PMEL

Summary

Gene Symbol: PMEL
Description: premelanosome protein
Alias: D12S53E, ME20, ME20-M, ME20M, P100, PMEL17, SIL, SILV, gp100, melanocyte protein PMEL, melanocyte protein Pmel 17, melanocyte protein mel 17, melanocytes lineage-specific antigen GP100, melanoma-associated ME20 antigen, melanosomal matrix protein17, silver locus protein homolog, silver, mouse, homolog of
Species: human
Products:     PMEL

Top Publications

  1. Maresh G, Wang W, Beam K, Malacko A, Hellstrom I, Hellstrom K, et al. Differential processing and secretion of the melanoma-associated ME20 antigen. Arch Biochem Biophys. 1994;311:95-102 pubmed
    A murine monoclonal antibody, ME20, with high selectivity for melanomas, has been utilized to isolate a unique membrane-bound (designated ME20-M) and secreted (designated ME20-S) antigen from H3606 human melanoma cells...
  2. Berson J, Harper D, Tenza D, Raposo G, Marks M. Pmel17 initiates premelanosome morphogenesis within multivesicular bodies. Mol Biol Cell. 2001;12:3451-64 pubmed
    ..The melanocyte-specific glycoprotein Pmel17 is enriched in the lumen of premelanosomes, where it associates with characteristic striations of unknown ..
  3. Valencia J, Rouzaud F, Julien S, Chen K, Passeron T, Yamaguchi Y, et al. Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils. J Biol Chem. 2007;282:11266-80 pubmed
    b>Pmel17 is a melanocyte/melanoma-specific protein that is essential for the maturation of melanosomes to form mature, fibrillar, and pigmented organelles...
  4. Leonhardt R, Vigneron N, Rahner C, Cresswell P. Proprotein convertases process Pmel17 during secretion. J Biol Chem. 2011;286:9321-37 pubmed publisher
    b>Pmel17 is a melanocyte/melanoma-specific protein that traffics to melanosomes where it forms a fibrillar matrix on which melanin gets deposited...
  5. Raposo G, Tenza D, Murphy D, Berson J, Marks M. Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells. J Cell Biol. 2001;152:809-24 pubmed
    ..Melanosome resident proteins Pmel17 and TRP1 localized to separate vesicular structures that were distinct from those enriched in lysosomal proteins...
  6. Nichols S, Harper D, Berson J, Marks M. A novel splice variant of Pmel17 expressed by human melanocytes and melanoma cells lacking some of the internal repeats. J Invest Dermatol. 2003;121:821-30 pubmed
    b>Pmel17 is a approximately 100 kDa pigment cell specific glycoprotein that plays a crucial part in the morphogenesis of melanosome precursors...
  7. Yasumoto K, Watabe H, Valencia J, Kushimoto T, Kobayashi T, Appella E, et al. Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment. J Biol Chem. 2004;279:28330-8 pubmed
    ..This depends upon the trafficking and processing of gp100 (also known as Pmel17 and the silver protein), a protein of great interest, because it elicits immune responses in melanoma patients but ..
  8. Valencia J, Watabe H, Chi A, Rouzaud F, Chen K, Vieira W, et al. Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2: evidence for the polarized nature of melanocytes. J Cell Sci. 2006;119:1080-91 pubmed
    ..from the trans-Golgi network, but how they function in the sorting of various melanosome-specific proteins such as Pmel17, an essential structural component of melanosomes, in melanocytes is unknown...
  9. Theos A, Truschel S, Tenza D, Hurbain I, Harper D, Berson J, et al. A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis. Dev Cell. 2006;10:343-54 pubmed
    ..We show that the melanosomal protein Pmel17 is sorted into ILVs by a mechanism that is dependent upon lumenal determinants and conserved in non-pigment cells...

More Information

Publications111 found, 100 shown here

  1. Harper D, Theos A, Herman K, Tenza D, Raposo G, Marks M. Premelanosome amyloid-like fibrils are composed of only golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes. J Biol Chem. 2008;283:2307-22 pubmed
    ..The fibrils consist of proteolytic fragments derived from Pmel17, a pigment cell-specific integral membrane protein...
  2. McGlinchey R, Shewmaker F, McPhie P, Monterroso B, Thurber K, Wickner R. The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis. Proc Natl Acad Sci U S A. 2009;106:13731-6 pubmed publisher
    b>Pmel17 is a melanocyte protein necessary for eumelanin deposition 1 in mammals and found in melanosomes in a filamentous form. The luminal part of human Pmel17 includes a region (RPT) with 10 copies of a partial repeat sequence, pt.e.gttp...
  3. WATT B, van Niel G, Fowler D, Hurbain I, Luk K, Stayrook S, et al. N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. J Biol Chem. 2009;284:35543-55 pubmed publisher
    b>Pmel17 is a transmembrane protein that mediates the early steps in the formation of melanosomes, the subcellular organelles of melanocytes in which melanin pigments are synthesized and stored...
  4. Hoashi T, Tamaki K, Hearing V. The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding. FASEB J. 2010;24:916-30 pubmed publisher
    Ectodomain shedding is a proteolytic mechanism by which a transmembrane protein is converted into a secreted form. Pmel17/gp100 is a melanocyte-specific membrane-bound glycoprotein that has amyloid characteristics and forms fibrillar ..
  5. Leonhardt R, Vigneron N, Rahner C, van den Eynde B, Cresswell P. Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction. J Biol Chem. 2010;285:16166-83 pubmed publisher
    b>Pmel17 is a melanocyte/melanoma-specific protein that subcellularly localizes to melanosomes, where it forms a fibrillar matrix that serves for the sequestration of potentially toxic reaction intermediates of melanin synthesis and ..
  6. WATT B, Tenza D, Lemmon M, Kerje S, Raposo G, Andersson L, et al. Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic. PLoS Genet. 2011;7:e1002286 pubmed publisher
    b>PMEL is a pigment cell-specific protein that forms physiological amyloid fibrils upon which melanins ultimately deposit in the lumen of the pigment organelle, the melanosome...
  7. Adema G, de Boer A, Vogel A, Loenen W, Figdor C. Molecular characterization of the melanocyte lineage-specific antigen gp100. J Biol Chem. 1994;269:20126-33 pubmed
    ..from the open reading frame present in gp100-c1 cDNA is highly homologous to another melanocyte-specific protein, Pmel17. Nucleotide sequence analysis of genomic DNA indicates that the transcripts corresponding to gp100 and Pmel17 ..
  8. Chakraborty A, Platt J, Kim K, Kwon B, Bennett D, Pawelek J. Polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin by the pmel 17/silver locus protein. Eur J Biochem. 1996;236:180-8 pubmed
    ..In addition, the activity was found with the mouse pmel 17/silver locus protein immunopurified from human melanoma cells, and was significantly reduced in extracts of ..
  9. Berson J, Theos A, Harper D, Tenza D, Raposo G, Marks M. Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis. J Cell Biol. 2003;161:521-33 pubmed
    ..The integral membrane protein Pmel17 is a component of the fibrils and can nucleate their formation in the absence of other pigment cell-specific ..
  10. Hoashi T, Muller J, Vieira W, Rouzaud F, Kikuchi K, Tamaki K, et al. The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers. J Biol Chem. 2006;281:21198-208 pubmed
    Over 125 pigmentation-related genes have been identified to date. Of those, PMEL17/GP100 has been widely studied as a melanoma-specific antigen as well as a protein required for the formation of fibrils in melanosomes...
  11. Theos A, Berson J, Theos S, Herman K, Harper D, Tenza D, et al. Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17. Mol Biol Cell. 2006;17:3598-612 pubmed
    b>Pmel17 is a pigment cell-specific integral membrane protein that participates in the formation of the intralumenal fibrils upon which melanins are deposited in melanosomes...
  12. Kummer M, Maruyama H, Huelsmann C, Baches S, Weggen S, Koo E. Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase. J Biol Chem. 2009;284:2296-306 pubmed publisher
    ..One exception is the nonpathological amyloid derived from the protein Pmel17 within melanosomes to generate melanin pigment...
  13. van Niel G, Charrin S, Simoes S, Romao M, Rochin L, Saftig P, et al. The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. Dev Cell. 2011;21:708-21 pubmed publisher
    ..b>PMEL-a component of melanocyte LROs (melanosomes)-is sorted to ILVs in an ESCRT-independent manner, where it is ..
  14. Yamaguchi Y, Hearing V. Physiological factors that regulate skin pigmentation. Biofactors. 2009;35:193-9 pubmed publisher
    ..The main structural component of melanosomes is Pmel17/gp100/Silv, whose sorting involves adaptor protein 1A (AP1A), AP1B, AP2, and spectrin, as well as a chaperone-like ..
  15. Al Brakati A, Fouda M, Tharwat A, Elmahallawy E, Kassab R, Abdel Moneim A. The protective efficacy of soursop fruit extract against hepatic injury associated with acetaminophen exposure is mediated through antioxidant, anti-inflammatory, and anti-apoptotic activities. Environ Sci Pollut Res Int. 2019;26:13539-13550 pubmed publisher
    ..albino rats were randomly divided into five groups as follows: control, SSFE, APAP, SSFE+APAP, and silymarin (SIL)+APAP...
  16. Akdoğan N, Alli N, Uysal P, Topçuoğlu C, Candar T, Turhan T. Visfatin and insulin levels and cigarette smoking are independent risk factors for hidradenitis suppurativa: a case-control study. Arch Dermatol Res. 2018;310:785-793 pubmed publisher
    ..Each unit increase in the SVL (P = 0.003, 95% CI 1.16-2.11) and SIL (P = 0.03, 95% CI 1.01-1.17) increased the risk of HS 1.56- and 1.09-fold, respectively...
  17. Lotti F, Maseroli E, Fralassi N, Degl Innocenti S, Boni L, Baldi E, et al. Is thyroid hormones evaluation of clinical value in the work-up of males of infertile couples?. Hum Reprod. 2016;31:518-29 pubmed publisher
    ..and transrectal colour-Doppler ultrasound (CDUS) and semen analysis (including seminal interleukin 8 levels, sIL-8) evaluation within the same day. Among the patients studied, 145 (88.9%) showed euthyroidism, 6 (3...
  18. Kawaguchi M, Hozumi Y, Suzuki T. ADAM protease inhibitors reduce melanogenesis by regulating PMEL17 processing in human melanocytes. J Dermatol Sci. 2015;78:133-42 pubmed publisher
    ..We therefore focused on the processing of PMEL17, a melanosomal glycoprotein that forms a fibrillar matrix on which melanin gets deposited...
  19. Iwagami M, Furuya R, Tsutsumi D, Mochida Y, Ishioka K, Oka M, et al. True identity of endocapillary proliferation: a case of intravascular large B cell lymphoma diagnosed with immunohistochemical study of kidney biopsy and literature review. CEN Case Rep. 2012;1:61-68 pubmed publisher
    ..47 to 0.66 mg/dl, and soluble interleukin-2 receptor (sIL-2R) from 1789 to 1001 U/ml. Thus, she was followed carefully as an outpatient...
  20. Pedersen J, Jiang Z, Christiansen G, Lee J, Pedersen J, Otzen D. Lysophospholipids induce fibrillation of the repeat domain of Pmel17 through intermediate core-shell structures. Biochim Biophys Acta Proteins Proteom. 2018;: pubmed publisher
    Lipids often play an important role in the initial steps of fibrillation. The melanosomal protein Pmel17 forms amyloid in vivo and contains a highly amyloidogenic Repeat domain (RPT), important for melanin biosynthesis...
  21. Tamura K, Ohbayashi N, Maruta Y, Kanno E, Itoh T, Fukuda M. Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes. Mol Biol Cell. 2009;20:2900-8 pubmed publisher
    ..reduction in Tyrp1 (tyrosinase-related protein 1) signals from melanosomes but did not cause any reduction in Pmel17 signals...
  22. Lotti F, Corona G, Vitale P, Maseroli E, Rossi M, Fino M, et al. Current smoking is associated with lower seminal vesicles and ejaculate volume, despite higher testosterone levels, in male subjects of infertile couples. Hum Reprod. 2015;30:590-602 pubmed publisher
    ..scrotal and transrectal colour-Doppler ultrasound and semen analysis (including seminal interleukin-8 levels, sIL-8) within the same day. Among the patients evaluated, 229 were never smokers (NS), 56 past smokers (PS) and 109 CS...
  23. Saad M, Rastanawi A, El Yamany M. Alogliptin abates memory injuries of hepatic encephalopathy induced by acute paracetamol intoxication via switching-off autophagy-related apoptosis. Life Sci. 2018;215:11-21 pubmed publisher
    ..Forty rats were divided into four groups as follows; Normal Control Group, APAP intoxicated group, ALO and SIL groups...
  24. Martinez Fierro M, Castruita De la Rosa C, Garza Veloz I, Cardiel Hernandez R, Espinoza Juarez M, Delgado Enciso I, et al. Early pregnancy protein multiplex screening reflects circulating and urinary divergences associated with the development of preeclampsia. Hypertens Pregnancy. 2018;37:37-50 pubmed publisher
    ..PRL), ANG-2, transforming growth factor alpha (TGF-?), and VEGF-A at 16 GW, and soluble IL-6 receptor alpha (sIL-6R?), ANG-2 and sFASL at 20 GW, were different between groups (p < 0.05)...
  25. Wong S, Sturm R, Michel J, Zhang X, Danoy P, McGregor K, et al. Transcriptional regulation of differentiation, selective toxicity and ATGCAAAT binding of bisbenzimidazole derivatives in human melanoma cells. Biochem Pharmacol. 1994;47:827-37 pubmed
    ..activity and tyrosinase mRNA but decreased the level of gp75 (TRP-1) mRNA; message for a third pigment gene, Pmel-17, was unchanged...
  26. Bergam P, Reisecker J, Rakvács Z, Kucsma N, Raposo G, Szakacs G, et al. ABCB6 Resides in Melanosomes and Regulates Early Steps of Melanogenesis Required for PMEL Amyloid Matrix Formation. J Mol Biol. 2018;430:3802-3818 pubmed publisher
    ..Depletion of ABCB6 by siRNA impaired PMEL amyloidogenesis in early melanosomes and induced aberrant accumulation of multilamellar aggregates in pigmented ..
  27. Petersen P, Lei X, Seldin M, Rodriguez S, Byerly M, Wolfe A, et al. Dynamic and extensive metabolic state-dependent regulation of cytokine expression and circulating levels. Am J Physiol Regul Integr Comp Physiol. 2014;307:R1458-70 pubmed publisher
    ..markedly increased granulocyte colony-stimulating factor (G-CSF), IL-1β, chemokine (C-C motif) ligand (CCL2), sIL-1RI, lipocalin-2, pentraxin-3, tissue inhibitor of metalloproteinase (TIMP-1), and serum amyloid protein (SAP) ..
  28. Burgoyne T, O Connor M, Seabra M, Cutler D, Futter C. Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL. J Cell Sci. 2015;128:1400-7 pubmed publisher
    ..We further show that PMEL, a key component of mammalian melanosome biogenesis, is required for the generation of cylindrical melanosomes in ..
  29. Schreibelt G, Bol K, Westdorp H, Wimmers F, Aarntzen E, Duiveman de Boer T, et al. Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells. Clin Cancer Res. 2016;22:2155-66 pubmed publisher
    ..activated by only brief (16 hours) ex vivo culture and loaded with tumor-associated antigens of tyrosinase and gp100. Our results show that therapeutic vaccination against melanoma with small amounts (3-10 × 10(6)) of myeloid DCs ..
  30. Baskaran K, Kumar P, Karunanithi S, Sethupathy S, Thamaraiselvi B, Swaruparani S. Detection of High-Risk Human Papillomaviruses in the Prevention of Cervical Cancer in India. Asian Pac J Cancer Prev. 2015;16:8187-90 pubmed
    ..7% of controls. The association of HPV infection with SIL and cervical cancer was analyzed with Chi square test (p<0.001)...
  31. Bol K, Aarntzen E, Pots J, Olde Nordkamp M, van de Rakt M, Scharenborg N, et al. Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity. Cancer Immunol Immunother. 2016;65:327-39 pubmed publisher
    ..injection (16 patients) with VAC-DC loaded with keyhole limpet hemocyanin (KLH) and mRNA encoding tumor antigens gp100 and tyrosinase...
  32. Audirac Chalifour A, Torres Poveda K, Bahena Román M, Tellez Sosa J, Martinez Barnetche J, Cortina Ceballos B, et al. Cervical Microbiome and Cytokine Profile at Various Stages of Cervical Cancer: A Pilot Study. PLoS ONE. 2016;11:e0153274 pubmed publisher
    ..difference in microbiota's diversity in NCL-HPV negative women vs those with squamous intraepithelial lesions (SIL) and CC(p = 0.006, p = 0.036)...
  33. Chee J, Ravins M, Hanski E, Chen S. Complete Genome Sequence of Streptococcus pyogenes emm14 JS95, a Necrotizing Fasciitis Strain Isolated in Israel. Genome Announc. 2017;5: pubmed publisher
    ..The streptococcal invasion locus (sil), the first quorum-sensing system characterized in S. pyogenes, was identified in this strain.
  34. Castillo Rodríguez E, Pizarro Sánchez S, Sanz A, Ramos A, Sanchez Nino M, Martín Cleary C, et al. Inflammatory Cytokines as Uremic Toxins: "Ni Son Todos Los Que Estan, Ni Estan Todos Los Que Son". Toxins (Basel). 2017;9: pubmed publisher
    ..cytokines, cytokine receptors and chemokines that may fulfill the criteria to be considered uremic toxins, such as sIL-6R, sTNFR1, sTNFR2, IL-2, CXCL12, CX3CL1 and others...
  35. Tu P, Li C, Lin W, Chen M, Su T, Bai Y. Structural and functional correlates of serum soluble IL-6 receptor level in patients with bipolar disorder. J Affect Disord. 2017;219:172-177 pubmed publisher
    ..Higher serum levels of soluble interleukin-6 receptor (sIL-6R), which forms a ligand-receptor complex with the potent proinflammatory cytokine IL-6, have been consistently ..
  36. Knörr F, Damm Welk C, Ruf S, Singh V, Zimmermann M, Reiter A, et al. Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Haematologica. 2018;103:477-485 pubmed publisher
    ..Pretreatment cytokine profiles in patients with anaplastic large cell lymphoma reflect a tumor signature as well as tumor burden and also differences in the strength of the patients' immune response. ..
  37. Nazari M, Bokhart M, Loziuk P, Muddiman D. Quantitative mass spectrometry imaging of glutathione in healthy and cancerous hen ovarian tissue sections by infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI). Analyst. 2018;143:654-661 pubmed publisher
    ..Subsequently, a series of calibration spots of stable isotope-labeled (SIL) GSH were pipetted on top of the tissue to construct a spatial calibration curve, and calculate the concentration ..
  38. Liu M, Xu G, Xue S, Zhong X, Chen G, Chen Z. Plasma levels of Th1/Th2 type cytokine are associated with change of prolactin and GH/IGF-I in hemodialysis patients. Int J Artif Organs. 2008;31:303-8 pubmed
    ..Baseline serum concentrations of GH/IGF-I, PRL, IL-2, sIL-2R, IFN-gamma, IL-4 and IL-10 were measured in all patients and control subjects...
  39. Thames A, Briones M, Magpantay L, Martinez Maza O, Singer E, Hinkin C, et al. The role of chemokine C-C motif ligand 2 genotype and cerebrospinal fluid chemokine C-C motif ligand 2 in neurocognition among HIV-infected patients. AIDS. 2015;29:1483-91 pubmed publisher
    ..IL-6, tumour necrosis factor-alpha (TNF-?), interferon-gamma (IFN-?), soluble tumor necrosis factor receptor 2, sIL-6R?, sIL-2, sCD14 and B-cell activating factor were quantified...
  40. Marchenko S, Soldatkin O, Kasap B, Kurc B, Soldatkin A, Dzyadevych S. Creatinine Deiminase Adsorption onto Silicalite-Modified pH-FET for Creation of New Creatinine-Sensitive Biosensor. Nanoscale Res Lett. 2016;11:173 pubmed publisher
    ..Additionally, the biosensor based on CD adsorbed on silicalite (Sil/CD) was characterized by high signal reproducibility (relative standard deviation (RSD) for creatinine measurement?=..
  41. Bushehri A, Chow E, Zhang L, Azad A, Vuong S, Pasetka M, et al. Urinary cytokines/chemokines pattern in patients with painful bone metastases undergoing external beam radiotherapy experiencing pain flare. Ann Palliat Med. 2016;5:107-15 pubmed publisher
    ..GRO, IL-4, IL-8, interferon gamma induced protein 10 (IP-10), MCP-1, macrophage derived chemokine (MDC), PDGF-AA, sIL-2Ra, TGF-Alpha, VEGF...
  42. Liu X, Fu G, Ji Z, Huang X, Ding C, Jiang H, et al. A Recombinant DNA Plasmid Encoding the sIL-4R-NAP Fusion Protein Suppress Airway Inflammation in an OVA-Induced Mouse Model of Asthma. Inflammation. 2016;39:1434-40 pubmed publisher
    ..The soluble IL-4 receptor (sIL-4R), which is the decoy receptor for Th2 cytokine IL-4, has been reported to be effective in treating asthma in ..
  43. Dempsey P. Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis. Biochim Biophys Acta Mol Cell Res. 2017;1864:2228-2239 pubmed publisher
    ..In addition, several signaling pathways that undergo ectodomain shedding by ADAM10 (e.g. Notch, EGFR/ErbB, IL-6/sIL-6R) help control intestinal injury/regenerative responses and may drive intestinal inflammation and colon cancer ..
  44. Huang R, Sun Y, Ho C, Liu K, Tang Q, Xie Y, et al. IL-6 potentiates BMP-2-induced osteogenesis and adipogenesis via two different BMPR1A-mediated pathways. Cell Death Dis. 2018;9:144 pubmed publisher
    ..In vitro data further show that IL-6 and its soluble receptor sIL-6R synergistically augment rhBMP-2-induced osteogenic and adipogenic differentiation of human BMSCs (hBMSCs) by ..
  45. Bateman A, Katundu K, Mwanahamuntu M, Kapambwe S, Sahasrabuddhe V, Hicks M, et al. The burden of cervical pre-cancer and cancer in HIV positive women in Zambia: a modeling study. BMC Cancer. 2015;15:541 pubmed publisher
    ..screened positive by DC, while 45 % had cytologic evidence of high grade squamous intraepithelial lesions (SIL) or worse...
  46. Wu S, Wang H, Wen Y, Liu W, Li P, Chiu C, et al. 4-(Phenylsulfanyl)butan-2-One Suppresses Melanin Synthesis and Melanosome Maturation In Vitro and In Vivo. Int J Mol Sci. 2015;16:20240-57 pubmed publisher
    ..factor (MITF), tyrosinase-related protein-1 (Trp-1), dopachrome tautomerase (DCT, Trp-2), and glycoprotein 100 (GP100). In an in vivo zebrafish model, it presented a remarkable suppression in melanogenesis after 48 h...
  47. Wanyoike Gichuhi J, Kayumba P, Khisa W. PREVALENCE OF CERVICAL CYTOLOGY ABNORMALITIES AMONG HIV INFECTED WOMEN AT RWANDA MILITARY HOSPITAL. East Afr Med J. 2014;91:333-40 pubmed
    ..Of the 293 women who were recruited for the study, cervical Squamous Intra epithelial Lesion (SIL) were present in 58 (20%). Of those with cervical SIL, 33 (56.89%) women had low-grade SIL, 15 (25...
  48. Boudewijns S, Westdorp H, Koornstra R, Aarntzen E, Schreibelt G, Creemers J, et al. Immune-related Adverse Events of Dendritic Cell Vaccination Correlate With Immunologic and Clinical Outcome in Stage III and IV Melanoma Patients. J Immunother. 2016;39:241-8 pubmed publisher
    ..vaccinated with monocyte-derived or naturally circulating autologous DCs loaded with tumor-associated antigens gp100 and tyrosinase. Median follow-up time was 54.3 months in stage III patients and 12.9 months in stage IV patients...
  49. McKay H, Bream J, Margolick J, Martinez Maza O, Phair J, Rinaldo C, et al. Host factors associated with serologic inflammatory markers assessed using multiplex assays. Cytokine. 2016;85:71-9 pubmed publisher
    ..CXCL13, IL-10, IL-12p70, IL-6, TNF-?, IL-2, IFN-?, IL-1?, GM-CSF, BAFF), and soluble immune receptors (sCD14, sIL-2R?, sCD27, sgp130, sTNF-R2) were measured longitudinally using multiplexed immunometric assays in 250 HIV-..
  50. Sülflow K, Schneider M, Loth T, Kascholke C, Schulz Siegmund M, Hacker M, et al. Melanocytes from the outer root sheath of human hair and epidermal melanocytes display improved melanotic features in the niche provided by cGEL, oligomer-cross-linked gelatin-based hydrogel. J Biomed Mater Res A. 2016;104:3115-3126 pubmed publisher
    ..not only a dramatic increase in melanin production but also a significant enhancement of melanotic gene PAX3, PMEL, TYR, and MITF expression in comparison to that of both CCC full-length collagen and PCL scaffolds, providing a ..
  51. Shiels M, Shu X, Chaturvedi A, Gao Y, Xiang Y, Cai Q, et al. A prospective study of immune and inflammation markers and risk of lung cancer among female never smokers in Shanghai. Carcinogenesis. 2017;38:1004-1010 pubmed publisher
    ..05). Soluble interleukin-6 receptor [sIL-6R; highest versus lowest category OR = 2.37; 95% confidence interval (CI) 1.40-4...
  52. Pao P, Emri E, Abdirahman S, Soorma T, Zeng H, Hauck S, et al. The effects of zinc supplementation on primary human retinal pigment epithelium. J Trace Elem Med Biol. 2018;49:184-191 pubmed publisher
    ..increasing the expression of Retinoid Isomerohydrolase (RPE65) gene; cell pigmentation; Premelanosome Protein (PMEL17) immunoreactivity; and secretion of proteins including Apolipoprotein E (APOE), Complement Factor H (CFH), and ..
  53. Falgenhauer L, Ghosh H, Guerra B, Yao Y, Fritzenwanker M, Fischer J, et al. Comparative genome analysis of IncHI2 VIM-1 carbapenemase-encoding plasmids of Escherichia coli and Salmonella enterica isolated from a livestock farm in Germany. Vet Microbiol. 2017;200:114-117 pubmed publisher
    ..as well as blaACC-1, strA/strB, and catA1 genes together with resistance to heavy metals (ter-, mer-, sil-, ars-, rcn-, and pco)...
  54. Ho T, WATT B, Spruce L, Seeholzer S, Marks M. The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation. J Biol Chem. 2016;291:3595-612 pubmed publisher
    ..Premelanosome protein (PMEL) forms non-toxic functional amyloid fibrils that assemble into sheets upon which melanins ultimately are deposited ..
  55. Aziz N, Detels R, Quint J, Li Q, Gjertson D, Butch A. Stability of cytokines, chemokines and soluble activation markers in unprocessed blood stored under different conditions. Cytokine. 2016;84:17-24 pubmed publisher
    ..Statistically significant changes were determined using the generalized estimating equation. IFN-?, sIL-2R?, sTNF-RII and ?2-microglobulin were stable in unprocessed serum, EDTA and heparinized blood samples stored at ..
  56. Shao W, Liu J, Yang K, Liang Y, Weng Y, Li S, et al. Hydrogen-bond interaction assisted branched copolymer HILIC material for separation and N-glycopeptides enrichment. Talanta. 2016;158:361-367 pubmed publisher
    ..In this work, branched copolymer modified hydrophilic material Sil@Poly(THMA-co-MBAAm), with high hydrophilicity and unique "claw-like" polyhydric groups, were prepared by "grafting ..
  57. Sun L, Sun J, Huo X, Li Y, Li Y, Xie X, et al. [Toll-like receptor 4 activation inhibits melanogenesis in melanocytes]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:1466-1470 pubmed
    ..real-time PCR and Western blotting were employed to determine the expression levels of pre-melanosomal protein (Pmel17), tyrosinase (TYR) and microphthalmia-associated transcription factor (MITF)...
  58. Gong Q, Li X, Gong Q, Zhu W, Song G, Lu Y. Hashimoto's thyroiditis could be secondary to vitiligo: the possibility of antigen crossover and oxidative stress between the two diseases. Arch Dermatol Res. 2016;308:277-81 pubmed publisher
    ..of HT without vitiligo, as well as normal thyroid tissues, were both negative for the expression of NKI/beteb, gp100, tyrosinase-related protein 1 (TRP1), HMB-45 and S100, whereas they were positive for the expression of tyrosinase-..
  59. Wang F, Tang M, Su S, Horng T. Wrist Pulse Rate Monitor Using Self-Injection-Locked Radar Technology. Biosensors (Basel). 2016;6: pubmed
    ..detected the respiratory rates and heart rates of a subject at a one-meter distance using a self-injection-locked (SIL) radar and a conventional continuous-wave (CW) radar to compare the sensitivity versus power consumption between ..
  60. Kielsen K, Shamim Z, Thiant S, Faucher S, Decker W, Christensen I, et al. Soluble Interleukin-7 receptor levels and risk of acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation. Clin Immunol. 2018;187:26-32 pubmed publisher
    ..IL-7 binds to cellular IL-7 receptors in competition with a soluble form of the receptor (sIL-7Rα). We hypothesized that altered sIL-7Rα levels may cause adverse outcomes in patients undergoing HSCT...
  61. Sütterlin S, Téllez Castillo C, Anselem L, Yin H, Bray J, Maiden M. Heavy Metal Susceptibility of Escherichia coli Isolated from Urine Samples from Sweden, Germany, and Spain. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..Two isolates also harbored the silver/copper resistance determinant pco/sil, and they belonged to sequence types ST10 (phylogroup A) and ST295 (phylogroup C)...
  62. Inoue Mochita M, Inoue T, Kojima S, Futakuchi A, Fujimoto T, Sato Ohira S, et al. Interleukin-6-mediated trans-signaling inhibits transforming growth factor-β signaling in trabecular meshwork cells. J Biol Chem. 2018;293:10975-10984 pubmed publisher
    ..Using a multiplex immunoassay, POAG patients decreased IL-6 levels and increased soluble IL-6 receptor (sIL-6R) levels compared with the controls...
  63. Kubota R, Wang Y, Minoshima S, Kudoh J, Mashima Y, Oguchi Y, et al. Mapping of the human gene for a melanocyte protein Pmel 17 (D12S53E) to chromosome 12q13-q14. Genomics. 1995;26:430-1 pubmed
  64. Lupetti R, Pisarra P, Verrecchia A, Farina C, Nicolini G, Anichini A, et al. Translation of a retained intron in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage. J Exp Med. 1998;188:1005-16 pubmed
    ..Instead, in these normal samples, both the spliced and the unspliced transcript of gp100 were expressed at high levels...
  65. Leonhardt R, Vigneron N, Hee J, Graham M, Cresswell P. Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils. Mol Biol Cell. 2013;24:964-81 pubmed publisher
    PMEL (also called Pmel17 or gp100) is a melanocyte/melanoma-specific glycoprotein that plays a critical role in melanosome development by forming a fibrillar amyloid matrix in the organelle for melanin deposition...
  66. Guo J, Xiang Y, Peng Y, Huang H, Lan Y, Wei Y. The association of novel IL-33 polymorphisms with sIL-33 and risk of systemic lupus erythematosus. Mol Immunol. 2016;77:1-7 pubmed publisher
    ..The gene polymorphism was measured using Snapshot SNP genotyping assays and confirmed by sequencing. Serum IL-33 (sIL-33) levels were measured by ELISA...
  67. Zhang S, Ji Z, Sun Z, Li M, Sheng C, Yue M, et al. Stable isotope labeling assisted liquid chromatography-tandem mass spectrometry for the analysis of perfluorinated carboxylic acids in serum samples. Talanta. 2017;166:255-261 pubmed publisher
    A new stable isotope labeling (SIL) reagent pair, 10-methyl-acridone-2-sulfonohydrazide (MASH) and its deuterated counterpart d3-MASH was synthesized and successfully applied to the analysis of perfluorinated carboxylic acids (..
  68. Baeeri M, Mohammadi Nejad S, Rahimifard M, Navaei Nigjeh M, Moeini Nodeh S, Khorasani R, et al. Molecular and biochemical evidence on the protective role of ellagic acid and silybin against oxidative stress-induced cellular aging. Mol Cell Biochem. 2018;441:21-33 pubmed publisher
    ..The aim of this study was to evaluate the anti-aging properties of ellagic acid (EA) and silybin (SIL), as natural antioxidant compounds on rat embryonic fibroblast (REF) cells...
  69. Swangphon P, Pientong C, Sunthamala N, Bumrungthai S, Azuma M, Kleebkaow P, et al. Correlation of Circulating CD64+/CD163+ Monocyte Ratio and stroma/peri-tumoral CD163+ Monocyte Density with Human Papillomavirus Infected Cervical Lesion Severity. Cancer Microenviron. 2017;10:77-85 pubmed publisher
    ..Circulating CD14+CD16+ and CD14+CD163+ monocytes were elevated in No-SIL and cervical lesions...
  70. Li J, Zhang S, Shao D, Yang Z, Zhang W. Effect of auxiliary group for p-type organic dyes in NiO-based dye-sensitized solar cells: The first principal study. Spectrochim Acta A Mol Biomol Spectrosc. 2018;193:192-196 pubmed publisher
    ..this paper, we designed three D-A-Ï€-A structured organic molecules based on the prototype dye QT-1, named ME18-ME20, and further investigated their electronic and optical properties with density functional theory (DFT) and time-..
  71. Aplan P, Lombardi D, Ginsberg A, Cossman J, Bertness V, Kirsch I. Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity. Science. 1990;250:1426-9 pubmed
    ..The fusion cDNA results from an interstitial deletion between a previously unknown locus, SIL (SCL interrupting locus), and the 5' untranslated region of SCL...
  72. Crocenzi F, Basiglio C, Pérez L, Portesio M, Pozzi E, Roma M. Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: possible involvement of cAMP. Biochem Pharmacol. 2005;69:1113-20 pubmed
    ..We aimed to assess the ability of silibinin (Sil), the silymarin active component, to prevent the retrieval of Bsep induced by TLC and E(2)17G, and the associated ..
  73. Arenberger P, Arenbergerova M, Gkalpakiotis S, Lippert J, Stribrna J, Kremen J. Multimarker real-time reverse transcription-PCR for quantitative detection of melanoma-associated antigens: a novel possible staging method. J Eur Acad Dermatol Venereol. 2008;22:56-64 pubmed publisher
    ..a multimarker real-time reverse transcription-PCR (RT-PCR) for quantification of five melanoma markers: Melan-A, gp100, MAGE-3, MIA and tyrosinase...
  74. Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Doi S, et al. Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nat Genet. 2011;43:893-6 pubmed publisher
    ..Our findings offer a better understanding of the genetic contribution to asthma susceptibility. ..
  75. Hieda J, Niinomi M, Nakai M, Kamura H, Tsutsumi H, Hanawa T. Improvement of adhesive strength of segmented polyurethane on Ti-29Nb-13Ta-4.6Zr alloy through H?O? treatment for biomedical applications. J Biomed Mater Res B Appl Biomater. 2013;101:776-83 pubmed publisher
    ..The shear bonding strength is doubled compared with the untreated TNTZ/SIL/SPU interface...
  76. Aparicio Siegmund S, Deseke M, Lickert A, Garbers C. Trans-signaling of interleukin-6 (IL-6) is mediated by the soluble IL-6 receptor, but not by soluble CD5. Biochem Biophys Res Commun. 2017;484:808-812 pubmed publisher
    ..IL-6 can further signal via soluble forms of its receptor (sIL-6R), a process that has been termed trans-signaling...
  77. Miralles M, Eixarch H, Tejero M, Costa C, Hirota K, Castaño A, et al. Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor. Neurotherapeutics. 2017;14:1095-1106 pubmed publisher
    ..Here, a soluble (s)IL-23R cDNA was cloned in expression plasmids and viral vectors. The clinical efficacy of sIL-23R was evaluated in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis mice ..
  78. Termini J, Gupta S, Raffa F, Guirado E, Fischl M, Niu L, et al. Epstein Barr virus Latent Membrane Protein-1 enhances dendritic cell therapy lymph node migration, activation, and IL-12 secretion. PLoS ONE. 2017;12:e0184915 pubmed publisher
    ..LMP1-transduced DC increased T cell proliferation in a Pmel-1 adoptive transfer model and enhanced survival in B16-F10 melanoma models...
  79. Traynor D, Kearney P, Ramos I, Martin C, O Leary J, Lyng F. A study of hormonal effects in cervical smear samples using Raman spectroscopy. J Biophotonics. 2017;: pubmed publisher
    ..cervical samples (45 cytology negative and 15 high grade dyskaryosis (high grade squamous intraepithelial lesion (SIL)) samples using a HORIBA Jobin Yvon XploRA™ system. HPV DNA testing was also performed...
  80. Handa T, Matsui S, Yoshifuji H, Kodama Y, Yamamoto H, Minamoto S, et al. Serum soluble interleukin-2 receptor as a biomarker in immunoglobulin G4-related disease. Mod Rheumatol. 2017;:1-21 pubmed publisher
    Serum soluble interleukin-2 (IL-2) receptor (sIL-2R) might reflect disease activity in immunoglobulin G4-related disease (IgG4-RD)...
  81. Wagner S, Wagner C, Schultewolter T, Goos M. Analysis of Pmel17/gp100 expression in primary human tissue specimens: implications for melanoma immuno- and gene-therapy. Cancer Immunol Immunother. 1997;44:239-47 pubmed
    b>Pmel17/gp100-encoded tumor-associated antigens are recognized by cytotoxic T lymphocytes in melanoma patients and may represent attractive target antigens for immuno- and gene-therapeutic strategies...
  82. Hoashi T, Watabe H, Muller J, Yamaguchi Y, Vieira W, Hearing V. MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes. J Biol Chem. 2005;280:14006-16 pubmed
    ..of other melanosomal proteins, such as tyrosinase, tyrosinase-related protein-1, dopachrome tautomerase, and Pmel17, are known, the function of MART-1 in melanogenesis, is unclear...
  83. Hutton S, Spritz R. Comprehensive analysis of oculocutaneous albinism among non-Hispanic caucasians shows that OCA1 is the most prevalent OCA type. J Invest Dermatol. 2008;128:2442-50 pubmed publisher
    ..TYRP1, SLC45A2), the two principal genes associated with syndromic OCA (HPS1, HPS4), and a candidate OCA gene (SILV), in 121 unrelated, unselected non-Hispanic/Latino Caucasian patients carrying the clinical diagnosis of OCA...
  84. Hu L, Sun L, Li Y, Li H, Liang D, Sun J, et al. [Detection of serum autoantibodies against premelanosome protein 17 increases in the vitiligo patients]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013;29:411-3, 417 pubmed
    To detect the distribution of autoantibodies against premelanosome protein 17 (Pmel 17) in the sera of vitiligo patients with the recombinant Pmel 17 protein...
  85. Jiang Z, Lee J. Lysophospholipid-containing membranes modulate the fibril formation of the repeat domain of a human functional amyloid, pmel17. J Mol Biol. 2014;426:4074-4086 pubmed publisher
    b>Pmel17 is an important protein for pigmentation in human skin and eyes. Proteolytic fragments from Pmel17 form fibrils upon which melanin is deposited in melanosomes...
  86. Choi R, Kim K, Kim M, Kim S, Kwon O, Jeon K, et al. Serum inflammatory profiles in pulmonary tuberculosis and their association with treatment response. J Proteomics. 2016;149:23-30 pubmed publisher
    ..Serum concentrations of eotaxin, MIP-1?, sIL-2R?, and lipocalin 2 were significantly different between pulmonary tuberculosis patients and controls (P<0.05)...
  87. Steinemann D, Zerz A, Adamina M, Brunner W, Keerl A, Nocito A, et al. Single-Incision and Natural Orifice Translumenal Endoscopic Surgery in Switzerland. World J Surg. 2017;41:449-456 pubmed publisher
    Single-incision laparoscopy (SIL) and natural orifice translumenal endoscopic surgery (NOTES) aim at reducing surgical access trauma...
  88. Slaney C, von Scheidt B, Davenport A, Beavis P, Westwood J, Mardiana S, et al. Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting. Clin Cancer Res. 2017;23:2478-2490 pubmed publisher
    ..dual-specific T cells expressing both a CAR specific for Her2 and a TCR specific for the melanocyte protein (gp100)...
  89. Song X, Xu C, Liu Z, Yue Z, Liu L, Yang T, et al. Comparative Transcriptome Analysis of Mink (Neovison vison) Skin Reveals the Key Genes Involved in the Melanogenesis of Black and White Coat Colour. Sci Rep. 2017;7:12461 pubmed publisher
    ..The expression levels of KITLG, LEF1, DCT, TYRP1, PMEL, Myo5a, Rab27a and SLC7A11 were validated by qRT-PCR, and the results were consistent with RNA-seq analysis...
  90. Gwinn W, Flake G, Bousquet R, Taylor G, Morgan D. Airway injury in an in vitro human epithelium-fibroblast model of diacetyl vapor exposure: diacetyl-induced basal/suprabasal spongiosis. Inhal Toxicol. 2017;29:310-321 pubmed publisher
    ..IL-1a, IL-6, IL-8, sIL-1Ra, TGFa, MCP-3 and TNFa proteins were increased following DA exposure of Epi/FT tissues; only IL-1a, IL-8, sIL-..
  91. Shain A, Kwok S, Folkins A, Kong C. Utility of p16 Immunohistochemistry in Evaluating Negative Cervical Biopsies Following High-risk Pap Test Results. Am J Surg Pathol. 2018;42:69-75 pubmed publisher
    ..The abnormalities corresponded to missed foci of HSIL (cervical intraepithelial neoplasia [CIN] 2) (n=1), SIL-indeterminate grade (n=7), atypical squamous metaplasia (n=2), and LSIL [CIN1]) (n=1)...
  92. Oeckl P, Steinacker P, Otto M. Comparison of internal standard approaches for SRM analysis of alpha-synuclein in cerebrospinal fluid. J Proteome Res. 2017;: pubmed publisher
    ..also MRM) is an alternative to immunoassays and the gold standard here is the addition of stable-isotope labeled (SIL) proteins (PSAQ)...