PKC delta

Summary

Gene Symbol: PKC delta
Description: protein kinase C delta
Alias: ALPS3, CVID9, MAY1, PKCD, nPKC-delta, protein kinase C delta type, protein kinase C delta VIII, tyrosine-protein kinase PRKCD
Species: human

Top Publications

  1. ncbi Regulation of cell apoptosis by protein kinase c delta
    C Brodie
    Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Apoptosis 8:19-27. 2003
  2. ncbi Phosphorylation of HIV-1 gag proteins by protein kinase C
    B Burnette
    Laboratory of Biological Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:8698-703. 1993
  3. pmc Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis
    T Ghayur
    BASF Bioresearch Corporation, Worcester, Massachusetts 01605, USA
    J Exp Med 184:2399-404. 1996
  4. pmc Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons
    Y Matsuoka
    Howard Hughes Medical Institute and Departments of Cell Biology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cell Biol 142:485-97. 1998
  5. ncbi Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
    J A Le Good
    Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Science 281:2042-5. 1998
  6. pmc Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis
    A Bharti
    Cancer Pharmacology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 18:6719-28. 1998
  7. pmc A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor
    Y Izumi
    Department of Molecular Biology, Yokohama City University School of Medicine 3 9, Fuku ura, Kanagawa ku, Yokohama 236 0004, Japan
    EMBO J 17:7260-72. 1998
  8. ncbi Regulated interaction of protein kinase Cdelta with the heterogeneous nuclear ribonucleoprotein K protein
    D S Schullery
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 274:15101-9. 1999
  9. pmc Phosphorylation sites of protein kinase C delta in H2O2-treated cells and its activation by tyrosine kinase in vitro
    H Konishi
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Proc Natl Acad Sci U S A 98:6587-92. 2001
  10. ncbi Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727
    Shahab Uddin
    Section of Hematology Oncology, Department of Medicine, University of Illinois at Chicago and West Side Veterans Administration Medical Center, Chicago, Illinois 60607, USA
    J Biol Chem 277:14408-16. 2002

Research Grants

  1. Manuela Bartoli; Fiscal Year: 2016
  2. Satya P Kunapuli; Fiscal Year: 2016
  3. ANUMANTHA GOUNDER KANTHASAMY; Fiscal Year: 2015
  4. Bo Liu; Fiscal Year: 2014
  5. Neuroinflammatory Mechanisms in the Progression of Parkinson's Disease
    Arthi Kanthasamy; Fiscal Year: 2012
  6. Stephen M Black; Fiscal Year: 2016
  7. Marcelo G Kazanietz; Fiscal Year: 2015
  8. Douglas V Faller; Fiscal Year: 2014
  9. ANUMANTHA GOUNDER KANTHASAMY; Fiscal Year: 2015
  10. ECM MATRIX, PROTEASE AND MELANOMA PROLIFERATION
    Yves DeClerck; Fiscal Year: 2007

Detail Information

Publications161 found, 100 shown here

  1. ncbi Regulation of cell apoptosis by protein kinase c delta
    C Brodie
    Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Apoptosis 8:19-27. 2003
    ..Recent findings on these aspects of the PKCdelta cascades are the major focus of this review...
  2. ncbi Phosphorylation of HIV-1 gag proteins by protein kinase C
    B Burnette
    Laboratory of Biological Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:8698-703. 1993
    ..These data are consistent with the identification of a highly conserved consensus PKC phosphorylation site motif in the HIV-1 gag protein at Ser111 and suggests that PKC phosphorylation plays an important role in gag protein function...
  3. pmc Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis
    T Ghayur
    BASF Bioresearch Corporation, Worcester, Massachusetts 01605, USA
    J Exp Med 184:2399-404. 1996
    ..However, the relationship of PKC delta cleavage to induction of apoptosis is unknown...
  4. pmc Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons
    Y Matsuoka
    Howard Hughes Medical Institute and Departments of Cell Biology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cell Biol 142:485-97. 1998
    ....
  5. ncbi Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
    J A Le Good
    Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Science 281:2042-5. 1998
    ..The activation loop phosphorylation of PKCdelta in response to serum stimulation of cells was PI 3-kinase-dependent and was enhanced by PDK1 coexpression...
  6. pmc Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis
    A Bharti
    Cancer Pharmacology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 18:6719-28. 1998
    ..These findings support the hypothesis that functional interactions between PKCdelta and DNA-PK contribute to DNA damage-induced apoptosis...
  7. pmc A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor
    Y Izumi
    Department of Molecular Biology, Yokohama City University School of Medicine 3 9, Fuku ura, Kanagawa ku, Yokohama 236 0004, Japan
    EMBO J 17:7260-72. 1998
    ..These results suggest that MDC9 and PKCdelta are involved in the stimulus-coupled shedding of the proHB-EGF ectodomain...
  8. ncbi Regulated interaction of protein kinase Cdelta with the heterogeneous nuclear ribonucleoprotein K protein
    D S Schullery
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 274:15101-9. 1999
    ..The regulated nature of the PKCdelta-K protein interaction may serve to meet cellular needs at sites of active transcription, RNA processing and translation in response to changing extracellular environment...
  9. pmc Phosphorylation sites of protein kinase C delta in H2O2-treated cells and its activation by tyrosine kinase in vitro
    H Konishi
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Proc Natl Acad Sci U S A 98:6587-92. 2001
    Protein kinase C delta (PKC delta) is normally activated by diacylglycerol produced from receptor-mediated hydrolysis of inositol phospholipids...
  10. ncbi Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727
    Shahab Uddin
    Section of Hematology Oncology, Department of Medicine, University of Illinois at Chicago and West Side Veterans Administration Medical Center, Chicago, Illinois 60607, USA
    J Biol Chem 277:14408-16. 2002
    ..Altogether, these findings indicate that PKC-delta functions as a serine kinase for Stat1 and an upstream regulator of the p38 MAP kinase and plays an important role in the induction of Type I IFN-biological responses...
  11. ncbi Calcium-dependent involucrin expression is inversely regulated by protein kinase C (PKC)alpha and PKCdelta
    Anne Deucher
    Department of Physiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Biol Chem 277:17032-40. 2002
    ..These findings suggest that PKCalpha and PKCdelta are required for, and modulate, calcium-dependent keratinocyte differentiation in opposing directions...
  12. pmc Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells
    Makoto Sumitomo
    Department of Urology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Clin Invest 109:827-36. 2002
    ..These results indicate that PKCdelta plays a crucial role in activating anticancer drug-induced apoptosis signaling by amplifying the Cer-mediated mitochondrial amplification loop...
  13. ncbi HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta
    Yamina Bennasser
    Laboratoire d Immuno Virologie, EA 3038, Universite Paul Sabatier, 31062 Toulouse, France
    FASEB J 16:546-54. 2002
    ..Altogether, these results suggest that the induction of IL-10 by Tat is strictly dependent on the PKC-delta and -betaII isoforms...
  14. ncbi p73beta is regulated by protein kinase Cdelta catalytic fragment generated in the apoptotic response to DNA damage
    Jian Ren
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 277:33758-65. 2002
    ..These findings demonstrate that cleavage of PKCdelta to PKCdeltaCF induces apoptosis by a mechanism in part dependent on PKCdeltaCF-mediated phosphorylation of the p73beta Ser-289 site...
  15. ncbi Activation of SAPK/JNK signaling by protein kinase Cdelta in response to DNA damage
    Kiyotsugu Yoshida
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:48372-8. 2002
    ..These findings indicate that PKCdelta functions in the activation of SAPK through a Lyn --> PKCdelta --> MEKK1 --> MKK7 --> SAPK signaling cascade in response to DNA damage...
  16. pmc Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9
    Kiyotsugu Yoshida
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 22:1431-41. 2003
    ..These findings demonstrate that PKCdelta is responsible for the regulation of Rad9 in the Hus1-Rad1 complex and in the apoptotic response to DNA damage...
  17. ncbi Phospholipid scramblase 3 is the mitochondrial target of protein kinase C delta-induced apoptosis
    Jihua Liu
    Huntsman Cancer Institute and Section of Oncology, Department of Medicine, University of Utah, Salt Lake City, Utah 84112, USA
    Cancer Res 63:1153-6. 2003
    ..These results indicate that PLS3 is a downstream effector of PKC-delta in the mitochondria...
  18. ncbi Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells
    Katrin Eitel
    Internal Medicine IV, University of Tubingen, Tubingen, Germany
    Diabetes 52:991-7. 2003
    ..These data suggest that nuclear translocation and kinase activity of PKC-delta are both necessary for saturated fatty acid-induced apoptosis...
  19. ncbi Physical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human platelets
    David Crosby
    Department of Pharmacology, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 278:24533-41. 2003
    ....
  20. ncbi Activation of protein kinase C delta by all-trans-retinoic acid
    Suman Kambhampati
    Robert H Lurie Comprehensive Cancer Center and the Division of Hematology Oncology, Northwestern University Feinberg School of Medicine and Lakeside Veterans Affairs Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 278:32544-51. 2003
    ..In this report, we provide evidence that a member of the protein kinase C (PKC) family of proteins, PKC delta, is activated during RA treatment of the NB-4 and HL-60 acute myeloid leukemia cell lines as well as the MCF-7 ..
  21. ncbi Differential role of protein kinase C delta isoform in agonist-induced dense granule secretion in human platelets
    Swaminathan Murugappan
    Departments of Physiology and Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 279:2360-7. 2004
    ..Furthermore, PKCdelta plays a positive role in protease-activated receptor-mediated dense granule secretion, whereas it functions as a negative regulator downstream of glycoprotein VI signaling...
  22. pmc Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling
    Peter Storz
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 24:2614-26. 2004
    ..Once active, the signal is relayed to the activation of NF-kappaB in oxidative stress responses...
  23. ncbi Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation
    Ke Wen Zhao
    Health Science Center, Shanghai Second Medical University, Shanghai Institutes for Biological Sciences and Graduate School of the Chinese Academy of Sciences, China
    Blood 104:3731-8. 2004
    ..Taken together, these results suggest that as a protein induced upon PKCdelta activation, PLSCR1 is required for ATRA- and PMA-triggered leukemic cell differentiation...
  24. ncbi Protein kinase Cdelta regulates apoptosis via activation of STAT1
    Tracie A DeVries
    Department of Craniofacial Biology, School of Dentistry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:45603-12. 2004
    ..Our data identify STAT1 as a downstream target of PKCdelta and suggest that PKCdelta may regulate apoptosis by activation of STAT1 target genes...
  25. pmc Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex
    Tatiana Efimova
    Department of Physiology, Case Western Reserve University School of Medicine, 2109 Adelbert Rd, Cleveland, OH 44106 4970, USA
    Mol Cell Biol 24:8167-83. 2004
    ..This regulation appears to be physiological, since H(2)O(2), a known inducer of keratinocyte apoptosis, promotes identical PKCdelta and p38delta-ERK1/2 activity changes, leading to similar morphological changes...
  26. ncbi Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes
    Erik A Bey
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 173:5730-8. 2004
    ..Together, these data suggest that PKCdelta plays a pivotal role in stimulating monocyte NADPH oxidase activity through its regulation of the phosphorylation and translocation of p47phox...
  27. ncbi Protein kinase Cdelta regulates p67phox phosphorylation in human monocytes
    Xiaoxian Zhao
    Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Leukoc Biol 77:414-20. 2005
    ..Taken together, this is the first report to describe the requirement of PKCdelta in regulating the phosphorylation of p67phox and the related NADPH oxidase activity in primary human monocytes...
  28. ncbi Regulation of monocyte apoptosis by the protein kinase Cdelta-dependent phosphorylation of caspase-3
    Oliver H Voss
    Heart and Lung Research Institute and Division of Pulmonary and Critical Care, Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 280:17371-9. 2005
    ..Our results provided evidence that the PKCdelta-dependent phosphorylation of caspase-3 provided a novel pro-apoptotic mechanism involved in the regulation of monocyte life span...
  29. ncbi Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells
    Sanaa M Nabha
    Department of Pathology, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    Oncogene 24:3166-76. 2005
    ..05). Taken together, these data suggest that PKC-delta plays a major role in antiestrogen resistance in breast tumor cells and thus provides a new target for treatment...
  30. ncbi Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cdelta-dependent induction of p21
    Motonori Nakagawa
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Biol Chem 280:33926-34. 2005
    ..Our results identify a novel link between PKCdelta and G1 arrest via p21 up-regulation and highlight the complexities in the downstream effectors of PKC isozymes in the context of cell cycle progression and proliferation...
  31. pmc The signaling network of transforming growth factor beta1, protein kinase Cdelta, and integrin underlies the spreading and invasiveness of gastric carcinoma cells
    Mi Sook Lee
    Cancer Research Institute, College of Medicine, Seoul National University, Republic of Korea
    Mol Cell Biol 25:6921-36. 2005
    ....
  32. ncbi PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration
    Jianhua Fan
    The Department of Dermatology and the Norris Comprehensive Cancer Center, The University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Invest Dermatol 126:1233-43. 2006
    ..Instead, inhibition of PKCdelta blocks PDGF-BB-stimulated activation of signal transducer and activator of transcription 3 (Stat3). This study unveiled the specificity of PKCdelta in the control of DF migration...
  33. ncbi Activation of protein kinase C delta induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase
    Kenta Koike
    Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan
    Thyroid 16:333-41. 2006
    ..PKCdelta may therefore be an effective molecular target for novel therapy in thyroid cancer...
  34. pmc The protein kinase C delta catalytic fragment targets Mcl-1 for degradation to trigger apoptosis
    Leonid A Sitailo
    Department of Pathology and the Oncology Institute, Skin Cancer Research Program, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Biol Chem 281:29703-10. 2006
    ..Overall our results identify Mcl-1 as an important target for PKCdelta-cat that can mediate its pro-apoptotic effects on mitochondria to amplify the apoptotic signaling induced by a wide range of apoptotic stimuli...
  35. ncbi PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation
    Giordano Pula
    Department of Pharmacology, School of Medical Sciences, University of Bristol, United Kingdom
    Blood 108:4035-44. 2006
    ..PKCdelta is therefore a critical negative regulator of filopodia, and hence platelet aggregation, through a functional interaction with the actin organizer VASP...
  36. ncbi Regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 by protein kinase Cdelta-mediated phosphorylation
    You Take Oh
    Division of Pharmaceutical Biosciences, College of Pharmacy, Seoul National University, Seoul, 151 742, Republic of Korea
    Apoptosis 12:1339-47. 2007
    ..Thus, post-translational phosphorylation of p21(WAF1/CIP1) is important from an apoptotic cell death, and may also have patho-physiological relevance for the development of human cancer...
  37. ncbi Induction of apoptosis is driven by nuclear retention of protein kinase C delta
    Tracie A DeVries-Seimon
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Biol Chem 282:22307-14. 2007
    Protein kinase C delta (PKC delta) mediates apoptosis downstream of many apoptotic stimuli. Because of its ubiquitous expression, tight regulation of the proapoptotic function of PKC delta is critical for cell survival...
  38. ncbi Protein kinase C-delta regulates the stability of hypoxia-inducible factor-1 alpha under hypoxia
    Ji Won Lee
    Neurovascular Coordination Research Center and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Cancer Sci 98:1476-81. 2007
    ..These effects were completely reversed by PKC-delta overexpression following the knockdown of PKC-delta. Collectively, these findings demonstrate the role of PKC-delta as a new regulator of hypoxia-induced angiogenesis...
  39. ncbi Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting
    Dietlinde Wolf
    University of Miami, Miller School of Medicine, Department of Microbiology and Immunology, BCRI 739, Miami, FL 33136, USA
    Virology 370:45-54. 2008
    ..We conclude that the activation of nPKCs by Nef is required to increase viral replication/infectivity and direct the subcellular localization of Nef...
  40. pmc Multiple PKCdelta tyrosine residues are required for PKCdelta-dependent activation of involucrin expression--a key role of PKCdelta-Y311
    Ling Zhu
    Department of Physiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Invest Dermatol 128:833-45. 2008
    ..These findings indicate that PKCdelta activity requires Y(311) and a second tyrosine residue; however, any one of the several tyrosine residues can serve in the secondary role...
  41. ncbi PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism
    Joaquin Villar
    Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057 1482, USA
    Cancer Res 67:10859-68. 2007
    ..PCPH regulated invasiveness and collagen I expression by a mechanism involving protein kinase C delta (PKC delta): (a) PCPH knockdown in LNCaP cells decreased PKC delta levels relative to control cells; (b) PKC delta ..
  42. pmc PKCdelta survival signaling in cells containing an activated p21Ras protein requires PDK1
    Shuhua Xia
    Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Cell Signal 21:502-8. 2009
    ....
  43. doi Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction
    Feng Hou Gao
    NO 3 People s Hospital affiliated to Shanghai Jiao Tong University School of Medicine SJTU SM, Shanghai, China
    Exp Cell Res 315:3250-8. 2009
    ..To our knowledge, this is the first demonstration that proteolytically activated PKC-delta down-regulates hnRNP K protein in a proteasome-dependent manner, which plays an important role in apoptosis induction...
  44. doi PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer
    Laura V Mauro
    Research Area, Institute of Oncology Angel H Roffo, University of Buenos Aires, Buenos Aires, Argentina
    Pancreas 39:e31-41. 2010
    ..Our objective was to study the role of protein kinase C delta (PKCdelta) in the progression of human pancreatic carcinoma...
  45. doi PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation
    Mariapaola Nitti
    Department of Experimental Medicine, University of Genoa, Italy
    Cell Signal 22:828-35. 2010
    ..gain in neuronal morphological features and these events are accompanied by the increased expression level of PKC delta and p67(phox), one of the components of NADPH oxidase...
  46. pmc Protein kinase C δ is a downstream effector of oncogenic K-ras in lung tumors
    Jennifer M Symonds
    Program in Cancer Biology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Cancer Res 71:2087-97. 2011
    ....
  47. ncbi Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C
    Y Matsuoka
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 271:25157-66. 1996
    ..These findings suggest a complex reciprocal relationship between regulation of adducin function by calmodulin binding and phosphorylation by PKA and PKC...
  48. pmc Protein kinase C-delta C2-like domain is a binding site for actin and enables actin redistribution in neutrophils
    G Lopez-Lluch
    Centre for Molecular Medicine, Department of Medicine, University College London, The Rayne Institute, 5 University Street, London WC1E 6JJ, UK
    Biochem J 357:39-47. 2001
    ..Microinjection of deltaC2 also inhibits F-actin redistribution. Thus PKC-delta binds to F-actin through its C2 domain, and these interactions are important in regulating actin redistribution in neutrophils...
  49. pmc Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway
    Xianjun Fang
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 22:2099-110. 2002
    ..LPA and potentially other natural ligands primarily utilize a PKC-dependent pathway to modulate GSK-3...
  50. ncbi Independence of protein kinase C-delta activity from activation loop phosphorylation: structural basis and altered functions in cells
    Yin Liu
    Experimental Immunology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:12102-11. 2006
    ..Thus, activation loop phosphorylation of PKC-delta may regulate its function in cells in a novel way...
  51. pmc The von Hippel-Lindau tumour-suppressor protein interaction with protein kinase Cdelta
    Xavier Iturrioz
    Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Biochem J 397:109-20. 2006
    ..Thus, in contrast with aPKC, PKCdelta is not a conventional substrate of the ubiquitin-ligase complex, VCB-Cul-2, and the observed interaction between these two proteins must underlie a distinct signalling output...
  52. pmc Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin
    Yutong Zhao
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cell Signal 19:2329-38. 2007
    ..Pretreatment with LPA reversed HGF-induced c-Met internalization. Overexpression of dominant negative (Dn)-PKC delta or pretreatment with Rottlerin or Pertussis toxin (PTx) attenuated LPA-induced c-Met serine phosphorylation and ..
  53. pmc Protein kinase C delta mediates arterial injury responses through regulation of vascular smooth muscle cell apoptosis
    Dai Yamanouchi
    Division of Peripheral Vascular Surgery, Department of Surgery, University of Wisconsin Madison, 1111 Highland Avenue, WIMR 5120, Madison, WI 53705, USA
    Cardiovasc Res 85:434-43. 2010
    ..Here we investigate the role of PKCdelta in intimal hyperplasia through gene deletion or overexpression in rodent models of arterial injury...
  54. ncbi Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta
    Kristen Page
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
    J Immunol 170:5681-9. 2003
    ..We investigated the regulation of these NF-kappa B-dependent genes by the novel protein kinase C (PKC) isoform PKC delta in 16HBE14o- human airway epithelial cells, focusing on IL-8 expression...
  55. ncbi A role for zeta protein kinase C in nerve growth factor-induced differentiation of PC12 cells
    M W Wooten
    Department of Zoology, Auburn University, Alabama 36849
    Cell Growth Differ 5:395-403. 1994
    ..In addition, the zeta-pseudosubstrate peptide inhibited NGF-induced activation of PKC-zeta.(ABSTRACT TRUNCATED AT 250 WORDS)..
  56. doi Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta
    G Frangioudakis
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales, 2010, Australia
    Diabetologia 52:2616-20. 2009
    ....
  57. doi Genome-wide analysis of DHEA- and DHT-induced gene expression in mouse hypothalamus and hippocampus
    Qianxing Mo
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    J Steroid Biochem Mol Biol 114:135-43. 2009
    ..More broadly, the results may be clinically significant because they provide new insights into processes that appear to mediate the diverse CNS effects attributed to DHEA...
  58. ncbi Regulation of expression and activity of four PKC isozymes in confluent and mechanically stimulated UMR-108 osteoblastic cells
    W D Geng
    Department of Physiology, Marshall University School of Medicine, Huntington, West Virginia 25704, USA
    J Cell Physiol 189:216-28. 2001
    ..1994. J Bone Miner Res 9(7):999-1011) that PKC could be involved in the early phase of mechanotransduction in osteoblasts through the activation of focal adhesion assembly/disassembly and the remodeling of the actin cytoskeleton...
  59. pmc Identification of novel androgen receptor target genes in prostate cancer
    Unnati Jariwala
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Mol Cancer 6:39. 2007
    ..The androgen receptor (AR) plays critical roles in both androgen-dependent and castrate-resistant prostate cancer (PCa). However, little is known about AR target genes that mediate the receptor's roles in disease progression...
  60. pmc Detailed protein sequence alignment based on Spectral Similarity Score (SSS)
    Kshitiz Gupta
    Department of Computer Science and Engineering, Indian Institute of Technology, Bombay, Mumbai, India
    BMC Bioinformatics 6:105. 2005
    ..This approach finds a similarity score between sequences based on any given attribute, like hydrophobicity of amino acids, on the basis of spectral information after partial conversion to the frequency domain...
  61. pmc Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction
    Gary J Litherland
    Cell Signalling, Injury and Repair Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 285:22414-25. 2010
    ..Small interfering RNA-mediated silencing of PKC gene expression showed that both novel (nPKC delta, nPKC eta) and atypical (aPKC zeta, aPKC iota) isoforms were involved in collagenase induction by IL-1...
  62. doi Selective activation of protein kinase C-delta and -epsilon by 6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U)
    I Coutinho
    Laboratorio de Microbiologia, REQUIMTE CEQUP, Faculdade de Farmacia, Universidade do Porto, Rua Anibal Cunha, 164, 4050 047 Porto, Portugal
    Biochem Pharmacol 78:449-59. 2009
    ....
  63. doi Genetic variants in melatonin synthesis and signaling pathway are not associated with adolescent idiopathic scoliosis
    Lesa M Nelson
    Axial Biotech, Inc, Salt Lake City, Utah, USA
    Spine (Phila Pa 1976) 36:37-40. 2011
    ..Genetic association study investigating the association of genetic markers of melatonin signaling and biosynthesis with adolescent idiopathic scoliosis (AIS)...
  64. ncbi Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta
    K Mizuno
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Eur J Biochem 202:931-40. 1991
    cDNA clones coding for novel protein kinase C delta (nPKC delta) were isolated from a mouse brain cDNA library. Mouse nPKC delta consists of 674 amino acid residues and has sequence identity of 95% with rat nPKC delta...
  65. ncbi Differential localisation of nPKC delta during cell cycle progression
    Carla Perego
    CNR, Institute of Neuroscience, Section of Cellular and Molecular Pharmacology and Department of Medical Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milano, Italy
    Biochem Biophys Res Commun 294:127-31. 2002
    b>nPKC delta is a phospholipid-dependent and calcium-independent PKC isoform, whose over expression in BL6T murine melanoma cells, modifies their proliferative and metastatic potential in vivo...
  66. pmc Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr311 and Tyr565 and phospholipase C signalling
    Kellie J Hall
    Department of Pharmacology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, U K
    Biochem J 406:501-9. 2007
    ..to thrombin, and have examined the interplay between phosphorylation and the classical lipid-mediated activation of PKCd. Phosphorylation of both Tyr311 and Tyr565 is dependent on Src kinase and PLC (phospholipase C) activity in ..
  67. ncbi Localization and developmental expression of a novel protein kinase C delta gene
    H M Kim
    Department of Pathology, Osaka University Medical School, Japan
    Brain Res Dev Brain Res 70:239-44. 1992
    The expression and localization of a novel protein kinase C delta (nPKC delta) mRNA were investigated using Northern blotting and in situ hybridization in the developmental process of mouse brain...
  68. pmc A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle
    S Osada
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Mol Cell Biol 12:3930-8. 1992
    ..a protein, nPKC theta, which consists of 707 amino acid residues and showed the highest sequence similarity to nPKC delta (67.0% in total)...
  69. ncbi The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C
    T Herget
    Institute of Physiological Chemistry, University of Mainz, Germany
    Eur J Biochem 233:448-57. 1995
    ..The apparent affinity of nPKC delta (Km = 0.06 microM) was higher than that of nPKC epsilon and cPKC beta 1 (Km = 0.32 microM)...
  70. ncbi Induction of thymocyte apoptosis by Ca2+-independent protein kinase C (nPKC) activation and its regulation by calcineurin activation
    A Asada
    Integrative Projects, Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194, Japan
    J Biol Chem 273:28392-8. 1998
    ..These results indicate that activation of nPKC, especially nPKC-theta, induces apoptosis in thymocytes and that calcineurin activation regulates the apoptosis...
  71. ncbi Possible involvement of PKC isoforms in signalling placental apoptosis in intrauterine growth retardation
    M C Sugden
    Department of Diabetes and Metabolic Medicine, Division of General and Developmental Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London E1 4NS, UK
    Mol Cell Endocrinol 185:119-26. 2001
    ....
  72. ncbi Dose-dependent differential expression of protein kinase C isozymes in mouse lymphocytes after gamma irradiation in vivo and ex vivo
    Prajakta A Varadkar
    Radiation Biology Division, Bhabha Atomic Research Centre, Mumbai 4000 85, India
    Radiat Res 159:453-7. 2003
    ..Moreover, the differences between the response of a single cell and that of the whole animal must be considered...
  73. pmc Estradiol increases angiotensin II type 1 receptor in hearts of ovariectomized rats
    Vincent Ricchiuti
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Endocrinol 200:75-84. 2009
    ..In summary, E(2) treatment increased cardiac expression of AT(1)R as well as the expression of pro-inflammatory and prothrombotic factors...
  74. doi Targeting PKC delta-mediated topoisomerase II beta overexpression subverts the differentiation block in a retinoic acid-resistant APL cell line
    S McNamara
    Division of Experimental Medicine, Department of Oncology, Segal Cancer Comprehensive Centre, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Leukemia 24:729-39. 2010
    ..Cumulatively, our data suggest a model whereby inhibition of PRKCD decreases TOP2B protein levels, leading to a loss of TOP2B-mediated repressive effects on RA-induced transcription and granulocytic differentiation...
  75. pmc Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions
    Fernando Benavides
    Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, USA
    Cell Cycle 10:268-77. 2011
    ..Our results argue for a causal link between PKCε overexpression and prostate cancer development...
  76. ncbi Characterization of the protein kinase C signal transduction pathway in cisplatin-sensitive and -resistant human small cell lung carcinoma cells
    A Basu
    Department of Pharmacology, University of Pittsburgh, Pennsylvania 15261, USA
    Cell Growth Differ 7:1507-12. 1996
    ..A decrease in cPKC alpha and-beta and an increase in nPKC delta were associated with the cDDP-resistant phenotype. The abundance of aPKC zeta or-iota was unaffected...
  77. ncbi Estrogen deficiency decreases ischemic tolerance in the aged rat heart: Roles of PKCdelta, PKCepsilon, Akt, and GSK3beta
    J C Hunter
    Intercollege Program in Physiology, The Pennsylvania State University, University Park, PA 16802, USA
    Am J Physiol Regul Integr Comp Physiol 292:R800-9. 2007
    ....
  78. pmc A mouse model of pulmonary metastasis from spontaneous osteosarcoma monitored in vivo by Luciferase imaging
    Silvia Miretti
    Department of Morphophysiology, School of Veterinary Medicine, University of Torino, Grugliasco, Turin, Italy
    PLoS ONE 3:e1828. 2008
    ..We report the development of a syngeneic (Balb/c) murine OSA model, using a cell line derived from a spontaneous murine tumor...
  79. doi Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells
    E Wallerstedt
    The Lundberg Laboratory for Diabetes Research, Center of Excellence for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine Diabetes, the Sahlgrenska Academy at University of Gothenburg, Bla Straket 5, SE 413 45, Gothenburg, Sweden
    Diabetologia 53:946-54. 2010
    ..The aim of the study was to address the role of protein kinase C-delta (PKCdelta) on phosphorylation of signal transducer and activator of transcription 3 (STAT3) and activation of inflammatory genes in response to IL-6 in adipose cells...
  80. ncbi Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 144:3928-35. 1990
    ....
  81. ncbi Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta
    C H Reynolds
    Department of Neuroscience, Institute of Psychiatry, King s College London, England
    J Neurochem 74:1587-95. 2000
    ..Thus, the three MAP kinases and GSK3beta are importantly all strong candidates as tau kinases that may be involved in the pathogenic hyperphosphorylation of tau in Alzheimer's disease...
  82. ncbi Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function
    Viktoria Kheifets
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 281:23218-26. 2006
    ..We show that following cell activation, deltaPKC-annexin V binding is a transient and an essential step in the function of deltaPKC, thus identifying a new role for annexin V in PKC signaling and a new step in PKC activation...
  83. ncbi Insulin generates free radicals in human fibroblasts ex vivo by a protein kinase C-dependent mechanism, which is inhibited by pravastatin
    Giulio Ceolotto
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Via Giustiniani 2, 35128 Padova, Italy
    Free Radic Biol Med 41:473-83. 2006
    ..subunit of NAD(P)H oxidase from the cytosol to the membrane and generation of radical oxygen species through a PKC delta-dependent mechanism...
  84. ncbi Protein kinase C-beta and -delta isoenzymes promote arachidonic acid production and proliferation of MonoMac-6 cells
    Zoltán Griger
    Department of Physiology, University of Debrecen, Research Center for Molecular Medicine, Medical and Health Science Center, Nagyerdei krt 98, 4032, Debrecen, Hungary
    J Mol Med (Berl) 85:1031-42. 2007
    ....
  85. doi Phorbol ester-stimulated NF-kappaB-dependent transcription: roles for isoforms of novel protein kinase C
    Neil S Holden
    Airways Inflammation Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Cell Signal 20:1338-48. 2008
    ....
  86. pmc Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells
    Cleide Gonçalves da Silva
    Center for Vascular Biology Research and the Division of Vascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Circulation 119:871-9. 2009
    ..Extracellular nucleotides activate eNOS and increase NO generation; however, the mechanism of this observation is not fully clarified...
  87. doi PKCδ as a regulator for TGF-β-stimulated connective tissue growth factor production in human hepatocarcinoma (HepG2) cells
    Su Jin Lee
    School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu, 702 701 Korea
    Biochem J 456:109-18. 2013
    ..These findings indicated that PKCδ plays a critical role in TGF-β1-induced CTGF production in HepG2 cells. ..
  88. doi Sphingosine suppresses mesothelioma cell proliferation by inhibiting PKC-δ and inducing cell cycle arrest at the G(0)/G(1) phase
    Hisaya Okuwa
    Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Japan
    Cell Physiol Biochem 30:995-1004. 2012
    ..Sphingosine regulates cellular differentiation, cell growth, and apoptosis. The present study aimed at understanding sphingosine-regulated mesothelioma cell proliferation...
  89. doi Cisplatin increases B-cell-lymphoma-2 expression via activation of protein kinase C and Akt2 in endometrial cancer cells
    Alexandre Rouette
    Research Group in Molecular Oncology and Endocrinology, Department of Chemistry and Biology, Universite du Quebec a Trois Rivieres, Trois Rivieres, QC, Canada
    Int J Cancer 130:1755-67. 2012
    ..Our data suggest a novel regulation pathway of Bcl-2 by cisplatin, via the activation of PKC and Akt2, which has a profound impact on resistance to cisplatin-induced apoptosis in endometrial cancer cells...
  90. ncbi Identification of multiple, novel, protein kinase C-related gene products
    R H Palmer
    Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, London, UK
    FEBS Lett 356:5-8. 1994
    ..The origin and relationships of these predicted proteins is discussed...
  91. ncbi Phosphorylation of the ATP-sensitive, inwardly rectifying K+ channel, ROMK, by cyclic AMP-dependent protein kinase
    Z C Xu
    Laboratory of Molecular Physiology and Biophysics, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 271:9313-9. 1996
    ..Taken together, these results provide strong evidence that direct phosphorylation of the channel polypeptide by PKA is involved in channel regulation and PKA-dependent phosphorylation is essential for ROMK channel activity...
  92. ncbi HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system
    H Idriss
    Sealy Center for Molecular Science, The University of Texas Medical Branch Galveston, TX 77555 0851, USA
    Int J Biochem Cell Biol 31:1443-52. 1999
    ..Our results indicate that purified HIV-1 RT can be phosphorylated by several mammalian protein kinases in vitro and during expression in baculovirus infected insect cells...
  93. ncbi Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32
    P Storz
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 275:24601-7. 2000
    ..Together, these findings identify p32 as a novel, compartment-specific regulator of PKC mu kinase activity...
  94. ncbi Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization
    B Xiang
    National Laboratory of Medical Neurobiology, Fudan University Medical Center, Shanghai 200032, People s Republic of China
    J Biol Chem 276:4709-16. 2001
    ....
  95. ncbi HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes
    I W Park
    Division of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Blood 97:352-8. 2001
    ..These data indicate that the HIV-1 Tat protein may act as a protocytokine by causing the release of MCP-1 from the endothelial monolayer, and thereby facilitating monocyte transmigration into tissues via a PKC signaling pathway...
  96. ncbi Novel protein kinase C delta isoform insensitive to caspase-3
    Y Sakurai
    Department of Biochemistry, Tokyo Dental College, Chiba, Japan
    Biol Pharm Bull 24:973-7. 2001
    Protein kinase C delta (PKC delta) plays a key regulatory role in a variety of cellular functions, including apoptosis, as well as cell growth and differentiation...
  97. ncbi Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch
    M Liang
    Department of Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0564, Cincinnati, Ohio 45267 0564, USA
    Biochemistry 40:15031-7. 2001
    ..This represents one mechanism by which cells route stimuli directed to multifunctional receptors to selected effectors so as to attain finely targeted signaling...
  98. ncbi Inhibition of histone acetyltransferase function of p300 by PKCdelta
    L W Yuan
    Department of Physiology and Biophysics, School of Medicine, Boston University, 715 Albany St, MA 02118, USA
    Biochim Biophys Acta 1592:205-11. 2002
    ..These findings identify a new signal transduction pathway by which PKCdelta may inhibit cell growth and promote cellular differentiation...
  99. ncbi Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta
    Ingo Ringshausen
    Third Department of Medicine, Technical University of Munich, Germany
    Blood 100:3741-8. 2002
    ..We conclude that activated PI-3K might be important in the pathogenesis of B-CLL, and survival signals might be mediated via PKCdelta. Therefore, inhibition of PI-3K or PKCdelta may be an innovative approach to treat B-CLL...
  100. ncbi Reciprocal effects of C/EBPalpha and PKCdelta on JunB expression and monocytic differentiation depend upon the C/EBPalpha basic region
    Huaitian Liu
    Division of Pediatric Oncology, Johns Hopkins University, Baltimore, MD, USA
    Blood 101:3885-92. 2003
    ..Exogenous JunB restored AP-1 DNA-binding but did not prevent inhibition of macrosialin expression by C/EBPalpha-ER, indicating that JunB is not the only target relevant to inhibition of monopoiesis by C/EBPalpha...
  101. ncbi Different regulation of PKC isoenzymes and MAPK by PSK and IL-2 in the proliferative and cytotoxic activities of the NKL human natural killer cell line
    Angel Garcia-Lora
    Servicio de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Avda de las Fuerzas Armadas 2, 18014 Granada, Spain
    Cancer Immunol Immunother 52:59-64. 2003
    ..IL-2 decreased the expression of ERK2, whereas PSK did not, and both agents increased the expression of ERK3. These results shown that PSK and IL-2 produce different variations in PKC isoenzymes and MAPK in NKL cells...

Research Grants30

  1. Manuela Bartoli; Fiscal Year: 2016
    ..Aim1. Test the hypothesis that PKCd-dependent TXNIP-SerP contributes to retinal OxS, inflammation and progression to DR. Aim2...
  2. Satya P Kunapuli; Fiscal Year: 2016
    ..For example, previous studies from this lab have shown that PKCd plays a negative regulatory role in GPVI- mediated dense granule release whereas it promotes secretion downstream ..
  3. ANUMANTHA GOUNDER KANTHASAMY; Fiscal Year: 2015
    ..mitochondrial-dependent apoptotic signaling in manganese neurotoxicity and found that protein kinase C-delta (PKCd), a member of the novel PKC isoform family, is persistently activated by caspase-3 to promote apoptosis during ..
  4. Bo Liu; Fiscal Year: 2014
    ..The pro-inflammatory function of PKCd is mediated through monocyte chemoattactant protein-1 (MCP-1)...
  5. Neuroinflammatory Mechanisms in the Progression of Parkinson's Disease
    Arthi Kanthasamy; Fiscal Year: 2012
    ..in the preliminary data, we have identified a member of the novel PKC isoform family, protein kinase C-delta (PKCd), as a critical regulator of release of a key proinflammatory cytokine TNFa from microglial cells...
  6. Stephen M Black; Fiscal Year: 2016
    ..Our new in vitro data indicate that ET-1-mediated activation of PKCd activity blocks the shear mediated increase in NO generation...
  7. Marcelo G Kazanietz; Fiscal Year: 2015
    ..neoplastic (PIN) lesions, whereas no obvious phenotype was observed in similar models that we developed for PKCa or PKCd overexpression...
  8. Douglas V Faller; Fiscal Year: 2014
    ..We previously discovered that over-activity of p21Ras signaling causes tumor cell apoptosis when PKCd activity is suppressed...
  9. ANUMANTHA GOUNDER KANTHASAMY; Fiscal Year: 2015
    ..by applicant): Our proposal aims to study a novel compensatory cell survival signaling pathway mediated by PKCd- PKD1 during the early stages of oxidative damage in the nigrostriatal dopaminergic system...
  10. ECM MATRIX, PROTEASE AND MELANOMA PROLIFERATION
    Yves DeClerck; Fiscal Year: 2007
    ..We discovered that down-regulation of Skp2 is dependent on protein kinase Cd (PKCd) activity and have obtained preliminary evidence suggesting that this ECM-dependent regulatory pathway is ..
  11. Neural control of expiratory duration in mammalian respiratory rhythm generation
    Kaiwen Kam; Fiscal Year: 2010
    ..neither pacemakers nor inhibition are essential for rhythm generation in the preBotzinger Complex, these elements may1 play a role in the effects of excitability on interburst interval...
  12. NEUROPROTECTIVE STRATEGIES AGAINST OXIDATIVE DAMAGE
    Anumantha Kanthasamy; Fiscal Year: 2009
    ..As outlined in the preliminary data, we have identified that protein kinase C-delta (PKCd), a member of the novel PKC isoform family, is an oxidative stress kinase that is highly expressed in nigral ..
  13. Targeting proapoptotic PKCdelta signaling in hepatocellular carcinoma
    Ching Shih Chen; Fiscal Year: 2010
    ..from our mechanistic finding that FTY720 triggers apoptosis in HCC cells by facilitating the activation of ROS-PKCd signaling...
  14. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Kimberly Romero; Fiscal Year: 2009
    ..Specific Aim 1: Determine which stages of nutrient transporter internalization and trafficking are affected by PKCd induction...
  15. Tyr-phosphorylation of PKC-delta and myocyte function
    Aaron Hinken; Fiscal Year: 2007
    ..proposal is to define the role of tyrosine residue phosphorylation in the regulation of protein kinase C delta (PKCd) in myocardial tissue...
  16. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2009
    ..The long-term objective is to develop strategies to intervene with these pathways to inhibit progression of breast cancer. ..
  17. SIGNAL TRANSDUCTION AND CELL DEATH REGULATION
    Alakananda Basu; Fiscal Year: 2004
    ....
  18. ANTI VIRAL THERAPEUTIC FOR EBV MALIGNANCIES
    DOUGLAS FALLER; Fiscal Year: 2002
    ..abstract_text> ..
  19. Pathological Role of bFGF in Human Adult Articular Cartilage
    HEE JEONG IM SAMPEN; Fiscal Year: 2010
    ..Better understanding of the regulation and function of the posttranslational modifier SUMO in traumatic/arthritic cartilage may provide new targets for therapeutic intervention in cartilage-associated joint diseases such as OA. ..
  20. Apoptosis in Sepsis: Regulation by TNF & delta-PKC
    Laurie Kilpatrick; Fiscal Year: 2006
    ..4: Assess the role of delta-PKC in regulating the assembly of TNFalpha anti-apoptotic signaling complexes and their association with the p60TNFR. ..
  21. Oral Therapeutic for Inducing Fetal Hemoglobin
    DOUGLAS FALLER; Fiscal Year: 2003
    ..Upon completion of preclinical studies, Investigational New Drug status will be obtained and the new therapeutic agent will be tested in human clinical trials. ..
  22. CANCER RESEARCH CENTER
    DOUGLAS FALLER; Fiscal Year: 2002
    ..abstract_text> ..
  23. Role of ghrelin in intestinal inflammation
    Dezheng Zhao; Fiscal Year: 2008
    ....
  24. Ras Oncoprotein-Targeted Therapy for Cancer
    DOUGLAS FALLER; Fiscal Year: 2009
    ..Finally, we will employ, and continuously refine, a new molecular strategy (a pharmacophore model) in the search for more active and more specific inducers of Ras-mediated apoptosis. ..
  25. Protective Mechanism of an Anti-Inflammatory Herbal Mix
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  26. CONTROL OF CELL GROWTH BY SHORT-CHAIN FATTY ACIDS
    DOUGLAS FALLER; Fiscal Year: 2004
    ..abstract_text> ..
  27. Development of a Ras-Targeted Cancer Therapeutic
    DOUGLAS FALLER; Fiscal Year: 2004
    ..Finally, we will employ, and continuously refine, a new molecular strategy (a pharmacophore model) in the search for more active and more specific inducers of Ras-mediated apoptosis. ..
  28. ORAL THERAPEUTICS FOR VIRAL MALIGNANCIES
    DOUGLAS FALLER; Fiscal Year: 2003
    ..abstract_text> ..
  29. EGF, Oxidants & Intestinal Barrier Integrity
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..