PLA2G2E

Summary

Gene Symbol: PLA2G2E
Description: phospholipase A2, group IIE
Alias: GIIE sPLA2, sPLA2-IIE, group IIE secretory phospholipase A2, phosphatidylcholine 2-acylhydrolase 2E
Species: human

Top Publications

  1. ncbi Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s
    N Suzuki
    Shionogi Research Laboratories, Shionogi and Company, Limited, Sagisu 5 12 4, Fukushima ku, Osaka 553 0002, Japan
    J Biol Chem 275:5785-93. 2000
  2. ncbi Arachidonate release and eicosanoid generation by group IIE phospholipase A(2)
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 292:689-96. 2002
  3. pmc Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Nat Genet 42:332-7. 2010
  4. doi Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians
    Suk Kyun Yang
    Department of Gastroenterology, Asan Medical Center, Seoul, South Korea
    Inflamm Bowel Dis 19:954-66. 2013
  5. ncbi HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes
    E Mavoungou
    Department of Immunology and Immunogenetics, International Center for Medical Research, Franceville, Gabon
    J Acquir Immune Defic Syndr Hum Retrovirol 16:1-9. 1997
  6. pmc Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis
    Hiroyasu Sato
    Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
    J Biol Chem 283:33483-97. 2008
  7. pmc Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009

Scientific Experts

  • Dermot P B McGovern
  • Makoto Murakami
  • E Mavoungou
  • Suk Kyun Yang
  • Mark S Silverberg
  • Hiroyasu Sato
  • Hee Shang Youn
  • Sung Ae Jung
  • Myunghee Hong
  • Kyung Jo Kim
  • Byong Duk Ye
  • Jianjun Liu
  • Inchul Lee
  • Kyuyoung Song
  • Wanting Zhao
  • Lyoung Hyo Kim
  • Yusun Jung
  • Naeimeh Tayebi
  • Hyo Jong Kim
  • Sang Hyoung Park
  • Hyoung Doo Shin
  • Daehee Kang
  • Hyun Sub Cheong
  • N Suzuki
  • Kent D Taylor
  • M Michael Barmada
  • Kathryn Roeder
  • Andrew F Ippoliti
  • Pierre Pare
  • Philippe Goyette
  • Clara Abraham
  • Judy H Cho
  • Emily O Kistner
  • Peter K Gregersen
  • Raymond G Lahaie
  • L Philip Schumm
  • Steven R Brant
  • Richard H Duerr
  • Miguel D Regueiro
  • Wei Xu
  • Lambertus Klei
  • Mark J Daly
  • Vito Annese
  • Anna Latiano
  • Theodore M Bayless
  • Annette T Lee
  • Anne M Griffiths
  • A Hillary Steinhart
  • Jean Paul Achkar
  • Jerome I Rotter
  • John D Rioux
  • Stephan R Targan
  • Regan Scott
  • Jing Wu
  • Fabrizio Bossa
  • Deborah D Proctor
  • Kazutaka Ikeda
  • Kae Tsutsumi
  • Ichiro Kudo
  • Go ichi Saka
  • Shuntaro Hara
  • Joe Yamada
  • Seiko Masuda
  • Yukio Ishikawa
  • Yoshitaka Taketomi
  • Mitsuhiro Ohtsuki
  • Rina Kato
  • Kei Yamamoto
  • Ryo Taguchi
  • Shinji Hatakeyama
  • Yuki Isogai
  • Hiroyuki Itabe
  • Toshiharu Ishii
  • Tetsuyuki Kobayashi
  • M Ikeda
  • J Ishizaki
  • K Hanasaki
  • N Fujii
  • Y Yokota
  • T Ono
  • K Kawamoto
  • K Higashino

Detail Information

Publications8

  1. ncbi Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s
    N Suzuki
    Shionogi Research Laboratories, Shionogi and Company, Limited, Sagisu 5 12 4, Fukushima ku, Osaka 553 0002, Japan
    J Biol Chem 275:5785-93. 2000
    ..These findings suggest a distinct functional role of novel sPLA(2)-IIE in the progression of inflammatory processes...
  2. ncbi Arachidonate release and eicosanoid generation by group IIE phospholipase A(2)
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 292:689-96. 2002
    ..These observations suggest that this enzyme plays a role in the inflammatory process, as proposed for other group II subfamily sPLA(2)s...
  3. pmc Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Nat Genet 42:332-7. 2010
    ..These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis...
  4. doi Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians
    Suk Kyun Yang
    Department of Gastroenterology, Asan Medical Center, Seoul, South Korea
    Inflamm Bowel Dis 19:954-66. 2013
    ..We performed a genome-wide association studies to identify UC susceptibility loci in a Korean population and further comparative study...
  5. ncbi HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes
    E Mavoungou
    Department of Immunology and Immunogenetics, International Center for Medical Research, Franceville, Gabon
    J Acquir Immune Defic Syndr Hum Retrovirol 16:1-9. 1997
    ..However, this effect is not sufficient to accomplish fusion. These data indicate that the specific step of fusion may be downstream from PLA2 activation...
  6. pmc Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis
    Hiroyasu Sato
    Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
    J Biol Chem 283:33483-97. 2008
    ..by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E. PLA2G3-modified LDL, like PLA2G5- or PLA2G10-treated LDL, facilitated the formation of foam cells from ..
  7. pmc Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009
    ..0 x 10(-16), combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 x 10(-8), combined OR = 0.56; rs10889677, combined P = 1.3 x 10(-8), combined OR = 1.29)...