PLEC

Summary

Gene Symbol: PLEC
Description: plectin
Alias: EBS1, EBSMD, EBSND, EBSO, EBSOG, EBSPA, HD1, LGMD2Q, PCN, PLEC1, PLEC1b, PLTN, plectin, hemidesmosomal protein 1, plectin 1, intermediate filament binding protein 500kDa
Species: human
Products:     PLEC

Top Publications

  1. Gress T, Müller Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, et al. A pancreatic cancer-specific expression profile. Oncogene. 1996;13:1819-30 pubmed
    ..In addition this has led to the identification of novel differentially expressed genes, which represent potential oncogenes or disease-associated markers and may be helpful for the development of therapeutic or diagnostic modalities. ..
  2. Tian R, Gregor M, Wiche G, Goldman J. Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease. Am J Pathol. 2006;168:888-97 pubmed
    ..Here, we describe the expression of the cytoskeletal linker protein plectin in the AxD brain...
  3. Malecz N, Foisner R, Stadler C, Wiche G. Identification of plectin as a substrate of p34cdc2 kinase and mapping of a single phosphorylation site. J Biol Chem. 1996;271:8203-8 pubmed
    b>Plectin is an in vitro substrate for various kinases present in cell lysates from mitotic and interphase Chinese hamster ovary cells...
  4. Smith F, Eady R, Leigh I, McMillan J, Rugg E, Kelsell D, et al. Plectin deficiency results in muscular dystrophy with epidermolysis bullosa. Nat Genet. 1996;13:450-7 pubmed
    We report that mutation in the gene for plectin, a cytoskeleton-membrane anchorage protein, is a cause of autosomal recessive muscular dystrophy associated with skin blistering (epidermolysis bullosa simplex)...
  5. Schroder R, Fürst D, Klasen C, Reimann J, Herrmann H, van der Ven P. Association of plectin with Z-discs is a prerequisite for the formation of the intermyofibrillar desmin cytoskeleton. Lab Invest. 2000;80:455-64 pubmed
    b>Plectin is a high-molecular mass protein (approximately 500 kd) that binds actin, intermediate filaments, and microtubules. Mutations of the plectin gene cause a generalized blistering skin disorder and muscular dystrophy...
  6. Pfendner E, Rouan F, Uitto J. Progress in epidermolysis bullosa: the phenotypic spectrum of plectin mutations. Exp Dermatol. 2005;14:241-9 pubmed
    b>Plectin, a large multidomain adhesive protein with versatile binding functions, is expressed in a number of tissues and cell types...
  7. Chiaverini C, Charlesworth A, Meneguzzi G, Lacour J, Ortonne J. Epidermolysis bullosa simplex with muscular dystrophy. Dermatol Clin. 2010;28:245-55, viii pubmed publisher
    ..dystrophy (MIM 226670) or pyloric atresia (MIM 612138), have been linked to genetic mutations in the gene for plectin (PLEC). PLEC mutations have also been found in 2 families with the rare dominant Ogna form of EBS...
  8. Herrmann H, Wiche G. Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin. J Biol Chem. 1987;262:1320-5 pubmed
    Structural and functional characteristics of plectin from intermediate filament preparations of rat glioma C6 cells were compared to those of the intermediate filament-associated protein of Mr = 300,000 (IFAP-300K) of baby hamster kidney ..
  9. Gache Y, Chavanas S, Lacour J, Wiche G, Owaribe K, Meneguzzi G, et al. Defective expression of plectin/HD1 in epidermolysis bullosa simplex with muscular dystrophy. J Clin Invest. 1996;97:2289-98 pubmed
    ..is not reactive with antibodies 6C6, 10F6, or 5B3 raised against the intermediate filament-associated protein plectin. Immunofluorescence and Western analysis of explanted MD-EBS keratinocytes confirmed a deficient expression of ..

More Information

Publications102 found, 100 shown here

  1. McLean W, Pulkkinen L, Smith F, Rugg E, Lane E, Bullrich F, et al. Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization. Genes Dev. 1996;10:1724-35 pubmed
    b>Plectin is a widely expressed high molecular weight protein that is involved in cytoskeleton-membrane attachment in epithelial cells, muscle, and other tissues...
  2. Nikolic B, Mac Nulty E, Mir B, Wiche G. Basic amino acid residue cluster within nuclear targeting sequence motif is essential for cytoplasmic plectin-vimentin network junctions. J Cell Biol. 1996;134:1455-67 pubmed
    We have generated a series of plectin deletion and mutagenized cDNA constructs to dissect the functional sequences that mediate plectin's interaction with intermediate filament (IF) networks, and scored their ability to coalign or ..
  3. Wiche G. Role of plectin in cytoskeleton organization and dynamics. J Cell Sci. 1998;111 ( Pt 17):2477-86 pubmed
    b>Plectin and its isoforms are versatile cytoskeletal linker proteins of very large size (>500 kDa) that are abundantly expressed in a wide variety of mammalian tissues and cell types...
  4. Andra K, Nikolic B, Stöcher M, Drenckhahn D, Wiche G. Not just scaffolding: plectin regulates actin dynamics in cultured cells. Genes Dev. 1998;12:3442-51 pubmed
    b>Plectin, a major linker and scaffolding protein of the cytoskeleton, has been shown to be essential for the mechanical integrity of skin, skeletal muscle, and heart...
  5. Fuchs P, Zörer M, Rezniczek G, Spazierer D, Oehler S, Castanon M, et al. Unusual 5' transcript complexity of plectin isoforms: novel tissue-specific exons modulate actin binding activity. Hum Mol Genet. 1999;8:2461-72 pubmed
    b>Plectin, the most versatile cytolinker identified to date, has essential functions in maintaining the mechanical integrity of skin, skeletal muscle and heart, as indicated by analyses of plectin-deficient mice and humans...
  6. Hopkinson S, Jones J. The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome. Mol Biol Cell. 2000;11:277-86 pubmed
    ..These data provide new insight into those interactions of the molecules of the hemidesmosome that are necessary for its function in integrating epithelial and connective tissue types. ..
  7. Andrä K, Kornacker I, Jörgl A, Zörer M, Spazierer D, Fuchs P, et al. Plectin-isoform-specific rescue of hemidesmosomal defects in plectin (-/-) keratinocytes. J Invest Dermatol. 2003;120:189-97 pubmed
    The various plectin isoforms are among the major crosslinking elements of the cytoskeleton. The importance of plectin in epithelia is convincingly supported by the severe skin blistering observed in plectin-deficient humans and mice...
  8. Rezniczek G, Abrahamsberg C, Fuchs P, Spazierer D, Wiche G. Plectin 5'-transcript diversity: short alternative sequences determine stability of gene products, initiation of translation and subcellular localization of isoforms. Hum Mol Genet. 2003;12:3181-94 pubmed
    b>Plectin is a large cytoskeletal linker protein expressed as several different isoforms from a highly complex gene. This transcript diversity is mainly caused by short 5'-sequences contained in alternative first exons...
  9. Koster J, van Wilpe S, Kuikman I, Litjens S, Sonnenberg A. Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes. Mol Biol Cell. 2004;15:1211-23 pubmed
    We have previously shown that plectin is recruited into hemidesmosomes through association of its actin-binding domain (ABD) with the first pair of fibronectin type III (FNIII) repeats and a small part of the connecting segment (residues ..
  10. Osmanagic Myers S, Wiche G. Plectin-RACK1 (receptor for activated C kinase 1) scaffolding: a novel mechanism to regulate protein kinase C activity. J Biol Chem. 2004;279:18701-10 pubmed
    ..of receptor for activated C kinase 1 (RACK1) to the cytoskeleton through the cytoskeletal linker protein plectin during the initial stages of cell adhesion...
  11. Pfendner E, Uitto J. Plectin gene mutations can cause epidermolysis bullosa with pyloric atresia. J Invest Dermatol. 2005;124:111-5 pubmed
    ..followed by heteroduplex scanning and/or direct nucleotide sequencing revealed homozygous mutations in the plectin gene (PLEC1), encoding another hemidesmosomal protein previously linked to EB with muscular dystrophy...
  12. Ding Y, Zhang L, Goodwin J, Wang Z, Liu B, Zhang J, et al. Plectin regulates the signaling and trafficking of the HIV-1 co-receptor CXCR4 and plays a role in HIV-1 infection. Exp Cell Res. 2008;314:590-602 pubmed
    ..In the present study, we demonstrated that the CXCR4 formed a complex with the cytolinker protein plectin in a ligand-dependent manner in HEK293 cells stably expressing CXCR4...
  13. Rezniczek G, Walko G, Wiche G. Plectin gene defects lead to various forms of epidermolysis bullosa simplex. Dermatol Clin. 2010;28:33-41 pubmed publisher
    b>Plectin is an important organizer of the keratin filament cytoskeleton in basal keratinocytes. It is essential for anchoring these filaments to the extracellular matrix via hemidesmosomal integrins...
  14. Natsuga K, Nishie W, Akiyama M, Nakamura H, Shinkuma S, McMillan J, et al. Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex. Hum Mutat. 2010;31:308-16 pubmed publisher
    b>Plectin is a cytoskeletal linker protein that has a dumbbell-like structure with a long central rod and N- and C-terminal globular domains...
  15. Katada K, Tomonaga T, Satoh M, Matsushita K, Tonoike Y, Kodera Y, et al. Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma. J Proteomics. 2012;75:1803-15 pubmed publisher
    ..Western blotting and immunohistochemical analysis confirmed that the expression of plectin was significantly increased in most cancer tissues as compared with non-cancer tissues...
  16. Liu C, Maercker C, Castanon M, Hauptmann R, Wiche G. Human plectin: organization of the gene, sequence analysis, and chromosome localization (8q24). Proc Natl Acad Sci U S A. 1996;93:4278-83 pubmed
    b>Plectin, a 500-kDa intermediate filament binding protein, has been proposed to provide mechanical strength to cells and tissues by acting as a cross-linking element of the cytoskeleton...
  17. Elliott C, Becker B, Oehler S, Castanon M, Hauptmann R, Wiche G. Plectin transcript diversity: identification and tissue distribution of variants with distinct first coding exons and rodless isoforms. Genomics. 1997;42:115-25 pubmed
    b>Plectin is a widely expressed protein that is very large in size and that has all the attributes of a multifunctional crosslinking and organizing element of the cytoskeleton...
  18. Geerts D, Fontao L, Nievers M, Schaapveld R, Purkis P, Wheeler G, et al. Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding. J Cell Biol. 1999;147:417-34 pubmed
    ..We have investigated the recruitment of plectin into hemidesmosomes by the alpha6beta4 integrin and have shown that the cytoplasmic domain of the beta4 subunit ..
  19. Stiborova M, Cechova T, Bořek Dohalská L, Moserova M, Frei E, Schmeiser H, et al. Activation and detoxification metabolism of urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone by rat and mouse hepatic microsomes. Neuro Endocrinol Lett. 2012;33 Suppl 3:8-15 pubmed
    ..pretreated with Sudan I, β-naphthoflavone (β-NF), phenobarbital (PB), ethanol and pregnenolon 16α-carbonitrile (PCN), the inducers of cytochromes P450 (CYP) 1A1, 1A1/2, 2B, 2E1 and 3A, respectively, were used in this study...
  20. Dempsey J, Cui J. Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver. Drug Metab Dispos. 2019;47:329-339 pubmed publisher
    ..lncRNAs, RNA-Seq was performed from livers of adult male C57BL/6 mice treated with corn oil, the PXR agonist PCN, or the CAR agonist 1, 4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP)...
  21. Villa C, Ryan T, Collins J, Taylor M, Lucky A, Jefferies J. Left ventricular non-compaction cardiomyopathy associated with epidermolysis bullosa simplex with muscular dystrophy and PLEC1 mutation. Neuromuscul Disord. 2015;25:165-8 pubmed publisher
    b>Plectin mutations have been reported in epidermolysis bullosa simplex with muscular dystrophy. We report the first case of left ventricular non-compaction in an 18-year-old male with epidermolysis bullosa simplex with muscular dystrophy...
  22. Mossine V, Chance D, Waters J, Mawhinney T. Interaction of Bacterial Phenazines with Colistimethate in Bronchial Epithelial Cells. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..toxins, pyocyanin (PYO), 1-hydroxyphenazine (1-HP), phenazine-1-carboxylic acid (PCA), and phenazine-1-carboxamide (PCN), and two commonly prescribed polymyxin drugs, colistin-colistimethate sodium (CMS) and polymyxin B, in three human ..
  23. Costa K, Bergkessel M, Saunders S, Korlach J, Newman D. Enzymatic Degradation of Phenazines Can Generate Energy and Protect Sensitive Organisms from Toxicity. MBio. 2015;6:e01520-15 pubmed publisher
    ..degradation of three Pseudomonas-derived phenazines: phenazine-1-carboxylic acid (PCA), phenazine-1-carboxamide (PCN), and pyocyanin (PYO). PCA can be used as the sole carbon source for growth by these organisms...
  24. Jeffries J, Jia J, Choi W, Choe S, Miao J, Xu Y, et al. Pseudomonas aeruginosa pyocyanin modulates mucin glycosylation with sialyl-Lewis(x) to increase binding to airway epithelial cells. Mucosal Immunol. 2016;9:1039-1050 pubmed publisher
    ..We found pyocyanin (PCN) to be a potent inducer of sialyl-Lewis(x) in both mouse airways and in primary and immortalized CF and non-CF ..
  25. Hassani Nezhad Gashti F, Rysa J, Kummu O, Näpänkangas J, Buler M, Karpale M, et al. Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver. Biochem Pharmacol. 2018;148:253-264 pubmed publisher
    ..PXR ligand pregnenolone-16ɑ-carbonitrile (PCN) impaired glucose tolerance in the wildtype mice but not in the PXR knockout mice...
  26. Virreira Winter S, Zychlinsky A. The bacterial pigment pyocyanin inhibits the NLRP3 inflammasome through intracellular reactive oxygen and nitrogen species. J Biol Chem. 2018;293:4893-4900 pubmed publisher
    ..The phenazine pyocyanin (PCN) is a virulence factor of Pseudomonas aeruginosa and generates superoxide in cells...
  27. Patel D, Rathinam M, Jarvis C, Mahimainathan L, Henderson G, Narasimhan M. Role for Cystathionine ? Lyase (CSE) in an Ethanol (E)-Induced Lesion in Fetal Brain GSH Homeostasis. Int J Mol Sci. 2018;19: pubmed publisher
    ..This was associated with a significant reduction in cystathionine ?-lyase (CSE) protein expression in PCN (p < 0.05) and in fetal cerebral cortex in utero (53%, p < 0...
  28. Garg A, Zhao A, Erickson S, Mukherjee S, Lau A, Alston L, et al. Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation. J Pharmacol Exp Ther. 2016;359:91-101 pubmed publisher
    ..In vivo, activation of the PXR [pregnenolone 16α-carbonitrile (PCN)] attenuated barrier disruption induced by toll-like receptor 4 activation in wild-type, but not Pxr-/-, mice...
  29. Santos Lopez A, Bernabe Balas C, Ares Arroyo M, Ortega Huedo R, Hoefer A, San Millan A, et al. A Naturally Occurring Single Nucleotide Polymorphism in a Multicopy Plasmid Produces a Reversible Increase in Antibiotic Resistance. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..This coexistence produced an increase of the total plasmid copy number (PCN) in the host bacteria, leading to a rise in both the antibiotic resistance level and the metabolic burden produced ..
  30. Kumar A, Sunita P, Jha S, Pattanayak S. 7,8-Dihydroxycoumarin exerts antitumor potential on DMBA-induced mammary carcinogenesis by inhibiting ER?, PR, EGFR, and IGF1R: involvement of MAPK1/2-JNK1/2-Akt pathway. J Physiol Biochem. 2018;74:223-234 pubmed publisher
    ..progesterone receptor (PR)), growth factor receptors (EGFR and IGFR), 17?-hydroxysteroid dehydrogenase type 1 (17?-HD1), and aromatase...
  31. Liang Y, Fu Y, Qi R, Wang M, Yang N, He L, et al. Cartilage oligomeric matrix protein is a natural inhibitor of thrombin. Blood. 2015;126:905-14 pubmed publisher
    ..24 μM). In particular, blockage of thrombin exosites with compounds specific for exosite I (hirudin and HD1 aptamer) or exosite II (heparin and HD22 aptamer) impaired the COMP-thrombin interaction, indicating a 2-site ..
  32. Liu Y, Howarth A, Hupp J, Farha O. Selective Photooxidation of a Mustard-Gas Simulant Catalyzed by a Porphyrinic Metal-Organic Framework. Angew Chem Int Ed Engl. 2015;54:9001-5 pubmed publisher
    ..At room temperature and neutral pH value, singlet oxygen is generated by PCN-222/MOF-545 using an inexpensive and commercially available light-emitting diode...
  33. Wang X, Lu W, Gu Z, Wei Z, Zhou H. Topology-guided design of an anionic bor-network for photocatalytic [Ru(bpy)3](2+) encapsulation. Chem Commun (Camb). 2016;52:1926-9 pubmed publisher
    An anionic metal-organic framework, PCN-99, has been synthesized through a topology-guided strategy; its underlying bor-net is realized by the use of a tetrahedral [In(COO)4](-) node and a judiciously designed trigonal planar linker...
  34. Li F, Jin J, Tan D, Xu J, Dhanjai -, Ni Y, et al. High performance solid-phase extraction cleanup method coupled with gas chromatography-triple quadrupole mass spectrometry for analysis of polychlorinated naphthalenes and dioxin-like polychlorinated biphenyls in complex samples. J Chromatogr A. 2016;1448:1-8 pubmed publisher
    ..The limits of detection (LODs) of PCN and dl-PCB congeners were in the range of 0.6-19.1pgg(-1) and 0.4-8.6pgg(-1), respectively...
  35. Wozniak L, Soprovich A, Rees S, Frank L, Johnson S, Majumdar S, et al. Impact of Organizational Stability on Adoption of Quality-Improvement Interventions for Diabetes in Primary Care Settings. Can J Diabetes. 2015;39 Suppl 3:S100-12 pubmed publisher
    ..and maintenance (RE-AIM) framework to evaluate adoption of the quality-improvement interventions in the PCN setting. We undertook semistructured interviews with PCN staff (n=24); systematic documentation (e.g...
  36. Xu F, Zhang R, Li Y, Zhang Q, Wang W. Theoretical Mechanistic and Kinetic Studies on Homogeneous Gas-Phase Formation of Polychlorinated Naphthalene from 2-Chlorophenol as Forerunner. Int J Mol Sci. 2015;16:25641-56 pubmed publisher
    ..Chlorophenols (CPs) are the most important forerunners of PCNs. A comprehensive comprehension of PCN formation procedure from CPs is a precondition for reducing the discharge of PCNs...
  37. Halim W, van der Weegen W, Lim T, Wullems J, Vissers K. Percutaneous Cervical Nucleoplasty vs. Pulsed Radio Frequency of the Dorsal Root Ganglion in Patients with Contained Cervical Disk Herniation; A Prospective, Randomized Controlled Trial. Pain Pract. 2017;17:729-737 pubmed publisher
    ..This stimulated the clinical usage of minimally invasive treatments such as percutaneous nucleoplasty (PCN) and pulsed radio frequency (PRF). However, scientific evidence on both treatments is limited...
  38. Packiam V, Agrawal V, Cohen A, Pariser J, Johnson S, Bales G, et al. Lessons from 151 ureteral reimplantations for postcystectomy ureteroenteric strictures: A single-center experience over a decade. Urol Oncol. 2017;35:112.e19-112.e25 pubmed publisher
    ..Most patients underwent preoperative drainage by percutaneous nephrostomy (PCN; 43%) or percutaneous nephroureterostomy (PCNU; 44%)...
  39. Jones B, Li W, Cao J, Hoffman T, Gerk P, Vore M. The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2). Mol Pharmacol. 2005;68:701-10 pubmed
    ..expression, and degradation in control female, 19- and 20-day pregnant, and pregnenolone-16alpha-carbonitrile (PCN)-treated rats using in vivo metabolic-labeling studies with [35S]cysteine/methionine or [14C]NaHCO3, polysomal ..
  40. Schneider M, Schneider S, Zühlke Jenisch R, Klapper W, Sundström C, Hartmann S, et al. Alterations of the CD58 gene in classical Hodgkin lymphoma. Genes Chromosomes Cancer. 2015;54:638-45 pubmed publisher
    ..nucleotide polymorphism chip analysis revealed homozygous deletions within the CD58 gene in two cHL cell lines (SUP-HD1 and U-HO1)...
  41. Jin R, Zhan J, Liu G, Zhao Y, Zheng M. Variations and factors that influence the formation of polychlorinated naphthalenes in cement kilns co-processing solid waste. J Hazard Mater. 2016;315:117-25 pubmed publisher
    ..Polychlorinated naphthalene (PCN) formation and emission from cement kilns co-processing sorted municipal solid waste, sewage sludge, and waste acid,..
  42. de Pretis N, Mukewar S, Aryal Khanal A, Bi Y, Takahashi N, Chari S. Pancreatic cysts: Diagnostic accuracy and risk of inappropriate resections. Pancreatology. 2017;17:267-272 pubmed publisher
    Pancreatic cystic neoplasms (PCN) frequently undergo surgery, given malignant potential. Pancreatic cyst surgery is associated with significant rates of morbidity and mortality...
  43. Ricci Azevedo R, Gonçales R, Roque Barreira M, Girard D. Human neutrophils are targets to paracoccin, a lectin expressed by Paracoccidioides brasiliensis. Inflamm Res. 2018;67:31-41 pubmed publisher
    Paracoccin (PCN), a lectin expressed by Paracoccidioides brasiliensis (Pb), is known to exert activities on the fungal biology, as well as different immune cells of myeloid origin...
  44. Deng G, Wang Z. Triptycene-Based Microporous Cyanate Resins for Adsorption/Separations of Benzene/Cyclohexane and Carbon Dioxide Gas. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..contain different numbers of benzene rings per molecule were synthesized, from which two microporous cyanate resins PCN-TPC and PCN-TPPC were prepared...
  45. Li T, Lee M, Tsai F, Chen Y, Lin Y, Chen M. Proteomic study revealed antipsychotics-induced nuclear protein regulations in B35 cells are similar to the regulations in C6 cells and rat cortex. BMC Pharmacol Toxicol. 2018;19:9 pubmed publisher
    ..3, histone H4, non-POU domain-containing octamer-binding protein, nucleolin, nucleophosmin, prelamin-A/C, plectin-1, vimentin, and 40S ribosomal protein S3a was regulated by APDs in B35 cells, according to our proteomic data...
  46. Vadivelu P, Suresh C. Computational prediction of cyclometalated Ir(III), Rh(III) and Co(III) amido complexes to capture up to three CO2 molecules. Dalton Trans. 2015;44:16847-53 pubmed publisher
    ..molecules is unprecedented in chemistry while with convincing theoretical evidence we show that [(CH3)2PCH2NH2] (pcn) based cyclometalated Ir(iii), Rh(iii) and Co(iii) amido complexes can perform such a reaction under mild ..
  47. Die Q, Nie Z, Fang Y, Yang Y, Gao X, Tian Y, et al. Seasonal and spatial distributions of atmospheric polychlorinated naphthalenes in Shanghai, China. Chemosphere. 2016;144:2134-41 pubmed publisher
    ..All 75 congeners were quantified and the corresponding toxic equivalents (TEQs) were calculated. PCN concentrations were higher in summer than winter, at 8.22-102 pg/m(3) (average of 61.3 pg/m(3)) in summer and 16...
  48. Töllner T, Conci M, Muller H, Mazza V. Attending to multiple objects relies on both feature- and dimension-based control mechanisms: Evidence from human electrophysiology. Atten Percept Psychophys. 2016;78:2079-89 pubmed publisher
    ..of this response slowing was feature-based and originated from the stage of attentional selection (as indexed by PCN waves), whereas another source was dimension-based and associated with working memory processes (as indexed by P3b ..
  49. Sheng P, Wu F, Tan J, Zhang H, Ma W, Chen L, et al. A CONSTANS-like transcriptional activator, OsCOL13, functions as a negative regulator of flowering downstream of OsphyB and upstream of Ehd1 in rice. Plant Mol Biol. 2016;92:209-22 pubmed publisher
    ..In rice, Heading date1 (Hd1), a homologue of CO, functions in an opposite way, which inhibits flowering under long day conditions and induces ..
  50. Rak A, Zajda K, Gregoraszczuk E. Endocrine disrupting compounds modulates adiponectin secretion, expression of its receptors and action on steroidogenesis in ovarian follicle. Reprod Toxicol. 2017;69:204-211 pubmed publisher
    We determined the effect of dioxin-like polychlorinated naphtalenes (PCN) (Halowax 1051) (100pg/ml), benzo(a)pyrene [B(a)P] (2.5ng/ml), hexachlorobenzene (HCBz) (0...
  51. Wang J, Lo S, Li Y, Chen P, Lin S, Ho T, et al. Ectopic expression of OsMADS45 activates the upstream genes Hd3a and RFT1 at an early development stage causing early flowering in rice. Bot Stud. 2013;54:12 pubmed publisher
    ..We introduce an OsMADS45 overexpression construct Ubi:OsMADS45 into TNG67 plants (an Hd1 (Heading date 1) and Ehd1 (Early heading date 1) defective rice cultivar grown in Taiwan), and we analyzed the ..
  52. Hughes Q, Le B, Gilmore G, Baker R, Veedu R. Construction of a Bivalent Thrombin Binding Aptamer and Its Antidote with Improved Properties. Molecules. 2017;22: pubmed publisher
    ..Two aptamers, HD1 and HD22, that bind to exosites I and II of the human thrombin molecule, respectively, have been extensively ..
  53. Gnesutta N, Mantovani R, Fornara F. Plant Flowering: Imposing DNA Specificity on Histone-Fold Subunits. Trends Plant Sci. 2018;23:293-301 pubmed publisher
    ..Recent publications indicate that CO and its rice homolog HEADING DATE 1 (Hd1) form heterotrimers with the histone-fold subunits of NF-Y to efficiently bind promoter elements in the florigen ..
  54. Blagoev B, Kratchmarova I, Ong S, Nielsen M, Foster L, Mann M. A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. Nat Biotechnol. 2003;21:315-8 pubmed
    ..Many signaling molecules specifically formed complexes with the activated EGFR-Shc, as did plectin, epiplakin, cytokeratin networks, histone H3, the glycosylphosphatidylinositol (GPI)-anchored molecule CD59, and ..
  55. Li C, Renaud H, Klaassen C, Cui J. Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors. Drug Metab Dispos. 2016;44:1038-49 pubmed publisher
    ..TCDD) for AhR; 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP) for CAR; and pregnane-16α-carbonitrile (PCN) for PXR during mouse liver development...
  56. Yuan S, Zou L, Li H, Chen Y, Qin J, Zhang Q, et al. Flexible Zirconium Metal-Organic Frameworks as Bioinspired Switchable Catalysts. Angew Chem Int Ed Engl. 2016;55:10776-80 pubmed publisher
    ..Herein, we designed a flexible Zr-MOF system, namely PCN-700 series, for the realization of switchable catalysis in cycloaddition reactions of CO2 with epoxides...
  57. Sun B, Zhan X, Lin Z, Wu W, Yu P, Zhang Y, et al. Fine mapping and candidate gene analysis of qHD5, a novel major QTL with pleiotropism for yield-related traits in rice (Oryza sativa L.). Theor Appl Genet. 2017;130:247-258 pubmed publisher
    ..Our results also showed that Hd3a, RFT1, Hd1, Ehd1, and Ghd7 were differentially expressed in the two NILs...
  58. Vargas Cruz N, Reitzel R, Rosenblatt J, Jamal M, Szvalb A, Chaftari A, et al. In Vitro Study of Antimicrobial Percutaneous Nephrostomy Catheters for Prevention of Renal Infections. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    Percutaneous nephrostomy (PCN) catheters are the primary method for draining ureters obstructed by malignancy and preventing a decline of renal function...
  59. Maiweilidan Y, Klauza I, Kordeli E. Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C. Exp Cell Res. 2011;317:724-36 pubmed publisher
    ..Here we searched for muscle proteins binding to ankyrin-G OTBD by yeast two hybrid assay, and we found plectin and filamin C, two organizing elements of the cytoskeleton with essential roles in myogenesis, muscle cell ..
  60. Ortega E, Buey R, Sonnenberg A, de Pereda J. The structure of the plakin domain of plectin reveals a non-canonical SH3 domain interacting with its fourth spectrin repeat. J Biol Chem. 2011;286:12429-38 pubmed publisher
    b>Plectin belongs to the plakin family of cytoskeletal crosslinkers, which is part of the spectrin superfamily...
  61. McInroy L, Määttä A. Plectin regulates invasiveness of SW480 colon carcinoma cells and is targeted to podosome-like adhesions in an isoform-specific manner. Exp Cell Res. 2011;317:2468-78 pubmed publisher
    ..b>Plectin is a large cytolinker protein that influences tissue integrity, organisation of actin and intermediate filaments, ..
  62. Burch T, Watson M, Nyalwidhe J. Variable metastatic potentials correlate with differential plectin and vimentin expression in syngeneic androgen independent prostate cancer cells. PLoS ONE. 2013;8:e65005 pubmed publisher
    ..The upregulation of plectin and vimentin which were the most significantly differentially expressed were validated by Western blot and their ..
  63. Ortega E, Manso J, Buey R, Carballido A, Carabias A, Sonnenberg A, et al. The Structure of the Plakin Domain of Plectin Reveals an Extended Rod-like Shape. J Biol Chem. 2016;291:18643-62 pubmed publisher
    Plakins are large multi-domain proteins that interconnect cytoskeletal structures. Plectin is a prototypical plakin that tethers intermediate filaments to membrane-associated complexes...
  64. Cheng C, Lai Y, Lai Y, Chao W, Tseng Y, Hsu Y, et al. Cell Pleomorphism and Cytoskeleton Disorganization in Human Liver Cancer. In Vivo. 2016;30:549-55 pubmed
    ..b>Plectin, a nuclear pore-permeable component of cytoskeleton, exhibits a role of cross-linking between cytoplasmic ..
  65. Cuomo C, Bakkeren G, Khalil H, Panwar V, Joly D, Linning R, et al. Comparative Analysis Highlights Variable Genome Content of Wheat Rusts and Divergence of the Mating Loci. G3 (Bethesda). 2017;7:361-376 pubmed publisher
    ..Two allelic homeodomain pairs, HD1 and HD2, were identified in each dikaryotic Puccinia species along with three pheromone receptor (STE3..
  66. Shellikeri S, Daulton R, Sertic M, Connolly B, Hogan M, Marshalleck F, et al. Pediatric Percutaneous Nephrostomy: A Multicenter Experience. J Vasc Interv Radiol. 2018;29:328-334 pubmed publisher
    To analyze technique, outcomes, and complications of a large series of pediatric percutaneous nephrostomy (PCN) procedures performed at 4 tertiary pediatric centers...
  67. Chavanas S, Pulkkinen L, Gache Y, Smith F, McLean W, Uitto J, et al. A homozygous nonsense mutation in the PLEC1 gene in patients with epidermolysis bullosa simplex with muscular dystrophy. J Clin Invest. 1996;98:2196-200 pubmed
    b>Plectin is a widely expressed cytomatrix component involved in the attachment of the cytoskeleton to the plasma membrane...
  68. Nakano A, Pulkkinen L, Murrell D, Rico J, Lucky A, Garzon M, et al. Epidermolysis bullosa with congenital pyloric atresia: novel mutations in the beta 4 integrin gene (ITGB4) and genotype/phenotype correlations. Pediatr Res. 2001;49:618-26 pubmed
    ..The data on specific mutations in EB-PA patients allows prenatal testing and preimplantation genetic diagnosis in families at risk. ..
  69. Brown M, Hallam J, Liu Y, Yamada K, Shaw S. Cutting edge: integration of human T lymphocyte cytoskeleton by the cytolinker plectin. J Immunol. 2001;167:641-5 pubmed
    ..We demonstrate that human peripheral blood T lymphocytes express plectin, an IF-binding, cytoskeletal cross-linking protein...
  70. Koss Harnes D, Høyheim B, Anton Lamprecht I, Gjesti A, Jørgensen R, Jahnsen F, et al. A site-specific plectin mutation causes dominant epidermolysis bullosa simplex Ogna: two identical de novo mutations. J Invest Dermatol. 2002;118:87-93 pubmed
    b>Plectin is one of the largest and most versatile cytolinker proteins known. In basal keratinocytes it links the intermediate filament network to cell membrane-associated hemidesmosomes...
  71. Urbániková L, Janda L, Popov A, Wiche G, Sevcik J. Purification, crystallization and preliminary X-ray analysis of the plectin actin-binding domain. Acta Crystallogr D Biol Crystallogr. 2002;58:1368-70 pubmed
    b>Plectin is an abundantly expressed cytoskeletal crosslinking protein of enormous size (>500 kDa) and multiple functions. It represents one of the many members of a large family of actin-binding proteins...
  72. Koster J, Geerts D, Favre B, Borradori L, Sonnenberg A. Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly. J Cell Sci. 2003;116:387-99 pubmed
    ..The results show that: (1) bullous pemphigoid antigen (BP) 180 binds not only to BP230, but also to plectin. The interactions between these proteins are facilitated by the Y subdomain in the N-terminal plakin domain of ..
  73. Sonnenberg A, Rojas A, de Pereda J. The structure of a tandem pair of spectrin repeats of plectin reveals a modular organization of the plakin domain. J Mol Biol. 2007;368:1379-91 pubmed
    b>Plectin is a large and versatile cytoskeletal linker and member of the plakin protein family. Plakins share a conserved region called the plakin domain located near their N terminus...
  74. Nery F, Zeng J, Niland B, Hewett J, Farley J, Irimia D, et al. TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton. J Cell Sci. 2008;121:3476-86 pubmed publisher
    ..torsinA and nesprin-3, which spans the outer nuclear membrane (ONM) of the NE and links it to vimentin via plectin in fibroblasts...
  75. Steiner Champliaud M, Schneider Y, Favre B, Paulhe F, Praetzel Wunder S, Faulkner G, et al. BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin. Exp Cell Res. 2010;316:297-313 pubmed publisher
    ..muscle cells, co-localizing with the sarcomeric Z-disc protein alpha-actinin-2 and partially with the cytolinker plectin as well as with the intermediate filament protein desmin...
  76. Mirabella F, Murison A, Aronson L, Wardell C, Thompson A, Hanrahan S, et al. A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex. PLoS ONE. 2014;9:e99493 pubmed publisher
    ..Using RNA-seq we show that REIIBP influences the RNA splicing pattern of the cell. This new discovery provides novel insights into the understanding of MM pathology, and potential new leads for therapeutic targeting. ..
  77. Huber Huber C, Ditye T, Marchante Fernández M, Ansorge U. Using temporally aligned event-related potentials for the investigation of attention shifts prior to and during saccades. Neuropsychologia. 2016;92:129-141 pubmed publisher
    ..This allowed us to study contra-to-ipsilateral ERP differences (such as the N2pc or PCN) that reflect attention shifts to the targets, prior to saccade onset and during saccades...
  78. Zhu S, Wang J, Cai M, Zhang H, Wu F, Xu Y, et al. The OsHAPL1-DTH8-Hd1 complex functions as the transcription regulator to repress heading date in rice. J Exp Bot. 2017;68:553-568 pubmed publisher
    ..physically interact with Days To Heading on chromosome 8 (DTH8), which physically interacts with Heading date 1 (Hd1) both in vitro and in vivo. OsHAPL1 forms a complex with DTH8 and Hd1 in Escherichia coli...
  79. Wang X, Gu W, Guo E, Cui C, Li Y. Assessment of long-range transport potential of polychlorinated Naphthalenes based on three-dimensional QSAR models. Environ Sci Pollut Res Int. 2017;24:14802-14818 pubmed publisher
    Experimentally determined octanol-air partition coefficients (K OA) for 43 polychlorinated naphthalene (PCN) congeners and experimentally determined subcooled liquid vapor pressures (P L) for 17 PCN congeners were ..
  80. Pang J, Yuan S, Du D, Lollar C, Zhang L, Wu M, et al. Flexible Zirconium MOFs as Bromine-Nanocontainers for Bromination Reactions under Ambient Conditions. Angew Chem Int Ed Engl. 2017;56:14622-14626 pubmed publisher
    A series of flexible MOFs (PCN-605, PCN-606, and PCN-700) are synthesized and applied to reversible bromine encapsulation and release...
  81. Foisner R, Traub P, Wiche G. Protein kinase A- and protein kinase C-regulated interaction of plectin with lamin B and vimentin. Proc Natl Acad Sci U S A. 1991;88:3812-6 pubmed
    ..binding assays with protein species purified from cultured rat glioma C6 cells and Ehrlich ascites revealed that plectin bound specifically to lamin B but not to lamins A and C...
  82. Sporstøl M, Tapia G, Malerød L, Mousavi S, Berg T. Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochem Biophys Res Commun. 2005;331:1533-41 pubmed
    ..by the PXR activators rifampicin and lithocholic acid (LCA) in HepG2 cells and pregnenolone 16alpha-carbonitrile (PCN) in primary rat hepatocytes...
  83. Lee K, Liu Y, Ho C, Pei R, Yeh K, Cheng C, et al. An early evaluation of malignant tendency with plectin expression in human colorectal adenoma and adenocarcinoma. J Med. 2004;35:141-9 pubmed
    Tumor cells are morphologically different from normal cells. In this situation, we proposed that plectin, one of the intermediate filament associated proteins, might play some special roles in the tumorigenesis...
  84. Winter L, Abrahamsberg C, Wiche G. Plectin isoform 1b mediates mitochondrion-intermediate filament network linkage and controls organelle shape. J Cell Biol. 2008;181:903-11 pubmed publisher
    b>Plectin is a versatile intermediate filament (IF)-bound cytolinker protein with a variety of differentially spliced isoforms accounting for its multiple functions...
  85. Bhattacharya R, Gonzalez A, DeBiase P, Trejo H, Goldman R, Flitney F, et al. Recruitment of vimentin to the cell surface by beta3 integrin and plectin mediates adhesion strength. J Cell Sci. 2009;122:1390-400 pubmed publisher
    ..Here, we show that IF recruitment to FAs in endothelial cells requires beta3 integrin, plectin and the microtubule cytoskeleton, and is dependent on microtubule motors...
  86. Walker G, Woody M, Orrin E, Mellerio J, Levy M. Epidermolysis Bullosa with Pyloric Atresia and Significant Urologic Involvement. Pediatr Dermatol. 2017;34:e61-e64 pubmed publisher
    ..EB results from a variety of mutations in proteins of the skin and mucous membranes of the body. Mutations in plectin a protein involved in hemidesmosome integrity and function, are associated with subtypes of EB, including EB with ..
  87. Stewart J, Smith T, Kim C. Clinical implications of acute pelvicaliceal hematoma formation during percutaneous catheter nephrostomy insertion. Clin Imaging. 2017;43:180-183 pubmed publisher
    ..the clinical implications of acute pelvicaliceal hematoma formation during percutaneous catheter nephrostomy (PCN) insertion. Collecting system hematoma burden was retrospectively assessed for 694 PCN insertions in 502 patients...
  88. Li S, Cheng H, Qiu W, Zhang L, Wan S, Zeng J, et al. Cancer cell membrane-coated biomimetic platform for tumor targeted photodynamic therapy and hypoxia-amplified bioreductive therapy. Biomaterials. 2017;142:149-161 pubmed publisher
    ..In this work, based on the TPZ-loaded porphyrinic metal organic framework PCN-224 (PCN stands for porous coordination network), a cancer cell membrane-coated nanoplatform (TPZ@PCN@Mem) was ..
  89. Kondor A, Hogan S. Relationships between surface energy analysis and functional characteristics of dairy powders. Food Chem. 2017;237:1155-1162 pubmed publisher
    Surface energetics of demineralised whey (DMW), skimmed milk (SMP), phosphocasein (PCN) and infant milk formula (IMF) powders were determined by inverse gas chromatography (IGC)...
  90. Verma S, Nadagouda M, Varma R. Porous nitrogen-enriched carbonaceous material from marine waste: chitosan-derived carbon nitride catalyst for aerial oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid. Sci Rep. 2017;7:13596 pubmed publisher
    Chitosan-derived, porous nitrogen-enriched carbonaceous carbon nitride catalyst (PCNx) has been synthesized from marine waste and its use demonstrated in a metal-free heterogeneous selective oxidation of 5-hydroxymethyl-..