawrence E, Willson J, et al. PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer. Cancer Res. 2003;63:1568-75 pubmed
    ..b>PMEPA1 was identified as a gene highly up-regulated by TGF-beta treatment of VACO 330...
  36. Ward A, Hopkins J, McKay M, Murray S, Jordan P. Genetic Interactions Between the Meiosis-Specific Cohesin Components, STAG3, REC8, and RAD21L. G3 (Bethesda). 2016;6:1713-24 pubmed publisher
    ..SMC1α/SMC1β and SMC3), an α-kleisin protein (RAD21, RAD21L, or REC8), and a stromal antigen protein (STAG1, 2, or 3)...
  37. Bai X, Jing L, Li Y, Li Y, Luo S, Wang S, et al. TMEPAI inhibits TGF-? signaling by promoting lysosome degradation of TGF-? receptor and contributes to lung cancer development. Cell Signal. 2014;26:2030-9 pubmed publisher
    ..The transmembrane prostate androgen-induced protein (TMEPAI) is elevated in several cancers...
  38. Sharad S, Ravindranath L, Haffner M, Li H, Yan W, Sesterhenn I, et al. Methylation of the PMEPA1 gene, a negative regulator of the androgen receptor in prostate cancer. Epigenetics. 2014;9:918-27 pubmed publisher
    The prostate transmembrane protein androgen induced 1 (PMEPA1) gene is highly expressed in prostate epithelial cells and is a direct transcriptional target for the androgen receptor (AR)...
  39. Hu Y, He K, Wang D, Yuan X, Liu Y, Ji H, et al. TMEPAI regulates EMT in lung cancer cells by modulating the ROS and IRS-1 signaling pathways. Carcinogenesis. 2013;34:1764-72 pubmed publisher
    ..the biological function and the signaling pathway of prostate transmembrane protein, androgen induced-1 (TMEPAI), during the induction of EMT and cell migration...
  40. Aslibekyan S, An P, Frazier Wood A, Kabagambe E, Irvin M, Straka R, et al. Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. Nutr Metab Cardiovasc Dis. 2013;23:987-94 pubmed publisher
    ..Our findings provide support for fine-mapping of the 12q24 region to investigate the shared biological mechanisms underlying levels of circulating adiponectin and susceptibility to metabolic disease. ..
  41. Liu R, Zhou Z, Huang J, Chen C. PMEPA1 promotes androgen receptor-negative prostate cell proliferation through suppressing the Smad3/4-c-Myc-p21 Cip1 signaling pathway. J Pathol. 2011;223:683-94 pubmed publisher
    The PMEPA1 gene has been shown to suppress the androgen receptor (AR) and TGF? signaling pathways and is abnormally expressed in prostate tumours. However, the role and mechanism action of PMEPA1 in AR-negative prostate cancer are unclear...
  42. Singha P, Yeh I, Venkatachalam M, Saikumar P. Transforming growth factor-beta (TGF-beta)-inducible gene TMEPAI converts TGF-beta from a tumor suppressor to a tumor promoter in breast cancer. Cancer Res. 2010;70:6377-83 pubmed publisher
    b>TMEPAI is a transforming growth factor-beta (TGF-beta)-induced transmembrane protein that is overexpressed in several cancers. How TMEPAI expression relates to malignancy is unknown...
  43. Feng S, Zhu X, Fan B, Xie D, Li T, Zhang X. miR?19a?3p targets PMEPA1 and induces prostate cancer cell proliferation, migration and invasion. Mol Med Rep. 2016;13:4030-8 pubmed publisher
    ..study investigated the biological impact and regulation of prostate transmembrane protein androgen induced 1 (PMEPA1) in PCa cells by transfection with PMEPA1 small interfering (si)RNA...
  44. Zou Y, Zhang Y, Wang T, Wang S, Yang A, Jia L, et al. [Transmembrane prostate androgen-induced protein 1 (PMEPA1) promotes the migration and maintains mesenchymal-like phenotype of breast cancer cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:158-62 pubmed
    To investigate the role of transmembrane prostate androgen-induced protein 1 (PMEPA1), an important gene downstream of transforming growth factor-β (TGF-β) signaling, in the process of breast cancer cell migration and epithelial-..
  45. Giannini G, Ambrosini M, Di Marcotullio L, Cerignoli F, Zani M, MacKay A, et al. EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer. Mol Carcinog. 2003;38:188-200 pubmed
    ..2, the mouse homolog of the solid tumor-associated gene STAG1. Both in humans and in mice, it belongs to a new gene family that can give origin to several protein isoforms ..
  46. Liu Z, Huo X, Zhao S, Yang J, Shi W, Jing L, et al. Low density lipoprotein receptor class A domain containing 4 (LDLRAD4) promotes tumorigenesis of hepatic cancer cells. Exp Cell Res. 2017;360:189-198 pubmed publisher
    ..The structure of LDLRAD4 protein is similar to that of TMEPAI protein, which is overexpressed in many tumors...
  47. Azami S, Vo Nguyen T, Watanabe Y, Kato M. Cooperative induction of transmembrane prostate androgen induced protein TMEPAI/PMEPA1 by transforming growth factor-β and epidermal growth factor signaling. Biochem Biophys Res Commun. 2015;456:580-5 pubmed publisher
    TMEPAI/PMEPA1 (transmembrane prostate androgen induced-RNA/prostate transmembrane protein, androgen induced 1) is a pro-tumorigenic factor induced by TGF-β signaling and constitutive TMEPAI expression in lung cancer cells depends on ..
  48. Li H, Xu L, Masuda K, Raymundo E, McLeod D, Dobi A, et al. A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells. J Biol Chem. 2008;283:28988-95 pubmed publisher
    b>PMEPA1 was identified originally as a highly androgen-inducible gene with prostate-abundant expression that was restricted to prostatic epithelial cells...
  49. Koido M, Sakurai J, Tsukahara S, Tani Y, Tomida A. PMEPA1, a TGF-?- and hypoxia-inducible gene that participates in hypoxic gene expression networks in solid tumors. Biochem Biophys Res Commun. 2016;479:615-621 pubmed publisher
    Prostate transmembrane protein, androgen induced 1 (PMEPA1) is highly expressed in various solid tumors and is known to play important roles in the transforming growth factor-? (TGF-?) signaling pathway...
  50. Xu L, Shanmugam N, Segawa T, Sesterhenn I, McLeod D, Moul J, et al. A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate. Genomics. 2000;66:257-63 pubmed
    ..The open reading frame of the androgen-induced RNA (PMEPA1) was characterized as a 759-bp nucleotide sequence coding for a 252-amino-acid protein...
  51. Jolliffe C, Harvey K, Haines B, Parasivam G, Kumar S. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Biochem J. 2000;351 Pt 3:557-65 pubmed
    ..These results provide evidence that Nedd4 can potentially interact with multiple proteins, possibly simultaneously, through its WW domains. ..
  52. Link A, Kurinna S, Havlicek S, Lehnert S, Reichel M, Kornhuber J, et al. Kdm6b and Pmepa1 as Targets of Bioelectrically and Behaviorally Induced Activin A Signaling. Mol Neurobiol. 2016;53:4210-4225 pubmed publisher
    ..that binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-β signaling in cancer cells, and at the Kdm6b gene, ..
  53. Richter E, Masuda K, Cook C, Ehrich M, Tadese A, Li H, et al. A role for DNA methylation in regulating the growth suppressor PMEPA1 gene in prostate cancer. Epigenetics. 2007;2:100-9 pubmed
    ..b>PMEPA1 gene is an androgen-inducible negative regulator of cell growth in the prostate epithelium...
  54. Hirokawa Y, Takagi A, Uchida K, Kozuka Y, Yoneda M, Watanabe M, et al. High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone. Cell Mol Biol Lett. 2007;12:370-7 pubmed publisher
    ..Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.
  55. Rae F, Hooper J, Nicol D, Clements J. Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors. Mol Carcinog. 2001;32:44-53 pubmed
    ..The full-length cDNA (4839 bp) encompassed the recently reported androgen-regulated prostatic cDNA PMEPA1, and so we refer to this gene as STAG1/PMEPA1. Two STAG1/PMEPA1 mRNA transcripts of approximately 2...