PKC beta

Summary

Gene Symbol: PKC beta
Description: protein kinase C beta
Alias: PKC-beta, PKCB, PRKCB1, PRKCB2, protein kinase C beta type, PKC-B, protein kinase C, beta 1 polypeptide
Species: human

Top Publications

  1. pmc Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
    X Fang
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:11960-5. 2000
  2. ncbi Glycogen synthase kinase-3: properties, functions, and regulation
    A Ali
    Division of Experimental Therapeutics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Chem Rev 101:2527-40. 2001
  3. doi PKC delta in preeclamptic placentas promotes Bax dissociation from 14-3-3 zeta through 14-3-3 zeta phosphorylation
    J K Park
    Department of Obstetrics and Gynecology, College of Medicine, Gyeongsang National University, 90 Chilam dong, Jinju 660 702, Republic of Korea
    Placenta 29:584-92. 2008
  4. pmc Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3
    Julio C B Ferreira
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e33175. 2012
  5. ncbi Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells
    N A Patel
    Department of Biochemistry and Molecular Biology, University of South Florida, Tampa, Florida 33612, USA
    J Biol Chem 276:22648-54. 2001
  6. pmc Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway
    Xianjun Fang
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 22:2099-110. 2002
  7. ncbi Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes
    N Goode
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, United Kingdom
    J Biol Chem 267:16878-82. 1992
  8. ncbi Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals
    E Oancea
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 95:307-18. 1998
  9. ncbi Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation
    X Feng
    Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 275:17024-34. 2000
  10. pmc Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization
    Kiyoshi Suzuma
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:721-6. 2002

Research Grants

Detail Information

Publications262 found, 100 shown here

  1. pmc Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
    X Fang
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:11960-5. 2000
    ....
  2. ncbi Glycogen synthase kinase-3: properties, functions, and regulation
    A Ali
    Division of Experimental Therapeutics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Chem Rev 101:2527-40. 2001
  3. doi PKC delta in preeclamptic placentas promotes Bax dissociation from 14-3-3 zeta through 14-3-3 zeta phosphorylation
    J K Park
    Department of Obstetrics and Gynecology, College of Medicine, Gyeongsang National University, 90 Chilam dong, Jinju 660 702, Republic of Korea
    Placenta 29:584-92. 2008
    ..In addition, we explored the mechanism of Bax dissociation from 14-3-3, hypothesizing that PKC-mediated phosphorylation of 14-3-3 results in dissociation of Bax from 14-3-3 proteins, and leads to apoptosis...
  4. pmc Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3
    Julio C B Ferreira
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e33175. 2012
    ..PQC disruption by increased PKCβII activity in vivo appears to contribute to the pathophysiology of heart failure, suggesting that PKCβII inhibition may benefit patients with heart failure. (218 words)...
  5. ncbi Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells
    N A Patel
    Department of Biochemistry and Molecular Biology, University of South Florida, Tampa, Florida 33612, USA
    J Biol Chem 276:22648-54. 2001
    ....
  6. pmc Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway
    Xianjun Fang
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 22:2099-110. 2002
    ..LPA and potentially other natural ligands primarily utilize a PKC-dependent pathway to modulate GSK-3...
  7. ncbi Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes
    N Goode
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, United Kingdom
    J Biol Chem 267:16878-82. 1992
    ..Phosphorylation of GSK-3 beta by PKC results in its specific inactivation. These results are consistent with a model in which activation of PKC stimulates c-Jun DNA binding by inhibiting its phosphorylation by GSK-3 beta...
  8. ncbi Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals
    E Oancea
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 95:307-18. 1998
    ..The properties of this molecular decoding machine make PKCgamma responsive to persistent diacylglycerol increases combined with high- but not low-frequency calcium spikes...
  9. ncbi Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation
    X Feng
    Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 275:17024-34. 2000
    ....
  10. pmc Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization
    Kiyoshi Suzuma
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:721-6. 2002
    ..dramatic increase in the angiogenic response to oxygen-induced retinal ischemia in transgenic mice overexpressing PKC beta 2 isoform and a significant decrease in retinal neovascularization in PKC beta isoform null mice...
  11. ncbi The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C
    Tianyan Gao
    Department of Pharmacology, University of California, La Jolla, California 92093 0640, USA
    J Biol Chem 277:31585-92. 2002
    ..Disruption of this interaction prevents re-phosphorylation and targets the enzyme for down-regulation...
  12. ncbi PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
    Thomas T Su
    The Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Nat Immunol 3:780-6. 2002
    ..Together, these data define an essential role for PKC-beta in BCR survival signaling and highlight PKC-beta as a key therapeutic target for B-lineage malignancies...
  13. ncbi Protein kinase Cbeta1, a major regulator of TCR-CD28-activated signal transduction leading to IL-2 gene transcription and secretion
    Uschi E Dreikhausen
    Institute of Pharmacology, Medical School Hannover, 30623 Hannover, Germany
    Int Immunol 15:1089-98. 2003
    ..The data indicate a highly specific function of PKCbeta for regulation of TCR-CD28 induced-signaling, IL-2 gene expression and secretion in Jurkat T cells...
  14. ncbi cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes
    Kevin P Becker
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 278:52747-54. 2003
    ..These results identify a novel site for cPKC translocation and define a novel function for the sustained activation of PKCalpha and betaII in regulation of recycling components...
  15. ncbi B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetaII
    Simon T Abrams
    Department of Haematology, University of Liverpool, UK
    Blood 109:1193-201. 2007
    ..Taken together, these results demonstrate that overexpressed active PKCbetaII plays a role in the regulation and outcome of BCR signals that can be important for the progression of CLL...
  16. ncbi RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function
    Alice Vallentin
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:1650-7. 2007
    ..Our results suggest that RBCK1 binds PKCbetaI and is a key regulator of PKCbetaI function in cells and that, together with PKCbetaII, the three proteins are essential for developmental hypertrophy of cardiac myocytes...
  17. doi PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia
    Claudia Holler
    Laboratory for Immunological and Molecular Cancer Research, 3rd Medical Department for Hematology, Oncology, Hemostasiology, Infectious Diseases and Rheumatology, University Hospital Salzburg, Salzburg, Austria
    Blood 113:2791-4. 2009
    ..Moreover, targeting of PKCbeta with the specific inhibitor enzastaurin led to killing of human CLL samples in vitro. We thus propose that PKCbeta may be a relevant target for the treatment of CLL...
  18. doi Recruitment of PKC-betaII to lipid rafts mediates apoptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70
    C Meyer Zum Büschenfelde
    3rd Department of Medicine, Hematology and Oncology, Technical University, Munich 81675, Germany
    Leukemia 24:141-52. 2010
    ..We provide evidence that this compound is highly active in leukemic cells and augments the cytotoxic effects of standard chemotherapeutic drugs...
  19. ncbi 14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells
    M V Autieri
    Department of Cardiology and Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    DNA Cell Biol 18:555-64. 1999
    ..Thus, 14-3-3gamma may represent a signal transduction protein that is regulated transcriptionally and post-transcriptionally by growth factors...
  20. ncbi Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor
    N Geijsen
    Department of Pulmonary Diseases, University Hospital Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands
    Oncogene 18:5126-30. 1999
    ..Together, these findings suggest a novel role for RACK1 as a possible adapter molecule associating with the intracellular domain of cytokine receptors...
  21. pmc PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization
    S W Kang
    Department of Pediatrics, University of California, Los Angeles, CA 90095 1752, USA
    EMBO J 20:5692-702. 2001
    ..These findings provide a novel mechanism whereby reversible translocation of Btk/Tec kinases regulates the threshold for immunoreceptor signaling and thereby modulates lymphocyte activation...
  22. ncbi Intestinal sugar absorption is regulated by phosphorylation and turnover of protein kinase C betaII mediated by phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent pathways
    Philip A Helliwell
    Department of Biology Area 3, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 278:28644-50. 2003
    ..These findings suggest possible mechanisms for short term control of intestinal sugar absorption by insulin and amino acids...
  23. ncbi Protein kinase C-betaII represses hepatocyte growth factor-induced invasion by preventing the association of adapter protein Gab1 and phosphatidylinositol 3-kinase in melanoma cells
    Masahiro Oka
    Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Invest Dermatol 128:188-95. 2008
    ..These results indicate that the HGF signaling process from Gab1 to PI3K is negatively regulated by PKC-betaII, and its loss is critical for melanoma cells to gain invasive potential...
  24. pmc Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis
    Jeewon Kim
    Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, California 94305 5174, USA
    Cancer Res 68:6831-9. 2008
    ..Our results suggest that a PKCbetaII inhibitor such as betaIIV5-3 may be used to reduce prostate cancer growth by targeting both angiogenesis and tumor cell growth...
  25. pmc Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome
    Miren David
    Instituto de Investigaciones Biomedicas, Madrid Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, c Arturo Duperier 4, 28029 Madrid, Spain
    J Biol Chem 287:21416-28. 2012
    ..5, K(v)β1.3, the receptor for activated C kinase (RACK1), PKCβI, PKCβII, and PKCθ in HEK293 cells. A very similar K(v)1.5 channelosome was found in rat ventricular tissue but not in atrial tissue...
  26. ncbi Identification and characterization of protein kinase C zeta-immunoreactive proteins
    B G Allen
    Department of Medical Biochemistry, Faculty of Medicine, University of Calgary, Alberta, Canada
    J Biol Chem 269:29288-98. 1994
    ..The 81.3-kDa protein copurified with PKC alpha, and the 79.4-kDa protein copurified with PKC beta and PKC gamma...
  27. ncbi Immunochemical identification and translocation of protein kinase C zeta in human neutrophils
    P M Dang
    Laboratoire d'Hematologie, INSERM U294, CHU Xavier Bichat, Paris, France
    FEBS Lett 349:338-42. 1994
    ..PKC zeta was apparently abundant, like PKC beta, whereas PKC delta, -epsilon, and -gamma were not detectable...
  28. ncbi Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms
    M G Franz
    Department of Surgery, University of South Florida College of Medicine, Tampa, USA
    Ann Surg Oncol 3:564-9. 1996
    ..CONCLUSIONS: TNF-alpha-induced growth arrest and differentiation in HPAC cells is associated with the selective downregulation of PKC-alpha and upregulation of PKC-gamma...
  29. ncbi The identification of four protein kinase C isoforms in human glioblastoma cell lines: PKC alpha, gamma, epsilon, and zeta
    H Xiao
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio
    J Neurosurg 81:734-40. 1994
    ..These data suggest that alteration in the expression of PKC-epsilon and PKC-zeta could be a factor in the conversion of normal glial cells to glioblastomas...
  30. ncbi Differential activation of PKC-delta and -zeta by alpha 1-adrenergic stimulation in human airway epithelial cells
    C M Liedtke
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106-4948, USA
    Am J Physiol 273:C937-43. 1997
    ..Methoxamine selectively induced a sustained increase in PKC-zeta activity but only a transient increase in PKC-delta. These results suggest that PKC-delta and -zeta mediate hormonal activation of Na-Cl-K cotransport...
  31. ncbi Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes
    G Bandyopadhyay
    J. A. Haley Veterans Hospital and the Department of Internal Medicine, University of South Florida College of Medicine, Tampa 33612, USA
    Endocrinology 138:4721-31. 1997
    ..Collectively, our findings suggest that, whereas PKC-zeta is a reasonable candidate to participate in insulin stimulation of glucose transport, DAG-sensitive PKCs are unlikely participants...
  32. ncbi Ischemic preconditioning promotes a transient, but not sustained translocation of protein kinase C and sensitization of adenylyl cyclase
    Gregor Simonis
    Dept of Cardiology, Dresden University of Technology, Fetscherstr 76, 01307 Dresden, Germany
    Basic Res Cardiol 98:104-13. 2003
    ..The goal of this study was, therefore, to determine the activation of those signaling molecules after 1 - 3 cycles of myocardial ischemia and reperfusion...
  33. doi Evaluation of renal gene expression of protein kinase C (PKC) isoforms in diabetic and nondiabetic proliferative glomerular diseases
    Salwa Ibrahim
    Department of Internal Medicine, CairoUniversity, Egypt
    ScientificWorldJournal 8:835-44. 2008
    ..b>PKC beta was reported to have a positive role in B-lymphocyte activity through activation of NF-kB, leading to various ..
  34. pmc Insulin increases mRNA levels of protein kinase C-alpha and -beta in rat adipocytes and protein kinase C-alpha, -beta and -theta in rat skeletal muscle
    A Avignon
    Department of Internal Medicine and Biochemistry, J A Haley Veterans Hospital, University of South Florida College of Medicine, Tampa 33612, USA
    Biochem J 308:181-7. 1995
    ..This mechanism of increasing mRNA may be important in maintaining PKC levels during the continued action of insulin...
  35. ncbi Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: Relationship between its expression and prognosis
    Katsuhito Kamimura
    First Department of Pathology, Fukushima Medical University School of Medicine, Hikariga oka, Fukushima, Japan
    Pathol Int 54:224-30. 2004
    ..In the reactive lymphoid tissues, PKC beta II-positive cells were found in the mantle zones and marginal zones, and centroblasts and centrocytes in the ..
  36. ncbi PKC isoenzymes in the chicken lens and TPA-induced effects on intercellular communication
    V M Berthoud
    Department of Pediatrics, University of Chicago, Illinois 60637 1470, USA
    Invest Ophthalmol Vis Sci 41:850-8. 2000
    ....
  37. ncbi ['Hyperglycaemic memory' in human umbilical vein endothelial cells mediated by interacting loop of protein kinase Cbeta(2)-reactive oxygen species]
    Xue Bo Lin
    Department of Endocrinology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China
    Zhonghua Nei Ke Za Zhi 49:239-44. 2010
    ....
  38. doi Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells
    E Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    Br J Dermatol 160:16-25. 2009
    ..We have recently shown in immune cells that decreased expression of the receptor for activated C kinase (RACK)-1 underlies defective protein kinase C (PKC) activation and functional immune impairment with ageing...
  39. ncbi Expression of protein kinase C isoenzymes alpha, betaI, and delta in subtypes of intercalated cells of mouse kidney
    Wan Young Kim
    Dept of Anatomy and MRC for Cell Death Disease Research Center, College of Medicine, The Catholic Univ of Korea, Seoul, Korea, 505, Banpo dong, Seocho Ku, Seoul 137 701, Korea
    Am J Physiol Renal Physiol 291:F1052-60. 2006
    ..In summary, this study demonstrates distinct and differential expression patterns of PKC-alpha, -beta(I), and -delta in the three subtypes of intercalated cells in the mouse kidney...
  40. ncbi The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage
    M F Rabbi
    Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Virology 245:257-69. 1998
    ....
  41. ncbi Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate
    Rumelia Koren
    Department of Pathology, Hasharon Hospital, Petah Tikva 49100, Israel
    Oncol Rep 11:321-6. 2004
    ..Expression of PKC beta was examined in additional 3 BPH and 3 PCa using Western blot analysis...
  42. doi Proteomic screening of antioxidant effects exhibited by radix Salvia miltiorrhiza aqueous extract in cultured rat aortic smooth muscle cells under homocysteine treatment
    Yu Chiang Hung
    Graduate Institute of Clinical Medical Sciences, Kaohsiung Division, Chang Gung University, Kaohsiung, Taiwan
    J Ethnopharmacol 124:463-74. 2009
    ....
  43. ncbi Overexpression of protein kinase C isoforms protects RAW 264.7 macrophages from nitric oxide-induced apoptosis: involvement of c-Jun N-terminal kinase/stress-activated protein kinase, p38 kinase, and CPP-32 protease pathways
    C D Jun
    Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, Chonbuk, Korea
    J Immunol 162:3395-401. 1999
    ..Therefore, we conclude that PKC protects NO-induced apoptotic cell death, presumably nullifying the NO-mediated activation of JNK/SAPK, p38 kinase, and CPP32-like protease in RAW 264.7 macrophages...
  44. ncbi The use of antisense strategy to modulate human melanogenesis
    Kristell Lazou
    LVMH Recherche Parfums Christian Dior, St jean de braye, France
    J Drugs Dermatol 6:s2-7. 2007
    ..The lightening effect was evaluated by comparing chromametric and mexametric parameters before treatment, after 4 weeks, and after 8 weeks...
  45. ncbi Regional and cellular distribution of protein kinase C in rat cerebellar Purkinje cells
    N H Barmack
    Neurological Sciences Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Comp Neurol 427:235-54. 2000
    ..These data identify circuitry that is unique to cerebellar-vestibular interactions...
  46. ncbi Amino acids injure mesangial cells by advanced glycation end products, oxidative stress, and protein kinase C
    Katherine R Tuttle
    The Heart Institute of Spokane and Sacred Heart Medical Center, Spokane, Washington 99204, USA
    Kidney Int 67:953-68. 2005
    ..Increased levels of amino acids could injure cells by providing free amino groups for glycation reactions leading to advanced glycation end products (AGEs)...
  47. ncbi Nicergoline stimulates protein kinase C mediated alpha-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells
    A Cedazo-Minguez
    Karolinska Institutet, Neurotec, Novum, Huddinge, Sweden
    Neurochem Int 35:307-15. 1999
    ..nicergoline (50 microM) and PdBu (1 microM) both induced translocation of PKC alpha, gamma and epsilon, but not PKC beta. The involvement of PKC in mediating nicergoline stimulated APPs release was also studied using specific ..
  48. pmc Phenotypic screen of early-developing larvae of the blood fluke, schistosoma mansoni, using RNA interference
    M M Mourão
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS Negl Trop Dis 3:e502. 2009
    ..Out of 22 nonphenotype-expressing dsRNA treatments (myosin, PKCB, HEXBP, calcium channel, Sma2, RHO1, PKC receptor, DHHC, PepcK, calreticulin, calpain, Smeg, 14.3...
  49. ncbi Alpha-melanocyte stimulating hormone-induced pigmentation is blocked by depletion of protein kinase C
    H Y Park
    Department of Dermatology, Boston University School of Medicine, Massachusetts 02118, USA
    Exp Cell Res 227:70-9. 1996
    ....
  50. ncbi Gene expression analysis illuminates the transcriptional programs underlying the functional activity of ex vivo-expanded granulocytes
    Li Ting Huang
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, USA
    Physiol Genomics 31:114-25. 2007
    ..Lower expression of Lyn, Cdc42, pleckstrin, and PKC beta(I) by EXE granulocytes may explain decreased phagocytosis...
  51. ncbi Selective impairment of protein kinase C isotypes in murine macrophage by Leishmania donovani
    S Bhattacharyya
    Department of Microbiology, Bose Institute, Calcutta, India
    Mol Cell Biochem 216:47-57. 2001
    ..This result was further confirmed by using isotype specific pseudosubstrate inhibitors of Ca-dependent PKC beta and Ca-independent PKC zeta...
  52. ncbi Stimulation of respiratory burst by cyclocommunin in rat neutrophils is associated with the increase in cellular Ca2+ and protein kinase C activity
    J P Wang
    Department of Medical Research, Taichung Veterans General Hospital, Taiwan
    Free Radic Biol Med 26:580-8. 1999
    ..Collectively, these results indicate that the stimulation of respiratory burst by cyclocommunin is probably mediated by the synergism of PKC activation and [Ca2+]i elevation in rat neutrophils...
  53. ncbi HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress
    K Yasunari
    Department of Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 21:937-42. 2001
    ....
  54. ncbi Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D
    Pamela J Mansfield
    Department of Pediatrics, Division of Hematology Oncology, University of Michigan, Ann Arbor 48109, USA
    Blood 99:1434-41. 2002
    ..Ceramide may affect protein interactions with PLD in the plasma membrane, thereby attenuating PMN activation...
  55. ncbi Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells
    G Condorelli
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
    Diabetes 50:1244-52. 2001
    ..We conclude that activation of classic PKCs, mainly PKC-alpha, inhibits PKC-zeta and may mediate the action of PED on glucose uptake in L6 skeletal muscle cells...
  56. ncbi Receptor for advanced glycation end products (RAGEs) and experimental diabetic neuropathy
    Cory Toth
    University of Calgary, Department of Clinical Neurosciences, Room 155, 3330 Hospital Dr, N W, Calgary, Alberta T2N 4N1, Canada
    Diabetes 57:1002-17. 2008
    ..We studied experimental diabetic neuropathy and its relationship with RAGE expression using streptozotocin-induced diabetic mice including a RAGE(-/-) cohort exposed to long-term diabetes compared with littermates without diabetes...
  57. ncbi The phosphoinositide-phospholipase C (PI-PLC) pathway in the mouse oocyte
    Brigitte Lefevre
    INSERM U566 CEA DRR LGAG Univ Paris 7, Batiment 05, Route du Panorama, F 92260, Fontenay aux Roses, France
    Crit Rev Eukaryot Gene Expr 17:259-69. 2007
    ..Because a similar circuit is observed for protein kinase C alpha (PKC alpha), PKC beta 1, PKC beta 2, and active mitogen-activated protein kinase, it is tempting to envisage that a feedback loop ..
  58. doi Role of basic fibroblast growth factor (FGF-2) in diabetic nephropathy and mechanisms of its induction by hyperglycemia in human renal fibroblasts
    Radovan Vasko
    Department of Nephrology and Rheumatology, Georg August Univ Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Am J Physiol Renal Physiol 296:F1452-63. 2009
    ..Our results implicate a role of FGF-2 in high glucose-altered molecular signaling in pathogenesis of diabetic renal disease...
  59. pmc Mobilization of protein kinase C in macrophages induced by Listeria monocytogenes affects its internalization and escape from the phagosome
    Sandra J Wadsworth
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6076, USA
    Infect Immun 70:4650-60. 2002
    ..for translocation of protein kinase C delta (PKC delta) to the periphery of J774 cells and for translocation of PKC beta II to early endosomes beginning within the first minute after addition of bacteria to the culture medium...
  60. pmc Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function
    J C Hsieh
    Department of Biochemistry, University of Arizona, Tucson 85724
    Proc Natl Acad Sci U S A 88:9315-9. 1991
    ..Therefore, the present results link the PKC signal transduction pathway of growth regulation and tumor promotion to the phosphorylation and function of VDR...
  61. ncbi Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7
    T P Dooley
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228
    Genomics 18:440-3. 1993
    ..The results indicated that STP is localized proximal to the gene for protein kinase C, beta 1 polypeptide (PRKCB1), in the region from the distal portion of 16p11.2 to p12.1...
  62. pmc Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of human myometrium after gestation
    Hiroshi Ozaki
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Yayoi 1 1 1, Tokyo 113 8657, Japan
    Br J Pharmacol 140:1303-12. 2003
    ..LY333531 (1 microM), a specific inhibitor of PKC beta, also inhibited the PDBu-induced contraction in the pregnant myometrium. 3...
  63. ncbi High glucose suppresses expression of equilibrative nucleoside transporter 1 (ENT1) in rat cardiac fibroblasts through a mechanism dependent on PKC-zeta and MAP kinases
    Marzena Grden
    Department of Molecular Medicine, Medical University of Gdansk, Gdansk, Poland
    J Cell Physiol 215:151-60. 2008
    ..These findings indicate that high glucose suppresses the expression of ENT1 in CFs by NO independent manner involving the signaling through PKC-zeta, Raf-1, MEK, and p38 MAPK pathways...
  64. ncbi Correlations of mRNA expression and in vitro chemosensitivity to enzastaurin in freshly explanted human tumor cells
    Axel Rainer Hanauske
    St Georg Hospital, Lohmühlenstr 5, 20099 Hamburg, Germany
    Invest New Drugs 26:215-22. 2008
    ....
  65. ncbi Differential activation by daphnetoxin and mezerein of PKC-isotypes alpha, beta I, delta and zeta
    L Saraiva
    Department of Pharmacology, CEQOFFUP, Faculty of Pharmacy, University of Porto, Porto, Portugal
    Planta Med 67:787-90. 2001
    ..Mezerein inhibited the growth of yeast expressing PKC alpha (IC(50) = 1190 +/- 237 nM; n = 20), PKC beta I (IC(50) = 908 +/- 46 nM; n = 20), and PKC delta (IC(50) = 141 +/- 25 nM; n = 20) but not of yeast expressing ..
  66. ncbi Two polychlorinated hydrocarbons cause phospholipid-dependent protein kinase C activation in vitro in the absence of calcium
    S A Rotenberg
    Institute of Cancer Research, Columbia University, New York, NY 10032
    Mol Carcinog 4:477-81. 1991
    ..Future studies are required to determine the relevance of PKC activation by kepone and dicofol to the known carcinogenicity of these compounds...
  67. ncbi Upregulated renal adenosine A1 receptors augment PKC and glucose transport but inhibit proliferation
    R Coulson
    Department of Veterans Affairs, James A Haley Veterans Hospital, Tampa, Florida 33612, USA
    Am J Physiol 270:F263-74. 1996
    ..It is concluded that chronic exposure of proximal tubule cells to caffeine or CPT augments PKC and sodium-glucose transport but retards cell proliferation mainly via adenosine A1 receptor-mediated mechanisms...
  68. ncbi Microgravity modifies protein kinase C isoform translocation in the human monocytic cell line U937 and human peripheral blood T-cells
    Jason P Hatton
    Laboratory of Cell Growth, Veterans Affairs Medical Center, Mail Code 151F, San Francisco, California 94121, USA
    J Cell Biochem 87:39-50. 2002
    ..In microgravity, the translocation of PKC beta II, delta, and epsilon in response to phorbol esters was reduced in microgravity compared to 1 g, but was ..
  69. ncbi In vivo expression of classic PKC isoforms in the rat dental follicle as related to tooth eruption
    Shaomian Yao
    Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University Baton Rouge, Louisiana 70803, USA
    Connect Tissue Res 45:216-21. 2004
    ..Injection of a PKC activator, phorbol 12-myristate 13-acetate (PMA), at late postnatal days, slightly accelerated first mandibular molar eruption. This study suggests that PKC isoforms may be involved in the regulation of tooth eruption...
  70. doi Enhancement of calcium transport in Caco-2 monolayer through PKCzeta-dependent Cav1.3-mediated transcellular and rectifying paracellular pathways by prolactin
    Narongrit Thongon
    Consortium for Calcium and Bone Research COCAB, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Am J Physiol Cell Physiol 296:C1373-82. 2009
    ..3 and PMCA, presumably through PI3K and PKC(zeta) pathways, while the enhanced voltage-dependent calcium transport occurred through PI3K and ROCK pathways...
  71. doi Dehydroepiandrosterone sulfate directly activates protein kinase C-beta to increase human neutrophil superoxide generation
    David J Radford
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
    Mol Endocrinol 24:813-21. 2010
    ....
  72. ncbi Prevention of diabetes-induced abnormal retinal blood flow by treatment with d-alpha-tocopherol
    M Kunisaki
    Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Biofactors 7:55-67. 1998
    ..05). Western blot analysis showed that the membranous PKC beta II isoform was significantly increased by 133 +/- 45% (p < 0.05)...
  73. ncbi Protein kinase C-beta activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain
    H Y Park
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 274:16470-8. 1999
    ..We conclude that PKC-beta activates tyrosinase directly by phosphorylating serine residues at positions 505 and 509 in the cytoplasmic domain of this melanosome-associated protein...
  74. ncbi Age-dependent activation of PKC isoforms by angiotensin II in the proximal nephron
    D M Boesch
    Division of Hypertension and Vascular Research, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Am J Physiol Regul Integr Comp Physiol 281:R861-7. 2001
    ..05). Maximum specific binding and affinity of ANG II receptors were not significantly different between young and adult rats. We concluded that the primary PKC isoform activated by ANG II changes during maturation...
  75. ncbi Protein kinase C-associated kinase (PKK) mediates Bcl10-independent NF-kappa B activation induced by phorbol ester
    Akihiro Muto
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 277:31871-6. 2002
    ..a recently described kinase of unknown function that was identified on the basis of its specific interaction with PKC beta. PKK contains N-terminal kinase and C-terminal ankyrin repeats domains linked to an intermediate region...
  76. pmc Role of protein kinase C isozymes in the regulation of alpha1-adrenergic receptor-mediated contractions in ovine uterine arteries
    Hongying Zhang
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Biol Reprod 78:35-42. 2008
    ..and novel PRKC isozyme inhibitor GF109203X, PRKC isozyme-selective inhibitory peptides for conventional PRKC, PRKCB1, PRKCB2, and PRKCE...
  77. ncbi Differential expression of PKC beta II in the rat organ of Corti
    S Ladrech
    INSERM U583, Montpellier, France
    Eur J Neurosci 26:2922-30. 2007
    ..protein kinase C (PKC) in cochlear efferent neurotransmission, we studied the expression of the calcium-dependent PKC beta II isoform in the rat organ of Corti at different postnatal ages using immunofluorescence and immunoelectron ..
  78. doi Epstein-Barr virus latent membrane protein 1 mediates serine 25 phosphorylation and nuclear entry of annexin A2 via PI-PLC-PKCalpha/PKCbeta pathway
    Wei Luo
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, P R China
    Mol Carcinog 47:934-46. 2008
    ..level of annexin A2 by activating the phosphoinositide-specific phospholipase C (PI-PLC)-PKC alpha/PKC beta pathway, mainly through the activation of the PKCbeta pathway...
  79. ncbi Isozyme specific changes in the expression of protein kinase C isozyme (alpha-zeta) genes in the hippocampus of rats induced by kindling epileptogenesis
    W Kamphuis
    Institute of Neurobiology, University of Amsterdam, Netherlands
    Brain Res 702:94-100. 1995
    ..These results indicate an involvement of specific PKC-isoform gene expression in the induction of an epileptogenic focus, but not in the maintenance of the long-lasting kindled state...
  80. ncbi Mapping of a regulatory important site for protein kinase C phosphorylation in the N-terminal domain of annexin II
    M Jost
    University of Munster, Clinical Research Group for Endothelial Cell Biology, Munster, Germany
    Biochim Biophys Acta 1313:283-9. 1996
    ..Ser-II lies within the sequence mediating p11 binding, i.e. amino-acid residues 1 to 14 of annexin II, and phosphorylation at this site most likely leads to a direct spatial interference with p11 binding...
  81. ncbi Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate response and tyrosine phosphorylation of 140-kilodalton protein in mouse peritoneal macrophages
    H Shinji
    Department of Microbiology II, The Jikei University School of Medicine, Tokyo, Japan
    J Immunol 158:1370-6. 1997
    ..The results also suggest that the later IP3 change is considered to be mediated through a gamma2 type of phosphatidylinositol-specific PLC...
  82. ncbi Characterization of calcium-dependent forms of protein kinase C in adult rat ventricular myocytes
    M Wientzek
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
    Mol Cell Biochem 166:11-23. 1997
    ..Isoform-specific antisera indicated both PKC alpha and PKC beta were present...
  83. ncbi Coordinated movement of RACK1 with activated betaIIPKC
    D Ron
    Department of Neurology, University of California, San Francisco, California 94110 3518, USA
    J Biol Chem 274:27039-46. 1999
    ..We further show that association of RACK1 and betaIIPKC is required for the movement of both proteins. Our results suggest that RACK1 is a PKC shuttling protein that moves betaIIPKC from one intracellular site to another...
  84. ncbi Identification and characterization of PRKCBP1, a candidate RACK-like protein
    S C Fossey
    Molecular Genetics Program, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Mamm Genome 11:919-25. 2000
    ..The results of this analysis suggest that PRKCBP1 coding variations are uncommon and do not contribute to Type II diabetes in the general population...
  85. ncbi Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII
    M Mayadevi
    Rajiv Gandhi Centre for Biotechnology, Jagathy, Thiruvananthapuam, Kerala 695014, India
    Biochim Biophys Acta 1598:40-5. 2002
    ..However, CaMKII shows decreased affinity towards the closely related NR2A subunit due to an -Ile-Asn- motif present as a natural insertion in the analogous sequence on NR2A...
  86. ncbi Dynamics of glucose-induced membrane recruitment of protein kinase C beta II in living pancreatic islet beta-cells
    Paolo Pinton
    Henry Wellcome Signalling Laboratories and the Department of Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 277:37702-10. 2002
    ..Localized changes in PKCbetaII activity may thus have a role in the spatial control of insulin exocytosis...
  87. ncbi Protein kinase C beta isoenzymes in diabetic kidneys and their relation to nephroprotective actions of the ACE inhibitor lisinopril
    Imke L Pfaff
    Department of Pharmacology, Faculty of Medicine, University of Tubingen, Germany
    Kidney Blood Press Res 25:329-40. 2002
    ..o. twice daily for 4 weeks) on the expression of PKC beta 1 and PKC beta 2 in the renal cortex of female Sprague-Dawley rats...
  88. ncbi The potential role of PKC beta in diabetic retinopathy and macular edema
    Lloyd Paul Aiello
    Harvard Medical School and Joslin Diabetes Center, Boston, Massachussetts, USA
    Surv Ophthalmol 47:S263-9. 2002
    ..in the development of retinopathy, activation of protein kinase C (PKC), specifically the beta isoform of PKC (PKC beta), is implicated for both the early and late-stage manifestations of retinopathy...
  89. ncbi Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo
    Yan Liu
    Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 279:45556-63. 2004
    ....
  90. ncbi Effects of the antiandrogen flutamide on the expression of protein kinase C isoenzymes in LNCaP and PC3 human prostate cancer cells
    Leire Montalvo
    Departamento de Bioquimica y Biologia Molecular, Universidad de Alcala, E 28871 Alcala de Henares, Spain
    Biosci Rep 24:11-21. 2004
    ....
  91. ncbi CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade
    Miguel E Moreno-Garcia
    Departments of Cell Biology, Centro de Investigacion y Estudios Avanzados, Mexico D F Mexico
    J Immunol 174:2687-95. 2005
    ..Taken together, these data demonstrate that CD38 initiates a novel signaling cascade leading to Btk-, PC-PLC-, and phospholipase D-dependent, PLC-gamma2-independent, B lymphocyte activation...
  92. ncbi Novel protein kinase C-beta isoform selective inhibitor JTT-010 ameliorates both hyper- and hypoalgesia in streptozotocin- induced diabetic rats
    T Sasase
    Japan Tobacco, Central Pharmaceutical Research Institute, Murasaki cho, Takatsuki, Osaka, Japan
    Diabetes Obes Metab 7:586-94. 2005
    ....
  93. ncbi Conformational analysis in solution of protein kinase C betaII V5-1 peptide
    Choonshik Shin
    Bio Molecular Informatics Center, Konkuk University, Seoul 143 701, Republic of Korea
    Biochem Biophys Res Commun 337:154-9. 2005
    One of protein kinase C (PKC) isozymes, PKC beta binds to receptor for activated C kinase 1 (RACK1), and their complex is suggested to be translocated to melanosomes...
  94. ncbi The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration
    Yuri Volkov
    Dublin Molecular Medicine Centre and Department of Clinical Medicine, Trinity Centre College, Ireland
    Gastroenterology 130:482-92. 2006
    ..The aim of this study was to investigate the effect of the hepatitis C envelope protein E2 on LFA-1-stimulated T-cell migration and macrophage inflammatory protein (MIP-1alpha, MIP-1beta) secretion...
  95. ncbi Protein kinase C beta/early growth response-1 pathway: a key player in ischemia, atherosclerosis, and restenosis
    Shi Fang Yan
    Division of Surgical Science, Department of Surgery, Columbia University, New York, New York 10032, USA
    J Am Coll Cardiol 48:A47-55. 2006
    ....
  96. ncbi Acetylcholine activates protein kinase C-alpha in pulmonary venous smooth muscle
    Xueqin Ding
    Center for Anesthesiology Research, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Anesthesiology 106:507-14. 2007
    ..The authors investigated whether acetylcholine-induced contraction in pulmonary venous smooth muscle (PVSM) is associated with the activation of specific protein kinase C (PKC) isoforms...
  97. ncbi Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn
    Benchang Guo
    Center for Oncology and Cell Biology, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 178:4726-30. 2007
    ..These results indicate that the rottlerin-sensitive, Lyn-dependent alternate pathway, and the classical pathway, for BCR signaling operate in parallel when BCR engagement follows IL-4 exposure...
  98. doi PKCbetaII modulates translation independently from mTOR and through RACK1
    Stefano Grosso
    Molecular Histology and Cell Growth, HSR, 20132 Milan, Italy
    Biochem J 415:77-85. 2008
    ..Taken together the results of the present study show that PKCbetaII can act as a specific PKC isoform regulating translation, in an mTOR-independent fashion, possibly close to the ribosomal machinery...
  99. pmc The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains
    Hangxiu Xu
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 31:17074-90. 2011
    ..These findings demonstrate that gp120 contributes to synaptic dysfunction in the setting of HIV infection by interfering with NMDA receptor trafficking...
  100. doi Roles of ROS and PKC-βII in ionizing radiation-induced eNOS activation in human vascular endothelial cells
    Kimimasa Sakata
    Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 0194, Japan Department of Thoracic and Cardiovascular Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 0194, Japan
    Vascul Pharmacol 70:55-65. 2015
    ....
  101. doi Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing
    Charles Walther
    Department of Clinical Genetics, University and Regional Laboratories, Skane University Hospital, Lund University, Lund, Sweden
    Lab Invest 95:1071-6. 2015
    ..Finally, the study also shows that RNA-Seq is a promising tool for identifying gene fusions in FFPE tissues...

Research Grants58

  1. PKC-beta Regulation of the Dopmaine Transporter Trafficking
    Rong Chen; Fiscal Year: 2010
    ..abstract_text> ..
  2. PROTEIN KINASE C BASED ANTILEUKEMIC THERAPY
    Richard Stone; Fiscal Year: 1999
    ..of the TPA-resistant HL-60 cell subline (HL- 525) markedly increases the relatively low constitutive levels of PKCb mRNA and protein found in this variant...
  3. SYSTEMIC VEGF AND DIABETIC RETINOPATHY--CLINICAL TRIALS
    Lloyd Aiello; Fiscal Year: 2000
    ..Retinopathy level and progression have been documented. These studies will provide the first prospective evaluation of plasma VEGF and its correlation with retinopathy progression and onset of microalbuminuria. ..
  4. Retinal Oxygenation in Diabetic Retinopathy
    BRUCE BERKOWITZ; Fiscal Year: 2004
    ..In addition, we will compare retinal deltaPO2 in normal mice, transgenic mice that overexpress PKC beta II, diabetic mice, and diabetic PKC beta II-knockout mice...
  5. Role of PKCtheta in CD3/28-stimulated HIV-1 replication
    Caitlin Sedwick; Fiscal Year: 2004
    ..of NF-kB can be stimulated by signaling through CD3/CD28 costimulation, and the serine/threonine kinase PKCB plays an obligatory role in the activation of NF-KB by CD3/CD28 signaling...
  6. Effects of TPA on Leukemia and Solid Tumors
    Allan Conney; Fiscal Year: 2006
    ..alone or as synergistic combinations are mediated through changes in the levels and translocation of PKC alpha, PKC beta and PKC delta, and on the expression of mRNAs for PKC alpha, PKC beta and PKC delta in TPA-sensitive HL-60 and ..
  7. ROLE OF P90RSK IN DIABETIC CARDIOMYOPATHY
    Jun Ichi Abe; Fiscal Year: 2003
    ..been strengthened by recent transgenic experiments in the heart where overexpression of the PKCB2 isoform but not PKCB, decreased cardiac function...
  8. The Angiotensin II-Induced JAK/STAT Pathway in Diabetes.
    Mario Marrero; Fiscal Year: 2005
    ..proteins in the aorta of STZ-induced diabetic rats is mediated by 1) AT1 receptor activation, 2) activation of PKC beta, 3) activation of the polyol pathway and the RAGE receptor, and 4) the over-production of reactive oxygen species...
  9. PKD2 involvement in the Btk-PKCBeta-NFkappaBeta pathway*
    David Rawlings; Fiscal Year: 2007
    ..This will entail parallel studies of PKCB and PKD expression and activity in human DLBCL cell lines and samples obtained from patients with good prognosis (..
  10. MECHANOENERGETICS OF HYPERTROPHY AND FAILURE
    Martin LeWinter; Fiscal Year: 2006
    ..This approach, combined with Aims I and II, should provide novel information about the details of thin filament phosphorylation in failing myocardium and may suggest new therapeutic targets. ..
  11. PKC Beta II: A target for colon cancer chemoprevention
    Nicole Murray; Fiscal Year: 2006
    ..In contrast, PKCB knockout (PKCBKO) mice are extremely resistant to colon carcinogenesis and re-expression of PKCBll only in the ..
  12. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2007
    ..FFA induced IR and ASVD by testing the following hypotheses: 1) that FFA induced activation of the serine kinases PKC beta II and delta and perhaps IkappaB kinase (IKK) in human muscle is associated with a decrease in insulin stimulated ..
  13. PKC Beta Inhibition With Gemcitabine And Radiation In Pancreas Cancer
    Edgar Ben Josef; Fiscal Year: 2008
    ..Based on its scientific merit and our institutional track record in translational research in pancreas cancer, we feel it is highly likely that this research will prove beneficial. [unreadable] [unreadable] [unreadable]..
  14. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    CHRISTINA DANIELS; Fiscal Year: 2007
    ..cytoplasm, interacts with Receptor for Activated C Kinase 1 (RACK1), interacts with separate complexes containing PKC beta II and protein phosphatase 2A (PP2A), and protects cells from apoptosis...
  15. Activation of the human neurtrophil
    HELEN KORCHAK; Fiscal Year: 2005
    ..V Establish the role of d-PKC in downregulation of signalling pathways triggered by the p60TNFR. Determine if d-PKC acts on a serine residue(s) in the juxtamembrane region or the death domain. ..
  16. EGF, Oxidants & Intestinal Barrier Integrity
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  17. Protective Mechanism of an Anti-Inflammatory Herbal Mix
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  18. Early Growth Response-1 (Egr-1), PKC Beta and Restenosis
    Shi Fang Yan; Fiscal Year: 2007
    ..focused on the role of the immediate early gene, early growth response-1 (egr-1) and its key upstream regulator, PKCb, in the response to acute arterial injury...
  19. LDL Modification in Diabetic Complications
    MARGO COHEN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. PKC Activation and Cardiovascular Disease in Diabetes
    George King; Fiscal Year: 2007
    ..2) to assess the role of PKC beta isoform activation in the development of atherosclerosis in apoE-KO mice by comparing the atherosclerotic lesions ..
  21. Modulation of K channels in renal collecting duct
    Wen Hui Wang; Fiscal Year: 2007
    ....
  22. Reducing Renal TGF-B in Diabetic Glomerulosclerosis
    MARGO COHEN; Fiscal Year: 2005
    ..abstract_text> ..
  23. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2005
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  24. Signal Transduction in Depression
    Richard Shelton; Fiscal Year: 2008
    ..These studies may shed light on important cellular mediators of depression and provide new targets for amelioration. [unreadable] [unreadable]..
  25. Regulation of asthma by Btk and family kinases
    Toshiaki Kawakami; Fiscal Year: 2008
    ..This is a poorly explored area in DC biology. Our efforts will hopefully identify novel targets for pharmaceutical intervention to treat asthma and other immune diseases. ..
  26. PKA in Reduction of Endothelial Permeability
    Hazel Lum; Fiscal Year: 2006
    ....
  27. Functional genomics of molluscan schistosome development
    TIMOTHY YOSHINO; Fiscal Year: 2009
    ..Results of this work may lead to novel strategies for controlling infections within the snail host by disrupting specific larval development-dependent genes or their products. ..
  28. IgE Regulation of Mast Cell Growth and Survival
    Toshiaki Kawakami; Fiscal Year: 2006
    ..abstract_text> ..
  29. Egr-1, PKC Beta, Signalling and Atherosclerosis
    Shi Fang Yan; Fiscal Year: 2009
    ....
  30. Molecular Mechanism of Troponin Function in Health and Disease
    Tomoyoshi Kobayashi; Fiscal Year: 2009
    ....
  31. Microvascular Regulation During Intestinal Absorption
    HAROLD G BOHLEN; Fiscal Year: 2010
    ..A substantial fraction of the NO in blood may be from NO loading in the small arteries based on their very high wall NO concentration and represents a new form of vascular regulation. ..
  32. PKC Signaling in cAMP-Induced Pulmonary Vasodilation
    SCOTT BARMAN; Fiscal Year: 2010
    ..Progress of these studies will provide important knowledge towards the development of novel therapeutic agents that will help reduce the morbidity and mortality associated with pulmonary hypertension. ..
  33. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..The greatest potential for arresting this epidemic is likely to come through a clearer understanding of its molecular pathogenesis to develop rational and mechanism based therapy. ..
  34. MOLECULAR NEUROBIOLOGY OF DEPRESSION
    Richard Shelton; Fiscal Year: 2003
    ..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..
  35. ENDOTHELIN EFFECTS ON RETINAL CELLS AND BLOOD FLOW
    George King; Fiscal Year: 2001
    ....
  36. MULTIPLE FORMS OF HEME OXYGENASE--REGULATION BY TOXINS
    MAHIN MAINES; Fiscal Year: 2001
    ..The nature of the second HO-2 immunoreactive protein in GC-treated rat testis also will be investigated. ..
  37. CELL BIOLOGY APPROACH TO DIABETIC RETINOPATHY
    George King; Fiscal Year: 2001
    ..effects through the activation of diacylglycerol-protein kinase C (DAG-PKC) pathway involving predominately PKC beta isoform which has been reported to increase extracellular matrix production, growth factor expression, and enzyme ..
  38. NEUTROPHIL TRANSENDOTHELIAL MIGRATION--OXIDATIVE STRESS
    Hazel Lum; Fiscal Year: 2001
    ....
  39. PROTEIN TYROSINE KINASES AND MAST CELL ACTIVATION
    Toshiaki Kawakami; Fiscal Year: 2001
    ..Particularly, interactions of Btk with Src PTKs and ERK might suggest positive and negative, respectively, feedback mechanisms for FceRI induced mast cell activation. ..
  40. PROTEIN KINASE C IN ISCHEMIC RENAL INJURY AND REPAIR
    Babu Padanilam; Fiscal Year: 2002
    ..These observations will be extended to test the effects of various PKC activators and inhibitors on renal function, morphology, cell proliferation, apoptosis and differentiation post- ischemia. ..
  41. IMMUNE PEPTIDES IN AEDES AEGYPTI
    TIMOTHY YOSHINO; Fiscal Year: 2002
    ....
  42. MICROVASCULAR CHARACTERISTICS OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 2002
    ..Positive results will confirm that chronic insulin resistance predisposes the microvasculature to abnormalities of endothelial function. However, antioxidants and inhibition of beta II isoenzymes of PKC may protect endothelial function. ..
  43. Heme Oxygenase-Regulation, Function&Clinical Application
    MAHIN MAINES; Fiscal Year: 2003
    ....
  44. Enhanced Program for Human Subject Protection
    George King; Fiscal Year: 2002
    ..III. To provide secure record storage facilities within existing research space by renovating currently unusable space. ..
  45. RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEM
    NEAL BARMACK; Fiscal Year: 2003
    ..abstract_text> ..
  46. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2005
    ..Genes will be delivered by CSF or by intracarotid route and the same indeces will be evaluated. ..
  47. Retinal imaging tests for microvascular functions
    George King; Fiscal Year: 2003
    ..These studies should provide us with information on whether retinal neural and vascular imaging function tests can be related to peripheral neural and microvascular dysfunctions and pathologies in diabetic patients. ..
  48. Monocyte VEGF & PKC, Markers for Diabetic Complications
    George King; Fiscal Year: 2003
    ..These data can provide definitive evidence to determine whether further studies are needed to establish these two parameters in the circulating monocyte as surrogate markers of diabetic microvascular diseases. ..
  49. Point-of-Care Measurement of Glycated Hemoglobin
    MARGO COHEN; Fiscal Year: 2004
    ....
  50. Mechanisms of Myocardial Radiofrequency Scar Expansion
    Rupak Mukherjee; Fiscal Year: 2004
    ..abstract_text> ..
  51. ANIMAL RESOURCES FACILITY EQUIPMENT IMPROVED PROJECT
    George King; Fiscal Year: 2004
    ..Not only will the requested improvements impact animal welfare, but they will also benefit the efficiency of the research animal program. ..
  52. Mechanisms of p42/44MAPK-induced LDL receptor expression
    KAMAL MEHTA; Fiscal Year: 2004
    ..This knowledge could be exploited to develop improved hypercholesterolemia therapies and to reduce foam cell formation. ..
  53. HYPERGLYCEMIA INHIBITION OF GLOMERULAR eNOS
    Shaoyou Chu; Fiscal Year: 2004
    ....
  54. PROTEIN KINASE C ACTIVATION AND DIABETIC CARDIOMYOPATHY
    George King; Fiscal Year: 2004
    ..Isolated cardiornyocytes from PKCB transgenic mice contracted poorly which was corrected by specific inhibitor (LY333531) to PKCB isoforms...
  55. Diabetic Retinopathy Clinical Research Network
    Lloyd Aiello; Fiscal Year: 2005
    ..This proposal details the manner in which the specific goals of the network will be fostered under the guidance of the Study Chair. ..
  56. Proteomic Biomarkers of Health Behaviors
    Paul Lampe; Fiscal Year: 2005
    ..abstract_text> ..
  57. Mast cell regulation by PKC and Akt
    Toshiaki Kawakami; Fiscal Year: 2005
    ..Given the critical importance of PKC in degranulation and other activation events, these studies are also likely to provide an opportunity for novel therapeutic modalities aimed at allergic diseases. ..