PLA2G2E

Summary

Gene Symbol: PLA2G2E
Description: phospholipase A2, group IIE
Alias: GIIE sPLA2, sPLA2-IIE, group IIE secretory phospholipase A2, phosphatidylcholine 2-acylhydrolase 2E
Species: human

Top Publications

  1. ncbi HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes
    E Mavoungou
    Department of Immunology and Immunogenetics, International Center for Medical Research, Franceville, Gabon
    J Acquir Immune Defic Syndr Hum Retrovirol 16:1-9. 1997
  2. ncbi Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s
    N Suzuki
    Shionogi Research Laboratories, Shionogi and Company, Limited, Sagisu 5 12 4, Fukushima ku, Osaka 553 0002, Japan
    J Biol Chem 275:5785-93. 2000
  3. ncbi Arachidonate release and eicosanoid generation by group IIE phospholipase A(2)
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 292:689-96. 2002
  4. ncbi Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis
    Hiroyasu Sato
    Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
    J Biol Chem 283:33483-97. 2008
  5. ncbi Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009

Scientific Experts

  • Makoto Murakami
  • E Mavoungou
  • Mark S Silverberg
  • Hiroyasu Sato
  • N Suzuki
  • Kent D Taylor
  • Miguel D Regueiro
  • Wei Xu
  • Lambertus Klei
  • Anne M Griffiths
  • Deborah D Proctor
  • Pierre Pare
  • Clara Abraham
  • Emily O Kistner
  • Theodore M Bayless
  • Annette T Lee
  • A Hillary Steinhart
  • Regan Scott
  • M Michael Barmada
  • Philippe Goyette
  • Judy H Cho
  • Steven R Brant
  • Vito Annese
  • Dermot P B McGovern
  • Jean Paul Achkar
  • Jerome I Rotter
  • John D Rioux
  • Kathryn Roeder
  • Andrew F Ippoliti
  • Peter K Gregersen
  • Raymond G Lahaie
  • L Philip Schumm
  • Richard H Duerr
  • Mark J Daly
  • Anna Latiano
  • Stephan R Targan
  • Jing Wu
  • Fabrizio Bossa
  • Kae Tsutsumi
  • Joe Yamada
  • Yukio Ishikawa
  • Yoshitaka Taketomi
  • Go ichi Saka
  • Shuntaro Hara
  • Mitsuhiro Ohtsuki
  • Shinji Hatakeyama
  • Yuki Isogai
  • Kazutaka Ikeda
  • Tetsuyuki Kobayashi
  • Ichiro Kudo
  • Seiko Masuda
  • Rina Kato
  • Kei Yamamoto
  • Ryo Taguchi
  • Hiroyuki Itabe
  • Toshiharu Ishii
  • N Fujii
  • K Higashino
  • J Ishizaki
  • K Hanasaki
  • Y Yokota
  • T Ono
  • K Kawamoto
  • M Ikeda

Detail Information

Publications6

  1. ncbi HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes
    E Mavoungou
    Department of Immunology and Immunogenetics, International Center for Medical Research, Franceville, Gabon
    J Acquir Immune Defic Syndr Hum Retrovirol 16:1-9. 1997
    ..However, this effect is not sufficient to accomplish fusion. These data indicate that the specific step of fusion may be downstream from PLA2 activation...
  2. ncbi Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s
    N Suzuki
    Shionogi Research Laboratories, Shionogi and Company, Limited, Sagisu 5 12 4, Fukushima ku, Osaka 553 0002, Japan
    J Biol Chem 275:5785-93. 2000
    ..These findings suggest a distinct functional role of novel sPLA(2)-IIE in the progression of inflammatory processes...
  3. ncbi Arachidonate release and eicosanoid generation by group IIE phospholipase A(2)
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 292:689-96. 2002
    ..These observations suggest that this enzyme plays a role in the inflammatory process, as proposed for other group II subfamily sPLA(2)s...
  4. ncbi Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis
    Hiroyasu Sato
    Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
    J Biol Chem 283:33483-97. 2008
    ..by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E. PLA2G3-modified LDL, like PLA2G5- or PLA2G10-treated LDL, facilitated the formation of foam cells from ..
  5. ncbi Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009
    ..0 x 10(-16), combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 x 10(-8), combined OR = 0.56; rs10889677, combined P = 1.3 x 10(-8), combined OR = 1.29)...