PLA2G2E

Summary

Gene Symbol: PLA2G2E
Description: phospholipase A2, group IIE
Alias: GIIE sPLA2, sPLA2-IIE, group IIE secretory phospholipase A2, phosphatidylcholine 2-acylhydrolase 2E
Species: human

Top Publications

  1. ncbi Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s
    N Suzuki
    Shionogi Research Laboratories, Shionogi and Company, Limited, Sagisu 5 12 4, Fukushima ku, Osaka 553 0002, Japan
    J Biol Chem 275:5785-93. 2000
  2. ncbi Arachidonate release and eicosanoid generation by group IIE phospholipase A(2)
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 292:689-96. 2002
  3. pmc Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Nat Genet 42:332-7. 2010
  4. doi Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians
    Suk Kyun Yang
    Department of Gastroenterology, Asan Medical Center, Seoul, South Korea
    Inflamm Bowel Dis 19:954-66. 2013
  5. ncbi HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes
    E Mavoungou
    Department of Immunology and Immunogenetics, International Center for Medical Research, Franceville, Gabon
    J Acquir Immune Defic Syndr Hum Retrovirol 16:1-9. 1997
  6. pmc Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis
    Hiroyasu Sato
    Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
    J Biol Chem 283:33483-97. 2008
  7. pmc Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009

Scientific Experts

  • Dermot P B McGovern
  • Makoto Murakami
  • E Mavoungou
  • Suk Kyun Yang
  • Mark S Silverberg
  • Hiroyasu Sato
  • Inchul Lee
  • Hyoung Doo Shin
  • Sung Ae Jung
  • Sang Hyoung Park
  • Hyo Jong Kim
  • Kyung Jo Kim
  • Kyuyoung Song
  • Hyun Sub Cheong
  • Jianjun Liu
  • Naeimeh Tayebi
  • Wanting Zhao
  • Yusun Jung
  • Hee Shang Youn
  • Byong Duk Ye
  • Myunghee Hong
  • Lyoung Hyo Kim
  • Daehee Kang
  • N Suzuki
  • Kent D Taylor
  • Regan Scott
  • Vito Annese
  • Lambertus Klei
  • Andrew F Ippoliti
  • A Hillary Steinhart
  • Miguel D Regueiro
  • M Michael Barmada
  • Mark J Daly
  • Fabrizio Bossa
  • Judy H Cho
  • Clara Abraham
  • Jean Paul Achkar
  • Stephan R Targan
  • Steven R Brant
  • Jerome I Rotter
  • Anne M Griffiths
  • Kathryn Roeder
  • Annette T Lee
  • Raymond G Lahaie
  • Emily O Kistner
  • Theodore M Bayless
  • Jing Wu
  • John D Rioux
  • L Philip Schumm
  • Wei Xu
  • Deborah D Proctor
  • Richard H Duerr
  • Philippe Goyette
  • Pierre Pare
  • Peter K Gregersen
  • Anna Latiano
  • Toshiharu Ishii
  • Hiroyuki Itabe
  • Rina Kato
  • Shinji Hatakeyama
  • Joe Yamada
  • Seiko Masuda
  • Ichiro Kudo
  • Ryo Taguchi
  • Yukio Ishikawa
  • Tetsuyuki Kobayashi
  • Go ichi Saka
  • Yuki Isogai
  • Mitsuhiro Ohtsuki
  • Kazutaka Ikeda
  • Kei Yamamoto
  • Shuntaro Hara
  • Kae Tsutsumi
  • Yoshitaka Taketomi
  • Y Yokota
  • J Ishizaki
  • K Kawamoto
  • M Ikeda
  • K Hanasaki
  • T Ono
  • N Fujii
  • K Higashino

Detail Information

Publications8

  1. ncbi Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s
    N Suzuki
    Shionogi Research Laboratories, Shionogi and Company, Limited, Sagisu 5 12 4, Fukushima ku, Osaka 553 0002, Japan
    J Biol Chem 275:5785-93. 2000
    ..These findings suggest a distinct functional role of novel sPLA(2)-IIE in the progression of inflammatory processes...
  2. ncbi Arachidonate release and eicosanoid generation by group IIE phospholipase A(2)
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 292:689-96. 2002
    ..These observations suggest that this enzyme plays a role in the inflammatory process, as proposed for other group II subfamily sPLA(2)s...
  3. pmc Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Nat Genet 42:332-7. 2010
    ..These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis...
  4. doi Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians
    Suk Kyun Yang
    Department of Gastroenterology, Asan Medical Center, Seoul, South Korea
    Inflamm Bowel Dis 19:954-66. 2013
    ..We performed a genome-wide association studies to identify UC susceptibility loci in a Korean population and further comparative study...
  5. ncbi HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes
    E Mavoungou
    Department of Immunology and Immunogenetics, International Center for Medical Research, Franceville, Gabon
    J Acquir Immune Defic Syndr Hum Retrovirol 16:1-9. 1997
    ..However, this effect is not sufficient to accomplish fusion. These data indicate that the specific step of fusion may be downstream from PLA2 activation...
  6. pmc Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis
    Hiroyasu Sato
    Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
    J Biol Chem 283:33483-97. 2008
    ..by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E. PLA2G3-modified LDL, like PLA2G5- or PLA2G10-treated LDL, facilitated the formation of foam cells from ..
  7. pmc Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009
    ..0 x 10(-16), combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 x 10(-8), combined OR = 0.56; rs10889677, combined P = 1.3 x 10(-8), combined OR = 1.29)...