PLA2G1B

Summary

Gene Symbol: PLA2G1B
Description: phospholipase A2 group IB
Alias: PLA2, PLA2A, PPLA2, phospholipase A2, phosphatidylcholine 2-acylhydrolase 1B, phospholipase A2, group IB (pancreas)
Species: human

Top Publications

  1. ncbi Chromosomal assignment of the second locus for autosomal dominant cerebellar ataxia (SCA2) to chromosome 12q23-24.1
    S Gispert
    Department of Neurology, University Hospital, Duesseldorf, Germany
    Nat Genet 4:295-9. 1993
  2. ncbi Phospholipases A2 in ischemic and toxic brain injury
    A Sapirstein
    Anesthesia and Critical Care, Massachusetts General Hospital, Charlestown 02129, USA
    Neurochem Res 25:745-53. 2000
  3. pmc Inhibition of carrageenin-induced rat paw oedema by crotapotin, a polypeptide complexed with phospholipase A2
    E C Landucci
    Department of Biochemistry, UNICAMP, Campinas SP, Brazil
    Br J Pharmacol 114:578-83. 1995
  4. pmc Differential changes of adrenoceptor- and muscarinic receptor-linked prostacyclin synthesis by the aorta and urinary bladder of the diabetic rat
    J Y Jeremy
    Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, University of London
    Br J Pharmacol 108:1131-6. 1993
  5. pmc Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carrageenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2
    A Miyake
    Molecular and Cellular Pharmacology, Dept, Yamanouchi Pharmaceutical Co Ltd, Tokyo, Japan
    Br J Pharmacol 110:447-53. 1993
  6. ncbi Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI
    D W Snyder
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 288:1117-24. 1999
  7. pmc Up-regulation of [3H]-des-Arg10-kallidin binding to the bradykinin B1 receptor by interleukin-1 beta in isolated smooth muscle cells: correlation with B1 agonist-induced PGI2 production
    J P Galizzi
    Cerep, Celle l evescault, France
    Br J Pharmacol 113:389-94. 1994
  8. ncbi Intracerebral injection of phospholipase A2 inhibits dopamine-mediated behavior in rats: possible implications for schizophrenia
    J Brunner
    Neurobiology Unit, Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 246:13-6. 1995
  9. ncbi Pancreatic phospholipase A2--mediated enhancement of the respiratory burst response of human neutrophils
    J Muller
    Institute of Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Germany
    Z Naturforsch C 56:1150-6. 2001
  10. ncbi Affinity purification of phospholipase A2 on immobilized artificial membranes containing and lacking the glycerol backbone
    C Bernal
    Department of Medicinal Chemistry, School of Pharmacy, Perdue University, West Lafayette, IN 47907, USA
    J Chromatogr A 731:139-51. 1996

Research Grants

  1. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
  2. Studies of Eicosanoid Biosynthetic Proteins
    Wonhwa Cho; Fiscal Year: 2013
  3. Biology, Immunology &therapy of Acanthamoeba Keratitis
    Hassan Alizadeh; Fiscal Year: 2013
  4. Role of phospholipase A2 in spinal cord secondary injury
    Xiao Ming Xu; Fiscal Year: 2013
  5. Michael H Gelb; Fiscal Year: 2016
  6. CYTOSOLIC PHOSPHOLIPASE A2 TRANSFORMED CELLS
    Raphael Nemenoff; Fiscal Year: 2002
  7. Michael A Collins; Fiscal Year: 2016
  8. PHOSPHOLIPID TURNOVER IN EXOCRINE PANCREAS
    Ronald Rubin; Fiscal Year: 1991
  9. William M Nauseef; Fiscal Year: 2016
  10. DAVID YIU KWAN HUI; Fiscal Year: 2014

Detail Information

Publications338 found, 100 shown here

  1. ncbi Chromosomal assignment of the second locus for autosomal dominant cerebellar ataxia (SCA2) to chromosome 12q23-24.1
    S Gispert
    Department of Neurology, University Hospital, Duesseldorf, Germany
    Nat Genet 4:295-9. 1993
    ..1 following linkage analyses carried out for the Cuban pedigrees, with probable flanking markers D12S58 and phospholipase A2. Investigation of linkage to the interval containing SCA2 for seven French ADCA families, previously excluded ..
  2. ncbi Phospholipases A2 in ischemic and toxic brain injury
    A Sapirstein
    Anesthesia and Critical Care, Massachusetts General Hospital, Charlestown 02129, USA
    Neurochem Res 25:745-53. 2000
    ..We postulated that group IV large molecular weight, cytosolic phospholipase A2 (cPLA2) has a unique role in neurotoxicity associated with ischemic or toxin stress...
  3. pmc Inhibition of carrageenin-induced rat paw oedema by crotapotin, a polypeptide complexed with phospholipase A2
    E C Landucci
    Department of Biochemistry, UNICAMP, Campinas SP, Brazil
    Br J Pharmacol 114:578-83. 1995
    1. The effect of purified crotapotin, a non-toxic non-enzymatic chaperon protein normally complexed to a phospholipase A2 (PLA2) in South America rattlesnake venom, was studied in the acute inflammatory response induced by carrageenin (1 ..
  4. pmc Differential changes of adrenoceptor- and muscarinic receptor-linked prostacyclin synthesis by the aorta and urinary bladder of the diabetic rat
    J Y Jeremy
    Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, University of London
    Br J Pharmacol 108:1131-6. 1993
    ..PKC]), Ca2+ ionophore A23187 (A23187) and thapsigargin (both elevate intracellular Ca2+, activating phospholipase A2 [PLA2]) and arachidonate (AA; substrate for PGI2 synthesis). 2...
  5. pmc Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carrageenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2
    A Miyake
    Molecular and Cellular Pharmacology, Dept, Yamanouchi Pharmaceutical Co Ltd, Tokyo, Japan
    Br J Pharmacol 110:447-53. 1993
    ..eny l) chroman] dose-dependently inhibited the activities of extracellular phospholipase A2 (PLA2): rabbit platelet-derived group II and porcine pancreas-derived group I PLA2, with IC50 values of 0...
  6. ncbi Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI
    D W Snyder
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 288:1117-24. 1999
    LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, LY315920 inhibited sPLA2 activity with an IC50 of 9 +/- 1 nM or 7...
  7. pmc Up-regulation of [3H]-des-Arg10-kallidin binding to the bradykinin B1 receptor by interleukin-1 beta in isolated smooth muscle cells: correlation with B1 agonist-induced PGI2 production
    J P Galizzi
    Cerep, Celle l evescault, France
    Br J Pharmacol 113:389-94. 1994
    ..This observation suggests that IL-1 but not LPS, in addition to increase in the number of receptors, signals the cell to permit the coupling of B1 receptors to the PLA2/cyclo-oxygenase pathway.
  8. ncbi Intracerebral injection of phospholipase A2 inhibits dopamine-mediated behavior in rats: possible implications for schizophrenia
    J Brunner
    Neurobiology Unit, Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 246:13-6. 1995
    b>Phospholipase A2 (PLA2) is a key enzyme in the phospholipid metabolism. In the CNS intracellular PLA2 plays an essential role in signal transduction by affecting both dopamine (DA) release and DA-receptor sensitivity...
  9. ncbi Pancreatic phospholipase A2--mediated enhancement of the respiratory burst response of human neutrophils
    J Muller
    Institute of Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Germany
    Z Naturforsch C 56:1150-6. 2001
    The aim of this study was to investigate the effects of exogenously added pancreatic phospholipase A2 (pPLA2) on the production of reactive oxygen species by human polymorphonuclear leukocytes (PMNs)...
  10. ncbi Affinity purification of phospholipase A2 on immobilized artificial membranes containing and lacking the glycerol backbone
    C Bernal
    Department of Medicinal Chemistry, School of Pharmacy, Perdue University, West Lafayette, IN 47907, USA
    J Chromatogr A 731:139-51. 1996
    ..of PLA2 on these IAM surfaces demonstrated that the surface structural differences were not important for phospholipase A2 (PLA2) binding...
  11. ncbi Arachidonic acid induces c-jun gene expression in stromal cells stimulated by interleukin-1 and tumor necrosis factor-alpha: evidence for a tyrosine-kinase-dependent process
    M T Rizzo
    Division of Hematology and Bone Marrow Transplantation, Parma University School of Medicine, Italy
    Blood 86:2967-75. 1995
    ..1-LDA 11 involves activation of phospholipase A2 (PLA2)...
  12. ncbi Decreased phospholipase A2 activity in the brain and in platelets of patients with Alzheimer's disease
    W F Gattaz
    Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 246:129-31. 1996
    b>Phospholipase A2 (PLA2) is a key enzyme in the metabolism of membrane phospholipids...
  13. ncbi Effect of neuroleptics on phospholipase A2 activity in the brain of rats
    H I Trzeciak
    Department of Pharmacology, Silesian Academy of Medicine, Katowice-Ligota, Poland
    Eur Arch Psychiatry Clin Neurosci 245:179-82. 1995
    The effect of neuroleptics on phospholipase A2 (PLA2) activity in rat brain plasma membranes was studied...
  14. ncbi Effect of a new inhibitor of type II phospholipase A2 on experimental acute pancreatitis in rats
    T Yoshikawa
    Department of Internal Medicine II, Nagoya University School of Medicine, Japan
    Pancreas 19:193-8. 1999
    The catalytic activity of type II phospholipase A2 (PLA2) in blood has been reported to increase in acute pancreatitis and to reflect the severity of pancreatitis...
  15. doi Purification, characterization and bactericidal activities of basic phospholipase A2 from the venom of Agkistrodon halys (Chinese pallas)
    R Perumal Samy
    Venom and Toxin Research Programme, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Biochimie 90:1372-88. 2008
    Agkistrodon snake venoms contain a variety of phospholipases (PLA2), some of which are myotoxic. In this study, we used reverse-phase HPLC to purify PLA2 from the venom of Agkistrodon halys...
  16. pmc Distinct phospholipase A2 enzymes regulate prostaglandin E2 and F2alpha production by bovine endometrial epithelial cells
    Patricia K Tithof
    The University of Tennessee College of Veterinary Medicine, TN, USA
    Reprod Biol Endocrinol 5:16. 2007
    The rate-limiting step in prostaglandin (PG) biosynthesis is catalyzed by phospholipase A2 (PLA2) enzymes which hydrolyze arachidonic acid from membrane phospholipids...
  17. pmc Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation
    Barry M Markaverich
    Department of Molecular and Cellular Biology, Baylor Colloege of Medicine, Houston, TX 77030, USA
    Environ Health Perspect 115:1727-31. 2007
    ..Synthetic THF-diols inhibited rat male and female sexual behavior at oral concentrations of 0.5-1 ppm, and stimulated MCF-7 human breast cancer cell proliferation in vitro...
  18. ncbi Semisynthetic preparation of 1-O-hexadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor)
    M E Lekka
    Department of Chemistry, University of Ioannina, Greece
    Z Naturforsch C 43:665-70. 1988
    ..the chromatographic behaviour on TLC and HPLC, the physicochemical properties and the behaviour under treatment with PLA2 and Lipase from Rhizopus arrhizus. The above procedure is proposed as a facile, inexpensive and convenient method.
  19. pmc Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin production
    James D Godkin
    Department of Animal Science, The University of Tennessee, Knoxville, TN, USA
    Reprod Biol Endocrinol 6:44. 2008
    ..b>Phospholipase A2 (PLA2) catalyzes the release of arachidonic acid from membrane phospholipids, the rate-limiting step in PG ..
  20. ncbi Chymopapain-induced reduction of proinflammatory phospholipase A2 activity and amelioration of neuropathic behavioral changes in an in vivo model of acute sciatica
    P D Sawin
    Department of Pathology, The University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    J Neurosurg 86:998-1006. 1997
    ..the authors assessed the ability of chymopapain to modulate the activity of the proinflammatory enzyme phospholipase A2 (PLA2) and to ameliorate behavioral changes associated with inflammatory neuropathy in an in vivo model of ..
  21. ncbi Oxalate toxicity in renal cells
    Julie A Jonassen
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Urol Res 33:329-39. 2005
    ..Oxalate exposure activates phospholipase A2 (PLA2), which increases two lipid signaling molecules, arachidonic acid and lysophosphatidylcholine (Lyso-PC)...
  22. pmc Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2
    Ji Fu Wei
    Clinical Experiment Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China
    BMC Immunol 10:21. 2009
    It has been recognized that phospholipase A2 (PLA2) is a crucial component of snake venom, which contributes greatly to snake venom induced inflammation in man...
  23. ncbi Mobile phase effects on membrane protein elution during immobilized artificial membrane chromatography
    C Pidgeon
    Department of Medicinal Chemistry, School of Pharmacy, Purdue University, West Layfayette, IN 47907, USA
    J Chromatogr A 721:213-30. 1996
    ..Two protein mixtures containing bovine pancreatic PLA2 were used in this study...
  24. ncbi Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Free Radic Biol Med 40:364-75. 2006
    ..Several lines of evidence point to the combined action of phospholipase A2 and cytochrome P450 as central in the mechanism of cellular injury in several human diseases, such as ..
  25. ncbi Phospholipase A2 is present in meconium and inhibits the activity of pulmonary surfactant: an in vitro study
    A J Schrama
    Department of Pediatrics, Leiden University Medical Center, The Netherlands
    Acta Paediatr 90:412-6. 2001
    ..g. fatty acids, inhibit surfactant activity. However, the role of the enzyme phospholipase A2 (PLA2), which hydrolyses surfactant in adult respiratory distress syndrome (ARDS), has not yet been studied...
  26. ncbi Prostaglandin release from lumbar disc and facet joint tissue
    R E Willburger
    Department of Orthopaedic Surgery, Ruhr University, Bochum, Germany
    Spine (Phila Pa 1976) 19:2068-70. 1994
    ..SUMMARY OF BACKGROUND DATA. High levels of phospholipase A2 (PLA2) have been measured in the human disc. PLA2 releases fatty acids from lipid membranes...
  27. ncbi Inhibition of phospholipase A2 (PLA2) activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity
    J Chang
    Department of Experimental Therapeutics, Wyeth Laboratories, Inc, Philadelphia, Pennsylvania 19101
    Inflammation 11:353-64. 1987
    The effects of several calcium antagonists on phospholipase A2 (PLA2) activity were examined...
  28. ncbi Ca2+-independent phospholipase A2 contributes to the insulinotropic action of cholecystokinin-8 in rat islets: dissociation from the mechanism of carbachol
    E Simonsson
    Department of Medicine, Lund University, Malmo, Sweden
    Diabetes 47:1436-43. 1998
    Insulin secretion induced by cholecystokinin-8 (CCK-8) was recently suggested to involve phospholipase A2 (PLA2) activation...
  29. ncbi Role of various phospholipases A2 and inhibitors in the pathogenesis and prevention of pancreatic acinar cell necrosis: studies with isolated rat pancreatic acini
    J MOssner
    Department of Internal Medicine II, University of Leipzig, Germany
    Int J Pancreatol 27:29-38. 2000
    b>Phospholipase A2 (PLA2) may play a central role in the pathogenesis of pancreatic acinar cell necrosis...
  30. ncbi Purification, characterization, and molecular cloning of group I phospholipases A2 from the gills of the red sea bream, Pagrus major
    N Iijima
    Faculty of Applied Biological Science, Hiroshima University, Higashihiroshima, Japan
    Lipids 35:1359-70. 2000
    b>Phospholipase A2 (PLA2) activity was investigated in various tissues of male and female red sea bream...
  31. doi CC-PLA2-1 and CC-PLA2-2, two Cerastes cerastes venom-derived phospholipases A2, inhibit angiogenesis both in vitro and in vivo
    Raoudha Kessentini-Zouari
    Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Tunis, Tunisia
    Lab Invest 90:510-9. 2010
    ..Here, we report that CC-PLA2-1 and CC-PLA2-2, two novel secreted phospholipases A(2) (PLA(2)) isolated from Cerastes cerastes venom, also showed ..
  32. ncbi Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2
    E C Landucci
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil
    Toxicon 38:199-208. 2000
    The effects of crotapotin (a non-toxic and non-enzymatic acid polypeptide naturally complexed with phospholipase A2) and heparin on rat paw edema induced by different secretory phospholipases A2 (sPLA2) have been investigated...
  33. ncbi Binding of quinacrine to acidic phospholipids and pancreatic phospholipase A2. Effects on the catalytic activity of the enzyme
    P Mustonen
    Institute of Biomedicine, Department of Medical Chemistry, University of Helsinki, Finland
    Biochemistry 37:12051-7. 1998
    Binding of quinacrine to phospholipids and porcine pancreatic phospholipase A2 (PLA2) was investigated using fluorescence resonance energy transfer, Langmuir films, assay for the enzymatic activity, and molecular modeling...
  34. ncbi Thiol-oxidizing agent diamide and acidic pH enhance lipid peroxidation of rat heart mitochondria and cardiolipin-cytochrome c complex
    H Iwase
    Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, Japan
    IUBMB Life 51:39-43. 2001
    In this study, we investigated lipid peroxidation in rat heart mitochondria hydrolyzed by phospholipase A2 (PLA2) and lipid peroxidation in a mitochondrial-mimetic lipid peroxidation system, where phospholipids such as cardiolipin (CL) ..
  35. pmc Modulation of the pharmacological effects of enzymatically-active PLA2 by BTL-2, an isolectin isolated from the Bryothamnion triquetrum red alga
    Simone Cb Oliveira
    Biochemistry Department, Biology Institute, UNICAMP, Campinas, Sao Paulo, Brazil
    BMC Biochem 9:16. 2008
    An interaction between lectins from marine algae and PLA2 from rattlesnake was suggested some years ago...
  36. ncbi Lysophospholipid regulates release and activation of latent TGF-beta1 from chondrocyte extracellular matrix
    I Gay
    University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Biochim Biophys Acta 1684:18-28. 2004
    ..is released from these extracellular organelles by the direct action of 1alpha,25(OH)2D3 via activation of phospholipase A2 (PLA2), resulting in local production of lysophospholipids and matrix vesicle membrane destabilization...
  37. ncbi CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792 3232, USA
    J Biol Chem 281:6718-25. 2006
    ..PtdCho homeostasis is regulated by the balance between hydrolysis and synthesis. PtdCho is hydrolyzed by phospholipase A2 (PLA2), PtdChospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD)...
  38. ncbi Porcine pancreatic phospholipase A2 stimulates secretin release from secretin-producing cells
    T M Chang
    Konar Center for Digestive and Liver Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 274:10758-64. 1999
    ..14-kDa proteins with secretin-releasing activity that had N-terminal sequence homology with canine pancreatic phospholipase A2 (PLA2)...
  39. ncbi Phospholipase A2 in cnidaria
    Timo J Nevalainen
    Department of Pathology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Comp Biochem Physiol B Biochem Mol Biol 139:731-5. 2004
    b>Phospholipase A2 (PLA2) is an enzyme present in snake and other venoms and body fluids...
  40. pmc Crystal structure of a class XIB phospholipase A2 (PLA2): rice (oryza sativa) isoform-2 pla2 and an octanoate complex
    Jodie E Guy
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm S 17177, Sweden
    J Biol Chem 284:19371-9. 2009
    ..Due to the differences in structure, the suggested surface for binding to the membrane has a different morphology in the rice PLA(2) compared with other phospholipases...
  41. ncbi Cyclic stretch-induced cPLA2 mediates ERK 1/2 signaling in rabbit proximal tubule cells
    Larry D Alexander
    Department of Medicine, Division of Nephrology and Hypertension, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106 4982, USA
    Kidney Int 65:551-63. 2004
    Recent evidence from this laboratory have demonstrated a critical role of phospholipase A2 (PLA2) and arachidonic acid in angiotensin II type 2 (AT2) receptor-mediated kinase activation in renal epithelium independent of phosphoinositide- ..
  42. ncbi Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachido
    Won K Han
    Medical Services, Massachusetts General Hospital, Department of Medicine and Anesthesia, Harvard Medical School, Massachusetts, USA
    J Biol Chem 278:24153-63. 2003
    Oxidant stress and phospholipase A2 (PLA2) activation have been implicated in numerous proinflammatory responses of the mesangial cell (MC)...
  43. ncbi Effects of scalaradial, a type II phospholipase A2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation
    L A Marshall
    Department of Inflammation and Respiratory Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania
    J Pharmacol Exp Ther 268:709-17. 1994
    ..SLD potently inhibited human recombinant (rh) type II-14 kDa-phospholipase A2 (PLA2) (IC50 = 0.07 microM) but displayed weak inhibition of U937 cell, 85 kDa-PLA2 (IC50 = 20 microM)...
  44. doi The role of lipoprotein-associated phospholipase A2 in atherosclerosis may depend on its lipoprotein carrier in plasma
    Constantinos C Tellis
    Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
    Biochim Biophys Acta 1791:327-38. 2009
    Platelet-activating factor (PAF) acetylhydrolase exhibits a Ca(2+)-independent phospholipase A2 activity and degrades PAFas well as oxidized phospholipids (oxPL)...
  45. ncbi Role of an aprotinin-sensitive protease in protein kinase Calpha-mediated activation of cytosolic phospholipase A2 by calcium ionophore (A23187) in pulmonary endothelium
    Sajal Chakraborti
    Department of Biochemistry and Biophysics, University of Kalyani, Kalyani 741235, West Bengal, India
    Cell Signal 16:751-62. 2004
    ..cells with the calcium ionophore, A23187, stimulates the cell membrane associated protease activity, phospholipase A2 (PLA2) activity, and arachidonic acid (AA) release from the cells...
  46. ncbi Synergistic effect of type II phospholipase A2 and platelet-activating factor on Mac-1 surface expression and exocytosis of gelatinase granules in human neutrophils: evidence for the 5-lipoxygenase-dependent mechanism
    J Takasaki
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Tsukuba, Ibaraki, Japan
    J Immunol 160:5066-72. 1998
    ..Type II phospholipase A2 (PLA2-II) also induces translocation of Mac-1 from secretory vesicles...
  47. pmc Role of arachidonic acid and its metabolites in the priming of NADPH oxidase in human polymorphonuclear leukocytes by peritoneal dialysis effluent
    I Daniels
    Medical Research Centre, City Hospital, Nottingham, United Kingdom
    Clin Diagn Lab Immunol 5:683-9. 1998
    ..a low-molecular-weight solute that will activate and prime the NADPH oxidase of human neutrophils via a phospholipase A2 (PLA2)-dependent mechanism...
  48. ncbi Human neutrophil migration in vitro induced by secretory phospholipases A2: a role for cell surface glycosaminoglycans
    Alessandra Gambero
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, PO Box 6111, 13081 970, Campinas, SP, Brazil
    Biochem Pharmacol 63:65-72. 2002
    ..Piratoxin-I, bothropstoxin-I, N. m. mocambique venom PLA2 (10-1000 microg/mL each), bothropstoxin-II (30-1000 microg/mL), porcine pancreas PLA2 (0.3-30 microg/mL), and A...
  49. ncbi PLA2 mediated arachidonate free radicals: PLA2 inhibition and neutralization of free radicals by anti-oxidants--a new role as anti-inflammatory molecule
    B L Nanda
    Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India
    Curr Top Med Chem 7:765-77. 2007
    b>PLA2 enzyme catalyses the hydrolysis of cellular phospholipids at the sn-2 position to liberate arachidonic acid and lysophospholipid to generate a family of pro-inflammatory eicosanoids and platelet activating factor...
  50. ncbi Lipoprotein-associated phospholipase A2 for early risk stratification in patients with suspected acute coronary syndrome: a multi-marker approach: the North Wuerttemberg and Berlin Infarction Study-II (NOBIS-II)
    M Mockel
    Dept of Cardiology, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Clin Res Cardiol 96:604-12. 2007
    ..of the present study was to define the role of the emerging cardiovascular risk marker lipoprotein-associated phospholipase A2 (Lp-PLA2) in a multi-marker approach in combination with troponin I (TnI), NT-proBNP, high sensitivity (hs)..
  51. ncbi Phospholipases in biology and medicine
    E Kaiser
    Department of Medical Chemistry, University of Vienna, Austria
    Clin Biochem 23:349-70. 1990
    ..1.1.3), PLA2 (EC 3.1.1.4), PLB (EC 3.1.1.5), PLC (EC 3.1.4.3), and PLD (EC 3.1.4.4)...
  52. pmc Ectopic expression of Arabidopsis phospholipase A genes elucidates role of phospholipase Bs in S. cerevisiae cells
    Meng Zhang
    National Research Council of Canada, Plant Biotechnology Institute, 110 Gymnasium Place, Saskatoon, SK, S7N 0W9, Canada
    Open Microbiol J 3:136-45. 2009
    ..To test our hypothesis, we overexpressed a plant phospholipase A2 (PLA2) in both WT and plb123 cells, producing a pool of lysophosphatidylcholine (lysoPtdCho) in both ..
  53. ncbi Anti-masculinizing action of estradiol and cyproterone acetate: regulation of a protein fraction with phospholipase-A2 stimulatory and masculinizing activities
    C Gupta
    Department of Pediatric Nephrology, Children s Hospital of Pittsburgh, School of Medicine, University of Pittsburgh, PA 15213
    J Steroid Biochem Mol Biol 37:661-7. 1990
    ..a protein fraction (55-63 K) from male and testosterone-exposed female mouse genital tract, which stimulates phospholipase A2 (PLA2) and induces masculine differentiation in an undifferentiated mouse genital explant, suggesting a role ..
  54. pmc Fusion of neurotransmitter vesicles with target membrane is calcium independent in a cell-free system
    U O Karli
    Friedrich Miescher Institut, Basel, Switzerland
    Proc Natl Acad Sci U S A 87:5912-5. 1990
    ..this fusion in vitro by using chromaffin granules (CGs) and target membrane vesicles and a Ca2(+)-dependent phospholipase A2 (PLA2)...
  55. ncbi Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein
    T S Kim
    University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Biol Chem 272:2542-50. 1997
    A Ca2+-independent phospholipase A2 (PLA2) maximally active at pH 4 and specifically inhibited by the transition-state analogue 1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol (MJ33) was isolated from rat lungs...
  56. ncbi Low and high density lipoprotein--cholesterol and coronary atherothrombosis
    Vladimir Kanjuh
    Cardiovascular Pathology, University School of Medicine Postgraduate, 11000 Belgrade, Dobracina 12
    Med Pregl 62:7-14. 2009
    ..Edwards and R. Virmani), the authors described the P. Libby's data on lipoprotein-associated phospholipaseA2 (Lp-PLA2) and its two inflammatory mediators: lysophosphatidylcholine and oxidized nonesterified fatty acids...
  57. ncbi Biochemical and enzymatic characterization of two basic Asp49 phospholipase A2 isoforms from Lachesis muta muta (Surucucu) venom
    Daniela C S Damico
    Department of Biochemistry, Institute of Biology, State University of Campinas UNICAMP, Campinas, SP, Brazil
    Biochim Biophys Acta 1726:75-86. 2005
    Two basic phospholipase A2 (PLA2) isoforms were isolated from Lachesis muta muta snake venom and partially characterized...
  58. ncbi Effects of long-term ursodeoxycholate administration on expression levels of secretory low-molecular-weight phospholipases A2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones
    M Kano
    Department of Gastroenterology, Institute of Clinical Medicine, The University of Tsukuba, Ibaraki, Japan
    Hepatology 28:302-13. 1998
    Group IIA phospholipase A2 (PLA2), a secretory low-molecular-weight PLA2, may play a critical role in the process of gallbladder mucosal inflammation in multiple cholesterol stones, which in turn may produce biliary pronucleating proteins ..
  59. ncbi The structural variations of epsilon-amino groups in phospholipase A2 enzymes from Naja naja atra and Bungarus multicinctus venoms
    L S Chang
    Department of Biochemistry, Kaohsiung Medical College, Taiwan, ROC
    J Protein Chem 16:133-7. 1997
    Comparative studies on Naja naja atra phospholipase A2 (NNA-PLA2), Bungarus multicinctus phospholipase A2 (BM-PLA2), and their Lys-modified derivatives were made to assess the differences in the fine structures around the conserved Lys ..
  60. ncbi Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:33866-77. 2003
    Previous studies suggested a role for calcium in CYP2E1-dependent toxicity. The possible role of phospholipase A2 (PLA2) activation in this toxicity was investigated...
  61. ncbi An update on inhibitors of human 14 kDa Type II s-PLA2 in development
    D M Springer
    Anti infective Chemistry, Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, P O Box 5100, Wallingford, CT 06492, USA
    Curr Pharm Des 7:181-98. 2001
    Recent progress in the development of inhibitors of human Type II s-PLA2 as potential anti-inflammatory agents is presented...
  62. ncbi A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP
    J D Clark
    Genetics Institute, Inc, Cambridge, Massachusetts 02140
    Cell 65:1043-51. 1991
    We report the cloning and expression of a cDNA encoding a high molecular weight (85.2 kd) cytosolic phospholipase A2 (cPLA2) that has no detectable sequence homology with the secreted forms of PLA2...
  63. pmc A simple and sensitive method for determining transcription initiation site: identification of two transcription initiation sites in rat group II phospholipase A2 gene
    O Ohara
    Shionogi Research Laboratories, Shionogi and Co Ltd, Osaka, Japan
    Nucleic Acids Res 18:6997-7002. 1990
    ..transcriptional initiation sites, and applied it to characterize the transcriptional unit of rat group II phospholipase A2 (PLA2) gene...
  64. ncbi Cloning and expression of phospholipase A2 from guinea pig gastric mucosa, its induction by carbachol and secretion in vivo
    Z Ying
    Department of Molecular Physiological Chemistry, Osaka University Medical School, Japan
    Eur J Biochem 215:91-7. 1993
    A cDNA encoding phospholipase A2 (PLA2) was cloned from guinea pig gastric mucosa using a rat pancreatic-PLA2-cDNA fragment as a probe...
  65. pmc Liver cirrhosis induces renal and liver phospholipase A2 activity in rats
    B S Vishwanath
    Division of Nephrology, Department of Medicine, University of Berne, Switzerland
    J Clin Invest 98:365-71. 1996
    ..of the present study was to establish whether the first enzyme of the prostaglandin cascade synthesis, the phospholipase A2(PLA2) is altered in liver cirrhosis induced by bile duct excision...
  66. pmc Resistance of transgenic mice expressing human group II phospholipase A2 to Escherichia coli infection
    V J Laine
    Department of Pathology, University of Turku, 20520 Turku, Finland
    Infect Immun 68:87-92. 2000
    Group II phospholipase A2 (PLA2) is a newly recognized antibacterial acute-phase protein...
  67. ncbi Prostaglandin levels in stimulated macrophages are controlled by phospholipase A2-activating protein and by activation of phospholipase C and D
    D A Ribardo
    Department of Microbiology and Immunology and Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1070, USA
    J Biol Chem 276:5467-75. 2001
    ..We demonstrated that PG levels in cells were partly controlled by a regulatory protein, phospholipase A2 (PLA2)-activating protein (PLAA)...
  68. ncbi Fatty acids inhibit anion secretion in rat colon: apical and basolateral action sites
    G Schultheiss
    Institut für Veterinär Physiologie, Justus Liebig Universitat Giessen, Germany
    Pflugers Arch 442:603-13. 2001
    ..However, inhibition of phospholipases A2 (PLA2) by quinacrine or arachidonyltrifluoromethyl ketone (AACOCF3) enhanced the Isc response evoked by carbachol, ..
  69. ncbi Inhibition of Naja nigricolis venom acidic phospholipase A2 catalysed hydrolysis of ghost red blood cells by columbin
    A J Nok
    J Enzyme Inhib Med Chem 17:55-9. 2002
    ..inhibitory effects of a naturally occurring diterpenoid furanolactone, columbin, on partially purified acidic phospholipase A2 (PLA2) from Naja nigricolis was investigated. Columbin inhibited the N...
  70. ncbi Interaction of low molecular weight group IIA phospholipase A2 with apoptotic human T cells: role of heparan sulfate proteoglycans
    Eric Boilard
    Pilot Therapeutics Inc, 2000 Daniel Island Dr, Suite 440, Charleston, SC 29492, USA
    FASEB J 17:1068-80. 2003
    Human group IIA phospholipase A2 (hIIA PLA2) is a 14 kDa secreted enzyme associated with inflammatory diseases. A newly discovered property of hIIA PLA2 is the binding affinity for the heparan sulfate proteoglycan (HSPG) glypican-1...
  71. ncbi Phospholipid hydroperoxides are detoxified by phospholipase A2 and GSH peroxidase in rat gastric mucosa
    Sayuri Miyamoto
    Department of Nutrition, School of Medicine, The University of Tokushima, Tokushima 770 8503, Japan
    Lipids 38:641-9. 2003
    ..reduced linoleic acid hydroperoxides (LAOOH) and lysophosphatidylcholine, indicating the involvement of phospholipase A2 (PLA2) in the elimination pathway...
  72. ncbi Xenorhabdus nematophilus inhibits p-bromophenacyl bromide (BPB)-sensitive PLA2 of Spodoptera exigua
    Youngjin Park
    School of Bioresource Sciences, College of Natural Sciences, Andong National University, Andong, Korea
    Arch Insect Biochem Physiol 54:134-42. 2003
    ..This study focused on the inhibitory effect of X. nematophilus on PLA2 activity of Spodoptera exigua...
  73. ncbi Inhibition of nitric-oxide synthase-I (NOS-I)-dependent nitric oxide production by lipopolysaccharide plus interferon-gamma is mediated by arachidonic acid. Effects on NFkappaB activation and late inducible NOS expression
    Letizia Palomba
    Istituto di Farmacologia e Farmacognosia, Universita di Urbino Carlo Bo, Via S Chiara 27, 61029 Urbino, Italy
    J Biol Chem 279:29895-901. 2004
    ..This notion was established using pharmacological inhibitors of phospholipase A2 (PLA2), cytosolic PLA2 (cPLA2) antisense oligonucleotides, and AA add-back experiments...
  74. ncbi 1alpha,25(OH)2D3 and parathyroid hormone (PTH) signaling in rat intestinal cells: activation of cytosolic PLA2
    Claudia Gentili
    Department of Biologia, Bioquimica and Farmacia, Universidad Nacional del Sur, San Juan 670, Bahia Blanca 8000, Argentina
    J Steroid Biochem Mol Biol 89:297-301. 2004
    In the current study, we have probed the role of cytosolic phospholipase A2 (cPLA2) activity in the cellular response to the calciotropic hormones, 1alpha,25,dihydroxy-vitamin D(3) [1alpha,25(OH)(2)D(3)] and PTH...
  75. ncbi Reorganization of lipid nanocapsules at air-water interface 3. Action of hydrolytic enzymes HLL and pancreatic PLA2
    I Minkov
    Biophysical Chemistry Laboratory, University of Sofia, J Bourchier Str 1, 1126 Sofia, Bulgaria
    Colloids Surf B Biointerfaces 45:24-34. 2005
    The action of the hydrolytic enzymes humicola lanuginosa lipase (HLL) and pancreatic phospholipase A2 (PLA2) on monolayers formed from lipid nanocapsules (LNC) and model monolayers containing their components, Labrafac, Solutol and Lipoid,..
  76. ncbi Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer
    Karam El-Bayoumy
    Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Carcinogenesis 27:1369-76. 2006
    ..Using western blot analysis, we showed that p-XSC reduced the expression of cyclooxygenase-2 (COX-2) and phospholipase A2 (PLA2); although p-XSC inhibited both Akt and p-Akt but its effect was not significant...
  77. ncbi Pancreatic phospholipase A2 contributes to lung injury in experimental meconium aspiration
    Tomi Sippola
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Pediatr Res 59:641-5. 2006
    To investigate the role of pancreatic (group I) secretory PLA2 (sPLA2-I) in the pathogenesis of meconium aspiration syndrome, human particulate meconium or its supernatant either before or after extraction of PLA2-I was insufflated into ..
  78. doi Cytotoxicity and antimicrobial activity of the methanol extract and compounds from Polygonum limbatum
    Jean P Dzoyem
    Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
    Planta Med 78:787-92. 2012
    ..MIC values were noted on 100 % of the 11 tested microorganisms for fraction PLA3, 72.7 % for PLA, fraction PLA2, and compound 4, 63.6 % for PLA1, and 54.5 % for fraction PLA4...
  79. doi Evidence supporting a key role of Lp-PLA2-generated lysophosphatidylcholine in human atherosclerotic plaque inflammation
    Isabel Goncalves
    Experimental Cardiovascular Research Group, Clinical Research Center, Clinical Sciences, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 32:1505-12. 2012
    To determine whether the level of lysophosphatidylcholine (lysoPC) generated by lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with severity of inflammation in human atherosclerotic plaques...
  80. doi Diverse regulation of retinal pigment epithelium phagocytosis of photoreceptor outer segments by calcium-independent phospholipase A₂, group VIA and secretory phospholipase A₂, group IB
    Chen Zhan
    Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej, Copenhagen, Denmark
    Curr Eye Res 37:930-40. 2012
    ....
  81. pmc Inhibition of toxic actions of phospholipase A2 isolated & characterized from the Indian Banded Krait (Bungarus fasciatus) venom by synthetic herbal compounds
    Antony Gomes
    Department of Physiology, University of Calcutta, Kolkata, India
    Indian J Med Res 136:40-5. 2012
    b>Phospholipase A2 (PLA2 ) is one of the major constituents of krait venom associated with several pathophysiological actions like myotoxicity, cardiotoxicity, neurotoxicity, etc...
  82. doi Action of two phospholipases A2 purified from Bothrops alternatus snake venom on macrophages
    S S Setúbal
    Laboratório de Bioquímica e Biotecnologia e Laboratório de Cultivo Celular e Anticorpos Monoclonais, Instituto de Pesquisas em Patologias Tropicais, Porto Velho, Rondonia, CEP 76812 245, Brazil
    Biochemistry (Mosc) 78:194-203. 2013
    The in vitro effects of BaltTX-I, a catalytically inactive Lys49 variant of phospholipase A2 (PLA2), and BaltTX-II, an Asp49 catalytically active PLA2 isolated from Bothrops alternatus snake venom, on thioglycollate-elicited macrophages (..
  83. pmc Lysophosphatidylcholine and carotid intima-media thickness in young smokers: a role for oxidized LDL-induced expression of PBMC lipoprotein-associated phospholipase A2?
    Anna Fratta Pasini
    Section of Internal Medicine D, Department of Medicine, University of Verona, Verona, Italy
    PLoS ONE 8:e83092. 2013
    ..Lysophosphatidylcholine (lysoPC), a main product of lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, appears to be a major determinant of the pro-atherogenic properties of oxidized LDL (..
  84. doi Neurotoxicity of coral snake phospholipases A2 in cultured rat hippocampal neurons
    Nathalia Delazeri de Carvalho
    Laboratory of Pharmacology, Butantan Institute, Av Dr Vital Brasil 1500, Sao Paulo, SP 05503 900, Brazil
    Brain Res 1552:1-16. 2014
    ..debris and membrane fragmentation were observed mainly when the cells were exposed to highest concentration of the PLA2-neurotoxins...
  85. doi Combined venom gland cDNA sequencing and venomics of the New Guinea small-eyed snake, Micropechis ikaheka
    Owen Paiva
    School of Medicine and Health Sciences, University of Papua New Guinea, Boroko, NCD, Papua New Guinea
    J Proteomics 110:209-29. 2014
    ..ikaheka and Australian elapid venoms may underlay the positive clinical outcomes of envenoming resulting from bites by M. ikaheka that have been documented through the use of bioCSL polyvalent antivenom...
  86. doi Chronic inhibition of brain phospholipase A2 in adult rats impairs the survival of newborn mature neurons in the hippocampus
    Evelin L Schaeffer
    Department and Institute of Psychiatry, Laboratory of Neuroscience LIM 27, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, Sao Paulo, 05403 010, Brazil
    J Neural Transm (Vienna) 122:619-28. 2015
    ..In vitro studies suggest a role for phospholipase A2 (PLA2) in neuronal differentiation/maturation and survival...
  87. ncbi Inhibition of cPLA2 has neuroprotective effects on motoneuron and muscle atrophy following spinal cord injury
    Nai Kui Liu
    Indiana University, Neurological Surgery, Indianapolis, Indiana, United States
    J Neurotrauma . 2014
    ..Our previous studies showed that phospholipase A2 (PLA2) may play an important role in the pathogenesis of SCI...
  88. pmc Phylogenetic and structural analysis of the phospholipase A2 gene family in vertebrates
    Qi Huang
    Department of Neurology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, P R China
    Int J Mol Med 35:587-96. 2015
    ..However, the phylogenetic background of the PLA2 gene family and the amino acid residues of the PLA2G7 gene following positive selection gene remain undetermined...
  89. doi Unveiling the complexities of Daboia russelii venom, a medically important snake of India, by tandem mass spectrometry
    Maitreyee Sharma
    Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur 784 028, Assam, India
    Toxicon 107:266-81. 2015
    ..b>Phospholipase A2 (PLA2), serine proteases, metalloproteases, cysteine-rich secretory proteins, l-amino acid oxidase, C-type ..
  90. pmc Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages
    Shun He
    From the Center for Systems Biology, Massachusetts General Hospital, Boston S H, B G C, A F, A A, M N, I H, Y S, Y X Y, Y I, B T, R W, M N, F K S Biological Sciences, GlaxoSmithKline, Collegeville, PA M B Department of Systems Biology, Harvard Medical School, Boston, MA R W GlaxoSmithKline, King of Prussia, PA C M Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA P L
    Circ Heart Fail 8:980-7. 2015
    ..Lipoprotein-associated phospholipase A2 (Lp-PLA2), a member of the phospholipase A2 family of enzymes, produced predominantly by leukocytes, ..
  91. doi l-amino acid oxidase from Bothrops marajoensis causes nephrotoxicity in isolated perfused kidney and cytotoxicity in MDCK renal cells
    Rodrigo Tavares Dantas
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil
    Toxicon 104:52-6. 2015
    ..Previously, we studied the renal effect of the whole venom of Bothrops marajoensis and its phospholipase A2 (PLA2), but these effects could not to be attributed to PLA2...
  92. doi The importance of being genomic: Non-coding and coding sequences suggest different models of toxin multi-gene family evolution
    Anita Malhotra
    School of Biological Sciences, College of Natural Sciences, Bangor University, Bangor LL57 2UW, UK Electronic address
    Toxicon 107:344-58. 2015
    ..We illustrate this using snake venom gene sequences from the Phospholipase A2 (PLA2) subfamily...
  93. doi Anti-parasitic effect on Toxoplasma gondii induced by BnSP-7, a Lys49-phospholipase A2 homologue from Bothrops pauloensis venom
    Isabela Pacheco Borges
    Laboratório de Bioquímica e Toxinas Animais, Instituto de Genética e Bioquímica, Universidade Federal de Uberlandia, UFU, Uberlandia, MG, Brazil
    Toxicon 119:84-91. 2016
    ..Herein, we report the antiparasitic effects of BnSP-7 toxin, a Lys49 phospholipase A2 (PLA2) homologue from Bothrops pauloensis snake venom, on Toxoplasma gondii...
  94. pmc Biosynthesis of oxidized lipid mediators via lipoprotein-associated phospholipase A2 hydrolysis of extracellular cardiolipin induces endothelial toxicity
    Justin R Buland
    Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Vascular Medicine Institute, Pittsburgh, Pennsylvania
    Am J Physiol Lung Cell Mol Physiol 311:L303-16. 2016
    ..cardiolipin (CL), followed by hydrolysis [by calcium-independent mitochondrial calcium-independent phospholipase A2-γ (iPLA2γ)] of oxidized CL (CLox), leading to the formation of lysoCL and oxygenated octadecadienoic ..
  95. doi Lp-PLA2 silencing protects against ox-LDL-induced oxidative stress and cell apoptosis via Akt/mTOR signaling pathway in human THP1 macrophages
    Huadong Zheng
    Department of Geriatrics, The Second Affiliated Hospital, Xi an Jiaotong University Health Science Center, Xi an 710004, Shaanxi, PR China Laboratory Animal Center, Xi an Jiaotong University Health Science Center, Xi an 710061, Shaanxi, PR China Electronic address
    Biochem Biophys Res Commun 477:1017-23. 2016
    ..In this study, we investigated the role of lipoprotein-associated phospholipase A2 (Lp-PLA2) in ox-LDL-induced oxidative stress and cell apoptosis, and further, elucidated the potential ..
  96. ncbi Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity
    P K Larsson
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Biol Chem 273:207-14. 1998
    Recently, the cloning of a novel Ca2+-independent phospholipase A2 (iPLA2) from Chinese hamster ovary cells as well as from mouse and rat sources containing a C-terminal lipase motif and eight N-terminal ankyrin repeats has been described...
  97. ncbi Phospholipase A2 (PLA2) enzymes in membrane trafficking: mediators of membrane shape and function
    William J Brown
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Traffic 4:214-21. 2003
    ..The largest class of phospholipases are the phospholipase A(2) (PLA2) enzymes, and these have been most extensively studied for their roles in the generation lipid signaling molecules, ..
  98. ncbi Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation
    Sabine Beck
    Center of Pharmacology, University Hospital Frankfurt, 60590 Frankfurt, Germany
    J Biol Chem 278:29799-812. 2003
    ..The transcriptional pathway mediating this effect is, however, unknown. Because products of PLA2 activity are endogenous activators of peroxisome proliferator-activated receptor alpha (PPAR alpha, we postulated ..
  99. ncbi Pharmacogenetics of antiplatelet drugs
    Ronan Curtin
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    ScientificWorldJournal 2:791-800. 2002
    ..One particular gene variant, the PlA2 polymorphism of the glycoprotein (GP) IIb/IIIa receptor, is now emerging as a probable determinant of the response ..
  100. ncbi [Integrin Beta 3 PlA1/PlA2 polimorphism does not contribute to complications in both type 1 and type 2 diabetes]
    L Pucci
    Divisione di Endocrinologia e Metabolismo, Universita di Pisa, Pisa, Italy
    G Ital Nefrol 20:461-9. 2003
    ..The gene encoding the GPIIIa, a receptor for fibrinogen, vWF and fibronectin, shows polymorphism (PlA1/PlA2); the PlA2 allele has been associated with myocardial infarction, stroke and cardiovascular disease.
  101. ncbi Activation of BK channels in GH3 cells by a c-PLA2-dependent G-protein signaling pathway
    D D Denson
    Dept of Anesthesiology, Emory University School of Medicine, 3B South Emory University Hospital, 1364 Clifton Rd, Atlanta, GA 30322, USA
    J Neurophysiol 93:3146-56. 2005
    BK-channels in GH3 cells are activated by arachidonic acid produced by c-PLA2. beta-adrenergic agonists also activate BK channels and were presumed to do so via production of cAMP...

Research Grants66

  1. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..Preliminary data suggests that Akt2 regulates cardiac glucose metabolism and intracellular phospholipase A2 (PLA2) activity...
  2. Studies of Eicosanoid Biosynthetic Proteins
    Wonhwa Cho; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Arachidonic acid (AA), which is liberated from membrane phospholipids by phospholipase A2 (PLA2), is converted to oxidized lipids collectively known as eicosanoids, including prostaglandins and ..
  3. Biology, Immunology &therapy of Acanthamoeba Keratitis
    Hassan Alizadeh; Fiscal Year: 2013
    ..epithelial cells and induces both apoptosis and arachidonic acid release through a novel pathway involving phospholipase A2 (PLA2) activation...
  4. Role of phospholipase A2 in spinal cord secondary injury
    Xiao Ming Xu; Fiscal Year: 2013
    Role of phospholipase A2 in spinal cord secondary injury There are two mechanisms of damage to the spinal cord after injury: a primary mechanical injury and a secondary injury mediated by multiple injury mechanisms...
  5. Michael H Gelb; Fiscal Year: 2016
    ..from arachidonic acid, which is liberated from the cellular phospholipids by a family of enzymes called phospholipase A2, The mammalian genome encodes 10 secreted phospholipases A2 (sPLA2s), and the role of these enzymes in ..
  6. CYTOSOLIC PHOSPHOLIPASE A2 TRANSFORMED CELLS
    Raphael Nemenoff; Fiscal Year: 2002
    ..b>Phospholipase A2 (PLA2), which hydrolyzes the sn-2 bond of membrane phospholipids, is the enzyme controlling arachidonic acid ..
  7. Michael A Collins; Fiscal Year: 2016
    ..prevent the edema and neurodamage);(c) involves oxidative stress (antioxidants neuroprotect);and (d) requires phospholipase A2 (PLA2) activation, which mobilizes (JO-6 arachidonic acid (AA), a free radical source (PLA2 inhibitors reduce ..
  8. PHOSPHOLIPID TURNOVER IN EXOCRINE PANCREAS
    Ronald Rubin; Fiscal Year: 1991
    ..the hypothesis that the interactions of a phospholipase C (PLC)-mediated pathway, and a Ca2+-dependent phospholipase A2 (PLA2) pathway play a pivotal role in stimulus-secretion coupling in exocrine glands...
  9. William M Nauseef; Fiscal Year: 2016
    ..In addition to PMN, a specific Group IIA phospholipase A2 (GpIIA-PLA2), which is present in plasma of infected animals, tears, and inflammatory fluid, exhibits potent ..
  10. DAVID YIU KWAN HUI; Fiscal Year: 2014
    ..This gene encodes the Group 1B phospholipase A2 protein (PLA2G1B) that hydrolyzes phospholipids to generate free fatty acids and lysophospholipids (lysoPL) ..
  11. NORRIS ISAAC HOLLIE; Fiscal Year: 2014
    ..Recent studies have linked human polymorphisms of the group 1B phospholipase A2 gene (PLA2G1B) with increased central adiposity, which is a risk factor for cardiovascular disease...
  12. Aron B Fisher; Fiscal Year: 2016
    ..developed a model based on lipid binding studies for the coordination of the peroxidase (Prx) and phospholipase (PLA2) activities of the protein. We are now seeking 5 years of support to extend these studies...
  13. Elucidating the Role of Phospholipase in the Epidemic Typhus Rickettsia
    JONATHON PETER AUDIA; Fiscal Year: 2010
    ..provided by applicant): The long-term goal of this R01 application is to elucidate the role(s) of secreted phospholipase A2 (PLA2) in Rickettsia prowazekii pathobiology. R...
  14. Edward A Dennis; Fiscal Year: 2016
    ..years has been to characterize the detailed mechanism of action of various physiologically important forms of phospholipase A2 (PLA2)...
  15. PHYSIOLOGIC PHOSPHOLIPASE A2 ACTIVATION IN NEUTROPHILS
    SUE BAULDRY; Fiscal Year: 2000
    ..Activation of phospholipase A2 (PLA2) is the initial step in production of LTB4 and PAF and demonstration that PMN contain two calcium-..
  16. Robert D Arnold; Fiscal Year: 2016
    ..Recently we identified the presence of PLA2 receptors (PLA2R), in prostate cancer...
  17. Eugene A Podrez; Fiscal Year: 2016
    ..Our preliminary studies demonstrated that a class of products formed as a result of degradation of oxPCCD36 by PLA2 (carboxyalkylpyrolle protein adducts) is a new and powerful platelet agonist, however, the receptors mediating its ..
  18. sPLA2 Selective Degradation of Nanoparticles
    BRIAN S contact CUMMINGS; Fiscal Year: 2010
    ..Glycerophospholipids are degraded in the body by phospholipases, including phospholipase A2 (PLA2)...
  19. GLYCEROLIPIDS AND PROSTAGLANDIN BIOSYNTHESIS
    ATA ABDEL LATIF; Fiscal Year: 2001
    ..The central hypothesis to be tested is that phospholipase A2 (PLA2) activation is a major source for AA release in the ICB...
  20. Astrocytes role in lipid mediated synaptic activity
    Nathan A Smith; Fiscal Year: 2012
    ..In line with this, astrocytes possess Ca2+ -independent PLA2 that can lead to the production of AA in the absence of calcium...
  21. NFkB in the Astrocyte Swelling/Brain Edema with Acute Liver Failure
    MICHAEL DAVID NORENBERG; Fiscal Year: 2012
    ..along with their interaction with inflammatory enzymes, including inducible nitric oxide synthase (iNOS), phospholipase A2 (PLA2), and cyclooxygenase-2 (COX-2) that are regulated by NF-kB, will be investigated...
  22. CORONARY DISEASE MORBIDITY AND MORTALITY IN A POPULATION
    Veronique L Roger; Fiscal Year: 2012
    ..that C-Reactive Protein (CRP) was associated with heart failure (HF) and death while lipoprotein- associated phospholipase A2 (Lp-PLA2), was associated with death but not HF or ischemia post MI...
  23. Lu Qi; Fiscal Year: 2016
    ..Macrophages, a key component of adipose tissue, secrete lipoprotein- associated phospholipase A2 (Lp-PLA2), which hydrolyzes oxidized LDL releasing inflammatory products...
  24. Kathryn M Rexrode; Fiscal Year: 2016
    ..Additionally, markers of endothelial inflammation including Lp-PLA2, and IL-18 will be examined. Finally, telomere length, a marker of biologic aging, will be examined...
  25. SPORE in Pancreatic Cancer
    James Abbruzzese; Fiscal Year: 2009
    ..This project will specifically examine the hypothesis that EGF-EGF receptor interactions control PLA2 and COX2 expression in pancreatic cancer cells and that COX-2 regulates an important cell survival pathway...
  26. Functional and Structural Studies of CD74 Activation
    Elias Lolis; Fiscal Year: 2010
    ..examine the requirement for CD74 in various signaling pathways responsible for MIF biology (MAP kinase cytoplasmic PLA2 activation, expression and activation of COX-2, expression of Toll-like receptor 4, counter-regulation of ..
  27. Lie Gao; Fiscal Year: 2014
    ..This includes the NO/cGMP and PLA2/AA/12-LO/PP2A pathways...
  28. S Jamal Mustafa; Fiscal Year: 2015
    ..endothelial cells (release of NO from A2A andA2B (and A2A/A2B) and the coupling of A1 and A3 (and A1/A3) to PLA2;and the signaling in CASMC in A2A, A2B and A2A/A2B (PKA-p38-MAPK-HSP20) and in A1, A3 and A1/ A3 (PLC2III, PKC1, ..
  29. Aron B Fisher; Fiscal Year: 2015
    ..will evaluate the mechanism for Prdx6-mediated activation of NOX2;we propose that generation of lysoPC by the phospholipase A2 (PLA2) activity of Prdx6 is responsible...
  30. Teal S Hallstrand; Fiscal Year: 2016
    ..This application for sustained support focuses on secreted phospholipase A2 group X (sPLA2-X) in the pathophysiology of asthma...
  31. Cellular and molecular biology of lung surfactant
    Aron B Fisher; Fiscal Year: 2013
    ..Project 6 will continue study of perioxiredoxin 6, a novel lysosomal type phospholipase A2 that was identified by this program...
  32. William J Brown; Fiscal Year: 2016
    ..characterize PLA and LPAT enzymes involved in intracellular membrane trafficking;2) determine the contribution of PLA2 and LPAT enzymes to the production of Golgi coated vesicles and membrane tubules;and 3) determine the molecular ..
  33. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony L Yaksh; Fiscal Year: 2012
    ..that one component of this facilitation arises from lipid mediator release by a constitutively active P38MAPK-PLA2-COX2 cascade...
  34. Lp-PLA2 and Coronary Atherosclerosis in Humans
    Amir Lerman; Fiscal Year: 2013
    ..Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel biomarker for vascular wall inflammation that circulates in the blood bound to both low ..
  35. Function of secreted PLA2 group X in eosinophil biology
    Teal S Hallstrand; Fiscal Year: 2013
    ..We have discovered that secreted PLA2 group X (sPLA2-X) is involved in eosinophil CysLT synthesis, contradicting the long-held view that cytosolic PLA2[..
  36. New Approach to Phospholipidosis Prediction
    Piotr W Rzepecki; Fiscal Year: 2011
    ..These methods have been judged unsatisfactory by the FDA. Human lysosomal phospholipase A2 (LPLA2, group XV PLA2) is a phospholipid processing enzyme central to DIPL...
  37. Roles for Phospholipase A2 Signaling in Prostate Development
    EDWARD MATTHEW SCHAEFFER; Fiscal Year: 2012
    ..Through both gene expression profiling and biochemical techniques we have identified cytosolic phospholipase A2 alpha (cPla2a) as an androgen regulated target of extracellular regulated kinases (Erk1,2)...
  38. OXIDATIVE CELL INJURY: FIRST-EPISODE PSYCHOTIC PATIENTS
    Sahebarao Mahadik; Fiscal Year: 2002
    ..Specific measures will include membrane lipid peroxidation products (malondialdehyde, MDA), phospholipase A2 (PLA2), conjugated dienes and fatty acid contents, levels of carbonylated proteins, and DNA strand breaks...
  39. GTP IN PHOSPHOLIPASE ACTIVATION AND INSULIN RELEASE
    STEWART METZ; Fiscal Year: 2000
    Our recent studies indicated that a phospholipase A2 (PLA2) and a phospholipase D (PLD) are present in pancreatic islets; furthermore, the phospholipid hydrolysis products which they generate (arachidonic acid, lysophospholipids, and ..
  40. PROPERTIES OF CHEMICALLY MODIFIED PHOSPHOLIPASE A-2
    Philip Rosenberg; Fiscal Year: 1993
    Our long term objective is to determine why proteins with phospholipase A2 (PLA2) activity differ so markedly in their toxicological and pharmacological properties even though they have similar enzymatic activities...
  41. EVALUATION OF LIPOXYGENASE-DERIVED PRODUCTS AS MEDIATORS
    Charles Serhan; Fiscal Year: 1990
    ..2) Extracellular phospholipase A2 (PLA2) activity will be determined n and isolated from pleural and synovial fluids...
  42. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Our preliminary results show that CDP-choline affects activation of membrane and mitochondrial phospholipase A2 (PLA2) that is raM-Ca 2+ dependent (characteristic of secretory PLA2; sPLA2), supporting the hypothesis and ..
  43. MECHANISMS OF PHOSPHOLIPASE A2 REGULATION
    John Bell; Fiscal Year: 1990
    ..objective of this research project is to understand the molecular mechanisms of cellular regulation of phospholipase A2 (PLA2)...
  44. Pharmacogenetic Antiplatelet Strategies in CHD Patients
    Glen Cooke; Fiscal Year: 2007
    ..The GPIlb-IIIa receptor is known to be polymorphic and the presence of the PLA2 allele has been associated with an increased prevalence of ischemic syndromes, especially in younger individuals...
  45. CALCIUM INDEPENDENT PLA2 AND ISCHEMIC CELL INJURY
    Didier Portilla; Fiscal Year: 2000
    Activation of calcium-independent phospholipase A2 (CalPLA2) in the proximal tubule contributes to cell injury by the formation of toxic amphiphiles which cause profound inhibition of NaK-ATPase during ischemia...
  46. PLASMALOGEN-SELECTIVE PLA2 ACTIVATION IN ISCHEMIA
    Jane McHowat; Fiscal Year: 1999
    ..LPC) production which appears to be mediated by activation of a novel calcium-independent phospholipase A2 (PLA2) with a distinct preference for ether-linked phospholipid substrates, including plasmalogens...
  47. REGULATION OF PROSTAGLANDIN BIOSYNTHESIS IN PARTURITION
    EDWARD DENNIS; Fiscal Year: 1999
    ..is the release of arachidonic acid from the sn-2 position of membrane phospholipids by phospholipase (PLA2)...
  48. In vivo biosensor screen for mutants in lipid metabolism
    Steven Farber; Fiscal Year: 2005
    ..We produced fluorescent lipids that are substrates for phospholipase A2 (PLA2), an important signaling and digestive enzyme present in the cytoplasm and brush border of the ..
  49. Regulatory Mechanisms of Secretory Phospholipases A2
    SUREN TATULIAN; Fiscal Year: 2004
    ..Our long-term goal is to identify the structural basis for the activation of secretory phospholipases A2 (PLA2) upon binding to the aggregated substrate (interfacial activation)...
  50. PLA2 activation by mast cell tryptase in IC
    Jane McHowat; Fiscal Year: 2007
    ..receptor-2 (PAR-2) on urothelial and endothelial cells in the bladder and resulting in increased phospholipase A2 (PLA2) activity and accelerated production of inflammatory phospholipid metabolites such as eicosanoids and ..
  51. The Function of Phospholipase A2 in Islet Beta-cells
    Zhongmin Ma; Fiscal Year: 2007
    ..polypeptide (GIP) and cholecystokinin-8 (CCK-8) also stimulate release of AA by activating islet phospholipase A2 (PLA2)...
  52. PLATELET P1A2--STUDIES ON A PRO THROMBOTIC POLYMORPHISM
    Paul Bray; Fiscal Year: 2001
    ..are highly polymorphic, and our preliminary studies demonstrate a statistically significant association between the PlA2 polymorphism on beta3 and premature ischemic coronary events, particularly in young individuals...
  53. REGULATION OF ENDOTHELIAL CELL PHOSPHOLIPASES A2 AND C
    Thomas Martin; Fiscal Year: 1990
    ..PIns-derived second messengers mobilize Ca2+ and activate phospholipase A2 (PLA2) which releases arachidonic acid (AA) for PGI2 synthesis...
  54. XENOBIOTICS AND ALLERGIC INFLAMMATION
    Andrew Saxon; Fiscal Year: 2000
    ..The applicant now plans the following: (1) to identify the phospholipase A2 (PLA2) enzymes that provide arachidonate to PGS1 and PGS2, (2) to determine the subcellular localizatio of ..
  55. TOXIC LIVER INJURY: CA2+, PLA2, PROTEASES & EICONSANOIDS
    ERIC GLENDE; Fiscal Year: 1993
    ..involves a toxigenic sequence characterized by a rise in cytosolic free calcium ion and activation of phospholipase A2 (PLA2) and cytosolic proteases leading to degeneration of the cell membrane and death of the cell...
  56. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony Yaksh; Fiscal Year: 2005
    ..is inhibition of cyclooxygenase (COX), an enzyme converting arachidonic acid (AA) generated by phospholipases (PLA2) to prostaglandins (PG)...
  57. Phospholipases in the Pathogenesis of M. tuberculosis
    Sarah Parker; Fiscal Year: 2006
    ..Evidence suggests that phospholipase A2 (PLA2), which is described here for the first time in M...
  58. QUANTITATIVE MICROBIOLOGIC MODEL FOR PRETERM DELIVERY
    Andrew Onderdonk; Fiscal Year: 2004
    ..It has been shown that the levels of a bacterial phospholipase, PLA2, increase in concentration between 20 and 30 weeks of gestation in women who deliver at less than 37 weeks ..
  59. Regulation of CFTR by adenosine, A2 receptors, and PLA2
    John Clancy; Fiscal Year: 2004
    ..Our preliminary results suggest that A2 receptors activate CFTR through phospholipase A2 (PLA2) and arachidonic acid...
  60. MECHANISM OF PHOSPHOLIPASE A2
    Ming Daw Tsai; Fiscal Year: 2000
    The objective of this project is to understand the structure-function relationship of phospholipase A2 (PLA2) at the highest possible resolution...
  61. FREE RADICALS AND MUSCLE DYSFUNCTION IN HEART FAILURE
    GERALD SUPINSKI; Fiscal Year: 2005
    ..We postulate that heart failure elicits an increase in myocyte phospholipase A2 (PLA2) activity levels, and that arachidonic acid generated by PLA2 interacts with the electron transport ..
  62. NEUTROPHILS AND BACTERIAL PHOSPHOLIPID DEGRADATION
    Jerrold Weiss; Fiscal Year: 2002
    ..applicant's abstract): This proposal concerns the role and regulation of the action of mammalian Group IIA phospholipase A2 (PLA2) during inflammation and the determinants of the degradation of Gram-negative bacterial ..
  63. PLA2 OVARIAN CANCER DIAGNOSTIC AND THERAPEUTIC
    Jeff Parrott; Fiscal Year: 1999
    ..b>Phospholipase A2 (PLA2) is a LPA generating enzyme and presents in ascites fluid...
  64. RENAL PROXIMAL TUBULE TRANSPORT--HORMONAL REGULATION
    Richard Miller; Fiscal Year: 1993
    ..and ion channels regulated by G proteins (effectors) may include adenylyl cyclase (AC), phospholipases A2 and C (PLA2 and PLC), and K and Ca channels. Most hormones regulate some, but not all of these effectors...
  65. Effects of arachidonic acid on the dopamine transporter
    Dove Keith; Fiscal Year: 2004
    ..of the DA D2 type receptor initiates many signaling cascades, including G-protein mediated stimulation of phospholipase A2 (PLA2) and adenylyl cyclase. PLA2 liberates arachidonic acid (AA) from membrane phospholipids...
  66. Role of Vimentin, sPLA2 and LysoPC in Autoimmune Disease
    SUZANNE BARBOUR; Fiscal Year: 2005
    ..Products of the reaction catalyzed by the phospholipases A2 (PLA2) have been shown to induce monocyte chemotaxis...