platelet activating factor receptor


Gene Symbol: platelet activating factor receptor
Description: platelet activating factor receptor
Alias: PAFR, platelet-activating factor receptor, PAF-R
Species: human

Top Publications

  1. Ye R, Prossnitz E, Zou A, Cochrane C. Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. Biochem Biophys Res Commun. 1991;180:105-11 pubmed
    ..Expression of the cloned cDNA in undifferentiated HL-60 cells devoid of endogenous PAF receptor resulted in specific and saturable binding of the PAF antagonist WEB 2086 with a dissociation constant of 30.7 nM. ..
  2. Cundell D, Gerard N, Gerard C, Idanpaan Heikkila I, Tuomanen E. Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature. 1995;377:435-8 pubmed
    ..This progression could be arrested in vitro and in vivo by PAF-receptor-specific antagonists, suggesting a possible approach to therapy. ..
  3. Haribabu B, Zhelev D, Pridgen B, Richardson R, Ali H, Snyderman R. Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage. J Biol Chem. 1999;274:37087-92 pubmed
    ..responses activated, receptors for the chemoattractants formyl peptides (FR), platelet-activating factor (PAFR), and leukotriene B(4) (BLTR) were transfected into RBL-2H3 cells...
  4. Marques S, Dy L, Southall M, Yi Q, Smietana E, Kapur R, et al. The platelet-activating factor receptor activates the extracellular signal-regulated kinase mitogen-activated protein kinase and induces proliferation of epidermal cells through an epidermal growth factor-receptor-dependent pathway. J Pharmacol Exp Ther. 2002;300:1026-35 pubmed
    ..In summary, these studies provide a mechanism whereby the PAF-R can exert proliferative effects through the activation of the EGF-R. ..
  5. Kitagawa D, Taketomi A, Kayashima H, Kuroda Y, Itoh S, Yamashita Y, et al. Expression of platelet-activating factor receptor: a novel prognosticator in patients with hepatocellular carcinoma following hepatectomy. Oncology. 2007;72:381-7 pubmed publisher
    ..In this study, PAF receptor (PAFR) expression was examined in hepatoma cell lines (Huh7, PLC/PRF/5 and HepG2) and clinical samples of HCC (n = 60) ..
  6. Aponte M, Jiang W, Lakkis M, Li M, Edwards D, Albitar L, et al. Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer. Cancer Res. 2008;68:5839-48 pubmed publisher
    ..However, PAF, with its receptor (PAFR) and their downstream signaling targets, has not been thoroughly studied in cancer...
  7. Poisson C, Rollin S, Veronneau S, Bousquet S, Larrivée J, Le Gouill C, et al. Caveolae facilitate but are not essential for platelet-activating factor-mediated calcium mobilization and extracellular signal-regulated kinase activation. J Immunol. 2009;183:2747-57 pubmed publisher
    ..A potential binding site for caveolin-1 is present in the platelet-activating factor receptor (PAFR) sequence, and many downstream signaling components of PAFR activation preferentially localize in caveolae...
  8. Melnikova V, Balasubramanian K, Villares G, Dobroff A, Zigler M, Wang H, et al. Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis. J Biol Chem. 2009;284:28845-55 pubmed publisher
    ..MUC18), a critical marker of melanoma metastasis, via activation of platelet-activating factor receptor (PAFR) and cAMP-responsive element-binding protein (CREB)...
  9. Shin S, Song H, Kim M, Do E, Kim K, Kim J. Platelet-activating factor receptor mediates oxidized low density lipoprotein-induced migration of bone marrow-derived mesenchymal stem cells. Cell Physiol Biochem. 2010;26:689-98 pubmed publisher
    ..Taken together, these results suggest that PAF plays a pivotal role in the oxLDL-induced recruitment of hBMSCs through mechanisms involving PAF-R-dependent activation of MAPKs. ..

More Information

Publications130 found, 100 shown here

  1. Li T, Southall M, Yi Q, Pei Y, Lewis D, Al Hassani M, et al. The epidermal platelet-activating factor receptor augments chemotherapy-induced apoptosis in human carcinoma cell lines. J Biol Chem. 2003;278:16614-21 pubmed
    ..These studies provide evidence for a novel pathway whereby the epidermal PAF-R can augment chemotherapy-induced apoptotic effects through an NF-kappaB-dependent process. ..
  2. Deo D, Bazan N, Hunt J. Activation of platelet-activating factor receptor-coupled G alpha q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cells. J Biol Chem. 2004;279:3497-508 pubmed
    ..Clearly, PAF-mediated signaling in differentiated endothelial cells is critical to endothelial cell functions, including cell migration and proteolytic activation of MMP2. ..
  3. Zhang L, Wang D, Jiang W, Edwards D, Qiu W, Barroilhet L, et al. Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium. Reprod Biol Endocrinol. 2010;8:74 pubmed publisher
    ..Co-immune precipitation revealed that elevated PAFR expression is associated with protein-protein interactions of PAFR-FAK and FAK-STAT1 in BRCA1-mutant ovarian ..
  4. Sahu R, Rezania S, Ocana J, DaSilva Arnold S, Bradish J, Richey J, et al. Topical application of a platelet activating factor receptor agonist suppresses phorbol ester-induced acute and chronic inflammation and has cancer chemopreventive activity in mouse skin. PLoS ONE. 2014;9:e111608 pubmed publisher
    ..These data provide additional evidence that PAF-R activation exerts complex immunomodulatory effects in a model of chronic inflammation that is relevant to neoplastic development. ..
  5. Moustaka K, Maleskou E, Lambrianidou A, Papadopoulos S, Lekka M, Trangas T, et al. Docosahexaenoic Acid Inhibits Proliferation of EoL-1 Leukemia Cells and Induces Cell Cycle Arrest and Cell Differentiation. Nutrients. 2019;11: pubmed publisher
    ..DHA is a natural substance and the understanding of its action on EoL-1 cells on molecular level could be useful in further investigation as a future therapeutic tool against F/P ⁺ hypereosinophilic syndrome. ..
  6. Birkl D, Quirós M, García Hernández V, Zhou D, Brazil J, Hilgarth R, et al. TNFα promotes mucosal wound repair through enhanced platelet activating factor receptor signaling in the epithelium. Mucosal Immunol. 2019;: pubmed publisher
    ..this report, we show that TNFα promotes intestinal mucosal repair through upregulation of the GPCR platelet activating factor receptor (PAFR) in the intestinal epithelium...
  7. Lingappa J, Dumitrescu L, Zimmer S, Lynfield R, McNicholl J, Messonnier N, et al. Identifying host genetic risk factors in the context of public health surveillance for invasive pneumococcal disease. PLoS ONE. 2011;6:e23413 pubmed publisher
  8. Yao B, Liu B, Shi L, Li X, Ren C, Cai M, et al. PAFR selectively mediates radioresistance and irradiation-induced autophagy suppression in prostate cancer cells. Oncotarget. 2017;8:13846-13854 pubmed publisher
    Platelet-activating factor receptor (PAFR) promotes tumorigenesis, angiogenesis and metastasis...
  9. Reynaud S, Malissein E, Donnard M, Bordessoule D, Turlure P, Trimoreau F, et al. Functional platelet-activating factor receptors in immature forms of leukemic blasts. Leuk Res. 2007;31:399-402 pubmed
    ..In conclusion, functional PAF-R are present in blast cells of patients with acute leukemia; a result that could be of physiologic importance regarding the important effect of PAF on leukocytes maturation and functions. ..
  10. Greiller C, Suri R, Jolliffe D, Kebadze T, Hirsman A, Griffiths C, et al. Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells. J Steroid Biochem Mol Biol. 2019;187:152-159 pubmed publisher
    ..that acts as the cellular receptor for major group rhinoviruses) and platelet-activating factor receptor (PAFR, a G-protein coupled receptor implicated in adhesion of Streptococcus pneumoniae to respiratory epithelial cells)...
  11. Yin X, Chen Z, Zhu X, Hu J. Loss of PAFR prevents neuroinflammation and brain dysfunction after traumatic brain injury. Sci Rep. 2017;7:40614 pubmed publisher
    ..The morphological and behavioral abnormalities after TBI in wild type mice are rescued by general knockout of PAFR gene that neuroinflammation responses and cognitive ability are improved...
  12. da Silva Junior I, Stone S, Rossetti R, Jancar S, Lepique A. Modulation of Tumor-Associated Macrophages (TAM) Phenotype by Platelet-Activating Factor (PAF) Receptor. J Immunol Res. 2017;2017:5482768 pubmed publisher
    ..The biological effects of PAF are mediated by the PAF receptor (PAFR), which can be expressed by tumor cells and host cells that infiltrate the tumor microenvironment...
  13. Gao T, Yu Y, Cong Q, Wang Y, Sun M, Yao L, et al. Human mesenchymal stem cells in the tumour microenvironment promote ovarian cancer progression: the role of platelet-activating factor. BMC Cancer. 2018;18:999 pubmed publisher
    ..We previously determined that platelet-activating factor receptor (PAFR) was overexpressed in ovarian cancer cells (OCCs) and that PAF can promote ovarian cancer progression via PAF/PAFR-..
  14. Liu Y, Shields L, Gao Z, Wang Y, Zhang Y, Chu T, et al. Current Understanding of Platelet-Activating Factor Signaling in Central Nervous System Diseases. Mol Neurobiol. 2017;54:5563-5572 pubmed publisher
    ..exacerbates the inflammatory response and pathological consequences, while application of PAF inhibitors or PAFR antagonists by blocking this signaling pathway significantly reduces inflammation, protects cells, and improves the ..
  15. Dyer K, Percopo C, Xie Z, Yang Z, Kim J, Davoine F, et al. Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor. J Immunol. 2010;184:6327-34 pubmed publisher
    ..promote degranulation (release of eosinophil peroxidase) via a mechanism that is independent of the characterized PAFR. Specifically, we demonstrate that receptor antagonists CV-3988 and WEB-2086 and pertussis toxin have no impact on ..
  16. Lou C, Lu H, Ma Z, Liu C, Zhang Y. Ginkgolide B enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR/NF-кB pathway. Biomed Pharmacother. 2019;109:563-572 pubmed publisher
    ..Gemcitabine could upregulate PAFR and phosphorylated NF-кB/p65 expression, and increase NF-кB activity, but this was largely suppressed in ..
  17. Shukla S. Platelet-activating factor receptor and signal transduction mechanisms. FASEB J. 1992;6:2296-301 pubmed
    ..These recent developments throw light on the PAF receptor and its signal transduction mechanisms. ..
  18. Marathe G, Johnson C, Billings S, Southall M, Pei Y, Spandau D, et al. Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage. J Biol Chem. 2005;280:35448-57 pubmed
    ..PAF signaling may participate in the cutaneous inflammation that occurs during photo-aggravated dermatoses. ..
  19. Marentette J, Kolar G, McHowat J. Increased susceptibility to bladder inflammation in smokers: targeting the PAF-PAF receptor interaction to manage inflammatory cell recruitment. Physiol Rep. 2015;3: pubmed publisher
    ..cell adherence to bladder endothelial cells and if targeting the platelet-activating factor (PAF)-PAF receptor (PAFR) interaction could be beneficial in managing bladder inflammation...
  20. Vilela M, Lima G, Rodrigues D, Lacerda Queiroz N, Pedroso V, de Miranda A, et al. Platelet Activating Factor (PAF) Receptor Deletion or Antagonism Attenuates Severe HSV-1 Meningoencephalitis. J Neuroimmune Pharmacol. 2016;11:613-621 pubmed
    ..We aimed to investigate the activation of PAF receptor (PAFR) and its contribution to the severity of the inflammatory response in the brain following HSV-1 infection...
  21. Ishizuka E, Filgueiras L, Rios F, Serezani C, Jancar S. PAFR activation of NF-?B p65 or p105 precursor dictates pro- and anti-inflammatory responses during TLR activation in murine macrophages. Sci Rep. 2016;6:32092 pubmed publisher
    Platelet-activating factor receptor (PAFR) is a G protein-coupled receptor (GPCR) implicated in many diseases. Toll-like receptors (TLRs) play a critical role in shaping innate and adaptive immune responses...
  22. Shivshankar P, Boyd A, Le Saux C, Yeh I, Orihuela C. Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia. Aging Cell. 2011;10:798-806 pubmed publisher
    ..young controls. Keratin 10 (K10), laminin receptor (LR), and platelet-activating factor receptor (PAFr), host proteins known to be co-opted for bacterial adhesion, were also increased...
  23. Chen J, Lan T, Zhang W, Dong L, Kang N, Zhang S, et al. Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer. Cancer Res. 2015;75:4198-210 pubmed publisher
    Platelet-activating factor receptor (PAFR), a G-protein-coupled receptor, has been implicated in tumorigenesis, but its contributions to metastatic progression have not been investigated...
  24. Yu Y, Zhang M, Zhang X, Cai Q, Zhu Z, Jiang W, et al. Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. J Exp Clin Cancer Res. 2014;33:85 pubmed publisher
    We previously identified platelet-activating factor receptor (PAFR) as being overexpressed in ovarian cancer and found that its ligand PAF evoked EGFR phosphorylation using the phospho-antibody microarray...
  25. Wang Q, An Y, Yuan Q, Qi Y, Ou Y, Chen J, et al. Identification of allelic expression imbalance genes in human hepatocellular carcinoma through massively parallel DNA and RNA sequencing. Med Oncol. 2016;33:38 pubmed publisher
    ..Our study provides new insight into AEI events that may contribute to understanding gene expression regulation, cell proliferation and migration, and tumorigenesis. ..
  26. Ocana J, Romer E, Sahu R, Pawelzik S, Fitzgerald G, Kaplan M, et al. Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms. J Immunol. 2018;200:4004-4011 pubmed publisher
    ..Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR)...
  27. Reyes Quiroz M, Alba G, Santa Maria C, Saenz J, Geniz I, Jimenez J, et al. Platelet-activating factor downregulates the expression of liver X receptor-? and its target genes in human neutrophils. FEBS J. 2014;281:970-82 pubmed publisher
  28. Wang Q, Xuan D, Zhong D, Qu Y, Yu J, Cao H, et al. [Role of platelet-activating factor receptor in adhesion and invasion of Aggregatibacter actinomycetemcomitans in human umbilical vein endothelial cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:73-7 pubmed
    To explore the role of platelet-activating factor receptor (PAFR) in adhesion and invasion of phospho- rylcholine (PC)-positive Aggregatibacter actinomycetemcomitans in cultured human umbilical vein endothelial cells (HUVEC)...
  29. Lee J, Simborio H, Reyes A, Hop H, Arayan L, Lee H, et al. Influence of platelet-activating factor receptor (PAFR) on Brucella abortus infection: implications for manipulating the phagocytic strategy of B. abortus. BMC Microbiol. 2016;16:70 pubmed publisher
    ..abortus. Accordingly, we demonstrated that platelet-activating factor receptor (PAFR) affects host cell response against B. abortus infection. First of all, B...
  30. Ma S, Feng C, Dai G, Song Y, Zhou G, Zhang X, et al. In silico target fishing for the potential bioactive components contained in Huanglian Jiedu Tang (HLJDD) and elucidating molecular mechanisms for the treatment of sepsis. Chin J Nat Med. 2015;13:30-40 pubmed publisher
    ..The 3D structures of the PAFR and TXA2R proteins were established using the homology modelling (HM) method, and the molecular effects for sepsis ..
  31. Bhosle V, Rivera J, Zhou T, Omri S, Sanchez M, Hamel D, et al. Nuclear localization of platelet-activating factor receptor controls retinal neovascularization. Cell Discov. 2016;2:16017 pubmed publisher
  32. Shida Sakazume T, Endo Sakamoto Y, Unozawa M, Fukumoto C, Shimada K, Kasamatsu A, et al. Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor. PLoS ONE. 2015;10:e0120143 pubmed publisher
    ..the association between LPCAT1 expression and the platelet-activating factor (PAF) concentration and PAF-receptor (PAFR) expression. LPCAT1 mRNA and protein were up-regulated significantly (p<0...
  33. Al Obaidi M, Desa M. Mechanisms of Blood Brain Barrier Disruption by Different Types of Bacteria, and Bacterial-Host Interactions Facilitate the Bacterial Pathogen Invading the Brain. Cell Mol Neurobiol. 2018;38:1349-1368 pubmed publisher
    ..For example, platelet-activating factor receptor (PAFR) is responsible for brain invasion during the adhesion of pneumococci to brain endothelial cells, which might lead ..
  34. Lee H, Jeon J, Park O, Chun J, Park J, Rhie G. The poly-γ-d-glutamic acid capsule surrogate of the Bacillus anthracis capsule induces nitric oxide production via the platelet activating factor receptor signaling pathway. Mol Immunol. 2015;68:244-52 pubmed publisher
    ..addition, the induced NO production was significantly suppressed by treatment with antagonists of platelet activating factor receptor (PAFR) or PAFR siRNA, and mediated through PAFR/Jak2/STAT-1 signaling pathway...
  35. Shen P, Morissette M, Vanderstocken G, Gao Y, Hassan M, Roos A, et al. Cigarette Smoke Attenuates the Nasal Host Response to Streptococcus pneumoniae and Predisposes to Invasive Pneumococcal Disease in Mice. Infect Immun. 2016;84:1536-1547 pubmed publisher
    ..Mechanistically, deficiency in interleukin 1α (IL-1α) or platelet-activating factor receptor (PAFR), an important host receptor thought to bind and facilitate pneumococcal invasiveness, did not rescue cigarette ..
  36. Zhang Y, Zhang H, Zhou X, Xu Y, Wang Y, Ye Z, et al. [Activation of platelet activating factor receptor by Acinetobacter baumannii results in oxidative stress and apoptosis in human bronchial epithelial cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2018;34:421-426 pubmed
    Objective To investigate the effect of platelet activating factor receptor (PAFR) on human bronchial epithelial (HBE) cells infected by Acinetobacter baumannii (A. baumannii)...
  37. Agrawal V, Jaiswal M, Ilievski V, Beaman K, Jilling T, Hirsch E. Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. Biol Reprod. 2014;91:119 pubmed publisher
    ..We conclude that PAF signaling plays an important role in bacterially induced preterm delivery. Furthermore, in addition to its cognate receptor, PAF signaling in peritoneal macrophages requires TLR4, MyD88, and TRIF. ..
  38. de Oliveira M, Menezes Garcia Z, Arifa R, de Paula T, Andrade J, Santos S, et al. Platelet-activating factor modulates fat storage in the liver induced by a high-refined carbohydrate-containing diet. J Nutr Biochem. 2015;26:978-85 pubmed publisher
    ..Wild-type (WT) and PAF receptor-deficient (PAFR(-/-)) mice were fed the same diets for 8 weeks...
  39. Bellizzi M, Geathers J, Allan K, Gelbard H. Platelet-Activating Factor Receptors Mediate Excitatory Postsynaptic Hippocampal Injury in Experimental Autoimmune Encephalomyelitis. J Neurosci. 2016;36:1336-46 pubmed publisher
    ..damage following a burst of synaptic activity in a manner dependent on platelet-activating factor receptor (PAFR) signaling...
  40. Loh L, Gao G, Tuomanen E. Dissecting Bacterial Cell Wall Entry and Signaling in Eukaryotic Cells: an Actin-Dependent Pathway Parallels Platelet-Activating Factor Receptor-Mediated Endocytosis. MBio. 2017;8: pubmed publisher epithelial and endothelial cells, in addition to the previously described platelet-activating factor receptor (PAFr)-dependent uptake pathway...
  41. Kurano M, Darestani S, Shinnakasu A, Yamamoto K, Dochi Y, Uemura K, et al. mRNA expression of platelet activating factor receptor (PAFR) in peripheral blood mononuclear cells is associated with albuminuria and vascular dysfunction in patients with type 2 diabetes. Diabetes Res Clin Pract. 2018;136:124-133 pubmed publisher
    ..The mRNA expression of platelet activating factor receptor (PAFR) differed most markedly between the three groups and was significantly higher in the ..
  42. Liang H, Pan Z, Zhao X, Liu L, Sun J, Su X, et al. LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d. Theranostics. 2018;8:1180-1194 pubmed publisher
    ..b>Conclusion: Taken together, our study elucidated the role and mechanism of PFL in cardiac fibrosis, indicating the potential role of PFL inhibition as a novel therapy for cardiac fibrosis. ..
  43. Cao C, Tan Q, Xu C, He L, Yang L, Zhou Y, et al. Structural basis for signal recognition and transduction by platelet-activating-factor receptor. Nat Struct Mol Biol. 2018;: pubmed publisher
    Platelet-activating-factor receptor (PAFR) responds to platelet-activating factor (PAF), a phospholipid mediator of cell-to-cell communication that exhibits diverse physiological effects...
  44. Melnikova V, Mourad Zeidan A, Lev D, Bar Eli M. Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis. J Biol Chem. 2006;281:2911-22 pubmed
    ..its ability to activate CREB and ATF-1 in eight cultured human melanoma cell lines, and we found that PAF receptor (PAFR) was expressed in all eight lines...
  45. Yamaguchi M, Matsui M, Higa R, Yamazaki Y, Ikari A, Miyake M, et al. A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation. Biochem Pharmacol. 2015;93:482-95 pubmed publisher
    ..receptor signaling contributed to chronic inflammation in the white adipose tissue (WAT) of PAF receptor-knockout (PAFR-KO) mice...
  46. Wang Y, Gao Z, Zhang Y, Feng S, Liu Y, Shields L, et al. Attenuated Reactive Gliosis and Enhanced Functional Recovery Following Spinal Cord Injury in Null Mutant Mice of Platelet-Activating Factor Receptor. Mol Neurobiol. 2016;53:3448-3461 pubmed publisher
    ..Excessive PAF plays an important role in neural injury via its specific receptor (PAFR)...
  47. Kishimoto S, Shimadzu W, Izumi T, Shimizu T, Fukuda T, Makino S, et al. Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils. J Immunol. 1996;157:4126-32 pubmed
    ..These findings will be of value for understanding the mechanisms of selective infiltration and activation of eosinophils in allergic diseases in which PAF and IL-5 are crucially involved. ..
  48. Richardson R, Marjoram R, Barr A, Snyderman R. RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses. Biochemistry. 2001;40:3583-8 pubmed
    ..signaling (RGS) in chemoattractant-mediated responses, RGS4 and the receptors for platelet-activating factor (PAFR), formylated peptides (FR), or interleukin-8 (CXCR1) were stably coexpressed in a rat basophilic leukemia (RBL-2H3) ..
  49. Le Gouill C, Parent J, Rola Pleszczynski M, Stankova J. Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor. FEBS Lett. 1997;402:203-8 pubmed
    ..All three residues appear essential for the proper folding and surface expression of the PAF receptor protein. ..
  50. Suri R, Periselneris J, Lanone S, Zeidler Erdely P, Melton G, Palmer K, et al. Exposure to welding fumes and lower airway infection with Streptococcus pneumoniae. J Allergy Clin Immunol. 2016;137:527-534.e7 pubmed publisher adhere to and infect lower airway cells is mediated by host-expressed platelet-activating factor receptor (PAFR)...
  51. Filgueiras L, Koga M, Quaresma P, Ishizuka E, Montes M, Prada P, et al. PAFR in adipose tissue macrophages is associated with anti-inflammatory phenotype and metabolic homoeostasis. Clin Sci (Lond). 2016;130:601-12 pubmed publisher
    Metabolic dysfunction is associated with adipose tissue inflammation and macrophage infiltration. PAFR (platelet-activating factor receptor) is expressed in several cell types and binds to PAF (platelet-activating factor) and oxidized ..
  52. Seyfried C, Schweickart V, Godiska R, Gray P. The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1. Genomics. 1992;13:832-4 pubmed
    ..Analysis of somatic cell hybrids suggests that the PAF receptor is encoded by a single gene on human chromosome 1. ..
  53. Messadi A, Fekih Mrissa N, Zaouali J, Layouni S, Nsiri B, Yedeas M, et al. [Implication of platelet-activating factor receptor A224D mutation in susceptibility to relapsing-remitting multiple sclerosis: A Tunisian population study]. Pathol Biol (Paris). 2012;60:185-9 pubmed publisher
    ..Further studies will be necessary to confirm the dominant role of PAFR A224D mutation and to elucidate the effect of this mutation on platelet-activating factor/platelet-activating ..
  54. Giaginis C, Kourou E, Giagini A, Goutas N, Patsouris E, Kouraklis G, et al. Platelet-activating factor (PAF) receptor expression is associated with histopathological stage and grade and patients' survival in gastric adenocarcinoma. Neoplasma. 2014;61:309-17 pubmed
    ..PAF) has been considered as potent inflammatory lipid mediator that exerts its actions by binding to PAF receptor (PAFR)...
  55. Sugimoto T, Tsuchimochi H, McGregor C, Mutoh H, Shimizu T, Kurachi Y. Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. Biochem Biophys Res Commun. 1992;189:617-24 pubmed
    ..These results suggest a tissue-specific translational mechanism responsible for regulation of the expression of the PAF receptor mRNA in these tissues. ..
  56. Ahmed A, Dearn S, Shams M, Li X, Sangha R, Rola Pleszczynski M, et al. Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125. FASEB J. 1998;12:831-43 pubmed
    ..These data support our premise that this autocoid acts as an angiogenic mediator in the regeneration of the endometrium after menses and as a vasodilator to promote blastocyst attachment during the implantation process. ..
  57. Kim Y, Bae J, Kim I, Chang C, Oh S, Kim C. SIRT1 prevents pulmonary thrombus formation induced by arachidonic acid via downregulation of PAF receptor expression in platelets. Platelets. 2016;27:735-742 pubmed
    ..AA- and PAF-mediated platelet aggregations were suppressed by WEB2086, a PAF receptor (PAFR) antagonist...
  58. Patel P, Kearney J. CD36 and Platelet-Activating Factor Receptor Promote House Dust Mite Allergy Development. J Immunol. 2017;199:1184-1195 pubmed publisher
    ..The major PC receptors involved in immune responses include CD36 and platelet-activating factor receptor (PAFR)...
  59. Dantoft W, Martínez Vicente P, Jafali J, Pérez Martínez L, Martin K, Kotzamanis K, et al. Genomic Programming of Human Neonatal Dendritic Cells in Congenital Systemic and In Vitro Cytomegalovirus Infection Reveal Plastic and Robust Immune Pathway Biology Responses. Front Immunol. 2017;8:1146 pubmed publisher
    ..In comparison with adults, a minimal number of subtle quantitative and temporal differences may contribute to variability in host susceptibility and resilience, in a context dependent manner...
  60. Plotkowski M, Estato V, Santos S, da Silva M, Miranda A, de Miranda P, et al. Contribution of the platelet activating factor signaling pathway to cerebral microcirculatory dysfunction during experimental sepsis by ExoU producing Pseudomonas aeruginosa. Pathog Dis. 2015;73: pubmed publisher
    ..These phenomena were mediated by the platelet activating factor receptor (PAFR) pathway because they were reversed in mice treated with a PAFR antagonist prior to infection...
  61. O Toole R, Shukla S, Walters E. Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?. J Transl Med. 2016;14:304 pubmed
    ..We have recently determined that increased expression of PAFr correlates with higher levels of adhesion to human bronchial epithelial cells by non-typable Haemophilus influenzae ..
  62. Miyashita L, Suri R, Dearing E, Mudway I, Dove R, Neill D, et al. E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells. Eur Respir J. 2018;51: pubmed publisher
    ..Since oxidative stress in airway cells increases platelet-activating factor receptor (PAFR) expression, and PAFR is co-opted by pneumococci to adhere to host cells, we hypothesised that E-cigarette vapour ..
  63. Perron A, Chen Z, Gingras D, Dupre D, Stankova J, Rola Pleszczynski M. Agonist-independent desensitization and internalization of the human platelet-activating factor receptor by coumermycin-gyrase B-induced dimerization. J Biol Chem. 2003;278:27956-65 pubmed
    ..Taken together, these findings suggest a novel mechanism of GPCR desensitization and internalization triggered by dimerization. ..
  64. Denizot Y, Donnard M, Guglielmi L, Faucher J, Jaccard A, Bordessoule D, et al. Detection of functional platelet-activating factor receptors on leukemic B cells of chronic lymphocytic leukemic patients. Leuk Lymphoma. 2004;45:515-8 pubmed
    ..In the light of the potent immunoregulatory role of PAF on B cell physiology, it is suggested that the presence or absence of PAF-R on leukemic B cells may profoundly affect their in vivo behavior. ..
  65. Doublier S, Zennaro C, Spatola T, Lupia E, Bottelli A, Deregibus M, et al. HIV-1 Tat reduces nephrin in human podocytes: a potential mechanism for enhanced glomerular permeability in HIV-associated nephropathy. AIDS. 2007;21:423-32 pubmed
    ..The present results define a mechanism by which Tat may reduce nephrin expression in podocytes, thus increasing glomerular permeability. This provides new insights in the understanding of HIVAN pathogenesis. ..
  66. Hanouni M, Bernal G, McBride S, Narvaez V, Ibe B. Hypoxia and hyperoxia potentiate PAF receptor-mediated effects in newborn ovine pulmonary arterial smooth muscle cells: significance in oxygen therapy of PPHN. Physiol Rep. 2016;4: pubmed publisher
    Platelet-activating factor (PAF) acting via its receptor (PAFR) is implicated in the pathogenesis of persistent pulmonary hypertension of the newborn (PPHN)...
  67. Lv X, Liu S, Li K, Cui B, Liu C, Hu Z. Cigarette smoke promotes COPD by activating platelet-activating factor receptor and inducing neutrophil autophagic death in mice. Oncotarget. 2017;8:74720-74735 pubmed publisher
    ..Here we report that CS induction of autophagy in neutrophils by activating platelet- activating factor receptor (PAFR) promotes COPD progression in mouse...
  68. Wang E, Han Y, Jia X. PAFR-deficiency alleviates myocardial ischemia/reperfusion injury in mice via suppressing inflammation, oxidative stress and apoptosis. Biochem Biophys Res Commun. 2018;495:2475-2481 pubmed publisher
    ..PAF acts on a single receptor (PAFR), which is expressed on cellular and nuclear membranes of various cell types...
  69. Fiedler E, Bhutkar A, Lawler E, Besada R, Hemann M. In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1+ BCP-ALL. Blood Adv. 2018;2:1229-1242 pubmed publisher
    ..PAF-induced cell death as well as surface levels of PAF receptor (PAFR) in our model are altered upon dasatinib treatment and depend on the local leukemia microenvironment; the response ..
  70. Rios F, Ferracini M, Pecenin M, Koga M, Wang Y, Ketelhuth D, et al. Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts. PLoS ONE. 2013;8:e76893 pubmed publisher
    ..In a previous study, we showed that CD36 and the receptor for platelet-activating factor (PAFR) are required for oxLDL to activate gene transcription for cytokines and CD36...
  71. Toscano E, Silva B, Victoria E, Cardoso A, Miranda A, Sugimoto M, et al. Platelet-activating factor receptor (PAFR) plays a crucial role in experimental global cerebral ischemia and reperfusion. Brain Res Bull. 2016;124:55-61 pubmed publisher
    ..PAF receptor (PAFR) may be expressed on cellular and nuclear membranes of various cell types, especially leukocytes, platelets, ..
  72. Valone F. Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine. Immunology. 1984;52:169-74 pubmed
    ..The capacity of this protein to bind AGEPC suggests that it represents a constituent of the human platelet receptor for AGEPC. ..
  73. Nakamura M, Honda Z, Matsumoto T, Noma M, Shimizu T. Isolation and properties of platelet-activating factor receptor cDNAs. J Lipid Mediat. 1993;6:163-8 pubmed
  74. Lukashova V, Chen Z, DUHE R, Rola Pleszczynski M, Stankova J. Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus. J Immunol. 2003;171:3794-800 pubmed
    ..The PAF receptor (PAFR) belongs to the G protein-coupled, heptahelical receptor superfamily...
  75. Beaudeux J, Said T, Ninio E, Ganné F, Soria J, Delattre J, et al. Activation of PAF receptor by oxidised LDL in human monocytes stimulates chemokine releases but not urokinase-type plasminogen activator expression. Clin Chim Acta. 2004;344:163-71 pubmed
    ..Our results indicated that PAF-like oxidation products are responsible for the monocyte chemokine releases, but did not contribute to the enhanced monocyte uPA expression by oxidised LDL. ..
  76. Stengel D, O Neil C, Brocheriou I, Karabina S, Durand H, Caplice N, et al. PAF-receptor is preferentially expressed in a distinct synthetic phenotype of smooth muscle cells cloned from human internal thoracic artery: functional implications in cell migration. Biochem Biophys Res Commun. 2006;346:693-9 pubmed
    ..The presence of functional PAF-R in arterial spindle-shaped SMCs of synthetic phenotype may be important for their migration from the media into the intima and atherosclerotic plaques formation...
  77. Onuchic A, Machado C, Saito R, Rios F, Jancar S, Chammas R. Expression of PAFR as part of a prosurvival response to chemotherapy: a novel target for combination therapy in melanoma. Mediators Inflamm. 2012;2012:175408 pubmed publisher
    Melanoma cells express the platelet-activating factor receptor (PAFR) and, thus, respond to PAF, a bioactive lipid produced by both tumour cells and those in the tumour microenvironment such as macrophages...
  78. Aratake Y, Okuno T, Matsunobu T, Saeki K, Takayanagi R, Furuya S, et al. Helix 8 of leukotriene B4 receptor 1 inhibits ligand-induced internalization. FASEB J. 2012;26:4068-78 pubmed publisher
    ..BLT1 LLAA showed enhanced basal and ligand-dependent phosphorylation compared to WT BLT1. Taken together, helix 8 of BLT1 inhibits receptor internalization by suppressing the excessive phosphorylation of the C-terminal tail. ..
  79. Haslam R, Williams K, Davidson M. Receptor-effector coupling in platelets: roles of guanine nucleotides. Adv Exp Med Biol. 1985;192:265-80 pubmed
    ..In intact human platelets, PAF receptors may interact preferentially with a guanine nucleotide-binding protein that promotes phosphoinositide breakdown by phospholipase C, rather than with Gi. ..
  80. Chase P, Halonen M, Regan J. Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region. Am J Respir Cell Mol Biol. 1993;8:240-4 pubmed
    ..These data indicate that a gene for a human PAF receptor is present in the genome without introns in the coding sequence and that splicing of mRNA encoding PAF receptors appears to occur in the 5'-untranslated region. ..
  81. Schoneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, et al. A novel subgroup of class I G-protein-coupled receptors. Biochim Biophys Acta. 1999;1446:57-70 pubmed
    ..Since none of the applied substances led to significant changes in second messenger levels (cAMP and inositol phosphates), the natural ligand and coupling profile of this novel GPCR subgroup remains unknown. ..
  82. Barletta E, Mugnai G, Ruggieri S. Platelet activating factor inhibits the expression of matrix metalloproteinases and affects invasiveness and differentiation in a system of human neuroblastoma clones. Biol Chem. 2002;383:189-97 pubmed
  83. McLaughlin N, Banerjee A, Kelher M, Gamboni Robertson F, Hamiel C, Sheppard F, et al. Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. J Immunol. 2006;176:7039-50 pubmed
    ..We hypothesize that platelet-activating factor (PAF) receptor (PAFR) ligation requires CME and causes engagement of beta-arrestin-1 and recruitment of a p38 MAPK signalosome that ..
  84. Travers J, Edenberg H, Zhang Q, Al Hassani M, Yi Q, Baskaran S, et al. Augmentation of UVB radiation-mediated early gene expression by the epidermal platelet-activating factor receptor. J Invest Dermatol. 2008;128:455-60 pubmed
    ..These studies provide evidence that the epidermal PAF-R can modulate UVB-mediated early gene expression. ..
  85. Kaneko K, Travers J, Matsui M, Young A, Norval M, Walker S. cis-Urocanic acid stimulates primary human keratinocytes independently of serotonin or platelet-activating factor receptors. J Invest Dermatol. 2009;129:2567-73 pubmed publisher
    ..Thus, cis-UCA stimulates mediator production by a pathway that is independent of these receptors in human keratinocytes, and these cells may not be the major target for cis-UCA-induced immune suppression...
  86. Balestrieri M, Giovane A, Milone L, Servillo L. Endothelial progenitor cells express PAF receptor and respond to PAF via Ca(2+)-dependent signaling. Biochim Biophys Acta. 2010;1801:1123-32 pubmed publisher
    ..These novel findings, revealing that early EPC respond to PAF signaling, unveil an inflammatory pathway that may play a crucial role in the outcome of cardiovascular cell therapy with EPC. ..
  87. Bachi A, Dos Santos L, Nonogaki S, Jancar S, Jasiulionis M. Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor. Mediators Inflamm. 2012;2012:610371 pubmed publisher
    There is evidence that the platelet-activating factor receptor (PAFR) is involved in the clearance of apoptotic cells by macrophages, and that this is associated with anti-inflammatory phenotype...
  88. Hosoki K, Nakamura A, Nagao M, Hiraguchi Y, Tanida H, Tokuda R, et al. Staphylococcus aureus directly activates eosinophils via platelet-activating factor receptor. J Leukoc Biol. 2012;92:333-41 pubmed publisher
    ..b>PAFR appears to be involved in phagocytosis of Gram-positive bacteria by leukocytes...
  89. Rios F, Koga M, Pecenin M, Ferracini M, Gidlund M, Jancar S. Oxidized LDL induces alternative macrophage phenotype through activation of CD36 and PAFR. Mediators Inflamm. 2013;2013:198193 pubmed publisher macrophage scavenger receptors, including CD36; we have recently found that Platelet-Activating Factor Receptor (PAFR) is also involved...
  90. Yu Y, Zhang M, Zhang X, Cai Q, Hong S, Jiang W, et al. Synergistic effects of combined platelet-activating factor receptor and epidermal growth factor receptor targeting in ovarian cancer cells. J Hematol Oncol. 2014;7:39 pubmed publisher
    ..We previously identified platelet-activating factor receptor (PAFR) as being overexpressed in ovarian cancer and found that its ligand PAF evoked EGFR phosphorylation...
  91. Zhang C, Sun Q. Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer. J Huazhong Univ Sci Technolog Med Sci. 2017;37:319-325 pubmed publisher
    ..Additionally, the blue module was the exclusive gene clusters related to OS. Platelet activating factor receptor (PTAFR) and feline Gardner-Rasheed (FGR) were the top hub genes in both modeling datasets and the ..
  92. Bito H, Honda Z, Nakamura M, Shimizu T. Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA. Eur J Biochem. 1994;221:211-8 pubmed
    ..Isolation of rat PAF-receptor cDNA should facilitate further analysis of PAF-receptor function and pharmacology in diverse pathophysiological processes. ..