PLA2G6

Summary

Gene Symbol: PLA2G6
Description: phospholipase A2, group VI (cytosolic, calcium-independent)
Alias: CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, iPLA2, iPLA2beta, 85 kDa calcium-independent phospholipase A2, 85/88 kDa calcium-independent phospholipase A2, GVI PLA2, calcium-independent phospholipase A2, cytosolic, calcium-independent phospholipase A2, group VI phospholipase A2, iPLA2-beta, intracellular membrane-associated calcium-independent phospholipase A2 beta, neurodegeneration with brain iron accumulation 2, patatin-like phospholipase domain containing 9, patatin-like phospholipase domain-containing protein 9
Species: human

Top Publications

  1. doi Characterization of PLA2G6 as a locus for dystonia-parkinsonism
    Coro Paisan-Ruiz
    Laboratory of Neurogenetics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA
    Ann Neurol 65:19-23. 2009
  2. pmc PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron
    Neil V Morgan
    Section of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham B15 2TT, UK
    Nat Genet 38:752-4. 2006
  3. pmc Neurodegeneration associated with genetic defects in phospholipase A(2)
    A Gregory
    Department of Molecular and Medical Genetics, Oregon Health and Science University, L103A, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 3098, USA
    Neurology 71:1402-9. 2008
  4. ncbi Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:48968-75. 2004
  5. ncbi Fcgamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA2 but not cPLA2 in human monocytic cells
    Hwee Kee Tay
    Department of Physiology, Faculty of Medicine, National University of Singapore, Singapore 117597
    J Biol Chem 279:22505-13. 2004
  6. pmc Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi
    Mario Falchi
    Department of Twin Research and Genetic Epidemiology, Kings College London, St Thomas Hospital Campus, London, UK
    Nat Genet 41:915-9. 2009
  7. pmc ADP ribosylation factors 1 and 4 and group VIA phospholipase A₂ regulate morphology and intraorganellar traffic in the endoplasmic reticulum-Golgi intermediate compartment
    Houchaima Ben-Tekaya
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Mol Biol Cell 21:4130-40. 2010
  8. pmc Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 20:2673-9. 2011
  9. pmc PLA2G6 mutation underlies infantile neuroaxonal dystrophy
    Shareef Khateeb
    Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben Gurion University, Israel
    Am J Hum Genet 79:942-8. 2006
  10. pmc Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s Hospital, Beckett Street, Leeds, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:2043-54. 2010

Research Grants

Detail Information

Publications179 found, 100 shown here

  1. doi Characterization of PLA2G6 as a locus for dystonia-parkinsonism
    Coro Paisan-Ruiz
    Laboratory of Neurogenetics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA
    Ann Neurol 65:19-23. 2009
    ..Although many recessive loci causing parkinsonism dystonia have been identified, these do not explain all cases of the disorder...
  2. pmc PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron
    Neil V Morgan
    Section of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham B15 2TT, UK
    Nat Genet 38:752-4. 2006
    ..NBIA) to chromosome 22q12-q13 and identified mutations in PLA2G6, encoding a calcium-independent group VI phospholipase A2, in NBIA, INAD and the related Karak syndrome...
  3. pmc Neurodegeneration associated with genetic defects in phospholipase A(2)
    A Gregory
    Department of Molecular and Medical Genetics, Oregon Health and Science University, L103A, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 3098, USA
    Neurology 71:1402-9. 2008
    Mutations in the gene encoding phospholipase A(2) group VI (PLA2G6) are associated with two childhood neurologic disorders: infantile neuroaxonal dystrophy (INAD) and idiopathic neurodegeneration with brain iron accumulation (NBIA)...
  4. ncbi Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:48968-75. 2004
    ..Sequence data base searches for proteins containing calcium-independent phospholipase A2 (iPLA2) dual signature nucleotide ((G/A)XGXXG) and lipase (GXSXG) consensus sequence motifs identified a novel subfamily ..
  5. ncbi Fcgamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA2 but not cPLA2 in human monocytic cells
    Hwee Kee Tay
    Department of Physiology, Faculty of Medicine, National University of Singapore, Singapore 117597
    J Biol Chem 279:22505-13. 2004
    ....
  6. pmc Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi
    Mario Falchi
    Department of Twin Research and Genetic Epidemiology, Kings College London, St Thomas Hospital Campus, London, UK
    Nat Genet 41:915-9. 2009
    ..4 x 10(-15)), as well as in PLA2G6 on 22q13.1 (rs2284063, combined P = 3.4 x 10(-8))...
  7. pmc ADP ribosylation factors 1 and 4 and group VIA phospholipase A₂ regulate morphology and intraorganellar traffic in the endoplasmic reticulum-Golgi intermediate compartment
    Houchaima Ben-Tekaya
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Mol Biol Cell 21:4130-40. 2010
    ..Tubule formation was inhibited by an antagonist of group VI calcium-independent phospholipase A₂ (PLA2G6) and by silencing the A isoform of PLA2G6 (PLA2G6-A)...
  8. pmc Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 20:2673-9. 2011
    ..5 × 10(-6)) and in primary melanoma (P = 4.6 × 10(-4)) compared with the normal skin...
  9. pmc PLA2G6 mutation underlies infantile neuroaxonal dystrophy
    Shareef Khateeb
    Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben Gurion University, Israel
    Am J Hum Genet 79:942-8. 2006
    ..fraction 0 for SNP rs139897), and an underlying mutation common to both affected families was identified in PLA2G6, the gene encoding phospholipase A2 group VI (cytosolic, calcium-independent)...
  10. pmc Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s Hospital, Beckett Street, Leeds, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:2043-54. 2010
    ..Increased number of melanocytic nevi is a potent melanoma risk factor. We have carried out a large population-based case-control study to explore the environmental and genetic determinants of nevi and the relationship with melanoma risk...
  11. ncbi Cell cycle dependence of group VIA calcium-independent phospholipase A2 activity
    Alex D Manguikian
    Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0614, USA
    J Biol Chem 279:52881-92. 2004
    ..Together, these data suggest that truncated iPLA(2) proteins associate with active iPLA(2) and down-regulate its activity during G(1). This down-regulation may contribute to phospholipid accumulation during the cell cycle...
  12. ncbi A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifs
    J Tang
    Genetics Institute, Cambridge, Massachusetts 02140, USA
    J Biol Chem 272:8567-75. 1997
    ..the purification, molecular cloning, and expression of a novel cytosolic calcium-independent phospholipase A2 (iPLA2) from Chinese hamster ovary cells, which lacks extended homology to other phospholipases...
  13. doi Clinical study and PLA2G6 mutation screening analysis in Chinese patients with infantile neuroaxonal dystrophy
    Y Wu
    Department of Pediatrics, Peking University, First Hospital, Beijing, China
    Eur J Neurol 16:240-5. 2009
    ..Before the identification of associated mutations in PLA2G6-encoding iPLA(2)-VIA (cytosolic Ca(2+)-independent phospholipids A(2), group VIA) in 2006, neuropathological ..
  14. pmc iPLA2beta: front and center in human monocyte chemotaxis to MCP-1
    Ravi S Mishra
    Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA
    J Exp Med 205:347-59. 2008
    ....
  15. pmc Beta-cell calcium-independent group VIA phospholipase A(2) (iPLA(2)beta): tracking iPLA(2)beta movements in response to stimulation with insulin secretagogues in INS-1 cells
    Shunzhong Bao
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 53:S186-9. 2004
    ..Arachidonic acid produced by iPLA(2)beta-catalyzed hydrolysis of their substrates induces release of Ca(2+) from ER stores-an event thought to participate in glucose-stimulated insulin secretion...
  16. pmc Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22
    Z Ma
    Mass Spectrometry Resource, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 274:9607-16. 1999
    An 85-kDa Group VI phospholipase A2 enzyme (iPLA2) that does not require Ca2+ for catalysis has recently been cloned from three rodent species...
  17. doi R632W mutation in PLA2G6 segregates with dystonia-parkinsonism in a consanguineous Iranian family
    F Sina
    Iran University of Medical Sciences, Hazrat Rasool Hospital, Tehran, Iran
    Eur J Neurol 16:101-4. 2009
    b>PLA2G6 mutations are known to be responsible for infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation (NBIA)...
  18. ncbi Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity
    P K Larsson
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Biol Chem 273:207-14. 1998
    Recently, the cloning of a novel Ca2+-independent phospholipase A2 (iPLA2) from Chinese hamster ovary cells as well as from mouse and rat sources containing a C-terminal lipase motif and eight N-terminal ankyrin repeats has been ..
  19. ncbi Activation mechanism for CRAC current and store-operated Ca2+ entry: calcium influx factor and Ca2+-independent phospholipase A2beta-mediated pathway
    Peter Csutora
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 281:34926-35. 2006
    ..net loss) as well as by simple buffering of free Ca2+ within the stores, 2) a specific 82-kDa variant of iPLA2beta and its corresponding activity are present in membrane fraction of RBL cells, 3) exogenous CIF (extracted from ..
  20. pmc Inhibition of carrageenin-induced rat paw oedema by crotapotin, a polypeptide complexed with phospholipase A2
    E C Landucci
    Department of Biochemistry, UNICAMP, Campinas SP, Brazil
    Br J Pharmacol 114:578-83. 1995
    ..effect of purified crotapotin, a non-toxic non-enzymatic chaperon protein normally complexed to a phospholipase A2 (PLA2) in South America rattlesnake venom, was studied in the acute inflammatory response induced by carrageenin (1 mg/..
  21. pmc Differential changes of adrenoceptor- and muscarinic receptor-linked prostacyclin synthesis by the aorta and urinary bladder of the diabetic rat
    J Y Jeremy
    Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, University of London
    Br J Pharmacol 108:1131-6. 1993
    ..Ca2+ ionophore A23187 (A23187) and thapsigargin (both elevate intracellular Ca2+, activating phospholipase A2 [PLA2]) and arachidonate (AA; substrate for PGI2 synthesis). 2...
  22. pmc Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carrageenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2
    A Miyake
    Molecular and Cellular Pharmacology, Dept, Yamanouchi Pharmaceutical Co Ltd, Tokyo, Japan
    Br J Pharmacol 110:447-53. 1993
    ..eny l) chroman] dose-dependently inhibited the activities of extracellular phospholipase A2 (PLA2): rabbit platelet-derived group II and porcine pancreas-derived group I PLA2, with IC50 values of 0.085 (0.056-0...
  23. ncbi Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI
    D W Snyder
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 288:1117-24. 1999
    LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, LY315920 inhibited sPLA2 activity with an IC50 of 9 +/- 1 nM or 7...
  24. pmc Up-regulation of [3H]-des-Arg10-kallidin binding to the bradykinin B1 receptor by interleukin-1 beta in isolated smooth muscle cells: correlation with B1 agonist-induced PGI2 production
    J P Galizzi
    Cerep, Celle l evescault, France
    Br J Pharmacol 113:389-94. 1994
    ..This observation suggests that IL-1 but not LPS, in addition to increase in the number of receptors, signals the cell to permit the coupling of B1 receptors to the PLA2/cyclo-oxygenase pathway.
  25. ncbi Arachidonic acid induces c-jun gene expression in stromal cells stimulated by interleukin-1 and tumor necrosis factor-alpha: evidence for a tyrosine-kinase-dependent process
    M T Rizzo
    Division of Hematology and Bone Marrow Transplantation, Parma University School of Medicine, Italy
    Blood 86:2967-75. 1995
    ..1-LDA 11 involves activation of phospholipase A2 (PLA2)...
  26. ncbi Intracerebral injection of phospholipase A2 inhibits dopamine-mediated behavior in rats: possible implications for schizophrenia
    J Brunner
    Neurobiology Unit, Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 246:13-6. 1995
    Phospholipase A2 (PLA2) is a key enzyme in the phospholipid metabolism. In the CNS intracellular PLA2 plays an essential role in signal transduction by affecting both dopamine (DA) release and DA-receptor sensitivity...
  27. ncbi Activation of BK channels in GH3 cells by a c-PLA2-dependent G-protein signaling pathway
    D D Denson
    Dept of Anesthesiology, Emory University School of Medicine, 3B South Emory University Hospital, 1364 Clifton Rd, Atlanta, GA 30322, USA
    J Neurophysiol 93:3146-56. 2005
    BK-channels in GH3 cells are activated by arachidonic acid produced by c-PLA2. beta-adrenergic agonists also activate BK channels and were presumed to do so via production of cAMP...
  28. ncbi Affinity purification of phospholipase A2 on immobilized artificial membranes containing and lacking the glycerol backbone
    C Bernal
    Department of Medicinal Chemistry, School of Pharmacy, Perdue University, West Lafayette, IN 47907, USA
    J Chromatogr A 731:139-51. 1996
    ..PCC10/C3 lacks the glycerol backbone. Affinity purification of PLA2 on these IAM surfaces demonstrated that the surface structural differences were not important for phospholipase A2 (..
  29. pmc Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation
    Barry M Markaverich
    Department of Molecular and Cellular Biology, Baylor Colloege of Medicine, Houston, TX 77030, USA
    Environ Health Perspect 115:1727-31. 2007
    ..Synthetic THF-diols inhibited rat male and female sexual behavior at oral concentrations of 0.5-1 ppm, and stimulated MCF-7 human breast cancer cell proliferation in vitro...
  30. ncbi Decreased phospholipase A2 activity in the brain and in platelets of patients with Alzheimer's disease
    W F Gattaz
    Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 246:129-31. 1996
    Phospholipase A2 (PLA2) is a key enzyme in the metabolism of membrane phospholipids...
  31. pmc Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin production
    James D Godkin
    Department of Animal Science, The University of Tennessee, Knoxville, TN, USA
    Reprod Biol Endocrinol 6:44. 2008
    ..The objectives of this investigation were to evaluate the expression and activities of calcium-dependent group IVA (PLA2G4A) and calcium-independent group VI (PLA2G6) enzymes in the regulation of BEND cell PG production.
  32. ncbi Pancreatic phospholipase A2--mediated enhancement of the respiratory burst response of human neutrophils
    J Muller
    Institute of Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Germany
    Z Naturforsch C 56:1150-6. 2001
    ..Pancreatic PLA2 was used because PMNs do not possess a receptor for that enzyme and, therefore, the receptor-mediated effects could ..
  33. ncbi Chymopapain-induced reduction of proinflammatory phospholipase A2 activity and amelioration of neuropathic behavioral changes in an in vivo model of acute sciatica
    P D Sawin
    Department of Pathology, The University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    J Neurosurg 86:998-1006. 1997
    ..assessed the ability of chymopapain to modulate the activity of the proinflammatory enzyme phospholipase A2 (PLA2) and to ameliorate behavioral changes associated with inflammatory neuropathy in an in vivo model of sciatica...
  34. ncbi Semisynthetic preparation of 1-O-hexadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor)
    M E Lekka
    Department of Chemistry, University of Ioannina, Greece
    Z Naturforsch C 43:665-70. 1988
    ..the chromatographic behaviour on TLC and HPLC, the physicochemical properties and the behaviour under treatment with PLA2 and Lipase from Rhizopus arrhizus. The above procedure is proposed as a facile, inexpensive and convenient method.
  35. ncbi Progesterone primes zona pellucida-induced activation of phospholipase A2 during acrosomal exocytosis in guinea pig spermatozoa
    Qi Xian Shi
    Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, People s Republic of China
    J Cell Physiol 205:344-54. 2005
    We investigated, using guinea-pig spermatozoa as a model, whether phospholipase A2 (PLA2) is involved in progesterone or zona pellucida (ZP)-stimulated acrosomal exocytosis, if progesterone enhances ZP-induced activation of PLA2, and ..
  36. ncbi Effect of neuroleptics on phospholipase A2 activity in the brain of rats
    H I Trzeciak
    Department of Pharmacology, Silesian Academy of Medicine, Katowice-Ligota, Poland
    Eur Arch Psychiatry Clin Neurosci 245:179-82. 1995
    The effect of neuroleptics on phospholipase A2 (PLA2) activity in rat brain plasma membranes was studied...
  37. doi CC-PLA2-1 and CC-PLA2-2, two Cerastes cerastes venom-derived phospholipases A2, inhibit angiogenesis both in vitro and in vivo
    Raoudha Kessentini-Zouari
    Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Tunis, Tunisia
    Lab Invest 90:510-9. 2010
    ..Here, we report that CC-PLA2-1 and CC-PLA2-2, two novel secreted phospholipases A(2) (PLA(2)) isolated from Cerastes cerastes venom, also showed ..
  38. pmc Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2
    Ji Fu Wei
    Clinical Experiment Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China
    BMC Immunol 10:21. 2009
    It has been recognized that phospholipase A2 (PLA2) is a crucial component of snake venom, which contributes greatly to snake venom induced inflammation in man...
  39. ncbi Oxalate toxicity in renal cells
    Julie A Jonassen
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Urol Res 33:329-39. 2005
    ..Oxalate exposure activates phospholipase A2 (PLA2), which increases two lipid signaling molecules, arachidonic acid and lysophosphatidylcholine (Lyso-PC)...
  40. ncbi Effect of a new inhibitor of type II phospholipase A2 on experimental acute pancreatitis in rats
    T Yoshikawa
    Department of Internal Medicine II, Nagoya University School of Medicine, Japan
    Pancreas 19:193-8. 1999
    The catalytic activity of type II phospholipase A2 (PLA2) in blood has been reported to increase in acute pancreatitis and to reflect the severity of pancreatitis...
  41. ncbi Mobile phase effects on membrane protein elution during immobilized artificial membrane chromatography
    C Pidgeon
    Department of Medicinal Chemistry, School of Pharmacy, Purdue University, West Layfayette, IN 47907, USA
    J Chromatogr A 721:213-30. 1996
    ..Two protein mixtures containing bovine pancreatic PLA2 were used in this study...
  42. ncbi Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Free Radic Biol Med 40:364-75. 2006
    Phospholipases A2 (PLA2) comprise a set of extracellular and intracellular enzymes that catalyze the hydrolysis of the sn-2 fatty acyl bond of phospholipids to yield fatty acids and lysophospholipids...
  43. ncbi Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2
    E C Landucci
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil
    Toxicon 38:199-208. 2000
    ..The ability of crotapotin to affect the enzymatic activity of the sPLA2(s) have also been evaluated. Secretory PLA2(s) obtained from both snake (Naja naja, Naja mocambique mocambique, Crotalus adamanteus and Crotalus durissus ..
  44. doi Purification, characterization and bactericidal activities of basic phospholipase A2 from the venom of Agkistrodon halys (Chinese pallas)
    R Perumal Samy
    Venom and Toxin Research Programme, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Biochimie 90:1372-88. 2008
    Agkistrodon snake venoms contain a variety of phospholipases (PLA2), some of which are myotoxic. In this study, we used reverse-phase HPLC to purify PLA2 from the venom of Agkistrodon halys...
  45. ncbi Phospholipase A2 is present in meconium and inhibits the activity of pulmonary surfactant: an in vitro study
    A J Schrama
    Department of Pediatrics, Leiden University Medical Center, The Netherlands
    Acta Paediatr 90:412-6. 2001
    ..g. fatty acids, inhibit surfactant activity. However, the role of the enzyme phospholipase A2 (PLA2), which hydrolyses surfactant in adult respiratory distress syndrome (ARDS), has not yet been studied...
  46. ncbi Ca2+-independent phospholipase A2 contributes to the insulinotropic action of cholecystokinin-8 in rat islets: dissociation from the mechanism of carbachol
    E Simonsson
    Department of Medicine, Lund University, Malmo, Sweden
    Diabetes 47:1436-43. 1998
    Insulin secretion induced by cholecystokinin-8 (CCK-8) was recently suggested to involve phospholipase A2 (PLA2) activation...
  47. ncbi Role of various phospholipases A2 and inhibitors in the pathogenesis and prevention of pancreatic acinar cell necrosis: studies with isolated rat pancreatic acini
    J MOssner
    Department of Internal Medicine II, University of Leipzig, Germany
    Int J Pancreatol 27:29-38. 2000
    Phospholipase A2 (PLA2) may play a central role in the pathogenesis of pancreatic acinar cell necrosis...
  48. ncbi Inhibition of phospholipase A2 (PLA2) activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity
    J Chang
    Department of Experimental Therapeutics, Wyeth Laboratories, Inc, Philadelphia, Pennsylvania 19101
    Inflammation 11:353-64. 1987
    The effects of several calcium antagonists on phospholipase A2 (PLA2) activity were examined...
  49. ncbi Purification, characterization, and molecular cloning of group I phospholipases A2 from the gills of the red sea bream, Pagrus major
    N Iijima
    Faculty of Applied Biological Science, Hiroshima University, Higashihiroshima, Japan
    Lipids 35:1359-70. 2000
    Phospholipase A2 (PLA2) activity was investigated in various tissues of male and female red sea bream...
  50. ncbi CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792 3232, USA
    J Biol Chem 281:6718-25. 2006
    ..PtdCho is hydrolyzed by phospholipase A2 (PLA2), PtdChospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD)...
  51. ncbi Cyclic stretch-induced cPLA2 mediates ERK 1/2 signaling in rabbit proximal tubule cells
    Larry D Alexander
    Department of Medicine, Division of Nephrology and Hypertension, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106 4982, USA
    Kidney Int 65:551-63. 2004
    Recent evidence from this laboratory have demonstrated a critical role of phospholipase A2 (PLA2) and arachidonic acid in angiotensin II type 2 (AT2) receptor-mediated kinase activation in renal epithelium independent of phosphoinositide- ..
  52. ncbi Thiol-oxidizing agent diamide and acidic pH enhance lipid peroxidation of rat heart mitochondria and cardiolipin-cytochrome c complex
    H Iwase
    Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, Japan
    IUBMB Life 51:39-43. 2001
    In this study, we investigated lipid peroxidation in rat heart mitochondria hydrolyzed by phospholipase A2 (PLA2) and lipid peroxidation in a mitochondrial-mimetic lipid peroxidation system, where phospholipids such as cardiolipin (CL) ..
  53. pmc Modulation of the pharmacological effects of enzymatically-active PLA2 by BTL-2, an isolectin isolated from the Bryothamnion triquetrum red alga
    Simone Cb Oliveira
    Biochemistry Department, Biology Institute, UNICAMP, Campinas, Sao Paulo, Brazil
    BMC Biochem 9:16. 2008
    An interaction between lectins from marine algae and PLA2 from rattlesnake was suggested some years ago...
  54. ncbi Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachido
    Won K Han
    Medical Services, Massachusetts General Hospital, Department of Medicine and Anesthesia, Harvard Medical School, Massachusetts, USA
    J Biol Chem 278:24153-63. 2003
    Oxidant stress and phospholipase A2 (PLA2) activation have been implicated in numerous proinflammatory responses of the mesangial cell (MC)...
  55. ncbi Porcine pancreatic phospholipase A2 stimulates secretin release from secretin-producing cells
    T M Chang
    Konar Center for Digestive and Liver Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 274:10758-64. 1999
    ..with secretin-releasing activity that had N-terminal sequence homology with canine pancreatic phospholipase A2 (PLA2)...
  56. ncbi Phospholipase A2 in cnidaria
    Timo J Nevalainen
    Department of Pathology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Comp Biochem Physiol B Biochem Mol Biol 139:731-5. 2004
    Phospholipase A2 (PLA2) is an enzyme present in snake and other venoms and body fluids...
  57. ncbi Protein kinase Calpha-dependent increase in Ca2+-independent phospholipase A2 in membranes and arachidonic acid liberation in zymosan-stimulated macrophage-like P388D1 cells
    Satoshi Akiba
    Department of Pathological Biochemistry, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, 607 8414, Kyoto, Japan
    Biochem Pharmacol 63:1969-77. 2002
    ..kinase C (PKC)-dependent arachidonic acid liberation occurs with association of Ca2+-independent phospholipase A2 (iPLA2) with the membranes of macrophage-like P388D1 cells...
  58. doi The role of lipoprotein-associated phospholipase A2 in atherosclerosis may depend on its lipoprotein carrier in plasma
    Constantinos C Tellis
    Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
    Biochim Biophys Acta 1791:327-38. 2009
    ..in plasma is complexed to lipoproteins; thus it is also referred to as lipoprotein-associated phospholipase A2 (Lp-PLA2)...
  59. ncbi Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPL
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:32807-14. 2002
    ....
  60. ncbi Coupling reaction and properties of poly(ethylene glycol)-linked phospholipases A2
    Ismael D Bianco
    CEPROCOR Agencia Córdoba Ciencia S E, Argentina
    Biosci Biotechnol Biochem 66:722-9. 2002
    Secretory phospholipases A2 (PLA2) from Naja naja naja (cobra snake) venom, from Bothrops neuwiedii (crotalid snake) venom (two isoforms) and from bee venom were modified with tresylated monomethoxy poly(ethylene glycol) (TMPEG)...
  61. ncbi BE-I-PLA2, a novel acidic phospholipase A2 from Bothrops erythromelas venom: isolation, cloning and characterization as potent anti-platelet and inductor of prostaglandin I2 release by endothelial cells
    Jeanne Claine de Albuquerque Modesto
    Laboratorio de Bioquimica e Biofisica, Instituto Butantan, Sao Paulo SP, Brazil
    Biochem Pharmacol 72:377-84. 2006
    ..BE-I-PLA2 present a molecular weight of 13,649.57 Da as estimated by mass spectrometry...
  62. ncbi Effects of scalaradial, a type II phospholipase A2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation
    L A Marshall
    Department of Inflammation and Respiratory Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania
    J Pharmacol Exp Ther 268:709-17. 1994
    ..SLD potently inhibited human recombinant (rh) type II-14 kDa-phospholipase A2 (PLA2) (IC50 = 0.07 microM) but displayed weak inhibition of U937 cell, 85 kDa-PLA2 (IC50 = 20 microM)...
  63. ncbi Binding of quinacrine to acidic phospholipids and pancreatic phospholipase A2. Effects on the catalytic activity of the enzyme
    P Mustonen
    Institute of Biomedicine, Department of Medical Chemistry, University of Helsinki, Finland
    Biochemistry 37:12051-7. 1998
    Binding of quinacrine to phospholipids and porcine pancreatic phospholipase A2 (PLA2) was investigated using fluorescence resonance energy transfer, Langmuir films, assay for the enzymatic activity, and molecular modeling...
  64. pmc The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity
    Clive Gentry
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Mol Pain 6:4. 2010
    ..of TRPM8 by icilin and cold, but not menthol, is dependent on the activity of a sub-type of phospholipase A2, iPLA2. Lysophospholipids (e.g. LPC) produced by PLA2 activity can also activate TRPM8...
  65. ncbi Role of an aprotinin-sensitive protease in protein kinase Calpha-mediated activation of cytosolic phospholipase A2 by calcium ionophore (A23187) in pulmonary endothelium
    Sajal Chakraborti
    Department of Biochemistry and Biophysics, University of Kalyani, Kalyani 741235, West Bengal, India
    Cell Signal 16:751-62. 2004
    ..of the cells with arachidonyl-trifluomethylketone (AACOCF3), a cPLA2 inhibitor, but not bromoenollactone (BEL), a iPLA2 inhibitor, prevents A23187 stimulated PLA2 activity and AA release without producing an appreciable alteration of ..
  66. ncbi PLA2 mediated arachidonate free radicals: PLA2 inhibition and neutralization of free radicals by anti-oxidants--a new role as anti-inflammatory molecule
    B L Nanda
    Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India
    Curr Top Med Chem 7:765-77. 2007
    ..PLA2 enzymes have been classified into calcium dependent cPLA2 and sPLA2 and calcium independent iPLA2 forms. In several inflammatory diseases sPLA2 group IIA is the most abundant isoform identified...
  67. pmc Role of arachidonic acid and its metabolites in the priming of NADPH oxidase in human polymorphonuclear leukocytes by peritoneal dialysis effluent
    I Daniels
    Medical Research Centre, City Hospital, Nottingham, United Kingdom
    Clin Diagn Lab Immunol 5:683-9. 1998
    ..solute that will activate and prime the NADPH oxidase of human neutrophils via a phospholipase A2 (PLA2)-dependent mechanism...
  68. ncbi Synergistic effect of type II phospholipase A2 and platelet-activating factor on Mac-1 surface expression and exocytosis of gelatinase granules in human neutrophils: evidence for the 5-lipoxygenase-dependent mechanism
    J Takasaki
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Tsukuba, Ibaraki, Japan
    J Immunol 160:5066-72. 1998
    ..Type II phospholipase A2 (PLA2-II) also induces translocation of Mac-1 from secretory vesicles...
  69. ncbi Anti-masculinizing action of estradiol and cyproterone acetate: regulation of a protein fraction with phospholipase-A2 stimulatory and masculinizing activities
    C Gupta
    Department of Pediatric Nephrology, Children s Hospital of Pittsburgh, School of Medicine, University of Pittsburgh, PA 15213
    J Steroid Biochem Mol Biol 37:661-7. 1990
    ..55-63 K) from male and testosterone-exposed female mouse genital tract, which stimulates phospholipase A2 (PLA2) and induces masculine differentiation in an undifferentiated mouse genital explant, suggesting a role of this ..
  70. pmc Expression of PLA2G6 in human fetal development: Implications for infantile neuroaxonal dystrophy
    Brenda Polster
    Molecular and Medical Genetics, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States
    Brain Res Bull 83:374-9. 2010
    Mutations in PLA2G6, which encodes calcium-independent phospholipase A(2) group VIA (iPLA2-VIA), underlie the autosomal recessive disorder infantile neuroaxonal dystrophy (INAD)...
  71. ncbi Low and high density lipoprotein--cholesterol and coronary atherothrombosis
    Vladimir Kanjuh
    Cardiovascular Pathology, University School of Medicine Postgraduate, 11000 Belgrade, Dobracina 12
    Med Pregl 62:7-14. 2009
    ..Edwards and R. Virmani), the authors described the P. Libby's data on lipoprotein-associated phospholipaseA2 (Lp-PLA2) and its two inflammatory mediators: lysophosphatidylcholine and oxidized nonesterified fatty acids...
  72. pmc Fusion of neurotransmitter vesicles with target membrane is calcium independent in a cell-free system
    U O Karli
    Friedrich Miescher Institut, Basel, Switzerland
    Proc Natl Acad Sci U S A 87:5912-5. 1990
    ..in vitro by using chromaffin granules (CGs) and target membrane vesicles and a Ca2(+)-dependent phospholipase A2 (PLA2). Vesicle fusion is measured by a fluorescence dequenching assay with octadecyl rhodamine B used as the marker...
  73. doi Fenofibrate reduces lipoprotein associated phospholipase A2 mass and oxidative lipids in hypertriglyceridemic subjects with the metabolic syndrome
    Robert S Rosenson
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48106 0636, USA
    Am Heart J 155:499.e9-16. 2008
    Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a macrophage-synthesized lipase that is primarily bound to small electronegative low-density lipoproteins (LDLs)...
  74. ncbi Complement-induced phospholipase A2 activation in experimental membranous nephropathy
    A V Cybulsky
    Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
    Kidney Int 57:1052-62. 2000
    ..By analogy, in cultured rat GEC, sublytic C5b-9 injures plasma membranes and releases arachidonic acid (AA) and eicosanoids, due to activation of phospholipase A2 (PLA2). This study addresses the mechanisms of PLA2 activation.
  75. ncbi Group VI phospholipases A2: homeostatic phospholipases with significant potential as targets for novel therapeutics
    W P Wilkins
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Box 980614, Richmond, VA 23298, USA
    Curr Drug Targets 9:683-97. 2008
    b>Group VI phospholipase A2 (PLA2) is a family of acyl hydrolases that targets the sn-2 fatty acid on the glycerophospholipid (GPL) backbone...
  76. doi Phenotypic spectrum of neurodegeneration associated with mutations in the PLA2G6 gene (PLAN)
    M A Kurian
    Department of Pediatric Neurology, Birmingham Children s Hospital, Birmingham, UK
    Neurology 70:1623-9. 2008
    ..This group includes patients with recently discovered mutations in the PLA2G6 gene encoding a calcium-independent phospholipase A2 enzyme that catalyzes the hydrolysis of glycerophospholipids...
  77. ncbi Effects of long-term ursodeoxycholate administration on expression levels of secretory low-molecular-weight phospholipases A2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones
    M Kano
    Department of Gastroenterology, Institute of Clinical Medicine, The University of Tsukuba, Ibaraki, Japan
    Hepatology 28:302-13. 1998
    Group IIA phospholipase A2 (PLA2), a secretory low-molecular-weight PLA2, may play a critical role in the process of gallbladder mucosal inflammation in multiple cholesterol stones, which in turn may produce biliary pronucleating proteins ..
  78. ncbi Analysis of the secretory phospholipase A2 that mediates prostaglandin production in mast cells
    S T Reddy
    Department of Biological Chemistry, UCLA Center for the Health Sciences, Los Angeles, California 90095 1570, USA
    J Biol Chem 272:13591-6. 1997
    ..Early phase PGD2 synthesis in activated mast cells also requires the activity of a secretory phospholipase A2 (PLA2)...
  79. ncbi The structural variations of epsilon-amino groups in phospholipase A2 enzymes from Naja naja atra and Bungarus multicinctus venoms
    L S Chang
    Department of Biochemistry, Kaohsiung Medical College, Taiwan, ROC
    J Protein Chem 16:133-7. 1997
    Comparative studies on Naja naja atra phospholipase A2 (NNA-PLA2), Bungarus multicinctus phospholipase A2 (BM-PLA2), and their Lys-modified derivatives were made to assess the differences in the fine structures around the conserved Lys ..
  80. doi Platelet glycoprotein IIIa (platelet antigen 1/platelet antigen 2) polymorphism and 1-year outcome in patients with stable coronary artery disease
    Faouzi Addad
    Department of Cardiology A, Fattouma Bourguiba University Hospital, Monastir, Tunisia
    Blood Coagul Fibrinolysis 21:674-8. 2010
    ..controversy regarding the clinical impact of glycoprotein IIIa platelet antigen 1 (PlA1)/platelet antigen 2 (PlA2) polymorphism as a risk factor for myocardial infarction...
  81. ncbi Protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis
    Xi Ping Zhang
    Department of General Surgery, Hangzhou First People s Hospital, 261 Huansha Road, Hangzhou 310006, Zhejiang University School of Medicine, China
    World J Gastroenterol 13:5079-89. 2007
    ..To investigate the protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis (SAP)...
  82. pmc The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing
    P J Newman
    Blood Center of Southeastern Wisconsin, Milwaukee 53233
    J Clin Invest 83:1778-81. 1989
    The human platelet alloantigens, PlA1 and PlA2, comprise a diallelic antigen system located on a component of the platelet fibrinogen receptor, membrane glycoprotein (GP) IIIa...
  83. ncbi Expression of members of the phospholipase A2 family of enzymes in human nasal mucosa
    J Lindbom
    Dept of Health and Environment, Faculty of Health Sciences, University of Linkoping, Sweden
    Eur Respir J 18:130-8. 2001
    ..IVA, IVB, IVC, V, VI, VII, X, acid calcium-independent (aiPLA2), and calcium-independent membrane bound PLA2, (iPLA2-2)) in the nasal mucosa of five healthy human subjects...
  84. ncbi Human neutrophil migration in vitro induced by secretory phospholipases A2: a role for cell surface glycosaminoglycans
    Alessandra Gambero
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, PO Box 6111, 13081 970, Campinas, SP, Brazil
    Biochem Pharmacol 63:65-72. 2002
    ..Piratoxin-I, bothropstoxin-I, N. m. mocambique venom PLA2 (10-1000 microg/mL each), bothropstoxin-II (30-1000 microg/mL), porcine pancreas PLA2 (0.3-30 microg/mL), and A...
  85. ncbi Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:33866-77. 2003
    Previous studies suggested a role for calcium in CYP2E1-dependent toxicity. The possible role of phospholipase A2 (PLA2) activation in this toxicity was investigated...
  86. ncbi Prostaglandin release from lumbar disc and facet joint tissue
    R E Willburger
    Department of Orthopaedic Surgery, Ruhr University, Bochum, Germany
    Spine (Phila Pa 1976) 19:2068-70. 1994
    ..SUMMARY OF BACKGROUND DATA. High levels of phospholipase A2 (PLA2) have been measured in the human disc. PLA2 releases fatty acids from lipid membranes...
  87. ncbi An update on inhibitors of human 14 kDa Type II s-PLA2 in development
    D M Springer
    Anti infective Chemistry, Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, P O Box 5100, Wallingford, CT 06492, USA
    Curr Pharm Des 7:181-98. 2001
    Recent progress in the development of inhibitors of human Type II s-PLA2 as potential anti-inflammatory agents is presented...
  88. doi [Effect of magnesium isoglycyrrhizinate on PLA2 during liver tissue injury following limb ischemia/reperfusion in rats]
    Jin Chi Zhang
    Department of Vascular Surgery, the First Affiliated Hospial of Fujian Medical University, Fuzhou, China
    Zhonghua Gan Zang Bing Za Zhi 20:537-41. 2012
    To investigate the effects of magnesium isoglycyrrhizinate (MI) on the changes of phospholipase A2 (PLA2) induced during liver tissue injury following limb ischemia/reperfusion (I/R) in rats.
  89. doi Specific roles for Group V secretory PLA₂ in retinal iron-induced oxidative stress. Implications for age-related macular degeneration
    G Rodriguez Diez
    Instituto de Investigaciones Bioquimicas de Bahia Blanca, Universidad Nacional del Sur and Consejo Nacional de Investigaciones Cientificas y Tecnicas, 8000 Bahia Blanca, Argentina
    Exp Eye Res 113:172-81. 2013
    ..we have previously characterized the role of cytosolic phospholipase A2 (cPLA2) and calcium-independent isoform (iPLA2)...
  90. pmc Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry
    Yuan Hao Hsu
    Department of Chemistry, Tunghai University, Taichung, Taiwan
    PLoS ONE 8:e59267. 2013
    ..activity toward various cardiolipin forms and demonstrate that cardiolipin is a substrate for sPLA2, cPLA2 and iPLA2, but not for Lp-PLA2...
  91. pmc Effect of repetitive daily ethanol intoxication on adult rat brain: significant changes in phospholipase A2 enzyme levels in association with increased PARP-1 indicate neuroinflammatory pathway activation
    Nuzhath F Tajuddin
    Department of Molecular Pharmacology and Therapeutics, Stritch School of Medicine, Loyola University Chicago, 2160 S First Avenue, Maywood, IL 60153, USA
    Alcohol 47:39-45. 2013
    ..PARP (c-PARP), and caspase-3 levels were significantly elevated over controls, whereas Ca(+2)-independent PLA2 (iPLA2 VIA) was reduced ∼70%; however, cleaved caspase-3 was undetectable...
  92. ncbi Effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity in Japanese dyslipidemic patients, with exploratory analysis of a PLA2G7 gene polymorphism of Val279Phe
    Hiroyuki Daida
    Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Circ J 77:1518-25. 2013
    Lipoprotein-associated phospholipase A2 (Lp-PLA2) is being evaluated as a therapeutic target for treatment of atherosclerosis...
  93. ncbi Amelioration of atherosclerosis in apolipoprotein E-deficient mice by inhibition of lipoprotein-associated phospholipase A2
    Hui Zhang
    Department of Cardiology, the First Afliated Hospital of Zhengzhou University, Henan, China
    Clin Invest Med 36:E32-41. 2013
    ..In the present study, the abilities of darapladib, a selective Lp-PLA(2) inhibitor, and lentivirus-mediated Lp-PLA(2) silencing on inflammation and atherosclerosis in apolipoprotein E-deficient mice were compared...
  94. ncbi Regulation of group VIA phospholipase A2 expression by sterol availability
    Sarah J Seashols
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, VCU, Box 980614, Richmond, VA 23298 0614, USA
    Biochim Biophys Acta 1684:29-37. 2004
    ..of CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) and the group VIA calcium-independent phospholipase A2 (iPLA2)...
  95. pmc Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations
    Coro Paisan-Ruiz
    Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK
    Neurobiol Aging 33:814-23. 2012
    ..PKAN) and NBIA2 or infantile neuroaxonal dystrophy (INAD) due to mutations in the phospholipase A2, group VI (PLA2G6) gene...
  96. pmc Involvement of secretory phospholipase A2 activity in the zymosan rat air pouch model of inflammation
    M Paya
    Departamento de Farmacologia, Universidad de Valencia, Facultad de Farmacia, Spain
    Br J Pharmacol 117:1773-9. 1996
    1. In the zymosan rat air pouch model of inflammation we have assessed the time dependence of phospholipase A2 (PLA2) accumulation in the inflammatory exudates as well as cell migration, myeloperoxidase activity, prostaglandin E2 (PGE2) ..
  97. doi MVL-PLA2, a phospholipase A2 from Macrovipera lebetina transmediterranea venom, inhibits tumor cells adhesion and migration
    Amine Bazaa
    Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, 13 Place Pasteur Belvedère BP74, Tunis, Tunisia
    Matrix Biol 28:188-93. 2009
    Here, we report the purification and characterization of an acidic Asp49 phospholipase A2, named MVL-PLA2, with a molecular mass of 13,626.64 Da...
  98. ncbi Cellular and topical in vivo inflammatory murine models in the evaluation of inhibitors of phospholipase A2
    K B Glaser
    Inflammatory Diseases, Wyeth Ayerst Research, Princeton, N J, USA
    Skin Pharmacol 8:300-8. 1995
    Several novel inhibitors of human synovial fluid phospholipase A2 (HSF-PLA2) were evaluated in cellular models of inflammatory mediator release (murine macrophage and human neutrophil) and topical in vivo inflammatory skin models in mice ..
  99. ncbi Human group II phospholipase A2 in normal and diseased intervertebral discs
    K Miyahara
    Department of Orthopaedic Surgery, Shiga University of Medical Science, Japan
    Biochim Biophys Acta 1316:183-90. 1996
    We measured calcium-dependent phospholipase A2 (PLA2) activity and immunoreactive group II PLA2 levels of 54 normal discs obtained from cadavers and 73 disc samples surgically obtained from patients with spinal disorders, including ..
  100. pmc Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta
    Sasanka Ramanadham
    Mass Spectrometry Resource, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Washington University School of Medicine, Box 8127, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Biochemistry 43:918-30. 2004
    ..These findings indicate that iPLA(2)beta participates in ER stress-induced apoptosis, a pathway that promotes beta-cell death in diabetes...
  101. doi Phospholipase A2 activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease
    Evelin L Schaeffer
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, SP, Brazil
    Psychopharmacology (Berl) 202:37-51. 2009
    ..Evidence suggests that reduced activity of specific subtypes of intracellular phospholipases A2 (cPLA2 and iPLA2) is an early event in AD and may contribute to memory impairment and neuropathology in the disease.

Research Grants87

  1. CYTOSOLIC PHOSPHOLIPASE A2 TRANSFORMED CELLS
    Raphael Nemenoff; Fiscal Year: 2002
    ..Phospholipase A2 (PLA2), which hydrolyzes the sn-2 bond of membrane phospholipids, is the enzyme controlling arachidonic acid release...
  2. PHYSIOLOGIC/PATHOPHYSIOLOGIC REGULATION OF PHOSPHOLIPIDS
    Raphael Nemenoff; Fiscal Year: 1993
    ..Phospholipase A2 (PLA2), which hydrolyzes the sn-2 bond of membrane phospholipids, is the enzyme controlling arachidonic acid release...
  3. LIPID MEDIATORS OF SIGNAL TRANSDUCTION IN SMOOTH MUSCLE
    Richard Gross; Fiscal Year: 2000
    ..Collectively, these studies constitute a multidisciplinary approach aimed at elucidating the molecular mechanisms through which calcium-independent phospholipase A2 modulates vascular contractility and responsiveness. ..
  4. Amyloid Induced Proinflam. Pathways /Cerebrovasculature
    Michael Mullan; Fiscal Year: 2003
    ..a pro-inflammatory pathway (sPLA2-MAPK-cPLA2-AA-LOX/COX) involving activation of secretory phospholipase A2 (PLA2), mitogen-activated protein kinase (MAPK) kinase (MEKI/2), p38 MAPK, cytosolic PLA2 (cPLA2), and the release of ..
  5. GLYCEROLIPIDS & PROSTAGLANDIN SYNTHESIS IN EYE TISSUES
    ATA ABDEL LATIF; Fiscal Year: 1993
    ..The central hypothesis to be tested is that phospholipase A2 (PLA2) activation is a major source for AA release in the ICB...
  6. GLYCEROLIPIDS AND PROSTAGLANDIN BIOSYNTHESIS
    ATA ABDEL LATIF; Fiscal Year: 2001
    ..The central hypothesis to be tested is that phospholipase A2 (PLA2) activation is a major source for AA release in the ICB...
  7. Regulation and Function of Cytosolic Phospholipases A2 in Lung Cells
    CHRISTINA CARROLL LESLIE; Fiscal Year: 2010
    ..cPLA2? was identified as the PLA2 responsible for calcium-induced fatty acid release and prostaglandin E2 production in lung fibroblasts isolated ..
  8. Secretory Phospholipase A2s in Airway Pathophysiology
    Teal S Hallstrand; Fiscal Year: 2010
    ..The phospholipase A2s (PLA2)s are a group of enzymes that catalyze the rate-limiting step of AA release from membrane phospholipids initiating ..
  9. Regulation of Lipid Mediators in Spinal Microglia and Astrocytes
    Edward A Dennis; Fiscal Year: 2010
    ..Many of these lipids are derived from the reaction catalyzed by phospholipase A2 (PLA2)...
  10. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2001
    ..Site-specific spin labeling of the PLA2 from bee venom and EPR spectroscopy will be used to precisely map the surface of this enzyme that contacts the ..
  11. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Our preliminary results show that CDP-choline affects activation of membrane and mitochondrial phospholipase A2 (PLA2) that is raM-Ca 2+ dependent (characteristic of secretory PLA2; sPLA2), supporting the hypothesis and Aim 1...
  12. Calcium-Independent PLA2Beta in Beta-Cell Apoptosis
    Sasanka Ramanadham; Fiscal Year: 2010
    ..Our hypothesis in the 1st project period (10/04-7/09) was that the group VIA Ca2+-independent phospholipase A2 (iPLA2) participates in ER stress-induced -cell apoptosis...
  13. Pharmacogenetic Antiplatelet Strategies in CHD Patients
    Glen Cooke; Fiscal Year: 2007
    ..The GPIlb-IIIa receptor is known to be polymorphic and the presence of the PLA2 allele has been associated with an increased prevalence of ischemic syndromes, especially in younger individuals...
  14. Studies of Eicosanoid Biosynthetic Proteins
    Wonhwa Cho; Fiscal Year: 2010
    Arachidonic acid (AA), which is liberated from membrane phospholipids by phospholipase A2 (PLA2), is converted to oxidized lipids collectively known as eicosanoids, including prostaglandins and leukotrienes (LT), through the ..
  15. Regulation of Vascular Smooth Muscle Contracting
    Ming Gong; Fiscal Year: 2005
    ..We propose to test the hypothesis that AA, released by ras-mediated activation of Ca2+-independent iPLA2, contributes to the agonist-induced Ca2+-sensitization by acting at multiple sites: rho-kinase (ROK)...