PKC epsilon

Summary

Gene Symbol: PKC epsilon
Description: protein kinase C epsilon
Alias: PKCE, nPKC-epsilon, protein kinase C epsilon type
Species: human

Top Publications

  1. pmc Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
    Gautam Bhave
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:12480-5. 2003
  2. doi Protein kinase Cε regulates proliferation and cell sensitivity to TGF-1β of CD4+ T lymphocytes: implications for Hashimoto thyroiditis
    Prisco Mirandola
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Parma, 43126 Parma, Italy
    J Immunol 187:4721-32. 2011
  3. ncbi Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 144:3928-35. 1990
  4. ncbi HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta
    Yamina Bennasser
    Laboratoire d Immuno Virologie, EA 3038, Universite Paul Sabatier, 31062 Toulouse, France
    FASEB J 16:546-54. 2002
  5. ncbi Opposing effects of protein kinase Calpha and protein kinase Cepsilon on collagen expression by human lung fibroblasts are mediated via MEK/ERK and caveolin-1 signaling
    Elena Tourkina
    Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 280:13879-87. 2005
  6. ncbi A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Cell Immunol 137:1-13. 1991
  7. ncbi Phosphorylation of HIV-1 gag proteins by protein kinase C
    B Burnette
    Laboratory of Biological Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:8698-703. 1993
  8. ncbi Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine 92717
    Int J Immunopharmacol 16:197-204. 1994
  9. pmc Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
    K Conant
    Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    J Virol 70:1384-9. 1996
  10. ncbi In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46
    A M Holmes
    Biochemistry Department, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Arch Biochem Biophys 335:8-12. 1996

Research Grants

  1. Propofol and Protein Kinase C: Molecular Interactions in Cardiomyocytes
    DEREK SCOTT DAMRON; Fiscal Year: 2011
  2. Extinction is mediated by the infralimbic cortex and protein kinase C epsilon
    Philip M Newton; Fiscal Year: 2010
  3. The role of PKCepsilon in diabetic retinopathy
    Christian Rask-Madsen; Fiscal Year: 2012
  4. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2009
  5. Robert O Messing; Fiscal Year: 2016
  6. Preclinical Development of Selective PKC_epsilon Inhibitors to Treat Alcoholism
    JAY JIE QIANG WU; Fiscal Year: 2013
  7. R John Solaro; Fiscal Year: 2016
  8. HERB-INDUCED OXIDANT PRECONDITIONING IN CARDIOMYOCYTES
    Zuo Hui Shao; Fiscal Year: 2010
  9. PKC-e Mechanisms in Acute and Chronic Pain
    JON DAVID LEVINE; Fiscal Year: 2011
  10. Control of Ethanol Intake by an mGluR5-PKCe Pathway
    M Foster Olive; Fiscal Year: 2013

Scientific Experts

Detail Information

Publications163 found, 100 shown here

  1. pmc Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
    Gautam Bhave
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:12480-5. 2003
    ..Furthermore, modulation of the TRPV1 function by PKC appears to involve distinct phosphorylation sites depending on the mechanism of channel activation...
  2. doi Protein kinase Cε regulates proliferation and cell sensitivity to TGF-1β of CD4+ T lymphocytes: implications for Hashimoto thyroiditis
    Prisco Mirandola
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Parma, 43126 Parma, Italy
    J Immunol 187:4721-32. 2011
    ....
  3. ncbi Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 144:3928-35. 1990
    ....
  4. ncbi HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta
    Yamina Bennasser
    Laboratoire d Immuno Virologie, EA 3038, Universite Paul Sabatier, 31062 Toulouse, France
    FASEB J 16:546-54. 2002
    ..Altogether, these results suggest that the induction of IL-10 by Tat is strictly dependent on the PKC-delta and -betaII isoforms...
  5. ncbi Opposing effects of protein kinase Calpha and protein kinase Cepsilon on collagen expression by human lung fibroblasts are mediated via MEK/ERK and caveolin-1 signaling
    Elena Tourkina
    Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 280:13879-87. 2005
    ..The combined results demonstrate that a branched signaling pathway involving MEK, ERK, PKCepsilon, PKCalpha, and caveolin-1 regulates collagen expression in normal lung tissue and is perturbed during fibrosis...
  6. ncbi A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Cell Immunol 137:1-13. 1991
    ....
  7. ncbi Phosphorylation of HIV-1 gag proteins by protein kinase C
    B Burnette
    Laboratory of Biological Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:8698-703. 1993
    ..These data are consistent with the identification of a highly conserved consensus PKC phosphorylation site motif in the HIV-1 gag protein at Ser111 and suggests that PKC phosphorylation plays an important role in gag protein function...
  8. ncbi Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine 92717
    Int J Immunopharmacol 16:197-204. 1994
    ..The most striking change was observed in PKC-zeta isozymes levels. This study for the first time demonstrates that HIV-1 gp120 affects calcium-independent PKC isozymes in U937 cells...
  9. pmc Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
    K Conant
    Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    J Virol 70:1384-9. 1996
    ..These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor...
  10. ncbi In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46
    A M Holmes
    Biochemistry Department, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Arch Biochem Biophys 335:8-12. 1996
    ..Several Tat peptides, containing serine at position 46, are the only ones which are phosphorylated at significant rates. Several other Tat peptides containing potential protein kinase C phosphorylation sites are not phosphorylated...
  11. pmc Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway
    A Badou
    Laboratoire d Immuno Virologie EA3038, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    J Virol 74:10551-62. 2000
    ..This production of IL-10 induced by Tat could participate in the progression of HIV infection to AIDS...
  12. ncbi Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium
    M B Huang
    Department of Biochemistry, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Acquir Immune Defic Syndr 25:375-89. 2000
    ....
  13. pmc HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?
    Giuseppe Nunnari
    University of Catania, Department of Medicine and Medical Specialties, Division of Infectious Diseases, Via Palermo 636, Catania, Italy
    J Exp Clin Cancer Res 27:3. 2008
    ..We propose that the Tat-induced DNA repair deficiencies may play a significant role in the development of AIDS-associated cancer...
  14. pmc Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association
    Janis L Watkins
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:18378-83. 2008
    ..Thus, 2 arms of the PKC pathway regulate interactions between Par-1b and 14-3-3 proteins: one involving aPKC and the other nPKC/PKD...
  15. ncbi Regulation of HIV-1 gag protein subcellular targeting by protein kinase C
    G Yu
    Laboratory of Biological Chemistry, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255
    J Biol Chem 270:4792-6. 1995
    ..This signal may provide a mechanism for the cellular regulation of virus development through modulation of gag protein-related developmental steps such as capsid targeting, assembly, encapsidation, budding, and maturation...
  16. pmc The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix
    S Swingler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 71:4372-7. 1997
    ..Recombinant p21-activated kinase hPAK65, a recently proposed relative of the Nef-associated kinase, achieved a comparable result. Taken together, these data suggest that MA is a target of the Nef-associated serine kinase...
  17. ncbi HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system
    H Idriss
    Sealy Center for Molecular Science, The University of Texas Medical Branch Galveston, TX 77555 0851, USA
    Int J Biochem Cell Biol 31:1443-52. 1999
    ..Our results indicate that purified HIV-1 RT can be phosphorylated by several mammalian protein kinases in vitro and during expression in baculovirus infected insect cells...
  18. pmc Galectin-1 is implicated in the protein kinase C epsilon/vimentin-controlled trafficking of integrin-beta1 in glioblastoma cells
    Shannon Fortin
    Laboratory of Toxicology, Institute of Pharmacy, Univesité Libre de Bruxelles, Brussels
    Brain Pathol 20:39-49. 2010
    ..The understanding of molecular mediators such as galectin-1 and the pathways through which they drive the cell invasion so descriptive of GBM is anticipated to reveal potential therapeutic targets that promote glioma malignancy...
  19. pmc PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18
    M B Omary
    Stanford University School of Medicine, Gastroenterology Division, California 94305
    J Cell Biol 117:583-93. 1992
    ..Immunoblot analysis of CK8/18 immunoprecipitates using an anti-PKC epsilon specific antibody showed that the 40-kD species, and not native PKC epsilon (90 kD) associated with the ..
  20. pmc Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC
    L Chen
    Division of Chemical Biology, Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 98:11114-9. 2001
    ..Moreover, reduction in cardiac damage caused by ischemia by perfusion of selective regulator peptides of PKC through the coronary arteries constitutes a major step toward developing a therapeutic agent for acute cardiac ischemia...
  21. pmc Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection
    A Castrillo
    Instituto de Bioquímica Centro Mixto Consejo Superior de Investigaciones Cientificas UCM, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
    J Exp Med 194:1231-42. 2001
    ..Furthermore, we demonstrate that in the absence of PKCepsilon, host defense against bacterial infection is severely compromised, resulting in an increased incidence of mortality...
  22. ncbi Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases
    David Crosby
    Department of Pharmacology, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 277:9958-65. 2002
    ..We propose a reciprocal feedback interaction between Btk and PKCtheta; in platelets, in which PKCtheta; positively modulates activity of Btk, which in turn feeds back negatively upon PKCtheta;...
  23. ncbi The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility
    Arnaud Besson
    Department of Oncology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 277:22073-84. 2002
    ..Altogether, these results provide a novel mechanistic link between PKC activation and integrin-mediated adhesion and motility...
  24. ncbi Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells
    Daqing Wu
    Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
    Oncogene 23:8659-72. 2004
    ....
  25. pmc PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice
    Doo Sup Choi
    Ernest Gallo Clinic and Research Center, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 103:8215-20. 2006
    ..These results indicate that increased neuronal PKCepsilon activity can promote Abeta clearance and reduce AD neuropathology through increased endothelin-converting enzyme activity...
  26. ncbi Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death
    Dongmei Lu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 281:22799-807. 2006
    ..These results suggest that PKCepsilon activates Akt via DNA-PK to mediate its antiapoptotic function. Furthermore, we report for the first time that DNA-PK can regulate receptor-initiated apoptosis via Akt...
  27. pmc Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma
    Quintin Pan
    Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Cancer Res 66:9379-84. 2006
    ..In this study, we determine the downstream signaling pathway mediated by PKC epsilon to promote an aggressive HNSCC phenotype...
  28. ncbi Timing and expression level of protein kinase C epsilon regulate the megakaryocytic differentiation of human CD34 cells
    Giuliana Gobbi
    Department of Anatomy, Pharmacology and Forensic Medicine, Human Anatomy Section, University of Parma, Ospedale Maggiore, Via Gramsci, 14, I 43100 Parma, Italy
    Stem Cells 25:2322-9. 2007
    ....
  29. ncbi Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner
    Kyung Mi Bae
    University of Florida Shands Cancer Center, University of Florida College of Medicine, Gainesville, Florida 32610 3633, USA
    Cancer Res 67:6053-63. 2007
    ..In this study, we showed for the first time by immunohistochemistry that overexpression of PKC epsilon was detected in the vast majority (>90%) of primary human non-small cell lung cancers (NSCLC) compared with ..
  30. ncbi Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers
    Takuya Suzuki
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 283:3574-83. 2008
    ..This study shows that PLCgamma-mediated activation of PKCepsilon and PKCbetaI and intracellular calcium is involved in EGF-mediated protection of tight junctions from acetaldehyde-induced insult...
  31. pmc Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1
    Irina Gorshkova
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 283:11794-806. 2008
    ..Activation of this pathway is necessary to stimulate the migration of lung endothelial cells, a key component of the angiogenic process...
  32. doi The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis
    Adrian T Saurin
    Protein Phosphorylation Laboratory, London Research Institute, Cancer Research UK, London, WC2A 3PX, UK
    Nat Cell Biol 10:891-901. 2008
    ..This study therefore identifies a new regulatory mechanism that controls exit from cytokinesis, which has implications for carcinogenesis...
  33. doi Phorbol ester-induced PKCepsilon down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation
    Giuliana Gobbi
    Department of Anatomy, Pharmacology and Forensic Medicine, Human Anatomy Section, University of Parma, Ospedale Maggiore, Parma, Italy
    Blood 113:3080-7. 2009
    ..We believe that the use of TRAIL in combination with phorbol esters (or possibly more specific PKCepsilon down-modulators) might represent a significative improvement of our therapeutic arsenal against AML...
  34. pmc Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets
    Catherine J Pears
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 3:e3793. 2008
    ..Increasing evidence suggests that individual isoforms of protein kinase C (PKC) play distinct roles in regulating platelet activation...
  35. doi miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon
    Paolo Gandellini
    Department of Experimental Oncology and Laboratories, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy
    Cancer Res 69:2287-95. 2009
    ....
  36. pmc Protein kinase C epsilon is involved in ionizing radiation induced bystander response in human cells
    Burong Hu
    Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, 630 West, 168th Street, VC 11, Room 239, Columbia University, New York, NY 10032, USA
    Int J Biochem Cell Biol 41:2413-21. 2009
    ..In this study, we extended our investigation to yet another important member of PKC family, PKC epsilon (PKCepsilon)...
  37. pmc Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy res
    Lilly Y W Bourguignon
    Endocrine Unit, Department of Medicine, University of California at San Francisco, and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 284:26533-46. 2009
    ..Thus, this newly discovered HA-CD44 signaling pathway should provide important drug targets for sensitizing tumor cell apoptosis and overcoming chemotherapy resistance in breast cancer cells...
  38. pmc The substrates and binding partners of protein kinase Cepsilon
    Philip M Newton
    Swansea University, Wales, UK
    Biochem J 427:189-96. 2010
    ....
  39. pmc Intracellular interaction of interleukin (IL)-32α with protein kinase Cε (PKCε ) and STAT3 protein augments IL-6 production in THP-1 promonocytic cells
    Jeong Woo Kang
    Department of Bioscience and Biotechnology, Bio Molecular Informatics Center, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, Korea
    J Biol Chem 287:35556-64. 2012
    ..Thus, our data indicate that the intracellular interaction of IL-32α with PKCε and STAT3 promotes STAT3 binding to the IL-6 promoter by enforcing STAT3 phosphorylation, which results in increased production of IL-6...
  40. pmc A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin
    Saara Hämälistö
    Center for Biotechnology, University of Turku, Turku, Finland
    PLoS ONE 8:e70696. 2013
    ..Altogether, our results identify a novel regulatory pathway involving the interplay between ZO-1, α5-integrin and PKCε in the late stages of mammalian cell division. ..
  41. ncbi HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes
    I W Park
    Division of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Blood 97:352-8. 2001
    ..These data indicate that the HIV-1 Tat protein may act as a protocytokine by causing the release of MCP-1 from the endothelial monolayer, and thereby facilitating monocyte transmigration into tissues via a PKC signaling pathway...
  42. ncbi Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts
    Souvenir D Tachado
    Department of Anatomy and Cell Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27858, USA
    J Cell Biochem 85:785-97. 2002
    ..We propose that PKCepsilon directly interacts with actin to stimulate polymerization and the extension of membrane protrusions that transformed NIH3T3 cells use in vivo to penetrate and degrade surrounding tissue boundaries...
  43. ncbi Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells
    Meagan A McJilton
    Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
    Oncogene 22:7958-68. 2003
    ..Considered in their entirety, our data suggest that an association of PKCepsilon with Bax may neutralize apoptotic signals propagated through a mitochondrial death-signaling pathway...
  44. ncbi Evidence that insulin-like growth factor-1 requires protein kinase C-epsilon, PI3-kinase and mitogen-activated protein kinase pathways to protect human vascular smooth muscle cells from apoptosis
    Todd R Allen
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Immunol Cell Biol 83:651-67. 2005
    ..These results indicate for the first time that IGF-1 can protect human VSMC via multiple signals, including PKC-epsilon, PI3-K and mitogen-activated protein kinase pathways...
  45. ncbi Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway
    Li Ding
    University of Florida Shands Cancer Center and Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 277:35305-13. 2002
    ..Taken together, our findings suggest an important role for PKC-epsilon in regulating survival of lung cancer cells...
  46. doi Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta
    G Frangioudakis
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales, 2010, Australia
    Diabetologia 52:2616-20. 2009
    ....
  47. ncbi Regulation of expression and activity of four PKC isozymes in confluent and mechanically stimulated UMR-108 osteoblastic cells
    W D Geng
    Department of Physiology, Marshall University School of Medicine, Huntington, West Virginia 25704, USA
    J Cell Physiol 189:216-28. 2001
    ..1994. J Bone Miner Res 9(7):999-1011) that PKC could be involved in the early phase of mechanotransduction in osteoblasts through the activation of focal adhesion assembly/disassembly and the remodeling of the actin cytoskeleton...
  48. pmc Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility
    Rebecca L Zuvich
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232 0700, USA
    Hum Genet 127:525-35. 2010
    ..2009). These results help to further delineate the genetic architecture of MS and validate our pathway approach as an effective method to identify novel associations in a complex disease...
  49. doi Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver
    R Wimmer
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany
    Gut 57:1448-54. 2008
    ..We tested whether protein kinase A (PKA) might contribute to the anticholestatic action of TUDCA via cooperative cPKC alpha-/PKA-dependent mechanisms in taurolithocholic acid (TLCA)-induced cholestasis...
  50. ncbi Protein kinase C isoforms involved in the transcriptional activation of cyclin D1 by transforming Ha-Ras
    S Kampfer
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, A-6020 Innsbruck, Austria
    J Biol Chem 276:42834-42. 2001
    ..Evidence is presented that aPKC-lambda acts upstream of Rac, between Ras and Rac, whereas the PKC isotypes epsilon and zeta act downstream of Rac and are required for the activation of ERKs...
  51. doi Inhibition of PKCgamma membrane translocation mediated morphine preconditioning-induced neuroprotection against oxygen-glucose deprivation in the hippocampus slices of mice
    Ya Liu
    Department of Anesthesiology, Capital Medical University Affiliated Beijing Tongren Hospital, Beijing 100730, China
    Neurosci Lett 444:87-91. 2008
    ..These results demonstrated that MP can reduce OGD-induced neuronal injuries, and the down-regulation of cPKCgamma membrane translocation might be involved in the neuroprotection...
  52. pmc Fetal exposure to cocaine causes programming of Prkce gene repression in the left ventricle of adult rat offspring
    Haitao Zhang
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California, USA
    Biol Reprod 80:440-8. 2009
    ....
  53. pmc Role of protein kinase C isozymes in the regulation of alpha1-adrenergic receptor-mediated contractions in ovine uterine arteries
    Hongying Zhang
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Biol Reprod 78:35-42. 2008
    ....
  54. doi Grape and wine polyphenols down-regulate the expression of signal transduction genes and inhibit the growth of estrogen receptor-negative MDA-MB231 tumors in nu/nu mouse xenografts
    Fatima Hakimuddin
    Department of Food Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Nutr Res 28:702-13. 2008
    ..The study highlights the potential influences of dietary polyphenolic components on gene expression in estrogen receptor-negative tumors and its relation to inhibition of tumor growth...
  55. ncbi The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C
    T Herget
    Institute of Physiological Chemistry, University of Mainz, Germany
    Eur J Biochem 233:448-57. 1995
    ..Conventional (c)PKC beta 1, novel (n)PKC delta and nPKC epsilon efficiently phosphorylated the MARCKS protein in vitro...
  56. ncbi Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta
    K Mizuno
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Eur J Biochem 202:931-40. 1991
    ..in a phorbol-ester- or diacylglycerol-dependent manner, like conventional protein kinase C (cPKC) isozymes and nPKC epsilon. However, nPKC delta, like nPKC epsilon, is not activated by Ca2+, a known activator of cPKCs, and requires ..
  57. ncbi A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin
    S Osada
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    J Biol Chem 265:22434-40. 1990
    ..nPKC eta shows the highest sequence similarity to nPKC epsilon (59.4% identity)...
  58. ncbi Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a
    H Wada
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Biochem Biophys Res Commun 165:533-8. 1989
    ..Human lymphoid cell lines express large amounts of PKC beta mRNAs in addition to PKC alpha. Further, nPKC epsilon mRNA is expressed in some of these cell lines...
  59. ncbi Mechanisms of gender-specific TCDD-induced toxicity in guinea pig adipose tissue
    E Enan
    Department of Environmental Toxicology and Institute of Toxicology and Environmental Health, University of California, Davis 95616, USA
    Reprod Toxicol 12:357-69. 1998
    After treatment with TCDD, the activities of cytosolic AhR-associated c-Src kinase, microsomal protein kinase C (nPKC epsilon), microsomal c-Src kinase, nuclear p44/42 MAPK, c-Jun N terminus kinase, and the amount of microsomal pan-Ras ..
  60. ncbi Activations of nPKCepsilon and ERK1/2 were involved in oxygen-glucose deprivation-induced neuroprotection via NMDA receptors in hippocampal slices of mice
    Jun Jia
    Department of Physiology, Institute for Biomedical Science of Pain, Capital Medical University, Beijing 100069, China
    J Neurosurg Anesthesiol 19:18-24. 2007
    ..These results suggest that OGD10-induced neuroprotection against severe OGD45 in the Cornu Ammonis region 1 region of the hippocampal slices was mediated by the activations of NMDA receptors, nPKCepsilon, and the downstream ERKs...
  61. doi Protein kinase C isoforms in the porcine corpus luteum: temporal and spatial expression patterns
    L M Zorrilla
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St, Raleigh, NC 27606, USA
    Domest Anim Endocrinol 36:173-85. 2009
    ..In conclusion, since the increase in PRKCE protein expression (day 13) occurred coincidentally with the onset of LS (> or =day 12), these results support a potential role for PRKCE in control of the acquisition of LS in the pig...
  62. pmc Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours
    Petra Gromova
    Laboratory of Neurophysiology, Faculty of Medicine, Universite Libre de Bruxelles ULB, Brussels, Belgium
    J Cell Mol Med 13:1536-48. 2009
    ..Gja1/Cx43, Gpc6, Gpr133, Pacrg, Pde3a, Prkar2b, Prkcq/Pkce, Rasd2, Spry4 and Tpbg/5T4 were found to be up-regulated...
  63. ncbi Long-term pioglitazone treatment augments insulin sensitivity and PKC-epsilon and PKC-theta activation in skeletal muscles in sucrose fed rats
    I Markova
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Physiol Res 59:509-16. 2010
    ....
  64. ncbi Zeta PKC in rat preadipocytes: modulation by insulin and serum mitogenic factors and possible role in adipogenesis
    D Lacasa
    Department of Biochemistry, INSERM CJF 94-02, , , France
    Biochem Biophys Res Commun 217:123-30. 1995
    Several PKC isoforms belonging to the three PKCs' subfamilies cPKC alpha and beta isoforms, nPKC epsilon isoform and aPKC zeta isoform were detected by Western blot in rat preadipocytes...
  65. ncbi miR-129 regulates cell proliferation by downregulating Cdk6 expression
    Junjie Wu
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Cell Cycle 9:1809-18. 2010
    ..Together, our data indicate that miR-129 plays an important role in regulating cell proliferation by downregulation of Cdk6...
  66. pmc Analysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinome
    Sami Kilpinen
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    PLoS ONE 5:e15068. 2010
    ....
  67. ncbi Protein kinase C-epsilon mediates phorbol ester-induced phosphorylation of connexin-43
    B W Doble
    Institute of Cardiovascular Sciences and Department of Human Anatomy, University of Manitoba, Winnipeg, Canada
    Cell Commun Adhes 8:253-6. 2001
    ..Selective inhibition of PKCE significantly decreased baseline levels of Cx43 phosphorylation and the PMA-induced accumulation of > or = 45 ..
  68. doi GH3B6 pituitary tumor cell proliferation is mediated by PKCalpha and PKCepsilon via ERK 1/2-dependent pathway
    Juan Pablo Petiti
    Centro de Microscopia Electronica, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Cell Physiol Biochem 26:135-46. 2010
    In this report, we explored the role of PKCalpha and PKCe as mediators of phorbol 12-myristate13-acetate (PMA)-induced proliferation in pituitary tumor GH3B6 cells, and determined if the ERK1/2 and Akt pathways were activated.
  69. ncbi The signaling mechanism of the sphingosylphosphorylcholine-induced contraction in cat esophageal smooth muscle cells
    Yong Sung Kim
    College of Pharmacy, Chung Ang University, Seoul 156 756, Korea
    Arch Pharm Res 30:1608-18. 2007
    ..smooth muscle cells depends on activation of the G(i1), G(i2), G(i3) and G(o) proteins and the PLCbeta3 isozyme via the S1P2 receptor, leading to stimulation of a PKCE pathway, which subsequently activates a p44/p42 MAPK pathway.
  70. pmc Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C
    A Jakobovits
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    EMBO J 9:1165-70. 1990
    ..Our results indicate that PKC regulates the process of HIV-1 transactivation, suggesting a key role for the mitogenic induction of trans-activation in the transition of HIV from latency to productive growth...
  71. ncbi Protein-protein interaction of zinc finger LIM domains with protein kinase C
    S Kuroda
    Biosignal Research Center, Kobe University, Kobe 657, Japan
    J Biol Chem 271:31029-32. 1996
    ..These results suggest that the LIM domain is one of the targets of PKC and that the LIM-PKC interaction may shed light on undefined roles of LIM domain-containing proteins...
  72. ncbi Calponin and mitogen-activated protein kinase signaling in differentiated vascular smooth muscle
    C B Menice
    Signal Transduction Group, Boston Biomedical Research Institute, Boston, Massachusetts 02114, USA
    J Biol Chem 272:25157-61. 1997
    ..These results suggest a role for calponin as a signaling molecule, possibly an adapter protein, linking the targeting of mitogen-activated protein kinase and protein kinase C-epsilon to the surface membrane...
  73. ncbi The pleckstrin homology domain of protein kinase D interacts preferentially with the eta isoform of protein kinase C
    R T Waldron
    Department of Medicine, School of Medicine and Molecular Biology Institute, University of California, Los Angeles, California 90095 1786, USA
    J Biol Chem 274:9224-30. 1999
    ..g. novel PKCs epsilon and eta, thereby revealing a previously undetected degree of specificity among protein-protein interactions mediated by PH domains...
  74. ncbi Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates
    J Tozser
    Department of Biochemistry and Molecular Biology, University Medical School of Debrecen, Hungary
    Eur J Biochem 265:423-9. 1999
    ....
  75. ncbi Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation
    N Ilan
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 275:21435-43. 2000
    ..These data further support the concept that PECAM-1 functions as a binder and modulator of catenins and provides a molecular mechanism for previously reported PECAM-1/cytoskeleton interactions...
  76. ncbi Regulation of caveolin-1 expression and secretion by a protein kinase cepsilon signaling pathway in human prostate cancer cells
    Daqing Wu
    Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
    J Biol Chem 277:40449-55. 2002
    ..Our findings support the hypothesis that PKCepsilon may advance the recurrence of human prostate cancer by promoting the expression of several important downstream effectors of disease progression...
  77. ncbi Protein kinase C(mu) regulation of the JNK pathway is triggered via phosphoinositide-dependent kinase 1 and protein kinase C(epsilon)
    Ilona Brändlin
    Fraunhofer Institute for Interfacial Engineering, Nobelstrabetae 12, 70569 Stuttgart, Germany
    J Biol Chem 277:45451-7. 2002
    ..In this study, we show that differentially activated kinase cascades involving PDK1 and novel PKC isotypes are responsible for the regulation of PKC(mu) activity and consequently inhibit the JNK pathway...
  78. ncbi Platelet P-selectin expression: requirement for protein kinase C, but not protein tyrosine kinase or phosphoinositide 3-kinase
    Danielle Libersan
    Montreal Heart Institute and the University of Montreal, Quebec, Canada
    Thromb Haemost 89:1016-23. 2003
    ..The novel epsilon and eta and atypical zeta, but not the conventional alpha and beta and the novel delta PKCs, may be involved in this process...
  79. ncbi PKC epsilon is a unique regulator for hsp90 beta gene in heat shock response
    Jian Min Wu
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    J Biol Chem 278:51143-9. 2003
    ..We conclude that PKC-epsilon is specifically required in the signaling pathway leading to the induction of hsp90 beta gene in response to heat shock...
  80. ncbi Protein kinase C isoforms differentially phosphorylate human choline acetyltransferase regulating its catalytic activity
    Tomas Dobransky
    Department of Physiology, University of Western Ontario and Cell Biology Research Group, and Robarts Research Institute, London, Ontario N6A 5C1, Canada
    J Biol Chem 279:52059-68. 2004
    ..Finally, basal ChAT phosphorylation in neurons is mediated predominantly by PKC at Ser-476, with PKC activation increasing phosphorylation at Ser-440 and enhancing ChAT activity...
  81. ncbi IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes
    Xavier Contreras
    Laboratoire d Immuno Virologie des Lentivirus des Primates, EA3038, Universite Paul Sabatier, 118, route de Narbonne, 31062 Toulouse, France
    Microbes Infect 6:1182-90. 2004
    ....
  82. ncbi IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner
    Zhigang Li
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:13871-8. 2005
    ..Our data disclose that IQGAP1 is phosphorylated at multiple sites in intact cells and that phosphorylation of IQGAP1 will alter its ability to regulate the cytoskeleton of neuronal cells...
  83. ncbi Variable expression of protein kinase C epsilon in human melanoma cells regulates sensitivity to TRAIL-induced apoptosis
    Susan Gillespie
    Immunology and Oncology Unit, Newcastle Mater Hospital, Room 443, David Maddison Clinical Sciences Building, Corner King and Watt Streets, Newcastle, New South Wales 2300, Australia
    Mol Cancer Ther 4:668-76. 2005
    ..PMA) led to inhibition of apoptosis in the majority of the melanoma cell lines, but those with relatively low PKC epsilon expression were sensitized to TRAIL-induced apoptosis...
  84. pmc Detailed protein sequence alignment based on Spectral Similarity Score (SSS)
    Kshitiz Gupta
    Department of Computer Science and Engineering, Indian Institute of Technology, Bombay, Mumbai, India
    BMC Bioinformatics 6:105. 2005
    ..This approach finds a similarity score between sequences based on any given attribute, like hydrophobicity of amino acids, on the basis of spectral information after partial conversion to the frequency domain...
  85. ncbi Sphingosine 1-phosphate-induced signal transduction in cat esophagus smooth muscle cells
    Hyun Ju Song
    Department of Pharmacology, College of Pharmacy, Chung Ang University, Seoul 156 756, Korea
    Mol Cells 21:42-51. 2006
    ..Since PKCepsilon antibody inhibited contraction, PKCe may be required...
  86. pmc Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice
    Silvia Amadesi
    Department of Surgery, University of California, San Francisco, Room C317, 521 Parnassus Avenue, San Francisco, CA 94143 0660, USA
    J Physiol 575:555-71. 2006
    ..Thus, PAR2 activates PKCepsilon and PKA in sensory neurons, and thereby sensitizes TRPV1 to cause thermal hyperalgesia. These mechanisms may underlie inflammatory pain, where multiple proteases are generated and released...
  87. pmc FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2
    Olivier E Pardo
    Lung Cancer Biology Group, Cancer Research UK, Imperial College London, Hammersmith Hospitals Campus, Du Cane Road, London, UK
    EMBO J 25:3078-88. 2006
    ..However, increased S6K1 kinase activity has no such effect. Thus, S6K2 but not S6K1 mediates prosurvival/chemoresistance signalling...
  88. pmc Protein kinase C alpha and epsilon differentially modulate hepatocyte growth factor-induced epithelial proliferation and migration
    Guru Dutt Sharma
    Department of Ophthalmology and Neuroscience Center of Excellence, LSU Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Exp Eye Res 85:289-97. 2007
    ....
  89. doi Differential regulation of Moraxella catarrhalis-induced interleukin-8 response by protein kinase C isoforms
    H Slevogt
    Dept of Internal Medicine Infectious Diseases and Respiratory Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur Respir J 31:725-35. 2008
    ..In conclusion, it was shown that Moraxella catarrhalis infection activates protein kinase C and its isoforms alpha, epsilon and theta, which differentially regulate interleukin-8 transcription in human pulmonary epithelial cells...
  90. doi Site-specific regulation of gene expression by estrogen in the hypothalamus of adult female rats
    Qing Xu
    Department of Physiology, Nippon Medical School, 1 1 1 Sendagi, Bunkyo, Tokyo 113 8602, Japan
    Neurosci Lett 436:35-9. 2008
    ....
  91. doi The scaffold MyD88 acts to couple protein kinase Cepsilon to Toll-like receptors
    Amir Faisal
    Protein Phosphorylation Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, United Kingdom
    J Biol Chem 283:18591-600. 2008
    ..This study therefore identifies the scaffold protein MyD88 as the link coupling TLRs to PKCepsilon recruitment, phosphorylation, and downstream signaling...
  92. pmc Role of PKCepsilon in PGF2alpha-stimulated MMP-2 secretion from human ciliary muscle cells
    Shahid Husain
    Department of Ophthalmology, Hewitt Laboratory of the Ola B Williams Glaucoma Center, Medical University of South Carolina, Charleston, SC 29425, USA
    J Ocul Pharmacol Ther 24:268-77. 2008
    ..These data support the idea that the activation of FP receptors in vivo modulate uveoscleral outflow through the PKCepsilon-dependent secretion of MMPs...
  93. doi The downregulation of onzin expression by PKCepsilon-ERK2 signaling and its potential role in AML cell differentiation
    S F Wu
    Institute of Health Science, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences Shanghai Jiaotong University School of Medicine SJTU SM, Shanghai, China
    Leukemia 24:544-51. 2010
    ..1 via their interaction. Taken together, our results show that PMA downregulates onzin expression through PKCepsilon-ERK2 signaling pathway, which favors monocytic differentiation of leukemic cells...
  94. pmc Protection from rapamycin-induced apoptosis by insulin-like growth factor-I is partially dependent on protein kinase C signaling
    Kuntebommanahalli N Thimmaiah
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer Res 70:2000-9. 2010
    ..Collectively, these data suggest that IGF-I-induced phosphorylation of Bad at multiple sites via a pathway involving PI3K and PKCs is important for protecting sarcoma cells from rapamycin-induced apoptosis...
  95. doi Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice
    K Raddatz
    Garvan Institute of Medical Research, 384 Victoria Street, Sydney, NSW 2010, Australia
    Diabetologia 54:1447-56. 2011
    ..We examined the time-dependent effects of deletion of the gene encoding protein kinase C epsilon (Prkce) on glucose homeostasis, insulin secretion and hepatic lipid metabolism in fat-fed mice...
  96. pmc TACE/ADAM-17 phosphorylation by PKC-epsilon mediates premalignant changes in tobacco smoke-exposed lung cells
    Hassan Lemjabbar-Alaoui
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e17489. 2011
    ....
  97. pmc Association study of 167 candidate genes for schizophrenia selected by a multi-domain evidence-based prioritization algorithm and neurodevelopmental hypothesis
    Zhongming Zhao
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS ONE 8:e67776. 2013
    ..As such, further development of gene ranking strategies using more carefully selected sources of information is warranted...
  98. doi CK8 phosphorylation induced by compressive loads underlies the downregulation of CK8 in human disc degeneration by activating protein kinase C
    Zhen Sun
    Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi an, People s Republic of China
    Lab Invest 93:1323-30. 2013
    ..Importantly, our findings provide clues regarding a molecular link between compressive loads and CK8 alterations, which shed a novel light on the etiology of IDD...
  99. pmc MiR-34a regulates blood-tumor barrier function by targeting protein kinase Cε
    Wei Zhao
    Department of Neurobiology, China Medical University, Shenyang 110122, China Department of Physiology, College of Basic Medicine, China Medical University, Shenyang 110122, China
    Mol Biol Cell 26:1786-96. 2015
    ....
  100. pmc IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity
    S Kumar
    Laboratory of Immunology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India
    Cell Death Dis 6:e1758. 2015
    ....
  101. pmc Identification and characterization of lncRNA mediated transcriptional dysregulation dictates lncRNA roles in glioblastoma
    Yongsheng Li
    College of Bioinformatics Science and Technology and Bio pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, China
    Oncotarget 7:45027-45041. 2016
    ..The integration of lncRNA modulators into transcriptional regulatory networks will further enhance our understanding of lncRNA functions in cancer...

Research Grants40

  1. Propofol and Protein Kinase C: Molecular Interactions in Cardiomyocytes
    DEREK SCOTT DAMRON; Fiscal Year: 2011
    ..Activation of protein kinase C epsilon (PKCe) has been shown to play a key role in mediating anesthesia-induced myocardial protection, however the cellular and ..
  2. Extinction is mediated by the infralimbic cortex and protein kinase C epsilon
    Philip M Newton; Fiscal Year: 2010
    ..We are currently funded by the US Department of Defense to determine where in the brain PKCe acts to control behavior in a mouse model of PTSD...
  3. The role of PKCepsilon in diabetic retinopathy
    Christian Rask-Madsen; Fiscal Year: 2012
    ..In preliminary results, downregulation of PKCe with small interfering RNA (siRNA) in endothelial cell culture had a dramatic effect on several pathways of VEGF-..
  4. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2009
    ..the oxidative stress-induced disruption of tight junctions;this process involved signaling molecules, PLCg, PKCbI, PKCe and MAP kinases...
  5. Robert O Messing; Fiscal Year: 2016
    ..Because of its focus on identifying new drug targets and pharmacological agents to treat alcohol use disorders, this project has high translational value for serving public health. ..
  6. Preclinical Development of Selective PKC_epsilon Inhibitors to Treat Alcoholism
    JAY JIE QIANG WU; Fiscal Year: 2013
    ..of a novel oral compound that acts as isoform specific inhibitor of the enzyme protein kinase C epsilon (PKCe), which has been demonstrated an ideal target for alcohol use disorders...
  7. R John Solaro; Fiscal Year: 2016
    ..via AMPK/Paki (with emphasis on the evolution and rescue of familial hypertrophic cardiomyopathy (FHC);and via PKCe, and with emphasis on dilated cardiomyopathy, novel phosphorylation sites and on rescue...
  8. HERB-INDUCED OXIDANT PRECONDITIONING IN CARDIOMYOCYTES
    Zuo Hui Shao; Fiscal Year: 2010
    ..protection against murine cardiomyocyte I/R injury via a transient ROS generation that initiates the activation of PKCe and/or Akt resulting in eNOS activation and increased reperfusion NO generation...
  9. PKC-e Mechanisms in Acute and Chronic Pain
    JON DAVID LEVINE; Fiscal Year: 2011
    ..Messing (Project #2) have revealed that the epsilon isoform of protein kinase C (PKCe) plays a central role in hyperalgesia induced by some inflammatory mediators, and we have identified a novel PKCe- ..
  10. Control of Ethanol Intake by an mGluR5-PKCe Pathway
    M Foster Olive; Fiscal Year: 2013
    ..abstract_text> ..
  11. Marcelo G Kazanietz; Fiscal Year: 2015
    ..in human prostate cancer (as well as in several other epithelial cancers) is the marked overexpression of PKCe, a survival and mitogenic Ser-Thr kinase that is a receptor for the phorbol ester tumor promoters...
  12. Ethanol Regulation of GABAalpha receptors
    Sandeep Kumar; Fiscal Year: 2009
    ..Specific Aim 2 will utilize these mice to determine if PKCy and PKCe differentially alter the effects of ethanol on membrane expression and internalization of specific GABAA receptors...
  13. OXYGEN RADICALS AND CARDIAC ADAPTATIONS TO ISCHEMIA
    Roberto Bolli; Fiscal Year: 2009
    ..lypothesis is that exercise-induced release of NO (via eNOS) activates a signal transduction cascade that includes PKCe, Src/Lck, and multiple transcription factors and culminates in the upregulation of iNOS, which then mediates the ..
  14. The role of PKC epsilon in alcoholic liver disease
    JONATHAN PHILLIP KAISER; Fiscal Year: 2010
    ..Protein kinase c-epsilon (PKCe) has been shown to cause hepatic insulin resistance as well non-alcoholic fatty liver disease, therefore we ..
  15. ROLE OF P90RSK IN DIABETIC CARDIOMYOPATHY
    Jun Ichi Abe; Fiscal Year: 2003
    ..2) Phosphorylation of TnI is increased in PKCB2, but not in PKCe transgenic mice. 3) p90RSK activity is increased in myocardial samples from patients with end-stage heart failure...
  16. Cardiomyocyte Signaling Through Focal Adhesion
    MARIA HEIDKAMP; Fiscal Year: 2003
    ..Therefore, experiments will be performed to determine the effects of overexpression of mutant forms of PKCe on FAF and SA in cultured neonatal rat myocytes...
  17. How does blood flow regulate endothelial function?
    Hanjoong Jo; Fiscal Year: 2003
    ..in cultured bovine aortic endothelial cells (BAEC) in a shear force-dependent manner by mechanisms involving Gi2a, PKCe, Src, FAK, and Ras...
  18. Mitochondrial PKC epsilon in cardiac protection
    Jun Zhang; Fiscal Year: 2006
    ..protect against myocardial ischemia/reperfusion injury via signaling mechanisms that involve protein kinase C e (PKCe). The downstream effectors targeted by PKCe to carry out protection remain poorly defined...
  19. MECHANISM OF LEAD INDUCED NEUROTOXICITY
    DAVID TERRIAN; Fiscal Year: 2001
    ..3) that actin is a PKCepsilon anchoring protein, 4) that actin is also a PKCepsilon, chaperon that secures PKCE in a catalytically active conformation, and 5) that Pb2+ and PKC interactions prime SVs for transport by augmenting ..
  20. Regulation of power output in cardiac myocytes
    KERRY MC DONALD; Fiscal Year: 2007
    ..A final aim is determine the effects of PKCe-induced phosphorylation on myofibrillar power output...
  21. CELL SIGNAL TRANSDUCTION IN CORNEAL WOUND HEALING
    Haydee Bazan; Fiscal Year: 2006
    ..We will investigate the role of three specific protein kinase C (PKC) isoforms, PKCa, PKCe, and PKCu, as modulators of cell proliferation and migration and the relation between two MAPK cascades, ERK1/2 and ..
  22. Prenatal Cocaine Exposure and Cardiac Programming
    Lubo Zhang; Fiscal Year: 2009
    ..Among other mechanisms, numerous studies have demonstrated that PKCe plays a pivotal role of cardioprotection during cardiac ischemia and reperfusion injury...
  23. PKC signalling and cell-cell communication
    THOMAS HUND; Fiscal Year: 2006
    ..PKC-epsilon null (PKCe-KO) mice, isoform-specific PKC activator and inhibitor peptides, adenoviruses expressing PKC isoforms, and phospho-..
  24. Mechanism of Preconditioning and Cardiocyte Apoptosis
    Zhenhai Yao; Fiscal Year: 2001
    ..We hypothesize that during preconditioning oxygen radicals open mitochodrial KATP channels through PKCe activation is the primary signal transduction pathway that blocks apoptosis in IR...
  25. Specificity of calcium channels in neuronal signaling
    Ji fang Zhang; Fiscal Year: 2010
    ..We will address: (1) Physiological factors, such as phosphorylation by protein kinases, regulate formation of the PKCe-ENH-N-type Ca2+ channel complex...
  26. Pramipexole in Treatment-Resistant Depression
    Roy Perlis; Fiscal Year: 2007
    ..The proposed investigation and training program will provide critical skills, experience and data to aid the candidate in writing an R01 and becoming an independent investigator. ..
  27. MicroRNA-mediated Gene Regulation in Lung Development
    JINING LU; Fiscal Year: 2010
    ..Little is known how these molecules function in the embryonic lung and what genes they regulate. This study will provide insights into this issue and will help to understand mechanism of human diseases. ..
  28. Signal Transduction in Depression
    Richard Shelton; Fiscal Year: 2008
    ..These studies may shed light on important cellular mediators of depression and provide new targets for amelioration. [unreadable] [unreadable]..
  29. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY YW BOURGUIGNON; Fiscal Year: 2010
    ....
  30. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2009
    ..The long-term objective is to develop strategies to intervene with these pathways to inhibit progression of breast cancer. ..
  31. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..The greatest potential for arresting this epidemic is likely to come through a clearer understanding of its molecular pathogenesis to develop rational and mechanism based therapy. ..
  32. Vanilloid Receptors in Diabetic Peripheral Neuropathy
    LOUIS PREMKUMAR; Fiscal Year: 2006
    ....
  33. Mechanisms of p42/44MAPK-induced LDL receptor expression
    KAMAL MEHTA; Fiscal Year: 2004
    ..This knowledge could be exploited to develop improved hypercholesterolemia therapies and to reduce foam cell formation. ..
  34. Endogenous Activators of Vanilloid Receptor
    LOUIS PREMKUMAR; Fiscal Year: 2004
    ..Protein kinase C (PKC) plays an important role in pain signaling. Targeted deletion of PKC epsilon in mice dramatically attenuates thermal- and acid-induced hyperalgesia...
  35. SIGNAL TRANSDUCTION AND CELL DEATH REGULATION
    Alakananda Basu; Fiscal Year: 2004
    ....
  36. Identification of Alcohol Binding Site(s) in Protein Kinase C Epsilon
    Joydip Das; Fiscal Year: 2007
    ..of this proposal is to identify alcohol binding sites on a signal transducing protein, protein kinase C epsilon (PKCe), and to determine the secondary structure of these sites...
  37. MOLECULAR NEUROBIOLOGY OF DEPRESSION
    Richard Shelton; Fiscal Year: 2003
    ..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..
  38. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2007
    ..abstract_text> ..
  39. Role of Vanilloid Receptors in Diabetic Peripheral Neuropathy
    LOUIS PREMKUMAR; Fiscal Year: 2008
    ..The complications of DPN can be prevented/delayed by maintaining normal glucose levels and expression and function of TRP channels by therapeutic interventions. ..