PLK2

Summary

Gene Symbol: PLK2
Description: polo like kinase 2
Alias: SNK, hPlk2, hSNK, serine/threonine-protein kinase PLK2, PLK-2, serine/threonine-protein kinase SNK, serum-inducible kinase
Species: human
Products:     PLK2

Top Publications

  1. Burns T, Fei P, Scata K, Dicker D, El Deiry W. Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells. Mol Cell Biol. 2003;23:5556-71 pubmed
    ..We have identified the Polo-like kinase family member serum inducible kinase (Snk/Plk2) as a novel p53 target gene...
  2. Mbefo M, Paleologou K, Boucharaba A, Oueslati A, Schell H, Fournier M, et al. Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem. 2010;285:2807-22 pubmed publisher
    ..Here we demonstrate that three closely related members of the human Polo-like kinase (PLK) family (PLK1, PLK2, and PLK3) phosphorylate alpha-syn and beta-syn specifically at Ser-129 and Ser-118, respectively...
  3. Hatzimichael E, Dasoula A, Benetatos L, Syed N, Dranitsaris G, Crook T, et al. Study of specific genetic and epigenetic variables in multiple myeloma. Leuk Lymphoma. 2010;51:2270-4 pubmed publisher
    ..and to examine whether there is any correlation between the methylation status of the CpG island of CDKN2A and Snk/Plk2 and MTHFR genotypes and with overall survival (OS) and other relevant clinical parameters...
  4. Cizmecioglu O, Krause A, Bahtz R, Ehret L, Malek N, Hoffmann I. Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4). J Cell Sci. 2012;125:981-92 pubmed publisher
    Polo-like kinases (Plks) perform crucial functions during mitosis, cytokinesis and centriole duplication. Plk2 is activated in early G1 phase and is involved in the reproduction of centrosomes...
  5. Fingas C, Mertens J, Razumilava N, Sydor S, Bronk S, Christensen J, et al. Polo-like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma. Hepatology. 2013;58:1362-74 pubmed publisher
    ..in CCA, revealing a pivotal role for the cell division regulating serine/threonine kinase polo-like kinase 2 (PLK2)...
  6. Valenti F, Fausti F, Biagioni F, Shay T, Fontemaggi G, Domany E, et al. Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop. Cell Cycle. 2011;10:4330-40 pubmed publisher
    ..documents the existence of an oncogenic auto-regulatory feedback loop that includes the Polo-like kinase-2 (Snk/Plk2) and mutant p53 proteins...
  7. Oueslati A, Schneider B, Aebischer P, Lashuel H. Polo-like kinase 2 regulates selective autophagic ?-synuclein clearance and suppresses its toxicity in vivo. Proc Natl Acad Sci U S A. 2013;110:E3945-54 pubmed publisher
    ..Here, we report that Polo-like kinase 2 (PLK2), an enzyme up-regulated in synucleinopathy-diseased brains, interacts with, phosphorylates and enhances ?-..
  8. Schwarz J, Schmidt S, Will O, Koudelka T, Köhler K, Boss M, et al. Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor ? ectodomain shedding. J Biol Chem. 2014;289:3080-93 pubmed publisher
    ..Here we report a direct interaction of the acidophilic kinase Polo-like kinase 2 (PLK2, also known as SNK) with the cytoplasmic portion of ADAM17 through the C-terminal noncatalytic region of PLK2 ..
  9. Cizmecioglu O, Warnke S, Arnold M, Duensing S, Hoffmann I. Plk2 regulated centriole duplication is dependent on its localization to the centrioles and a functional polo-box domain. Cell Cycle. 2008;7:3548-55 pubmed
    ..The polo-like kinase-2, Plk2, is activated near the G(1)/S phase transition, and plays an important role in the reproduction of centrosomes...

More Information

Publications104 found, 100 shown here

  1. Tan L, Chen K, Yuan Y, Liao P, Guo H. Identification of urine PLK2 as a marker of bladder tumors by proteomic analysis. World J Urol. 2010;28:117-22 pubmed publisher
    ..However, only PLK2 was identified with high confidence...
  2. Kristl J, Slanc P, Krasna M, Berlec A, Jeras M, Strukelj B. Calcipotriol affects keratinocyte proliferation by decreasing expression of early growth response-1 and polo-like kinase-2. Pharm Res. 2008;25:521-9 pubmed
    ..dowregulated the expression of two proliferation factors: early growth response-1 (EGR1) and polo-like kinase-2 (PLK2). The protein levels of EGR1 and PLK2 were also decreased...
  3. Inglis K, Chereau D, Brigham E, Chiou S, Schöbel S, Frigon N, et al. Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J Biol Chem. 2009;284:2598-602 pubmed publisher
    ..Here we submit evidence that polo-like kinase 2 (PLK2, also known as serum-inducible kinase or SNK) is a principle contributor to alpha-synuclein phosphorylation at Ser-..
  4. Krause A, Hoffmann I. Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication. PLoS ONE. 2010;5:e9849 pubmed publisher
    ..We previously reported that Polo-like kinase 2 (Plk2) is activated near the G1/S phase transition, and regulates the reproduction of centrosomes...
  5. Salvi M, Trashi E, Cozza G, Franchin C, Arrigoni G, Pinna L. Investigation on PLK2 and PLK3 substrate recognition. Biochim Biophys Acta. 2012;1824:1366-73 pubmed publisher
    ..kinases belonging to the Polo like kinase family have been characterized, with special reference to PLK1, PLK2, and PLK3 kinases...
  6. Ma S, Charron J, Erikson R. Role of Plk2 (Snk) in mouse development and cell proliferation. Mol Cell Biol. 2003;23:6936-43 pubmed
    b>Plk2 (Snk) is a polo-like kinase expressed at G(1) in cultured cells and mainly in the hippocampal neurons in the brains of adult rodents, but its function is poorly understood. We have generated mice deficient in Plk2 by gene targeting...
  7. Matsumoto T, Wang P, Ma W, Sung H, Matoba S, Hwang P. Polo-like kinases mediate cell survival in mitochondrial dysfunction. Proc Natl Acad Sci U S A. 2009;106:14542-6 pubmed publisher
    ..report that the targeted ablation of mitochondrial respiration markedly increases expression of Polo-like kinase 2 (PLK2) and that it is required for the in vitro growth of these nonrespiring cells...
  8. Matthew E, Hart L, Astrinidis A, Navaraj A, Dolloff N, Dicker D, et al. The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions. Cell Cycle. 2009;8:4168-75 pubmed
    ..We hypothesized that the p53 target gene, Plk2, is a tumor suppressor, mediating its tumor suppressor function through interactions with TSC1 that facilitate TSC1/..
  9. Salvi M, Trashi E, Marin O, Negro A, Sarno S, Pinna L. Superiority of PLK-2 as ?-synuclein phosphorylating agent relies on unique specificity determinants. Biochem Biophys Res Commun. 2012;418:156-60 pubmed publisher
    ..Here we provide biochemical evidence that PLK2 and to a lesser extent PLK3 are superior over CK2, as catalysts of Ser-129 phosphorylation both in full length ?-..
  10. Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, et al. The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. EMBO J. 1999;18:5528-39 pubmed
    ..Here we demonstrate that Fnk and Snk, two members of the polo family of cell cycle associated kinases, are co-opted by the brain to serve in this ..
  11. Warnke S, Kemmler S, Hames R, Tsai H, Hoffmann Rohrer U, Fry A, et al. Polo-like kinase-2 is required for centriole duplication in mammalian cells. Curr Biol. 2004;14:1200-7 pubmed
    ..Here we show that the human Polo-like kinase 2 (Plk2) is activated near the G1-to-S transition of the cell cycle...
  12. Syed N, Coley H, Sehouli J, Koensgen D, Mustea A, Szlosarek P, et al. Polo-like kinase Plk2 is an epigenetic determinant of chemosensitivity and clinical outcomes in ovarian cancer. Cancer Res. 2011;71:3317-27 pubmed publisher
    ..Here, we report that resistance can be conferred by downregulation of the Polo-like kinase Plk2. Mechanistic investigations revealed that downregulation occurred at the level of transcription via associated DNA ..
  13. Bhullar K, Jha A, Rupasinghe H. Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015;242:107-22 pubmed publisher
    ..Cell cycle essential aurora kinases (AURKα, AURKβ) and polo-like kinases (PLK1, PLK2, PLK3) were also modulated by CUR3d...
  14. Silva J, Ocarino N, Serakides R. Luteal activity of pregnant rats with hypo-and hyperthyroidism. J Ovarian Res. 2014;7:75 pubmed publisher
    ..The data were analyzed by SNK test. Hypothyroidism reduced COX-2 expression on day 10 and 19 (P < 0...
  15. Udhane S, Pandey A, Hofer G, Mullis P, Flück C. Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis. Sci Rep. 2015;5:10132 pubmed publisher
    ..HSD3B2, HSD3B1, CYP21A2, RARB, ASS1, CFI, ASCL1 and ENC1 play a role in steroid and energy metabolism and ANGPTL1, PLK2, DUSP6, DUSP10 and FREM2 are involved in signal transduction...
  16. Smith P, Furon E, Wiltshire M, Campbell L, Feeney G, Snyder R, et al. ABCG2-associated resistance to Hoechst 33342 and topotecan in a murine cell model with constitutive expression of side population characteristics. Cytometry A. 2009;75:924-33 pubmed publisher
    ..capacity to cope with chronic stress including over-expression of Aldh1a1 and Mgst1, but under-expression of Plk2 and Nnt...
  17. Dyszkiewicz Konwińska M, Nawrocki M, Huang Y, Bryja A, Celichowski P, Jankowski M, et al. New Gene Markers for Metabolic Processes and Homeostasis in Porcine Buccal Pouch Mucosa during Cells Long Term-Cultivation-A Primary Culture Approach. Int J Mol Sci. 2018;19: pubmed publisher
    ..In results, we observed significant up-regulation of SCARB1, PTGS2, DUSP5, ITGB3, PLK2, CCL2, TGFB1, CCL8, RFC4, LYN, ETS1, REL, LIF, SPP1
  18. Gumus M, Ozgur A, Tutar L, Dişli A, Koca I, Tutar Y. Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis. Curr Pharm Biotechnol. 2016;17:1231-1245 pubmed
    ..The compound inhibits expression of both Hsp90 isoforms and key proteins (cell cycle receptors; PLK2 and TERT, kinases; PI3KC3 and PRKCE, and growth factors; IGF1, IGF2, KDR, and PDGFRA) on oncogenic pathways...
  19. Castilhos L, Rezer J, Ruchel J, Thorstenberg M, Jaques J, Schlemmer J, et al. Effect of Uncaria tomentosa extract on purinergic enzyme activities in lymphocytes of rats submitted to experimental adjuvant arthritis model. BMC Complement Altern Med. 2015;15:189 pubmed publisher
    ..Data were analyzed by a one- or two-way ANOVA. Post hoc analyses were carried out by the Student-Newman-Keuls (SNK) Multiple Comparison Test. E-NTPDase activity was increased in arthritic untreated. Arthritic rats which received U...
  20. Olbryt M, Rusin A, Fokt I, Habryka A, Tudrej P, Student S, et al. Bis-anthracycline WP760 abrogates melanoma cell growth by transcription inhibition, p53 activation and IGF1R downregulation. Invest New Drugs. 2017;35:545-555 pubmed publisher
    ..Furthermore, WP760 downregulated IGF1R and upregulated PLK2 expression in most of the tested melanoma cell lines...
  21. Kim S, Kim J, Ki C, Ko Y, Kim J, Kim W. Epstein-Barr virus reactivation in extranodal natural killer/T-cell lymphoma patients: a previously unrecognized serious adverse event in a pilot study with romidepsin. Ann Oncol. 2016;27:508-13 pubmed publisher
    ..An in vitro study with the ENKTL cell line SNK-6 cells also showed that HDAC inhibitors including romidepsin increased the copy number of EBV DNA in a dose-..
  22. Helmke C, Becker S, Strebhardt K. The role of Plk3 in oncogenesis. Oncogene. 2016;35:135-47 pubmed publisher
    ..ATP-competitive inhibitors of Plk1 that are currently in clinical development also inhibit the activities of Plk2 and Plk3, which are considered as tumor suppressors...
  23. Qi X, Zhang Y, Pan J, Ma L, Wang L, Wang J. Effect of Bone Cement Implantation on Haemodynamics in Elderly Patients and Preventive Measure in Cemented Hemiarthroplasty. Biomed Res Int. 2015;2015:568019 pubmed publisher
    ..Analysis of variance and SNK-q test were used for the statistical analysis...
  24. Rad S, Arya A, Karimian H, Madhavan P, Rizwan F, Koshy S, et al. Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer's disease. Drug Des Devel Ther. 2018;12:3999-4021 pubmed publisher
    ..the formation of neurotoxic Aβ and NFTs via various mechanisms, including GSK3β, JNK, CamKII, CDK5, CK1, MARK4, PLK2, Syk, DYRK1A, PPP, and P70S6K...
  25. Goroshchuk O, Kolosenko I, Vidarsdottir L, Azimi A, Palm Apergi C. Polo-like kinases and acute leukemia. Oncogene. 2019;38:1-16 pubmed publisher
    ..In contrast, Plk2 and Plk3 are considered to be tumor suppressors...
  26. Pezuk J, Brassesco M, de Oliveira R, Machado H, Neder L, Scrideli C, et al. PLK1-associated microRNAs are correlated with pediatric medulloblastoma prognosis. Childs Nerv Syst. 2017;33:609-615 pubmed publisher
    ..clinico-pathological features, when comparing primary tumors to those relapsed, we found a consistent decrease on PLK2, miR-219, and miR-598* and an increase on miR-100 and miR-126...
  27. Fu X, Zhang X, Gao J, Li X, Zhang L, Li L, et al. Phosphatase and tensin homolog (PTEN) is down-regulated in human NK/T-cell lymphoma and corrects with clinical outcomes. Medicine (Baltimore). 2017;96:e7111 pubmed publisher
    ..of PTEN contributed to chemotherapy sensitivity to different doses of cisplatin (DDP) in human NK/T-cell lymphoma SNK-6 cells...
  28. Lin T, Min H, Jiang C, Niu M, Yan F, Xu L, et al. Design, synthesis and biological evaluation of phosphopeptides as Polo-like kinase 1 Polo-box domain inhibitors. Bioorg Med Chem. 2018;26:3429-3437 pubmed publisher
    ..44 μM) and nearly no binding to Plk2 PBD...
  29. Xu J, Hu S, Shen G, Shen G. Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy. Cancer Cell Int. 2016;16:13 pubmed publisher
    ..22 TSGs involved in PTX resistance, including BRCA1, TP53, PTEN, APC, CDKN1A, CDKN2A, HIN-1, RASSF1, YAP, ING4, PLK2, FBW7, BLU, LZTS1, REST, FADD, PDCD4, TGFBI, ING1, Bax, PinX1 and hEx...
  30. Visanji N, Wislet Gendebien S, Oschipok L, Zhang G, Aubert I, Fraser P, et al. Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes. J Biol Chem. 2011;286:35863-73 pubmed publisher
    ..of Ser(P)-129 or proteasome inhibitor-induced elevation in Ser(P)-129; or by inhibition or stable overexpression of PLK2), PD mutant Ser(P)-129 α-syn showed a preferential membrane association compared with WT Ser(P)-129 α-syn...
  31. Weng F, Garcia R, Lutzu S, Alviña K, Zhang Y, Dushko M, et al. Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation. Neuron. 2018;97:1137-1152.e5 pubmed publisher
    ..We further show that Npas4 regulates MF-CA3 synapses by controlling the expression of the polo-like kinase Plk2. Thus, Npas4 is a critical regulator of experience-dependent, structural, and functional plasticity at MF-CA3 ..
  32. Shimizu Yoshida Y, Sugiyama K, Rogounovitch T, Ohtsuru A, Namba H, Saenko V, et al. Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells. Biochem Biophys Res Commun. 2001;289:491-8 pubmed
    We identified a species relevant to polo-like kinase family, a human homologue of mouse serum-inducible kinase, hSNK gene, whose mRNA expression was rapidly increased in cultured human thyroid cells after X-ray irradiation...
  33. Hu Z, Liao X, Xu Z, Yang X, Dong C, Jin A, et al. PLK2 phosphorylates and inhibits enriched TAp73 in human osteosarcoma cells. Cancer Med. 2016;5:74-87 pubmed publisher
    ..Polo-like kinase 2 (PLK2) plays an important role in bone development...
  34. Kovakenko L, Kuznetsova O, Tallerova A, Nikitin S, Durnev A. Effect of 2-Isobutyl-4,6-dimethyl-5-hydroxypyrimidine on the Growth of Lewis Lung Carcinoma and Survival of Mice. Bull Exp Biol Med. 2016;161:99-103 pubmed publisher
    ..lung epidermoid carcinoma were performed to evaluate the effect of early or delayed administration of compound SNK-411 (2-isobutyl-4,6-dimethyl-5-hydroxypyrimidine) on tumor growth and animal survival...
  35. Qiu Y, Zhang G, Wan J, Zhao X. [Influence of covering of auto-crosslinked sodium hyaluronate gel in combination with xenogenic acellular dermal matrix on healing of full-thickness skin defect wound in pig]. Zhonghua Shao Shang Za Zhi. 2016;32:555-9 pubmed publisher
    ..Data were processed with one-way analysis of variance and SNK test...
  36. Bi X, Wang H, Zhang W, Wang J, Liu W, Xia Z, et al. PD-L1 is upregulated by EBV-driven LMP1 through NF-?B pathway and correlates with poor prognosis in natural killer/T-cell lymphoma. J Hematol Oncol. 2016;9:109 pubmed
    ..Expression of PD-L1 was measured in NK-92 (EBV-negative) and SNK-6 (EBV-positive) cells by western blot, quantitative real-time PCR and enzyme-linked immunosorbent assay, and flow ..
  37. Liu M, Wan L, Bin Y, Xiang J. Role of norepinephrine in A?-related neurotoxicity: dual interactions with Tyr10 and SNK(26-28) of A?. Acta Biochim Biophys Sin (Shanghai). 2017;49:170-178 pubmed publisher
    ..Tyr10 was identified as the strong binding site of NE, and SNK(26-28) segment was the weak binding segment...
  38. Lee Y, Lee J, Lee K, Turner R, HOE H, Pak D. Polo-like kinase 2 phosphorylation of amyloid precursor protein regulates activity-dependent amyloidogenic processing. Neuropharmacology. 2017;117:387-400 pubmed publisher
    ..However, mechanisms linking synaptic activity to APP processing are unclear. Here we show that Polo-like kinase 2 (Plk2), an activity-inducible regulator of homeostatic plasticity, directly binds and phosphorylates threonine-668 and ..
  39. Zhang X, Zhao L, Li X, Wang X, Li L, Fu X, et al. ATP-binding cassette sub-family C member 4 (ABCC4) is overexpressed in human NK/T-cell lymphoma and regulates chemotherapy sensitivity: Potential as a functional therapeutic target. Leuk Res. 2015;39:1448-54 pubmed publisher
    ..RNA sequencing to systematically screen for altered gene expression in human NK/T-cell lymphoma cell lines YTS and SNK-6 versus normal NK cells...
  40. Liu D, Zhuang M, Zhang J, Chen J, Sun B. [Study of exogenous carbon monoxide-releasing molecules 2 on endotoxin/lipopolysaccharide-induced abnormal activation of platelets of healthy human donors]. Zhonghua Shao Shang Za Zhi. 2015;31:354-60 pubmed
    ..Data were processed with one-way analysis of variance and SNK test...
  41. Wang Y, Zhang L, Lei R, Shen Y, Shen H, Wu Z, et al. [Effects of blocking two sites of transforming growth factor-β/Smads signaling on the formation of scar-related proteins in human skin fibroblasts]. Zhonghua Shao Shang Za Zhi. 2015;31:372-7 pubmed
    ..Data were processed with one-way analysis of variance and SNK-(q test)...
  42. Huang Z, Meng C, Chen J, Chen Y, Chen Y, Zhou T, et al. [Efficacy of fenofibrate for hepatic steatosis in rats after severe burn]. Zhonghua Shao Shang Za Zhi. 2016;32:277-82 pubmed publisher
    ..Measurement data were processed with analysis of variance of factorial design and SNK test, and enumeration data were processed with Kruskal-Wallis test and Nemenyi test...
  43. Kim T, Mehta S, Kaimal B, Lyons K, Dempsey R, Vemuganti R. Poststroke Induction of ?-Synuclein Mediates Ischemic Brain Damage. J Neurosci. 2016;36:7055-65 pubmed publisher
    ..Furthermore, knock-out mice that lack PLK2 (the predominant kinase that mediates S129 phosphorylation) showed better functional recovery and smaller infarcts ..
  44. Liu Y, Li Y, Wang Y. [Protective effect of Saccharomyces boulardii against intestinal mucosal barrier injury in rats with nonalcoholic fatty liver disease]. Zhonghua Gan Zang Bing Za Zhi. 2016;24:921-926 pubmed publisher
    ..A one-way analysis of variance and the SNK test were used for comparison between multiple groups, and the rank sum test was used as the non-parametric test...
  45. Tian Y, Fu S, Qiu G, Xu Z, Liu N, Zhang X, et al. MicroRNA-27a promotes proliferation and suppresses apoptosis by targeting PLK2 in laryngeal carcinoma. BMC Cancer. 2014;14:678 pubmed publisher
    ..In silico database analysis result revealed that PLK2 is a potential target of miR-27a...
  46. Sui H, Zhan L, Niu X, Liang L, Li X. The SNK and SPAR signaling pathway changes in hippocampal neurons treated with amyloid-beta peptide in vitro. Neuropeptides. 2017;63:43-48 pubmed publisher
    ..Serum-inducible kinase (SNK) is an activity-inducible member of the polo-like family of serine/threonine kinases...
  47. Kuznetsova O, Tallerova A, Nikitin S, Kovalenko L. Effects of 5-Pyrimidinol Derivative SNK-41 on Cytokine Profile of Mice with Lewis Lung Carcinoma. Bull Exp Biol Med. 2016;160:483-5 pubmed publisher
    We studied the effects of SNK-411, a new 5-pyrimidinol derivative, on serum cytokine profile of C57Bl/6 mice with Lewis lung carcinoma. The compound was injected intraperitoneally in doses of 25 and 50 mg/kg. A significant (by 3...
  48. Zou H, Yang P, Huang T, Zheng X, Xu G. PLK2 Plays an Essential Role in High D-Glucose-Induced Apoptosis, ROS Generation and Inflammation in Podocytes. Sci Rep. 2017;7:4261 pubmed publisher
    ..We identified 338 genes altered in diabetes-induced DKD glomeruli, and PLK2 exhibited the most dramatic change...
  49. Martin E, Messenger K, Sheats M, Jones S. Misoprostol Inhibits Lipopolysaccharide-Induced Pro-inflammatory Cytokine Production by Equine Leukocytes. Front Vet Sci. 2017;4:160 pubmed publisher
    ..were determined using one-way RM ANOVA (Holm-Sidak post hoc testing) or Friedman's RM ANOVA on Ranks (SNK post hoc testing), where appropriate (p?<?0.05, n?=?3-6 horses)...
  50. Zou H, Yang P, Huang T, Zheng X, Xu G. Author Correction: PLK2 Plays an Essential Role in High D-Glucose-Induced Apoptosis, ROS Generation and Inflammation in Podocytes. Sci Rep. 2018;8:4237 pubmed publisher
    ..A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ..
  51. Li F, Cong T, Li Z, Zhao L. [Effects of zinc deficiency on the relevant immune function in rats with sepsis induced by endotoxin/lipopolysaccharide]. Zhonghua Shao Shang Za Zhi. 2015;31:361-6 pubmed
    ..Data were processed with one-way analysis of variance and SNK test...
  52. Chamcheu J, Adhami V, Esnault S, Sechi M, Siddiqui I, Satyshur K, et al. Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice. Antioxid Redox Signal. 2017;26:49-69 pubmed publisher
    ..that Del binds to three lipid (PIK3CG, PIK3C2B, and PIK3CA) and six serine/threonine (PIM1, PIM3, mTOR, S6K1, PLK2, and AURKB) kinases, five of which belong to the PI3K/Akt/mTOR pathway...
  53. Annousaki O, Zinelis S, Eliades G, Eliades T. Comparative analysis of the mechanical properties of fiber and stainless steel multistranded wires used for lingual fixed retention. Dent Mater. 2017;33:e205-e211 pubmed publisher
    ..of tensile testing and IIT were statistically analyzed employing one way Anova and the Student Newman Keuls test (SNK) at a=0.05 level of significance...
  54. Zhou J, Zhang C, Sui X, Cao S, Tang F, Sun S, et al. Histone deacetylase inhibitor chidamide induces growth inhibition and apoptosis in NK/T lymphoma cells through ATM-Chk2-p53-p21 signalling pathway. Invest New Drugs. 2018;36:571-580 pubmed publisher
    ..SNT-8 and SNK-10 NKTCL cell lines were exposed to different concentrations of chidamide for the indicated time...
  55. Davis D, Jiang S. Usability testing of existing type 2 diabetes mellitus websites. Int J Med Inform. 2016;92:62-72 pubmed publisher
    ..The ANOVA tests revealed a significant difference for all three variables. The Student-Newman-Keuls (SNK) test shows a significant difference for completion time between American Diabetes Association and WebMD...
  56. Deng S, Wang H, Jia C, Zhu S, Chu X, Ma Q, et al. MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression. Arterioscler Thromb Vasc Biol. 2017;37:280-290 pubmed publisher
    ..The aim of this study was to characterize the role of the miR-146a-Polo-like kinase 2 (Plk2) network in regulating lin- BMC senescence, apoptosis, and their angiogenic capability...
  57. Sui X, Zhang C, Zhou J, Cao S, Xu C, Tang F, et al. Resveratrol inhibits Extranodal NK/T cell lymphoma through activation of DNA damage response pathway. J Exp Clin Cancer Res. 2017;36:133 pubmed publisher
    ..Here we report the anti-tumor effect of RSV in NKTCL cell lines SNT-8, SNK-10 and SNT-16...
  58. Park Y, Kim S, Kim Y, Kim S, Lee T, Lee I, et al. Polo-like kinase 2 gene expression is regulated by the orphan nuclear receptor estrogen receptor-related receptor gamma (ERRgamma). Biochem Biophys Res Commun. 2007;362:107-13 pubmed
    ..In the current study, we identify that Plk2 is a novel target of ERRgamma...
  59. Bufill E, Roura Poch P, Sala Matavera I, Antón S, Lleo A, Sánchez Saudinós B, et al. Reelin signaling pathway genotypes and Alzheimer disease in a Spanish population. Alzheimer Dis Assoc Disord. 2015;29:169-72 pubmed publisher
    ..A significant association between the genotypes RELN (rs528528 and rs2299356), PLK2 (rs15009 and rs702723), and CAMK2A (rs3756577 and rs3822606) and AD or MCI was found...
  60. Mochizuki M, Lorenz V, Ivanek R, Della Verde G, Gaudiello E, Marsano A, et al. Polo-Like Kinase 2 is Dynamically Regulated to Coordinate Proliferation and Early Lineage Specification Downstream of Yes-Associated Protein 1 in Cardiac Progenitor Cells. J Am Heart Assoc. 2017;6: pubmed publisher
    ..Among the most strongly regulated genes was polo-like kinase 2 (Plk2)...
  61. Liu L, Wang W, Zhao L, Guo B, Yang J, Zhao X, et al. Silencing of polo-like kinase 2 increases cell proliferation and decreases apoptosis in SGC-7901 gastric cancer cells. Mol Med Rep. 2015;11:3033-8 pubmed publisher
    Polo‑like kinase 2 (PLK2) is a serine/threonine protein kinase, which has vital roles during mitosis and the centrosome cycle...
  62. Íñigo Marco I, Valencia M, Larrea L, Bugallo R, Martínez Goikoetxea M, Zuriguel I, et al. E46K ?-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation. Proc Natl Acad Sci U S A. 2017;114:E8274-E8283 pubmed publisher
    ..While E46K induced robust PLK2-dependent aSyn phosphorylation at serine 129, inhibiting this phosphorylation did not alleviate aSyn toxicity, ..
  63. Pitzler L, Auler M, Probst K, Frie C, Bergmeier V, Holzer T, et al. miR-126-3p Promotes Matrix-Dependent Perivascular Cell Attachment, Migration and Intercellular Interaction. Stem Cells. 2016;34:1297-309 pubmed publisher
    ..Subsequent miRNA target analysis showed that miR-126-3p inhibits SPRED1 and PLK2 expression, induces ERK1/2 phosphorylation and stimulates TLR3 expression to modulate cell-cell and cell-matrix ..
  64. Holtrich U, Wolf G, Yuan J, Bereiter Hahn J, Karn T, Weiler M, et al. Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages. Oncogene. 2000;19:4832-9 pubmed
    ..Moreover, both proteins were shown to co-localize in mammalian cells. The homology of Cib with calmodulin and with calcineurin B suggests that Cib might be a regulatory subunit of polo-like kinases. ..
  65. Zhi W, Peng R, Li H, Zou Y, Yao B, Wang C, et al. Microwave radiation leading to shrinkage of dendritic spines in hippocampal neurons mediated by SNK-SPAR pathway. Brain Res. 2018;1679:134-143 pubmed publisher
    ..b>SNK-SPAR is a molecular pathway for neuronal homeostatic plasticity during chronically elevated activity...
  66. Liu P, Chen L. Inhibition of sonic hedgehog signaling blocks cell migration and growth but induces apoptosis via suppression of FOXQ1 in natural killer/T-cell lymphoma. Leuk Res. 2018;64:1-9 pubmed publisher
    ..Additionally, FOXQ1 expression in NKTCL cell lines (HANK-1, NK-92, SNK-6, SNT-8 and YT) was determined by western blotting and qRT-PCR...
  67. Rozeboom A, Pak D. Identification and functional characterization of polo-like kinase 2 autoregulatory sites. Neuroscience. 2012;202:147-57 pubmed publisher
    ..Here, we identified several novel Plk2 phosphorylation sites stimulated by Plk2 itself...
  68. Chang J, Cizmecioglu O, Hoffmann I, Rhee K. PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle. EMBO J. 2010;29:2395-406 pubmed publisher
    ..Here, we identified centrosomal P4.1-associated protein (CPAP), a human homologue of SAS-4, as a substrate of PLK2 whose activity oscillates during the cell cycle...
  69. Coley H, Hatzimichael E, Blagden S, McNeish I, Thompson A, Crook T, et al. Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer. Oncotarget. 2012;3:78-83 pubmed
    The polo-like kinase PLK2 has recently been identified as a potential theranostic marker in the management of chemotherapy sensitive cancers...
  70. Franchin C, Cesaro L, Pinna L, Arrigoni G, Salvi M. Identification of the PLK2-dependent phosphopeptidome by quantitative proteomics [corrected]. PLoS ONE. 2014;9:e111018 pubmed publisher
    Polo-like kinase 2 (PLK2) has been recently recognized as the major enzyme responsible for phosphorylation of α-synuclein at S129 in vitro and in vivo, suggesting that this kinase may play a key role in the pathogenesis of Parkinson's ..
  71. Ling H, Hanashiro K, Luong T, Benavides L, Fukasawa K. Functional relationship among PLK2, PLK4 and ROCK2 to induce centrosome amplification. Cell Cycle. 2015;14:544-53 pubmed publisher
    ..amplification in the cell cycle-arrested cells, including Rho-associated kinase (ROCK2), Polo-like kinase 2 (PLK2) and PLK4...
  72. Samuel F, Flavin W, Iqbal S, Pacelli C, Sri Renganathan S, Trudeau L, et al. Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization. J Biol Chem. 2016;291:4374-85 pubmed publisher
    ..Here, co-expression of α-syn and polo-like kinase 2 (PLK2), a kinase that targets Ser-129, was used to generate phosphorylated α-syn for biophysical and biological ..
  73. Liu F, Zhang S, Zhao Z, Mao X, Huang J, Wu Z, et al. MicroRNA-27b up-regulated by human papillomavirus 16 E7 promotes proliferation and suppresses apoptosis by targeting polo-like kinase2 in cervical cancer. Oncotarget. 2016;7:19666-79 pubmed publisher
    ..Dual-luciferase experiment confirmed miR-27b down-regulated its target gene PLK2 through the "seed regions"...
  74. Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W. The physical association and phosphorylation of Cdc25C protein phosphatase by Prk. Oncogene. 1999;18:6029-36 pubmed
    ..Together, these observations strongly suggest that Prk's role in mitosis is at least partly mediated through direct regulation of Cdc25C. ..
  75. Liby K, Wu H, Ouyang B, Wu S, Chen J, Dai W. Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase. DNA Seq. 2001;11:527-33 pubmed
    Murine serum inducible kinase (mSnk) was recently cloned and characterized as an early-growth response gene involved in cell proliferation. Here we report the isolation and characterization of its human homologue, named hSnk...
  76. Fan Q, Liu J, Zhang G, Wu H, Zhang R, Zhan S, et al. Inhibition of SNK-SPAR signaling pathway promotes the restoration of motor function in a rat model of ischemic stroke. J Cell Biochem. 2018;119:1093-1110 pubmed publisher
    ..Successfully established rat ischemic models were randomly divided into model, SNKMCAO-del and pcDNA3.1-SNK groups...
  77. Ren H, Li Y, Wang S, Han C. [Effects of endostatin pretreatment on fibrosis of human skin fibroblasts and the mechanisms]. Zhonghua Shao Shang Za Zhi. 2017;33:694-698 pubmed publisher
    ..Data were processed with one-way analysis of variance and SNK test. Results: (1) Compared with (5.05±0...
  78. FITZGERALD K, Bergeron M, Willits C, Bowers S, Aubele D, Goldbach E, et al. Pharmacological inhibition of polo like kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei. Toxicol Appl Pharmacol. 2013;269:1-7 pubmed publisher
    Polo like kinase 2 (PLK2) phosphorylates ?-synuclein and is considered a putative therapeutic target for Parkinson's disease...
  79. Kim J, Ku B, Lee K, Kim S. Structural analysis of the polo-box domain of human Polo-like kinase 2. Proteins. 2015;83:1201-8 pubmed publisher
    ..While Plk1 is a promising target for antitumor therapy, Plk2 is regarded as a tumor suppressor even though the two Plks commonly recognize the S-pS/T-P motif through their PBD...
  80. Rodríguez Nogales C, Garbayo E, Martinez Valbuena I, Sebastian V, Luquin M, Blanco Prieto M. Development and characterization of polo-like kinase 2 loaded nanoparticles-A novel strategy for (serine-129) phosphorylation of alpha-synuclein. Int J Pharm. 2016;514:142-149 pubmed publisher
    Polo like kinase 2 (PLK2), a serine/threonine serum inducible kinase, has been proposed to be the major factor responsible for phosphorylating alpha-synuclein (?-syn) at Serine-129 (Ser-129) in Parkinson's disease (PD)...
  81. Zhan M, Yang Y, Luo J, Zhang X, Xiao X, Li S, et al. Design, synthesis, and biological evaluation of novel highly selective polo-like kinase 2 inhibitors based on the tetrahydropteridin chemical scaffold. Eur J Med Chem. 2018;143:724-731 pubmed publisher
    Polo-like kinase 2 (Plk2) is a potential target for the treatment of cancer, which displays an important role in tumor cell proliferation and survival...
  82. Ma S, Liu M, Yuan Y, Erikson R. The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB. Mol Cancer Res. 2003;1:376-84 pubmed
    Identified as an immediate-early transcript, the serum-inducible kinase Snk bears sequence homology with the polo-like kinases...
  83. Liu L, Wang W, Zhao L, Guo B, Yang J, Zhao X, et al. Mir-126 inhibits growth of SGC-7901 cells by synergistically targeting the oncogenes PI3KR2 and Crk, and the tumor suppressor PLK2. Int J Oncol. 2014;45:1257-65 pubmed publisher
    ..We identified that the expression of miR-126 was decreased in gastric cancer cell lines and tissues. PLK2, a tumor suppressor gene, was directly regulated by miR-126 in SGC-7901 cells...
  84. Shan H, Wang T, Quan J. Crystal structure of the polo-box domain of polo-like kinase 2. Biochem Biophys Res Commun. 2015;456:780-4 pubmed publisher
    Polo-like kinase 2 (PLK2) is a crucial regulator in cell cycle progression, DNA damage response, and neuronal activity. PLK2 is characterized by the conserved N-terminal kinase domain and the unique C-terminal polo-box domain (PBD)...
  85. Yang H, Fang L, Zhan R, Hegarty J, Ren J, Hsiai T, et al. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Dev Biol. 2015;404:49-60 pubmed publisher
    ..Here, we show that Polo-like kinase 2 (PLK2) regulates Rap1 activity to guide endothelial tip cell lamellipodia formation and subsequent angiogenic sprouting...
  86. Dahmene M, Bérard M, Oueslati A. Dissecting the Molecular Pathway Involved in PLK2 Kinase-mediated α-Synuclein-selective Autophagic Degradation. J Biol Chem. 2017;292:3919-3928 pubmed publisher
    ..described a novel selective α-syn degradation pathway, catalyzed by the activity of the Polo-like kinase 2 (PLK2), capable of reducing α-syn protein expression and suppressing its toxicity in vivo However, the exact ..
  87. Yogosawa S, Hatakeyama S, Nakayama K, Miyoshi H, Kohsaka S, Akazawa C. Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase. J Biol Chem. 2005;280:41619-27 pubmed
    Serum-inducible kinase (SNK) is a member of polo-like kinases that serve as regulators of multiple events during cell division...
  88. Yun S, Moulaei T, Lim D, Bang J, Park J, Shenoy S, et al. Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat Struct Mol Biol. 2009;16:876-82 pubmed publisher
    ..minimal phosphopeptides that specifically interact with the PBD of human PLK1, but not those of the closely related PLK2 and PLK3...
  89. Wang D, Yang P, Zhang X, Liu Y. [Effects of dexmedetomidine on myocardium of rats with severe burn at early stage]. Zhonghua Shao Shang Za Zhi. 2017;33:677-681 pubmed publisher
    ..Data were processed with one-way analysis of variance and SNK test. Results: At PBH 6, EF value of rats in group BR [(98.0±2...
  90. Wang S, Xu B, Liou L, Ren Q, Huang S, Luo Y, et al. ?-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2. Proc Natl Acad Sci U S A. 2012;109:16119-24 pubmed publisher
    ..aSyn is a substrate of the yeast (and human) polo-like kinase Cdc5 (Plk2), and elevated levels of aSyn prevent Cdc5 from maintaining a normal level of GTP-bound Rho1, which is an essential ..
  91. Li J, Ma W, Wang P, Hurley P, Bunz F, Hwang P. Polo-like kinase 2 activates an antioxidant pathway to promote the survival of cells with mitochondrial dysfunction. Free Radic Biol Med. 2014;73:270-7 pubmed publisher
    We previously reported that Polo-like kinase 2 (PLK2) is highly expressed in cells with defective mitochondrial respiration and is essential for their survival...
  92. Zurnic I, Hutter S, Rzeha U, Stanke N, Reh J, Müllers E, et al. Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration. PLoS Pathog. 2016;12:e1005860 pubmed publisher
    ..yeast-two-hybrid (Y2H) screen with prototype FV (PFV) Gag protein as bait we identified human polo-like kinase 2 (hPLK2), a member of cell cycle regulatory kinases, as a new interactor of PFV capsids...