PLIN2

Summary

Gene Symbol: PLIN2
Description: perilipin 2
Alias: ADFP, ADRP, perilipin-2, adipophilin, adipose differentiation-related protein
Species: human
Products:     PLIN2

Top Publications

  1. Heid H, Moll R, Schwetlick I, Rackwitz H, Keenan T. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res. 1998;294:309-21 pubmed
    We report the human DNA and protein sequence of adipophilin and its association with the surface of lipid droplets...
  2. Larigauderie G, Cuaz Pérolin C, Younes A, Furman C, Lasselin C, Copin C, et al. Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of beta-oxidation. FEBS J. 2006;273:3498-510 pubmed
    ..In this study, we investigated the role of adipophilin on triglyceride accumulation and lipid-droplet formation in THP-1-derived macrophages (THP-1 macrophages)...
  3. Shaw C, Sherlock M, Stewart P, Wagenmakers A. Adipophilin distribution and colocalization with lipid droplets in skeletal muscle. Histochem Cell Biol. 2009;131:575-81 pubmed publisher
    ..The lipid droplet-associated protein adipophilin (the human orthologue of adipose differentiation-related protein) is ubiquitously expressed and is one of the ..
  4. Minnaard R, Schrauwen P, Schaart G, Jorgensen J, Lenaers E, Mensink M, et al. Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus. J Clin Endocrinol Metab. 2009;94:4077-85 pubmed publisher
    ..Lipid droplet proteins of the PAT [perilipin, adipocyte differentiation-related protein (ADRP), and TIP47] family have been shown to regulate lipid accumulation and intracellular metabolism in other tissues...
  5. Ostler D, Prieto V, Reed J, Deavers M, Lazar A, Ivan D. Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases. Mod Pathol. 2010;23:567-73 pubmed publisher
    b>Adipophilin is a monoclonal antibody against a protein on the surface of intracellular lipid droplets, and it was recently shown to be expressed in sebocytes and sebaceous lesions...
  6. Shepherd S, Cocks M, Tipton K, Ranasinghe A, Barker T, Burniston J, et al. Preferential utilization of perilipin 2-associated intramuscular triglycerides during 1 h of moderate-intensity endurance-type exercise. Exp Physiol. 2012;97:970-80 pubmed publisher
    The lipid droplet (LD)-associated protein perilipin 2 (PLIN2) appears to colocalize with LDs in human skeletal muscle fibres, although the function of PLIN2 in the regulation of intramuscular triglyceride (IMTG) metabolism is currently ..
  7. Heid H, Schnolzer M, Keenan T. Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane. Biochem J. 1996;320 ( Pt 3):1025-30 pubmed
    ..globules from humans, cows and rats contained a protein identified as adipocyte differentiation-related protein (ADRP) associated with the globule surface membrane material...
  8. Kimmel A, Brasaemle D, McAndrews Hill M, Sztalryd C, Londos C. Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. J Lipid Res. 2010;51:468-71 pubmed publisher
    ..Each gene member will incorporate the root term PERILIPIN (PLIN), the founding gene of the PAT family, with the different genes/proteins numbered sequentially. ..
  9. Shepherd S, Cocks M, Tipton K, Ranasinghe A, Barker T, Burniston J, et al. Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5. J Physiol. 2013;591:657-75 pubmed publisher
    ..that ET-induced increases in net IMTG breakdown and insulin sensitivity are related to increased expression of perilipin 2 (PLIN2) and perilipin 5 (PLIN5)...

More Information

Publications111 found, 100 shown here

  1. Larigauderie G, Furman C, Jaye M, Lasselin C, Copin C, Fruchart J, et al. Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages: potential role in atherogenesis. Arterioscler Thromb Vasc Biol. 2004;24:504-10 pubmed
    ..Excess lipid deposition in macrophages has been reported to modulate expression of several genes including adipophilin. In this study, we investigated the function of adipophilin in lipid accumulation and cholesterol efflux in THP-..
  2. Fujimoto Y, Itabe H, Sakai J, Makita M, Noda J, Mori M, et al. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Biochim Biophys Acta. 2004;1644:47-59 pubmed
    ..Adipose differentiation-related protein (ADRP) was the most abundant protein in the fraction...
  3. Nuotio K, Isoviita P, Saksi J, Ijas P, Pitkäniemi J, Sonninen R, et al. Adipophilin expression is increased in symptomatic carotid atherosclerosis: correlation with red blood cells and cholesterol crystals. Stroke. 2007;38:1791-8 pubmed
    b>Adipophilin is an adipose differentiation-related protein expressed in lipid-containing cells. Using DNA microarray analysis, we previously found the adipophilin gene (ADFP) to be overexpressed in symptomatic carotid plaques (CP)...
  4. Huang C, Chen Y, Yang J, Chen C, Ajuwon K, Chen S, et al. Docosahexaenoic acid increases accumulation of adipocyte triacylglycerol through up-regulation of lipogenic gene expression in pigs. Lipids Health Dis. 2017;16:33 pubmed publisher
    ..sizes, TAG content and expression of lipogenic-related genes including, adipose differentiated related protein (ADRP) and diacylglycerol acyltransferase 1 (DGAT1) were elevated by DHA in vivo and in vitro, indicating DHA promoted ..
  5. Ahn M, Kim M, Kwon R, Hwang J, Park K. Gene expression profiling and inhibition of adipose tissue accumulation of G. bimaculatus extract in rats on high fat diet. Lipids Health Dis. 2015;14:116 pubmed publisher
    ..The data suggest Fasin-related fatty acid synthesis and adipose differentiation related protein (Adfp), which is related to obesity, were upregulated by GB treatment, indicating their potential ..
  6. Kloepper J, Baris O, Reuter K, Kobayashi K, Weiland D, Vidali S, et al. Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions. J Invest Dermatol. 2015;135:679-689 pubmed publisher
    ..HF progenitor cell differentiation (Plet1, Lrig1 Lef1, and β-catenin), sebaceous gland development (adipophilin, Scd1, and oil red), and key mediators/markers of epithelial-mesenchymal interactions during skin morphogenesis ..
  7. Gamarra G, Ponsart C, Lacaze S, Nuttinck F, Cordova A, Mermillod P, et al. Oral propylene glycol modifies follicular fluid and gene expression profiles in cumulus-oocyte complexes and embryos in feed-restricted heifers. Reprod Fertil Dev. 2018;30:417-429 pubmed publisher
    ..Blastocyst perilipin 2 (PLIN2; also known as adipophilin), Bcl-2-associated X protein (BAX), SCL2A1 (facilitated glucose/fructose ..
  8. Suarez Vega A, Gutiérrez Gil B, Arranz J. Transcriptome expression analysis of candidate milk genes affecting cheese-related traits in 2 sheep breeds. J Dairy Sci. 2016;99:6381-6390 pubmed publisher
    ..CSN2, CSN3, CSN1S1, ENSOARG00000005099/PAEP, CSN1S2, LALBA), genes related to lipid metabolism (BTN1A1, XDH, FASN, ADFP, SCD, H-FABP, ACSS2), and one endogenous protease (CTSB)...
  9. Merz T, Vogt J, Wachter U, Calzia E, Szabo C, Wang R, et al. Impact of hyperglycemia on cystathionine-?-lyase expression during resuscitated murine septic shock. Intensive Care Med Exp. 2017;5:30 pubmed publisher
    ..proliferator-activated receptor gamma coactivator 1-alpha (PGC1?), and adipocyte differentiation-related protein (ADRP) expression was immunohistochemically investigated...
  10. Shi H, Zhang T, Li C, Wang J, Huang J, Li Z. trans-10,cis-12-Conjugated Linoleic Acid Affects Expression of Lipogenic Genes in Mammary Glands of Lactating Dairy Goats. J Agric Food Chem. 2017;65:9460-9467 pubmed publisher
    ..decreases of the mRNA expression levels of SREBF1, PPARG, LPL, CD36, FABP3, ACSL1, FASN, ACACA, DGAT2, TIP47, ADRP, and BTN1A1 genes in mammary glands (p < 0...
  11. Miyazaki M, Aoki M, Oba S, Sakata T, Nakagawa T, Nabeshima K. A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report. Mol Clin Oncol. 2017;7:539-542 pubmed publisher
    ..the tumor cells were positive for cyclin dependent kinase 4, mouse double minute 2 homolog (MDM2) and adipophilin. Fluorescence in situ hybridization (FISH) analysis revealed amplification of the MDM2 gene...
  12. Yamamoto Y, Nakamura T, Koyama H, Kanai T, Moritani S, Ichihara S. Sebaceous carcinoma of the breast: a case report. Surg Case Rep. 2017;3:38 pubmed publisher
    ..Sudan Black B-positive lipid droplets in the cytoplasm, and they were immunohistochemically positive for adipophilin. They were negative for estrogen receptor, progesterone receptor, and androgen receptor; positive for ..
  13. Yoshida T, Murayama H, Kawashima M, Nagahara R, Kangawa Y, Mizukami S, et al. Apocynin and enzymatically modified isoquercitrin suppress the expression of a NADPH oxidase subunit p22phox in steatosis-related preneoplastic liver foci of rats. Exp Toxicol Pathol. 2017;69:9-16 pubmed publisher
    ..reduced MG-increased preneoplastic liver lesions, glutathione S-transferase placental form (GST-P)-positive, adipophilin-negative liver foci, and tended to decrease MG-increased Ki-67-positive or active caspase-3-positive cells in ..
  14. Pawlik A, Wała M, Hać A, Felczykowska A, Herman Antosiewicz A. Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells. Phytomedicine. 2017;29:1-10 pubmed publisher
    ..manner which was associated with the oxidative stress, mitochondria dysfunction, increased Bax:Bcl2 ratio and ADRP levels. SF also potentiated autophagy which played a cytoprotective role...
  15. Urano M, Nagao T, Miyabe S, Ishibashi K, Higuchi K, Kuroda M. Characterization of mammary analogue secretory carcinoma of the salivary gland: discrimination from its mimics by the presence of the ETV6-NTRK3 translocation and novel surrogate markers. Hum Pathol. 2015;46:94-103 pubmed publisher
    ..vimentin, high-molecular-weight cytokeratin, cytokeratin 19, S-100, mammaglobin, MUC1, GATA-binding protein 3, adipophilin, α-amylase, DOG-1, SOX-10, and p63...
  16. Seki H, Sasaki K, Morinaga S, Asanuma F, Yanaihara H, Kaneda M, et al. [A Case of Glycogen-Rich Clear Cell Carcinoma of the Breast with Extensive Intraductal Components and Micrometastases to the Axillary Lymph Node]. Gan To Kagaku Ryoho. 2016;43:239-41 pubmed
    ..The cells were negative for adipophilin. GRCC was first reported by Hull et al. This is a rare type of breast carcinoma...
  17. Weissferdt A, Kalhor N, Moran C. Sebaceous lymphadenoma of the thymus: A clinicopathologic and immunohistochemical study of 2 cases. Hum Pathol. 2016;56:189-93 pubmed publisher
    ..2), cytokeratin 5/6, and for adipophilin in the sebaceous component. B- and T-cell markers were positive in the lymphoid component...
  18. Tang W, Ma W, Ding H, Lin M, Xiang L, Lin G, et al. Adenylyl cyclase 1 as a major isoform to generate cAMP signaling for apoA-1-mediated cholesterol efflux pathway. J Lipid Res. 2018;59:635-645 pubmed publisher
    ..Together, our results show that AC1 is a major isoform for apoA-1-activated cAMP signaling to promote cholesterol transport and exocytosis to the surface of THP-1 macrophage foam cells. ..
  19. Li J, Luo J, Wang H, Shi H, Zhu J, Sun Y, et al. Adipose triglyceride lipase regulates lipid metabolism in dairy goat mammary epithelial cells. Gene. 2015;554:125-30 pubmed publisher
    ..the expression of HSL for lipolysis, FABP3 for fatty acid transport, PPARα for fatty acid oxidation, ADFP, BTN1A1, and XDH for milk fat formation and secretion was down-regulated (P<0...
  20. Mitra R, Zheng M, Weiss E, Han Z. Genomic form of rhodopsin DNA nanoparticles rescued autosomal dominant Retinitis pigmentosa in the P23H knock-in mouse model. Biomaterials. 2018;157:26-39 pubmed publisher
    ..co-sgRho) into a homozygous RhoP23H/P23H knock-in (KI) RP mouse model, which has a severe phenotype of adRP. In addition, we have conjugated a cell penetrating TAT peptide sequence to our previously established CK30PEG10 ..
  21. Blanco Kelly F, García Hoyos M, Lopez Martinez M, Lopez Molina M, Riveiro Alvarez R, Fernandez San Jose P, et al. Dominant Retinitis Pigmentosa, p.Gly56Arg Mutation in NR2E3: Phenotype in a Large Cohort of 24 Cases. PLoS ONE. 2016;11:e0149473 pubmed publisher
    ..This study highlights the importance of p.Gly56Arg in the NR2E3 gene as a common mutation associated with adRP, and provides new clues to its phenotype, which can allow for a better clinical management and genetic counselling ..
  22. Takahashi H, Kutasy B, Friedmacher F, Takahashi T, Puri P. Expression of hepatic lipid droplets is decreased in the nitrofen model of congenital diaphragmatic hernia. Pediatr Surg Int. 2016;32:155-60 pubmed publisher
    ..Immunohistochemistry showed markedly decreased hepatic ADRP immunoreactivity in CDH fetuses compared to controls...
  23. Strom S, Clark M, Martinez A, Garcia S, Abelazeem A, Matynia A, et al. De Novo Occurrence of a Variant in ARL3 and Apparent Autosomal Dominant Transmission of Retinitis Pigmentosa. PLoS ONE. 2016;11:e0150944 pubmed publisher
    ..No additional putative causal variants in ARL3 were identified in the follow-up cohort, suggesting that if ARL3 variants can cause adRP it is an extremely rare phenomenon.
  24. Mutsuga M, Asaoka Y, Imura N, Miyoshi T, Togashi Y. Aminoglutethimide-induced lysosomal changes in adrenal gland in mice. Exp Toxicol Pathol. 2017;69:424-429 pubmed publisher
    ..Some vacuoles were positive for adipophilin, whereas others were positive for lysosome-associated membrane protein-2 on immunohistochemical staining, ..
  25. Zhang T, Ma Y, Wang H, Loor J, Xu H, Shi H, et al. Trans10, cis12 conjugated linoleic acid increases triacylglycerol accumulation in goat mammary epithelial cells in vitro. Anim Sci J. 2017;: pubmed publisher
    ..05) the expression of CD36 and ADRP. Overall, the data indicate that a side effect of de novo fatty acid synthesis inhibition by t10c12-CLA is the up-..
  26. Dahlhoff M, Camera E, Picardo M, Zouboulis C, Chan L, Chang B, et al. PLIN2, the major perilipin regulated during sebocyte differentiation, controls sebaceous lipid accumulation in vitro and sebaceous gland size in vivo. Biochim Biophys Acta. 2013;1830:4642-9 pubmed publisher
    ..Lipid accumulation was evaluated by Nile red staining and mass spectrometry. PLIN2 and PLIN3 are the most abundant perilipins in undifferentiated sebocytes...
  27. Shi H, Yu K, Luo J, Li J, Tian H, Zhu J, et al. Adipocyte differentiation-related protein promotes lipid accumulation in goat mammary epithelial cells. J Dairy Sci. 2015;98:6954-64 pubmed publisher
    ..Adipocyte differentiation-related protein (ADRP; gene symbol PLIN2) is a CLD-binding protein that is crucial for synthesis of mature CLD...
  28. Gushima R, Yao T, Kurisaki Arakawa A, Hara K, Hayashi T, Fukumura Y, et al. Expression of adipophilin in gastric epithelial neoplasia is associated with intestinal differentiation and discriminates between adenoma and adenocarcinoma. Virchows Arch. 2016;468:169-77 pubmed publisher
    b>Adipophilin, a lipid droplet-associated protein that regulates lipid droplet structure and formation, is expressed in a wide variety of tumors...
  29. Mittal R, Araujo I, Czanner G, Coupland S. Perforin expression in eyelid sebaceous carcinomas: a useful and specific immunomarker for the differential diagnosis of eyelid carcinomas. Acta Ophthalmol. 2016;94:e325-30 pubmed publisher
    ..These were stained using the monoclonal antibody for perforin, epithelial membrane antigen (EMA), Ber-EP4 and adipophilin (ADP)...
  30. Zhao S, Kanno Y, Li W, Wakatabi H, Sasaki T, Koike K, et al. Picrasidine N Is a Subtype-Selective PPAR?/? Agonist. J Nat Prod. 2016;79:879-85 pubmed publisher
    ..PPAR?/? agonists, which can induce the expression of not only ANGPTL4 but also other PPAR target genes, such as ADRP, PDK4, and CPT-1...
  31. Prieto Granada C, Rodriguez Waitkus P. Sebaceous Carcinoma of the Eyelid. Cancer Control. 2016;23:126-32 pubmed
    ..in the differential diagnosis of PSC are epithelial membrane antigen, Ber-Ep4, androgen receptor (AR), and adipophilin. To discern PSC from BCC, one should use EMA, Ber-Ep4, AR, and adipophilin, whereas discerning PSC from SCC can ..
  32. Lv J, Zhou G, Chen X, Chen H, Wu K, Xiang L, et al. Targeted RP9 ablation and mutagenesis in mouse photoreceptor cells by CRISPR-Cas9. Sci Rep. 2017;7:43062 pubmed publisher
    ..in the pre-mRNA splicing factor, RP9 (also known as PAP1), predispose autosomal dominant retinitis pigmentosa (adRP) with an early onset and severe vision loss...
  33. Katou Ichikawa C, Izawa T, Sasai H, Kuwamura M, Yamate J. Multiple Histiocytic Foam Cell Nodules in the Tongue of Miniature Dachshund Dogs. Vet Pathol. 2016;53:625-8 pubmed publisher
    ..positively for CD204 (macrophage scavenger receptor) and MHC class II and negatively for Iba-1, E-cadherin, adipophilin, cytokeratins, S-100, and nestin...
  34. Ekere N, Agwogie A, Ihedioha J. Studies of biosorption of Pb2+, Cd2+ and Cu2+ from aqueous solutions using Adansonia digitata root powders. Int J Phytoremediation. 2016;18:116-25 pubmed publisher
    The potentials of Adansonia digitata root powders (ADRP) for adsorption of Pb(2+), Cd(2+) and Cu(2+) from aqueous solutions was investigated...
  35. Wijesundera K, Izawa T, Tennakoon A, Golbar H, Tanaka M, Kuwamura M, et al. M1-/M2-macrophage polarization in pseudolobules consisting of adipohilin-rich hepatocytes in thioacetamide (TAA)-induced rat hepatic cirrhosis. Exp Mol Pathol. 2016;101:133-42 pubmed publisher
    ..b>Adipophilin (Adp) is localized on lipid droplet membrane in cytoplasm, and its increased expression is related to ..
  36. Shinde V, Kotla P, Strang C, Gorbatyuk M. Unfolded protein response-induced dysregulation of calcium homeostasis promotes retinal degeneration in rat models of autosomal dominant retinitis pigmentosa. Cell Death Dis. 2016;7:e2085 pubmed publisher
    The molecular mechanism of autosomal dominant retinitis pigmentosa (ADRP) in rats is closely associated with a persistently activated unfolded protein response (UPR)...
  37. Jakobiec F, Tu Y, Zakka F, Tong A. Dermatofibroma of the eyelid with monster cells. Surv Ophthalmol. 2017;62:533-540 pubmed publisher
    ..The background cells were either histiocytoid (many were adipophilin positive), spindled cells, or dendritiform cells without mitoses...
  38. Wang H, Zhu L, Hao J, Duan H, Liu S, Zhao S, et al. Co-regulation of SREBP-1 and mTOR ameliorates lipid accumulation in kidney of diabetic mice. Exp Cell Res. 2015;336:76-84 pubmed publisher
    ..1% followed by decreased FASN mRNA, ACC mRNA, ADRP protein and lipid droplets in HKC cells co-transfected with shRNA-SREBP-1 vector and kinase-dead mTOR vector...
  39. Cai Y, Yang Y, Chen X, He D, Zhang X, Wen X, et al. Circulating "LncPPARδ" From Monocytes as a Novel Biomarker for Coronary Artery Diseases. Medicine (Baltimore). 2016;95:e2360 pubmed publisher
    ..expression of peroxisome proliferator-activated receptor δ (PPARδ), Adipose Differentiation-Related Protein (ADRP), and Angiopoietin-like 4 (ANGPTL4) were affected by LncPPARδ silencing...
  40. Beryozkin A, Levy G, Blumenfeld A, Meyer S, Namburi P, Morad Y, et al. Genetic Analysis of the Rhodopsin Gene Identifies a Mosaic Dominant Retinitis Pigmentosa Mutation in a Healthy Individual. Invest Ophthalmol Vis Sci. 2016;57:940-7 pubmed publisher
    ..Mutations in the rhodopsin (RHO) gene are the most common cause of autosomal dominant RP (adRP) and are responsible for 16% to 35% of adRP cases in the Western population...
  41. Masuda Y, Itabe H, Odaki M, Hama K, Fujimoto Y, Mori M, et al. ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells. J Lipid Res. 2006;47:87-98 pubmed
    Adipose differentiation-related protein (ADRP) is a major protein associated with lipid droplets in various types of cells, including macrophage-derived foam cells and liver cells...
  42. Varela L, López S, Ortega Gómez A, Bermúdez B, Buers I, Robenek H, et al. Postprandial triglyceride-rich lipoproteins regulate perilipin-2 and perilipin-3 lipid-droplet-associated proteins in macrophages. J Nutr Biochem. 2015;26:327-36 pubmed publisher
  43. Daiger S, Sullivan L, Bowne S, Koboldt D, Blanton S, Wheaton D, et al. Identification of a Novel Gene on 10q22.1 Causing Autosomal Dominant Retinitis Pigmentosa (adRP). Adv Exp Med Biol. 2016;854:193-200 pubmed publisher
    ..0 at 0 % recombination in a six-generation family with autosomal dominant retinitis pigmentosa (adRP). All known adRP genes and X-linked RP genes were excluded in the family by a combination of methods...
  44. Makino A, Hullin Matsuda F, Murate M, Abe M, Tomishige N, Fukuda M, et al. Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes. Mol Biol Cell. 2016;27:3293-3304 pubmed
    ..free cholesterol accumulation induced the fusion of LDs, followed by degradation of the coat protein of LDs, perilipin 2 (PLIN2; also called adipophilin or adipose differentiation-related protein), and association of apolipoprotein ..
  45. Targett Adams P, Chambers D, Gledhill S, Hope R, Coy J, Girod A, et al. Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein. J Biol Chem. 2003;278:15998-6007 pubmed
    ..that is most frequently found at the surface of lipid droplets is adipocyte differentiation-related protein (ADRP)...
  46. Wolins N, Quaynor B, Skinner J, Tzekov A, Croce M, Gropler M, et al. OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes. 2006;55:3418-28 pubmed
    Lipid droplet proteins of the PAT (perilipin, adipophilin, and TIP47) family regulate cellular neutral lipid stores. We have studied a new member of this family, PAT-1, and found that it is expressed in highly oxidative tissues...
  47. Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Nakaigawa N, et al. Expression of adipose differentiation-related protein: a predictor of cancer-specific survival in clear cell renal carcinoma. Clin Cancer Res. 2007;13:152-60 pubmed
    We recently found that adipose differentiation-related protein (ADFP) is a potential diagnostic and prognostic biomarker for clear cell subtype renal cell carcinoma (RCC)...
  48. Hao H, Iihara K, Ishibashi Ueda H, Saito F, Hirota S. Correlation of thin fibrous cap possessing adipophilin-positive macrophages and intraplaque hemorrhage with high clinical risk for carotid endarterectomy. J Neurosurg. 2011;114:1080-7 pubmed publisher
    ..including fibrous cap thickness, plaque disruption, thrombus formation, intraplaque hemorrhage (IPH), and adipophilin expression were examined without information regarding clinical status...
  49. Schmitz E, Herwig Carl M, Holz F, Loeffler K. Sebaceous gland carcinoma of the ocular adnexa - variability in clinical and histological appearance with analysis of immunohistochemical staining patterns. Graefes Arch Clin Exp Ophthalmol. 2017;255:2277-2285 pubmed publisher
    ..2), epithelial membrane antigen (EMA), androgen receptor (AR441), perforin and adipophilin. SGC's were located in the upper (n = 2) or lower (n = 4) eyelid and were associated with various ..
  50. Tetzlaff M. Immunohistochemical markers informing the diagnosis of sebaceous carcinoma and its distinction from its mimics: Adipophilin and Factor XIIIa to the rescue?. J Cutan Pathol. 2017;: pubmed publisher
    ..In this issue of the Journal of Cutaneous Pathology, Tjarks et al. present a study that advances our understanding of the diagnosis of sebaceous neoplasms (in particular, sebaceous carcinoma) and the lesions that mimic them (1)...
  51. Kawasaki K, Eizuka M, Nakamura S, Endo M, Yanai S, Akasaka R, et al. Association between white opaque substance under magnifying colonoscopy and lipid droplets in colorectal epithelial neoplasms. World J Gastroenterol. 2017;23:8367-8375 pubmed publisher
    ..Immunohistochemistry was used to stain tumors with a monoclonal antibody specific to adipophilin as a marker of lipids...
  52. Bonilha V, Rayborn M, Bell B, Marino M, Beight C, Pauer G, et al. Retinal histopathology in eyes from patients with autosomal dominant retinitis pigmentosa caused by rhodopsin mutations. Graefes Arch Clin Exp Ophthalmol. 2015;253:2161-9 pubmed publisher
    To evaluate the histopathology in donor eyes from patients with autosomal dominant retinitis pigmentosa (ADRP) caused by p.P23H, p.P347T and p.P347L rhodopsin ( RHO ) gene mutations...
  53. Jester J, Potma E, Brown D. PPAR? Regulates Mouse Meibocyte Differentiation and Lipid Synthesis. Ocul Surf. 2016;14:484-494 pubmed publisher
    ..Rosiglitazone also increased the localization of PPAR? to the cytoplasm and up-regulated of PPAR?, ADP and ADFP mRNA...
  54. Shi H, Zhang C, Xu Z, Lou G, Liu J, Luo J, et al. Peroxisome proliferator-activated receptor delta regulates lipid droplet formation and transport in goat mammary epithelial cells. J Dairy Sci. 2018;101:2641-2649 pubmed publisher
    ..sulfoxide), overexpression of PPARD alone had no effect on mRNA expression of CD36, SCD1, FABP4, ACSL1, and ADRP. The cultures overexpressing PPARD with the PPARD ligand GW0742 (GW) upregulated the expression of CD36, FABP3, ..
  55. Nakamura N, Akashi T, Taneda T, Kogo H, Kikuchi A, Fujimoto T. ADRP is dissociated from lipid droplets by ARF1-dependent mechanism. Biochem Biophys Res Commun. 2004;322:957-65 pubmed
    Adipocyte differentiation-related protein (ADRP) is a member of PAT proteins existing in lipid droplets (LDs). By yeast two-hybrid screening, we identified ADP-ribosylation factor 1 (ARF1) as a binding partner of ADRP...
  56. Mitrova K, Karpisek M, Durilova M, Dragusin L, Nevoral J, Bronsky J. Development of high-sensitive ELISA method for detection of adipophilin levels in human colostrum and breast milk. J Clin Lab Anal. 2014;28:255-60 pubmed publisher
    To develop and validate high-sensitive (hs) ELISA method for detection of adipophilin (adipose differentiation-related protein, ADRP) in human breast milk (BM) and to analyze adipophilin levels in BM during 12 months of lactation...
  57. Dalen K, Ulven S, Arntsen B, Solaas K, Nebb H. PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver. J Lipid Res. 2006;47:931-43 pubmed
    The adipose differentiation-related protein (ADFP)/adipophilin belongs to a family of PAT (for perilipin, ADFP, and TIP47) proteins that associate on the surface of lipid droplets (LDs)...
  58. Ambrosio M, Piccaluga P, Ponzoni M, Rocca B, Malagnino V, Onorati M, et al. The alteration of lipid metabolism in Burkitt lymphoma identifies a novel marker: adipophilin. PLoS ONE. 2012;7:e44315 pubmed publisher
    ..These vacuoles are not identifiable in biopsy section as lipids are "lost" during tissue processing...
  59. Tobin K, Harsem N, Dalen K, Staff A, Nebb H, Duttaroy A. Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. J Lipid Res. 2006;47:815-23 pubmed
    ..Adipose differentiation-related protein (ADRP) is a lipid droplet-associated protein that has been ascribed a role in cellular fatty acid uptake and storage...
  60. Llorente Cortes V, Royo T, Juan Babot O, Badimon L. Adipocyte differentiation-related protein is induced by LRP1-mediated aggregated LDL internalization in human vascular smooth muscle cells and macrophages. J Lipid Res. 2007;48:2133-40 pubmed
    ..The adipocyte differentiation-related protein (ADRP) has been found on the surface of lipid droplets...
  61. Tanigawa K, Suzuki K, Nakamura K, Akama T, Kawashima A, Wu H, et al. Expression of adipose differentiation-related protein (ADRP) and perilipin in macrophages infected with Mycobacterium leprae. FEMS Microbiol Lett. 2008;289:72-9 pubmed publisher
    ..Recently, it was revealed that the lipid droplet-associated proteins, including ADRP and perilipin, play essential roles in lipid accumulation in adipocytes or macrophages...
  62. Fujii H, Ikura Y, Arimoto J, Sugioka K, Iezzoni J, Park S, et al. Expression of perilipin and adipophilin in nonalcoholic fatty liver disease; relevance to oxidative injury and hepatocyte ballooning. J Atheroscler Thromb. 2009;16:893-901 pubmed
    Perilipin and adipophilin, PAT family proteins, play important roles in lipid metabolism...
  63. Lee T, Mak K, Rackovsky O, Lin Y, Kwong A, Loke J, et al. Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation-related protein (ADRP). J Cell Physiol. 2010;223:648-57 pubmed publisher
    ..In non-adipose cells, adipose differentiation-related protein (ADRP) coats lipid droplets and regulates their formation and lipolysis; however its function in HSCs is unknown...
  64. Hisabe T, Yao K, Imamura K, Ishihara H, Yamasaki K, Yasaka T, et al. Novel Endoscopic Findings as Visualized by Magnifying Endoscopy with Narrow-Band Imaging: White Opaque Substance Is Present in Colorectal Hyperplastic Polyps. Digestion. 2016;93:127-31 pubmed publisher
    ..WOS was present in 21 of the 26 colorectal hyperplastic polyps (80.8%) based on the findings of ME with NBI. Adipophilin was present in 24 of the 26 colorectal hyperplastic polyps (92.3%)...
  65. Bildirici I, Roh C, Schaiff W, Lewkowski B, Nelson D, Sadovsky Y. The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma/retinoid X receptor. J Clin Endocrinol Metab. 2003;88:6056-62 pubmed
    Uptake and transplacental transfer of fatty acids is essential for fetal development. Human adipophilin and its murine ortholog adipocyte differentiation-related protein are lipid droplet-associated proteins that are implicated in ..
  66. Testa F, Ziviello C, Rinaldi M, Rossi S, Di Iorio V, Interlandi E, et al. Clinical phenotype of an Italian family with a new mutation in the PRPF8 gene. Eur J Ophthalmol. 2006;16:779-81 pubmed
    To report the clinical and functional characteristics of an autosomal dominant retinitis pigmentosa (ADRP) family with a novel point mutation (P2301S) in the PRPF8 gene.
  67. Chen J, Shi G, Concepcion F, Xie G, Oprian D, Chen J. Stable rhodopsin/arrestin complex leads to retinal degeneration in a transgenic mouse model of autosomal dominant retinitis pigmentosa. J Neurosci. 2006;26:11929-37 pubmed
    Over 100 rhodopsin mutation alleles have been associated with autosomal dominant retinitis pigmentosa (ADRP). These mutations appear to cause photoreceptor cell death through diverse molecular mechanisms...
  68. Pawella L, Hashani M, Schirmacher P, Straub B. [Lipid droplet-associated proteins in steatosis. Effects of induction and siRNA-mediated downregulation of PAT proteins in cell culture models of hepatocyte steatosis]. Pathologe. 2010;31 Suppl 2:126-31 pubmed publisher
    ..The surface of lipid droplets is stabilized by amphiphilic proteins of the PAT family (perilipin, adipophilin, TIP47). We recently showed that PAT proteins are differentially expressed in liver...
  69. Branche E, Conzelmann S, Parisot C, Bedert L, Lévy P, Bartosch B, et al. Hepatitis C Virus Increases Occludin Expression via the Upregulation of Adipose Differentiation-Related Protein. PLoS ONE. 2016;11:e0146000 pubmed publisher
    ..in HCV life cycle, we assessed the relationship between HCV and the adipose differentiation-related protein (ADRP), a lipid droplet-associated protein...
  70. Tolkach Y, Lüders C, Meller S, Jung K, Stephan C, Kristiansen G. Adipophilin as prognostic biomarker in clear cell renal cell carcinoma. Oncotarget. 2017;8:28672-28682 pubmed publisher
    To study the expression of adipophilin (PLIN2), a lipid storage-associated cell protein, in different subtypes of renal cell cancer and to elucidate its prognostic value...
  71. Sarov Blat L, Kiss R, Haidar B, Kavaslar N, Jaye M, Bertiaux M, et al. Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol. Arterioscler Thromb Vasc Biol. 2007;27:1115-22 pubmed
    ..of other genes regulated by PPARgamma, including CD36, adipocyte fatty acid binding protein (FABP4), and adipophilin (ADFP). In contrast, PPARdelta expression was increased in MDM from low HDL-C groups...
  72. Urahama Y, Ohsaki Y, Fujita Y, Maruyama S, Yuzawa Y, Matsuo S, et al. Lipid droplet-associated proteins protect renal tubular cells from fatty acid-induced apoptosis. Am J Pathol. 2008;173:1286-94 pubmed publisher
    ..Therapeutic manipulation of these LD-associated proteins could aid in the amelioration of nephritic diseases. ..
  73. Suzuki M, Otsuka T, Ohsaki Y, Cheng J, Taniguchi T, Hashimoto H, et al. Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets. Mol Biol Cell. 2012;23:800-10 pubmed publisher
    ..These results indicate that ApoB after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 and UBXD8 are engaged in the predislocation and postdislocation steps, respectively. ..
  74. Conte M, Vasuri F, Trisolino G, Bellavista E, Santoro A, Degiovanni A, et al. Increased Plin2 expression in human skeletal muscle is associated with sarcopenia and muscle weakness. PLoS ONE. 2013;8:e73709 pubmed publisher
    ..IMTG) deposition in lipid droplets, which are associated with perilipin proteins, such as Perilipin2 (Plin2)...
  75. De Paepe M, Mao Q, Chu S, Zhang Y, Luks F. Clinicoplacental correlates of amniocyte vacuolization in association with gastroschisis. Placenta. 2017;57:87-93 pubmed publisher
    ..membrane sections were reviewed for presence and extent of amniocyte vacuolization, and immunostained for adipophilin, a lipid droplet-associated protein...
  76. Wang H, Hu L, Dalen K, Dorward H, Marcinkiewicz A, Russell D, et al. Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. J Biol Chem. 2009;284:32116-25 pubmed publisher
    ..we investigate the mechanisms by which PAT family members, perilipin A, adipose differentiation-related protein (ADFP), and LSDP5, control lipolysis catalyzed by hormone-sensitive lipase (HSL), a major lipase in adipocytes and ..
  77. Magné J, Aminoff A, Perman Sundelin J, Mannila M, Gustafsson P, Hultenby K, et al. The minor allele of the missense polymorphism Ser251Pro in perilipin 2 (PLIN2) disrupts an ?-helix, affects lipolysis, and is associated with reduced plasma triglyceride concentration in humans. FASEB J. 2013;27:3090-9 pubmed publisher
    b>Perilipin 2 (PLIN2) is the most abundant lipid droplet (LD)-associated protein in nonadipose tissue, and its expression correlates with intracellular lipid accumulation...
  78. Sletten A, Seline A, Rudd A, Logsdon M, Listenberger L. Surface features of the lipid droplet mediate perilipin 2 localization. Biochem Biophys Res Commun. 2014;452:422-7 pubmed publisher
    ..These dynamic structures are associated with and regulated by numerous proteins. Perilipin 2, an abundant protein on most lipid droplets, promotes neutral lipid accumulation in lipid droplets...
  79. Rowe E, Mimmack M, Barbosa A, Haider A, Isaac I, Ouberai M, et al. Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3. J Biol Chem. 2016;291:6664-78 pubmed publisher
  80. Graffmann N, Ring S, Kawala M, Wruck W, Ncube A, Trompeter H, et al. Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha. Stem Cells Dev. 2016;25:1119-33 pubmed publisher
    ..We observed an upregulation of the lipid droplet coating protein Perilipin 2 (PLIN2), as well as of numerous genes of the peroxisome proliferator-activated receptor (PPAR) pathway, which ..
  81. Persson J, Degerman E, Nilsson J, Lindholm M. Perilipin and adipophilin expression in lipid loaded macrophages. Biochem Biophys Res Commun. 2007;363:1020-6 pubmed
    ..Expression of two proteins, perilipin and adipophilin, was quantified by Western blots of cell lysates...
  82. El Ekiaby N, Mekky R, Riad S, Elhelw D, El Sayed M, Esmat G, et al. miR-148a and miR-30a limit HCV-dependent suppression of the lipid droplet protein, ADRP, in HCV infected cell models. J Med Virol. 2017;89:653-659 pubmed publisher
    ..C Virus (HCV) promotes lipid droplet (LD) formation and perturbs the expression of the LD associated PAT proteins ADRP and TIP47, to promote its own lifecycle...
  83. Chen F, Yang Z, Wang X, Liu Y, Yang Y, Li L, et al. Adipophilin affects the expression of TNF-alpha, MCP-1, and IL-6 in THP-1 macrophages. Mol Cell Biochem. 2010;337:193-9 pubmed publisher
    ..Recent studies show that adipophilin might be involved in inflammatory processes in macrophages...
  84. Conte M, Vasuri F, Bertaggia E, Armani A, Santoro A, Bellavista E, et al. Differential expression of perilipin 2 and 5 in human skeletal muscle during aging and their association with atrophy-related genes. Biogerontology. 2015;16:329-40 pubmed publisher
    ..In skeletal muscle the most abundant are Plin2 and Plin5...
  85. Ohsaki Y, Kawai T, Yoshikawa Y, Cheng J, Jokitalo E, Fujimoto T. PML isoform II plays a critical role in nuclear lipid droplet formation. J Cell Biol. 2016;212:29-38 pubmed publisher
    ..These results corroborated that PML-II plays a critical role in generating nuclear LDs in specific cell types. ..
  86. Adrian L, Lenski M, Tödter K, Heeren J, Bohm M, Laufs U. AMPK Prevents Palmitic Acid-Induced Apoptosis and Lipid Accumulation in Cardiomyocytes. Lipids. 2017;52:737-750 pubmed publisher
    ..expression of the FA translocase CD36 (FAT/CD36) to 163 ± 23% and adipose-differentiation-related-protein (ADRP), a sensitive marker of lipid accumulation, to 168 ± 42%...
  87. Tan Y, Zhang H, Guo D, Wang J, Yuan X, Yuan Z. Adipophilin Involved in Lipopolysaccharide-Induced Inflammation in RAW264.7 Cell via Extracellular Signal-Regulated Kinase 1/2-Peroxisome Proliferator-Activated Receptor Gamma Pathway. DNA Cell Biol. 2017;36:1159-1167 pubmed publisher
    ..Here, we study the role of adipophilin in LPS-induced inflammation. After RAW264...
  88. Forcheron F, Legedz L, Chinetti G, Feugier P, Letexier D, Bricca G, et al. Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression. Arterioscler Thromb Vasc Biol. 2005;25:1711-7 pubmed
    ..It may also depend on proteins surrounding lipid droplets, adipophilin, and perilipins...
  89. Imanishi Y, Sun W, Maeda T, Maeda A, Palczewski K. Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. J Biol Chem. 2008;283:25091-102 pubmed publisher
    ..Here we report studies of mice lacking exons 2 and 3 of the gene encoding adipose differentiation-related protein (Adfp), a structural component of RESTs...
  90. Feng X, Yuan Y, Wang C, Feng J, Yuan Z, Zhang X, et al. Autophagy involved in lipopolysaccharide-induced foam cell formation is mediated by adipose differentiation-related protein. Lipids Health Dis. 2014;13:10 pubmed publisher
    ..the formation of foam cells and was at least partially dependent on adipose differentiation-related protein (ADRP). Foam cell formation was evaluated by Oil red O staining...
  91. Maier A, Wu H, Cordasic N, Oefner P, Dietel B, Thiele C, et al. Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E-deficient mice. FASEB J. 2017;31:4971-4984 pubmed publisher
    ..and function in murine macrophages, compared it to the LD adipose differentiation-related protein (Adrp)/perilipin 2 (Plin2), and investigated its effects on atherogenesis in apolipoprotein E-deficient (ApoE-/-)..
  92. Straub B, Stoeffel P, Heid H, Zimbelmann R, Schirmacher P. Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis. Hepatology. 2008;47:1936-46 pubmed publisher
    ..share homologous sequences and domains, the so-called PAT proteins, named after their constituents, perilipin, adipophilin, and TIP47...