PLAT

Summary

Gene Symbol: PLAT
Description: plasminogen activator, tissue type
Alias: T-PA, TPA, tissue-type plasminogen activator, alteplase, plasminogen/activator kringle, reteplase, t-plasminogen activator
Species: human
Products:     PLAT

Top Publications

  1. Ladenvall P, Johansson L, Jansson J, Jern S, Nilsson T, Tjärnlund A, et al. Tissue-type plasminogen activator -7,351C/T enhancer polymorphism is associated with a first myocardial infarction. Thromb Haemost. 2002;87:105-9 pubmed
    We recently identified a polymorphic Sp1 binding site in an enhancer at the tissue-type plasminogen activator (tPA) locus (tPA -7,351C/T), which was associated with vascular tPA release...
  2. Teesalu T, Kulla A, Simisker A, Sirén V, Lawrence D, Asser T, et al. Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system. Thromb Haemost. 2004;92:358-68 pubmed
    Tissue plasminogen activator (tPA) is increasingly recognized to play important roles in various physiological and pathological processes in the central nervous system (CNS)...
  3. Medina M, Ledesma M, Domínguez J, Medina M, Zafra D, Alameda F, et al. Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation. EMBO J. 2005;24:1706-16 pubmed
    Tissue plasminogen activator (tPA) is the main activator of plasminogen into plasmin in the brain where it may have beneficial roles but also neurotoxic effects that could be plasmin dependent or not...
  4. Jood K, Ladenvall P, Tjarnlund Wolf A, Ladenvall C, Andersson M, Nilsson S, et al. Fibrinolytic gene polymorphism and ischemic stroke. Stroke. 2005;36:2077-81 pubmed
    The tissue-type plasminogen activator (tPA) -7351C>T and the plasminogen activator inhibitor type 1 (PAI-1) -675 4G>5G polymorphisms influence transcriptional activity...
  5. Gürkan A, Emingil G, Saygan B, Cinarcik S, Atilla G, Kose T, et al. Tissue plasminogen activator and plasminogen activator inhibitor-1 gene polymorphisms in patients with chronic periodontitis. J Periodontol. 2007;78:1256-63 pubmed
    ..046; P = 0.025). t-PA or PAI-1 genotypes are not associated with susceptibility to CP in Turkish subjects. Conversely, the 4G allele of the PAI-1 gene could be related to a decreased susceptibility to CP in non-smokers. ..
  6. Attia J, Thakkinstian A, Wang Y, Lincz L, Parsons M, Sturm J, et al. The PAI-1 4G/5G gene polymorphism and ischemic stroke: an association study and meta-analysis. J Stroke Cerebrovasc Dis. 2007;16:173-9 pubmed
    ..The results also sound a cautionary note that varying LD structure across populations may obscure the relationship with a causative locus, and that future meta-analyses need to look beyond a simple pooled estimate. ..
  7. Lovrecic L, Ristic S, Starcevic Cizmarevic N, Brajenović Milić B, Jazbec S, Sepcic J, et al. PAI and TPA gene polymorphisms in multiple sclerosis. Mult Scler. 2008;14:243-7 pubmed
    ..Alu insertion/deletion (I/D) genetic polymorphism in TPA gene in MS patients has not been analysed previously...
  8. Schoenhard J, Asselbergs F, Poku K, Stocki S, Gordon S, Vaughan D, et al. Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population. Hum Genet. 2008;124:479-88 pubmed publisher
    ..significant relationship was found between the PAI-1 4G/5G (rs1799768) polymorphism on PAI-1 levels in females, the TPA I/D (rs4646972) polymorphism on t-PA and PAI-1 in males, the renin (rs3730103) polymorphism on t-PA and PAI-1 in ..
  9. Correa F, Gauberti M, Parcq J, Macrez R, Hommet Y, Obiang P, et al. Tissue plasminogen activator prevents white matter damage following stroke. J Exp Med. 2011;208:1229-42 pubmed publisher
    Tissue plasminogen activator (tPA) is the only available treatment for acute stroke. In addition to its vascular fibrinolytic action, tPA exerts various effects within the brain, ranging from synaptic plasticity to control of cell fate...

More Information

Publications114 found, 100 shown here

  1. Suzuki Y, Yasui H, Brzoska T, Mogami H, Urano T. Surface-retained tPA is essential for effective fibrinolysis on vascular endothelial cells. Blood. 2011;118:3182-5 pubmed publisher
    In a previous study, we demonstrated unique secretory dynamics of tissue plasminogen activator (tPA) in which tPA was retained on the cell surface in a heavy chain-dependent manner after exocytosis from secretory granules in vascular ..
  2. Kim P, Tieu L, Stafford A, Fredenburgh J, Weitz J. A high affinity interaction of plasminogen with fibrin is not essential for efficient activation by tissue-type plasminogen activator. J Biol Chem. 2012;287:4652-61 pubmed publisher
    Fibrin (Fn) enhances plasminogen (Pg) activation by tissue-type plasminogen activator (tPA) by serving as a template onto which Pg and tPA assemble...
  3. Siao C, Tsirka S. Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II. J Neurosci. 2002;22:3352-8 pubmed
    ..One molecule whose expression is upregulated after excitotoxic injury is tissue plasminogen activator (tPA), a serine protease with dual roles in the CNS...
  4. Jannes J, Hamilton Bruce M, Pilotto L, Smith B, Mullighan C, Bardy P, et al. Tissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke. Stroke. 2004;35:1090-4 pubmed
    ..Endogenous tissue plasminogen activator (TPA) is the primary mediator of intravascular fibrinolysis and is predominantly expressed by the endothelium of small ..
  5. Wolf A, Medcalf R, Jern C. The t-PA -7351C>T enhancer polymorphism decreases Sp1 and Sp3 protein binding affinity and transcriptional responsiveness to retinoic acid. Blood. 2005;105:1060-7 pubmed
    ..The reduced binding affinity of Sp1/Sp3 to the T allele could explain our earlier observations of a reduced t-PA release and an increased risk of myocardial infarction in individuals carrying this allele. ..
  6. Asselbergs F, Williams S, Hebert P, Coffey C, Hillege H, Navis G, et al. Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels. Genomics. 2007;89:362-9 pubmed
    ..These results support the idea that the interplay between the renin-angiotensin, bradykinin, and fibrinolytic systems might play an important role in t-PA and PAI-1 biology. ..
  7. Suzuki Y, Mogami H, Ihara H, Urano T. Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells. Blood. 2009;113:470-8 pubmed publisher
    We analyzed the secretory dynamics of tissue plasminogen activator (tPA) in EA.hy926 cells, an established vascular endothelial cell (VEC) line producing GFP-tagged tPA, using total internal reflection-fluorescence (TIR-F) microscopy...
  8. Sahli D, Eriksson J, Boman K, Svensson M. Tissue plasminogen activator (tPA) activity is a novel and early marker of asymptomatic LEAD in type 2 diabetes. Thromb Res. 2009;123:701-6 pubmed publisher
    ..early asymptomatic lower extremity arterial disease and blood levels of HbA1c, lipids and fibrinolysis markers (tPA-activity, tPA mass, PAI-1 activity, tPA-PAI-1 complex) was assessed...
  9. Maguire J, Thakkinstian A, Levi C, Lincz L, Bisset L, Sturm J, et al. Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 polymorphisms on 90-day ischemic stroke functional outcome: a novel finding. J Stroke Cerebrovasc Dis. 2011;20:134-44 pubmed publisher
    ..glycoprotein Ib? (GPIb?) rs224309 and rs6065, glycoprotein IIIa (GPIIIa) rs5918, tissue plasminogen activator (tPA) rs63020761, plasminogen activating inhibitor (PAI-1) rs72578597, and cyclooxygenase-2 (COX-2) rs5275 and rs20417...
  10. Ahmed W, Malik M, Saeed I, Khan A, Sadeque A, Kaleem U, et al. Role of tissue plasminogen activator and plasminogen activator inhibitor polymorphism in myocardial infarction. Mol Biol Rep. 2011;38:2541-8 pubmed publisher
    ..72, OR=3.7 (95% CI=1.71-8.18)) and lower HDL levels (P<0.05) were found to be significantly associated with the disease. In conclusion the PAI-1 gene polymorphism was found to have a gender specific role in the female MI patients. ..
  11. Babu M, Prabha T, Kaul S, Al Hazzani A, Shafi G, Roy S, et al. Association of genetic variants of fibrinolytic system with stroke and stroke subtypes. Gene. 2012;495:76-80 pubmed publisher
    Genetic variants of tPA (PLAT) and PAI-1 genes have been suggested to be the risk factors for stroke...
  12. Mantuano E, Lam M, Gonias S. LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein. J Biol Chem. 2013;288:34009-18 pubmed publisher
    In addition to functioning as an activator of fibrinolysis, tissue-type plasminogen activator (tPA) interacts with neurons and regulates multiple aspects of neuronal cell physiology...
  13. Pereira B, Brazón J. Aqueous extract from Brownea grandiceps flowers with effect on coagulation and fibrinolytic system. J Ethnopharmacol. 2015;160:6-13 pubmed publisher
  14. Tian L, Li H, Li Y, Liu K, Sun Y, Cong Z, et al. A Combination of Chitosan, Cellulose, and Seaweed Polysaccharide Inhibits Postoperative Intra-abdominal Adhesion in Rats. J Pharmacol Exp Ther. 2018;364:399-408 pubmed publisher
    ..effectively suppressed by CCS in vivo, and as a result, the activation of tissue plasminogen activator (tPA, may generate plasmin that is a fibrinolytic factor capable of breaking down fibrin) was significantly promoted, ..
  15. Svenningsen P, Hinrichs G, Zachar R, Ydegaard R, Jensen B. Physiology and pathophysiology of the plasminogen system in the kidney. Pflugers Arch. 2017;469:1415-1423 pubmed publisher
    ..consists of the circulating zymogen plasminogen (Plg) and the tissue- and urokinase-type plasminogen activators, tPA and uPA, expressed in the glomeruli, endothelium and tubular epithelium, respectively, and the inhibitors α<..
  16. Albert V, Arulselvi S, Agrawal D, Pati H, Pandey R. Early posttraumatic changes in coagulation and fibrinolysis systems in isolated severe traumatic brain injury patients and its influence on immediate outcome. Hematol Oncol Stem Cell Ther. 2018;: pubmed publisher
    ..protein S (PS), thrombin/antithrombin complex (TAT), soluble fibrin monomer (sFM), tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) was done...
  17. Wu X, Darlington D, Cap A. Procoagulant and fibrinolytic activity after polytrauma in rat. Am J Physiol Regul Integr Comp Physiol. 2016;310:R323-9 pubmed publisher
    ..Tissue plasminogen activator (tPA) was elevated at 30 min, then decreased below baseline levels after 1 h...
  18. Zhang S, Wotzkow C, Bongoni A, Shaw Boden J, Siegrist M, Taddeo A, et al. Role of the plasma cascade systems in ischemia/reperfusion injury of bone. Bone. 2017;97:278-286 pubmed publisher
    ..of complement fragment C3b/c and fibrin as well as expression of tissue factor (TF), tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), and E-selectin was detected by immunohistochemistry...
  19. Diaz A, Merino P, Manrique L, Ospina J, Cheng L, Wu F, et al. A Cross Talk between Neuronal Urokinase-type Plasminogen Activator (uPA) and Astrocytic uPA Receptor (uPAR) Promotes Astrocytic Activation and Synaptic Recovery in the Ischemic Brain. J Neurosci. 2017;37:10310-10322 pubmed publisher
    ..or with a four-amino acid substitution into the growth factor domain of uPA that abrogates its binding to uPAR (PlatGFDhu/GFDhu) to investigate the mechanism whereby uPA promotes neurorepair in the ischemic brain...
  20. Al Horani R. Serpin regulation of fibrinolytic system: implications for therapeutic applications in cardiovascular diseases. Cardiovasc Hematol Agents Med Chem. 2014;12:91-125 pubmed
    ..of a cascade of enzymatic reactions in which serine proteases such as plasmin, tissue plasminogen activator (tPA), and urokinase plasminogen activator (uPA) are the key players...
  21. Raij L, Tian R, Wong J, He J, Campbell K. Podocyte injury: the role of proteinuria, urinary plasminogen, and oxidative stress. Am J Physiol Renal Physiol. 2016;311:F1308-F1317 pubmed publisher
    ..We show that human podocytes express uPA and three Plg receptors: uPAR, tPA, and Plg-RKT...
  22. Hoirisch Clapauch S, Nardi A. Markers of low activity of tissue plasminogen activator/plasmin are prevalent in schizophrenia patients. Schizophr Res. 2014;159:118-23 pubmed publisher
    Clot buster tissue plasminogen activator (tPA) and its end-product plasmin play a well-defined role in neurochemistry...
  23. Senapati S, Wang F, Ord T, Coutifaris C, Feng R, Mainigi M. Superovulation alters the expression of endometrial genes critical to tissue remodeling and placentation. J Assist Reprod Genet. 2018;35:1799-1808 pubmed publisher
    ..of the differentially expressed genes showed enrichment for genes involved in endometrial remodeling including PLAT, HSPE2, MMP2, and TIMP1...
  24. Montesinos M, Desai Merchant A, Cronstein B. Promotion of Wound Healing by an Agonist of Adenosine A2A Receptor Is Dependent on Tissue Plasminogen Activator. Inflammation. 2015;38:2036-41 pubmed publisher
    ..wound closure in wild-type, urokinase plasminogen activator (uPA)-deficient, and tissue plasminogen activator (tPA)-deficient mice...
  25. Seth D, Hogg P, Gorrell M, McCaughan G, Haber P. Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease. J Hepatol. 2008;48:614-27 pubmed publisher
    ..We have recently identified increased expression of a number of genes (annexin A2 (ANXA2), p11, tPA and PAI-1) that implicate fibrinolysis in ALD progression...
  26. Walker C, West A, Browning L, Madden J, Gambell J, Jebb S, et al. The Pattern of Fatty Acids Displaced by EPA and DHA Following 12 Months Supplementation Varies between Blood Cell and Plasma Fractions. Nutrients. 2015;7:6281-93 pubmed publisher
    ..ester (CE) and triglyceride (TAG) and for blood mononuclear cells (MNC), red blood cells (RBC) and platelets (PLAT)...
  27. Mantuano E, Lam M, Shibayama M, Campana W, Gonias S. The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. J Cell Sci. 2015;128:3478-88 pubmed publisher
    ..Injection of the LRP1 ligands tissue-type plasminogen activator (tPA, also known as PLAT) or MMP9-PEX into crush-injured sciatic nerves activated ERK1/2 in Schwann cells in vivo, and the response was ..
  28. Lee K, Istl A, Dubois L, DeRose G, Forbes T, Wiseman D, et al. Fibrinogen Level and Bleeding Risk During Catheter-Directed Thrombolysis Using Tissue Plasminogen Activator. Vasc Endovascular Surg. 2015;49:175-9 pubmed publisher
    ..004). The low fibrinogen group received a larger dose of tissue plasminogen activator (tPA; P = .009) and had a longer duration of thrombolysis (P = .010)...
  29. Gilmer A, Sweeney L, Nakajima S. Pharmacists' role in a hospital's initiative to become a certified primary stroke center. Am J Health Syst Pharm. 2016;73:S1-7 pubmed publisher
  30. Jin C, Lu L, Zhu Z, Zhang R, Zhang Q, Du R, et al. Increased serum vWF and sVCAM-1 levels are associated with late or very late angiographic stent thrombosis after sirolimus-eluting stent implantation. Coron Artery Dis. 2010;21:273-7 pubmed publisher
    ..Increased serum vWF and sVCAM-1 levels are associated with late ST, suggesting that endothelial dysfunction contributes to the development of late or very late ST. ..
  31. Kong L, Wang Y, Wang X, Wang X, Zhao Y, Wang L, et al. Retinoic acid ameliorates blood-brain barrier disruption following ischemic stroke in rats. Pharmacol Res. 2015;99:125-36 pubmed publisher
    ..Significantly, RA administration immediately after MCAO reduced tissue plasminogen activator (tPA)-induced intracerebral hemorrhage (ICH) and ameliorated neurological deficits 24h after ischemic stroke...
  32. Lemarchand E, Maubert E, Haelewyn B, Ali C, Rubio M, Vivien D. Stressed neurons protect themselves by a tissue-type plasminogen activator-mediated EGFR-dependent mechanism. Cell Death Differ. 2016;23:123-31 pubmed publisher
    In the central nervous system, tissue-type plasminogen activator (tPA) has been associated with both pro-death and prosurvival actions on neurons. In most cases, this has been related to exogenous tPA...
  33. Hoesl M, Oehm S, Durkin P, Darmon E, Peil L, Aerni H, et al. Chemical Evolution of a Bacterial Proteome. Angew Chem Int Ed Engl. 2015;54:10030-4 pubmed publisher
    ..cultures capable of growing on the synthetic noncanonical amino acid L-β-(thieno[3,2-b]pyrrolyl)alanine ([3,2]Tpa) as a sole surrogate for the canonical amino acid L-tryptophan (Trp)...
  34. Yu L, Li G, Li M, Xu F, Beta T, Bao J. Genotypic variation in phenolic acids, vitamin E and fatty acids in whole grain rice. Food Chem. 2016;197:776-82 pubmed publisher
    ..6 to 271.1 ?g/g and comprising approximately 40-57% of total phenolic acid (TPA). The predominant tocopherols (T) and tocotrienols (T3) were ?-T (6.43-12.67 ?g/g) and ?-T3 (12.88-32.75 ?g/g)...
  35. Gong L, Proulle V, Fang C, Hong Z, Lin Z, Liu M, et al. A specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase. J Cell Mol Med. 2016;20:1851-60 pubmed publisher
    ..Plasminogen activator inhibitor-1 (PAI-1) inhibits urokinase-type and tissue-type plasminogen activator (uPA and tPA) and is the major negative regulator of fibrinolysis...
  36. Shang J, Yamashita T, Kono S, Morihara R, Nakano Y, Fukui Y, et al. Effects of Pretreatment with Warfarin or Rivaroxaban on Neurovascular Unit Dissociation after Tissue Plasminogen Activator Thrombolysis in Ischemic Rat Brain. J Stroke Cerebrovasc Dis. 2016;25:1997-2003 pubmed publisher
    ..the risks and benefits of pre-treatment with warfarin or rivaroxaban after tissue-type plasminogen activator (tPA) thrombolysis in ischemic rat brain. Pre-treatment with warfarin (...
  37. Patel A, Parikh R, Huang Y, Liou M, Ratcliffe J, Bertrand O, et al. Pseudoaneurysm after transpedal arterial access for evaluation and treatment of peripheral arterial disease. Cardiovasc Revasc Med. 2017;18:123-127 pubmed publisher
    There has been an increasing use of transpedal arterial access (TPA) for evaluation and treatment of peripheral arterial disease (PAD) over a transfemoral approach (TFA)...
  38. Qiu W, Lei M, Zhou L, Bai X, Lai X, Yu Y, et al. Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration. Histochem Cell Biol. 2017;147:749-758 pubmed publisher
    ..12-o-tetradecanoylphorbol-13-acetate (TPA), a tumor promoter, accelerates reentry of hair follicles into anagen phase...
  39. Menjot de Champfleur N, Saver J, Goyal M, Jahan R, Diener H, Bonafe A, et al. Efficacy of Stent-Retriever Thrombectomy in Magnetic Resonance Imaging Versus Computed Tomographic Perfusion-Selected Patients in SWIFT PRIME Trial (Solitaire FR With the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic. Stroke. 2017;48:1560-1566 pubmed publisher
    ..Patients with middle cerebral artery and distal carotid occlusions were randomized to treatment with tPA (tissue-type plasminogen activator) alone or tPA+stentriever thrombectomy...
  40. Gautheron V, Xie Y, Tisserand M, Raoult H, Soize S, Naggara O, et al. Outcome After Reperfusion Therapies in Patients With Large Baseline Diffusion-Weighted Imaging Stroke Lesions: A THRACE Trial (Mechanical Thrombectomy After Intravenous Alteplase Versus Alteplase Alone After Stroke) Subgroup Analysis. Stroke. 2018;49:750-753 pubmed publisher
    ..with DWIvolume >70 mL, included in the THRACE trial (Mechanical Thrombectomy After Intravenous Alteplase Versus Alteplase Alone After Stroke), we report the associations between baseline parameters and outcome...
  41. Cook R, Rondina M, Horton D. Rivaroxaban for the Long-term Treatment of Spontaneous Ovarian Vein Thrombosis Caused by Factor V Leiden Homozygosity. Ann Pharmacother. 2014;48:1055-1060 pubmed
    ..After initial catheter-directed thrombolysis with tPA, angioplasty of the left renal vein, and heparinoid treatment, rivaroxaban was begun for long-term anticoagulation...
  42. Yamanaka H, Kobayashi K, Okubo M, Noguchi K. Annexin A2 in primary afferents contributes to neuropathic pain associated with tissue type plasminogen activator. Neuroscience. 2016;314:189-99 pubmed publisher
    ..ANX2 has been described as a crucial receptor for thrombolysis by the tissue-type plasminogen activator (tPA) and plasmin system...
  43. Wang B, Liu H, Cai C, Thabit M, Wang P, Li G, et al. Effect of dry mycelium of Penicillium chrysogenum fertilizer on soil microbial community composition, enzyme activities and snap bean growth. Environ Sci Pollut Res Int. 2016;23:20728-20738 pubmed
    ..The lowest GI values (<0.3) were recorded at DMF8 (36 kg DMF/plat) on the first days after applying the fertilizer, indicating that severe phytotoxicity appeared in the DMF8-..
  44. Zhang C, Su Z, Wang L, Shu L, Yang Y, Guo Y, et al. Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1. Biochem Pharmacol. 2016;117:35-45 pubmed publisher
    ..the effect of the BET inhibitor JQ-1 on malignant transformation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin epidermal JB6 P+ cells...
  45. Lee T, Tsang V, Loef E, Birch N. Physiological and pathological functions of neuroserpin: Regulation of cellular responses through multiple mechanisms. Semin Cell Dev Biol. 2017;62:152-159 pubmed publisher
    ..Many are linked to inhibition of neuroserpin's principal enzyme target, tissue plasminogen activator (tPA), although some have been suggested to involve alternate non-inhibitory mechanisms...
  46. Fukuta T, Asai T, Yanagida Y, Namba M, Koide H, Shimizu K, et al. Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke. FASEB J. 2017;31:1879-1890 pubmed publisher
    ..extension of the therapeutic time window (TTW) of thrombolytic therapy with tissue plasminogen activator (tPA) and amelioration of secondary ischemia/reperfusion (I/R) injury are most desirable...
  47. Montt Guevara M, Palla G, Spina S, Bernacchi G, Cecchi E, Campelo A, et al. Regulatory effects of estetrol on the endothelial plasminogen pathway and endothelial cell migration. Maturitas. 2017;99:1-9 pubmed publisher
    ..These results support the hypothesis that E4 acts as an endogenous selective estrogen receptor modulator (SERM), controlling the fibrinolytic system and endothelial cell migration. ..
  48. Winnicki W, Herkner H, Lorenz M, Handisurya A, Kikic Z, Bielesz B, et al. Taurolidine-based catheter lock regimen significantly reduces overall costs, infection, and dysfunction rates of tunneled hemodialysis catheters. Kidney Int. 2018;93:753-760 pubmed publisher
    ..7 vs. 44.3/1000 catheter days) and alteplase rescue significantly more frequent in the citrate group (9.8 vs. 3.8/1000 catheter days)...
  49. Saigo M, Abe S, Ogawa M, Yamashita T, Biro S, Minagoe S, et al. Imbalance of plasminogen activator inhibitor-I/ tissue plasminogen activator and tissue factor/tissue factor pathway inhibitor in young Japanese men with myocardial infarction. Thromb Haemost. 2001;86:1197-203 pubmed
    ..free form tissue factor pathway inhibitor (TFPI), plasminogen, alpha2-antiplasmin, tissue plasminogen activator (tPA), plasminogen activator inhibitor-I (PAI-I), and lipoprotein (a) in 140 young men with MI before age 45 and 150 age-..
  50. Hall J, Pehrson N, Ekestubbe A, Jemt T, Friberg B. A controlled, cross-sectional exploratory study on markers for the plasminogen system and inflammation in crevicular fluid samples from healthy, mucositis and peri-implantitis sites. Eur J Oral Implantol. 2015;8:153-66 pubmed
    ..remodelling were investigated: interleukin-1 beta (IL-1β), interleukin 8 (IL-8), tissue plasminogen activator (tPA), plasminogen activator inhibitor 2 (PAI-2), tartrate-resistant acid phosphatase (TRAP) and cathepsin K (CatK)...
  51. Thammapat P, Meeso N, Siriamornpun S. Effects of the traditional method and an alternative parboiling process on the fatty acids, vitamin E, ?-oryzanol and phenolic acids of glutinous rice. Food Chem. 2016;194:230-6 pubmed publisher
    ..fatty acids (SFA), mono-unsaturated fatty acids (MUFA), ?-oryzanol, ?-tocotrienol and total phenolic acids (TPA) in glutinous rice, while ?-tocopherol, ?-tocopherol and polyunsaturated fatty acids (PUFA) decreased (p<0.05)...
  52. Etman A, Kamphuis C, Pierik F, Burdorf A, van Lenthe F. Residential area characteristics and disabilities among Dutch community-dwelling older adults. Int J Health Geogr. 2016;15:42 pubmed
    ..characteristics and disabilities and whether this association is mediated by transport-related physical activity (TPA)...
  53. Charest Morin R, Street J, Zhang H, Roughead T, Ailon T, Boyd M, et al. Frailty and sarcopenia do not predict adverse events in an elderly population undergoing non-complex primary elective surgery for degenerative conditions of the lumbar spine. Spine J. 2018;18:245-254 pubmed publisher
    ..Total psoas area (TPA) at mid-L3 level on preoperative computed tomography scan adjusted for height (NTPA) defined sarcopenia...
  54. Hu K, Wu C, Mars W, Liu Y. Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling. J Clin Invest. 2007;117:3821-32 pubmed
    ..Here we describe a signaling pathway that leads to this activation. Tissue-type plasminogen activator (tPA) promoted TGF-beta1-mediated alpha-SMA and type I collagen expression in rat kidney interstitial fibroblasts...
  55. Hultman K, Tjarnlund Wolf A, Fish R, Wilhelmsson U, Rydenhag B, Pekny M, et al. Retinoids and activation of PKC induce tissue-type plasminogen activator expression and storage in human astrocytes. J Thromb Haemost. 2008;6:1796-803 pubmed publisher
    ..Moreover, a regulated release of t-PA can be induced from these cells. This raises the possibility that astrocytes contribute to the regulation of extracellular t-PA levels in the CNS. ..
  56. Cakir M, Cekic O, Yilmaz O. Pneumatic displacement of acute submacular hemorrhage with and without the use of tissue plasminogen activator. Eur J Ophthalmol. 2010;20:565-71 pubmed
    To evaluate the efficacy of C(3)F(8) gas-assisted pneumatic displacement in the treatment of massive submacular hemorrhage, with and without the use of tissue plasminogen activator (tPA).
  57. Berge E, Cohen G, Roaldsen M, Lundström E, Isaksson E, Rudberg A, et al. Effects of alteplase on survival after ischaemic stroke (IST-3): 3 year follow-up of a randomised, controlled, open-label trial. Lancet Neurol. 2016;15:1028-34 pubmed publisher
    The effect of alteplase on patient survival after ischaemic stroke is the subject of debate...
  58. Peyron M, Sante Lhoutellier V, Francois O, Hennequin M. Oral declines and mastication deficiencies cause alteration of food bolus properties. Food Funct. 2018;9:1112-1122 pubmed publisher
    ..bolus was measured by sieving and rheological features (hardness, cohesiveness and elasticity) were assessed with a TPA test...
  59. Jacob Ferreira A, Menaldo D, Bernardes C, Sartim M, de Angelis C, Tanus Santos J, et al. Evaluation of the in vivo thrombolytic activity of a metalloprotease from Bothrops atrox venom using a model of venous thrombosis. Toxicon. 2016;109:18-25 pubmed publisher
    ..The prescription medication Alteplase (tissue-type plasminogen activator) was used as positive control for thrombolytic activity, while saline was ..
  60. Passeri D, Doldo E, Tarquini C, Costanza G, Mazzaglia D, Agostinelli S, et al. Loss of CRABP-II Characterizes Human Skin Poorly Differentiated Squamous Cell Carcinomas and Favors DMBA/TPA-Induced Carcinogenesis. J Invest Dermatol. 2016;136:1255-66 pubmed publisher
    ..Therapeutic interventions aimed at restoring CRABP-II-mediated signaling may amplify therapeutic retinoid efficacy in nonmelanoma skin cancer. ..
  61. Nonaka A, Yoshida M, Iha M, Kubo Y, Kihara Y, Kikuchi T, et al. Exogenous expression of homeoprotein EGAM1N prevents in vitro cardiomyogenesis by impairing expression of T and Nkx2.5, but not Mef2c, in mouse embryonic stem cells. Cytotechnology. 2016;68:2431-2436 pubmed
    ..Conversely, the expression levels of Gata6 and Plat, markers for the primitive endoderm lineage, and Cdx2, a marker for the trophectoderm lineage, were increased...
  62. Nilsson E, Alfredsson V, Bowron D, Edler K. A neutron scattering and modelling study of aqueous solutions of tetramethylammonium and tetrapropylammonium bromide. Phys Chem Chem Phys. 2016;18:11193-201 pubmed publisher
    ..the properties in water of two tetraalkylammonium bromides (tetramethylammonium, TMA(+), and tetrapropylammonium, TPA(+)), at 0...
  63. Jia J, Zhang Y, Zheng M, Shan C, Yan H, Wu W, et al. Functionalized Eu(III)-Based Nanoscale Metal-Organic Framework To Achieve Near-IR-Triggered and -Targeted Two-Photon Absorption Photodynamic Therapy. Inorg Chem. 2017;: pubmed publisher
    ..Herein, a Eu(III)-based NMOF probe elaborately postsynthetically modified with a ?-diketonate two-photon-absorbing (TPA) ligand is rationally designed and further functionalized by assembling the photosensitizer molecule (methylene ..
  64. Yuan G, Zheng X, Chen K. [Combined surgical approaches in the treatment of complex tibial plateau fractures]. Zhongguo Gu Shang. 2017;30:89-92 pubmed publisher
    ..The X-ray healing time and knee joint mobility were recorded. The mean tibial plateau angle(TPA) and the mean posterior slope angle (PA) were measured and recorded immediately after operation, 6 and 12 months ..
  65. Pannekoek H, van Meijer M, Schleef R, Loskutoff D, Barbas C. Functional display of human plasminogen-activator inhibitor 1 (PAI-1) on phages: novel perspectives for structure-function analysis by error-prone DNA synthesis. Gene. 1993;128:135-40 pubmed
    ..The method described here is applicable to other studies on the structure-function analysis of eukaryotic proteins. ..
  66. Brodsky S, Chen J, Lee A, Akassoglou K, Norman J, Goligorsky M. Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis. Am J Physiol Heart Circ Physiol. 2001;281:H1784-92 pubmed
    ..the necessary and sufficient components of the PA system [PAI-1, urokinase-type PA (uPA), or tissue-type PA (tPA), and plasminogen (Plg)] for angiogenesis, we examined angiogenic competence of vascular explant cultures obtained ..
  67. Muller H, Lindman A, Blomfeldt A, Seljeflot I, Pedersen J. A diet rich in coconut oil reduces diurnal postprandial variations in circulating tissue plasminogen activator antigen and fasting lipoprotein (a) compared with a diet rich in unsaturated fat in women. J Nutr. 2003;133:3422-7 pubmed
    ..The proportions of dietary saturated fatty acids more than the percentage of saturated fat energy seem to have a beneficial influence on Lp(a) levels. ..
  68. Jern C, Blomstrand C, Westerlind A. Evidence of a net release of tissue-type plasminogen activator across the human cerebral vasculature. Thromb Haemost. 2004;91:1019-25 pubmed
    ..The results show that there is a basal net release of t-PA across the human cerebral vascular bed and that sympathoadrenal activation induces a local regulated release of t-PA. ..
  69. Hoppe B, Tolou F, Dorner T, Kiesewetter H, Salama A. Gene polymorphisms implicated in influencing susceptibility to venous and arterial thromboembolism: frequency distribution in a healthy German population. Thromb Haemost. 2006;96:465-70 pubmed
  70. Hafer Macko C, Ivey F, Sorkin J, Macko R. Microvascular tissue plasminogen activator is reduced in diabetic neuropathy. Neurology. 2007;69:268-74 pubmed
    ..macrovascular disease; whether key vascular endothelial regulatory proteins, such as tissue plasminogen activator (tPA), are altered in diabetic neuropathy microvasculature is unknown...
  71. Cops E, Sashindranath M, Daglas M, Short K, da Fonseca Pereira C, Pang T, et al. Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait. Exp Neurol. 2013;249:8-19 pubmed publisher
    ..A correlation between Purkinje degeneration and excess cerebellar levels of tissue-type plasminogen activator (tPA) has been observed in multiple genetically-distinct models of ataxia...
  72. Novotny D, Karasek D, Vaverkova H, Slavik L. The influence of apolipoprotein A5 T-1131C and apolipoprotein E common genetic variants on the levels of hemostatic markers in dyslipidemic patients. Clin Chim Acta. 2014;436:11-7 pubmed publisher
    ..The -1131C Apo A5 minor variant was associated with elevated tissue plasminogen activator (tPA) in comparison to TT genotype (p<0.001), but not in the MetS+ group...
  73. Girod P, Hartmann S, Kavakebi P, Obernauer J, Verius M, Thome C. Asymmetric pedicle subtractionosteotomy (aPSO) guided by a 3D-printed model to correct a combined fixed sagittal and coronal imbalance. Neurosurg Rev. 2017;40:689-693 pubmed publisher
    ..preoperatively (pelvic incidence 47° [PI], lumbar lordosis 18° [LL]; pelvic tilt 42° [PT], T1 pelvic angle 40° [TPA], Cobb angle 33°, sagittal vertical axis 10.5 cm [SVA])...
  74. Hsieh H, Chen Y, Jhan J, Lin J. The serine protease inhibitor serpinB2 binds and stabilizes p21 in senescent cells. J Cell Sci. 2017;130:3272-3281 pubmed publisher
    ..documented that serpinB2 is an inhibitor of urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA)...
  75. Diosdado A, Gómez P, Morchón R, Simón F, González Miguel J. Interaction between Wolbachia and the fibrinolytic system as a possible pathological mechanism in cardiopulmonary dirofilariosis. Vet Parasitol. 2017;247:64-69 pubmed publisher
  76. Andreu I, Morera I, Palumbo F, Sastre G, Bosca F, Miranda M. Steric shielding vs. ?-? orbital interactions in triplet-triplet energy transfer. Chem Sci. 2015;6:4035-4041 pubmed publisher
    ..diaryl ketones of ?,?* electronic configuration tethered to ?- or ?-Ch were prepared from tiaprofenic acid (TPA) and suprofen (SUP)...
  77. Leube R, Bosch F, Romano V, Zimbelmann R, Hofler H, Franke W. Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ. Differentiation. 1986;33:69-85 pubmed
    ..Comparison with the reported amino acid sequences of two fragments of human 'tissue polypeptide antigen' (TPA), a widely used serodiagnostic carcinoma marker, revealed sequence identity, indicating that this serum component ..
  78. Byeon I, Kelley R, Llinas M. 1H NMR structural characterization of a recombinant kringle 2 domain from human tissue-type plasminogen activator. Biochemistry. 1989;28:9350-60 pubmed
    ..abstract truncated at 400 words) ..
  79. Heegaard C, Rasmussen L, Andreasen P. The plasminogen activation system in bovine milk: differential localization of tissue-type plasminogen activator and urokinase in milk fractions is caused by binding to casein and urokinase receptor. Biochim Biophys Acta. 1994;1222:45-55 pubmed
    ..R. and Tritsch, G.L. (1993) Fibrinolysis 7, 229-236), and the observed t-PA/casein binding suggests that the casein micelle, which also contains plasminogen, may serve as a matrix for t-PA-catalyzed plasminogen activation in milk. ..
  80. Spence M, Streiff R, Day D, Ma Y. Oncostatin M induces tissue-type plasminogen activator and plasminogen activator inhibitor-1 in Calu-1 lung carcinoma cells. Cytokine. 2002;18:26-34 pubmed
    ..This study revealed OSM-mediated expression of mRNAs encoding tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1)...
  81. Ulfhammer E, Carlström M, Bergh N, Larsson P, Karlsson L, Jern S. Suppression of endothelial t-PA expression by prolonged high laminar shear stress. Biochem Biophys Res Commun. 2009;379:532-6 pubmed publisher
    ..We conclude that prolonged high laminar shear stress suppresses endothelial t-PA expression and may therefore contribute to the enhanced risk of arterial thrombosis in hypertensive disease. ..
  82. Jiao J, Ishikawa T, Dumlao D, Norris P, Magyar C, Mikulec C, et al. Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer. Mol Cancer Res. 2014;12:1677-88 pubmed publisher
    ..and global gene deletion studies demonstrate that cyclooxygenase-2 (PTGS2/COX-2) plays a critical role in DMBA/TPA-induced skin tumor induction...
  83. Bertrand T, Lesept F, Chevilley A, Lenoir S, Aimable M, Briens A, et al. Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR. Cell Death Dis. 2015;6:e1924 pubmed publisher
    Tissue-type plasminogen activator (tPA) is a pleiotropic serine protease of the central nervous system (CNS) with reported neurotrophic and neurotoxic functions...
  84. Matsumoto H, Yoshida Y, Hirata Y. Usefulness of cervical magnetic resonance imaging for detecting type A acute aortic dissection with acute stroke symptoms. Magn Reson Imaging. 2016;34:902-7 pubmed publisher
    ..When intravenous tissue plasminogen activator (IV-tPA) therapy is considered for acute ischemic stroke, TAAAD must be excluded...
  85. Gebhart J, Kepa S, Hofer S, Koder S, Kaider A, Wolberg A, et al. Fibrinolysis in patients with a mild-to-moderate bleeding tendency of unknown cause. Ann Hematol. 2017;96:489-495 pubmed publisher
    ..Tissue plasminogen activator (tPA-) antigen and activity, plasminogen activator inhibitor type-1 (PAI-1), tPA-PAI-1 complexes, thrombin activatable ..
  86. Zhang Y, Hu W, Zhao L, Leng J, Ma H. Conjugation Length Effect on TPA-Based Optical Limiting Performance of a Series of Ladder-Type Chromophores. Materials (Basel). 2017;10: pubmed publisher
    ..The results also provide a method to modulate the optical limiting and dynamical two-photon absorption of the compounds by changing the molecular density and thickness of the absorber. ..
  87. Droege K, Keithly M, Sanders C, Armstrong R, Thompson M. Structural Dynamics of 15-Lipoxygenase-2 via Hydrogen-Deuterium Exchange. Biochemistry. 2017;56:5065-5074 pubmed publisher
    ..15-LOX contains two domains: a Ca2+ binding PLAT domain and a catalytic domain...
  88. Newton D, Kim C, Lee N, Wolfe L, Pfeifer J, Amendola M. Sarcopenia predicts poor long-term survival in patients undergoing endovascular aortic aneurysm repair. J Vasc Surg. 2018;67:453-459 pubmed publisher
    ..December 2010 to March 2016 at a Veterans Affairs hospital were assessed for sarcopenia by total psoas muscle area (TPA) measured on axial computed tomography scan immediately inferior to the fourth lumbar (L4) superior end plate...
  89. Chen J, Shao N, Zhang Y, Zhu Y, Yang L, Tao S. A visual multiplex PCR microchip with easy sample loading. Yi Chuan. 2017;39:525-534 pubmed publisher
    ..After the PCRmix is loaded, it would be placed on a plat thermal cycler for PCR...
  90. Garcias Morales C, Romero Borja D, Maldonado J, Roa A, Rodriguez M, García Merinos J, et al. Small Molecules Derived from Thieno[3,4-c]pyrrole-4,6-dione (TPD) and Their Use in Solution Processed Organic Solar Cells. Molecules. 2017;22: pubmed publisher
    ..microwave synthesis, chemical, optical and electrochemical characterization of three small organic molecules, TPA-TPD, TPA-PT-TPD and TPA-TT-TPD with donor-acceptor structure and their use in organic ..
  91. Rostanski S, Stillman J, Schaff L, Perdomo C, Liberman A, Miller E, et al. E-Mail Is an Effective Tool for Rapid Feedback in Acute Stroke. Neurohospitalist. 2017;7:159-163 pubmed publisher
    ..prompt, case-specific data feedback and improve door-to-needle (DTN) time for acute ischemic stroke treated with intravenous tissue plasminogen activator (IV-tPA) in the emergency department (ED) at a high-volume academic stroke center.
  92. Boose J, Kuismanen E, Gerard R, Sambrook J, Gething M. The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site. Biochemistry. 1989;28:635-43 pubmed
    ..This conversion, from the less active form of the enzyme, results in a reaction that displays biphasic kinetics.(ABSTRACT TRUNCATED AT 250 WORDS) ..