Gene Symbol: PLCE1
Description: phospholipase C epsilon 1
Alias: NPHS3, PLCE, PPLC, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1, PLC-epsilon-1, pancreas-enriched phospholipase C, phosphoinositide phospholipase C, phosphoinositide phospholipase C-epsilon-1, phosphoinositide-specific phospholipase C epsilon-1
Species: human
Products:     PLCE1

Top Publications

  1. Song C, Hu C, Masago M, Kariyai K, Yamawaki Kataoka Y, Shibatohge M, et al. Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. J Biol Chem. 2001;276:2752-7 pubmed
    ..These results indicate that Ras directly regulates phosphoinositide breakdown through membrane targeting of PLCepsilon. ..
  2. Hinkes B, Wiggins R, Gbadegesin R, Vlangos C, Seelow D, Nurnberg G, et al. Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet. 2006;38:1397-405 pubmed
    ..Using positional cloning, we identified mutations in the phospholipase C epsilon gene (PLCE1) as causing early-onset nephrotic syndrome with end-stage kidney disease...
  3. Mai R, Cheng Y, Huang Y, Zhang G. Esophageal squamous cell carcinoma and gastric cardia adenocarcinoma shared susceptibility locus in PLCE1: a meta-analysis. PLoS ONE. 2013;8:e69214 pubmed publisher
    Two recent genome-wide association studies have identified a shared susceptibility variation PLCE1 rs2274223 for esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinomas (GCA)...
  4. Bourguignon L, Gilad E, Brightman A, Diedrich F, Singleton P. Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells. J Biol Chem. 2006;281:14026-40 pubmed
  5. Zhou R, Li Y, Wang N, Liu B, Chen Z, Zuo L. PLC-ε1 gene polymorphisms significantly enhance the risk of esophageal squamous cell carcinoma in individuals with a family history of upper gastrointestinal cancers. Arch Med Res. 2012;43:578-84 pubmed publisher
  6. Abnet C, Freedman N, Hu N, Wang Z, Yu K, Shu X, et al. A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet. 2010;42:764-7 pubmed publisher
    ..A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34)...
  7. Duan F, Xie W, Cui L, Wang P, Song C, Qu H, et al. Novel functional variants locus in PLCE1 and susceptibility to esophageal squamous cell carcinoma: based on published genome-wide association studies in a central Chinese population. Cancer Epidemiol. 2013;37:647-52 pubmed publisher
    A novel functional single nucleotide polymorphism (SNP) rs2274223 located in the phospholipase C epsilon 1 (PLCE1) gene was found to be associated with the risk of esophageal squamous cell carcinoma (ESCC) by three large-scale genome-..
  8. Lopez I, Mak E, Ding J, Hamm H, Lomasney J. A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway. J Biol Chem. 2001;276:2758-65 pubmed
    ..Our findings demonstrate that PLCepsilon is a novel bifunctional enzyme that is regulated by the heterotrimeric G protein Galpha(12) and activates the small G protein Ras/mitogen-activated protein kinase signaling pathway. ..
  9. Sorli S, Bunney T, Sugden P, Paterson H, Katan M. Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants. Oncogene. 2005;24:90-100 pubmed
    ..Taken together, our findings suggest that regulatory mechanisms controlling expression of PLCepsilon, broadened by diversity introduced by splice variants, could play important role in PLCepsilon regulation in normal and tumor cells. ..

More Information


  1. Ma H, Wang L, Liu Z, Sturgis E, Wei Q. Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck. BMC Cancer. 2011;11:258 pubmed publisher
    Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase family plays crucial roles in carcinogenesis and progression of several cancers, including squamous cell carcinoma of the head and neck (SCCHN)...
  2. Wang X, Zhou C, Qiu G, Yang Y, Yan D, Xing T, et al. Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer. Med Oncol. 2012;29:1051-8 pubmed publisher
    In our previous study, we have found that PLCE1 was down-regulated in sporadic colorectal cancer. But the role of PLCE1 in the incidence of colorectal cancer is still not definite...
  3. Whitehorn J, Chau T, Nguyet N, Kien D, Quyen N, Trung D, et al. Genetic variants of MICB and PLCE1 and associations with non-severe dengue. PLoS ONE. 2013;8:e59067 pubmed publisher
    ..association study (GWAS) identified susceptibility loci for dengue shock syndrome (DSS) at MICB rs3132468 and PLCE1 rs3740360...
  4. Hao N, He Y, Zhang D, Luo G, Chen B, Zhang Y, et al. PLCE1 polymorphism and upper gastrointestinal cancer risk: a meta-analysis. PLoS ONE. 2013;8:e67229 pubmed publisher
    In recent years, the PLCE1 rs2274223 polymorphism has been extensively investigated as a potential risk factor for upper gastrointestinal cancers, including squamous cell carcinoma (ESCC) and gastric cancer...
  5. Bye H, Prescott N, Lewis C, Matejcic M, Moodley L, Robertson B, et al. Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population. Carcinogenesis. 2012;33:2155-61 pubmed publisher
    ..association studies in Chinese populations identified five new OSCC susceptibility loci, including variants at PLCE1, C20orf54, PDE4D, RUNX1 and UNC5CL, but their contribution to disease risk in other populations is unknown...
  6. Zhang X, Zhang Y, Gu D, Cao C, Zhang Q, Xu Z, et al. Increased risk of developing digestive tract cancer in subjects carrying the PLCE1 rs2274223 A>G polymorphism: evidence from a meta-analysis. PLoS ONE. 2013;8:e76425 pubmed publisher
    To date, the association between phospholipase C epsilon 1 (PLCE1) rs2274223 A>G and risk of digestive tract cancer (DTC) remains inconclusive...
  7. Hu H, Yang J, Sun Y, Yang Y, Qian J, Jin L, et al. Putatively functional PLCE1 variants and susceptibility to esophageal squamous cell carcinoma (ESCC): a case-control study in eastern Chinese populations. Ann Surg Oncol. 2012;19:2403-10 pubmed publisher
    A novel variant rs2274223 located in the phospholipase C epsilon 1 (PLCE1) gene was found to be associated with risk of esophageal squamous cell carcinoma (ESCC) by 2 large-scale genome-wide association studies (GWASs) in Chinese ..
  8. Luo D, Gao Y, Wang S, Wang M, Wu D, Wang W, et al. Genetic variation in PLCE1 is associated with gastric cancer survival in a Chinese population. J Gastroenterol. 2011;46:1260-6 pubmed publisher
    ..genome-wide association studies on gastric cancer showed a previously unknown gastric cancer susceptible locus in PLCE1 at 10q23...
  9. Bunney T, Harris R, Gandarillas N, Josephs M, Roe S, Sorli S, et al. Structural and mechanistic insights into ras association domains of phospholipase C epsilon. Mol Cell. 2006;21:495-507 pubmed
    ..Studies of PLCepsilon regulation suggest that, in a cellular context, the RA2 domain, in a mode specific to PLCepsilon, has a role in membrane targeting with further regulatory impact on PLC activity. ..
  10. Wang X, Zbou C, Qiu G, Fan J, Tang H, Peng Z. Screening of new tumor suppressor genes in sporadic colorectal cancer patients. Hepatogastroenterology. 2008;55:2039-44 pubmed
    ..Through the microarray-based high throughput screening, we found 4 significant down-regulated genes: PLCE1, CPEB3, NKX2-3 and SEMA4G. And the down-regulation of PLCE1 was most significant...
  11. Wang Q, Chen P, Chen D, Liu F, Pan W. Association between phospholipase C epsilon gene (PLCE1) polymorphism and colorectal cancer risk in a Chinese population. J Int Med Res. 2014;42:270-81 pubmed publisher
    ..between a single nucleotide polymorphism rs2274223 (adenine [A] to guanine [G]) in the phospholipase C epsilon 1 (PLCE1) gene and susceptibility to colorectal cancer (CRC)...
  12. Dura P, Bregitha C, Te Morsche R, Roelofs H, Kristinsson J, Wobbes T, et al. GWAS-uncovered SNPs in PLCE1 and RFT2 genes are not implicated in Dutch esophageal adenocarcinoma and squamous cell carcinoma etiology. Eur J Cancer Prev. 2013;22:417-9 pubmed publisher
    ..The total EC group included 86 patients with ESCC and 258 patients with EAC. The distribution of PLCE1 and RFT2 genotypes did not differ between patients with EAC or ESSC, and the controls...
  13. Wang M, Zhang R, He J, Qiu L, Li J, Wang Y, et al. Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. PLoS ONE. 2012;7:e31932 pubmed publisher
    ..Recent genome-wide association studies (GWAS) have found a single nucleotide polymorphism (SNP, rs2274223 A>G) in PLCE1 to be associated with risk of gastric adenocarcinoma...
  14. Khor C, Chau T, Pang J, Davila S, Long H, Ong R, et al. Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1. Nat Genet. 2011;43:1139-41 pubmed publisher
    ..34 (95% confidence interval: 1.23-1.46)). We identified associated variants within PLCE1 (phospholipase C, epsilon 1) on chromosome 10 (rs3765524, P(meta) = 3.08 × 10(-10), per-allele OR = 0...
  15. Sharma K, Umar M, Pandey M, Misra S, Kumar A, Kumar V, et al. Association of potentially functional genetic variants of PLCE1 with gallbladder cancer susceptibility in north Indian population. J Gastrointest Cancer. 2013;44:436-43 pubmed publisher
    Phospholipase C epsilon 1 (PLCE1) plays crucial roles in carcinogenesis and progression of esophageal and gastric cancers. In the present study, we investigated association of GWAS identified rs2274223 A>G and...
  16. Malik M, Umar M, Gupta U, Zargar S, Mittal B. Phospholipase C epsilon 1 (PLCE1 rs2274223A>G, rs3765524C>T and rs7922612C>T) polymorphisms and esophageal cancer risk in the Kashmir Valley. Asian Pac J Cancer Prev. 2014;15:4319-23 pubmed
    Phospholipase C epsilon 1 (PLCE1) encodes a member of the phospholipase family of proteins that play crucial roles in carcinogenesis and progression of several cancers including esophageal cancer (EC)...
  17. Zhang Y, Wang R, Zhu L, Zhang S, Yuan H, Jiang H. Meta-analysis of phospholipase C epsilon 1 polymorphism and cancer risk. Cancer Biomark. 2013;13:483-9 pubmed publisher
    Phospholipase C epsilon 1 (PLCE1) plays crucial roles in carcinogenesis and progression of several cancers. A single nucleotide polymorphism (SNP, rs2274223) in PLCE1 has been identified as a novel susceptibility locus...
  18. Jefferson J, Shankland S. Familial nephrotic syndrome: PLCE1 enters the fray. Nephrol Dial Transplant. 2007;22:1849-52 pubmed
  19. Palmer A, Lochhead P, Hold G, Rabkin C, Chow W, Lissowska J, et al. Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populations. Eur J Cancer Prev. 2012;21:541-4 pubmed
    ..associations between upper gastrointestinal cancer and the rs2274223, rs13042395 and rs4072037 polymorphisms in PLCE1, C20orf54 and MUC1, respectively...
  20. Song H, Kim H, Kweon S, Choi J, Shim H, Cho S, et al. Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population. Tumour Biol. 2014;35:3133-7 pubmed publisher
    ..The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population...
  21. Danielsen S, Cekaite L, Ã…gesen T, Sveen A, Nesbakken A, Thiis Evensen E, et al. Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome. PLoS ONE. 2011;6:e24419 pubmed publisher
    ..several members of the Phospholipase C protein family, and the reduced expression of two of these, PLCD1 and PLCE1, were successfully validated in CRC biopsies (n = 70) and cell lines (n = 19) by ..
  22. Gbadegesin R, Hinkes B, Hoskins B, Vlangos C, Heeringa S, Liu J, et al. Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS). Nephrol Dial Transplant. 2008;23:1291-7 pubmed
    ..We recently identified by positional cloning recessive mutations in the gene PLCE1/NPHS3 as a novel cause of IDMS. We demonstrated a role of PLCE1 in glomerulogenesis...
  23. Wu C, Hu Z, He Z, Jia W, Wang F, Zhou Y, et al. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet. 2011;43:679-84 pubmed publisher
    ..92 × 10(-56)). These findings highlight the involvement of multiple genetic loci and gene-environment interaction in the development of esophageal cancer. ..
  24. Gu H, Ding G, Zhang W, Liu C, Chen Y, Chen S, et al. Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population. Mol Biol Rep. 2012;39:9105-11 pubmed publisher
    ..association studies (GWAS) reported that functional genetic variations in the phospholipase C epsilon gene (PLCE1) were strongly associated with risk of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma ..
  25. Wang H, Oestreich E, Maekawa N, Bullard T, Vikstrom K, Dirksen R, et al. Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy. Circ Res. 2005;97:1305-13 pubmed
  26. Jin T, Satoh T, Liao Y, Song C, Gao X, Kariya K, et al. Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling. J Biol Chem. 2001;276:30301-7 pubmed
    ..These results suggest a pivotal role of the CDC25 homology domain in amplifying Rap1-dependent signal transduction, including the activation of PLCepsilon itself, at specific subcellular locations such as the Golgi apparatus. ..
  27. Ou L, Guo Y, Luo C, Wu X, Zhao Y, Cai X. RNA interference suppressing PLCE1 gene expression decreases invasive power of human bladder cancer T24 cell line. Cancer Genet Cytogenet. 2010;200:110-9 pubmed publisher
    Mutational activation of the ras proto-oncogenes is frequently found in cancers. The phospholipase C epsilon gene (PLCE1) encodes a novel ras-related protein (R-Ras) effector mediating the effects of R-Ras on the actin cytoskeleton and ..
  28. Wang L, Zhou F, Li X, Sun L, Song X, Jin Y, et al. Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet. 2010;42:759-63 pubmed publisher
    ..We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5...
  29. Cheng H, Luo C, Wu X, Zhang Y, He Y, Wu Q, et al. shRNA targeting PLC? inhibits bladder cancer cell growth in vitro and in vivo. Urology. 2011;78:474.e7-11 pubmed publisher
    ..The knockdown of PLC? by shRNA could inhibit bladder tumor growth and might be an alternative approach for human bladder cancer therapy. ..
  30. Ramanathan A, Vijayan M, Rajagopal S, Rajendiran P, Senguttuvan P. WT1 and NPHS2 gene mutation analysis and clinical management of steroid-resistant nephrotic syndrome. Mol Cell Biochem. 2017;426:177-181 pubmed publisher
    ..of these children would be a risk with the possibility of mutational changes in podocyte genes (NPHS1, NPHS2, WT1, PLCE1). The mutation in podocyte genes is associated with SRNS...
  31. DiStefano P, Smrcka A, Glading A. Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier. PLoS ONE. 2016;11:e0162338 pubmed publisher
    ..Thus we have described a novel role for PLCε PIP2 hydrolytic and Rap GEF activities in arterial endothelial cells, where PLCε-dependent activation of Rap1/KRIT1 signaling promotes endothelial barrier stability. ..
  32. Cui X, Pang X, Li S, Jin J, Hu J, Yang L, et al. Elevated expression patterns and tight correlation of the PLCE1 and NF-κB signaling in Kazakh patients with esophageal carcinoma. Med Oncol. 2014;31:791 pubmed publisher
    This study investigated the expression of the phospholipase C epsilon 1 (PLCE1) and nuclear factor-kappaB (NF-κB)-related proteins in Kazakh patients with esophageal squamous cell carcinoma (ESCC)...
  33. Duan X, Li X, Lou H, Geng T, Jin T, Liang P, et al. Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with colorectal cancer risk in the Han population. Tumour Biol. 2014;35:1813-7 pubmed publisher
    ..Based on ?(2) tests, PLCE1 -rs2077218, rs11187877 (p?=?0.049) and C11orf92-C11orf93-rs3802842 (p?=?0.023) correlate with CRC risk...
  34. Evellin S, Nolte J, Tysack K, vom Dorp F, Thiel M, Weernink P, et al. Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B. J Biol Chem. 2002;277:16805-13 pubmed
  35. Umar M, Upadhyay R, Mittal B. PLCE1 rs2274223 A>G polymorphism and cancer risk: a meta-analysis. Tumour Biol. 2013;34:3537-44 pubmed
    Phospholipase C epsilon 1 gene (PLCE1) encodes a phospholipase enzyme which regulates various physiological processes (cell growth, differentiation, and apoptosis) and is supposed to play a critical role in carcinogenesis...
  36. Jia X, Liu P, Zhang M, Feng T, Tang H, Tang Z, et al. Genetic variants at 6p21, 10q23, 16q21 and 22q12 are associated with esophageal cancer risk in a Chinese Han population. Int J Clin Exp Med. 2015;8:19381-7 pubmed
    ..We found significant association with risk of EC for five reported SNPs, including rs2274223 in PLCE1 at 10q23 [odds ratio (OR) = 1.390; 95% confidence interval (CI) = 1.075-1...
  37. Hinkes B. NPHS3: new clues for understanding idiopathic nephrotic syndrome. Pediatr Nephrol. 2008;23:847-50 pubmed publisher
    ..identification of autosomal recessive nephrotic syndrome type 3 (NPHS3) caused by mutations in the phospholipase PLCE1 gene has, for the first time, shown steroid responsiveness in H-CHNS...
  38. Cui X, Chen Y, Pang X, Liu W, Hu J, Li S, et al. Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population. Gene. 2013;530:315-22 pubmed publisher
    ..of esophageal squamous cell carcinoma (ESCC) identified a susceptibility locus in phospholipase C epsilon 1 (PLCE1) in Chinese Han populations, few studies further confirmed these findings in pure Kazakh population in which there ..
  39. Cui X, Chen Y, Liu L, Li L, Hu J, Yang L, et al. Heterozygote of PLCE1 rs2274223 increases susceptibility to human papillomavirus infection in patients with esophageal carcinoma among the Kazakh populations. J Med Virol. 2014;86:608-17 pubmed publisher
    ..cancer have identified a shared susceptibility locus at 10q23 (rs2274223: A5780G) in phospholipase C epsilon 1 (PLCE1)...
  40. Umar M, Upadhyay R, Kumar S, Ghoshal U, Mittal B. Role of novel and GWAS originated PLCE1 genetic variants in susceptibility and prognosis of esophageal cancer patients in northern Indian population. Tumour Biol. 2014;35:11667-76 pubmed publisher
    Recent genome-wide association studies (GWAS) have identified variants in phospholipase C epsilon1 (PLCE1) as novel susceptibility markers for esophageal squamous cell carcinoma (ESCC) in Chinese population...
  41. Gormley P, Anttila V, Winsvold B, Palta P, Esko T, Pers T, et al. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet. 2016;48:856-66 pubmed publisher
    ..In subsequent computational analyses, the identified loci showed enrichment for genes expressed in vascular and smooth muscle tissues, consistent with a predominant theory of migraine that highlights vascular etiologies. ..
  42. Du H, Ou L, Yang X, Song X, Fan Y, Tan B, et al. A new PKC?/?/TBX3/E-cadherin pathway is involved in PLC?-regulated invasion and migration in human bladder cancer cells. Cell Signal. 2014;26:580-93 pubmed publisher
    ..In summary, our findings uncover that PKC?/? is critical for PLC?-mediated cancer cell invasion and migration and provide valuable insights for current and future Ad-shPLC? and PKC?/? clinical trials. ..
  43. Gbadegesin R, Bartkowiak B, Lavin P, Mukerji N, Wu G, Bowling B, et al. Exclusion of homozygous PLCE1 (NPHS3) mutations in 69 families with idiopathic and hereditary FSGS. Pediatr Nephrol. 2009;24:281-5 pubmed publisher
    ..Mutations in PLCE1/NPHS3 have recently been reported as a cause of nephrotic syndrome characterized by diffuse mesangial sclerosis (..
  44. Zhao L, Wei Z, Yang C, Chen J, Li D, Ji A, et al. Effects of PLCE1 gene silencing by RNA interference on cell cycling and apoptosis in esophageal carcinoma cells. Asian Pac J Cancer Prev. 2014;15:5437-42 pubmed
    ..The phospholipase C? gene (PLCE1) encodes a novel ras-related protein effector mediating the effects of R-Ras on the actin cytoskeleton and ..
  45. Duan F, Song C, Dai L, Cui S, Zhang X, Zhao X. Novel functional variants locus in PLCE1 and susceptibility to digestive tract cancer in the Chinese population: a meta-analysis. Int J Biol Markers. 2014;29:e301-9 pubmed publisher
    ..association studies (GWAS) have identified a shared susceptibility variation phospholipase C epsilon 1 (PLCE1) rs2274223 for esophageal squamous cell carcinoma (ESCC) and/or gastric cardia adenocarcinomas (GCA) in the ..
  46. Taqi M, Waseem D, Ismatullah H, Haider S, Faisal M. In silico transcriptional regulation and functional analysis of dengue shock syndrome associated SNPs in PLCE1 and MICB genes. Funct Integr Genomics. 2016;16:335-45 pubmed publisher
    Single nucleotide polymorphisms (SNPs) in PLCE1 and MICB genes increase risk for the development of dengue shock syndrome (DSS)...
  47. Liao X, Han C, Qin W, Liu X, Yu L, Zhu G, et al. PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy. Oncotarget. 2017;8:29202-29219 pubmed publisher
    ..The present study investigated the prognostic significance of PLCE1 gene polymorphisms and expression combined with serum α-fetoprotein (AFP) level in hepatitis B virus (HBV)-..
  48. Luo X. Phospholipase C ?-1 inhibits p53 expression in lung cancer. Cell Biochem Funct. 2014;32:294-8 pubmed publisher
    The pathogenesis of lung cancer is to be further investigated. Recent reports indicate that phospholipase C ?-1 (PLCE1) is a critical molecule involved in tumour growth...
  49. Ye S, Zhao X, Hu X, Li T, Xu Q, Yang H, et al. TP53 and RET may serve as biomarkers of prognostic evaluation and targeted therapy in hepatocellular carcinoma. Oncol Rep. 2017;37:2215-2226 pubmed publisher
    ..The most frequent mutations were: TP53 (20%), RET (6%), PLCE1 (5%), PTEN (4%) and VEGFR2 (3%). Patients with mutations in TP53 had a lower overall survival (OS) (P=0...
  50. Li Y, An J, Huang S, Liao H, Weng Y, Cai S, et al. PLCE1 suppresses p53 expression in esophageal cancer cells. Cancer Invest. 2014;32:236-40 pubmed publisher
    ..This study aims to investigate the role of phospholipase C epsilon 1 (PLCE1) in modulating the apoptosis mechanism in esophageal cancer (Eca) cells...
  51. Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, et al. Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. Eur J Immunol. 1995;25:2695-700 pubmed
    ..The relevance of these findings for a better understanding of the biological functions of extracellular Tat is discussed. ..
  52. Baskin E, Selda Bayrakci U, Alehan F, Ozdemir H, Oner A, Horvath R, et al. Respiratory-chain deficiency presenting as diffuse mesangial sclerosis with NPHS3 mutation. Pediatr Nephrol. 2011;26:1157-61 pubmed publisher
    ..Percutaneous renal biopsy revealed diffuse mesangial sclerosis, and mutational analysis was compatible with PLCE1 mutation...
  53. Du H, Ou L, Song X, Fan Y, Yang X, Tan B, et al. Nuclear factor-?B signaling pathway is involved in phospholipase C?-regulated proliferation in human renal cell carcinoma cells. Mol Cell Biochem. 2014;389:265-75 pubmed publisher
    ..Taken together, these findings suggest that PLC? promotes RCC cell growth via NF-?B-mediated upregulation of VEGF. ..
  54. Wang J, Lin L, Wang H, Chen N. PLCE1 rs2274223 polymorphism contributes to risk of esophageal cancer: evidence based on a meta-analysis. Tumour Biol. 2014;35:6925-31 pubmed publisher
    We sought to reassess the association of PLCE1 rs2274223 and susceptibility to esophageal cancer (EC) through a meta-analysis of published case-control studies...
  55. Liu X, Zhang X, Wang Z, Chang J, Wu Z, Zhang Z, et al. Genetic polymorphism of the phospholipase C epsilon 1 gene and risk of gastric cancer. Chin Med J (Engl). 2014;127:2511-7 pubmed
    ..Recently, two genome-wide association studies found that phospholipase C epsilon 1 (PLCE1) polymorphisms might be related to GC risk, and several studies further validated this finding...
  56. Xue W, Zhu M, Wang Y, He J, Zheng L. Association between PLCE1 rs2274223 A > G polymorphism and cancer risk: proof from a meta-analysis. Sci Rep. 2015;5:7986 pubmed publisher
    Phospholipase C epsilon 1 (PLCE1) plays an important role in cell growth, differentiation and oncogenesis...
  57. Zhai S, Liu C, Zhang L, Zhu J, Guo J, Zhang J, et al. PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail. Neoplasia. 2017;19:154-164 pubmed publisher
    ..Multiple studies with large clinic-based cohorts revealed that variations of the phospholipase C epsilon (PLCE1) gene were associated with esophageal cancer susceptibility...
  58. Kupcinskas J, Gyvyte U, Bruzaite I, Leja M, Kupcinskaite Noreikiene R, Pauzas H, et al. Common Genetic Variants of PSCA, MUC1 and PLCE1 Genes are not Associated with Colorectal Cancer. Asian Pac J Cancer Prev. 2015;16:6027-32 pubmed
    Polymorphisms of genes encoding PSCA, PLCE1 and MUC1 have been associated with the risk of different cancers in genome wide association studies (GWAS)...
  59. Alliey Rodriguez N, Zhang D, Badner J, Lahey B, Zhang X, Dinwiddie S, et al. Genome-wide association study of personality traits in bipolar patients. Psychiatr Genet. 2011;21:190-4 pubmed publisher
    ..036) in PLCE1 gene...
  60. Han N, Zhao W, Zhang Z, Zheng P. MiR-328 suppresses the survival of esophageal cancer cells by targeting PLCE1. Biochem Biophys Res Commun. 2016;470:175-180 pubmed publisher
    ..Dual-luciferase reporter assay confirmed that miR-328 directly targeted phospholipase C epsilon 1 (PLCE1) by binding to target sequences in the 3'-UTR...
  61. Whitehorn J, Kien D, Quyen N, Wills B, Van Vinh Chau N, Tam D, et al. Genetic variants of MICB and PLCE1 and associations with the laboratory features of dengue. BMC Infect Dis. 2017;17:412 pubmed publisher
    A previous genome-wide association study identified 2 susceptibility loci for severe dengue at MICB rs3132468 and PLCE1 rs3740360 and further work showed these mutations to be also associated with less severe clinical presentations...
  62. Cai S, Sun P, Resaul J, Shi L, Jiang A, Satherley L, et al. Expression of phospholipase C isozymes in human breast cancer and their clinical significance. Oncol Rep. 2017;37:1707-1715 pubmed publisher
    ..These isozymes have certain implications in the disease development and progression, with PLC-? showing a significant correlation with shorter disease-free survival. ..
  63. Chan J, Katan M. PLC? and the RASSF family in tumour suppression and other functions. Adv Biol Regul. 2013;53:258-79 pubmed publisher
  64. Boyer O, Benoit G, Gribouval O, Nevo F, Pawtowski A, Bilge I, et al. Mutational analysis of the PLCE1 gene in steroid resistant nephrotic syndrome. J Med Genet. 2010;47:445-52 pubmed publisher
    Mutations in the PLCE1 gene encoding phospholipase C epsilon 1 (PLCepsilon1) have been recently described in patients with early onset nephrotic syndrome (NS) and diffuse mesangial sclerosis (DMS)...
  65. Yang X, Ou L, Tang M, Wang Y, Wang X, Chen E, et al. Knockdown of PLCε inhibits inflammatory cytokine release via STAT3 phosphorylation in human bladder cancer cells. Tumour Biol. 2015;36:9723-32 pubmed publisher
    ..Our results suggested that STAT3 phosphorylation is involved in PLCε-mediated inflammatory cytokine release. Our research is of potential importance in drug development programs using PLCε as a therapeutic target for TCCB. ..
  66. Bijli K, Fazal F, Slavin S, Leonard A, Grose V, Alexander W, et al. Phospholipase C-ε signaling mediates endothelial cell inflammation and barrier disruption in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2016;311:L517-24 pubmed publisher
    ..These data identify PLC-ε as a novel regulator of EC inflammation and permeability and show a hitherto unknown role of PLC-ε in the pathogenesis of ALI. ..
  67. Liu J, Wang T, Zhao M. Genome-Wide Association Mapping for Female Infertility in Inbred Mice. G3 (Bethesda). 2016;6:2929-35 pubmed publisher
    ..The second SNP rs30415957 resides in the intron of Plce1 (phospholipase C epsilon 1)...
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    ..Hence T cell activation can be critically regulated by the Ras effector pathway independent from Raf that can be mimicked by phospholipase C epsilon. ..
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    Esophageal cancer is the sixth leading cause of cancer-associated death worldwide. Phospholipase C epsilon 1 (PLCE1) gene was found to be associated with the risk of esophageal squamous cell carcinoma (ESCC) by three large-scale genome-..
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    ..the role of PLC? in Ras-driven cancers, we generated two new mouse strains: one carrying a targeted deletion of Plce (Plce(-/-)) and the other carrying mutant alleles of Plce unable to bind to Ras (Plce(RAm/RAm))...
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    ..Together these data support a model where c-Src phosphorylates the receptor, thereby creating docking sites for SH2 domain containing proteins, leading to recruitment of Crk to the receptor. ..
  72. Li W, Hu N, Burton V, Yang H, Su H, Conway C, et al. PLCE1 mRNA and protein expression and survival of patients with esophageal squamous cell carcinoma and gastric adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2014;23:1579-1588 pubmed publisher
    Germline genetic variants in PLCE1 (10q23) have demonstrated consistent associations with risk of esophageal squamous cell carcinoma (ESCC) and gastric cancer among Chinese...
  73. Yun S, Möller A, Chae S, Hong W, Bae Y, Bowtell D, et al. Siah proteins induce the epidermal growth factor-dependent degradation of phospholipase Cepsilon. J Biol Chem. 2008;283:1034-42 pubmed
    ..Our results suggest that the Siah-dependent degradation of PLCepsilon plays a role in the regulation of growth factor-dependent cell growth. ..
  74. Guo L, Yang N, Hu D, Zhao X, Feng B, Zhang Y, et al. PLCE1 rs2274223 polymorphism and susceptibility to esophageal cancer: a meta-analysis. Asian Pac J Cancer Prev. 2014;15:9107-12 pubmed
    To investigate and study the relationship between the PLCE1 rs2274223 gene polymorphism and susceptibility to esophageal cancer by meta-analysis...