Research Topics
Genomes and Genes
| PLCB2SummaryGene Symbol: PLCB2 Description: phospholipase C, beta 2 Alias: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2, PLC-beta-2, phosphoinositide phospholipase C-beta-2, phospholipase C-beta-2 Species: human Top Publications
Research Grants
| Scientific Experts
|
Detail Information
Publications
Mechanosensitivity of human osteosarcoma cells and phospholipase C beta2 expressionM Hoberg
Department of Orthopaedics, University of Tuebingen, Germany
Biochem Biophys Res Commun 333:142-9. 2005..Fluid shear flow experiments with MG-63 lacking PLC beta2 revealed a significantly higher level of cells losing attachment to coverslips and a significantly lower number of cells increasing intracellular free calcium...- Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulatorG Berstein
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041
Cell 70:411-8. 1992..Such GAP activity by an effector coupled to a trimeric G protein can reconcile slow GTP hydrolysis by pure G proteins in vitro with fast physiologic deactivation of G protein-mediated signaling... - Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disabilityD W Morris
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 129:97-103. 2004..Both were phospholipase genes, phospholipase C beta 2 (PLCB2) and phospholipase A2, group IVB (cytosolic; PLA2G4B). D15S944 is located within PLCB2 and is 1... - Phospholipase Cbeta2 binds to and inhibits phospholipase Cdelta1Yuanjian Guo
Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
J Biol Chem 280:1438-47. 2005..These results support a model in which PLCbeta2 suppresses the basal catalytic activity of PLCdelta1, which is relieved by binding of Gbetagamma subunits to PLCbeta2 allowing for amplified calcium signals... - Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2Tabetha M Bonacci
Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, New York 14642, USA
J Biol Chem 280:10174-81. 2005.... - Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influxBidhan C Bandyopadhyay
Secretory Physiology Section, Gene Therapy and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 280:12908-16. 2005..These data demonstrate functional localization of TRPC3/TRPC6 channels in the apical region of polarized epithelial cells. In salivary gland ducts this could contribute to the regulation of salivary [Ca2+] and secretion... - PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarraysValeria Bertagnolo
Signal Transduction Unit, Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
Int J Oncol 28:863-72. 2006..Our data indicate that PLC-beta2 expression correlates highly with breast cancer malignancy and suggest that it can be included, as an independent marker, among the prognostic indicators in current use... - Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cellsValeria Bertagnolo
Signal Transduction Unit, Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University G D Annunzio Chieti Pescara, Chieti, Italy
Carcinogenesis 28:1638-45. 2007..On the basis of these data, PLC-beta2 may constitute a molecular marker of breast tumor cells able to monitor the progression to invasive cancers and a target for novel therapeutic breast cancer strategies... - PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursorsFederica Brugnoli
Signal Transduction Unit, Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
Cell Signal 19:1701-12. 2007.... - Alternative splice variants of phospholipase C-beta2 are expressed in platelets: effect on Galphaq-dependent activation and localizationLiansheng Sun
Sol Sherry Thrombosis Research Center, Philadelphia, PA 19140, USA
Platelets 18:217-23. 2007..In transfected CV-1 cells, PLC-beta2a is relatively more enriched in the nuclei than PLC-beta2b suggesting that the two variants may have different effects in cell proliferation and differentiation... - Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stressTomoko Kawai
Department of Stress Science, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, Japan
Biol Psychol 76:147-55. 2007..Of the 24 genes, real-time PCR validated changes in mRNA levels of 10 (PLCB2, CSF3R, ARHGEF1, DPYD, CTNNB1, PPP3CA, POLM, IRF3, TP53, and CCNI)... 
Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCbeta2 axisYong Sun Maeng
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea
Blood 113:233-43. 2009..The utilization of the IGF2/IGF2R system may therefore be useful for the development of novel means to treat angiogenesis-dependent diseases...- Revisiting Libman-Sacks endocarditis: a historical review and updateJennifer L Lee
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
Clin Rev Allergy Immunol 36:126-30. 2009..Improvements in imaging modalities, particularly in echocardiography, have allowed better estimation of the prevalence of the disease, but further investigation is still needed into its pathogenesis, treatment, and association with APS... 
Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent mannerJolanta Idkowiak-Baldys
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
J Biol Chem 284:22322-31. 2009..Taken together, these results demonstrate a novel role for sustained receptor stimulation in regulation of intracellular trafficking, and this process requires sustained stimulation of PKC and PLD...- Differential regulation of phospholipase C-beta2 activity and membrane interaction by Galphaq, Gbeta1gamma2, and Rac2Orit Gutman
Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
J Biol Chem 285:3905-15. 2010..Finally, activation by betagamma recruits PLCbeta(2) to the membrane by transient interactions, leading to fast "surfing" diffusion along the membrane, sampling large regions for dispersed PtdInsP(2) populations... - The small G protein Rac1 activates phospholipase Cdelta1 through phospholipase Cbeta2Yuanjian Guo
Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York 11794 8661, USA
J Biol Chem 285:24999-5008. 2010..Through PLCbeta2, PLCdelta1 activation is linked to surface receptors as well as signals that mediate cytoskeletal pathways... - Association between common variation in genes encoding sweet taste signaling components and human sucrose perceptionAlexey A Fushan
National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
Chem Senses 35:579-92. 2010..Collectively, GNAT3 polymorphisms explain 13% of the variation in sucrose perception. Our findings underscore the importance of common genetic variants influencing human taste perception... - The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common siteYuanjian Guo
Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
J Biol Chem 278:29995-30004. 2003Mammalian inositol-specific phospholipase C-beta2 (PLC beta 2) and PLC delta 1 differ in their cellular activators... - The pleckstrin homology domain of phospholipase C-beta2 as an effector site for RacJason T Snyder
Department of Pharmacology, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 278:21099-104. 2003..Together, these findings present a quantitative evaluation of the direct interactions between Rac GTPases and PLC-beta isozymes and define a novel role for the PH domain of PLC-beta2 as a putative effector site for Rac GTPases... - Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2D Park
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 267:16048-55. 1992..see also accompanying article (Lee, C. H., Park, D., Wu, D., Rhee, S. G., and Simon, M. I. (1992) J. Biol. Chem. 267, 16044-16047)... - Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathwayD Cefai
Laboratoire d Immunologie Cellulaire et Tissulaire, Group Hospitalier GH Pitié Salpétrière, Paris, France
J Clin Invest 86:2117-24. 1990.... - Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human plateletsY Banno
Department of Biochemistry, Gifu University School of Medicine, Japan
J Biol Chem 263:11459-65. 1988..The mPLC-I and mPLC-II activities were increased by Ca2+, but not by Mg2+, while Hg2+, Fe2+, Cu2+, and La3+ were inhibitory. GTP-binding proteins (Gi, Go, and Ki-ras protein) had no significant effects on the mPLC-II activity... - Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell lineG Zauli
Institute of Human Anatomy, University of Ferrara, Italy
Eur J Immunol 25:2695-700. 1995..The relevance of these findings for a better understanding of the biological functions of extracellular Tat is discussed... - Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptorA M Buhl
Department of Chemistry, Aarhus University, Denmark
J Biol Chem 270:19828-32. 1995..These results demonstrate that two independent signals are required for the maximal activation of MAP kinase by G protein-coupled receptors... - Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptorE Dare
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
J Mol Endocrinol 21:7-17. 1998..PLCdelta2, showing predominantly nuclear localization in the parathyroid, was the sole PI-PLC isozyme with higher levels of expression in CaR-transfected HEK cells... - Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridizationS H Park
Institute of Human Genetics, Department of Anatomy, College of Medicine, Korea University, Seoul (South Korea
Cytogenet Cell Genet 83:48-9. 1998 - Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tatN J Haughey
Department of Pharmacology and Therapeutics, University of Manitoba Faculty of Medicine, Winnipeg, Canada
J Neurochem 73:1363-74. 1999.... - Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERFY Tang
Neurobiotechnology Center and Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 275:37559-64. 2000..The interaction with the PDZ protein may constitute an important mechanism for distribution and regulation of store-operated channels... - Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)A Caricasole
Biology Department, GlaxoWellcome Medicines Research Centre, Verona, Italy
Biochim Biophys Acta 1517:63-72. 2000..Finally, we characterized the structure of the PLC beta 1 locus and confirmed its mapping to human chromosome 20... - A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha qAlex U Singer
Department of Pharmacology, The University of North Carolina at Chapel Hill, North Carolina 27599, USA
Nat Struct Biol 9:32-6. 2002..Effector dimerization, as highlighted by PLC-betas, provides a viable mechanism for regulating signaling cascades linked to heterotrimeric G proteins... - The TRPM7 channel is inactivated by PIP(2) hydrolysisLoren W Runnels
Howard Hughes Medical Institute, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, MA 02115, USA
Nat Cell Biol 4:329-36. 2002..We conclude that receptor-mediated activation of PLC results in the hydrolysis of localized PIP(2), leading to inactivation of the TRPM7 channel... - Regulation of the lateral association of phospholipase Cbeta2 and G protein subunits by lipid raftsSuzanne Scarlata
Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
Biochemistry 41:7092-9. 2002..These results suggest a model in which lipid rafts occlude the PLCbeta2 interaction site on Gbetagamma subunits by localizing these subunits at the domain interface... - Selective up-regulation of phospholipase C-beta2 during granulocytic differentiation of normal and leukemic hematopoietic progenitorsValeria Bertagnolo
Signal Transduction Unit Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, Italy
J Leukoc Biol 71:957-65. 2002..Moreover, PLC-beta2 levels can predict the in vivo responsiveness to ATRA of APL patients... - Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3Alastair J Barr
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Biochem Biophys Res Commun 293:647-52. 2002..p38MAPK also co-immunoprecipitated with PLC-beta 2. The data suggest that PLC-beta 2 serves an unappreciated role assembling components of the p38MAPK signaling module... - Role of dynamic interactions in effective signal transfer for Gbeta stimulation of phospholipase C-beta 2Elizabeth Buck
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
J Biol Chem 277:49707-15. 2002.... - Evaluation of conserved and ultra-conserved non-genic sequences in chromosome 15q15-linked periodic catatoniaDenny Schanze
Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
Am J Med Genet B Neuropsychiatr Genet 159:77-86. 2012..Further CNGs were identified at the PLCB2 and DLL4 locus or located intergenic between TYRO3 and MAPKBP1...
Research Grants
- Molecular Basis of Taste Cell SignalingNirupa Chaudhari; Fiscal Year: 2009..our hypothesis on output cells, We will employ mice in which functional cell lineages for cells (a) that express PLCb2 or (b) that synthesize biogenic amines are transgenically labeled with Green Fluorescent Protein (GFP) or b-..
- Molecular Basis of Taste Cell SignalingNirupa Chaudhari; Fiscal Year: 2007..our hypothesis on output cells, We will employ mice in which functional cell lineages for cells (a) that express PLCb2 or (b) that synthesize biogenic amines are transgenically labeled with Green Fluorescent Protein (GFP) or b-..
- MOLECULAR BASIS AND FUNCTION OF SIGNAL TRANSDUCTIONDianqing Wu; Fiscal Year: 2000..mice models to explore the physiological roles of two leukocyte-specific signaling molecules: PI-PLC-beta-2 (PLCb2) and the interleukin-8 receptor (IL-8R)...