PLA2G2D

Summary

Gene Symbol: PLA2G2D
Description: phospholipase A2, group IID
Alias: PLA2IID, SPLASH, sPLA2-IID, sPLA2S, GIID sPLA2, group IID secretory phospholipase A2, phosphatidylcholine 2-acylhydrolase 2D, secretory phospholipase A2s, secretory-type PLA, stroma-associated homolog
Species: human

Top Publications

  1. ncbi Camphor Poisoning: an evidence-based practice guideline for out-of-hospital management
    Anthony S Manoguerra
    American Association of Poison Control Centers, Washington, District of Columbia 20016, USA
    Clin Toxicol (Phila) 44:357-70. 2006
  2. ncbi Heavy metals in bark of Pinus massoniana (Lamb.) as an indicator of atmospheric deposition near a smeltery at Qujiang, China
    Yuan Wen Kuang
    South China Botanical Garden, The Chinese Academy of Sciences, Guangzhou 510650, China
    Environ Sci Pollut Res Int 14:270-5. 2007
  3. ncbi Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2)
    Rao S Koduri
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 277:5849-57. 2002
  4. doi Biochemistry and physiology of mammalian secreted phospholipases A2
    Gerard Lambeau
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Universite de Nice Sophia Antipolis, 06560 Valbonne, France
    Annu Rev Biochem 77:495-520. 2008
  5. ncbi An envelope-determined endocytic route of viral entry allows HIV-1 to escape from secreted phospholipase A2 entry blockade
    Thomas Maurin
    INSERM U526, Laboratoire de Virologie, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 2, France
    J Mol Biol 367:702-14. 2007
  6. ncbi Secretory low-molecular-weight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: factors of chronic proliferative cholangitis
    J Shoda
    Department of Gastroenterology, Institute of Clinical Medicine, The University of Tsukuba, Ibaraki, Japan
    Hepatology 29:1026-36. 1999
  7. pmc Occupational exposure to the risk of HIV infection among health care workers in Mwanza Region, United Republic of Tanzania
    B Gumodoka
    Bugando Medical Centre, Mwanza, United Republic of Tanzania
    Bull World Health Organ 75:133-40. 1997
  8. ncbi Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2
    E C Landucci
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil
    Toxicon 38:199-208. 2000
  9. pmc Patient characteristics, diagnosis, and treatment of non-contact lens related Acanthamoeba keratitis
    S Sharma
    Jhaveri Microbiology Centre, LV Prasad Eye Institute, LV Prasad Marg, Banjara Hills, Hyderabad 500 034, India
    Br J Ophthalmol 84:1103-8. 2000
  10. ncbi Risk for eye splash injury during administration of intraocular injections: a study of retina specialists and fellows
    Dan H Bourla
    Jules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, 200 Stein Plaza, Los Angeles, CA 90095, USA
    Retina 27:609-12. 2007

Research Grants

  1. Secretory Phospholipase A2s in Airway Pathophysiology
    Teal S Hallstrand; Fiscal Year: 2010
  2. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2006
  3. Biochemical Studies of 14-kDa Phospholipases A2
    Michael Gelb; Fiscal Year: 2007
  4. PHOSPHOLIPASE A2 AND VASCULAR WALL REMODELING
    GADIPARTHI RAO; Fiscal Year: 2007
  5. Regulation and Function of Cytosolic Phospholipase A2
    Michael H Gelb; Fiscal Year: 2010
  6. SPLA2 AND SURFACTANT IN ASTHMA
    David Bass; Fiscal Year: 2003
  7. MECHANISMS OF AIRWAY HYPERRESPONSIVENESS
    Alan Leff; Fiscal Year: 2005
  8. Role of Vimentin, sPLA2 and LysoPC in Autoimmune Disease
    SUZANNE BARBOUR; Fiscal Year: 2005
  9. Pilot--Secreted phospholipase A2 participate in neuronal
    MARK DECOSTER; Fiscal Year: 2002
  10. 5-LIPOXYGENASE PRODUCTS IN ASTHMATIC IMMUNE RESPONSE
    William Henderson; Fiscal Year: 2007

Detail Information

Publications148 found, 100 shown here

  1. ncbi Camphor Poisoning: an evidence-based practice guideline for out-of-hospital management
    Anthony S Manoguerra
    American Association of Poison Control Centers, Washington, District of Columbia 20016, USA
    Clin Toxicol (Phila) 44:357-70. 2006
    ..8) For patients with topical splash exposures of camphor to the eye(s), the eye(s) should be irrigated in accordance with usual poison center ..
  2. ncbi Heavy metals in bark of Pinus massoniana (Lamb.) as an indicator of atmospheric deposition near a smeltery at Qujiang, China
    Yuan Wen Kuang
    South China Botanical Garden, The Chinese Academy of Sciences, Guangzhou 510650, China
    Environ Sci Pollut Res Int 14:270-5. 2007
    ..The impact of the emission from smeltery on the soils beneath the trees and the relationships of the concentrations between the soils and the barks were also analyzed...
  3. ncbi Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2)
    Rao S Koduri
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 277:5849-57. 2002
    ..analyzed the bactericidal activity of the full set of recombinant murine and human groups I, II, V, X, and XII sPLA2s on Listeria monocytogenes, Staphylococcus aureus, and Escherichia coli...
  4. doi Biochemistry and physiology of mammalian secreted phospholipases A2
    Gerard Lambeau
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Universite de Nice Sophia Antipolis, 06560 Valbonne, France
    Annu Rev Biochem 77:495-520. 2008
    ..The mammalian genome contains 10 enzymatically active secreted PLA2s (sPLA2s) and two sPLA2-related proteins devoid of lipolytic enzymatic activity...
  5. ncbi An envelope-determined endocytic route of viral entry allows HIV-1 to escape from secreted phospholipase A2 entry blockade
    Thomas Maurin
    INSERM U526, Laboratoire de Virologie, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 2, France
    J Mol Biol 367:702-14. 2007
    ..Taken together, we conclude that HIV-1 may escape from entry inhibitors, such as sPLA2s, through the selection of a particular HIV-1 envelope glycoprotein that allows HIV to infect cells via an ..
  6. ncbi Secretory low-molecular-weight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: factors of chronic proliferative cholangitis
    J Shoda
    Department of Gastroenterology, Institute of Clinical Medicine, The University of Tsukuba, Ibaraki, Japan
    Hepatology 29:1026-36. 1999
    ..of the pathophysiology, interest has been focused on the role of secretory low-molecular-weight phospholipases A2 (sPLA2s) as inflammatory mediators or factors modulating cell functions via their specific sPLA2-receptor, and also on the ..
  7. pmc Occupational exposure to the risk of HIV infection among health care workers in Mwanza Region, United Republic of Tanzania
    B Gumodoka
    Bugando Medical Centre, Mwanza, United Republic of Tanzania
    Bull World Health Organ 75:133-40. 1997
    ..virus (HIV) transmission, availability of equipment, protective practices and the occurrence of prick and splash incidents in nine hospitals in the Mwanza Region in the north-west of the United Republic of Tanzania...
  8. ncbi Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2
    E C Landucci
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil
    Toxicon 38:199-208. 2000
    ..Rat paw oedema was induced by a single subplantar injection of the sPLA2s (5-30 microg/paw) in absence and presence of either crotapotin (10-100 microg/paw) or heparin (50 U/paw)...
  9. pmc Patient characteristics, diagnosis, and treatment of non-contact lens related Acanthamoeba keratitis
    S Sharma
    Jhaveri Microbiology Centre, LV Prasad Eye Institute, LV Prasad Marg, Banjara Hills, Hyderabad 500 034, India
    Br J Ophthalmol 84:1103-8. 2000
    ..To review the clinical characteristics, diagnosis, and visual outcome in patients with non-contact lens related Acanthamoeba keratitis and compare the findings with reported series of contact lens associated Acanthamoeba keratitis...
  10. ncbi Risk for eye splash injury during administration of intraocular injections: a study of retina specialists and fellows
    Dan H Bourla
    Jules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, 200 Stein Plaza, Los Angeles, CA 90095, USA
    Retina 27:609-12. 2007
    To evaluate the use of eye protection and frequency of eye splash events during intraocular injections as well as infection risk awareness among retina specialists and fellows in training.
  11. ncbi [Lightning injuries: case report of a 17-year-old man and a brief review of the literature]
    N Stutz
    Abteilung für Plastische, Hand und Wiederherstellungschirurgie, Zentrum für Schwerbrandverletzte, Klinikum Nürnberg Süd, Breslauerstrasse 201, 90471 Nürnberg
    Unfallchirurg 109:495-8. 2006
    ..We postulate that the mechanism by which lightning caused injury to this patient was a flash discharge (side splash)...
  12. doi Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom
    D O Toyama
    Centro de Cidncias Biológicas e da Saúde, Univesidade Mackenzie, Sao Paulo, Brazil
    Toxicon 53:417-26. 2009
    ..two-dimensional electrophoresis indicated an evident difference between HPLC-purified native and 7-HOC-treated sPLA2s, which were used in pharmacological experiments to compare their biological activities...
  13. ncbi HIV: awareness of management of occupational exposure in health care workers
    N Wig
    Department of Medicine, AIIMS, New Delhi 110 029
    Indian J Med Sci 57:192-8. 2003
    ..The present study was conducted to know the present knowledge regarding occupational exposure to HIV amongst doctors in non-governmental hospitals and clinics across Delhi...
  14. ncbi Sonographic findings of superior mesenteric artery syndrome causing massive gastric dilatation in a young healthy girl
    F M Abu-Zidan
    Department of Surgery, United Arab Emirates University, Al Ain, United Arab Emirates
    Singapore Med J 51:e184-6. 2010
    ..She was nauseated but was unable to vomit. Succussion splash was positive...
  15. ncbi Human neutrophil migration in vitro induced by secretory phospholipases A2: a role for cell surface glycosaminoglycans
    Alessandra Gambero
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, PO Box 6111, 13081 970, Campinas, SP, Brazil
    Biochem Pharmacol 63:65-72. 2002
    ..bothropstoxin-II, and piratoxin-I), and type III- (Apis mellifera venom) secretory phospholipases A2 (sPLA2s) to induce human neutrophil chemotaxis, and the role of the cell surface proteoglycans, leukotriene B4 (LTB4), and ..
  16. ncbi Variations of well water radon in Virginia and Maryland
    D G Mose
    Department of Chemistry, George Mason University, VA 22030, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 36:1647-60. 2001
    ..Aeration experiments on well water in storage tanks indicated that about 60-70% can be removed using a splash box with an exhaust fan on the storage tank, and about 60-70% can be removed using bubble aeration...
  17. ncbi Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachido
    Won K Han
    Medical Services, Massachusetts General Hospital, Department of Medicine and Anesthesia, Harvard Medical School, Massachusetts, USA
    J Biol Chem 278:24153-63. 2003
    ..We investigated the cross-talk between group IValpha cytosolic PLA2 (cPLA2alpha) and secretory PLA2s (sPLA2s) during H2O2-induced arachidonic acid (AA) release using two types of murine MC: (i)...
  18. ncbi Use of terminal tap water filter systems for prevention of nosocomial legionellosis
    R P Vonberg
    Division of Hospital Epidemiology and Infection Control, Institute for Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Hosp Infect 60:159-62. 2005
    ..Therefore, pathogen-free water should be provided for such high-risk patients. Surveillance of splash water was performed in high-risk patient care areas at Berlin Charité-University Medicine (506 samples) and ..
  19. ncbi Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor
    Y Morioka
    Shionogi Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    Arch Biochem Biophys 381:31-42. 2000
    ..release of arachidonic acid with significant production of prostaglandin E2 more efficiently than group IB and IIA sPLA2s. In addition, sPLA2-X was identified as a high-affinity ligand for both native and recombinant form of mouse PLA2 ..
  20. pmc Formation of multilayered photosynthetic biofilms in an alkaline thermal spring in Yellowstone National Park, Wyoming
    Sarah M Boomer
    Western Oregon University, Department of Biology, Monmouth, Oregon 97361, USA
    Appl Environ Microbiol 75:2464-75. 2009
    ..used as a substratum to promote the development of biofilms that resembled multilayered mat communities in the splash zone at the geyser's source...
  21. doi Needlestick and other potential blood and body fluid exposures among health care workers in British Columbia, Canada
    Hasanat Alamgir
    Statistics and Evaluation Department, Occupational Health and Safety Agency for Healthcare, Vancouver, British Columbia, Canada
    Am J Infect Control 36:12-21. 2008
    ..Health care workers have high risk of exposure to human blood and body fluids (BBF) from patients in acute care and residents in nursing homes or personal homes...
  22. ncbi Should eye protection be worn during dermatological surgery: prospective observational study
    A J Birnie
    Department of Dermatology, Queen s Medical Centre, Nottingham, UK
    Br J Dermatol 156:1258-62. 2007
    There is a potential risk of infection with blood-borne viruses if a doctor receives a blood splash to a mucous membrane...
  23. pmc Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation
    Hiroyasu Sato
    Department of Biological Sciences, Graduate School of Humanities and Sciences, Ochanomizu University, 2 1 1 Ohtsuka, Bunkyo ku, Tokyo 112 8610, Japan
    Biochem J 421:17-27. 2009
    ..III is an atypical sPLA2 (secretory PLA2) that is homologous with bee venom PLA2 rather than with other mammalian sPLA2s. In the present paper, we show that endogenous group III sPLA2 (PLA2G3) is expressed in mouse skin and that Tg (..
  24. ncbi Runoff and leaching of atrazine and alachlor on a sandy soil as affected by application in sprinkler irrigation
    A R Abdel Rahman
    Plant Protection Department, Desert Research Center, Mataria, Cairo, Egypt
    J Environ Sci Health B 34:381-96. 1999
    ..The design of the boxes allowed a measurement of pesticide concentrations in splash water throughout the rainfall event. Initial atrazine concentrations exceeding its' solubility were observed...
  25. ncbi The status of occupational safety among health service providers in hospitals in Tanzania
    S V Manyele
    Department of Chemical and Process Engineering, College of Engineering and Technology, University ofDar es Salaam, PO Box 35131, Dar es Salaam, Tanzania
    Tanzan J Health Res 10:159-65. 2008
    ..Needlestick injuries accounted for the largest part of the most common accidents (52.9%); followed by splash of blood from patients (21.7%); burn injury from chemicals (10.6%); and slippery floors (5.9%)...
  26. pmc Blood and body fluid splashes during surgery--the need for eye protection and masks
    C G Davies
    Department of Surgery, Salisbury District Hospital, Salisbury, UK
    Ann R Coll Surg Engl 89:770-2. 2007
    ..injury, some can pay little attention to reduce the potential route of infection occurring when body fluids splash into the eye. It has been shown that transmission of HIV, hepatitis B or C can occur across any mucous membrane...
  27. ncbi Reusable terminal tap water filters for nosocomial legionellosis prevention
    Ralf Peter Vonberg
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Ann Hematol 84:403-5. 2005
    ..with reusable water filters, a surveillance of splash water samples was performed. After determining the burden of Legionella spp...
  28. ncbi Neuropathogenesis of herpesvirus papio 2 in mice parallels infection with Cercopithecine herpesvirus 1 (B virus) in humans
    Kristin M Rogers
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078 2007, USA
    J Gen Virol 87:267-76. 2006
    ..was consistently neurovirulent when administered by epidermal scarification, intracranial inoculation and an eye splash. Quantitative real-time PCR, histopathology and immunohistochemistry were used to follow the temporal spread of ..
  29. ncbi Blood splash from different diathermy instruments during tonsillectomy
    B C Hanna
    Department of ENT, Antrim Area Hospital, Antrim, Northern Ireland, UK
    J Laryngol Otol 120:927-31. 2006
    ..To compare the potential risk of blood contamination of the surgeon's conjunctiva during tonsillectomy using disposable bipolar diathermy and reusable monopolar diathermy...
  30. doi Blood exposure risk during procedural dermatology
    Ruth D Holzmann
    Department of Dermatology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Acad Dermatol 58:817-25. 2008
    ..Dermatologists are at risk of body-fluid contamination during procedures...
  31. doi Geographic variation of persistent organic pollutant levels in humpback whale (Megaptera novaeangliae) feeding areas of the North Pacific and North Atlantic
    Cristiane T Elfes
    Washington Cooperative Fish and Wildlife Research Unit, School of Aquatic and Fishery Sciences, University of Washington, 1122 NE Boat Street, Box 355020, Seattle, Washington 98195, USA
    Environ Toxicol Chem 29:824-34. 2010
    ..Biopsy blubber samples from male individuals (n = 67) were collected through SPLASH, a multinational research project, in eight North Pacific feeding grounds...
  32. doi Effects of Marapuama in the chronic mild stress model: further indication of antidepressant properties
    Angelo L Piato
    Laboratorio de Etnofarmacologia, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Avenida Sarmento Leite 500 202, Porto Alegre, RS 90050 170, Brazil
    J Ethnopharmacol 118:300-4. 2008
    ..Suggestive of antidepressant activity, we have established that a specific PO ethanol extract (POEE) significantly decreases immobility in the tail suspension and forced swimming tests...
  33. ncbi Occupational exposures to blood in a dental teaching environment: results of a ten-year surveillance study
    F S Younai
    Section of Oral Biology and Medicine, University of California, Los Angeles School of Dentistry, 90095 1668, USA
    J Dent Educ 65:436-48. 2001
    ..Of these, 494 (98 percent) were percutaneous, and 10 (2 percent) were mucosal, each involving a splash to the eye of the dental care worker (DCW). Among the 504 exposures, 414 (82...
  34. ncbi Methods for determining the barrier efficacy of surgical gowns
    E A McCullough
    Institute for Environmental Research, Kansas State University, Manhattan 66506
    Am J Infect Control 21:368-74. 1993
    ..of laundering and sterilizing on the barrier efficacy of reusable gowns by means of the Impact Penetration (splash) Test, the Synthetic Blood Resistance Test, the Viral Resistance Test, and the Elbow Lean (demonstration) Test...
  35. pmc Do modern spectacles endanger surgeons? The Waikato Eye Protection Study
    Simon J Chong
    Department of Plastic and Reconstructive Surgery, Waikato Hospital, Hamilton, New Zealand
    Ann Surg 245:495-501. 2007
    ..Modern fashion spectacles, being of increasingly slim design, may no longer be adequate in this role...
  36. ncbi [Procedure in case of exposure of hospital's workers to HBV, HCV and HIV]
    Maciej Dancewicz
    Katedra i Klinika Chirurgii Klatki Piersiowej i Nowotworów Collegium Medicum im L Rydygiera w Bydgoszczy Uniwersytetu Mikołaja Kopernika w Toruniu
    Przegl Epidemiol 59:671-7. 2005
    ..blood collection or injections (34 cases), as a result of a scalpel or other surgical instrument cut (2 cases), a splash of infectious material on the skin and conjunctivae (4 cases) and in the singular cases as a result of a bite by a ..
  37. ncbi [Safety issues of chemo drug administration handling by nurses from an occupational exposure viewpoint-through visualization with contrast media for ophthalmic vasculature]
    Kentaro Terui
    Department of Nursing, Iwamizawa Municipal General Hospital
    Gan To Kagaku Ryoho 37:1931-5. 2010
    ..The result showed spills all over in the procedures by nurses in the study: specifically splash to environment around the drug preparation area, contamination of needles which were used for drug preparations, ..
  38. ncbi The functions of five distinct mammalian phospholipase A2S in regulating arachidonic acid release. Type IIa and type V secretory phospholipase A2S are functionally redundant and act in concert with cytosolic phospholipase A2
    M Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Biol Chem 273:14411-23. 1998
    ..of five distinct mammalian phospholipase A2 (PLA2) enzymes (cytosolic PLA2 (cPLA2; type IV), secretory PLA2s (sPLA2s; types IIA, V, and IIC), and Ca2+-independent PLA2 (iPLA2; type VI)) to arachidonic acid (AA) metabolism by ..
  39. ncbi Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation
    Sabine Beck
    Center of Pharmacology, University Hospital Frankfurt, 60590 Frankfurt, Germany
    J Biol Chem 278:29799-812. 2003
    In rat mesangial cells, exogenously added secreted phospholipases A2 (sPLA2s) potentiate the expression of pro-inflammatory sPLA2-IIA first induced by cytokines like tumor necrosis factor-alpha (TNFalpha) and interleukin-1 beta...
  40. ncbi Effect of Cherenkov radiation on the jitter of solitons in the driven underdamped Frenkel-Kontorova model
    I I Soloviev
    Skobeltsyn Institute of Nuclear Physics, Moscow State University, Moscow 119991, Russia
    Phys Rev E Stat Nonlin Soft Matter Phys 87:060901. 2013
    ..In contrast to the continuous case, we have observed a dramatic splash of the jitter...
  41. ncbi Splish splash... Adding alcohol-based handrubs to hand hygiene routines contributes to patient safety, saves lives and adds to operational efficiency
    Janice Olson
    Contemp Longterm Care 27:34-5. 2004
  42. pmc Inbreeding depression in urban environments of the bird's nest fungus Cyathus stercoreus (Nidulariaceae: Basidiomycota)
    B D Malloure
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Heredity (Edinb) 110:355-62. 2013
    ..dispersal and inbreeding in the bird's nest fungus Cyathus stercoreus, a dung and mulch-associated fungus with a splash cup fruiting body appearing like a miniature bird's nest of 'eggs' or peridioles that contain thousands of mating ..
  43. doi Laboratory evaluation of thermal protective clothing performance upon hot liquid splash
    Farzan Gholamreza
    Human Ecology Department, University of Alberta, Human Ecology Building, Edmonton, Alberta T6G 2N1, Canada
    Ann Occup Hyg 57:805-22. 2013
    This study provides an understanding of heat and mass transfer through materials exposed to hot liquid splash, a relatively unexplored hazard in the safety clothing industry...
  44. pmc Secreted phospholipases A2 of snake venoms: effects on the peripheral neuromuscular system with comments on the role of phospholipases A2 in disorders of the CNS and their uses in industry
    John B Harris
    Medical Toxicology Centre and Institute of Neurosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Toxins (Basel) 5:2533-71. 2013
    ..This review provides an introduction to the biochemical properties of secreted sPLA2s in the venoms of many dangerous snakes and a detailed discussion of their role in the initiation of the ..
  45. ncbi Impact of granular drops
    J O Marston
    Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal 23955 6900, Saudi Arabia
    Phys Rev E Stat Nonlin Soft Matter Phys 88:010201. 2013
    ..The speeds of the grains ejected during the "splash" are measured and they rarely exceed twice that of the impact speed.
  46. pmc Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry
    Yuan Hao Hsu
    Department of Chemistry, Tunghai University, Taichung, Taiwan
    PLoS ONE 8:e59267. 2013
    ..The sPLA2s caused an accumulation of dilyso-cardiolipin, in contrast to iPLA2 which caused an accumulation of monolyso-..
  47. ncbi Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol
    Ipek Yalcin
    EA 3248 Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite Francois Rabelais, Parc Grandmont F 37200 Tours, France
    Eur J Pharmacol 514:165-74. 2005
    ..mild stress regimen induced a degradation of the state of the coat and decreased the grooming behaviour in the splash test. These physical and behavioural abnormalities were counteracted by tramadol and desipramine...
  48. ncbi Basic amino acid residues in the beta-structure region contribute, but not critically, to presynaptic neurotoxicity of ammodytoxin A
    Gabriela Ivanovski
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biochim Biophys Acta 1702:217-25. 2004
    The molecular mechanism of action of presynaptically toxic secreted phospholipases A2 (sPLA2s) isolated from snake venoms is not completely understood...
  49. ncbi Diphoterine for emergent decontamination of skin/eye chemical splashes: 24 cases
    Jochen Nehles
    Mannesmann Hoesch Prazisrohr, Remscheid, Germany
    Cutan Ocul Toxicol 25:249-58. 2006
    ..There were 11 acid eye splashes, 8 acid skin splashes, 4 base eye splashes, and 1 base skin splash. Following Diphoterine decontamination, no burns developed and there were no requirements for burn treatment or ..
  50. ncbi Laboratory evaluation of a potential diesel fuel interference in the determination of polycyclic aromatic compounds on dermal samplers
    Robert A Weker
    Harvard School of Public Health, Department of Environmental Health, Boston, Massachusetts 02115, USA
    J Occup Environ Hyg 1:334-42. 2004
    ..Diesel fuel used for cleaning can splash onto the dermal sampler...
  51. ncbi Recommendations for prevention of and therapy for exposure to B virus (cercopithecine herpesvirus 1)
    Jeffrey I Cohen
    Medical Virology Section, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Infect Dis 35:1191-203. 2002
    ..inoculation with infected materials; however, the first fatal case of B virus infection due to mucosal splash exposure was reported in 1998...
  52. ncbi Selective oviposition of the mayfly Baetis bicaudatus
    Andrea C Encalada
    Department of Entomology, Cornell University, Ithaca, NY, 14850, USA
    Oecologia 148:526-37. 2006
    ..and experiments showed that females preferred to oviposit under relatively large rocks located in places with high splash associated with fast current, which may provide visual, mechanical or both cues to females...
  53. pmc Splash-cup plants accelerate raindrops to disperse seeds
    Guillermo J Amador
    School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    J R Soc Interface 10:20120880. 2013
    The conical flowers of splash-cup plants Chrysosplenium and Mazus catch raindrops opportunistically, exploiting the subsequent splash to disperse their seeds...
  54. ncbi Hand surgery on patients who are "high risk" for blood-borne viruses
    S A Al-Ani
    Department of Plastic Surgery, Castle Hill Hospital, Cottingham, UK
    J Hand Surg Br 31:426-31. 2006
    ..When possible, wounds should be closed with staples, glue or absorbable sutures. Appropriate steps must be taken to reduce the risk of injuries from sharp bone ends, K-wires and splash exposure during irrigation.
  55. doi Occupational exposure to blood and other body fluids among health care workers at a university hospital in Iran
    Hamid Reza Naderi
    Mashhad University of Medical Sciences, Mashhad, Iran
    Workplace Health Saf 60:419-22. 2012
    Occupational exposure to sharp items or body fluid splash is a hazard for health care personnel via transmission of blood-borne viruses through such exposures...
  56. pmc Using the image analysis method for describing soil detachment by a single water drop impact
    Magdalena Ryżak
    Institute of Agrophysics, Polish Academy of Sciences, Doswiadczalna 4, 20 290 Lublin, Poland
    Sensors (Basel) 12:11527-43. 2012
    ..Additionally, the following relationships were determined: (i) the distances of splash; (ii) the surface areas of splash tracks into relation to distance; (iii) the surface areas of the solid phase ..
  57. pmc Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease
    Sarah Gora
    INSERM, UMRS937, UPMC Université Paris 06 and Faculté de Médecine Pierre et Marie Curie, 91, Boulevard de l Hopital, 75634, Paris, France
    J Mol Med (Berl) 87:723-33. 2009
    Among secreted phospholipases A2 (sPLA2s), human group X sPLA2 (hGX sPLA2) is emerging as a novel attractive therapeutic target due to its implication in inflammatory diseases...
  58. doi Acetic-acid-mediated miscibility toward electrospinning homogeneous composite nanofibers of GT/PCL
    Bei Feng
    State Key Laboratory for Modification of Chemical Fibers and Polymer Materials and College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
    Biomacromolecules 13:3917-25. 2012
    ..This consequently led to gradually deteriorated fiber morphologies (e.g., splash, fiber bonding, and varied fiber size) over time during electrospinning GT/PCL...
  59. ncbi Occupational exposure of health workers to blood and body fluids in six hospitals of Tigray region (August 1-30, 2006): magnitude and management
    Amanuel Gessessew
    Department of Gynecology, Mekele Hospital, Tigray
    Ethiop Med J 47:213-9. 2009
    ..Needle stick injuries, blood and body fluids contact to non-intact skin and accidental splash to the mucus membrane are known to transmit infections...
  60. ncbi Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor
    Morgane Rouault
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    Biochemistry 46:1647-62. 2007
    To date, 12 secreted phospholipases A2 (sPLA2s) have been identified in the mouse species and divided into three structural collections (I/II/V/X, III, and XII)...
  61. doi Animal feasibility study of an innovated splash-needle for endoscopic submucosal dissection in the upper gastrointestinal tract
    Mitsuhiro Fujishiro
    Department of Endoscopy and Endoscopic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Dig Endosc 25:7-12. 2013
    ..The objective of the present study was to investigate the feasibility of an innovated splash-needle for ESD.
  62. pmc Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines' unexpected therapeutic properties
    Timothy J Cunningham
    Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Inflamm (Lond) 5:17. 2008
    ..We demonstrate that specific lysoPCs act as uncompetitive product inhibitors of plasma secreted PLA2 enzymes (sPLA2s), especially under conditions of elevated enzyme activity, thus providing a feedback mechanism for the observed ..
  63. ncbi Effect of time of day and duration into shift on hazardous exposures to biological fluids
    D J Macias
    University of New Mexico, Department of Emergency Medicine, Albuquerque, USA
    Acad Emerg Med 3:605-10. 1996
    ..To determine whether hospital employee biological hazardous exposure rates varied with time of day or increased with time interval into shift...
  64. ncbi Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII)
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 278:10657-67. 2003
    ..Based on the present results as well as our current analyses on the group I/II/V/X sPLA(2)s, general properties of cellular actions of a full set of mammalian sPLA(2)s in regulating AA metabolism are discussed...
  65. ncbi Secretory phospholipase A2
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Biol Pharm Bull 27:1158-64. 2004
    ..b>sPLA2s are distributed in a wide variety of vertebrate and invertebrate animals, plants, bacteria, and viruses, and there ..
  66. ncbi Secreted phospholipase A2-induced neurotoxicity and epileptic seizures after intracerebral administration: an unexplained heterogeneity as emphasized with paradoxin and crotoxin
    F Dorandeu
    Department of Toxicology, Unit of Neuropharmacology, Centre de Recherches du Service de Sante des Armees, La Tronche, France
    J Neurosci Res 54:848-62. 1998
    ..The results obtained with the other enzymes showed that toxic sPLA2s can effectively be differentiated based on two criteria: the presence of cortically recorded epileptic paroxysmal ..
  67. ncbi Expression profile of proinflammatory genes in neutrophil-enriched granulocytes stimulated with native anti-PR3 autoantibodies
    M Surmiak
    Division of Molecular Biology and Clinical Genetics, Department of Medicine, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 63:249-56. 2012
    ..some donors (IL13, PF4, IL2RG, ITGB1, CD83, PLA2G7, ALOX12, AXNA1, AXNA5, LTA4H, MCR2) yet two others (HRH3 and PLA2G2D) were up-regulated in a few samples and undetectable in others...
  68. ncbi Study of audio speakers containing ferrofluid
    R E Rosensweig
    34 Gloucester Road, Summit, NJ 07901, USA
    J Phys Condens Matter 20:204147. 2008
    ..In addition, a study is made of factors influencing splash loss of the ferrofluid due to shock...
  69. ncbi Cloning and recombinant expression of a novel mouse-secreted phospholipase A2
    E Valentin
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, UPR 411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 274:19152-60. 1999
    Secreted phospholipases A2 (sPLA2s) form a class of structurally related enzymes that are involved in a variety of physiological and pathological effects including inflammation and associated diseases, cell proliferation, cell adhesion, ..
  70. ncbi Salmonella transmission through splash exposure during a bovine necropsy
    David A Bemis
    Department of Comparative Medicine, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee 37996, USA
    Foodborne Pathog Dis 4:387-90. 2007
    ..The isolates had indistinguishable phenotypic and genotypic characteristics. A splash exposure was the suspected means of transmission of the human infection...
  71. ncbi Characterization of a cDNA encoding Arabidopsis secretory phospholipase A2-alpha, an enzyme that generates bioactive lysophospholipids and free fatty acids
    Stephen B Ryu
    Department of Horticulture, University of Wisconsin, 1575 Linden Drive, Madison, WI 53706, USA
    Biochim Biophys Acta 1736:144-51. 2005
    ..Different from animal sPLA2s, AtsPLA2-alpha showed a significant preference for the acyl group linoleic acid over palmitic acid in phospholipid ..
  72. ncbi Potential for a hazardous geospheric response to projected future climate changes
    B McGuire
    Aon Benfield UCL Hazard Research Centre, Department of Earth Sciences, University College London, Gower Street, London WC1E 6BT, UK
    Philos Transact A Math Phys Eng Sci 368:2317-45. 2010
    ..phenomena, including volcanic and seismic activity, submarine and subaerial landslides, tsunamis and landslide 'splash' waves, glacial outburst and rock-dam failure floods, debris flows and gas-hydrate destabilization...
  73. doi Stabilization and modulation of the phycobilisome by calcium in the calciphilic freshwater red alga Bangia atropurpurea
    Makio Yokono
    Molecular Photoscience Research Center, Kobe University, Kobe, Hyogo, Japan
    Biochim Biophys Acta 1817:306-11. 2012
    ..bangiophycean filamentous red alga Bangia atropurpurea is distributed in freshwater habitats such as littoral and splash zones of lakes or rapid currents distant from the sea...
  74. doi Occurrence and antibiotic resistance of multiple Salmonella serotypes recovered from water, sediment and soil on mid-Atlantic tomato farms
    Shirley A Micallef
    Maryland Institute for Applied Environmental Health, School of Public Health, University of Maryland, 2234P SPH Building, College Park, MD 20742, USA
    Environ Res 114:31-9. 2012
    ..The findings point to the potential for pre-harvest contamination of tomatoes from contaminated irrigation water or from soil or water splash from irrigation ditches onto low-lying portions of tomato plants.
  75. ncbi Creation of prompt and thin-sheet splashing by varying surface roughness or increasing air pressure
    Andrzej Latka
    The James Franck Institute, The University of Chicago, Illinois 60637, USA
    Phys Rev Lett 109:054501. 2012
    A liquid drop impacting a solid surface may splash either by emitting a thin liquid sheet that subsequently breaks apart or by promptly ejecting droplets from the advancing liquid-solid contact line...
  76. ncbi Needlesticks injuries in dentistry
    N Gupta
    Department of Periodontics, Shree Bankey Bihari Dental College and Research Centre, India
    Kathmandu Univ Med J (KUMJ) 9:208-12. 2011
    ..Dentists should remember and apply many precautions to prevent the broad spectrum of sharps and splash injuries that could occur during the delivery of dental care.
  77. ncbi Splash control of drop impacts with geometric targets
    Gabriel Juarez
    Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 85:026319. 2012
    ..We propose that regular splashes are controlled by the azimuthal perturbations imposed by the target cross-sectional geometry and that irregular splashes are governed by the fastest-growing unstable Plateau-Rayleigh mode...
  78. doi Distribution and decline of human pathogenic bacteria in soil after application in irrigation water and the potential for soil-splash-mediated dispersal onto fresh produce
    J M Monaghan
    Fresh Produce Research Centre, Harper Adams University College, Newport, Shropshire, UK
    J Appl Microbiol 112:1007-19. 2012
    To improve our understanding of the survival and splash-mediated transfer of zoonotic agents and faecal indicator bacteria introduced into soils used for crop cultivation via contaminated irrigation waters.
  79. doi The role of rain in dispersal of the primary inoculum of Plasmopara viticola
    Vittorio Rossi
    Instituto di Entomologia e Patologia Vegetale, Universita Cattolica del Sacro Cuore, Via Parmense 84, 29122 Piacenza, Italy
    Phytopathology 102:158-65. 2012
    Although primary infection of grapevines by Plasmopara viticola requires splash dispersal of inoculum from soil to leaves, little is known about the role of rain in primary inoculum dispersal...
  80. doi Survival, dispersal, and potential soil-mediated suppression of Phytophthora ramorum in a California redwood-tanoak forest
    E J Fichtner
    Department of Plant Pathology, University of California Davis, Davis, CA 95616, USA
    Phytopathology 99:608-19. 2009
    ..cycle is not well understood, this work addresses survival, chlamydospore production, pathogen suppression, and splash dispersal of the pathogen in infested forest soils...
  81. doi Imported Salmonella Enteritidis cases: a multiphage outbreak among Austrian vacationers in Turkey, 2008
    Sabine S Kasper
    Agentur für Gesundheit und Ernährungssicherheit AGES, Wien, Austria
    Wien Klin Wochenschr 121:144-8. 2009
    ..of Salmonella Enteritidis infection among high school graduates was associated with the 2008 three-week Summer Splash event in Turkey...
  82. doi Echolocation by two foraging harbour porpoises (Phocoena phocoena)
    Ursula K Verfuss
    Fjord and Baelt, Margrethes Plads 1, DK 5300 Kerteminde, Denmark
    J Exp Biol 212:823-34. 2009
    ..One animal repeated the tasks blindfolded. A splash generated by the fish being thrown into the pool or - in controls - by a boat hook indicated prey and stimulated ..
  83. doi Safety of dermal diphoterine application: an active decontamination solution for chemical splash injuries
    Alan H Hall
    Toxicology Consulting and Medical Translating Services, Inc, Laramie, Wyoming 82072, USA
    Cutan Ocul Toxicol 28:149-56. 2009
    ..Diphoterine can be used, even on damaged skin, without toxic, irritant, allergenic, or sensitizing effects...
  84. doi Technical feasibility of endoscopic submucosal dissection of gastrointestinal epithelial neoplasms with a splash-needle
    Mitsuhiro Fujishiro
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Surg Laparosc Endosc Percutan Tech 18:592-7. 2008
    ..This novel knife is known as the "splash-needle," and it is thin, short needle with a water-irrigation function...
  85. doi ARCS-Motif: discovering correlated motifs from unaligned biological sequences
    Shijie Zhang
    Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA
    Bioinformatics 25:183-9. 2009
    ..The paper showed that the ARCS measure is superior to other measures. Due to the complicated nature of the ARCS motif model, we cannot directly apply existing sequential motif discovery methods to find motifs with high ARCS values...
  86. ncbi SPLASH: structural pattern localization analysis by sequential histograms
    A Califano
    IBM TJ Watson Research Center, PO Box 704, Yorktown Heights, NY 10598, USA
    Bioinformatics 16:341-57. 2000
    ..Similar arguments may be applied to conserved DNA patterns. Available sparse pattern discovery algorithms are either inefficient or impose limitations on the type of patterns that can be discovered...
  87. ncbi [Clinical application of pulsed laser-induced liquid jet: preliminary report in glioma surgery]
    Atsuhiro Nakagawa
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai shi, Miyagi 980 8574, Japan
    No Shinkei Geka 36:1005-10. 2008
    ..To overcome these issues, we have developed pulsed holmium: yttrium-aluminum-garnet (YAG) laser-induced liquid jet (LILJ) for microsugical use and applied it in glioma surgery...
  88. doi Occupational exposure to blood and other bodily fluids at a military hospital in Iraq
    Clinton K Murray
    Infectious Disease Service, San Antonio Military Medical Center, Fort Sam Houston, Texas 78234, USA
    J Trauma 66:S62-8. 2009
    ....
  89. doi Is repetitive intraoperative splash basin use a source of bacterial contamination in total joint replacement?
    Sergio A Glait
    Department of Orthopedic Surgery, NYU Hospital for Joint Diseases, New York, New York, USA
    Orthopedics 34:e546-9. 2011
    b>Splash basins are used in arthroplasty cases to wash instruments. Several studies in the literature have shown these basins being a potential source of bacterial infection...
  90. doi Extracellular phospholipases in atherosclerosis
    Sonia Athina Karabina
    INSERM UMRS 937, Université Pierre et Marie Curie UPMC Paris 6, Faculte de Medecine Pierre et Marie Curie, 91 Boulevard de l Hopital, Paris 75634 Cedex 13, France
    Biochimie 92:594-600. 2010
    ..In contrast to other sPLA2s, including group IB, IIA and V, PLA2GX can efficiently hydrolyze PAF present in lipoproteins or vesicles ..
  91. doi Effect of the synthetic coumarin, ethyl 2-oxo-2H-chromene-3-carboxylate, on activity of Crotalus durissus ruruima sPLA2 as well as on edema and platelet aggregation induced by this factor
    F V Fonseca
    Biochemistry Department, Institute of Biology, UNICAMP, Campinas, Brazil
    Toxicon 55:1527-30. 2010
    ..EOCC strongly decreased the V(max) and K(m), and it virtually abolished the enzyme activity of sPLA2r as well as sPLA2s from other sources...
  92. ncbi Impact of a viscous liquid drop
    Robert D Schroll
    Physics Department and the James Franck Institute, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
    Phys Rev Lett 104:034504. 2010
    ..As in experiments, when ambient air effects are negligible, impact flattens the falling drop without producing a splash. The no-slip boundary condition at the wall produces a boundary layer inside the liquid...
  93. doi Phospholipolyzed LDL induces an inflammatory response in endothelial cells through endoplasmic reticulum stress signaling
    Sarah Gora
    INSERM UMRS 937, Universite Pierre et Marie Curie, UPMC Paris 6, Paris, France
    FASEB J 24:3284-97. 2010
    Secreted phospholipases A2 (sPLA2s) are present in atherosclerotic plaques and are now considered novel attractive therapeutic targets and potential biomarkers as they contribute to the development of atherosclerosis through lipoprotein-..
  94. pmc Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: a model of fluoxetine resistance in mice
    Elsa Isingrini
    UMRS Unité mixte de recherche INSERM U930 Institut national de la santé et de la recherche médicale, CNRS Centre national de la recherche scientifique ERL Equipes de recherche labélisées 3106, Universite Francois Rabelais, Tours, France
    PLoS ONE 5:e10404. 2010
    ..were assessed using physical (coat state and body weight) and behavioural tests (the reward maze test and the splash test)...
  95. doi Purification of tetracysteine-tagged proteins by affinity chromatography using a non-fluorescent, photochemically stable bisarsenical affinity ligand
    Lai Qiang Ying
    Life Technologies, 29851 Willow Creek Road, Eugene, OR 97402, United States
    Bioconjug Chem 22:987-92. 2011
    ..tagged proteins has been achieved using a nonfluorescent, photochemically stable bisarsenical affinity ligand SplAsH. The photochemical stability of the SplAsH-biotin, shown in compound 5, is superior to FlAsH-EDT(2) and ReAsH-EDT(..
  96. ncbi Precursors to splashing of liquid droplets on a solid surface
    Shreyas Mandre
    School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA
    Phys Rev Lett 102:134502. 2009
    A high velocity impact between a liquid droplet and a solid surface produces a splash. Classical work traced the origin of the splash to a thin sheet of fluid ejected near the impact point...
  97. ncbi Nonhygienic behavior, knowledge, and attitudes among interactive splash park visitors
    Randall J Nett
    Centers for Disease Control and Prevention, Montana Department of Public Health and Human Services, Helena, MT 59620, USA
    J Environ Health 73:8-14. 2010
    Nonhygienic behavior likely contributed to three recreational waterborne illness (RWI) outbreaks at Idaho splash parks...
  98. doi Pseudomonas syringae pv. phaseolicola: from 'has bean' to supermodel
    Dawn L Arnold
    Centre for Research in Plant Science, University of the West of England, Bristol BS16 1QY, UK
    Mol Plant Pathol 12:617-27. 2011
    ..In this review, we discuss several of the areas of study that chart the rise of P. syringae pv. phaseolicola from a common pathogen of bean plants to a molecular plant-pathogen supermodel bacterium...
  99. doi Splash in elective primary knee and hip replacement: are we adequately protected?
    V K Singh
    Luton and Dunstable Hospitals, NHS Foundation Trust, Lewsey Road, Luton LU40DZ, UK
    J Bone Joint Surg Br 91:1074-7. 2009
    An intra-operative splash is a common occurrence in elective knee and hip replacement surgery and can potentially transmit bloodborne diseases, with devastating consequences...
  100. doi Use of a surgical helmet system to minimize splash injury during percutaneous renal surgery in high-risk patients
    Jonathan A Eandi
    Department of Urology, University of California, Davis Medical Center, Sacramento, California 95817, USA
    J Endourol 22:2655-6. 2008
    ..A recent study found 55% of surgeons' masks contain evidence of blood splash contamination after percutaneous nephrolithotomy...
  101. ncbi The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization
    P Ancian
    Institut de Pharmacologie Moleculaire et Cellulaire, Sophia Antipolis, Valbonne, France
    J Biol Chem 270:8963-70. 1995
    ..Some of these effects are apparently linked to the existence of specific receptors for both venom and mammalian sPLA2s. We report here the molecular cloning and expression of one of these sPLA2 receptors from human kidney...

Research Grants62

  1. Secretory Phospholipase A2s in Airway Pathophysiology
    Teal S Hallstrand; Fiscal Year: 2010
    b>Secretory Phospholipase A2s in Airway Pathophysiology. Dysregulated eicosanoid synthesis plays a central role in the immunobiology of asthma...
  2. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2006
    ..Mammalian cells contain two types of PLA2s that are involved in arachidonic acid production. The secreted PLA2s (sPLA2s) are 14-18 kDa, calcium-dependent enzymes that are secreted from a large number of mammalian cells following ..
  3. Biochemical Studies of 14-kDa Phospholipases A2
    Michael Gelb; Fiscal Year: 2007
    ..The mammalian genome encodes 10 secreted phospholipases Aa (sPLA2s), and the role of these enzymes in mediating arachidonic acid release is under active investigation...
  4. PHOSPHOLIPASE A2 AND VASCULAR WALL REMODELING
    GADIPARTHI RAO; Fiscal Year: 2007
    ..identified to date, evidence indicates for an involvement of both cytosolic and secretary type PLA2s (cPLA2 and sPLA2s) in inflammation...
  5. Regulation and Function of Cytosolic Phospholipase A2
    Michael H Gelb; Fiscal Year: 2010
    ..We will also study the role of cPLA2s and secreted phospholipases A2 (sPLA2s) in lipid mediator production from human platelets stimulated with a variety of agonists...
  6. SPLA2 AND SURFACTANT IN ASTHMA
    David Bass; Fiscal Year: 2003
    ..Little is known about the pulmonary distribution or functions of these potentially toxic sPLA2S. The central hypothesis of the proposal is that the five isotypes of sPLA2 will have distinct cellular ..
  7. MECHANISMS OF AIRWAY HYPERRESPONSIVENESS
    Alan Leff; Fiscal Year: 2005
    ..The final (third) aim of this proposal will examine the molecular mechanism of binding of sPLA2s to the plasma membrane...
  8. Role of Vimentin, sPLA2 and LysoPC in Autoimmune Disease
    SUZANNE BARBOUR; Fiscal Year: 2005
    ..To test this hypothesis, we will further characterize the interactions between vimentin and the sPLA2s, in particular the group V enzyme that readily hydrolyzes the zwitterionic phospholipids in the outer leaflet of ..
  9. Pilot--Secreted phospholipase A2 participate in neuronal
    MARK DECOSTER; Fiscal Year: 2002
    This project will define the significance of secretory phospholipases A2 (sPLA2s) in neuronal signaling and injury...
  10. 5-LIPOXYGENASE PRODUCTS IN ASTHMATIC IMMUNE RESPONSE
    William Henderson; Fiscal Year: 2007
    ..The specific aims of this study are as follows: Specific Aim 1. Determine the Role of sPLA2s vs...
  11. Reconstruction and Modeling of Networks Involved in Cardiomyocyte Differentiation
    Juan Carlos Izpisua Belmonte; Fiscal Year: 2007
    ....
  12. Notch Signaling and Left-Right Asymmetry Determination
    Juan Carlos Izpisua Belmonte; Fiscal Year: 2007
    ..The study of the early stages of L-R determination and the identification of new genes involved in various vertebrate model organisms would undoubtedly shed new light on the genetic factors contributing to laterality defects in humans. ..
  13. SURVIVAL AND DEATH OF NEURONS
    TIMOTHY CUNNINGHAM; Fiscal Year: 1999
    ..The neurotoxicity of NMDA and non NMDA glutamate receptor agonists will be investigated and the effects of the 200kD factor on this toxicity (and associated changes in intracellular calcium) will be determined. ..
  14. NOTCH SIGNALING AND VERTEBRATE LIMB DEVELOPMENT
    Juan Carlos Izpisua Belmonte; Fiscal Year: 2003
    ....
  15. SURVIVAL AND DEATH OF NEURONS
    TIMOTHY CUNNINGHAM; Fiscal Year: 2003
    ..It is expected that these experiments will provide further insights into mechanisms and potential therapies for neuron degeneration after CNS injury and in nervous system diseases. ..
  16. Interaction of BMP, WNT and SHH in the Vertebrate Limb
    Juan Carlos Izpisua Belmonte; Fiscal Year: 2005
    ....