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Genomes and Genes
| PLA2G5SummaryGene Symbol: PLA2G5 Description: phospholipase A2, group V Alias: FRFB, GV-PLA2, PLA2-10, hVPLA(2), Ca2+-dependent phospholipase A2, calcium-dependent phospholipase A2, phosphatidylcholine 2-acylhydrolase 5 Species: human Top Publications
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Detail Information
Publications
Biallelic mutations in PLA2G5, encoding group V phospholipase A2, cause benign fleck retinaPanagiotis I Sergouniotis
Institute of Ophthalmology, University College London, London, UK
Am J Hum Genet 89:782-91. 2011..133G>T (p.Gly45Cys), in PLA2G5, a gene encoding a secreted phospholipase (group V phospholipase A(2))...- Group V secretory phospholipase A2 amplifies the induction of cyclooxygenase 2 and delayed prostaglandin D2 generation in mouse bone marrow culture-derived mast cells in a strain-dependent mannerBruno L Diaz
Department of Medicine Harvard Medical School and the Division of Rheumatology Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
Biochim Biophys Acta 1761:1489-97. 2006..We used mice lacking the gene encoding group V sPLA(2) (Pla2g5-/-) to definitively test its role in eicosanoid generation by BMMC... 
Inflammation and atherosclerosis: Group IIa and Group V sPLA2 are not redundantFrederick C de Beer
Arterioscler Thromb Vasc Biol 26:1421-2. 2006- Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophilsNilda M Munoz
Section of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
J Immunol 177:574-82. 2006..We also demonstrate that gVPLA(2), endogenously secreted from activated epithelial cells, promotes secretion of LTC(4) in cocultured eosinophils... - Secretory phospholipase A2 group V: lesion distribution, activation by arterial proteoglycans, and induction in aorta by a Western dietBirgitta Rosengren
AstraZeneca, R and D, Molecular Pharmacology, Mölndal S 431 83, Sweden
Arterioscler Thromb Vasc Biol 26:1579-85. 2006..In addition, we also investigated the effect of a Western diet and lipopolysaccharide challenge on the aortic expression of these enzymes in mouse models... - Systematic evaluation of transcellular activities of secretory phospholipases A2. High activity of group V phospholipases A2 to induce eicosanoid biosynthesis in neighboring inflammatory cellsGihani T Wijewickrama
Department of Chemistry, University of Illinois, Chicago, Illinois 60607, USA
J Biol Chem 281:10935-44. 2006.... - Effects of Crotalus durissus collilineatus venom in the isolated rat kidneyDaniela N Amora
Department of Physiology and Pharmacology, Institute of Biomedicine and Clinical Research Unit, Federal University of Ceara, Fortaleza, Ceara, Brazil
Toxicon 47:260-4. 2006..We suggest that crotoxin and phospholipase A2 were involved in this process, since the renal effects observed would be due to the synergistic action of the components of the venom... - PGE2 release is independent of upregulation of Group V phospholipase A2 during long-term stimulation of P388D1 cells with LPSUrsula A Kessen
Department of Chemistry, University of California San Diego, La Jolla, CA 92093, USA
J Lipid Res 46:2488-96. 2005..LPS stimulation also results in increased expression and secretion of a secretory PLA2, specifically GV PLA2. To test whether GV PLA2 contributes to PGE2 production and whether GIVA PLA2 activation increases the expression .. - Group V and X secretory phospholipase A2 prevents adenoviral infection in mammalian cellsMichiko Mitsuishi
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
Biochem J 393:97-106. 2006.... - Expression of type V secretory phospholipase A in myocardial remodelling after infarctionY Ishikawa
Department of Pathology, School of Dentistry, Nihon University, Tokyo, Japan
Histopathology 47:257-67. 2005..The significance of sPLA2-V in myocardial infarction was investigated histopathologically... - Group V secretory phospholipase A2-modified low density lipoprotein promotes foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycansBoris B Boyanovsky
Department of Internal Medicine and Veterans Affairs Medical Center, Graduate Center for Nutritional Sciences, University of Kentucky Medical Center, Lexington, Kentucky 40536 0200, USA
J Biol Chem 280:32746-52. 2005..Our data point to a physiological modification of LDL that has the potential to promote macrophage foam cell formation independent of scavenger receptors... - Tetrandrine and thapsigargin release arachidonic acid from cells in culture and stimulate prostacyclin production in rat liver cells, but may do so by different pathwaysLawrence Levine
Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA
BMC Pharmacol 5:12. 2005..The effects of tetrandrine and thapsigargin on arachidonic acid release from human colon carcinoma and rat liver cells and prostacyclin production by rat liver cells are compared in the current studies... - Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS studyPeter T E Wootton
Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, 5 University Street, London WC1E 6JF, UK
Hum Mol Genet 16:1437-44. 2007..human studies suggest that both secretory PLA2 (sPLA2)-V and sPLA2-IIA (encoded, respectively, by the neighbouring PLA2G5 and PLA2G2A genes) contribute to atherogenesis... - Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized miceNilda M Munoz
Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
J Immunol 179:4800-7. 2007..Blockade of bronchoconstriction by MCL-3G1 was replicated in allergic pla2g5-/- mice, which lack the gene encoding gVPLA2... - Blood-cerebrospinal fluid barrier permeability in Alzheimer's diseaseSonia Chalbot
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, NY 10314 6399, USA
J Alzheimers Dis 25:505-15. 2011..These results suggest that the BCB damage occurs independent of and probably precedes both Aβ and tau pathologies in a restricted subgroup of AD patients... - Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell functionGiorgio Giannattasio
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
J Immunol 185:4430-8. 2010..In this study, we report that group V sPLA(2) (Pla2g5)-null mice exposed to an extract of house dust mite Dermatophagoides farinae had markedly reduced pulmonary .. - Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity: a biomarker of blood-cerebrospinal fluid barrier permeabilitySonia Chalbot
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314 6399, USA
Neurosci Lett 478:179-83. 2010..Though the CSF sPLA2 activity and Q(Alb) had over 95% agreement, the former was found to be more sensitive than the latter in measuring low levels of BCB impairment... - Group V phospholipase A2 mediates barrier disruption of human pulmonary endothelial cells caused by LPS in vitroSteven M Dudek
Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, IL 60637, USA
Am J Respir Cell Mol Biol 44:361-8. 2011.... 
High-resolution transcriptional profiling of chemical-stimulated dendritic cells identifies immunogenic contact allergens, but not prohaptensH Ott
Department of Dermatology and Allergology, RWTH Aachen University Hospital, Aachen, Germany hagen ott post rwth aachen de
Skin Pharmacol Physiol 23:213-24. 2010..revealed coregulation of 11 marker genes which were related to immunological reactions (IL-8, CD1e, CD200R1, PLA2G5, TNFRSF11A), oxidative or metabolic stress responses (AKR1C3, SLC7A11, GCLM) or other processes (DPYLS3, TFPI, ..- Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in IndiaIndranil Chattopadhyay
Institute of Pathology, New Delhi 110029, India
Mutat Res 696:130-8. 2010..The candidate genes located at amplified regions of chromosomes or low-level gain regions such as PLA2G5 (1p36-p34), COL11A1 (1p21), KCNK2 (1q41), S100A3 (1q21), ENAH (1q42... - Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer diseaseSonia Chalbot
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314 6399, USA
Clin Chem 55:2171-9. 2009.... - Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in miceNilda M Munoz
Dept of Medicine, M6076, Univ of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
Am J Physiol Lung Cell Mol Physiol 296:L879-87. 2009..Experiments were conducted in gVPLA(2) knockout (pla2g5(-/-)) mice, which lack the gene, and gVPLA(2) wild-type littermate control (pla2g5(+/+)) mice... - Altered eicosanoid metabolism in the cystic fibrosis mouse small intestineRobert C De Lisle
Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
J Pediatr Gastroenterol Nutr 47:406-16. 2008..Imbalances in essential fatty acid levels have been reported in cystic fibrosis (CF), which may relate to elevated proinflammatory eicosanoid generation. The aim of this work was to better define eicosanoid metabolism in the CF intestine... - Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosisHiroyasu Sato
Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
J Biol Chem 283:33483-97. 2008..showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E... - Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidateC M Mounier
Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UNSA UMR6097, Sophia Antipolis, Valbonne, France
Br J Cancer 98:587-95. 2008..In normal colon, PLA2G2A and PLA2G12A were expressed at high levels, PLA2G2D, PLA2G5, PLA2G10 and PLA2G12B at moderate levels, and PLA2G1B, PLA2G2F and PLA2G3 at low levels... - Angiotensin II-induced Akt activation is mediated by metabolites of arachidonic acid generated by CaMKII-stimulated Ca2(+)-dependent phospholipase A2Fang Li
Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Am J Physiol Heart Circ Physiol 288:H2306-16. 2005.... - Prostaglandin E2 and microsomal prostaglandin E synthase-2 expression are decreased in the cyclooxygenase-2-deficient mouse brain despite compensatory induction of cyclooxygenase-1 and Ca2+-dependent phospholipase A2Francesca Bosetti
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurochem 91:1389-97. 2004..Overall, the data suggest that compensatory mechanisms exist in COX-2(-/-) mice and that mPGES-2 is functionally coupled with COX-2... - Cytosolic phospholipase A2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid-beta peptideBadreddine Kriem
INSERM EMI 0014, Universite de Nancy I, Vandoeuvre, France
FASEB J 19:85-7. 2005..This may prove to be crucial in AD processes and could provide important targets for drug development... - The molecular basis of phosphatidylcholine preference of human group-V phospholipase A2K P Kim
Department of Chemistry M C 111, University of Illinois at Chicago, 845 West Taylor Street, Chicago, IL 60607 7061, USA
Biochem J 348:643-7. 2000.... - Expression of cytosolic and secreted forms of phospholipase A(2) and cyclooxygenases in human placenta, fetal membranes, and chorionic cell linesB Johansen
UNIGEN Center for Molecular Biology, Department of Botany, Norwegian University of Science and Technology, N 7489, Trondheim, Norway
Prostaglandins Other Lipid Mediat 60:119-25. 2000..These results suggest that both cytosolic and distinct secreted forms of PLA(2) could be involved in arachidonic acid (AA) release preceding prostaglandin production at the fetal/maternal interface... - Low molecular weight group IIA and group V phospholipase A(2) enzymes have different intracellular locations in mouse bone marrow-derived mast cellsC O Bingham
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 274:31476-84. 1999..The spatial segregation of group IIA PLA(2) and group V PLA(2) implies that these enzymes are not functionally redundant... - Characterization of Ca2+-dependent phospholipase A2 activity during zebrafish embryogenesisS A Farber
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
J Biol Chem 274:19338-46. 1999..Biol. Chem. 269, 18239-18249). By using a quenched BODIPY-labeled phosphatidylcholine that fluoresces only upon cleavage by PLA2, lipase activity was visualized in the cells of living embryos where it localized to perinuclear membranes... - Large-scale sequencing of the rabbit corneal endothelial cDNA libraryT Fujimaki
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
Cornea 18:109-14. 1999..This study sought to identify novel or active genes in corneal endothelial cells with description of the gene-expression profile... - Expression and characterization of human group V phospholipase A2Y Chen
Department of Chemistry and Biochemistry, School of Medicine and Revelle College, University of California, San Diego, La Jolla, CA 92093 0601, USA
Biochim Biophys Acta 1394:57-64. 1998.... - Cloning and expression of a group IV cytosolic Ca2+-dependent phospholipase A2 from rat pancreatic islets. Comparison of the expressed activity with that of an islet group VI cytosolic Ca2+-independent phospholipase A2Z Ma
Mass Spectrometry Resource, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Biochim Biophys Acta 1391:384-400. 1998..The cPLA2 is thus one of at least three classes of PLA2 enzymes with distinct properties expressed in beta-cells... - HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytesE Mavoungou
Department of Immunology and Immunogenetics, International Center for Medical Research, Franceville, Gabon
J Acquir Immune Defic Syndr Hum Retrovirol 16:1-9. 1997..However, this effect is not sufficient to accomplish fusion. These data indicate that the specific step of fusion may be downstream from PLA2 activation... - Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and humanJ A Tischfield
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202 5251, USA
Genomics 32:328-33. 1996..Unlike its rodent counterpart, human PLA2G2C appears to be a nonfunctional pseudogene... - Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2J Chen
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202
J Biol Chem 269:2365-8. 1994.... - Oligomers of prostaglandin B1 inhibit in vitro phospholipase A2 activityR C Franson
Department of Biochemistry and Molecular Biophysics, Virginia Commonwealth University, Richmond 23298
Biochim Biophys Acta 1006:272-7. 1989.... - Cell-specific expression of group X and group V secretory phospholipases A(2) in human lung airway epithelial cellsM C Seeds
Departments of Internal Medicine Section on Pulmonary and Critical Care, Pathology, and Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Am J Respir Cell Mol Biol 23:37-44. 2000.... - Structure, function, and regulation of group V phospholipase A(2)W Cho
Department of Chemistry M C 111, University of Illinois at Chicago, 60607 7061, USA
Biochim Biophys Acta 1488:48-58. 2000..Finally, heparan sulfate proteoglycans in neutrophils appear to play a role of internalizing and degrading the cell surface-bound gVPLA(2) to protect the cells from extensive lipolytic damage... - Distribution of type V secretory phospholipase A2 expression in human hepatocytes damaged by liver diseaseMasamichi Ito
Department of Pathology, Toho University School of Medicine, Tokyo, Japan
J Gastroenterol Hepatol 19:1140-9. 2004..However, the distribution of sPLA2-V in human liver has not yet been investigated. In this study, the significance of sPLA2-V expression in human hepatocytes damaged by liver disease was investigated... - Presence of secretory group IIa and V phospholipase A2 and cytosolic group IValpha phospholipase A2 in chondrocytes from patients with rheumatoid arthritisLilian Leistad
Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Clin Chem Lab Med 42:602-10. 2004..These results suggest that each phospholipase A2 enzyme has distinct roles in both healthy and diseased joint tissue, and that the diversity and amount of enzyme correlate with the grade of inflammation and disease severity... - Localization of group V phospholipase A2 in caveolin-enriched granules in activated P388D1 macrophage-like cellsMaría A Balboa
Department of Chemistry and Biochemistry, School of Medicine, University of California at San Diego, La Jolla, California 92093 0601, USA
J Biol Chem 278:48059-65. 2003.... - Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophilsNilda M Munoz
Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 278:38813-20. 2003..As such, this study represents a unique example in which a secretory phospholipase induces the eicosanoid formation in inflammatory cells, completely independent of cPLA2 activation... - Role of three isoforms of phospholipase A2 in capacitative calcium influx in human T-cellsAziz Hichami
UPRES Lipides and Nutrition, Université de Bourgogne 21000 Dijon, France Central Jalma Research Institute for Leprosy, Agra, UP, India
Eur J Biochem 269:5557-63. 2002..These results suggest that stimulation of three isoforms of PLA2 by thapsigargin liberates free AA that, in turn, induces capacitative calcium influx in human T-cells... - Essential role of Ca2+ -dependent phospholipase A2 in estradiol-induced lysosome activationBruno Burlando
Dipartimento di Scienze e Tecnologie Avanzate, Universita del Piemonte Orientale Amedeo Avogadro, 15100 Alessandria, Biologia e Genetica, Universita di Genova, 16132 Genoa, Italy
Am J Physiol Cell Physiol 283:C1461-8. 2002..This mechanism promotes lysosome fusion and catabolic activities and may mediate short-term estradiol effects... - Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group IVA phospholipase A2Young Jun Kim
Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607, USA
J Biol Chem 277:36479-88. 2002.... - Purification and characterization of a cytosolic, 42-kDa and Ca2+-dependent phospholipase A2 from bovine red blood cells: its involvement in Ca2+-dependent release of arachidonic acid from mammalian red blood cellsHae Sook Shin
Department of Environmental and Health Chemistry, College of Pharmacy, Chung Ang University, Dongjak Ku, Seoul 156 756, South Korea
J Biol Chem 277:21086-94. 2002..Together, our results suggest that the 42-kDa rPLA(2) identified as a novel form of Ca(2+)-dependent PLA(2) may play an important role in hemostasis, thrombosis, and/or erythropoiesis through the Ca(2+)-dependent release of AA... - Human neutrophil migration in vitro induced by secretory phospholipases A2: a role for cell surface glycosaminoglycansAlessandra Gambero
Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, PO Box 6111, 13081 970, Campinas, SP, Brazil
Biochem Pharmacol 63:65-72. 2002..Our results suggest that neutrophil migration in response to sPLA2s is independent of PLA activity, and involves an interaction of sPLA2s with cell surface heparin/heparan binding sites triggering the release of LTB4 and PAF... - Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysisNorbert Degousee
Division of Vascular Surgery, Max Bell Research Center, Toronto General Hospital, University Health Network, Toronto M5G 2C4, Canada
J Biol Chem 277:5061-73. 2002.... - VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2P N Bernatchez
Research Center, Montreal Heart Institute, Montreal QC, Canada
Br J Pharmacol 134:197-205. 2001..7. These results provide evidence that with VEGF activation of EC cells, the group V sPLA2 provides substrate for EC PAF formation... - Fusion of neurotransmitter vesicles with target membrane is calcium independent in a cell-free systemU O Karli
Friedrich Miescher Institut, Basel, Switzerland
Proc Natl Acad Sci U S A 87:5912-5. 1990....
Research Grants
- EHRLICHIACIDAL MECHANISM BY MACROPHAGE CA++ MOBILIZATIONYasuko Rikihisa; Fiscal Year: 1992....
- Beta-Adrenergic Receptor Function in Atrial MyocytesSTEPHEN LIPSIUS; Fiscal Year: 2007..abstract_text> ..
- Regulation of Prostaglandin Production in MacrophagesEDWARD DENNIS; Fiscal Year: 2005..We will also explore how the extracellular GV PLA2 is controlled, i.e. via up-regulation, subcellular translocation, or activation...
- Membrane Targeting by Phosphoinositide-Binding ProteinsWonhwa Cho; Fiscal Year: 2010....
- Membrane Targeting by Phosphoinositide-Binding ProteinsWonhwa Cho; Fiscal Year: 2010....
- Structure Function Studies Of Membrane Binding ProteinsWonhwa Cho; Fiscal Year: 2004....
- Studies of Eicosanoid Biosynthetic ProteinsWonhwa Cho; Fiscal Year: 2010..This timely and critical information will accelerate development and evaluation of new therapeutic agents for inflammatory diseases, cardiovascular diseases, and cancer. ..
- Studies of Diacylglycerol-Binding ProteinsWonhwa Cho; Fiscal Year: 2009....
- Membrane Targeting by Phosphoinositide Binding ProteinsWonhwa Cho; Fiscal Year: 2006....
- Studies of Diacylglycerol-Binding ProteinsWonhwa Cho; Fiscal Year: 2007....
- MECHANISM OF PHOSPHOLIPASE A2 REGULATIONWonhwa Cho; Fiscal Year: 2007....
- MECHANISM OF PHOSPHOLIPASE A2 REGULATIONWonhwa Cho; Fiscal Year: 2003..abstract_text> ..
- STRUCTURE/FUNCTION STUDIES OF MEMBRANE BINDING PROTEINSWonhwa Cho; Fiscal Year: 2000....
- MECHANISM OF PHOSPHOLIPASE A2 REGULATIONWonhwa Cho; Fiscal Year: 1999....
- PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEMROBERT DE LISLE; Fiscal Year: 2003..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
- TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTIONROBERT DE LISLE; Fiscal Year: 2003..That over expresses Muclin in the pancreatic acinar cell using the rat elastase promoter to direct cell specific expression. ..