PLA2G1B

Summary

Gene Symbol: PLA2G1B
Description: phospholipase A2 group IB
Alias: PLA2, PLA2A, PPLA2, phospholipase A2, phosphatidylcholine 2-acylhydrolase 1B, phospholipase A2, group IB (pancreas)
Species: human
Products:     PLA2G1B

Top Publications

  1. Sapirstein A, Bonventre J. Phospholipases A2 in ischemic and toxic brain injury. Neurochem Res. 2000;25:745-53 pubmed
    ..We postulated that group IV large molecular weight, cytosolic phospholipase A2 (cPLA2) has a unique role in neurotoxicity associated with ischemic or toxin stress...
  2. Siddiqui F, Naqvi S, Abidi L, Faizi S, Lubna -, Avesi L, et al. Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation. J Ethnopharmacol. 2016;182:221-34 pubmed publisher
    ..TPA)-induced ear edema accompanied by histological studies of mice ear sections and phospholipase A2 (PLA2)-induced mice paw edema. (2) Carrageenan and glycogen-induced peritonitis in rodents...
  3. Nandi A, Wadhwani N, Joshi S. Altered metabolic homeostasis between vitamin D and long chain polyunsaturated fatty acids in preeclampsia. Med Hypotheses. 2017;100:31-36 pubmed publisher
    ..are known to increase reactive oxygen species (ROS) production which in turn leads to increased expression of phospholipase A2 (PLA2) and cyclooxygenase-2 (COX-2)...
  4. Ong W, Farooqui T, Kokotos G, Farooqui A. Synthetic and natural inhibitors of phospholipases A2: their importance for understanding and treatment of neurological disorders. ACS Chem Neurosci. 2015;6:814-31 pubmed publisher
    ..alterations in phospholipid metabolism, accumulation of lipid peroxides, and increased activities of brain phospholipase A2 isoforms...
  5. Bouaziz M, Bejaoui S, Rabeh I, Besbes R, El Cafsi M, Falcon J. Impact of temperature on sea bass, Dicentrarchus labrax, retina: Fatty acid composition, expression of rhodopsin and enzymes of lipid and melatonin metabolism. Exp Eye Res. 2017;159:87-97 pubmed publisher
    ..acid elongase-5 (ELOVL5), sterol regulatory element-binding protein-1 (SREBP-1), triglyceride lipase and phospholipase A2 (PLA2)...
  6. Diwan V, Mistry A, Gobe G, Brown L. Adenine-induced chronic kidney and cardiovascular damage in rats. J Pharmacol Toxicol Methods. 2013;68:197-207 pubmed publisher
    ..for oxidative stress (HO-1), fibrosis (TGF-β, α-SMA) and inflammation (TNF-α, NF-κB p52, NF-κB p50, PLA2 and ED1) were measured, along with cardiovascular parameters (blood pressure, left ventricular stiffness, vascular ..
  7. Deng X, Wang J, Jiao L, Utaipan T, Tuma Kellner S, Schmitz G, et al. iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling. Biochim Biophys Acta. 2016;1861:449-61 pubmed publisher
    PLA2G6 or GVIA calcium-independent PLA2 (iPLA2β) is identified as one of the NAFLD modifier genes in humans, and thought to be a target for NAFLD therapy...
  8. Jablonická V, Mansfeld J, Heilmann I, Oblozinsky M, Heilmann M. Identification of a secretory phospholipase A2 from Papaver somniferum L. that transforms membrane phospholipids. Phytochemistry. 2016;129:4-13 pubmed publisher
    The full-length sequence of a new secretory phospholipase A2 was identified in opium poppy seedlings (Papaver somniferum L.)...
  9. Chang H, Wang Q, Shi T, Huo K, Li C, Zhang Q, et al. Effect of DanQi Pill on PPAR?, lipid disorders and arachidonic acid pathway in rat model of coronary heart disease. BMC Complement Altern Med. 2016;16:103 pubmed publisher
    ..In addition, levels of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX-2) were up-regulated...

More Information

Publications142 found, 100 shown here

  1. Tan N, Fung S, Tan K, Yap M, Gnanathasan C, Tan C. Functional venomics of the Sri Lankan Russell's viper (Daboia russelii) and its toxinological correlations. J Proteomics. 2015;128:403-23 pubmed publisher
    ..The four main protein families are phospholipase A2 (PLA2, 35.0%), snaclec (SCL, 22...
  2. Artemeva N, Safarova M, Ezhov M, Afanasieva O, Dmitrieva O, Pokrovsky S. Lowering of lipoprotein(a) level under niacin treatment is dependent on apolipoprotein(a) phenotype. Atheroscler Suppl. 2015;18:53-8 pubmed publisher
    ..0 g. Subjects were evaluated for Lp(a), lipids, high-sensitivity C-reactive protein, lipoprotein-associated phospholipase A2 (Lp-PLA2), and fibrinolytic markers (plasminogen activator inhibitor-1, tissue plasminogen activator/..
  3. Wang J, Lu L, Wang Y, Wu Y, Han J, Wang W, et al. Qishenyiqi Dropping Pill attenuates myocardial fibrosis in rats by inhibiting RAAS-mediated arachidonic acid inflammation. J Ethnopharmacol. 2015;176:375-84 pubmed publisher
    ..Expressions of phospholipase A2 (PLA2), cyclooxygenase 1 (COX1) and COX2 were also down-regulated in the QSDP-treated group...
  4. Vulfius C, Kasheverov I, Kryukova E, Spirova E, Shelukhina I, Starkov V, et al. Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors. PLoS ONE. 2017;12:e0186206 pubmed publisher
    ..We also wished to explore whether mammalian PLA2s interact with nAChRs, and have examined non-toxic PLA2 from porcine pancreas...
  5. Han G, Na J, Chun Y, Kumar S, Kim W, Kim Y. Chlorine dioxide enhances lipid peroxidation through inhibiting calcium-independent cellular PLA2 in larvae of the Indianmeal moth, Plodia interpunctella. Pestic Biochem Physiol. 2017;143:48-56 pubmed publisher
    ..Our results also suggest that ClO2 can elevate lipid peroxidation through inhibiting Pi-iPLA2 expression in addition to direct ROS production. ..
  6. Luczaj W, Jarocka Karpinska I, Sierakowski S, Andrisic L, Zarkovic N, Skrzydlewska E. Lipid peroxidation in Rheumatoid arthritis; consequences and monitoring. Free Radic Biol Med. 2014;75 Suppl 1:S49 pubmed publisher
    ..b>Phospholipase A2 (PLA2), platelet-activating factor acetylhydrolase (PAF-AH) and glutathione peroxidase (GSH-Px) activity were ..
  7. Serino Silva C, Morais Zani K, Hikari Toyama M, Toyama D, Gaeta H, Rodrigues C, et al. Purification and characterization of the first ?-phospholipase inhibitor (?PLI) from Bothrops jararaca snake serum. PLoS ONE. 2018;13:e0193105 pubmed publisher
    Phospholipases A2 (PLA2) are enzymes acting on the cell membrane phospholipids resulting in fatty acids and lysophospholipids and deconstructing the cell membrane...
  8. Lu X, Xu X, Zhang Y, Zhang Y, Wang C, Huo X. Elevated inflammatory Lp-PLA2 and IL-6 link e-waste Pb toxicity to cardiovascular risk factors in preschool children. Environ Pollut. 2018;234:601-609 pubmed publisher
    ..Serum biomarkers including lipid profiles and inflammatory cytokines, and plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) were detected...
  9. Vijay R, Hua X, Meyerholz D, Miki Y, Yamamoto K, Gelb M, et al. Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection. J Exp Med. 2015;212:1851-68 pubmed publisher
    ..Here, we show that age-dependent increases of one such factor in the lungs, a phospholipase A2 (PLA2) group IID (PLA2G2D) with antiinflammatory properties, contributed to worse outcomes in mice infected ..
  10. Tan C, Tan K, Fung S, Tan N. Venom-gland transcriptome and venom proteome of the Malaysian king cobra (Ophiophagus hannah). BMC Genomics. 2015;16:687 pubmed publisher
    ..The presence of toxic enzymes such as LAAOs, SVMPs and PLA2 would explain tissue inflammation and necrotising destruction in local envenoming...
  11. Dirandeh E, Towhidi A, Pirsaraei Z, Saberifar T, Akhlaghi A, Roodbari A. The endometrial expression of prostaglandin cascade components in lactating dairy cows fed different polyunsaturated fatty acids. Theriogenology. 2015;83:206-12 pubmed publisher
    ..F synthase [PGFS], prostaglandin E synthase [PGES], prostaglandin endoperoxide synthase-2 [PGHS-2]), phospholipase A2 (PLA2), peroxisome proliferator-activated receptors [PPAR])...
  12. McCrea C, West S, Kris Etherton P, Lambert J, Gaugler T, Teeter D, et al. Effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: results of a randomized crossover study and in vitro experiments. J Transl Med. 2015;13:7 pubmed publisher
    ..The spice blend and several of the individual spices dose-dependently inhibited PL and PLA2 activity in vitro. Inclusion of spices may attenuate postprandial lipemia via inhibition of PL and PLAâ‚‚...
  13. Tu S, Xiao F, Min X, Chen H, Fan X, Cao K. Catechin Attenuates Coronary Heart Disease in a Rat Model by Inhibiting Inflammation. Cardiovasc Toxicol. 2018;18:393-399 pubmed publisher
    ..Additionally, several inflammatory biomarkers or cytokines such as C-reactive protein, lipoprotein-associated phospholipase A2 (Lp-PLA2), interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-?) were inhibited by catechin...
  14. Elbaradie K, Wang Y, Boyan B, Schwartz Z. Sex-specific response of rat costochondral cartilage growth plate chondrocytes to 17?-estradiol involves differential regulation of plasma membrane associated estrogen receptors. Biochim Biophys Acta. 2013;1833:1165-72 pubmed publisher
    ..estrogen receptors (ERs); however 17?-estradiol (E2) induces membrane responses leading to activation of phospholipase A2 (PLA2), phospholipase C (PLC), prostaglandin E2 (PGE2) production, protein kinase C (PKC), and ultimately ..
  15. Vinuesa A, Pomilio C, Menafra M, Bonaventura M, Garay L, Mercogliano M, et al. Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity. Psychoneuroendocrinology. 2016;72:22-33 pubmed publisher
    ..After four months of HFD exposure, mice presented dyslipidemia, increased Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, hepatic insulin resistance and inflammation...
  16. Ma W, Paik D, Barile G. Bioactive lysophospholipids generated by hepatic lipase degradation of lipoproteins lead to complement activation via the classical pathway. Invest Ophthalmol Vis Sci. 2014;55:6187-93 pubmed publisher
    ..HDL) lipoproteins with hepatic lipase (HL), cholesterol esterase (CE), and lipoprotein-associated phospholipase A2 (Lp-PLA2)...
  17. Sharma M, Das D, Iyer J, Kini R, Doley R. Unveiling the complexities of Daboia russelii venom, a medically important snake of India, by tandem mass spectrometry. Toxicon. 2015;107:266-81 pubmed publisher
    ..b>Phospholipase A2 (PLA2), serine proteases, metalloproteases, cysteine-rich secretory proteins, l-amino acid oxidase, C-type ..
  18. Lamraoui A, Adi Bessalem S, Laraba Djebari F. Immunopathologic effects of scorpion venom on hepato-renal tissues: Involvement of lipid derived inflammatory mediators. Exp Mol Pathol. 2015;99:286-96 pubmed publisher
    ..In the study here, the involvement of phospholipase A2 (PLA2) and cyclo-oxygenase (COX)-derived metabolites in hepatic and renal inflammation responses were ..
  19. Ugidos I, Santos Galdiano M, Pérez Rodríguez D, Anuncibay Soto B, Font Belmonte E, López D, et al. Neuroprotective effect of 2-hydroxy arachidonic acid in a rat model of transient middle cerebral artery occlusion. Biochim Biophys Acta Biomembr. 2017;1859:1648-1656 pubmed publisher
    ..We conclude that 2OAA treatment results in a strong neuroprotective effect that seems to rely on a decrease in PLA2 transcriptional activity...
  20. Lin X, Xu M, Tang J, Mai L, Wang X, Ren M, et al. Effect of intensive insulin treatment on plasma levels of lipoprotein-associated phospholipase A2 and secretory phospholipase A2 in patients with newly diagnosed type 2 diabetes. Lipids Health Dis. 2016;15:203 pubmed
    ..05), while the Lp-PLA2 level changed only in those with macroangiopathy (P?<?0.05)...
  21. Kumar J, Basavarajappa B, Vishwanath B, Gowda T. Biochemical and pharmacological characterization of three toxic phospholipase A2s from Daboia russelii snake venom. Comp Biochem Physiol C Toxicol Pharmacol. 2015;168:28-38 pubmed publisher
    Three isoenzymes of phospholipase A2 (PLA2), VRV-PL-IIIc, VRV-PL-VII, and VRV-PL-IX were isolated from Daboia russelii snake venom. The venom, upon gel filtration on Sephadex G-75 column, resolved into six peaks (DRG75 I-VI)...
  22. Dutta S, Gogoi D, Mukherjee A. Anticoagulant mechanism and platelet deaggregation property of a non-cytotoxic, acidic phospholipase A2 purified from Indian cobra (Naja naja) venom: inhibition of anticoagulant activity by low molecular weight heparin. Biochimie. 2015;110:93-106 pubmed publisher
    In the present study, anticoagulant and platelet modulating activities of an acidic phospholipase A2 (NnPLA2-I) purified from Indian cobra Naja naja venom was investigated. The NnPLA2-I displayed a mass of 15.2 kDa and 14,186...
  23. Oliveira C, Santos Filho N, Menaldo D, Boldrini França J, Giglio J, Calderon L, et al. Structural and functional characterization of a ?-type phospholipase A2 inhibitor from bothrops jararacussu snake plasma. Curr Top Med Chem. 2011;11:2509-19 pubmed
    ..The present work had as objectives the isolation and functional/structural characterization of a ?-type phospholipase A2 inhibitor (PLI) from Bothrops jararacussu snake plasma, named ?BjussuMIP...
  24. Chauhan A, Sharma U, Jagannathan N, Gupta Y. Rapamycin ameliorates brain metabolites alterations after transient focal ischemia in rats. Eur J Pharmacol. 2015;757:28-33 pubmed publisher
    ..Reperfusion was done 2h after ischemia. Twenty-four hours after ischemia phospholipase A2 (PLA2) levels and metabolic changes were assessed...
  25. Yarla N, Azad R, Basha M, Rajack A, Kaladhar D, Allam B, et al. 5-Lipoxygenase and cyclooxygenase inhibitory dammarane triterpenoid 1 from Borassus flabellifer seed coat inhibits tumor necrosis factor-α secretion in LPSInduced THP-1 human monocytes and induces apoptosis in MIA PaCa-2 pancreatic cancer cells. Anticancer Agents Med Chem. 2015;15:1066-77 pubmed
    b>Phospholipase A2 (PLA2), Cyclooxygenase (COX) and 5-Lipoxygenase (5-LOX) are arachidonic acid metabolizing enzymes and their inhibitors have been developed as therapeutic molecules for cancer and inflammation related disorders...
  26. Viala V, Hildebrand D, Trusch M, Fucase T, Sciani J, Pimenta D, et al. Venomics of the Australian eastern brown snake (Pseudonaja textilis): Detection of new venom proteins and splicing variants. Toxicon. 2015;107:252-65 pubmed publisher
    ..and the identification of the following: prothrombinase coagulation factors, neurotoxic textilotoxin phospholipase A2 (PLA2) subunits and "acidic PLA2", three-finger toxins (3FTx) and the Kunitz-type protease inhibitor ..
  27. Lausada N, Arnal N, Astiz M, Marín M, Lofeudo J, Stringa P, et al. Dietary fats significantly influence the survival of penumbral neurons in a rat model of chronic ischemic by modifying lipid mediators, inflammatory biomarkers, NOS production, and redox-dependent apoptotic signals. Nutrition. 2015;31:1430-42 pubmed publisher
    ..from different zones and analyzed by redox status, inflammatory markers, ceramide, and arachidonate content, phospholipase A2, NOS, and proteases...
  28. Choi J, Lee M, Kim Y, Shim J, Han S, Lee K, et al. Isolation of genes involved in pancreas regeneration by subtractive hybridization. Biol Chem. 2010;391:1019-29 pubmed publisher
    ..Twelve genes (adipsin, Aplp2, Clu, Col1a2, Glul, Krt8, Lgmn, LOC299907, LOC502894, Pla2g1b, Reg3? and Xbp1) were identified, and RT-PCR and real-time PCR analyses were performed to validate their ..
  29. Garg P, McClelland R, Jenny N, Criqui M, Greenland P, Rosenson R, et al. Lipoprotein-associated phospholipase A2 and risk of incident cardiovascular disease in a multi-ethnic cohort: The multi ethnic study of atherosclerosis. Atherosclerosis. 2015;241:176-82 pubmed publisher
    Prospective studies reporting a positive association of lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity with incident cardiovascular disease (CVD) have included primarily white individuals...
  30. Zhang J, Xu D, Liu X, Bi S, Zhao T, Sui S, et al. Darapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, Reduces Rho Kinase Activity in Atherosclerosis. Yonsei Med J. 2016;57:321-7 pubmed publisher
    Increased lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and Rho kinase activity may be associated with atherosclerosis...
  31. Wallentin L, Held C, Armstrong P, Cannon C, Davies R, Granger C, et al. Lipoprotein-Associated Phospholipase A2 Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease. J Am Heart Assoc. 2016;5: pubmed publisher
    We evaluated lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in patients with stable coronary heart disease before and during treatment with darapladib, a selective Lp-PLA2 inhibitor, in relation to outcomes and the effects of ..
  32. Dowell N, Giorgianni M, Kassner V, Selegue J, Sanchez E, Carroll S. The Deep Origin and Recent Loss of Venom Toxin Genes in Rattlesnakes. Curr Biol. 2016;26:2434-2445 pubmed publisher
    The genetic origin of novel traits is a central but challenging puzzle in evolutionary biology. Among snakes, phospholipase A2 (PLA2)-related toxins have evolved in different lineages to function as potent neurotoxins, myotoxins, or ..
  33. Lue H, Podolak J, Kolahi K, Cheng L, Rao S, Garg D, et al. Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade. Genes Dev. 2017;31:2067-2084 pubmed publisher
    ..Specifically, we found that survival of cancer cells was critically dependent on phospholipase A2 (PLA2) to mobilize lysophospholipids and free fatty acids to sustain fatty acid oxidation and oxidative ..
  34. Righino B, Minucci A, Pirolli D, Capoluongo E, Conti G, De Luca D, et al. In silico investigation of the molecular effects caused by R123H variant in secretory phospholipase A2-IIA associated with ARDS. J Mol Graph Model. 2018;81:68-76 pubmed publisher
    b>Phospholipase A2-IIA catalyzes the hydrolysis of the sn-2 ester of glycerophospholipids. A rare c.428G > A (p...
  35. Fisher A, Dodia C. Lysosomal-type PLA2 and turnover of alveolar DPPC. Am J Physiol Lung Cell Mol Physiol. 2001;280:L748-54 pubmed
    This study evaluated the role of a lysosomal-type phospholipase A2 (aiPLA(2)) in the degradation of internalized dipalmitoylphosphatidylcholine (DPPC) and in phospholipid synthesis by the rat lung...
  36. Zarini S, Gijón M, Folco G, Murphy R. Effect of arachidonic acid reacylation on leukotriene biosynthesis in human neutrophils stimulated with granulocyte-macrophage colony-stimulating factor and formyl-methionyl-leucyl-phenylalanine. J Biol Chem. 2006;281:10134-42 pubmed
  37. Pan Y, Wan J, Liu Y, Yang Q, Liang W, Singhal P, et al. sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor. Sci Rep. 2014;4:6660 pubmed publisher
    The M-type phospholipase A2 receptor (PLA2R) is expressed in podocytes in human glomeruli...
  38. Cabral M, Martín Venegas R, Moreno J. Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. Physiol Rep. 2015;3: pubmed publisher
    ..We also note the possible participation of the PLC-IP3-Ca(2+)/DAG-PKC signaling pathways in cytosolic PLA2 and [(3)H]AA release induced by LTD4-CystLT1R interaction...
  39. Park Y, Kumar S, Kanumuri R, Stanley D, Kim Y. A novel calcium-independent cellular PLA2 acts in insect immunity and larval growth. Insect Biochem Mol Biol. 2015;66:13-23 pubmed publisher
    b>Phospholipase A2 (PLA2) catalyzes the position-specific hydrolysis of fatty acids linked to the sn-2 position of phospholipids (PLs)...
  40. Musatov A, Varhač R, Hosler J, Sedlák E. Delipidation of cytochrome c oxidase from Rhodobacter sphaeroides destabilizes its quaternary structure. Biochimie. 2016;125:23-31 pubmed publisher
    ..b>Phospholipase A2 (PLA2) hydrolysis of phospholipids that are co-purified with the enzyme removes all but two tightly bound ..
  41. Iglesias A, Lage S, Cadavid M, Loza M, Brea J. Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A Receptors and Identification of Active Compounds by High-Throughput Screening. J Biomol Screen. 2016;21:816-23 pubmed publisher
    ..functional selectivity phenomenon was observed, with its various ligands exerting differential effects on the phospholipase A2 (PLA2) and phospholipase C (PLC) signaling pathways...
  42. Sun W, Ji W, Hu Q, Yu J, Wang C, Qian C, et al. Transformable DNA nanocarriers for plasma membrane targeted delivery of cytokine. Biomaterials. 2016;96:1-10 pubmed publisher
    ..This formulation is comprised of a phospholipase A2 (PLA2) degradable liposome as a shell, and complementary DNA nanostructures (designated as nanoclews) ..
  43. Fagerberg B, Borné Y, Barregard L, Sallsten G, Forsgard N, Hedblad B, et al. Cadmium exposure is associated with soluble urokinase plasminogen activator receptor, a circulating marker of inflammation and future cardiovascular disease. Environ Res. 2017;152:185-191 pubmed publisher
    ..01) after full adjustment. Blood cadmium was not associated with C-reactive protein, white blood cell count and Lp-PLA2 but with neutrophil/lymphocyte ratio in one of two statistical models...
  44. Ding H, Zhang T, Du Y, Liu B, Liu Y, Wang F. HUCMNCs protect vascular endothelium and prevent ISR after endovascular interventional therapy for vascular diseases in T2DM rabbits. Mol Cell Biochem. 2017;433:161-167 pubmed publisher
    ..of soluble vascular endothelial cadherin (VE-cad) and plasma concentration of lipoprotein-associated phospholipase A2 (Lp-PLA2) were determined with enzyme-linked immunosorbent assay before and after the transplantation...
  45. Mikami S, Aiboshi J, Kobayashi T, Kojima M, Morishita K, Otomo Y. Discrete roles of intracellular phospholipases A2 in human neutrophil cytotoxicity. J Trauma Acute Care Surg. 2015;79:238-46 pubmed publisher
    The role of calcium-independent phospholipase A2 (iPLA2), a component of the three major PLA2 families, in acute/chronic inflammatory processes remains elusive...
  46. Boillot A, Demmer R, Mallat Z, Sacco R, Jacobs D, Benessiano J, et al. Periodontal microbiota and phospholipases: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Atherosclerosis. 2015;242:418-23 pubmed publisher
    ..Secretory phospholipase A2 (s-PLA2) and Lipoprotein-associated PLA2 (Lp-PLA2) are inflammatory enzymes associated with atherosclerosis...
  47. Sakasegawa S, Maeba R, Murayama K, Matsumoto H, Sugimori D. Hydrolysis of plasmalogen by phospholipase A1 from Streptomyces albidoflavus for early detection of dementia and arteriosclerosis. Biotechnol Lett. 2016;38:109-16 pubmed publisher
    ..avermitilis JCM5070-but not phospholipase B from Streptomyces sp. NA684, PLA2-Nagase from S. avermitilis, PLA2IIL from S...
  48. Liu J, Guo K, Lu H, Li M, Lai W, Guo Z. [Red blood cell distribution width combined with lipoprotein-associated phospholipase A2 detection for improving diagnostic accuracy of coronary artery stenosis in patients with coronary artery disease]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:875-9 pubmed
    To study the association of red blood cell distribution width (RDW) and lipoprotein-associated phospholipase A2 (LP-PLA2) with the degree of coronary artery stenosis in patients with coronary artery disease (CAD) and the value of RDW ..
  49. Jung K, Baek H, Shin D, Lee G, Park S, Lee S, et al. Protective Effects of Intratracheally-Administered Bee Venom Phospholipase A2 on Ovalbumin-Induced Allergic Asthma in Mice. Toxins (Basel). 2016;8: pubmed publisher
    ..In the present study, we examined the capacity of phospholipase A2 (PLA2), one of the major components of bee venom (BV), to reduce airway inflammation and improve lung ..
  50. Xia W, Xie L, Cao B, Cheng S, Wan H, Liu H. Genes involved in leukotriene synthesis pathway are dynamically regulated during lung development in Rhesus monkeys. Prostaglandins Leukot Essent Fatty Acids. 2017;122:1-6 pubmed publisher
    ..The results showed that the expression levels of PLA2G1B, PLA2G10, PLA2G2D, ALOX5, and ALOX5AP increased dramatically in the lung of Rhesus monkey, reflecting the changes ..
  51. Sun L, Yang X, Jiang J, Hu X, Qing Y, Wang D, et al. Identification of the Niacin-Blunted Subgroup of Schizophrenia Patients from Mood Disorders and Healthy Individuals in Chinese Population. Schizophr Bull. 2017;: pubmed publisher
    ..skin test might reflect abnormalities in membrane fatty acid composition, which could be induced by increased PLA2 enzyme activity, in vivo oxidative stress or lipid metabolism imbalance in SZ...
  52. Strauss J, Zhang X, Barron Y, Ganguli R, Nimgaonkar V. Lack of association between schizophrenia and a pancreatic phospholipase A-2 gene (PLA2G1B) polymorphism. Psychiatr Genet. 1999;9:153-5 pubmed
    ..participated in a case-control association study in which a trinucleotide repeat polymorphism of pancreatic phospholipase A2 group 1B (PLA2G1B) was examined...
  53. Allal C, Buisson Brenac C, Marion V, Claudel Renard C, Faraut T, Dal Monte P, et al. Human cytomegalovirus carries a cell-derived phospholipase A2 required for infectivity. J Virol. 2004;78:7717-26 pubmed
    ..We have identified a phospholipase A2 (PLA2) activity borne by HCMV by using an assay based on the hydrolysis of fluorescent phosphatidylcholine...
  54. Zeng L, Yan J, Luo L, Zhang D. Effects of Pu-erh tea aqueous extract (PTAE) on blood lipid metabolism enzymes. Food Funct. 2015;6:2008-16 pubmed publisher
    ..tea aqueous extract (PTAE) on the central enzymes of blood lipid metabolism, including lipoprotein-associated phospholipase A2 (Lp-PLA2), lecithin: cholesterol acyltransferase (LCAT), 3-hydroxy-3-methylglutaryl coenzyme A reductase (..
  55. Ahmed M, Honisch S, Pelzl L, Fezai M, Hosseinzadeh Z, Bock C, et al. Up-regulation of epithelial Na(+) channel ENaC by human parvovirus B19 capsid protein VP1. Biochem Biophys Res Commun. 2015;468:179-84 pubmed publisher
    ..The virus is effective in part by lysophosphatidylcholine-producing phospholipase A2 (PLA2) activity of B19V capsid protein VP1...
  56. Lewin M, Samuel S, Merkel J, Bickler P. Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation. Toxins (Basel). 2016;8: pubmed publisher
    ..An estimated 75% of fatalities from snakebite occur outside the hospital setting. Because phospholipase A2 (PLA2) activity is an important component of venom toxicity, we sought candidate PLA2 inhibitors by directly ..
  57. Tessmer M, Anderson D, Buchaklian A, Frank D, Feix J. Cooperative Substrate-Cofactor Interactions and Membrane Localization of the Bacterial Phospholipase A2 (PLA2) Enzyme, ExoU. J Biol Chem. 2017;292:3411-3419 pubmed publisher
    ..Thus, ubiquitin and the substrate lipid bilayer act synergistically to induce a conformational rearrangement in the C-terminal domain of ExoU. ..
  58. Alekseeva A, Tretiakova D, Chernikov V, Utkin Y, Molotkovsky J, Vodovozova E, et al. Heterodimeric V. nikolskii phospholipases A2 induce aggregation of the lipid bilayer. Toxicon. 2017;133:169-179 pubmed publisher
    ..A2 (PLA2s) from Vipera nikolskii, which comprises enzymatically active basic subunit and inactive acidic PLA2 homologue, on the lipid bilayer results in the aggregation and stacking of bilayers...
  59. Giannotti K, Leiguez E, Carvalho A, Nascimento N, Matsubara M, Fortes Dias C, et al. A snake venom group IIA PLA2 with immunomodulatory activity induces formation of lipid droplets containing 15-d-PGJ2 in macrophages. Sci Rep. 2017;7:4098 pubmed publisher
  60. Sinderewicz E, Grycmacher K, Boruszewska D, Kowalczyk Zieba I, Staszkiewicz Chodor J, Łukaszuk K, et al. Expression of genes for enzymes synthesizing lysophosphatidic acid, its receptors and follicle developmental factors derived from the cumulus-oocyte complex is dependent on the ovarian follicle type in cows. Anim Reprod Sci. 2018;192:242-250 pubmed publisher
    ..were determined by real-time PCR for receptors for LPA (LPARs), enzymes synthesizing LPA (autotaxin (AX) and phospholipase A2 (PLA2)), BMP15, GDF9, CTSZ, CTSB and FST in COCs isolated from healthy, transitional and atretic follicles...
  61. Ossoli A, Neufeld E, Thacker S, Vaisman B, Pryor M, Freeman L, et al. Lipoprotein X Causes Renal Disease in LCAT Deficiency. PLoS ONE. 2016;11:e0150083 pubmed publisher
    ..Endocytosed LpX appeared to be degraded by both human podocyte and mesangial cell lysosomal PLA2 and induced podocyte secretion of pro-inflammatory IL-6 in vitro and renal Cxl10 expression in Lcat-/- mice...
  62. Wu H, Bogdanov M, Zhang Y, Sun K, Zhao S, Song A, et al. Hypoxia-mediated impaired erythrocyte Lands' Cycle is pathogenic for sickle cell disease. Sci Rep. 2016;6:29637 pubmed publisher
    ..that hypoxia-mediated ERK activation underlies imbalanced Lands' cycle by preferentially inducing the activity of PLA2 but not LPCAT in human and mouse SCD erythrocytes...
  63. Park S, Kim M, Ha J, Lee N, Park J, Lee J, et al. Protective effects of TES trioleate, an inhibitor of phospholipase A2, on reactive oxygen species and UVA-induced cell damage. J Photochem Photobiol B. 2016;164:30-35 pubmed publisher
    ..sulfonic acid (TES trioleate) is an inhibitor of phospholipase A2 (PLA2), which hydrolyzes cell membrane phospholipids to produce arachidonic acid (AA) and lysophospholipids (LysoPLs)...
  64. Jridi I, Catacchio I, Majdoub H, Shahbazzadeh D, El Ayeb M, Frassanito M, et al. The small subunit of Hemilipin2, a new heterodimeric phospholipase A2 from Hemiscorpius lepturus scorpion venom, mediates the antiangiogenic effect of the whole protein. Toxicon. 2017;126:38-46 pubmed publisher
    In a previous study, we reported the identification of Hemilipin, the first secreted heterodimeric phospholipase A2 (sPLA2) from Hemiscorpius lepturus scorpion venom and demonstrated its effective inhibition of all angiogenesis key steps ..
  65. Zhang S, Shao D, Liu H, Feng J, Feng B, Song X, et al. Metabolomics analysis reveals that benzo[a]pyrene, a component of PM2.5, promotes pulmonary injury by modifying lipid metabolism in a phospholipase A2-dependent manner in vivo and in vitro. Redox Biol. 2017;13:459-469 pubmed publisher
    ..Mechanically, BaP (4?M) increased the phospholipase A2 (PLA2) activity at 4h as well as the mRNA level of Pla2g2a at 12h...
  66. Chidgey J, Fraser P, Aaronson P. Reactive oxygen species facilitate the EDH response in arterioles by potentiating intracellular endothelial Ca(2+) release. Free Radic Biol Med. 2016;97:274-284 pubmed publisher
    ..Inhibiting PLC, PLA2 or CYP450 2C9 each greatly reduced the carbachol-induced increase in EC [Ca(2+)]i and vasodilatation, but adding 10..
  67. Dantas R, Jorge A, Jorge R, Menezes R, Lima D, Torres A, et al. l-amino acid oxidase from Bothrops marajoensis causes nephrotoxicity in isolated perfused kidney and cytotoxicity in MDCK renal cells. Toxicon. 2015;104:52-6 pubmed publisher
    ..Previously, we studied the renal effect of the whole venom of Bothrops marajoensis and its phospholipase A2 (PLA2), but these effects could not to be attributed to PLA2...
  68. Bustillo S, García Denegri M, Gay C, Van de Velde A, Acosta O, Angulo Y, et al. Phospholipase A(2) enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis. Chem Biol Interact. 2015;240:30-6 pubmed publisher
    ..Surprisingly, a purified acidic phospholipase A2 (PLA2) from the same venom was found to increase this detaching activity of the SVMP on myoblasts...
  69. Chinnasamy S, Chinnasamy S, Muthusamy K. High-affinity selective inhibitor against phospholipase A2 (PLA2): a computational study. J Recept Signal Transduct Res. 2016;36:111-8 pubmed publisher
    b>Phospholipase A2 (PLA2) is the most abundant protein found in snake venom...
  70. Jong W, Vikström D, Houben D, van den Berg van Saparoea H, de Gier J, Luirink J. Application of an E. coli signal sequence as a versatile inclusion body tag. Microb Cell Fact. 2017;16:50 pubmed publisher
    ..coli TorA (ssTorA) did not promote targeting but rather directed high-level expression of the human proteins hEGF, Pla2 and IL-3 in IBs...
  71. Yang C, Lee I, Chi P, Cheng S, Hsiao L, Hsu C. TNF-? induces cytosolic phospholipase A2 expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2014;306:L543-51 pubmed publisher
    Cytosolic phospholipase A2 (cPLA2) plays a pivotal role in mediating agonist-induced arachidonic acid release for prostaglandin (PG) synthesis during inflammation triggered by tumor necrosis factor-? (TNF-?)...
  72. Arroyo C, Solano S, Herrera M, Segura Ã, Estrada R, Vargas M, et al. Lachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenom. Toxicon. 2015;103:99-105 pubmed publisher
    ..Consequently, the anti-BL antivenom was less effective neutralizing lethal, coagulant, defibrinogenating, PLA2, and myotoxic activities of B. asper venom...
  73. Jeong H, Yun H, Kim B, Lee E, Kwon H. Widdrol-induced lipolysis is mediated by PKC and MEK/ERK in 3T3-L1 adipocytes. Mol Cell Biochem. 2015;410:247-54 pubmed publisher
    ..The adenylyl cyclase inhibitor SQ-22536, PLA2 inhibitor dexamethasone, PI3K inhibitor wortmannin, and PKA inhibitor H-89, which were used to investigate the ..
  74. Gómez Betancur I, Pereañez J, Patiño A, Benjumea D. Inhibitory effect of pinostrobin from Renealmia alpinia, on the enzymatic and biological activities of a PLA2. Int J Biol Macromol. 2016;89:35-42 pubmed publisher
    ..the inhibitory ability of pinostrobin on the enzymatic, anticoagulant, myotoxic and edema-inducing activities of a PLA2 isolated from Crotalus durissus cumanensis venom. The compound displayed IC50 values of 1.76mM and 1...
  75. Ebrahimi M, Firuzi O, Miri R, Razzaghi Asl N, Ebadi A. Structural Insight into Binding Mode of 9-Hydroxy Aristolochic Acid, Diclofenac and Indomethacin to PLA2. Interdiscip Sci. 2018;10:400-410 pubmed publisher
    ..More affinity toward PLA2 might be envisaged through negatively charged moieties via interaction with Trp31, Lys34 and Lys69. ..
  76. Clark M, Ozgur L, Conway T, Dispoto J, Crooke S, Bomalaski J. Cloning of a phospholipase A2-activating protein. Proc Natl Acad Sci U S A. 1991;88:5418-22 pubmed
    Recently we have described the isolation and biochemical characterization of a phospholipase A2-activating protein (PLAP). We have cloned this protein and found it to be expressed as a 2.5-kilobase mRNA...
  77. Song C, Choi J, Kim D, Kim J. Enhanced secretory group II PLA2 activity in the tears of chronic blepharitis patients. Invest Ophthalmol Vis Sci. 1999;40:2744-8 pubmed
    b>Phospholipase A2 (PLA2) hydrolyzes phospholipids, one of the important constituents of human meibomian gland secretions...
  78. Aslan M, Kıraç E, Yilmaz O, Unal B, Konuk E, Ozcan F, et al. Effect of tauroursodeoxycholic acid on PUFA levels and inflammation in an animal and cell model of hepatic endoplasmic reticulum stress. Hum Exp Toxicol. 2017;:960327117734621 pubmed publisher
    ..b>Phospholipase A2 (PLA2), cyclooxygenase (COX), and prostaglandin E2 (PGE2) were measured in tissue and cell samples...
  79. Wang Y, Sherchan P, Huang L, Akyol O, McBride D, Zhang J. Multiple mechanisms underlying neuroprotection by secretory phospholipase A2 preconditioning in a surgically induced brain injury rat model. Exp Neurol. 2018;300:30-40 pubmed publisher
    ..b>Phospholipase A2 (PLA2) is the upstream enzyme which initiates the PLA2, 5-lipoxygenase (5-LOX) and leukotriene B4 (LTB4) ..
  80. Hamilton P, Kanigicherla D, Hanumapura P, Walz L, Kramer D, Fischer M, et al. Peptide GAM immunoadsorption therapy in primary membranous nephropathy (PRISM): Phase II trial investigating the safety and feasibility of peptide GAM immunoadsorption in anti-PLA2 R positive primary membranous nephropathy. J Clin Apher. 2017;: pubmed publisher
    ..Immunoadsorption is a relatively safe procedure for the extracorporeal removal of specific immunoglobulins without the need for medications...
  81. Seilhamer J, Randall T, Yamanaka M, Johnson L. Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung. DNA. 1986;5:519-27 pubmed
    Oligonucleotide probes synthesized using the published protein sequence for porcine pancreatic phospholipase A2 (PLA2; Puijk et al., 1977), were used to screen a cDNA library made from porcine pancreas...
  82. Svensson C, Yaksh T. The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annu Rev Pharmacol Toxicol. 2002;42:553-83 pubmed
    Intrathecal phospholipase A2 (PLA2) and cyclooxygenase-2 (COX-2), but not COX-1, inhibitors attenuate facilitated pain states generated by peripheral injury/inflammation and by direct activation of spinal glutamate and substance P ..
  83. Edwards S, Thompson D, Baker S, Wood S, Wilton D. The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism. Biochemistry. 2002;41:15468-76 pubmed
  84. Agassandian M, Miakotina O, Andrews M, Mathur S, Mallampalli R. Pseudomonas aeruginosa and sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARalpha-RXR. Biochem J. 2007;403:409-20 pubmed
    ..Ps. aeruginosa triggered secretion of the pro-inflammatory lipase, sPLA2 IB (phospholipase A2 IB), from lung epithelium. Ps...
  85. Kim K, Lee W, Kim E. Crystal structures of human peroxiredoxin 6 in different oxidation states. Biochem Biophys Res Commun. 2016;477:717-722 pubmed publisher
    ..In addition, Prx6 has Ca(2+)-independent phospholipase A2 (PLA2) activity. Thus far only the crystal structure of Prx in the oxidized state has been reported...
  86. Cai R, Huang R, Han J, Sun H, Sun J, Xia W, et al. Lipoprotein-associated Phospholipase A2 Is Associated with Risk of Mild Cognitive Impairment in Chinese Patients with Type 2 Diabetes. Sci Rep. 2017;7:12311 pubmed publisher
    ..tests, high sensitivity C reactive protein (hsCRP), interleukin-6 (IL-6), lipoprotein-associated Phospholipase A2 (Lp-PLA2) mass and activity were measured...
  87. Khazdair M, Ghorani V, Alavinezhad A, Boskabady M. Pharmacological effects of Zataria multiflora Boiss L. and its constituents, focus on their anti-inflammatory, antioxidant and immunomodulatory effects. Fundam Clin Pharmacol. 2017;: pubmed publisher
    ..The protective effects of Z. multiflora on serum levels of phospholipase A2 (PLA2) and total protein were showed...
  88. Lopes Pires M, Clarke S, Marcondes S, Gibbins J. Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling. PLoS ONE. 2017;12:e0186981 pubmed publisher
    ..The effects of LPS were associated with phosphorylation of Akt, ERK1/2 and PLA2 in stimulated platelets, and inhibitors of PI3-kinase, Akt and ERK1/2 reduced significantly LPS enhanced platelet ..
  89. Borges R, Lemke N, Fontes M. PLA2-like proteins myotoxic mechanism: a dynamic model description. Sci Rep. 2017;7:15514 pubmed publisher
    ..These methods and strategies can be applied to other proteins to help understand their mechanisms of action. ..
  90. Grataroli R, Dijkman R, Dutilh C, van der Ouderaa F, de Haas G, Figarella C. Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region. Eur J Biochem. 1982;122:111-7 pubmed
    ..human prophospholipase A2, a heptapeptide is released from the N-terminal part of the protein yielding active phospholipase A2 (EC 3.1.1.4)...
  91. Sartipy P, Bondjers G, Hurt Camejo E. Phospholipase A2 type II binds to extracellular matrix biglycan: modulation of its activity on LDL by colocalization in glycosaminoglycan matrixes. Arterioscler Thromb Vasc Biol. 1998;18:1934-41 pubmed
    We recently reported the presence of secretory, nonpancreatic phospholipase A2 type II (snpPLA2; EC 3.1.1.4) in human atherosclerotic arteries (Hurt-Camejo et al, Arterioscler Thromb Vasc Biol. 1997;17:300-309)...
  92. Irobi J, Nelis E, Meuleman J, Venken K, De Jonghe P, Van Broeckhoven C, et al. Exclusion of 5 functional candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3. Ann Hum Genet. 2001;65:517-29 pubmed
    ..3 and located within a 13 cM region flanked by markers D12S86 and D12S340. We previously excluded the human phospholipase A2 group 1B gene (PLA2G1B) as the disease causing gene...