PKC alpha

Summary

Gene Symbol: PKC alpha
Description: protein kinase C alpha
Alias: AAG6, PKC-alpha, PKCA, PRKACA, protein kinase C alpha type, PKC-A, aging-associated gene 6
Species: human
Products:     PKC alpha

Top Publications

  1. Tam W, Lu H, Buikhuisen J, Soh B, Lim E, Reinhardt F, et al. Protein kinase C ? is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell. 2013;24:347-64 pubmed publisher
    ..Hence, identifying molecular features that shift between cell states can be exploited to target signaling components critical to CSCs. ..
  2. Abdala Valencia H, Berdnikovs S, Cook Mills J. Mechanisms for vascular cell adhesion molecule-1 activation of ERK1/2 during leukocyte transendothelial migration. PLoS ONE. 2011;6:e26706 pubmed publisher
    ..VCAM-1 activation of endothelial cell NADPH oxidase/PKC?/PTP1B induces transient ERK1/2 activation that is necessary for VCAM-1-dependent leukocyte TEM. ..
  3. Haughian J, Reno E, Thorne A, Bradford A. Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis. Int J Cancer. 2009;125:2556-64 pubmed publisher
    ..Thus, targeting PKCalpha may provide novel therapeutic options in endometrial tumors. ..
  4. Cheng C, Hsieh H, Sun C, Lin C, Luo S, Yang C. IL-1 beta induces urokinase-plasminogen activator expression and cell migration through PKC alpha, JNK1/2, and NF-kappaB in A549 cells. J Cell Physiol. 2009;219:183-93 pubmed publisher
    ..In this study, IL-1 beta significantly induced uPA expression and activity via PKC alpha-dependent JNK1/2 and NIK cascades, linking to IKK alpha/beta activation, p65 translocation and transcription ..
  5. Lee S, Shehzad A, Jung J, Sonn J, Lee J, Park J, et al. Protein kinase C? protects against multidrug resistance in human colon cancer cells. Mol Cells. 2012;34:61-9 pubmed publisher
  6. Ranganathan S, Liu C, Migliorini M, von Arnim C, Peltan I, Mikhailenko I, et al. Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules. J Biol Chem. 2004;279:40536-44 pubmed
    ..These results indicate that phosphorylation of LRP by PKCalpha modulates the endocytic and signaling function of LRP by modifying its association with adaptor proteins. ..
  7. Lønne G, Cornmark L, Zahirovic I, Landberg G, Jirstrom K, Larsson C. PKCalpha expression is a marker for breast cancer aggressiveness. Mol Cancer. 2010;9:76 pubmed publisher
    ..PKCalpha inhibition or downregulation also reduced cell migration in vitro. PKCalpha is a marker for poor prognosis of breast cancer and correlates to and is important for cell functions associated with breast cancer progression. ..
  8. Lin K, Fang C, Uen Y, Chang C, Lou H, Hsieh C, et al. Overexpression of protein kinase Calpha mRNA may be an independent prognostic marker for gastric carcinoma. J Surg Oncol. 2008;97:538-43 pubmed publisher
    ..0275). Our results suggest that overexpression of PKCalpha mRNA has correlation with distant metastasis and may be an independent prognostic marker for gastric carcinoma. ..
  9. de Quervain D, Kolassa I, Ackermann S, Aerni A, Boesiger P, Demougin P, et al. PKC? is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors. Proc Natl Acad Sci U S A. 2012;109:8746-51 pubmed publisher
    ..Our results indicate a role for PKC? in memory and suggest a genetic link between memory and the risk for PTSD. ..

More Information

Publications77

  1. Pascale A, Amadio M, Scapagnini G, Lanni C, Racchi M, Provenzani A, et al. Neuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway. Proc Natl Acad Sci U S A. 2005;102:12065-70 pubmed
    ..These findings suggest a model for gene expression regulation by nELAV proteins through a PKCalpha-dependent pathway that is relevant for the cellular programs in which ARE-mediated control plays a pivotal role. ..
  2. Du H, Ou L, Yang X, Song X, Fan Y, Tan B, et al. A new PKC?/?/TBX3/E-cadherin pathway is involved in PLC?-regulated invasion and migration in human bladder cancer cells. Cell Signal. 2014;26:580-93 pubmed publisher
    ..In summary, our findings uncover that PKC?/? is critical for PLC?-mediated cancer cell invasion and migration and provide valuable insights for current and future Ad-shPLC? and PKC?/? clinical trials. ..
  3. Zhang B, Wu Q, Ye X, Liu S, Lin X, Chen M. Roles of PLC-gamma2 and PKCalpha in TPA-induced apoptosis of gastric cancer cells. World J Gastroenterol. 2003;9:2413-8 pubmed
    ..As an effector, PKCalpha directly promotes apoptosis of MGC80-3 cells. Therefore, protein translocation of PLCgamma2 and PKCalpha is critical event in the process of apoptosis induction. ..
  4. Yang L, Ng D, Bikle D. Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma. J Cell Physiol. 2003;195:249-59 pubmed
    ..Failure to regulate PKC [alpha] in SCC4 may underlie at least part of the failure of calcium to promote differentiation in these cells. ..
  5. Kohutek Z, diPierro C, Redpath G, Hussaini I. ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration. J Neurosci. 2009;29:4605-15 pubmed publisher
    ..Together, these results suggest that N-cadherin cleavage is regulated by a PKC-alpha-ADAM-10 cascade in GBM cells and may be involved in mediating GBM cell migration. ..
  6. Lang W, Wang H, Ding L, Xiao L. Cooperation between PKC-alpha and PKC-epsilon in the regulation of JNK activation in human lung cancer cells. Cell Signal. 2004;16:457-67 pubmed
    ..Furthermore, using dominant negative mutants and pharmacological inhibitors, we define that a putative Rac1/Cdc42/PKC-alpha pathway is convergent with the PKC-epsilon/MEK1/2 pathway in terms of the activation of JNK by PMA. ..
  7. Lee Kwon W, Kim J, Choi J, Kawano K, Cha B, Dartt D, et al. Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes. Am J Physiol Cell Physiol. 2003;285:C1527-36 pubmed
    ..These results suggest that PKCalpha is not necessary for the Ca2+-dependent formation of the NHE3 plasma membrane complex, although it is necessary for decreasing the membrane amounts of NHE3, probably by stimulating NHE3 endocytosis. ..
  8. Doller A, Huwiler A, Müller R, Radeke H, Pfeilschifter J, Eberhardt W. Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2. Mol Biol Cell. 2007;18:2137-48 pubmed
    ..protein kinase C (PKC) inhibitors and small interfering RNA approaches, we demonstrated that knockdown of PKC alpha efficiently blocked the ATP-dependent nuclear HuR export to the cytoplasm...
  9. Haughian J, Bradford A. Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells. J Cell Physiol. 2009;220:112-8 pubmed publisher
  10. Zhan B, Kong C, Guo K, Zhang Z. PKC? is involved in the progression of kidney carcinoma through regulating netrin-1/UNC5B signaling pathway. Tumour Biol. 2013;34:1759-66 pubmed publisher
    ..Our data highly suggested that PMA-induced upregulation and calphostin C-induced reversion of netrin-1 and UNC5B in kidney carcinoma were accompanied by the activation of the netrin-1/UNC5B pathways. ..
  11. Evans J, Murray D, Leslie C, Falke J. Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain. Mol Biol Cell. 2006;17:56-66 pubmed
    ..Instead, targeting specificity is provided by basic residues on beta-strands 3-4, which bind to plasma membrane PIP2. ..
  12. Aaltonen V, Koivunen J, Laato M, Peltonen J. Heterogeneity of cellular proliferation within transitional cell carcinoma: correlation of protein kinase C alpha/betaI expression and activity. J Histochem Cytochem. 2006;54:795-806 pubmed
    ..Furthermore, these results suggest that even in carcinoma tissue, PKC expression and activity are under strict control. ..
  13. Stahelin R, Wang J, Blatner N, Rafter J, Murray D, Cho W. The origin of C1A-C2 interdomain interactions in protein kinase Calpha. J Biol Chem. 2005;280:36452-63 pubmed
    ..Collectively, these studies provide new structural insight into PKCalpha C1A-C2 interdomain interactions and the mechanism of lipid-mediated PKCalpha activation. ..
  14. Kyuno D, Kojima T, Yamaguchi H, Ito T, Kimura Y, Imamura M, et al. Protein kinase C? inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer. Carcinogenesis. 2013;34:1232-43 pubmed publisher
    ..Thus, PKC? inhibitors may be potential therapeutic agents against the malignancy of human pancreatic cancer cells. ..
  15. Kroviarski Y, Debbabi M, Bachoual R, Perianin A, Gougerot Pocidalo M, El Benna J, et al. Phosphorylation of NADPH oxidase activator 1 (NOXA1) on serine 282 by MAP kinases and on serine 172 by protein kinase C and protein kinase A prevents NOX1 hyperactivation. FASEB J. 2010;24:2077-92 pubmed publisher
    ..These results demonstrated a critical role of NOXA1 phosphorylation on Ser-282 and Ser-172 in preventing NOX1 hyperactivation through the decrease of NOXA1 interaction to NOX1 and Rac1. ..
  16. Frankel L, Lykkesfeldt A, Hansen J, Stenvang J. Protein Kinase C alpha is a marker for antiestrogen resistance and is involved in the growth of tamoxifen resistant human breast cancer cells. Breast Cancer Res Treat. 2007;104:165-79 pubmed
    ..Furthermore, our data suggest the potential for PKCalpha as a marker for antiestrogen resistance and as a promising therapeutic target in the treatment of tamoxifen resistant breast cancer. ..
  17. Rastaldi M, Candiano G, Musante L, Bruschi M, Armelloni S, Rimoldi L, et al. Glomerular clusterin is associated with PKC-alpha/beta regulation and good outcome of membranous glomerulonephritis in humans. Kidney Int. 2006;70:477-85 pubmed
    ..Binding of clusterin to the LDL-R might offer an interpretative key for the pathogenesis of MGN in humans...
  18. Du C, Xu Y, Liu X, Xie J, Xie M, Zhang Z, et al. Up-regulation of cyclin D1 expression in asthma serum-sensitized human airway smooth muscle promotes proliferation via protein kinase C alpha. Exp Lung Res. 2010;36:201-10 pubmed publisher
    ..The authors' previous studies have indicated that protein kinase C alpha (PKC alpha) is involved in the proliferation of passively sensitized human airway smooth muscle cells (HASMCs)...
  19. Makagiansar I, Williams S, Dahlin Huppe K, Fukushi J, Mustelin T, Stallcup W. Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility. J Biol Chem. 2004;279:55262-70 pubmed
    ..PKC-alpha-mediated NG2 phosphorylation at Thr(2256) is therefore a key step for initiating cell polarization and motility. ..
  20. von Knethen A, Tautenhahn A, Link H, Lindemann D, Brüne B. Activation-induced depletion of protein kinase C alpha provokes desensitization of monocytes/macrophages in sepsis. J Immunol. 2005;174:4960-5 pubmed
    ..Inhibition of the oxidative burst and depletion of protein kinase C alpha (PKC alpha) were correlated in septic patients...
  21. Wen Sheng W, Jun Ming H. Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2. J Biomed Sci. 2005;12:289-96 pubmed
    ..Taken together, we concluded that PKCalpha is specifically required for TPA-induced ERK(MAPK) signaling to trigger gene expressions of p15(INK4b) and p16(INK4a) leading to HepG2 growth inhibition. ..
  22. Ananthanarayanan B, Stahelin R, Digman M, Cho W. Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains. J Biol Chem. 2003;278:46886-94 pubmed
    ..These data suggest that differential activation mechanisms of PKC isoforms are determined by the DAG affinity and conformational flexibility of their C1 domains. ..
  23. Wu T, Hsieh Y, Wu C, Hsieh Y, Huang C, Liu J. Overexpression of protein kinase C alpha mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis. Clin Chim Acta. 2007;382:54-8 pubmed
    ..01). Our results suggested that the PKCalpha may be a prognostic factor for the survival of patients with HCC. ..
  24. O Neill A, Gallegos L, Justilien V, Garcia E, Leitges M, Fields A, et al. Protein kinase C? promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). J Biol Chem. 2011;286:43559-68 pubmed publisher
    ..Taken together, these data establish the requirement of scaffolding to DLG1 for PKC? to promote cellular migration. ..
  25. Lucas R, Yang G, Gorshkov B, Zemskov E, Sridhar S, Umapathy N, et al. Protein kinase C-? and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. Am J Respir Cell Mol Biol. 2012;47:445-53 pubmed publisher
    ..These results identify PKC-? and arginase I as potential upstream and downstream therapeutic targets in PLY-induced pulmonary endothelial dysfunction. ..
  26. Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, et al. Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature. 1993;364:249-52 pubmed
    ..Here we investigate the molecular mechanism and biological consequences of PKC alpha-mediated Raf-1 activation in NIH3T3 fibroblasts...
  27. Cheng J, Wung B, Chao Y, Wang D. Sequential activation of protein kinase C (PKC)-alpha and PKC-epsilon contributes to sustained Raf/ERK1/2 activation in endothelial cells under mechanical strain. J Biol Chem. 2001;276:31368-75 pubmed
    ..Our findings conclude that a sequential activation of PKC isoform (alpha and epsilon) contribute to Raf/ERK1/2 activation, and PKC-epsilon appears to play a key role in endothelial adaptation to hemodynamic environment. ..
  28. Fontayne A, Dang P, Gougerot Pocidalo M, El Benna J. Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation. Biochemistry. 2002;41:7743-50 pubmed
    ..In this study, we found that PKC isoforms known to be present in human neutrophils (PKC alpha, beta, delta, and zeta) phosphorylate p47(phox) in a time- and concentration-dependent manner, with apparent K(m)..
  29. Rabinovitz I, Toker A, Mercurio A. Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells. J Cell Biol. 1999;146:1147-60 pubmed
  30. Besson A, Yong V. Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression. Mol Cell Biol. 2000;20:4580-90 pubmed
    ..Of the six PKC isoforms that were present in glioma cells, PKC alpha was both necessary and sufficient to promote cell cycle progression when stimulated with phorbol 12-myristate 13-..
  31. Noland T, Raynor R, Kuo J. Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites. J Biol Chem. 1989;264:20778-85 pubmed
  32. Jideama N, Noland T, Raynor R, Blobe G, Fabbro D, Kazanietz M, et al. Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem. 1996;271:23277-83 pubmed
    ..The present study has demonstrated for the first time distinct specificities of PKC isozymes for phosphorylation of two physiological substrates in the myocardium, with functional consequences. ..
  33. Parsons M, Keppler M, Kline A, Messent A, Humphries M, Gilchrist R, et al. Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Mol Cell Biol. 2002;22:5897-911 pubmed
    ..Protein kinase C alpha (PKC alpha) has been implicated in the promotion of a migratory cell phenotype...
  34. Diaz Rodriguez E, Montero J, Esparís Ogando A, Yuste L, Pandiella A. Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. Mol Biol Cell. 2002;13:2031-44 pubmed
  35. Sukumaran S, Prasadarao N. Regulation of protein kinase C in Escherichia coli K1 invasion of human brain microvascular endothelial cells. J Biol Chem. 2002;277:12253-62 pubmed
    ..This is the first report of FAK- and PI3K-dependent PKC-alpha activation in bacterial invasion related to cytoskeletal reorganization. ..
  36. Gardoni F, Bellone C, Cattabeni F, Di Luca M. Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex. J Biol Chem. 2001;276:7609-13 pubmed
    ..Thus, our data provide clues on understanding the molecular basis of a direct cross-talk between alphaCaMKII and PKC pathways in the postsynaptic compartment. ..
  37. Oancea E, Meyer T. Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell. 1998;95:307-18 pubmed
    ..The properties of this molecular decoding machine make PKCgamma responsive to persistent diacylglycerol increases combined with high- but not low-frequency calcium spikes. ..
  38. Ruvolo P, Deng X, Carr B, May W. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. J Biol Chem. 1998;273:25436-42 pubmed
    ..Collectively, these findings identify a functional role for PKCalpha in Bcl2 phosphorylation and in resistance to chemotherapy and suggest a novel target for antileukemic strategies. ..
  39. Venugopal S, Devaraj S, Yang T, Jialal I. Alpha-tocopherol decreases superoxide anion release in human monocytes under hyperglycemic conditions via inhibition of protein kinase C-alpha. Diabetes. 2002;51:3049-54 pubmed
  40. Detjen K, Brembeck F, Welzel M, Kaiser A, Haller H, Wiedenmann B, et al. Activation of protein kinase Calpha inhibits growth of pancreatic cancer cells via p21(cip)-mediated G(1) arrest. J Cell Sci. 2000;113 ( Pt 17):3025-35 pubmed
  41. Stoney P, Rodrigues D, Helfer G, Khatib T, Ashton A, Hay E, et al. A seasonal switch in histone deacetylase gene expression in the hypothalamus and their capacity to modulate nuclear signaling pathways. Brain Behav Immun. 2017;61:340-352 pubmed publisher
  42. Thomason H, Cooper N, Ansell D, Chiu M, Merrit A, Hardman M, et al. Direct evidence that PKC? positively regulates wound re-epithelialization: correlation with changes in desmosomal adhesiveness. J Pathol. 2012;227:346-56 pubmed publisher
    ..These results throw new mechanistic light on the earliest stages of wound re-epithelialization and suggest activation of PKC? as a new therapeutic strategy for non-healing wounds. ..
  43. Nicod J, Davies R, Cai N, Hassett C, Goodstadt L, Cosgrove C, et al. Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing. Nat Genet. 2016;48:912-8 pubmed publisher
    ..These findings have implications for diverse areas of mammalian biology and demonstrate how genome-wide association studies can be extended via low-coverage sequencing to species with highly recombinant outbred populations. ..
  44. Juno J, Fowke K. Clarifying the role of G protein signaling in HIV infection: new approaches to an old question. AIDS Rev. 2010;12:164-76 pubmed
  45. Redden J, Le A, Singh A, Federkiewicz K, Smith S, Dodge Kafka K. Spatiotemporal regulation of PKC via interactions with AKAP7 isoforms. Biochem J. 2012;446:301-9 pubmed publisher
    ..Collectively, the results of the present study suggests that AKAP7 could play an integral role in dictating PKC localization and function in tissues where the two proteins are co-expressed. ..
  46. Gu J, Lu W, Xia C, Wu X, Liu M. Regulation of hematopoietic-specific G-protein Galpha15 and Galpha16 by protein kinase C. J Cell Biochem. 2003;88:1101-11 pubmed
  47. Baio J, Martinez A, Bailey L, Hasaniya N, Pecaut M, Kearns Jonker M. Spaceflight Activates Protein Kinase C Alpha Signaling and Modifies the Developmental Stage of Human Neonatal Cardiovascular Progenitor Cells. Stem Cells Dev. 2018;: pubmed publisher
    ..Further research both in space and on Earth may help refine the use of CPCs in stem cell-based therapies and highlight the molecular events of development. ..
  48. Zemskov E, Nukina N. Impaired degradation of PKCalpha by proteasome in a cellular model of Huntington's disease. Neuroreport. 2003;14:1435-8 pubmed
    ..Our data suggest an impairment of the degradation of PKCalpha in HD 150Q cells. This impairment is likely to be connected with the sequestration of proteasome on mutant huntingtin aggregates. ..
  49. Das J, Ramani R, Suraju M. Polyphenol compounds and PKC signaling. Biochim Biophys Acta. 2016;1860:2107-21 pubmed publisher
    ..The fact that 74% of the cancer drugs are derived from natural sources, naturally occurring polyphenols or its simple analogs with improved bioavailability may have the potential to be cancer drugs in the future. ..
  50. Farber B, Lalazar G, Simon E, Hammond W, Requena D, Bhanot U, et al. Non coding RNA analysis in fibrolamellar hepatocellular carcinoma. Oncotarget. 2018;9:10211-10227 pubmed publisher
    ..This produces a fusion of the genes DNAJB1 and PRKACA which, in turn, produces a chimeric transcript and protein...
  51. Imai S, Kai M, Yamada K, Kanoh H, Sakane F. The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain. Biochem J. 2004;382:957-66 pubmed
    ..Our results provide evidence of the phosphorylation of the DGKdelta1 PH domain by cPKC, and suggest that the phosphorylation is involved in the control of subcellular localization of DGKdelta1. ..
  52. Huwiler A, Döll F, Ren S, Klawitter S, Greening A, Römer I, et al. Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism. Biochim Biophys Acta. 2006;1761:367-76 pubmed
  53. Singhal S, Yadav S, Singhal J, Drake K, Awasthi Y, Awasthi S. The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer. FEBS Lett. 2005;579:4635-41 pubmed
    ..These finding offer a novel explanation for the observed intrinsic differences in sensitivity to DOX between non-small cell and small cell lung cancer cell lines...
  54. Hackler L, Ózsvári B, Gyuris M, Sipos P, Fábián G, Molnár E, et al. The Curcumin Analog C-150, Influencing NF-κB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo. PLoS ONE. 2016;11:e0149832 pubmed publisher
    ..The multi-target action of C-150, and its preliminary in vivo efficacy would render this curcumin analogue as a potent clinical candidate against glioblastoma. ..
  55. Chen W, ten Berge D, Brown J, Ahn S, Hu L, Miller W, et al. Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science. 2003;301:1391-4 pubmed
    ..These findings provide a previously unrecognized mechanism for receptor recruitment of beta-arrestin and demonstrate that Dvl plays an important role in the endocytosis of frizzled, as well as in promoting signaling. ..
  56. Fu Q, Song X, Liu Z, Deng X, Luo R, Ge C, et al. miRomics and Proteomics Reveal a miR-296-3p/PRKCA/FAK/Ras/c-Myc Feedback Loop Modulated by HDGF/DDX5/?-catenin Complex in Lung Adenocarcinoma. Clin Cancer Res. 2017;23:6336-6350 pubmed publisher
    ..i>Clin Cancer Res; 23(20); 6336-50. ©2017 AACR. ..
  57. Spinelli C, Carrizzo A, Ferrario A, Villa F, Damato A, Ambrosio M, et al. LAV-BPIFB4 isoform modulates eNOS signalling through Ca2+/PKC-alpha-dependent mechanism. Cardiovasc Res. 2017;113:795-804 pubmed publisher
    ..These results highlight the role LAV-BPIFB4 can have in restoring signals that are lost during ageing. ..
  58. Kinehara M, Kawamura S, Mimura S, Suga M, Hamada A, Wakabayashi M, et al. Protein kinase C-induced early growth response protein-1 binding to SNAIL promoter in epithelial-mesenchymal transition of human embryonic stem cells. Stem Cells Dev. 2014;23:2180-9 pubmed publisher
    ..This study would lead to a more robust understanding of the mechanisms underlying the balance between self-renewal and initiation of differentiation in hPS cells. ..
  59. Andrikopoulos P, Baba A, Matsuda T, Djamgoz M, Yaqoob M, Eccles S. Ca2+ influx through reverse mode Na+/Ca2+ exchange is critical for vascular endothelial growth factor-mediated extracellular signal-regulated kinase (ERK) 1/2 activation and angiogenic functions of human endothelial cells. J Biol Chem. 2011;286:37919-31 pubmed publisher
  60. Moen L, Şener Z, Volchenkov R, Svarstad A, Eriksen A, Holen H, et al. Ablation of the C?2 subunit of PKA in immune cells leads to increased susceptibility to systemic inflammation in mice. Eur J Immunol. 2017;47:1880-1889 pubmed publisher
    ..There are two major catalytic subunit genes, PRKACA and PRKACB encoding the catalytic subunits C? and C?...
  61. Averna M, Bavestrello M, Cresta F, Pedrazzi M, De Tullio R, Minicucci L, et al. Abnormal activation of calpain and protein kinase Cα promotes a constitutive release of matrix metalloproteinase 9 in peripheral blood mononuclear cells from cystic fibrosis patients. Arch Biochem Biophys. 2016;604:103-12 pubmed publisher
  62. Blaheta R, Powerski M, Hudak L, Juengel E, Jonas D, von Knethen A, et al. Tumor-endothelium cross talk blocks recruitment of neutrophils to endothelial cells: a novel mechanism of endothelial cell anergy. Neoplasia. 2009;11:1054-63 pubmed
    ..A novel tumor escape strategy is presented here. Cell contact-dependent adhesion of tumor cells to the vascular wall promotes down-regulation of endothelial CD44 receptor expression, impairing an effective neutrophil attack. ..
  63. Xaing M, Liu X, Zeng D, Wang R, Xu Y. Changes of protein kinase Calpha and cyclin D1 expressions in pulmonary arteries from smokers with and without chronic obstructive pulmonary disease. J Huazhong Univ Sci Technolog Med Sci. 2010;30:159-64 pubmed publisher
    ..01). In conclusion, increased expressions of PKCalpha and cyclin D1 might be involved in the pathogenesis of abnormal proliferation of PASMCs in smokers with normal lung function and smokers with mild to moderate COPD. ..
  64. Pula G, Crosby D, Baker J, Poole A. Functional interaction of protein kinase Calpha with the tyrosine kinases Syk and Src in human platelets. J Biol Chem. 2005;280:7194-205 pubmed
    ..Therefore, there is a complex interplay between PKCalpha, Syk, and Src involving physical interaction, phosphorylation, translocation within the cell, and functional activity regulation. ..
  65. von Knethen A, Soller M, Tzieply N, Weigert A, Johann A, Jennewein C, et al. PPARgamma1 attenuates cytosol to membrane translocation of PKCalpha to desensitize monocytes/macrophages. J Cell Biol. 2007;176:681-94 pubmed
    ..Therefore, we conclude that PPARgamma1-dependent inhibition of PKCalpha translocation implies a new model of macrophage desensitization. ..
  66. Francis H, Onori P, Gaudio E, Franchitto A, Demorrow S, Venter J, et al. H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo. Mol Cancer Res. 2009;7:1704-13 pubmed publisher
    ..RAMH inhibits cholangiocarcinoma growth by PKCalpha-dependent ERK1/2 dephosphorylation. Modulation of PKCalpha by histamine receptors may be important in regulating cholangiocarcinoma growth. ..
  67. Brandon N, Jovanovic J, Colledge M, Kittler J, Brandon J, Scott J, et al. A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits. Mol Cell Neurosci. 2003;22:87-97 pubmed
    ..Therefore, the selective interaction of beta subunits with AKAP150 may facilitate GABA(A) receptor subtype-specific functional modulation by PKA activity which may have profound local effects on neuronal excitation. ..
  68. Kobayashi T, Winslow S, Sunesson L, Hellman U, Larsson C. PKC? binds G3BP2 and regulates stress granule formation following cellular stress. PLoS ONE. 2012;7:e35820 pubmed publisher
    ..In conclusion this study identifies novel interaction partners of PKC? and a novel role for PKC? in regulation of stress granules...